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https://www.readbyqxmd.com/read/28713853/factors-associated-with-acute-postoperative-pain-following-breast-reconstruction
#1
Anita R Kulkarni, Andrea L Pusic, Jennifer B Hamill, Hyungjin M Kim, Ji Qi, Edwin G Wilkins, Randy S Roth
INTRODUCTION: Post-mastectomy breast reconstruction has become an increasingly important component of breast cancer treatment. Unfortunately, some patients experience severe postoperative pain, placing them at risk for increased clinical morbidity and the development of disabling chronic pain. In an attempt to identify at-risk patients, we prospectively evaluated patient characteristics and medical/surgical variables associated with more severe acute post-reconstruction pain. METHODS: Women (N = 2207; one-week 82...
March 2017: JPRAS Open
https://www.readbyqxmd.com/read/28709680/patient-satisfaction-with-laser-sintered-removable-partial-dentures-a-crossover-pilot-clinical-trial
#2
Balqees Almufleh, Elham Emami, Omar Alageel, Fabiana de Melo, Francois Seng, Eric Caron, Samer Abi Nader, Ashwaq Al-Hashedi, Rubens Albuquerque, Jocelyne Feine, Faleh Tamimi
STATEMENT OF PROBLEM: Clinical data regarding newly introduced laser-sintered removable partial dentures (RPDs) are needed before this technique can be recommended. Currently, only a few clinical reports have been published, with no clinical studies. PURPOSE: This clinical trial compared short-term satisfaction in patients wearing RPDs fabricated with conventional or computer-aided design and computer-aided manufacturing (CAD-CAM) laser-sintering technology. MATERIAL AND METHODS: Twelve participants with partial edentulism were enrolled in this pilot crossover double-blinded clinical trial...
July 11, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28693329/a-novel-approach-to-improving-patient-experience-in-orthopedics
#3
Spencer M Stein, Sarav S Shah, Alanna Carcich, Marlena McGill, Isaac Gammal, Michael Langino, Thomas Mauri
The patient experience domain comprises a significant portion of the Hospital Value-Based Purchasing program. This study investigated whether an intervention focusing on attending physician awareness, resident and physician assistant education, and multidisciplinary patient-centric care had an effect on patient perceived physician communication and overall hospital ratings. Responses to the Hospital Consumer Assessment of Healthcare Providers and Systems survey were reviewed in 2014 and 2015. Patients' perceptions that the physician explained their condition in ways they understood and the overall hospital rating improved significantly after implantation of the model ( P < ...
February 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28684100/automaticity-of-force-application-during-simulated-brain-tumor-resection-testing-the-fitts-and-posner-model
#4
Abdulgadir Bugdadi, Robin Sawaya, Duaa Olwi, Gmaan Al-Zhrani, Hamed Azarnoush, Abdulrahman Jafar Sabbagh, Ghusn Alsideiri, Khalid Bajunaid, Fahad E Alotaibi, Alexander Winkler-Schwartz, Rolando Del Maestro
OBJECTIVE: The Fitts and Posner model of motor learning hypothesized that with deliberate practice, learners progress through stages to an autonomous phase of motor ability. To test this model, we assessed the automaticity of neurosurgeons, senior residents, and junior residents when operating on 2 identical tumors using the NeuroVR virtual reality simulation platform. DESIGN: Participants resected 9 identical simulated tumors on 2 occasions (total = 18 resections)...
July 3, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28670914/high-prevalence-of-chronic-pain-with-neuropathic-characteristics-after-open-reduction-and-internal-fixation-of-ankle-fractures
#5
Nadia Rbia, Cornelis H van der Vlies, Berry I Cleffken, Ruud W Selles, Steven E R Hovius, Tim H J Nijhuis
BACKGROUND: Unstable ankle fractures require treatment with open reduction and internal fixation (ORIF). Long-term functional outcome is satisfying in most patients; however, a number of patients have persistent complaints. Superficial nerve complications following ankle surgery may be the cause of chronic pain and disability. METHODS: In this observational retrospective survey, a cohort of 527 women and men, who underwent ORIF in the period from January 2007 to January 2014, were invited to an online questionnaire...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28643399/distributed-health-literacy-among-people-living-with-type-2-diabetes-in-portugal-defining-levels-of-awareness-and-support
#6
Liliana Abreu, João Arriscado Nunes, Peter Taylor, Susana Silva
This study embraces a patient-centred and narrative-oriented notion of health literacy, exploring how social networks and personal experiences constitute distributed health literacy (DHL) by mapping out health literacy mediators of each individual and how they enable self-management skills and knowledge of health conditions. Semi-structured interviews with 26 patients with type 2 diabetes were conducted in a Primary Care Center of Porto (Portugal) from October 2014 to December 2015. Data were collected based on McGill Illness Narrative Interview (MINI)...
June 22, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28542317/systematic-review-of-dietary-salt-reduction-policies-evidence-for-an-effectiveness-hierarchy
#7
Lirije Hyseni, Alex Elliot-Green, Ffion Lloyd-Williams, Chris Kypridemos, Martin O'Flaherty, Rory McGill, Lois Orton, Helen Bromley, Francesco P Cappuccio, Simon Capewell
BACKGROUND: Non-communicable disease (NCD) prevention strategies now prioritise four major risk factors: food, tobacco, alcohol and physical activity. Dietary salt intake remains much higher than recommended, increasing blood pressure, cardiovascular disease and stomach cancer. Substantial reductions in salt intake are therefore urgently needed. However, the debate continues about the most effective approaches. To inform future prevention programmes, we systematically reviewed the evidence on the effectiveness of possible salt reduction interventions...
2017: PloS One
https://www.readbyqxmd.com/read/28533569/the-influence-of-concrete-support-on-child-welfare-program-engagement-progress-and-recurrence
#8
Whitney L Rostad, Tia McGill Rogers, Mark J Chaffin
Families living in poverty are significantly more likely to become involved with child welfare services, and consequently, referred to interventions that target abusive and neglectful parenting practices. Program engagement and retention are difficult to achieve, possibly because of the concrete resource insufficiencies that may have contributed to a family's involvement with services in the first place. Various strategies have been used to enhance program completion, such as motivational interventions, monetary incentives, and financial assistance with concrete needs...
January 2017: Children and Youth Services Review
https://www.readbyqxmd.com/read/28525607/rna-moip-prediction-of-rna-secondary-structure-and-local-3d-motifs-from-sequence-data
#9
Jason Yao, Vladimir Reinharz, François Major, Jérôme Waldisphül
RNA structures are hierarchically organized. The secondary structure is articulated around sophisticated local three-dimensional (3D) motifs shaping the full 3D architecture of the molecule. Recent contributions have identified and organized recurrent local 3D motifs, but applications of this knowledge for predictive purposes is still in its infancy. We recently developed a computational framework, named RNA-MoIP, to reconcile RNA secondary structure and local 3D motif information available in databases. In this paper, we introduce a web service using our software for predicting RNA hybrid 2D-3D structures from sequence data only...
May 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28502044/hippocampal-proteomic-analysis-reveals-distinct-pathway-deregulation-profiles-at-early-and-late-stages-in-a-rat-model-of-alzheimer-s-like-amyloid-pathology
#10
Sonia Do Carmo, Gogce Crynen, Tiffany Paradis, Jon Reed, M Florencia Iulita, Adriana Ducatenzeiler, Fiona Crawford, A Claudio Cuello
The cerebral accumulation and cytotoxicity of amyloid beta (Aβ) is central to Alzheimer's pathogenesis. However, little is known about how the amyloid pathology affects the global expression of brain proteins at different disease stages. In order to identify genotype and time-dependent significant changes in protein expression, we employed quantitative proteomics analysis of hippocampal tissue from the McGill-R-Thy1-APP rat model of Alzheimer-like amyloid pathology. McGill transgenic rats were compared to wild-type rats at early and late pathology stages, i...
May 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28485103/evaluating-a-novel-resident-role-modelling-programme
#11
Robert Sternszus, Yvonne Steinert, Farhan Bhanji, Sero Andonian, Linda S Snell
BACKGROUND: Role modelling is a fundamental method by which students learn from residents. To our knowledge, however, resident-as-teacher curricula have not explicitly addressed resident role modelling. The purpose of this project was to design, implement and evaluate an innovative programme to teach residents about role modelling. METHODS: The authors designed a resident role-modelling programme and incorporated it into the 2015 and 2016 McGill University resident-as-teacher curriculum...
May 9, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/28480639/pyrimethamine-significantly-lowers-cerebrospinal-fluid-cu-zn-superoxide-dismutase-in-amyotrophic-lateral-sclerosis-patients-with-sod1-mutations
#12
MULTICENTER STUDY
Dale J Lange, Mona Shahbazi, Vincenzo Silani, Albert C Ludolph, Jochen H Weishaupt, Senda Ajroud-Driss, Kara G Fields, Rahul Remanan, Stanley H Appel, Claudia Morelli, Alberto Doretti, Luca Maderna, Stefano Messina, Ulrike Weiland, Stefan L Marklund, Peter M Andersen
OBJECTIVE: Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1-transgenic animal models. Pyrimethamine produces dose-dependent SOD1 reduction in cell culture systems. A previous phase 1 trial showed pyrimethamine lowers SOD1 levels in leukocytes in patients with SOD1 mutations. This study investigated whether pyrimethamine lowered SOD1 levels in the cerebrospinal fluid (CSF) in patients carrying SOD1 mutations linked to familial amyotrophic lateral sclerosis (fALS/SOD1)...
June 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28479159/proteomic-analysis-of-filaggrin-deficiency-identifies-molecular-signatures-characteristic-of-atopic-eczema
#13
Martina S Elias, Heather A Long, Carla F Newman, Paul A Wilson, Andrew West, Paul J McGill, Keith C Wu, Michael J Donaldson, Nick J Reynolds
BACKGROUND: Atopic eczema (AE) is characterized by skin barrier and immune dysfunction. Null mutations in filaggrin (FLG), a key epidermal barrier protein, strongly predispose to AE; however, the precise role of FLG deficiency in AE pathogenesis remains incompletely understood. OBJECTIVES: We sought to identify global proteomic changes downstream of FLG deficiency in human epidermal living skin-equivalent (LSE) models and validate findings in skin of patients with AE...
April 28, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28444736/selective-progesterone-receptor-modulators-sprms-for-uterine-fibroids
#14
REVIEW
Ally Murji, Lucy Whitaker, Tiffany L Chow, Mara L Sobel
BACKGROUND: Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible...
April 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28444172/risk-of-venous-thromboembolism-in-patients-with-psoriatic-arthritis-psoriasis-and-rheumatoid-arthritis-a-general-population-based-cohort-study
#15
Alexis Ogdie, Neilia Kay McGill, Daniel B Shin, Junko Takeshita, Thorvardur Jon Love, Megan H Noe, Zelma C Chiesa Fuxench, Hyon K Choi, Nehal N Mehta, Joel M Gelfand
Aims: To determine the risk of venous thromboembolism (VTE) defined as the combined endpoint of deep venous thrombosis (DVT) and pulmonary embolism (PE) among patients with psoriatic arthritis (PsA), psoriasis and rheumatoid arthritis (RA) compared with population controls. Methods and results: A cohort study was conducted in a primary care medical record database in the UK with data from 1994-2014 among patients with PsA, RA, or psoriasis. Cox proportional hazards models were used to calculate the relative hazards for DVT, PE, and VTE...
April 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28400087/minimally-invasive-hepatopancreatobiliary-surgery-in-north-america-an-acs-nsqip-analysis-of-predictors-of-conversion-for-laparoscopic-and-robotic-pancreatectomy-and-hepatectomy
#16
Amer H Zureikat, Jeffrey Borrebach, Henry A Pitt, Douglas Mcgill, Melissa E Hogg, Vanessa Thompson, David J Bentrem, Bruce L Hall, Herbert J Zeh
BACKGROUND: Procedural conversion rates represent an important aspect of the feasibility of minimally invasive surgical (MIS) approaches. This study aimed to outline the rates and predictors of procedural completion/conversion for MIS hepatectomy and pancreatectomy. METHODS: All 2014 ACS-NSQIP laparoscopic and robotic hepatectomy and pancreatectomy procedures were identified and grouped into pure, open assist, or unplanned conversion to open. Risk adjusted multinomial logistic regression models were generated with completion (Pure) set as the primary outcome...
April 8, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28379089/describing-medical-student-curiosity-across-a-four-year-curriculum-an-exploratory-study
#17
Robert Sternszus, Alenoush Saroyan, Yvonne Steinert
BACKGROUND: Intellectual curiosity can be defined as a desire for knowledge that leads to exploratory behavior and consists of an inherent and stable trait (i.e. trait curiosity) and a variable context-dependent state (i.e. state curiosity). Although intellectual curiosity has been considered an important aspect of medical education and practice, its relationship to medical education has not been empirically investigated. The purpose of this exploratory study was to describe medical students' intellectual curiosity across a four-year undergraduate program...
April 2017: Medical Teacher
https://www.readbyqxmd.com/read/28365848/attenuation-of-cortical-activity-triggering-descending-pain-inhibition-in-chronic-low-back-pain-patients-a-functional-magnetic-resonance-imaging-study
#18
Yohei Matsuo, Jiro Kurata, Miho Sekiguchi, Katsuhiro Yoshida, Takuya Nikaido, Shin-Ichi Konno
PURPOSE: A considerable portion of chronic low back pain (cLBP) patients lack anatomical abnormality, resist conventional therapeutic interventions, and their symptoms are often complicated with psychological and social factors. Such patients have been reported to show cerebral abnormalities both in anatomy and function by neuroimaging studies. Here we examined differences in cerebral reactivity to a simulated low back pain stimulus between cLBP patients and healthy controls by functional magnetic resonance imaging (fMRI), and their behavioral correlates from a psychophysical questionnaire...
August 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28359431/the-effectiveness-of-psychoeducational-interventions-in-reducing-the-care-burden-of-family-members-caring-for-the-elderly-in-turkey-a-randomized-controlled-study
#19
Nur Elçin Boyacıoğlu, Yasemin Kutlu
OBJECTIVE: To examine the effectiveness of psychoeducational intervention that is based on the McGill Model of Nursing in reducing the burden of caregivers and improving self-efficacy and adaptive coping in people who provide care for the older person. METHODS: This study was conducted using a pre- and post-test control group and repeated measures experimental design in a family health center service area located in Istanbul. This study was conducted with 33 caregivers in each group...
April 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28301498/knowledge-attitudes-and-practices-kap-relating-to-brucellosis-in-smallholder-dairy-farmers-in-two-provinces-in-pakistan
#20
Shumaila Arif, Peter C Thomson, Marta Hernandez-Jover, David M McGill, Hassan Mahmood Warriach, Jane Heller
The present study aimed to assess the extent of knowledge and understanding of brucellosis in smallholder dairy farmers and identify practices at the farm and household level that might pose a risk for humans contracting brucellosis. Between February and June 2015 a cross-sectional study was conducted among smallholder farms (n = 420) in five districts of Punjab and two districts of Sindh province. Farmers were interviewed using a questionnaire to obtain information on farmers' knowledge about brucellosis and the potential risks for contracting the disease that are present for dairy farmers and their families...
2017: PloS One
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