Hao Zuo, Jinseo Park, Aurel Frangaj, Jianxiang Ye, Guanqi Lu, Jamie J Manning, Wesley B Asher, Zhengyuan Lu, Guo-Bin Hu, Liguo Wang, Joshua Mendez, Edward Eng, Zhening Zhang, Xin Lin, Robert Grassucci, Wayne A Hendrickson, Oliver B Clarke, Jonathan A Javitch, Arthur D Conigrave, Qing R Fan
The human calcium-sensing receptor (CaSR) detects fluctuations in the extracellular Ca2+ concentration and maintains Ca2+ homeostasis1,2 . It also mediates diverse cellular processes not associated with Ca2+ balance3-5 . The functional pleiotropy of CaSR arises in part from its ability to signal through several G-protein subtypes6 . We determined structures of CaSR in complex with G proteins from three different subfamilies: Gq , Gi and Gs . We found that the homodimeric CaSR of each complex couples to a single G protein through a common mode...
April 17, 2024: Nature