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https://www.readbyqxmd.com/read/27913533/non-hodgkin-lymphoma-across-the-pediatric-and-adolescent-and-young-adult-age-spectrum
#1
John T Sandlund, Mike G Martin
The non-Hodgkin lymphomas (NHLs) occurring in children and adolescents and young adults (AYA) are characterized by various age-related differences in tumor biology and survival. Children generally present with high-grade lymphomas, such as Burkitt lymphoma, diffuse large B-cell lymphoma, lymphoblastic lymphoma, and anaplastic large cell lymphoma, whereas low-grade histologic subtypes, such as follicular lymphoma, occur more frequently with increasing age. Treatment outcome for children with NHL is generally superior to that observed in adults...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27903814/blink-associated-contralateral-eccentric-saccades-as-a-rare-sign-of-unilateral-brain-injury
#2
Ilaria Zivi, Eugenio Bertelli, Giacinta Bilotti, Ignazio Alessandro Clemente, Leopold Saltuari, Giuseppe Frazzitta
OBJECTIVE: To describe a rare sign of unilateral brain injury as a form of unwanted blink-associated contralateral eccentric saccades. METHODS: A 62-year-old patient who underwent an ischemic stroke affecting the entire right middle cerebral artery territory came to our attention 1 year after stroke, manifesting with transient contralateral conjugate gaze deviations associated with spontaneous blinking. We complemented the regular neurologic evaluation with brain MRI, study of evoked potentials, electroneurography of the facial nerve, and infrared video-oculoscopy...
November 30, 2016: Neurology
https://www.readbyqxmd.com/read/27898770/the-amaranth-genome-genome-transcriptome-and-physical-map-assembly
#3
J W Clouse, D Adhikary, J T Page, T Ramaraj, M K Deyholos, J A Udall, D J Fairbanks, E N Jellen, P J Maughan
Amaranth ( L.) is an emerging pseudocereal native to the New World that has garnered increased attention in recent years because of its nutritional quality, in particular its seed protein and more specifically its high levels of the essential amino acid lysine. It belongs to the Amaranthaceae family, is an ancient paleopolyploid that shows disomic inheritance (2 = 32), and has an estimated genome size of 466 Mb. Here we present a high-quality draft genome sequence of the grain amaranth. The genome assembly consisted of 377 Mb in 3518 scaffolds with an N of 371 kb...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27871643/neural-correlates-of-reward-processing-in-depressed-and-healthy-preschool-age-children
#4
Andy C Belden, Kelsey Irvin, Greg Hajcak, Emily S Kappenman, Danielle Kelly, Samantha Karlow, Joan L Luby, Deanna M Barch
OBJECTIVE: Adults and adolescents with major depressive disorder (MDD) show a blunted neural response to rewards. Depression has been validated in children as young as age 3; however, it remains unclear whether blunted response to reward is also a core feature of preschool-onset depression. If so, this would provide further validation for the continuity of the neural correlates of depression across the life span and would identify a potential target for treatment in young children. METHOD: Fifty-three 4- to 7-year-old children with depression and 25 psychiatrically healthy 4- to 7-year-old children completed a simple guessing task in which points could be won or lost on each trial while event-related potentials (ERPs) were recorded...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27869458/smith-and-lilienfeld-s-meta-analysis-of-the-response-modulation-hypothesis-important-theoretical-and-quantitative-clarifications
#5
Joseph P Newman, Arielle R Baskin-Sommers
In the first meta-analytic review of the response modulation hypothesis (RMH), an attention-based model for understanding the etiology of psychopathy, Smith and Lilienfeld (2015) report that the average effect size for response modulation deficits in psychopathic individuals fell in the small to medium range (r = .20; p < .001, d = .41). Moreover, support for the RMH extended to both psychopathy dimensions, applied across diverse assessments and settings, and spanned child, adult, female, and male samples...
December 2016: Psychological Bulletin
https://www.readbyqxmd.com/read/27864082/individual-variation-in-intentionality-in-the-mind-wandering-state-is-reflected-in-the-integration-of-the-default-mode-fronto-parietal-and-limbic-networks
#6
Johannes Golchert, Jonathan Smallwood, Elizabeth Jefferies, Paul Seli, Julia M Huntenburg, Franziskus Liem, Mark E Lauckner, Sabine Oligschläger, Boris C Bernhardt, Arno Villringer, Daniel S Margulies
Mind-wandering has a controversial relationship with cognitive control. Existing psychological evidence supports the hypothesis that episodes of mind-wandering reflect a failure to constrain thinking to task-relevant material, as well the apparently alternative view that control can facilitate the expression of self-generated mental content. We assessed whether this apparent contradiction arises because of a failure to consider differences in the types of thoughts that occur during mind-wandering, and in particular, the associated level of intentionality...
November 15, 2016: NeuroImage
https://www.readbyqxmd.com/read/27862862/variability-in-clinical-and-neuropsychological-features-of-individuals-with-map2k1-mutations
#7
Elizabeth I Pierpont, Margaret Semrud-Clikeman, Mary Ella Pierpont
Mutations in MAP2K1, a gene expressed within the RAS-mitogen activated protein kinase (RAS/MAPK) pathway, are generally associated with the clinical phenotype of cardiofaciocutaneous syndrome. Here we describe two male patients (ages 16 and 20 years) with mutations in MAP2K1 and heterogeneous clinical presentations. Both young men had short stature, some facial features suggesting a RASopathy and minimal cardiac involvement. Detailed medical and neuropsychological findings are presented alongside a comprehensive review of features of patients with MAP2K1 mutations reported in the literature...
November 14, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27862172/investigation-of-brain-electrophysiological-properties-among-heroin-addicts-quantitative-eeg-and-event-related-potentials
#8
Farid Motlagh, Fatimah Ibrahim, Rusdi Rashid, Tahereh Seghatoleslam, Hussain Habil
This study aims to introduce a new approach of a comprehensive paradigm to evaluate brain electrophysiological properties among addicts. Electroencephalographic spectral power as well as amplitudes and latencies of mismatch negativity (MMN), P300, and P600 components were evaluated among 19 male heroin addicts and 19 healthy nonsmoker subjects using a paradigm consisting of three subparadigms, namely (1) digit span Wechsler test, (2) auditory oddball, and (3) visual cue-reactivity oddball paradigms. Task 1 provided auditory P300 and P600 in association with working memory...
November 8, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27856335/examining-the-impact-of-grape-consumption-on-brain-metabolism-and-cognitive-function-in-patients-with-mild-decline-in-cognition-adouble-blinded-placebo-controlled-pilot-study
#9
Jooyeon Lee, Nare Torosyan, Daniel H Silverman
BACKGROUND: Natural compounds in grapes such as resveratrol are known for their antioxidant and anti-inflammatory properties. Some studies have shown a potential role for grapes or wine in slowing cognitive decline and other effects of aging. However, well-controlled experimental data obtained in human subjects are still in need of further development. Here we aimed to systemically assess effects of grapes on regional cerebral metabolism. METHODS: Ten subjects with mild decline in cognition (mean, 72...
November 14, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27854150/response-of-escherichia-coli-to-prolonged-berberine-exposure
#10
Nilay Budeyri Gokgoz, Fatma Gizem Avci, Kubra Karaosmanoglu Yoneten, Begum Alaybeyoglu, Elif Ozkirimli, Nihat Alpagu Sayar, Dilek Kazan, Berna Sariyar Akbulut
Berberine is a plant-derived alkaloid possessing antimicrobial activity; unfortunately, its efflux through multidrug resistance pumps reduces its efficacy. Cellular life span of Escherichia coli is generally shorter with prolonged berberine exposure; nevertheless, about 30% of the cells still remain robust following this treatment. To elucidate its mechanism of action and to identify proteins that could be involved in development of antimicrobial resistance, protein profiles of E. coli cells treated with berberine for 4...
November 17, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27853560/dynamics-and-biases-of-online-attention-the-case-of-aircraft-crashes
#11
Ruth García-Gavilanes, Milena Tsvetkova, Taha Yasseri
The Internet not only has changed the dynamics of our collective attention but also through the transactional log of online activities, provides us with the opportunity to study attention dynamics at scale. In this paper, we particularly study attention to aircraft incidents and accidents using Wikipedia transactional data in two different language editions, English and Spanish. We study both the editorial activities on and the viewership of the articles about airline crashes. We analyse how the level of attention is influenced by different parameters such as number of deaths, airline region, and event locale and date...
October 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27849609/temperature-response-of-soil-respiration-largely-unaltered-with-experimental-warming
#12
Joanna C Carey, Jianwu Tang, Pamela H Templer, Kevin D Kroeger, Thomas W Crowther, Andrew J Burton, Jeffrey S Dukes, Bridget Emmett, Serita D Frey, Mary A Heskel, Lifen Jiang, Megan B Machmuller, Jacqueline Mohan, Anne Marie Panetta, Peter B Reich, Sabine Reinsch, Xin Wang, Steven D Allison, Chris Bamminger, Scott Bridgham, Scott L Collins, Giovanbattista de Dato, William C Eddy, Brian J Enquist, Marc Estiarte, John Harte, Amanda Henderson, Bart R Johnson, Klaus Steenberg Larsen, Yiqi Luo, Sven Marhan, Jerry M Melillo, Josep Peñuelas, Laurel Pfeifer-Meister, Christian Poll, Edward Rastetter, Andrew B Reinmann, Lorien L Reynolds, Inger K Schmidt, Gaius R Shaver, Aaron L Strong, Vidya Suseela, Albert Tietema
The respiratory release of carbon dioxide (CO2) from soil is a major yet poorly understood flux in the global carbon cycle. Climatic warming is hypothesized to increase rates of soil respiration, potentially fueling further increases in global temperatures. However, despite considerable scientific attention in recent decades, the overall response of soil respiration to anticipated climatic warming remains unclear. We synthesize the largest global dataset to date of soil respiration, moisture, and temperature measurements, totaling >3,800 observations representing 27 temperature manipulation studies, spanning nine biomes and over 2 decades of warming...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27848005/neurocognitive-and-psychosocial-function-in-children-with-benign-external-hydrocephalus-beh-a-long-term-follow-up-study
#13
Rebecka Mikkelsen, Linn Nilsen Rødevand, Ulrikke Straume Wiig, Sverre Morten Zahl, Torhild Berntsen, Anne-Britt Skarbø, Arild Egge, Eirik Helseth, Stein Andersson, Knut Wester
INTRODUCTION: Long-term impact of benign external hydrocephalus (BEH) on cognition is largely unknown, and indication for neurosurgical CSF diversion procedure is debated. This study reports neuropsychological and psychosocial function in operated and non-operated BEH children. METHODS: Eighty-six children (76 males) between 8 and 18 years (mean 13.9) diagnosed with BEH before 12 months were included, of whom 30.2 % were operated. Participants completed neuropsychological tests and questionnaires covering quality of life (PedsQL) and executive function (BRIEF)...
November 15, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27826281/can-touch-screen-tablets-be-used-to-assess-cognitive-and-motor-skills-in-early-years-primary-school-children-a-cross-cultural-study
#14
Nicola J Pitchford, Laura A Outhwaite
Assessment of cognitive and motor functions is fundamental for developmental and neuropsychological profiling. Assessments are usually conducted on an individual basis, with a trained examiner, using standardized paper and pencil tests, and can take up to an hour or more to complete, depending on the nature of the test. This makes traditional standardized assessments of child development largely unsuitable for use in low-income countries. Touch screen tablets afford the opportunity to assess cognitive functions in groups of participants, with untrained administrators, with precision recording of responses, thus automating the assessment process...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27825957/dose-response-effects-of-water-supplementation-on-cognitive-performance-and-mood-in-children-and-adults
#15
Caroline J Edmonds, Laura Crosbie, Fareeha Fatima, Maryam Hussain, Nicole Jacob, Mark Gardner
Water supplementation has been found to facilitate visual attention and short-term memory, but the dose required to improve performance is not yet known. We assessed the dose response effect of water on thirst, mood and cognitive performance in both adults and children. Participants were offered either no water, 25 ml or 300 ml water to drink. Study 1 assessed 96 adults and in Study 2, data are presented from 60 children aged 7-9 years. In both studies, performance was assessed at baseline and 20 min after drinking (or no drink); on thirst and mood scales, letter cancellation and a digit span test...
November 5, 2016: Appetite
https://www.readbyqxmd.com/read/27825737/profile-of-cognitive-function-in-adults-with-duchenne-muscular-dystrophy
#16
Yukihiko Ueda, Shugo Suwazono, Sino Maedo, Itsuro Higuchi
BACKGROUND: Several studies have examined intellectual functioning of boys with duchenne muscular dystrophy (DMD). However, little is known about the remaining cognitive weaknesses in adults with DMD. OBJECTIVE: The purpose of this study was to investigate the profile of cognitive functioning that is characteristics of adults with DMD. METHODS: Twenty-four subscales from the Wechsler Adult Intelligence Scale III (WAIS-III), the Clinical Assessment for Attention (CAT), and the Wechsler Memory Scale Revised (WMS-R) were used to assess participants with DMD (N=15; mean age=30...
November 5, 2016: Brain & Development
https://www.readbyqxmd.com/read/27818232/the-genetics-of-exceptional-longevity-identifies-new-druggable-targets-for-vascular-protection-and-repair
#17
REVIEW
Annibale A Puca, Gaia Spinetti, Rosa Vono, Carmine Vecchione, Paolo Madeddu
Therapeutic angiogenesis is a relatively new medical strategy in the field of cardiovascular diseases. The underpinning concept is that angiogenic growth factors or proangiogenic cells could be exploited therapeutically in cardiovascular patients to enhance native revascularization responses to an ischemic insult, thereby accelerating tissue healing. The initial enthusiasm generated by preclinical studies has been tempered by the modest success of clinical trials assessing therapeutic angiogenesis. Similarly, proangiogenic cell therapy has so far not maintained the original promises...
November 3, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27810159/introduction-noncontraceptive-use-of-steroid-sex-hormones-in-reproductive-medicine
#18
Kurt T Barnhart
The use of estrogens and progestins in reproductive medicine is widespread and has spanned decades. Often the effect is therapeutic, but sometimes its use has unintended consequences. In this Views and Reviews, old and new indications for the use of ovarian sex steroids are examined with attention to updating knowledge, breaking bad habits, and providing evidence for use (or nonuse).
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27800180/cognitive-function-in-parkinson-s-disease-patients-with-and-without-anxiety
#19
K A Ehgoetz Martens, J Y Y Szeto, A J Muller, J M Hall, M Gilat, C C Walton, S J G Lewis
Research on the implications of anxiety in Parkinson's disease (PD) has been neglected despite its prevalence in nearly 50% of patients and its negative impact on quality of life. Previous reports have noted that neuropsychiatric symptoms impair cognitive performance in PD patients; however, to date, no study has directly compared PD patients with and without anxiety to examine the impact of anxiety on cognitive impairments in PD. This study compared cognitive performance across 50 PD participants with and without anxiety (17 PDA+; 33 PDA-), who underwent neurological and neuropsychological assessment...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27790099/cognitive-deficits-underlying-error-behavior-on-a-naturalistic-task-after-severe-traumatic-brain-injury
#20
Kathryn Hendry, Tamara Ownsworth, Elizabeth Beadle, Mathilde P Chevignard, Jennifer Fleming, Janelle Griffin, David H K Shum
People with severe traumatic brain injury (TBI) often make errors on everyday tasks that compromise their safety and independence. Such errors potentially arise from the breakdown or failure of multiple cognitive processes. This study aimed to investigate cognitive deficits underlying error behavior on a home-based version of the Cooking Task (HBCT) following TBI. Participants included 45 adults (9 females, 36 males) with severe TBI aged 18-64 years (M = 37.91, SD = 13.43). Participants were administered the HBCT in their home kitchens, with audiovisual recordings taken to enable scoring of total errors and error subtypes (Omissions, Additions, Estimations, Substitutions, Commentary/Questions, Dangerous Behavior, Goal Achievement)...
2016: Frontiers in Behavioral Neuroscience
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