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https://www.readbyqxmd.com/read/28334862/the-wilms-tumor-protein-wt1-contributes-to-female-fertility-by-regulating-oviductal-proteostasis
#1
Abinaya Nathan, Peter Reinhardt, Dagmar Kruspe, Tjard Jörß, Marco Groth, Hendrik Nolte, Andreas Habenicht, Jörg Herrmann, Verena Holschbach, Bettina Toth, Marcus Krüger, Zhao-Qi Wang, Matthias Platzer, Christoph Englert
Although the zinc finger transcription factor Wt1 has been linked to female fertility, its precise role in this process has not yet been understood. We have sequenced the WT1 exons in a panel of patients with idiopathic infertility and have identified a missense mutation in WT1 in one patient out of eight. This mutation leads to an amino acid change within the zinc finger domain and results in reduced DNA binding. We utilized Wt1+/- mice as a model to mechanistically pinpoint the consequences of reduced Wt1 levels for female fertility...
March 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28331430/measurement-of-the-production-cross-section-of-a-w%C3%A2-boson-in-association-with-two-b-jets-in-pp-collisions-at-formula-see-text
#2
V Khachatryan, A M Sirunyan, A Tumasyan, W Adam, E Asilar, T Bergauer, J Brandstetter, E Brondolin, M Dragicevic, J Erö, M Flechl, M Friedl, R Frühwirth, V M Ghete, C Hartl, N Hörmann, J Hrubec, M Jeitler, A König, I Krätschmer, D Liko, T Matsushita, I Mikulec, D Rabady, N Rad, B Rahbaran, H Rohringer, J Schieck, J Strauss, W Treberer-Treberspurg, W Waltenberger, C-E Wulz, V Mossolov, N Shumeiko, J Suarez Gonzalez, S Alderweireldt, E A De Wolf, X Janssen, J Lauwers, M Van De Klundert, H Van Haevermaet, P Van Mechelen, N Van Remortel, A Van Spilbeeck, S Abu Zeid, F Blekman, J D'Hondt, N Daci, I De Bruyn, K Deroover, N Heracleous, S Lowette, S Moortgat, L Moreels, A Olbrechts, Q Python, S Tavernier, W Van Doninck, P Van Mulders, I Van Parijs, H Brun, C Caillol, B Clerbaux, G De Lentdecker, H Delannoy, G Fasanella, L Favart, R Goldouzian, A Grebenyuk, G Karapostoli, T Lenzi, A Léonard, J Luetic, T Maerschalk, A Marinov, A Randle-Conde, T Seva, C Vander Velde, P Vanlaer, R Yonamine, F 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Tavolaro, K Theofilatos, R Wallny, T K Aarrestad, C Amsler, L Caminada, M F Canelli, A De Cosa, C Galloni, A Hinzmann, T Hreus, B Kilminster, C Lange, J Ngadiuba, D Pinna, G Rauco, P Robmann, D Salerno, Y Yang, V Candelise, T H Doan, Sh Jain, R Khurana, M Konyushikhin, C M Kuo, W Lin, Y J Lu, A Pozdnyakov, S S Yu, Arun Kumar, P Chang, Y H Chang, Y W Chang, Y Chao, K F Chen, P H Chen, C Dietz, F Fiori, W-S Hou, Y Hsiung, Y F Liu, R-S Lu, M Miñano Moya, E Paganis, A Psallidas, J F Tsai, Y M Tzeng, B Asavapibhop, G Singh, N Srimanobhas, N Suwonjandee, A Adiguzel, M N Bakirci, S Damarseckin, Z S Demiroglu, C Dozen, E Eskut, S Girgis, G Gokbulut, Y Guler, E Gurpinar, I Hos, E E Kangal, O Kara, U Kiminsu, M Oglakci, G Onengut, K Ozdemir, S Ozturk, A Polatoz, D Sunar Cerci, S Turkcapar, I S Zorbakir, C Zorbilmez, B Bilin, S Bilmis, B Isildak, G Karapinar, M Yalvac, M Zeyrek, E Gülmez, M Kaya, O Kaya, E A Yetkin, T Yetkin, A Cakir, K Cankocak, S Sen, B Grynyov, L Levchuk, P Sorokin, R Aggleton, F Ball, L Beck, J J Brooke, D Burns, E Clement, D Cussans, H Flacher, J Goldstein, M Grimes, G P Heath, H F Heath, J Jacob, L Kreczko, C Lucas, D M Newbold, S Paramesvaran, A Poll, T Sakuma, S Seif El Nasr-Storey, D Smith, V J Smith, K W Bell, A Belyaev, C Brew, R M Brown, L Calligaris, D Cieri, D J A Cockerill, J A Coughlan, K Harder, S Harper, E Olaiya, D Petyt, C H Shepherd-Themistocleous, A Thea, I R Tomalin, T Williams, M Baber, R Bainbridge, O Buchmuller, A Bundock, D Burton, S Casasso, M Citron, D Colling, L Corpe, P Dauncey, G Davies, A De Wit, M Della Negra, R Di Maria, P Dunne, A Elwood, D Futyan, Y Haddad, G Hall, G Iles, T James, R Lane, C Laner, R Lucas, L Lyons, A-M Magnan, S Malik, L Mastrolorenzo, J Nash, A Nikitenko, J Pela, B Penning, M Pesaresi, D M Raymond, A Richards, A Rose, C Seez, S Summers, A Tapper, K Uchida, M Vazquez Acosta, T Virdee, J Wright, S C Zenz, J E Cole, P R Hobson, A Khan, P Kyberd, D Leslie, I D Reid, P Symonds, L Teodorescu, M Turner, A Borzou, K Call, J Dittmann, K Hatakeyama, H Liu, N Pastika, O Charaf, S I Cooper, C Henderson, P Rumerio, D Arcaro, A Avetisyan, T Bose, D Gastler, D Rankin, C Richardson, J Rohlf, L Sulak, D Zou, G Benelli, E Berry, D Cutts, A Garabedian, J Hakala, U Heintz, J M Hogan, O Jesus, E Laird, G Landsberg, Z Mao, M Narain, S Piperov, S Sagir, E Spencer, R Syarif, R Breedon, G Breto, D Burns, M Calderon De La Barca Sanchez, S Chauhan, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, C Flores, G Funk, M Gardner, W Ko, R Lander, C Mclean, M Mulhearn, D Pellett, J Pilot, F Ricci-Tam, S Shalhout, J Smith, M Squires, D Stolp, M Tripathi, S Wilbur, R Yohay, R Cousins, P Everaerts, A Florent, J Hauser, M Ignatenko, D Saltzberg, E Takasugi, V Valuev, M Weber, K Burt, R Clare, J Ellison, J W Gary, G Hanson, J Heilman, P Jandir, E Kennedy, F Lacroix, O R Long, M Malberti, M Olmedo Negrete, M I Paneva, A Shrinivas, H Wei, S Wimpenny, B R Yates, J G Branson, G B Cerati, S Cittolin, M Derdzinski, R Gerosa, A Holzner, D Klein, V Krutelyov, J Letts, I Macneill, D Olivito, S Padhi, M Pieri, M Sani, V Sharma, S Simon, M Tadel, A Vartak, S Wasserbaech, C Welke, J Wood, F Würthwein, A Yagil, G Zevi Della Porta, R Bhandari, J Bradmiller-Feld, C Campagnari, A Dishaw, V Dutta, K Flowers, M Franco Sevilla, P Geffert, C George, F Golf, L Gouskos, J Gran, R Heller, J Incandela, N Mccoll, S D Mullin, A Ovcharova, J Richman, D Stuart, I Suarez, C West, J Yoo, D Anderson, A Apresyan, J Bendavid, A Bornheim, J Bunn, Y Chen, J Duarte, J M Lawhorn, A Mott, H B Newman, C Pena, M Spiropulu, J R Vlimant, S Xie, R Y Zhu, M B Andrews, V Azzolini, B Carlson, T Ferguson, M Paulini, J Russ, M Sun, H Vogel, I Vorobiev, J P Cumalat, W T Ford, F Jensen, A Johnson, M Krohn, T Mulholland, K Stenson, S R Wagner, J Alexander, J Chaves, J Chu, S Dittmer, K Mcdermott, N Mirman, G Nicolas Kaufman, J R Patterson, A Rinkevicius, A Ryd, L Skinnari, L Soffi, S M Tan, Z Tao, J Thom, J Tucker, P Wittich, M Zientek, D Winn, S Abdullin, M Albrow, G Apollinari, S Banerjee, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, G Bolla, K Burkett, J N Butler, H W K Cheung, F Chlebana, S Cihangir, M Cremonesi, V D Elvira, I Fisk, J Freeman, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, D Hare, R M Harris, S Hasegawa, J Hirschauer, Z Hu, B Jayatilaka, S Jindariani, M Johnson, U Joshi, B Klima, B Kreis, S Lammel, J Linacre, D Lincoln, R Lipton, T Liu, R Lopes De Sá, J Lykken, K Maeshima, N Magini, J M Marraffino, S Maruyama, D Mason, P McBride, P Merkel, S Mrenna, S Nahn, C Newman-Holmes, V O'Dell, K Pedro, O Prokofyev, G Rakness, L Ristori, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, S Stoynev, N Strobbe, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, M Wang, H A Weber, A Whitbeck, D Acosta, P Avery, P Bortignon, D Bourilkov, A Brinkerhoff, A Carnes, M Carver, D Curry, S Das, R D Field, I K Furic, J Konigsberg, A Korytov, P Ma, K Matchev, H Mei, P Milenovic, G Mitselmakher, D Rank, L Shchutska, D Sperka, L Thomas, J Wang, S Wang, J Yelton, S Linn, P Markowitz, G Martinez, J L Rodriguez, A Ackert, J R Adams, T Adams, A Askew, S Bein, B Diamond, S Hagopian, V Hagopian, K F Johnson, A Khatiwada, H Prosper, A Santra, M Weinberg, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, D Noonan, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, I Bucinskaite, R Cavanaugh, O Evdokimov, L Gauthier, C E Gerber, D J Hofman, P Kurt, C O'Brien, I D Sandoval Gonzalez, P Turner, N Varelas, H Wang, Z Wu, M Zakaria, J Zhang, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, H Mermerkaya, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, K Yi, I Anderson, B Blumenfeld, A Cocoros, N Eminizer, D Fehling, L Feng, A V Gritsan, P Maksimovic, M Osherson, J Roskes, U Sarica, M Swartz, M Xiao, Y Xin, C You, A Al-Bataineh, P Baringer, A Bean, J Bowen, C Bruner, J Castle, R P Kenny Iii, A Kropivnitskaya, D Majumder, W Mcbrayer, M Murray, S Sanders, R Stringer, J D Tapia Takaki, Q Wang, A Ivanov, K Kaadze, S Khalil, M Makouski, Y Maravin, A Mohammadi, L K Saini, N Skhirtladze, S Toda, D Lange, F Rebassoo, D Wright, C Anelli, A Baden, O Baron, A Belloni, B Calvert, S C Eno, C Ferraioli, J A Gomez, N J Hadley, S Jabeen, R G Kellogg, T Kolberg, J Kunkle, Y Lu, A C Mignerey, Y H Shin, A Skuja, M B Tonjes, S C Tonwar, D Abercrombie, B Allen, A Apyan, R Barbieri, A Baty, R Bi, K Bierwagen, S Brandt, W Busza, I A Cali, Z Demiragli, L Di Matteo, G Gomez Ceballos, M Goncharov, D Hsu, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, K Krajczar, Y S Lai, Y-J Lee, A Levin, P D Luckey, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, C Roland, G Roland, J Salfeld-Nebgen, G S F Stephans, K Sumorok, K Tatar, M Varma, D Velicanu, J Veverka, J Wang, T W Wang, B Wyslouch, M Yang, V Zhukova, A C Benvenuti, R M Chatterjee, A Evans, A Finkel, A Gude, P Hansen, S Kalafut, S C Kao, Y Kubota, Z Lesko, J Mans, S Nourbakhsh, N Ruckstuhl, R Rusack, N Tambe, J Turkewitz, J G Acosta, S Oliveros, E Avdeeva, R Bartek, K Bloom, S Bose, D R Claes, A Dominguez, C Fangmeier, R Gonzalez Suarez, R Kamalieddin, D Knowlton, I Kravchenko, A Malta Rodrigues, F Meier, J Monroy, J E Siado, G R Snow, B Stieger, M Alyari, J Dolen, J George, A Godshalk, C Harrington, I Iashvili, J Kaisen, A Kharchilava, A Kumar, A Parker, S Rappoccio, B Roozbahani, G Alverson, E Barberis, D Baumgartel, A Hortiangtham, A Massironi, D M Morse, D Nash, T Orimoto, R Teixeira De Lima, D Trocino, R-J Wang, D Wood, S Bhattacharya, K A Hahn, A Kubik, A Kumar, J F Low, N Mucia, N Odell, B Pollack, M H Schmitt, K Sung, M Trovato, M Velasco, N Dev, M Hildreth, K Hurtado Anampa, C Jessop, D J Karmgard, N Kellams, K Lannon, N Marinelli, F Meng, C Mueller, Y Musienko, M Planer, A Reinsvold, R Ruchti, G Smith, S Taroni, N Valls, M Wayne, M Wolf, A Woodard, J Alimena, L Antonelli, J Brinson, B Bylsma, L S Durkin, S Flowers, B Francis, A Hart, C Hill, R Hughes, W Ji, B Liu, W Luo, D Puigh, B L Winer, H W Wulsin, S Cooperstein, O Driga, P Elmer, J Hardenbrook, P Hebda, J Luo, D Marlow, T Medvedeva, K Mei, M Mooney, J Olsen, C Palmer, P Piroué, D Stickland, C Tully, A Zuranski, S Malik, A Barker, V E Barnes, S Folgueras, L Gutay, M K Jha, M Jones, A W Jung, K Jung, D H Miller, N Neumeister, B C Radburn-Smith, X Shi, J Sun, A Svyatkovskiy, F Wang, W Xie, L Xu, N Parashar, J Stupak, A Adair, B Akgun, Z Chen, K M Ecklund, F J M Geurts, M Guilbaud, W Li, B Michlin, M Northup, B P Padley, R Redjimi, J Roberts, J Rorie, Z Tu, J Zabel, B Betchart, A Bodek, P de Barbaro, R Demina, Y T Duh, T Ferbel, M Galanti, A Garcia-Bellido, J Han, O Hindrichs, A Khukhunaishvili, K H Lo, P Tan, M Verzetti, J P Chou, E Contreras-Campana, Y Gershtein, T A Gómez Espinosa, E Halkiadakis, M Heindl, D Hidas, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, S Kyriacou, A Lath, K Nash, H Saka, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, M Foerster, J Heideman, G Riley, K Rose, S Spanier, K Thapa, O Bouhali, A Celik, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Huang, E Juska, T Kamon, R Mueller, Y Pakhotin, R Patel, A Perloff, L Perniè, D Rathjens, A Rose, A Safonov, A Tatarinov, K A Ulmer, N Akchurin, C Cowden, J Damgov, C Dragoiu, P R Dudero, J Faulkner, S Kunori, K Lamichhane, S W Lee, T Libeiro, S Undleeb, I Volobouev, Z Wang, A G Delannoy, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, A Melo, H Ni, P Sheldon, S Tuo, J Velkovska, Q Xu, M W Arenton, P Barria, B Cox, J Goodell, R Hirosky, A Ledovskoy, H Li, C Neu, T Sinthuprasith, X Sun, Y Wang, E Wolfe, F Xia, C Clarke, R Harr, P E Karchin, P Lamichhane, J Sturdy, D A Belknap, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, M Herndon, A Hervé, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, I Ojalvo, T Perry, G A Pierro, G Polese, T Ruggles, A Savin, A Sharma, N Smith, W H Smith, D Taylor, N Woods
The production cross section of a W boson in association with two b jets is measured using a sample of proton-proton collisions at [Formula: see text] collected by the CMS experiment at the CERN LHC. The data sample corresponds to an integrated luminosity of 19.8[Formula: see text]. The W bosons are reconstructed via their leptonic decays, [Formula: see text], where [Formula: see text] or [Formula: see text]. The fiducial region studied contains exactly one lepton with transverse momentum [Formula: see text] and pseudorapidity [Formula: see text], with exactly two b jets with [Formula: see text] and [Formula: see text] and no other jets with [Formula: see text] and [Formula: see text]...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28330717/changes-in-motor-cortex-excitability-for-the-trained-and-non-trained-hand-after-long-term-unilateral-motor-training
#3
Matthias Grothe, Karla Doppl, Charlotte Roth, Sybille Roschka, Thomas Platz, Martin Lotze
Repetitive unilateral upper limb motor training does not only affect behavior but also increases excitability of the contralateral primary motor cortex (M1). The behavioral gain is partially transferred to the non-trained side. Changes in M1 intracortical facilitation (ICF) might as well be observed for both hand sides. We measured ICF of both left and right abductor pollicis brevis muscles (APB) before and after a two-week period of arm ability training (AAT) of the left hand in 13 strongly right handed healthy volunteers...
March 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28323018/modulation-of-auditory-percepts-by-transcutaneous-electrical-stimulation
#4
Margarete Anna Ueberfuhr, Amalia Braun, Lutz Wiegrebe, Benedikt Grothe, Markus Drexl
Transcutaneous, electrical stimulation with electrodes placed on the mastoid processes represents a specific way to elicit vestibular reflexes in humans without active or passive subject movements, for which the term galvanic vestibular stimulation was coined. It has been suggested that galvanic vestibular stimulation mainly affects the vestibular periphery, but whether vestibular hair cells, vestibular afferents, or a combination of both are excited, is still a matter of debate. Galvanic vestibular stimulation has been in use since the late 18(th) century, but despite the long-known and well-documented effects on the vestibular system, reports of the effect of electrical stimulation on the adjacent cochlea or the ascending auditory pathway are surprisingly sparse...
March 17, 2017: Hearing Research
https://www.readbyqxmd.com/read/28315501/mechanical-properties-and-biocompatibility-of-in-situ-enzymatically-cross-linked-gelatin-hydrogels
#5
Nada Z Alarake, Patrick Frohberg, Thomas Groth, Markus Pietzsch
OBJECTIVES: Gelatin, a degraded collagen, has been widely used as a scaffolding material in tissue engineering applications. In this work, we aimed at the development of in situ, cross-linking, cytocompatible hydrogels by the use of transglutaminase as a cross-linker for potential application in the regeneration of tissues. METHODS: Hydrogels were prepared from gelatin of different concentrations and bloom degree (175 (G175) or 300 (G300) bloom gelatin) and cross-linked with various amounts of microbial transglutaminase (mTG) at 37°C...
March 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28314702/short-term-outcomes-of-the-multi-institutional-bladder-exstrophy-consortium-successes-and-complications-in-the-first-two-years-of-collaboration
#6
J G Borer, E Vasquez, D A Canning, J V Kryger, A Bellows, D Weiss, T Groth, A Shukla, M P Kurtz, M E Mitchell
INTRODUCTION/BACKGROUND: Bladder exstrophy is a rare diagnosis that presents major reconstructive challenges. To increase experience and proficiency in the care of bladder exstrophy (BE), the Multi-Institutional BE Consortium (MIBEC) was formed, with a focus on refining technical aspects of complete primary repair of bladder exstrophy (CPRE) and subsequent care. OBJECTIVE: Outcome measures included successful CPRE (absence of dehiscence), complications, and integrated points of technique and care over the short-term...
February 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28306300/control-of-the-oscillatory-interlayer-exchange-interaction-with-terahertz-radiation
#7
Uta Meyer, Géraldine Haack, Christoph Groth, Xavier Waintal
The oscillatory interlayer exchange interaction between two magnetic layers separated by a metallic spacer is one of the few coherent quantum phenomena that persists at room temperature. Here, we show that this interaction can be controlled dynamically by illuminating the sample (e.g., a spin valve) with radiation in the 10-100 THz range. We predict that the exchange interaction can be changed from ferromagnetic to antiferromagnetic (and vice versa) by tuning the amplitude and/or the frequency of the radiation...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28293846/circular-dichroism-and-fluorescence-spectroscopy-to-study-protein-structure-and-protein-protein-interactions-in-ethylene-signaling
#8
Mareike Kessenbrock, Georg Groth
Circular dichroism (CD) spectroscopy is an invaluable technique to analyze secondary structure and functional folding of recombinant purified proteins. CD spectroscopy can also be applied to detect changes in protein secondary structure related to the pH or redox conditions found in different cellular compartments or to the interaction with other molecules. Another biophysical technique to monitor conformational changes and interaction with small molecule ligands or biological macromolecules is protein fluorescence spectroscopy making use of the aromatic amino acid tryptophan as a sensitive intrinsic fluorescent probe...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28290515/identification-of-accessory-olfactory-system-and-medial-amygdala-in-the-zebrafish
#9
Daniela Biechl, Kristin Tietje, Soojin Ryu, Benedikt Grothe, Gabriele Gerlach, Mario F Wullimann
Zebrafish larvae imprint on visual and olfactory cues of their kin on day 5 and 6 postfertilization, respectively. Only imprinted (but not non-imprinted) larvae show strongly activated crypt (and some microvillous) cells demonstrated by pERK levels after subsequent exposure to kin odor. Here, we investigate the olfactory bulb of zebrafish larvae for activated neurons located at the sole glomerulus mdG2 which receives crypt cell input. Imprinted larvae show a significantly increased activation of olfactory bulb cells compared to non-imprinted larvae after exposure to kin odor...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28289935/repeated-intravenous-administration-of-gadobutrol-does-not-lead-to-increased-signal-intensity-on-unenhanced-t1-weighted-images-a-voxel-based-whole-brain-analysis
#10
Soenke Langner, Marie-Luise Kromrey, Jens-Peter Kuehn, Matthias Grothe, Martin Domin
OBJECTIVES: To identify a possible association between repeated intravenous administration of gadobutrol and increased signal intensity in the grey and white matter using voxel-based whole-brain analysis. METHODS: In this retrospective single-centre study, 217 patients with a clinically isolated syndrome underwent baseline brain magnetic resonance imaging and at least one annual follow-up examination with intravenous administration of 0.1 mmol/kg body weight of gadobutrol...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28284865/total-synthesis-and-antileukemic-evaluations-of-the-phenazine-5-10-dioxide-natural-products-iodinin-myxin-and-their-derivatives
#11
Elvar Örn Viktorsson, Bendik Melling Grøthe, Reidun Aesoy, Misbah Sabir, Simen Snellingen, Anthony Prandina, Ove Alexander Høgmoen Åstrand, Tore Bonge-Hansen, Stein Ove Døskeland, Lars Herfindal, Pål Rongved
A new efficient total synthesis of the phenazine 5,10-dioxide natural products iodinin and myxin and new compounds derived from them was achieved in few steps, a key-step being 1,6-dihydroxyphenazine di-N-oxidation. Analogues prepared from iodinin, including myxin and 2-ethoxy-2-oxoethoxy derivatives, had fully retained cytotoxic effect against human cancer cells (MOLM-13 leukemia) at atmospheric and low oxygen level. Moreover, iodinin was for the first time shown to be hypoxia selective. The structure-activity relationship for leukemia cell death induction revealed that the level of N-oxide functionality was essential for cytotoxicity...
February 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28277600/materials-surfaces-and-systems-for-extracorporeal-therapies-and-beyond
#12
Viktoria Weber, Thomas Groth
No abstract text is available yet for this article.
March 7, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28264342/settling-the-name-i-diomedea-i-i-exulans-i-linnaeus-1758-for-the-wandering-albatross-by-neotypification
#13
Richard Schodde, Alan J D Tennyson, Jeff G Groth, Jonas Lai, Paul Scofield, Frank D Steinheimer
On-going conflict in use of the name Diomedea exulans Linnaeus, 1758 for different taxa of the great albatrosses (Wandering Albatross complex) is resolved by neotypification, fixing the name to the large subantarctic form formerly often known as D. chionoptera Salvin, 1896. Application of all scientific names in the complex is reviewed, an annotated synonymy for the large subantarctic form is provided, available names for smaller, temperate-zone forms are listed, and unavailable and otherwise invalid names referable to the complex are identified...
February 21, 2017: Zootaxa
https://www.readbyqxmd.com/read/28260978/measurements-of-the-formula-see-text-production-cross-section-in-lepton-jets-final-states-in-pp-collisions-at-8-formula-see-text-and-ratio-of-8-to-7%C3%A2-formula-see-text-cross-sections
#14
V Khachatryan, A M Sirunyan, A Tumasyan, W Adam, E Asilar, T Bergauer, J Brandstetter, E Brondolin, M Dragicevic, J Erö, M Flechl, M Friedl, R Frühwirth, V M Ghete, C Hartl, N Hörmann, J Hrubec, M Jeitler, V Knünz, A König, M Krammer, I Krätschmer, D Liko, T Matsushita, I Mikulec, D Rabady, B Rahbaran, H Rohringer, J Schieck, R Schöfbeck, J Strauss, W Treberer-Treberspurg, W Waltenberger, C-E Wulz, V Mossolov, N Shumeiko, J Suarez Gonzalez, S Alderweireldt, T Cornelis, E A De Wolf, X Janssen, A Knutsson, J Lauwers, S Luyckx, M Van De Klundert, H Van Haevermaet, P Van Mechelen, N Van Remortel, A Van Spilbeeck, S Abu Zeid, F Blekman, J D'Hondt, N Daci, I De Bruyn, K Deroover, N Heracleous, J Keaveney, S Lowette, M Maes, L Moreels, A Olbrechts, Q Python, D Strom, S Tavernier, W Van Doninck, P Van Mulders, G P Van Onsem, I Van Parijs, P Barria, H Brun, C Caillol, B Clerbaux, G De Lentdecker, G Fasanella, L Favart, A Grebenyuk, G Karapostoli, T Lenzi, A Léonard, T Maerschalk, A Marinov, L Perniè, A Randle-Conde, T Reis, T Seva, C Vander Velde, P Vanlaer, R Yonamine, F Zenoni, F Zhang, K Beernaert, L Benucci, A Cimmino, S Costantini, S Crucy, D Dobur, A Fagot, G Garcia, M Gul, J Mccartin, A A Ocampo Rios, D Poyraz, D Ryckbosch, S Salva, M Sigamani, N Strobbe, M Tytgat, W Van Driessche, E Yazgan, N Zaganidis, S Basegmez, C Beluffi, O Bondu, S Brochet, G Bruno, A Caudron, L Ceard, G G Da Silveira, C Delaere, D Favart, L Forthomme, A Giammanco, J Hollar, A Jafari, P Jez, M Komm, V Lemaitre, A Mertens, M Musich, C Nuttens, L Perrini, A Pin, K Piotrzkowski, A Popov, L Quertenmont, M Selvaggi, M Vidal Marono, N Beliy, G H Hammad, W L Aldá Júnior, F L Alves, G A Alves, L Brito, M Correa Martins Junior, M Hamer, C Hensel, C Mora Herrera, A Moraes, M E Pol, P Rebello Teles, E Belchior Batista Das Chagas, W Carvalho, J Chinellato, A Custódio, E M Da Costa, D De Jesus Damiao, C De Oliveira Martins, S Fonseca De Souza, L M Huertas Guativa, H Malbouisson, D Matos Figueiredo, L Mundim, H Nogima, W L Prado Da Silva, A Santoro, A Sznajder, E J Tonelli Manganote, A Vilela Pereira, S Ahuja, C A Bernardes, A De Souza Santos, S Dogra, T R Fernandez Perez Tomei, E M Gregores, P G Mercadante, C S Moon, S F Novaes, Sandra S Padula, D Romero Abad, J C Ruiz Vargas, A Aleksandrov, R Hadjiiska, P Iaydjiev, M Rodozov, S Stoykova, G Sultanov, M Vutova, A Dimitrov, I Glushkov, L Litov, B Pavlov, P Petkov, M Ahmad, J G Bian, G M Chen, H S Chen, M Chen, T Cheng, R Du, C H Jiang, R Plestina, F Romeo, S M Shaheen, A Spiezia, J Tao, C Wang, Z Wang, H Zhang, C Asawatangtrakuldee, Y Ban, Q Li, S Liu, Y Mao, S J Qian, D Wang, Z Xu, C Avila, A Cabrera, L F Chaparro Sierra, C Florez, J P Gomez, B Gomez Moreno, J C Sanabria, N Godinovic, D Lelas, I Puljak, P M Ribeiro Cipriano, Z Antunovic, M Kovac, V Brigljevic, K Kadija, J Luetic, S Micanovic, L Sudic, A Attikis, G Mavromanolakis, J Mousa, C Nicolaou, F Ptochos, P A Razis, H Rykaczewski, M Bodlak, M Finger, M Finger, A A Abdelalim, A 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Pesaresi, K Petridis, D M Raymond, A Richards, A Rose, C Seez, A Tapper, K Uchida, M Vazquez Acosta, T Virdee, S C Zenz, J E Cole, P R Hobson, A Khan, P Kyberd, D Leggat, D Leslie, I D Reid, P Symonds, L Teodorescu, M Turner, A Borzou, K Call, J Dittmann, K Hatakeyama, H Liu, N Pastika, O Charaf, S I Cooper, C Henderson, P Rumerio, D Arcaro, A Avetisyan, T Bose, C Fantasia, D Gastler, P Lawson, D Rankin, C Richardson, J Rohlf, J St John, L Sulak, D Zou, J Alimena, E Berry, S Bhattacharya, D Cutts, N Dhingra, A Ferapontov, A Garabedian, J Hakala, U Heintz, E Laird, G Landsberg, Z Mao, M Narain, S Piperov, S Sagir, R Syarif, R Breedon, G Breto, M Calderon De La Barca Sanchez, S Chauhan, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, M Gardner, W Ko, R Lander, M Mulhearn, D Pellett, J Pilot, F Ricci-Tam, S Shalhout, J Smith, M Squires, D Stolp, M Tripathi, S Wilbur, R Yohay, R Cousins, P Everaerts, C Farrell, J Hauser, M Ignatenko, D Saltzberg, E Takasugi, V Valuev, M Weber, K Burt, R Clare, J Ellison, J W Gary, G Hanson, J Heilman, M Ivova Paneva, P Jandir, E Kennedy, F Lacroix, O R Long, A Luthra, M Malberti, M Olmedo Negrete, A Shrinivas, H Wei, S Wimpenny, B R Yates, J G Branson, G B Cerati, S Cittolin, R T D'Agnolo, M Derdzinski, A Holzner, R Kelley, D Klein, J Letts, I Macneill, D Olivito, S Padhi, M Pieri, M Sani, V Sharma, S Simon, M Tadel, A Vartak, S Wasserbaech, C Welke, F Würthwein, A Yagil, G Zevi Della Porta, J Bradmiller-Feld, C Campagnari, A Dishaw, V Dutta, K Flowers, M Franco Sevilla, P Geffert, C George, F Golf, L Gouskos, J Gran, J Incandela, N Mccoll, S D Mullin, J Richman, D Stuart, I Suarez, C West, J Yoo, D Anderson, A Apresyan, A Bornheim, J Bunn, Y Chen, J Duarte, A Mott, H B Newman, C Pena, M Pierini, M Spiropulu, J R Vlimant, S Xie, R Y Zhu, M B Andrews, V Azzolini, A Calamba, B Carlson, T Ferguson, M Paulini, J Russ, M Sun, H Vogel, I Vorobiev, J P Cumalat, W T Ford, A Gaz, F Jensen, A Johnson, M Krohn, T Mulholland, U Nauenberg, K Stenson, S R Wagner, J Alexander, A Chatterjee, J Chaves, J Chu, S Dittmer, N Eggert, N Mirman, G Nicolas Kaufman, J R Patterson, A Rinkevicius, A Ryd, L Skinnari, L Soffi, W Sun, S M Tan, W D Teo, J Thom, J Thompson, J Tucker, Y Weng, P Wittich, S Abdullin, M Albrow, J Anderson, G Apollinari, S Banerjee, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, G Bolla, K Burkett, J N Butler, H W K Cheung, F Chlebana, S Cihangir, V D Elvira, I Fisk, J Freeman, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, J Hanlon, D Hare, R M Harris, S Hasegawa, J Hirschauer, Z Hu, B Jayatilaka, S Jindariani, M Johnson, U Joshi, A W Jung, B Klima, B Kreis, S Kwan, S Lammel, J Linacre, D Lincoln, R Lipton, T Liu, R Lopes De Sá, J Lykken, K Maeshima, J M Marraffino, V I Martinez Outschoorn, S Maruyama, D Mason, P McBride, P Merkel, K Mishra, S Mrenna, S Nahn, C Newman-Holmes, V O'Dell, K Pedro, O Prokofyev, G Rakness, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, H A Weber, A Whitbeck, F Yang, D Acosta, P Avery, P Bortignon, D Bourilkov, A Carnes, M Carver, D Curry, S Das, G P Di Giovanni, R D Field, I K Furic, S V Gleyzer, J Hugon, J Konigsberg, A Korytov, J F Low, P Ma, K Matchev, H Mei, P Milenovic, G Mitselmakher, D Rank, R Rossin, L Shchutska, M Snowball, D Sperka, N Terentyev, L Thomas, J Wang, S Wang, J Yelton, S Hewamanage, S Linn, P Markowitz, G Martinez, J L Rodriguez, A Ackert, J R Adams, T Adams, A Askew, J Bochenek, B Diamond, J Haas, S Hagopian, V Hagopian, K F Johnson, A Khatiwada, H Prosper, M Weinberg, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, H Kalakhety, D Noonan, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, I Bucinskaite, R Cavanaugh, O Evdokimov, L Gauthier, C E Gerber, D J Hofman, P Kurt, C O'Brien, I D Sandoval Gonzalez, C Silkworth, P Turner, N Varelas, Z Wu, M Zakaria, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, H Mermerkaya, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, K Yi, I Anderson, B A Barnett, B Blumenfeld, N Eminizer, D Fehling, L Feng, A V Gritsan, P Maksimovic, C Martin, M Osherson, J Roskes, A Sady, U Sarica, M Swartz, M Xiao, Y Xin, C You, P Baringer, A Bean, G Benelli, C Bruner, R P Kenny, D Majumder, M Malek, M Murray, S Sanders, R Stringer, Q Wang, A Ivanov, K Kaadze, S Khalil, M Makouski, Y Maravin, A Mohammadi, L K Saini, N Skhirtladze, S Toda, D Lange, F Rebassoo, D Wright, C Anelli, A Baden, O Baron, A Belloni, B Calvert, S C Eno, C Ferraioli, J A Gomez, N J Hadley, S Jabeen, R G Kellogg, T Kolberg, J Kunkle, Y Lu, A C Mignerey, Y H Shin, A Skuja, M B Tonjes, S C Tonwar, A Apyan, R Barbieri, A Baty, K Bierwagen, S Brandt, W Busza, I A Cali, Z Demiragli, L Di Matteo, G Gomez Ceballos, M Goncharov, D Gulhan, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, Y S Lai, Y-J Lee, A Levin, P D Luckey, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, D Ralph, C Roland, G Roland, J Salfeld-Nebgen, G S F Stephans, K Sumorok, M Varma, D Velicanu, J Veverka, J Wang, T W Wang, B Wyslouch, M Yang, V Zhukova, B Dahmes, A Evans, A Finkel, A Gude, P Hansen, S Kalafut, S C Kao, K Klapoetke, Y Kubota, Z Lesko, J Mans, S Nourbakhsh, N Ruckstuhl, R Rusack, N Tambe, J Turkewitz, J G Acosta, S Oliveros, E Avdeeva, K Bloom, S Bose, D R Claes, A Dominguez, C Fangmeier, R Gonzalez Suarez, R Kamalieddin, J Keller, D Knowlton, I Kravchenko, F Meier, J Monroy, F Ratnikov, J E Siado, G R Snow, M Alyari, J Dolen, J George, A Godshalk, C Harrington, I Iashvili, J Kaisen, A Kharchilava, A Kumar, S Rappoccio, B Roozbahani, G Alverson, E Barberis, D Baumgartel, M Chasco, A Hortiangtham, A Massironi, D M Morse, D Nash, T Orimoto, R Teixeira De Lima, D Trocino, R-J Wang, D Wood, J Zhang, K A Hahn, A Kubik, N Mucia, N Odell, B Pollack, A Pozdnyakov, M Schmitt, S Stoynev, K Sung, M Trovato, M Velasco, A Brinkerhoff, N Dev, M Hildreth, C Jessop, D J Karmgard, N Kellams, K Lannon, S Lynch, N Marinelli, F Meng, C Mueller, Y Musienko, T Pearson, M Planer, A Reinsvold, R Ruchti, G Smith, S Taroni, N Valls, M Wayne, M Wolf, A Woodard, L Antonelli, J Brinson, B Bylsma, L S Durkin, S Flowers, A Hart, C Hill, R Hughes, W Ji, K Kotov, T Y Ling, B Liu, W Luo, D Puigh, M Rodenburg, B L Winer, H W Wulsin, O Driga, P Elmer, J Hardenbrook, P Hebda, S A Koay, P Lujan, D Marlow, T Medvedeva, M Mooney, J Olsen, C Palmer, P Piroué, H Saka, D Stickland, C Tully, A Zuranski, S Malik, V E Barnes, D Benedetti, D Bortoletto, L Gutay, M K Jha, M Jones, K Jung, D H Miller, N Neumeister, B C Radburn-Smith, X Shi, I Shipsey, D Silvers, J Sun, A Svyatkovskiy, F Wang, W Xie, L Xu, N Parashar, J Stupak, A Adair, B Akgun, Z Chen, K M Ecklund, F J M Geurts, M Guilbaud, W Li, B Michlin, M Northup, B P Padley, R Redjimi, J Roberts, J Rorie, Z Tu, J Zabel, B Betchart, A Bodek, P de Barbaro, R Demina, Y Eshaq, T Ferbel, M Galanti, A Garcia-Bellido, J Han, A Harel, O Hindrichs, A Khukhunaishvili, G Petrillo, P Tan, M Verzetti, S Arora, A Barker, J P Chou, C Contreras-Campana, E Contreras-Campana, D Duggan, D Ferencek, Y Gershtein, R Gray, E Halkiadakis, D Hidas, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, A Lath, K Nash, S Panwalkar, M Park, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, M Foerster, G Riley, K Rose, S Spanier, A York, O Bouhali, A Castaneda Hernandez, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Kamon, V Krutelyov, R Mueller, I Osipenkov, Y Pakhotin, R Patel, A Perloff, A Rose, A Safonov, A Tatarinov, K A Ulmer, N Akchurin, C Cowden, J Damgov, C Dragoiu, P R Dudero, J Faulkner, S Kunori, K Lamichhane, S W Lee, T Libeiro, S Undleeb, I Volobouev, E Appelt, A G Delannoy, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, Y Mao, A Melo, H Ni, P Sheldon, B Snook, S Tuo, J Velkovska, Q Xu, M W Arenton, B Cox, B Francis, J Goodell, R Hirosky, A Ledovskoy, H Li, C Lin, C Neu, T Sinthuprasith, X Sun, Y Wang, E Wolfe, J Wood, F Xia, C Clarke, R Harr, P E Karchin, C Kottachchi Kankanamge Don, P Lamichhane, J Sturdy, D A Belknap, D Carlsmith, M Cepeda, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, R Hall-Wilton, M Herndon, A Hervé, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, A Mohapatra, I Ojalvo, T Perry, G A Pierro, G Polese, T Ruggles, T Sarangi, A Savin, A Sharma, N Smith, W H Smith, D Taylor, N Woods
A measurement of the top quark pair production ([Formula: see text]) cross section in proton-proton collisions at the centre-of-mass energy of 8[Formula: see text] is presented using data collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 19.6[Formula: see text]. This analysis is performed in the [Formula: see text] decay channels with one isolated, high transverse momentum electron or muon and at least four jets, at least one of which is required to be identified as originating from hadronization of a b quark...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28243860/upper-gastrointestinal-endoscopy-prior-to-bariatric-surgery-mandatory-or-expendable-an-analysis-of-801-cases
#15
Stefan Wolter, Anna Duprée, Jameel Miro, Cornelia Schroeder, Marie-Isabelle Jansen, Clarissa Schulze-Zur-Wiesch, Stefan Groth, Jakob Izbicki, Oliver Mann, Philipp Busch
BACKGROUND: Upper gastrointestinal pathologies are common in bariatric patients. Preoperative esophagogastroduodenal endoscopy (EGD) should detect and treat pathologies that might alter the type of bariatric surgery. However, clinical consequences of these findings are often insignificant. The aim of this study was to assess the influence of preoperative endoscopy in our cohort and its clinical consequences. METHODS: We conducted a retrospective analysis of endoscopic findings in patients under evaluation for bariatric surgery...
February 27, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28238738/reference-standard-space-hippocampus-labels-according-to-the-eadc-adni-harmonized-protocol-utility-in-automated-volumetry
#16
Dominik Wolf, Martina Bocchetta, Gregory M Preboske, Marina Boccardi, Michel J Grothe
BACKGROUND: A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. METHODS: Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels...
February 23, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28222208/effect-of-thiolated-glycosaminoglycans-on-the-behavior-of-breast-cancer-cells-toward-the-development-of-in-vitro-models-of-cancer
#17
Alexander Köwitsch, Ankur Chhalotre, Thomas Groth
PURPOSE: The influence of extracellular matrix components like glycosaminoglycans (GAG) or adhesive proteins on the migration of cancer cells and the progression of tumorigenesis remains a challenging task. Therefore, this study aims to give insight into the interaction of cancer cells exhibiting different metastatic potential (MDA-MB-231, MDA-MB-468) with surface immobilized GAG interacting with serum proteins like fibronectin. METHODS: Model substrata were covalently coated with different thiolated GAG (hyaluronan (HA), chondroitin sulfate (CS), heparin (Hep)) and investigated for the adsorption of fibronectin (FN) with surface plasmon resonance...
February 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28205351/functional-assessment-of-the-kidneys-in-a-10%C3%A2-month-old-child-with-renal-artery-stenosis-by-intravoxel-incoherent-motion
#18
Jochen Herrmann, Harald Ittrich, Michael Gerhard Kaul, Michael Groth, Magdalini Tozakidou, Martin Blohm, Jun Oh, Gerhard Adam
Renovascular stenosis is an important cause for arterial hypertension in childhood. We report a 10-month-old girl with arterial hypertension caused by right-sided renal artery stenosis detected by Doppler ultrasound. Magnetic resonance imaging (MRI) was performed before renal artery angioplasty to depict vascular anatomy in detail and to retrieve additional functional information of the kidneys by analysis of intravoxel incoherent motion (IVIM). The value of quantitative diffusion weighted imaging of the kidneys prior to percutaneous transluminal renal angioplasty (PTRA) is discussed...
March 2017: Nephrology
https://www.readbyqxmd.com/read/28193895/p53-regulates-the-cardiac-transcriptome
#19
Tak W Mak, Ludger Hauck, Daniela Grothe, Filio Billia
The tumor suppressor Trp53 (p53) inhibits cell growth after acute stress by regulating gene transcription. The mammalian genome contains hundreds of p53-binding sites. However, whether p53 participates in the regulation of cardiac tissue homeostasis under normal conditions is not known. To examine the physiologic role of p53 in adult cardiomyocytes in vivo, Cre-loxP-mediated conditional gene targeting in adult mice was used. Genome-wide transcriptome analyses of conditional heart-specific p53 knockout mice were performed...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28193224/microrna-mir-29-controls-a-compensatory-response-to-limit-neuronal-iron-accumulation-during-adult-life-and-aging
#20
Roberto Ripa, Luca Dolfi, Marco Terrigno, Luca Pandolfini, Aurora Savino, Valeria Arcucci, Marco Groth, Eva Terzibasi Tozzini, Mario Baumgart, Alessandro Cellerino
BACKGROUND: A widespread modulation of gene expression occurs in the aging brain, but little is known as to the upstream drivers of these changes. MicroRNAs emerged as fine regulators of gene expression in many biological contexts and they are modulated by age. MicroRNAs may therefore be part of the upstream drivers of the global gene expression modulation correlated with aging and aging-related phenotypes. RESULTS: Here, we show that microRNA-29 (miR-29) is induced during aging in short-lived turquoise killifish brain and genetic antagonism of its function induces a gene-expression signature typical of aging...
February 13, 2017: BMC Biology
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