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https://www.readbyqxmd.com/read/28080181/conceptualizing-patient-empowerment-in-cancer-follow-up-by-combining-theory-and-qualitative-data
#1
Anna Thit Johnsen, Nanna Bjerg Eskildsen, Thora Grothe Thomsen, Mogens Grønvold, Lone Ross, Clara R Jørgensen
BACKGROUND: Patient empowerment (PE) may be defined as the opportunity for patients to master issues important to their own health. The aim of this study was to conceptualize PE and how the concept manifests itself for cancer patients attending follow-up, in order to develop a relevant and sensitive questionnaire for this population. MATERIAL AND METHODS: A theoretical model of PE was made, based on Zimmerman's theory of psychological empowerment. Patients who were in follow-up after first line treatment for their cancer (n = 16) were interviewed about their experiences with follow-up...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28079984/medical-application-of-glycosaminoglycans-a-review
#2
REVIEW
Alexander Köwitsch, Guoying Zhou, Thomas Groth
The characteristic molecular composition of the different glycosaminoglycans (GAG) is related to their role as structural components and regulators of a multitude of functions of proteins, cells and tissues in the human body. Therefore, it is not surprising that GAG are widely used as coating materials for implants, components of 3D-constructs like tissue engineering scaffolds and hydrogels, but also as diagnostic devices like biosensors and in controlled release applications. Beside a physisorption or encapsulation of GAG, these applications often require their chemical modification to allow a stable covalent attachment on surfaces or cross-linking reactions with other molecules...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28077053/patient-empowerment-a-systematic-review-of-questionnaires-measuring-empowerment-in-cancer-patients
#3
Nanna Bjerg Eskildsen, Clara Ruebner Joergensen, Thora Grothe Thomsen, Lone Ross, Susanne Malchau Dietz, Mogens Groenvold, Anna Thit Johnsen
BACKGROUND: There is an increased attention to and demand for patient empowerment in cancer treatment and follow-up programs. Patient empowerment has been defined as feeling in control of or having mastery in relation to cancer and cancer care. This calls for properly developed questionnaires assessing empowerment from the user perspective. The aim of this review was to identify questionnaires and subscales measuring empowerment and manifestations of empowerment among cancer patients...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28065633/micronutrient-intake-is-inadequate-for-a-sample-of-pregnant-african-american-women
#4
Susan W Groth, Patricia A Stewart, Deborah J Ossip, Robert C Block, Nellie Wixom, I Diana Fernandez
BACKGROUND: Micronutrient intake is critical for fetal development and positive pregnancy outcomes. Little is known about the adequacy of micronutrient intake in pregnant African-American women. OBJECTIVE: To describe nutrient sufficiency and top food groups contributing to dietary intake of select micronutrients in low-income pregnant African-American women and determine whether micronutrient intake varies with early pregnancy body mass index (BMI) and/or gestational weight gain...
January 5, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28062720/multimodal-characterization-of-older-apoe2-carriers-reveals-selective-reduction-of-amyloid-load
#5
Michel J Grothe, Sylvia Villeneuve, Martin Dyrba, David Bartrés-Faz, Miranka Wirth
OBJECTIVE: To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach. METHODS: Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer's Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, and gray matter volume with structural MRI...
January 6, 2017: Neurology
https://www.readbyqxmd.com/read/28053344/histone-chaperone-networks-shaping-chromatin-function
#6
Colin M Hammond, Caroline B Strømme, Hongda Huang, Dinshaw J Patel, Anja Groth
The association of histones with specific chaperone complexes is important for their folding, oligomerization, post-translational modification, nuclear import, stability, assembly and genomic localization. In this way, the chaperoning of soluble histones is a key determinant of histone availability and fate, which affects all chromosomal processes, including gene expression, chromosome segregation and genome replication and repair. Here, we review the distinct structural and functional properties of the expanding network of histone chaperones...
January 5, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28051984/implementing-an-electronic-patient-based-orthopaedic-outcomes-system-factors-affecting-patient-participation-compliance
#7
John M Tokish, Jaime N Chisholm, Craig R Bottoni, Adam T Groth, Weichin Chen, Joseph R Orchowski
INTRODUCTION: Few studies have reported on the optimization of patient compliance within outcome registries and no studies exist on orthopaedic outcome registries in the military to date. Our aim is to report on the compliance rate of an electronic, web-based, patient-reported outcomes program, with particular emphasis on the effect of variables in data acquisition on survey compliance at a single military installation. METHODS: 1,814 patients were entered into the database allowing patients to complete subjective preoperative validated scores...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28045773/the-association-between-celiac-disease-and-eosinophilic-esophagitis-mayo-experience-and-meta-analysis-of-the-literature
#8
Salim Hommeida, Mouaz Alsawas, Mohammad H Murad, David A Katzka, Rayna M Grothe, Imad Absah
BACKGROUND: The association between celiac disease (CD) and eosinophilic esophagitis (EoE) has been the focus of multiple studies with variable results. Both diseases are immune mediated, and dietary triggers play a role in their pathogenesis. OBJECTIVES: The aim of the study was to analyze the risk of EoE in children with CD, assess the magnitude of association between CD and EoE in children, and report the characteristics and outcomes of children with both conditions...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28039094/petpve12-an-spm-toolbox-for-partial-volume-effects-correction-in-brain-pet-application-to-amyloid-imaging-with-av45-pet
#9
Gabriel Gonzalez-Escamilla, Catharina Lange, Stefan Teipel, Ralph Buchert, Michel J Grothe
Positron emission tomography (PET) allows detecting molecular brain changes in vivo. However, the accuracy of PET is limited by partial volume effects (PVE) that affects quantitative analysis and visual interpretation of the images. Although PVE-correction methods have been shown to effectively increase the correspondence of the measured signal with the true regional tracer uptake, these procedures are still not commonly applied, neither in clinical nor in research settings. Here, we present an implementation of well validated PVE-correction procedures as a SPM toolbox, PETPVE12, for automated processing...
December 28, 2016: NeuroImage
https://www.readbyqxmd.com/read/27993732/fast-therapeutic-dna-internalization-a-high-potential-transfection-system-based-on-a-peptide-mimicking-cationic-lipid
#10
Christopher Janich, Shashank Reddy Pinnapireddy, Frank Erdmann, Thomas Groth, Andreas Langner, Udo Bakowsky, Christian Wölk
The delivery of nucleic acids into cells is a determining factor for successful gene therapy. In this study we investigate the uptake and time dependent processing of a lipid-based non-viral nucleic acid delivery system composed of a peptide-mimicking cationic lipid (N-{6-amino-1-[N-(9Z)-octadec-9-enylamino]-1-oxohexan-(2S)-2-yl}-N'-{2-[N,N-bis(2-aminoethyl)amino]ethyl}-2-hexadecylpropandiamide - OH4) and a phospholipid (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine - DOPE). Studies by confocal laser scanning microscopy (CLSM) indicate a rapid internalization of fluorescent labelled DNA within 1h...
December 18, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27992676/heme-oxygenase-1-polymorphisms-can-affect-hcv-replication-and-treatment-responses-with-different-efficacy-in-humanized-mice
#11
Janine Kah, Tassilo Volz, Marc Lütgehetmann, Anne Groth, Ansgar W Lohse, Gisa Tiegs, Gabriele Sass, Maura Dandri
: Enhancement of host anti-oxidant enzymes, such as heme oxygenase-1, may attenuate virus-mediated hepatocyte injury, while the induction of HO-1 by cobalt-protoporphyrin-IX (CoPP) administration, as the application of its heme degradation product biliverdin (BV), was shown to hinder HCV replication in vitro. Additionally, (GT)n -repeats length in the polymorphic region of the HO-1 promoter may affect HO-1 expression and responsiveness to infection and disease severity. Aim of this study was to investigate the antiviral and hepatoprotective effects of CoPP-mediated HO-1 induction, alone or in combination with interferon alpha (peg-IFNα), in HCV-infected mice harboring hepatocytes from donors with different HO-1-promoter polymorphisms...
December 19, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27987824/synthesis-of-thiolated-polysaccharides-for-formation-of-polyelectrolyte-multilayers-with-improved-cellular-adhesion
#12
Pegah Esmaeilzadeh, Alexander Köwitsch, Frank Heyroth, Georg Schmidt, Steffen Fischer, Katja Richter, Thomas Groth
Intrinsic cross-linking is not only useful for increasing stability, but also for tailoring mechanical properties of polyelectrolyte multilayers (PEM) on implants and tissue engineering scaffolds. Here, a novel route for synthesizing thiolated chitosan (t-Chi) based on the application of 3,3'-dithiodipropionic acid was applied, while thiolated chondroitin sulfate (t-CS) was conjugated by 3,3'-dithiobis (propanoic hydrazide). Both products were subsequently reduced to obtain the free thiols. The thiol content, structural changes and degree of substitution were studied by UV-vis, FTIR, Raman and (1)H NMR spectroscopy, respectively...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27935808/evidence-on-methylphenidate-in-children-and-adolescents-with-adhd-is-in-fact-of-very-low-quality
#13
O J Storebø, M Zwi, H B Krogh, C R Moreira-Maia, M Holmskov, D Gillies, C Groth, E Simonsen, C Gluud
Banaschewski and colleagues from the European Attention Deficit Hyperactivity Disorder (ADHD) guideline group make a number of critical comments regarding our systematic review on methylphenidate for children and adolescents with ADHD. In this article, we present our views, showing that our trial selection was not flawed and was undertaken with scientific justification. Similarly, our data collection and interpretation was systematic and correct. We have followed a sound methodology for assessing risk of bias and our conclusions are not misleading...
November 2016: Evidence-based Mental Health
https://www.readbyqxmd.com/read/27927978/community-families-a-qualitative-study-of-families-who-volunteer-to-support-persons-with-severe-mental-illness
#14
Lotte Groth Jensen, Stina Lou, Jørgen Aagaard, Ulla Væggemose
BACKGROUND: Social interventions targeted at people with severe mental illness (SMI) often include volunteers. Volunteers' perspectives are important for these interventions to work. This article investigates the experiences of volunteer families who befriend a person with SMI. MATERIAL: Qualitative interviews with members of volunteer families. DISCUSSION: The families were motivated by helping a vulnerable person and by engaging in a rewarding relationship...
December 1, 2016: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/27921144/the-genetic-architecture-of-the-mhc-class-ii-region-in-british-texel-sheep
#15
Alsagher O A Ali, Abigail Stear, Karen Fairlie-Clarke, Gholamreza Nikbakht Brujeni, N Mahiza Md Isa, M Shahrom Bin Salisi, Katarzyna Donskow-Łysoniewska, David Groth, Johannes Buitkamp, Michael J Stear
Understanding the structure of the major histocompatibility complex, especially the number and frequency of alleles, loci and haplotypes, is crucial for efficient investigation of the way in which the MHC influences susceptibility to disease. Nematode infection is one of the most important diseases suffered by sheep, and the class II region has been repeatedly associated with differences in susceptibility and resistance to infection. Texel sheep are widely used in many different countries and are relatively resistant to infection...
December 5, 2016: Immunogenetics
https://www.readbyqxmd.com/read/27913612/mechanisms-in-endocrinology-skeletal-muscle-lipotoxicity-in-insulin-resistance-and-type-2-diabetes-a-causal-mechanism-or-an-innocent-bystander
#16
REVIEW
Charlotte Brøns, Louise Groth Grunnet
Dysfunctional adipose tissue is associated with an increased risk of developing type 2 diabetes (T2D). One characteristic of a dysfunctional adipose tissue is the reduced expandability of the subcutaneous adipose tissue leading to ectopic storage of fat in organs and/or tissues involved in the pathogenesis of T2D that can cause lipotoxicity. Accumulation of lipids in the skeletal muscle is associated with insulin resistance, but the majority of previous studies do not prove any causality. Most studies agree that it is not the intramuscular lipids per se that causes insulin resistance, but rather lipid intermediates such as diacylglycerols, fatty acyl-CoAs and ceramides and that it is the localization, composition and turnover of these intermediates that play an important role in the development of insulin resistance and T2D...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27909707/in-vitro-study-of-the-host-responses-to-model-biomaterials-via-a-fibroblast-macrophage-co-culture-system
#17
Guoying Zhou, Andrea Liedmann, Chandralekha Chatterjee, Thomas Groth
Surface properties are believed to play important roles in initial inflammatory and subsequent wound healing/fibrotic responses after implantation of biomaterials. To investigate the surface property effect in mediating these host responses, we used an in vitro fibroblast/macrophage co-culture model established with a cell migration chamber, and a series of self-assembling monolayers (SAMs) bearing different terminal groups as model surfaces to study the effect of surface properties on macrophage fusion, fibroblast attachment, spreading morphology, proliferation, outgrowth, as well as pro-(interleukin-6) and anti-(interleukin-10) inflammatory cytokine production, expression of ED-A fibronectin (FN) and alpha-smooth muscle actin (α-SMA)...
December 20, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27906200/evaluating-the-quality-of-marfan-genotype-phenotype-correlations-in-existing-fbn1-databases
#18
Kristian A Groth, Yskert Von Kodolitsch, Kerstin Kutsche, Mette Gaustadnes, Kasper Thorsen, Niels H Andersen, Claus H Gravholt
BACKGROUND: Genetic FBN1 testing is pivotal for confirming the clinical diagnosis of Marfan syndrome. In an effort to evaluate variant causality, FBN1 databases are often used. We evaluated the current databases regarding FBN1 variants and validated associated phenotype records with a new Marfan syndrome geno-phenotyping tool called the Marfan score. METHODS AND RESULTS: We evaluated four databases (UMD-FBN1, ClinVar, the Human Gene Mutation Database (HGMD), and Uniprot) containing 2,250 FBN1 variants supported by 4,904 records presented in 307 references...
December 1, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27892950/pd-1-checkpoint-blockade-in-patients-with-relapsed-aml-after-allogeneic-stem-cell-transplantation
#19
J C Albring, S Inselmann, T Sauer, C Schliemann, B Altvater, S Kailayangiri, C Rössig, W Hartmann, J R Knorrenschild, K Sohlbach, C Groth, M Lohoff, A Neubauer, W E Berdel, A Burchert, M Stelljes
No abstract text is available yet for this article.
November 28, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27878919/effect-of-health-status-on-fattening-performance-in-young-crossbred-polish-holstein-friesian-%C3%A3-limousin-bulls-and-steers
#20
Zofia Wielgosz-Groth, Monika Sobczuk-Szul, Zenon Nogalski, Paulina Pogorzelska-Przybyłek, Cezary Purwin
The aim of this study was to determine the effect of disease incidence on selected parameters of cattle fattening performance and carcass quality, and the fatty acid profile of beef. The experimental materials comprised 16 bulls and 16 steers, Polish Holstein-Friesian × Limousin crossbreeds (including 10 healthy and six treated animals of each category). At 5 weeks of age, bloodless castration was carried out using a rubber elastrator. The calves were fed milk replacer provided in automatic feeding stations...
November 23, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
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