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https://www.readbyqxmd.com/read/29783164/potential-risks-from-uv-h-2-o-2-oxidation-and-uv-photocatalysis-a-review-of-toxic-assimilable-and-sensory-unpleasant-transformation-products
#1
REVIEW
Wen-Long Wang, Qian-Yuan Wu, Nan Huang, Zi-Bin Xu, Min-Yong Lee, Hong-Ying Hu
UV based advanced oxidation processes (UV-AOPs) that efficiently eliminate organic pollutants during water treatment have been the subject of numerous investigations. Most organic pollutants are not completely mineralized during UV-AOPs but are partially oxidized into transformation products (TPs), thereby adding complexity to the treated water and posing risks to humans, ecological systems, and the environment. While the degradation kinetics and mechanisms of pollutants have been widely documented, there is little information about the risks associated with TPs...
May 15, 2018: Water Research
https://www.readbyqxmd.com/read/29779496/invited-review-improving-feed-efficiency-of-beef-cattle-the-current-state-of-the-art-and-future-challenges
#2
D A Kenny, C Fitzsimons, S M Waters, M McGee
Improvements in feed efficiency of beef cattle have the potential to increase producer profitability and simultaneously lower the environmental footprint of beef production. Although there are many different approaches to measuring feed efficiency, residual feed intake (RFI) has increasingly become the measure of choice. Defined as the difference between an animal's actual and predicted feed intake (based on weight and growth), RFI is conceptually independent of growth and body size. In addition, other measurable traits related to energy expenditure such as estimates of body composition can be included in the calculation of RFI to also force independence from these traits...
May 21, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29778909/n-acetylcysteine-protects-against-diabetic-nephropathy-through-control-of-oxidative-and-nitrosative-stress-by-recovery-of-nitric-oxide-in-rats
#3
Guilherme B Nogueira, Giovana R Punaro, Clemerson S Oliveira, Fabiane R Maciel, Thamires O Fernandes, Deyse Y Lima, Adelson M Rodrigues, Margaret G Mouro, Sergio R R Araujo, Elisa M S Higa
The diabetes mellitus (DM) induces several changes, with substantial increase of reactive oxygen species (ROS). The ROS cause damage to systemic and renal microvasculature, which could be one of the mechanisms involved in the development of diabetic nephropathy (DN). The ROS modulate other substances like the nitric oxide (NO), a vasodilator with important role in the renal function. N-acetylcysteine (NAC) is an antioxidant that acts replenishing intracellular cysteine levels, which is essential for glutathione formation...
May 17, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29778874/simultaneous-determination-of-dihydrotestosterone-and-its-metabolites-in-mouse-sera-by-lc-ms-ms-with-chemical-derivatization
#4
Shashank Gorityala, Shuming Yang, Monica M Montano, Yan Xu
Androgens play a vital role in prostate cancer development, and their elimination and blockade are essential in the disease management. DHT is the key ligand for androgen receptor (AR) in the prostate. It is locally synthesized from testosterone. In the prostate, DHT is predominantly metabolized to α-diol and β-diol. Recent studies indicate that impaired DHT catabolism is associated with prostate cancer, signifying the necessity of a sensitive quantitative method for the determination of DHT and its metabolites...
May 16, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29778594/differetial-toxin-profiles-of-ciguatoxins-in-marine-organisms-chemistry-fate-and-global-distribution
#5
REVIEW
Lucía Soliño, Pedro Reis Costa
Ciguatoxins (CTXs) are fish metabolism products and a result of biotransformation of precursor gambiertoxins produced, in the first instance, by benthic dinoflagellates Gambierdiscus and Fukuyoa. Ciguatoxins are potent neurotoxins that selectively open voltage gated sodium channels in excitable cells causing the human food poisoning known as Ciguatera (CFP). Endemic from tropical areas in central Pacific and West Indian Ocean, and the Caribbean Sea, CTX may affects up to 500,000 people annually due to fish consumption...
May 17, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29778080/atrazine-xenobiotic-nuclear-receptor-interactions-induce-cardiac-inflammation-and-endoplasmic-reticulum-stress-in-quail-coturnix-coturnix-coturnix
#6
Xue-Nan Li, Yu-Zhu Zuo, Lei Qin, Wei Liu, Yan-Hua Li, Jin-Long Li
Atrazine (ATR) is one of the most extensively used herbicide that eventually leaches into groundwater and surface water from agricultural areas. Exposure to ATR does harm to the health of human and animals, especially the heart. However, ATR exposure caused cardiotoxicity in bird remains unclear. To evaluate ATR-exerted potential cardiotoxicity in heart, quail were exposed with 0, 50, 250, and 500 mg/kg BW/day ATR by gavage treatment for 45 days. Cardiac histopathological alternation was observed in ATR-induced quail...
May 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29778055/new-insights-into-the-effects-of-support-matrix-on-the-removal-of-organic-micro-pollutants-and-the-microbial-community-in-constructed-wetlands
#7
Liang Zhang, Tao Lyu, Carlos Andrés Ramírez Vargas, Carlos A Arias, Pedro N Carvalho, Hans Brix
Constructed wetlands (CWs) are an eco-friendly and cost-effective technology to remove organic micro-pollutants (OMPs) from wastewater. The support matrix is an important component in CWs as it has a primary role in the growth and development of plants and microbes. However, the roles of the support matrix in CWs in removing OMPs have not been systematically studied. Therefore, in this study, six common materials (sand, zeolite, blast iron slag, petcoke, polonite and crushed autoclaved aerated concrete (CAAC)) as support matrixes were firstly investigated by batch tests to explore their adsorption capacities to selected OMPs (ibuprofen, iohexol, tebuconazole and imazalil)...
May 16, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29776593/heat-shock-influences-the-fatty-acid-composition-of-the-muscle-of-the-antarctic-fish-trematomus-bernacchii
#8
C Truzzi, S Illuminati, M Antonucci, G Scarponi, A Annibaldi
In the Ross Sea region (average temperature of -1.87 °C), shelf water warming up to +0.8-+1.4 °C is predicted by 2200, so there is an urgent need to understand how organisms can respond to rising temperatures. In this study, we analyzed the effect of a heat shock on the fatty acid (FAs) composition of muscle of the Antarctic teleost Trematomus bernacchii, caught in Terra Nova Bay (Ross Sea), and held in fish tanks at 0, +1 or +2 °C, for 1, 5 and 10 days. In general, heat shock produced, beyond a reduction in total lipid content correlated to the temperature, an increase in the percentage of saturated FAs, and a decrease in mono-unsaturated FAs; however, the level of poly-unsaturated FAs did not seem to directly correlate with temperature...
April 3, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29775936/from-hit-to-lead-structure-based-discovery-of-naphthalene-1-sulfonamide-derivatives-as-potent-and-selective-inhibitors-of-fatty-acid-binding-protein-4
#9
Ding-Ding Gao, Hui-Xia Dou, Hai-Xia Su, Ming-Ming Zhang, Ting Wang, Qiu-Feng Liu, Hai-Yan Cai, Hai-Peng Ding, Zhuo Yang, Wei-Liang Zhu, Ye-Chun Xu, He-Yao Wang, Ying-Xia Li
Fatty acid binding protein 4 (FABP4) plays a critical role in metabolism and inflammatory processes and therefore is a potential therapeutic target for immunometabolic diseases such as diabetes and atherosclerosis. Herein, we reported the identification of naphthalene-1-sulfonamide derivatives as novel, potent and selective FABP4 inhibitors by applying a structure-based design strategy. The binding affinities of compounds 16dk, 16do and 16du to FABP4, at the molecular level, are equivalent to or even better than that of BMS309403...
May 9, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29773193/boron-intake-osteocalcin-polymorphism-and-serum-level-in-postmenopausal-osteoporosis
#10
Olcay Boyacioglu, Seda Orenay-Boyacioglu, Hatice Yildirim, Mehmet Korkmaz
The relationship between daily boron intake and osteocalcin-mediated osteoporosis was studied in boron-exposed postmenopausal women. It is known that boron and osteocalcin are important in bone metabolism, however the effect of boron in bone metabolism has not been fully discovered. The study was performed on 53 postmenopausal women aged 55-60 living in parts of Balikesir, Turkey, where the subjects are naturally exposed to high (≥1 mg/L) or low (<1 mg/L) boron concentration in drinking water. 24-h urine samples were collected from all participants and creatinine clearance was detected...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29770190/effects-of-molecular-hydrogen-dissolved-alkaline-electrolyzed-water-on-intestinal-environment-in-mice
#11
Yasuki Higashimura, Yasunori Baba, Ryo Inoue, Tomohisa Takagi, Kazuhiko Uchiyama, Katsura Mizushima, Yasuko Hirai, Chihiro Ushiroda, Yoshinori Tanaka, Yuji Naito
Increasing evidence indicates that molecular hydrogen-dissolved alkaline electrolyzed water (AEW) has various physiological activities such as antioxidative activity. Gut microbiota are deeply associated with our health through a symbiotic relationship. Recent reports have described that most gastrointestinal microbial species encode the genetic capacity to metabolize molecular hydrogen, meaning that molecular hydrogen might affect the gut microbial composition. Nevertheless, AEW effects on gut microbiota remain unknown...
January 2018: Medical Gas Research
https://www.readbyqxmd.com/read/29768919/molecular-mechanism-of-modified-clay-controlling-the-brown-tide-organism-aureococcus-anophagefferens-revealed-by-transcriptome-analysis
#12
Jianan Zhu, Zhiming Yu, Liyan He, Xihua Cao, Shuya Liu, Xiuxian Song
The data and experiences in mitigating harmful algal blooms (HABs) by modified clay (MC) show that a bloom does not continue after the dispersal of the MC, even though the density of the residual cells in the water is still high, at 20-30% of the initial cell density. This interesting phenomenon indicates that in addition to flocculation, MC has an additional control mechanism. Here, transcriptome sequencing technology was used to study the molecular mechanism of MC in controlling HABs. In residual cells treated with MC, the photosynthetic light reaction was the most affected physiological process...
May 16, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29768636/water-related-mechanisms-proposed-for-storing-and-transmitting-homeopathic-information-putative-links-with-biological-responses
#13
José Roberto Pereira Guedes, Leoni Villano Bonamin, Vera Luiza Capelozzi
INTRODUCTION:  There are two critical pillars of homeopathy that contrast with the dominant scientific approach: the similitude principle and the potentization of serial dilutions. Three main hypotheses about the mechanisms of action are in discussion: nanobubbles-related hormesis; vehicle-related electric resonance; and quantum non-locality. OBJECTIVES:  The aim of this paper is to review and discuss some key points of such properties: the imprint of supramolecular structures based on the nanoparticle-allostatic, cross-adaptation-sensitization (NPCAS) model; the theory of non-molecular electromagnetic transfer of information, based on the coherent water domains model, and relying (like the NPCAS model) on the idea of local interactions; and the hypothesis of quantum entanglement, based on the concept of non-locality...
May 16, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29768122/long-term-trait-consistency-in-mice-selected-for-swim-induced-high-aerobic-capacity
#14
Julita Sadowska, Andrzej K Gębczyński, Marek Konarzewski
The majority of studies show that metabolic rates are usually repeatable at the individual level, although their repeatabilities tend to decline with time and to be strongly affected by physiological changes. Changes in individual repeatabilities may therefore affect putative differences between experimental groups or populations. This problem is particularly relevant to artificial selection experiments that apply the selection protocol at early life stages, running the risk of a poor correlation of the trait with itself throughout the life cycle of individuals...
July 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29767680/propensity-for-adverse-pregnancy-outcomes-in-african-american-women-may-be-explained-by-low-energy-expenditure-in-early-pregnancy
#15
Jasper Most, L Anne Gilmore, Abby D Altazan, Marshall St Amant, Robbie A Beyl, Eric Ravussin, Leanne M Redman
Background: African-American (AA) women have poorer pregnancy outcomes and studies in nonpregnant women suggest a different etiology of weight gain in AA compared with white women. We hypothesized that physiologic factors such as low energy expenditure and physical activity would be present in AA compared with white women in pregnancy. Objective: We aimed to identify physiologic risk factors for disordered energy balance in AA and white women early in pregnancy...
May 14, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29767238/red-mulberry-fruit-aqueous-extract-and-silk-proteins-accelerate-acute-ethanol-metabolism-and-promote-the-anti%C3%A2-oxidant-enzyme-systems-in-rats
#16
Hye Jeong Yang, Min Jung Kim, Eun Seon Kang, Da Sol Kim, Sunmin Park
Red mulberry (Morus alba) fruit is rich in anthocyanins, and mulberry leaves are used by silk worms to make silk protein. We determined that the water and ethanol extract of mulberry fruit and silk amino acids accelerated ethanol degradation and suppressed temporal cognitive dysfunction in acute alcohol administered rats. The mechanism was explored in rats with acute oral administration of silk protein and mulberry fruit extracts. Rats were given 0.3 g of dextrin (control) and water extract (WMB) and ethanol extract of mulberry (EMB), silk protein hydrolysates (SKA), and a commercial product (positive‑control) based on body weight...
May 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29766773/effects-of-a-structured-physical-activity-program-on-habitual-physical-activity-and-body-composition-in-patients-with-chronic-kidney-disease-and-in-kidney-transplant-recipients
#17
Anna Masajtis-Zagajewska, Katarzyna Muras, Michał Nowicki
OBJECTIVES: In this study, we compared the effects of an individualized physical activity program on lifestyle, metabolic profile, body composition, and quality of life in kidney transplant recipients and patients with chronic kidney disease. MATERIALS AND METHODS: Our study included 24 kidney transplant recipients and 15 patients with chronic kidney disease at stage 3/4. Body composition (impedance spectroscopy) and habitual physical activity (accelerometry) assessed at baseline were used to prepare the individualized physical activity program...
May 16, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29766198/aquaporins-in-cancer-development-opportunities-for-bioinorganic-chemistry-to-contribute-novel-chemical-probes-and-therapeutic-agents
#18
REVIEW
Brech Aikman, Andreia de Almeida, Samuel M Meier-Menches, Angela Casini
Aquaporins (AQPs) are membrane proteins allowing permeation of water, glycerol & hydrogen peroxide across biomembranes, and playing an important role in water homeostasis in different organs, exocrine gland secretion, urine concentration, skin moisturization, fat metabolism and neural signal transduction. Notably, a large number of studies showed that AQPs are closely associated with cancer biological functions and expressed in more than 20 human cancer cell types. Furthermore, AQP expression is positively correlated with tumour types, grades, proliferation, migration, angiogenesis, as well as tumour-associated oedema, rendering these membrane channels attractive as both diagnostic and therapeutic targets in cancer...
May 16, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29765051/concurrent-and-orthogonal-gold-i-and-ruthenium-ii-catalysis-inside-living-cells
#19
Cristian Vidal, María Tomás-Gamasa, Paolo Destito, Fernando López, José L Mascareñas
The viability of building artificial metabolic pathways within a cell will depend on our ability to design biocompatible and orthogonal catalysts capable of achieving non-natural transformations. In this context, transition metal complexes offer unique possibilities to develop catalytic reactions that do not occur in nature. However, translating the potential of metal catalysts to living cells poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29764809/temperature-induced-physiological-stress-and-reproductive-characteristics-of-the-migratory-seahorse-hippocampus-erectus-during-a-thermal-stress-simulation
#20
Geng Qin, Cara Johnson, Yuan Zhang, Huixian Zhang, Jianping Yin, Glen Miller, Ralph G Turingan, Eric Guisbert, Qiang Lin
Inshore-offshore migration occurs frequently in seahorse species either because of prey opportunities or because it is driven by reproduction, and variations in water temperature may dramatically change migratory seahorse behavior and physiology. The present study investigated the behavioral and physiological responses of the lined seahorse Hippocampus erectus under thermal stress and evaluated the potential effects of different temperatures on its reproduction. The results showed that the thermal tolerance of the seahorses was time dependent...
May 15, 2018: Biology Open
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