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Christian Groth, Kravitz D Neal, Jeffrey M Shirck
No abstract text is available yet for this article.
January 2018: Journal of Clinical Orthodontics: JCO
Kravitz D Neal, Christian Groth, Tom Shannon
No abstract text is available yet for this article.
January 2018: Journal of Clinical Orthodontics: JCO
Ingrid Charlotte Andersen, Thora Grothe Thomsen, Poul Bruun, Uffe Bødtger, Lise Hounsgaard
BACKGROUND: Patient-family-healthcare provider interaction seems important for patients with chronic obstructive pulmonary disease (COPD) and their family members' self-management practices. Because the need for support might be enhanced after a hospitalisation, it might be beneficial to explore this interaction further in follow-up health care. AIM: To explore the meaning of patients' and their family members' experiences of interacting with healthcare providers to their daily self-management over time...
February 15, 2018: Scandinavian Journal of Caring Sciences
R Paul Boesch, Karthik Balakrishnan, Sari Acra, Dan T Benscoter, Shelagh A Cofer, Joseph M Collaco, John P Dahl, Cori L Daines, Alessandro DeAlarcon, Emily M DeBoer, Robin R Deterding, Joel A Friedlander, Benjamin D Gold, Rayna M Grothe, Catherine K Hart, Mikhail Kazachkov, Maureen A Lefton-Greif, Claire Kane Miller, Paul E Moore, Scott Pentiuk, Stacey Peterson-Carmichael, Joseph Piccione, Jeremy D Prager, Philip E Putnam, Rachel Rosen, Michael J Rutter, Matthew J Ryan, Margaret L Skinner, Cherie Torres-Silva, Christopher T Wootten, Karen B Zur, Robin T Cotton, Robert E Wood
Aerodigestive programs provide coordinated interdisciplinary care to pediatric patients with complex congenital or acquired conditions affecting breathing, swallowing, and growth. Although there has been a proliferation of programs, as well as national meetings, interest groups and early research activity, there is, as of yet, no consensus definition of an aerodigestive patient, standardized structure, and functions of an aerodigestive program or a blueprint for research prioritization. The Delphi method was used by a multidisciplinary and multi-institutional panel of aerodigestive providers to obtain consensus on 4 broad content areas related to aerodigestive care: (1) definition of an aerodigestive patient, (2) essential construct and functions of an aerodigestive program, (3) identification of aerodigestive research priorities, and (4) evaluation and recognition of aerodigestive programs and future directions...
February 7, 2018: Pediatrics
Michio Nagata
PURPOSE OF REVIEW: Earlier works of the glomerulogenesis described morphological steps and protein expression during in-vivo and in-vitro kidney development. Recent technologies using cell-specific or conditional knock-out mice for several factors provide important knowledge about cross-talk signaling among resident cells as local events. Based on the recent advancement, this review revisits comprehensive morphological development of the glomerulus. RECENT FINDINGS: Interactions of presumptive podocyte vascular endothelial growth factor with vascular endothelial growth factor-2 on angioblasts initiate glomerular vascularization...
February 9, 2018: Current Opinion in Nephrology and Hypertension
Christopher L Groth, Brian D Berman
Background: Spinocerebellar ataxia (SCA) is an uncommon form of progressive cerebellar ataxia with multiple genetic causes and marked variability in phenotypic expression even across patients with identical genetic abnormalities. SCA27 is a recently identified SCA caused by mutations in the Fibroblast Growth Factor 14 gene, with a phenotypic expression that is only beginning to be fully appreciated. We report here a case of a 70-year-old male who presented with slowly worsening tremor and gait instability that began in his early adulthood along with additional features of parkinsonism on examination...
2018: Tremor and Other Hyperkinetic Movements
Christine M Groth, Nicole M Acquisto, Tina Khadem
PURPOSE: Characterize medication practices during and immediately after rapid sequence intubation (RSI) by provider/location and evaluate adverse drug events. MATERIALS AND METHODS: This was a multicenter, observational, cross-sectional study of adult and pediatric intensive care unit and emergency department patients over a 24-h period surrounding first intubation. RESULTS: A total of 404 patients from 34 geographically diverse institutions were included (mean age 58 ± 22 years, males 59%, pediatric 8%)...
January 30, 2018: Journal of Critical Care
Mathieu Pioche, Angelique Denis, Hans-Dieter Allescher, Gianluca Andrisani, Guido Costamagna, Evelien Dekker, Paul Fockens, Christian Gerges, Stefan Groth, Jennis Kandler, Isabelle Lienhart, Horst Neuhaus, Lucio Petruzziello, Guido Schachschal, Kristien Tytgat, Jürgen Wallner, Vincens Weingart, Sandrine Touzet, Thierry Ponchon, Thomas Rösch
BACKGROUND AND AIMS: Numerous randomized studies have shown that changing certain features of colonoscopes, usually incorporated when switching from one endoscope generation to the next, mostly do not increase adenoma yield. There is, however, indirect evidence that it may be necessary to skip one instrument generation (ie, changing from one generation to the next but one) to achieve this effect. METHODS: We compared the latest-generation colonoscopes from one company (Olympus Exera III, 190-C) with the next to last one (Olympus 160/5-C) in a prospective multicenter study randomized for the order of colonoscopes in a tandem fashion, involving 2 different examiners...
January 30, 2018: Gastrointestinal Endoscopy
Ivayla Apostolova, Catharina Lange, Anja Mäurer, Per Suppa, Lothar Spies, Michel J Grothe, Till Nierhaus, Jochen B Fiebach, Elisabeth Steinhagen-Thiessen, R Buchert
Structural deterioration and volume loss of the hippocampal formation is observed in many diseases associated with memory decline. Paradoxically, glucose metabolism of the hippocampal formation can be increased at the same time. This might be a consequence of compensatory (beneficial) or maladaptive (detrimental) mechanisms. Aim of this study was to differentiate between compensation and maladaptation by analyzing the association between glucose metabolism in the hippocampal formation measured by positron emission tomography with the glucose analogue 18F-fluorodeoxyglucose and cognitive performance as characterized by the extended Consortium to Establish a Registry for Alzheimer's Disease test battery in a sample of 87 patients (81...
January 31, 2018: Neurobiology of Aging
Sheila Krogh-Jespersen, Zsuzsa Kaldy, Annalisa Groth Valadez, Alice S Carter, Amanda L Woodward
This study examined the predictive reasoning abilities of typically developing (TD) infants and 2-year-old children with autism spectrum disorder (ASD) in an eye-tracking paradigm. Participants watched a video of a goal-directed action in which a human actor reached for and grasped one of two objects. At test, the objects switched locations. Across these events, we measured: visual anticipation of the action outcome with kinematic cues (i.e., a completed reaching behavior); goal prediction of the action outcome without kinematic cues (i...
February 5, 2018: Autism Research: Official Journal of the International Society for Autism Research
Ida Siveke, Julian J Ammer, Sarah A Gleiss, Benedikt Grothe, Christian Leibold, Felix Felmy
In sensory systems the neuronal representation of external stimuli is enhanced along the sensory pathway. In the auditory system, strong enhancement of binaural information takes place between the brainstem and the midbrain, however the underlying cellular mechanisms are unknown. Here we investigated the transformation of binaural information in the dorsal nucleus of the lateral lemniscus (DNLL), a nucleus that connects the binaural nuclei in the brainstem and the inferior colliculus in the midbrain. We used in vitro and in vivo electrophysiology in adult Mongolian gerbils to show that NMDARs play a critical role in neuronal encoding of stimulus properties in the DNLL...
February 6, 2018: European Journal of Neuroscience
Tenielle Porter, Samantha C Burnham, Vincent Doré, Greg Savage, Pierrick Bourgeat, Kimberly Begemann, Lidija Milicic, David Ames, Ashley I Bush, Paul Maruff, Colin L Masters, Christopher C Rowe, Stephanie Rainey-Smith, Ralph N Martins, David Groth, Giuseppe Verdile, Victor L Villemagne, Simon M Laws
A single nucleotide polymorphism, rs17070145, in the KIdney and BRAin expressed protein (KIBRA) gene has been associated with cognition and hippocampal volume in cognitively normal (CN) individuals. However, the impact of rs17070145 on longitudinal cognitive decline and hippocampal atrophy in CN adults at greatest risk of developing Alzheimer's disease is unknown. We investigated the impact rs17070145 has on the rate of cognitive decline and hippocampal atrophy over six years in 602 CN adults, with known brain Aβ-amyloid levels and whether there is an interactive effect with APOE genotype...
February 1, 2018: Scientific Reports
Michael Groth, Käthe Greta Barthe, Martin Riemer, Marielle Ernst, Jochen Herrmann, Jens Fiehler, Jan-Hendrik Buhk
PURPOSE:  To compare the learning benefit of three different teaching strategies on the interpretation of emergency cerebral computed tomography (CT) pathologies by medical students. MATERIALS AND METHODS:  Three groups of students with different types of teaching (e-learning, interactive teaching, and standard curricular education in neuroradiology) were tested with respect to the detection of seven CT pathologies. The test results of each group were compared for each CT pathology using the chi-square test...
February 1, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Veit Herklotz, Aleš Kovařík, Jana Lunerová, Susan Lippitsch, Marco Groth, Christiane M Ritz
Dogroses represent an exceptional system for studying the effects of genome doubling and hybridization: their asymmetrical meiosis enables recombination in bi-parentally inherited chromosomes but prevents it in maternally inherited ones. We employed fluorescent in situ hybridization, genome skimming, amplicon sequencing of genomic and cDNA as well as conventional cloning of nuclear ribosomal DNA in two phylogenetically distinct pentaploid (2n = 5x = 35) species, Rosa canina and R. inodora, and their naturally occurring reciprocal hybrids, R...
January 31, 2018: Plant Journal: for Cell and Molecular Biology
Peer Aramillo Irizar, Sascha Schäuble, Daniela Esser, Marco Groth, Christiane Frahm, Steffen Priebe, Mario Baumgart, Nils Hartmann, Shiva Marthandan, Uwe Menzel, Julia Müller, Silvio Schmidt, Volker Ast, Amke Caliebe, Rainer König, Michael Krawczak, Michael Ristow, Stefan Schuster, Alessandro Cellerino, Stephan Diekmann, Christoph Englert, Peter Hemmerich, Jürgen Sühnel, Reinhard Guthke, Otto W Witte, Matthias Platzer, Eytan Ruppin, Christoph Kaleta
Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcriptomic signature of ageing based on gene expression data from four vertebrate species across four tissues. We find that ageing-associated transcriptomic changes follow trajectories similar to the transcriptional alterations observed in degenerative ageing diseases but are in opposite direction to the transcriptomic alterations observed in cancer...
January 30, 2018: Nature Communications
Julie Kueppers, Karen Farchaus Stein, Susan Groth, I Diana Fernandez
BACKGROUND: Mothers play a key role in shaping the dietary intake of their young children through their own dietary intake and the foods they make available at home. Therefore, understanding the mechanisms underlying maternal food choices is crucial. Cognitions about the self as a healthy eater, referred to as healthy-eater self-schema (HESS), predict dietary intake in diverse samples, but the linkage has not been investigated in mothers and their feeding behaviors. This study examined the relationship between a maternal HESS, maternal and child intake of fruits, vegetables, saturated fat, and added sugar, and home food availability...
January 27, 2018: Appetite
Wanlu Liu, Sascha H Duttke, Jonathan Hetzel, Martin Groth, Suhua Feng, Javier Gallego-Bartolome, Zhenhui Zhong, Hsuan Yu Kuo, Zonghua Wang, Jixian Zhai, Joanne Chory, Steven E Jacobsen
Small RNAs regulate chromatin modifications such as DNA methylation and gene silencing across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24-nucleotide small interfering RNAs (siRNAs) that bind to ARGONAUTE 4 (AGO4) and target genomic regions for silencing. RdDM also requires non-coding RNAs transcribed by RNA polymerase V (Pol V) that probably serve as scaffolds for binding of AGO4-siRNA complexes. Here, we used a modified global nuclear run-on protocol followed by deep sequencing to capture Pol V nascent transcripts genome-wide...
January 29, 2018: Nature Plants
Falk Hillmann, Gillian Forbes, Silvia Novohradská, Iuliia Ferling, Konstantin Riege, Marco Groth, Martin Westermann, Manja Marz, Thomas Spaller, Thomas Winckler, Pauline Schaap, Gernot Glöckner
Establishment of multicellularity represents a major transition in eukaryote evolution. A subgroup of Amoebozoa, the dictyosteliids, has evolved a relatively simple aggregative multicellular stage resulting in a fruiting body supported by a stalk. Protosteloid amoeba, which are scattered throughout the amoebozoan tree, differ by producing only one or few single stalked spores. Thus, one obvious difference in the developmental cycle of protosteliids and dictyosteliids seems to be the establishment of multicellularity...
January 25, 2018: Genome Biology and Evolution
Malte Selch Larsen, Rasmus Vestergaard Juul, Andreas Velsing Groth, Ulrika S H Simonsson, Annemarie T Kristensen, Tom Knudsen, Henrik Agersø, Mads Kreilgaard
Various experimental animal models are used in haemophilia research, however, little is known about how well the different species predict pharmacokinetic (PK) profiles in haemophilia patients. The aim of the current study was to describe the plasma concentration-time profile of recombinant activated factor VII (rFVIIa) and recombinant factor VIII (rFVIII) in several experimental animal models using population PK modelling, and apply a simulation-based approach to evaluate how well the developed animal population PK models predict human PK...
January 21, 2018: European Journal of Pharmaceutical Sciences
Hady Razak Hady, Magdalena Olszewska, Mikolaj Czerniawski, Dawid Groth, Inna Diemieszczyk, Patrycja Pawluszewicz, Adam Kretowski, Jerzy Robert Ladny, Jacek Dadan
Obesity is a growing health, social, and economic issue and became an epidemic, according to recent report of World Health Organization.The only method with scientifically proved efficiency of body mass loss is a surgical treatment. Laparoscopic sleeve gastrectomy (LSG) is recently a leading method in metabolic surgery. There are no standards of operative technique for LSG so far. The influence of technique modification on metabolic effect has not been described clearly.The aim of this study was to evaluate metabolic effects in patients with morbid obesity who underwent various surgical approaches of LSG...
January 2018: Medicine (Baltimore)
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