Arthur Barcelos Ribeiro, Matheus Reis Santos de Melo, Marcela de Melo Junqueira, Mônica Garcia Leal Rodrigues, Thiago Olimpio de Souza, Gabriela Fernandes, Mário Ferreira Conceição Santos, Sérgio Ricardo Ambrósio, Jairo Kenupp Bastos, Denise Crispim Tavares
Melanoma, an aggressive and potentially fatal skin cancer, is constrained by immunosuppression, resistance, and high toxicity in its treatment. Consequently, there is an urgent need for innovative antineoplastic agents. Therefore, this study investigated the antimelanoma potential of guttiferone E (GE). In an allogeneic murine B16 melanoma model, GE was administered subcutaneously and intraperitoneally. Antitumor evaluation included tumor volume/weight measurements and histopathological and immunohistochemical analysis...
January 25, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology