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Mother milk

James Butcher, Sharon Unger, Jennifer Li, Nicole Bando, Guillaume Romain, Jane Francis, Walid Mottawea, David Mack, Alain Stintzi, Deborah L O'Connor
Background: Very-low-birth-weight (VLBW; born weighing <1500 g) infant feeding with mother's own milk (mother's milk) is associated with numerous beneficial health outcomes. Several interventions, including the prophylactic use of probiotics, are being adopted to promote a gastrointestinal microbiota favorable to the gut health of VLBW infants. An improved understanding of the microbiota that results from mother's milk feeding would therefore facilitate progress in this field. Objective: A preplanned primary objective of this research was to characterize the development of the gut microbiota in exclusively mother's milk-fed VLBW infants and describe the reference taxonomic profile that results from mother's milk feeding...
March 1, 2018: Journal of Nutrition
Elizabeth A Brownell, Adam P Matson, Kelsey C Smith, James E Moore, Patricia A Esposito, Mary M Lussier, Trudy J Lerer, James I Hagadorn
BACKGROUND: A dose-response relationship between proportions of donor human milk (DHM) intake and in-neonatal intensive care unit (in-NICU) growth rates, if any, remains poorly defined. Objective was to evaluate interrelationships between percentages of DHM, mother's own milk (MOM), and preterm formula (PF) intake and neonatal growth parameters at 36 weeks postmenstrual age or NICU discharge. METHODS: Infants eligible for this single-center retrospective study were inborn at ≤32 weeks gestation or ≤1800 g, stayed in the NICU for ≥7 days, and received enteral nutrition consisting of human milk fortified with Enfamil human milk fortifier acidified liquid...
March 14, 2018: Journal of Pediatric Gastroenterology and Nutrition
Jacqueline H Wolf
In the late 19th-century United States and Europe, infants died at high rates from diarrhea. Physicians and social justice advocates responded to the public health crisis with attempts to clean up the water and cows' milk supplies, as well as social welfare legislation and assorted educational efforts to help mothers better care for their children. Most visible among the educational efforts were breastfeeding campaigns. A century later in developing countries, physicians and activists were confronted with a similar problem-infants dying from diarrhea due to the unethical advertising and marketing practices of formula companies...
March 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
Ahmed Ragab Fakhreldin
Background: Breast milk adiponectin could play a role in the regulation of infants' growth during lactation. Aim of Work: The aim is to evaluate adiponectin concentration in human milk and to investigate its relationship with serum adiponectin concentration in lactating mothers and their breastfed infants and with anthropometric parameters of infants and mothers. Materials and Methods: Sixty healthy term infants and their healthy lactating mothers are included at infant age of 1 month then repeated again at the age of 4 months...
January 2018: Indian Journal of Endocrinology and Metabolism
Ángel Sánchez-Illana, Anna Parra-Llorca, Diana Escuder-Vieco, Carmen Rosa Pallás-Alonso, María Cernada, María Gormaz, Máximo Vento, Julia Kuligowski
Oxidative stress derived biomarkers have been extensively studied for assessing pathological situations in the neonatal period and their usefulness for an early outcome prediction of oxidative stress related diseases in non-invasive biofluids could be demonstrated. This is the first report on a method for the simultaneous detection of a panel of oxidative stress related biomarkers for quantifying damage to proteins and DNA in human breast milk samples. A straightforward sample clean-up procedure using 1.5 mL of milk was developed and extracts were analyzed by ultra-performance liquid chromatography coupled to tandem mass spectrometry...
August 3, 2018: Analytica Chimica Acta
Francesco Valitutti, Barbara De Santis, Chiara Maria Trovato, Monica Montuori, Simona Gatti, Salvatore Oliva, Carlo Brera, Carlo Catassi
OBJECTIVE: To assess the risk of mycotoxin exposure (aflatoxin M1, ochratoxin A, and zearalenone) in celiac disease (CD) breastfeeding mothers and healthy control mothers, as well as in their offspring, by quantifying these contaminants in breast milk. STUDY DESIGN: Thirty-five breastfeeding women with CD on a gluten-free diet and 30 healthy breastfeeding controls were recruited. Milk sampling was performed three times per day for three consecutive days. Mycotoxin content was investigated by an analytical method using immunoaffinity column clean-up and high-performance liquid chromatography (HPLC) with fluorometric detection...
March 10, 2018: Nutrients
Hoyce Amini Mshida, Neema Kassim, Emmanuel Mpolya, Martin Kimanya
Undernutrition among under-five children is a public health concern in developing countries and has been linked with poor water, sanitation and hygiene (WASH) practices. This study aimed at assessing WASH practices and its association with nutritional status of under-five children in semi-pastoral communities of Arusha. The study was cross-sectional in design. Mother-child pairs from 310 households in four villages of Monduli and Longido were involved. Weight and height of children were measured using weighing scale and length/height board, respectively...
March 12, 2018: American Journal of Tropical Medicine and Hygiene
Rachel M Burke, Paulina A Rebolledo, Anna M Aceituno, Rita Revollo, Volga Iñiguez, Mitchel Klein, Carolyn Drews-Botsch, Juan S Leon, Parminder S Suchdev
BACKGROUND: Iron deficiency (ID) is the most common micronutrient deficiency worldwide, with potentially severe consequences on child neurodevelopment. Though exclusive breastfeeding (EBF) is recommended for 6 months, breast milk has low iron content. This study aimed to estimate the effect of the length of EBF on iron status at 6 - 8 months of age among a cohort of Bolivian infants. METHODS: Mother-infant pairs were recruited from 2 hospitals in El Alto, Bolivia, and followed from one through 6 - 8 months of age...
March 12, 2018: BMC Pediatrics
Megan R Kwon, Eileen Cress, W Andrew Clark, Arsham Alamian, Yongke Lu, Jonathan M Peterson
Background: C1q TNF related protein 3 (CTRP3) is a relatively novel hormonal factor primarily derived from adipose tissue and has anti-diabetic properties. To determine if CTRP3 could play a role in early childhood development, the purpose of this study was to establish the presence of CTRP3 in breast milk (BM) and to determine whether CTRP3 levels were correlated with pregravid obesity status of the mother. Methods: Breast milk was collected from breast-feeding mothers who had a pregravid body mass index (BMI) classification of normal weight (BMI 18-25 kg/m2 , n = 23) or obese (BMI > 30 kg/m2 , n = 14)...
2018: PeerJ
Luke E Grzeskowiak, Catherine Leggett, Lynn Costi, Claire T Roberts, Lisa H Amir
AIMS: To examine the association between late pregnancy exposure to serotonin reuptake inhibitor (SRI) antidepressants and difficulties in achieving an adequate breast milk supply in women who gave birth to preterm infants, while accounting for the potential impacts of underlying maternal psychiatric illness. METHODS: Retrospective cohort study of 3,024 women delivering liveborn preterm infants (<37 weeks' gestation) between January 2004 and December 2008. The primary outcome was postnatal domperidone use, considered a valid proxy for presence and pharmacological management of low milk supply...
March 9, 2018: British Journal of Clinical Pharmacology
Adriana Moura Vieira, Poliana Guiomar de Almeida Brasiel, Maíra Schuchter Ferreira, Kacia Mateus, Mariana Sarto Figueiredo, Patrícia Cristina Lisboa, Egberto Gaspar de Moura, José Otavio do Amaral Corrêa, Fernando Cesar Ferraz Lopes, Paulo Henrique Fonseca da Silva, Céphora Maria Sabarense, Sheila Cristina Potente Luquetti Dutra, Aline Silva de Aguiar
PURPOSE: To evaluate the effects of maternal dietary soybean during lactation on the milk composition, body composition, lipid profile and glucose homeostasis of dams and offspring at weaning (21 days) and adulthood (150 days). METHODS: Lactating rats were divided into: casein control (C): casein diet; soy (S): soybean diet; soy oil control (SOC): casein diet, but with fat content similar to the S group. RESULTS: At 21 days, S mothers showed lower estradiol, total cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triglycerides (TG) in serum; and lower TC and TG in milk...
March 8, 2018: Endocrine
Luminiţa Păduraru, Daniela Cristina Dimitriu, Andreea Luciana Avasiloaiei, Mihaela Moscalu, Gabriela Ildiko Zonda, Maria Stamatin
BACKGROUND: Antioxidant defense of the body is assured by both endogenous and exogenous factors comprising several enzymes, vitamins, protein components and derivates and oligoelements. Breast milk has been proven to have important and essential antioxidant composition to prevent and protect against diseases in infancy. The objective of this study was to determine the total antioxidant status (TAS) of human milk and to evaluate the differences between premature milk and term milk at different moments of lactation (colostrum, transitional milk and mature milk)...
February 8, 2018: Pediatrics and Neonatology
M P Serrano, P Gambín, T Landete-Castillejos, A García, J Cappelli, F J Pérez-Barbería, J A Gómez, L Gallego
This study describes the effects of Mn supplementation of 20 late-gestating and lactating Iberian red deer (Cervuselaphushispanicus) females (hinds) fed a balanced diet on milk production and milk composition over the lactation period. Body weight of their calves at birth and at weaning was also evaluated. In addition, the effect of lactation stage was studied. For these purposes, 2 groups of hinds, one composed by 12 individuals (experimental) and the other by 8 individuals (control) were compared. Experimental hinds were s...
March 6, 2018: Journal of Animal Science
Melinda Fowler, Cory Champagne, Daniel Crocker
Animals that fast depend on mobilizing lipid stores to power metabolism. Northern elephant seals ( Mirounga angustirostris ) incorporate extended fasting into several life-history stages: development, molting, breeding and lactation. The physiological processes enabling fasting and lactation are important in the context of the ecology and life history of elephant seals. The rare combination of fasting and lactation depends on the efficient mobilization of lipid from adipose stores and its direction into milk production...
March 7, 2018: Journal of Experimental Biology
Josyf C Mychaleckyj, Uma Nayak, E Ross Colgate, Dadong Zhang, Tommy Carstensen, Shahnawaz Ahmed, Tahmeed Ahmed, Alexander J Mentzer, Masud Alam, Beth D Kirkpatrick, Rashidul Haque, Abu Syed Golam Faruque, William A Petri
BACKGROUND: Breast milk is the sole nutrition source during exclusive breastfeeding, and polyunsaturated fatty acids (FAs) are critical micronutrients in infant physical and cognitive development. There has been no prior genomewide association study of breast milk, hence our objective was to test for genetic association with breast milk FA composition. METHODS: We measured the fractional composition of 26 individual FAs in breast milk samples from three cohorts totalling 1142 Bangladeshi mothers whose infants were genotyped on the Illumina MEGA chip and replicated on a custom Affymetrix 30K SNP array (n=616)...
March 7, 2018: Journal of Medical Genetics
Mercedes Rubio, Mariona Bustamante, Carles Hernandez-Ferrer, Dietmar Fernandez-Orth, Lorena Pantano, Yaris Sarria, Maria Piqué-Borras, Kilian Vellve, Silvia Agramunt, Ramon Carreras, Xavier Estivill, Juan R Gonzalez, Alfredo Mayor
Circulating small RNAs, including miRNAs but also isomiRs and other RNA species, have the potential to be used as non-invasive biomarkers for communicable and non-communicable diseases. This study aims to characterize and compare small RNA profiles in human biofluids. For this purpose, RNA was extracted from plasma and breast milk samples from 15 healthy postpartum mothers. Small RNA libraries were prepared with the NEBNext® small RNA library preparation kit and sequenced in an Illumina HiSeq2000 platform...
2018: PloS One
Partosch Falko, Mielke Hans, Stahlmann Ralf, Gundert-Remy Ursula
Mycobacterial diseases remain a significant cause of morbidity and mortality worldwide. Rifampicin and ethambutol are among the drugs recommended by WHO as first line treatment. In this work, we addressed the question whether doses of the two anti-tuberculosis agents ethambutol and rifampicin transferred to a nursed infant could be of health concerns when the mother is under treatment. We used the approach of pharmacokinetic modelling using a structural model with two interconnected organisms, the first one being the organism of the nursing mother, the second one being the organism of the nursed child...
March 5, 2018: Basic & Clinical Pharmacology & Toxicology
Pantea Nazeri, Hosein Dalili, Yadollah Mehrabi, Mehdi Hedayati, Parvin Mirmiran, Fereidoun Azizi
Despite substantial progress in the global elimination of iodine deficiency, lactating mothers and their infants remain susceptible to insufficient iodine intake. This cross-sectional study was conducted to compare iodine statuses of breast-fed and formula-fed infants and their mothers at four randomly selected health care centres in Tehran. Healthy infants <3 months old and their mothers were randomly selected for inclusion in this study. Iodine was measured in urine and breast milk samples from each infant and mother as well as commercially available infant formula...
March 5, 2018: British Journal of Nutrition
Irene A Stafford, Eliza Rodrigue, Alexandra Berra, Wesley Adams, Asha J Heard, Joseph L Hagan, Shawn J Stafford
BACKGROUND: Necrotizing enterocolitis (NEC) is a leading cause of newborn gastrointestinal emergencies, affecting 1-3 per 1000 live births. Although NEC has been linked to a microbial etiology, associations with maternal intrapartum and resultant newborn early-onset invasive Group B streptococcus (EO-GBS) have been weakly defined. OBJECTIVE: The study aim was to determine the relationship between EO-GBS and NEC. STUDY DESIGN: Data from 2008 to 2015 were collected from pediatric records with ICD diagnosis codes consistent with all stages of NEC, with the exception of neonatal EO-GBS data (only available 2011-2015)...
February 24, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Hsiao-Ying Hung, Yu-Yun Hsu, Pei-Fang Su, Ying-Ju Chang
BACKGROUND: Human breastmilk provides the best nutrition for infants. When women or infants have difficulties in breastfeeding directly, breastmilk is usually pumped and frozen for later use. However, while frozen, breastmilk may develop a rancid flavor, which induces infant feeding stress and raises the mothers' concerns about the quality of frozen breastmilk. Nevertheless, few studies have investigated the variations in the compounds that cause the rancid flavor of breastmilk during frozen storage...
March 2, 2018: BMC Pediatrics
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