Qian Wu, Ana Rita Carlos, Faouzi Braza, Marie-Louise Bergman, Jamil Z Kitoko, Patricia Bastos-Amador, Eloy Cuadrado, Rui Martins, Bruna Sabino Oliveira, Vera C Martins, Brendon P Scicluna, Jonathan Jm Landry, Ferris E Jung, Temitope W Ademolue, Mirko Peitzsch, Jose Almeida-Santos, Jessica Thompson, Silvia Cardoso, Pedro Ventura, Manon Slot, Stamatia Rontogianni, Vanessa Ribeiro, Vital Da Silva Domingues, Inês A Cabral, Sebastian Weis, Marco Groth, Cristina Ameneiro, Miguel Fidalgo, Fudi Wang, Jocelyne Demengeot, Derk Amsen, Miguel P Soares
Regulatory T (TREG) cells develop via a program orchestrated by the transcription factor forkhead box protein P3 (FOXP3). Maintenance of the TREG cell lineage relies on sustained FOXP3 transcription via a mechanism involving demethylation of cytosine-phosphate-guanine (CpG)-rich elements at conserved non-coding sequences (CNS) in the FOXP3 locus. This cytosine demethylation is catalyzed by the ten-eleven translocation (TET) family of dioxygenases, and it involves a redox reaction that uses iron (Fe) as an essential cofactor...
March 18, 2024: EMBO Journal