keyword
MENU ▼
Read by QxMD icon Read
search

McGill model

keyword
https://www.readbyqxmd.com/read/29784698/aspects-of-multicomponent-integrated-care-promote-sustained-improvement-in-surrogate-clinical-outcomes-a-systematic-review-and-meta-analysis
#1
REVIEW
Lee Ling Lim, Eric S H Lau, Alice P S Kong, Melanie J Davies, Naomi S Levitt, Björn Eliasson, Carlos A Aguilar-Salinas, Guang Ning, Yutaka Seino, Wing Yee So, Margaret McGill, Graham D Ogle, Trevor J Orchard, Philip Clarke, Rury R Holman, Edward W Gregg, Juan José Gagliardino, Juliana C N Chan
OBJECTIVE: The implementation of the Chronic Care Model (CCM) improves health care quality. We examined the sustained effectiveness of multicomponent integrated care in type 2 diabetes. RESEARCH DESIGN AND METHODS: We searched PubMed and Ovid MEDLINE (January 2000-August 2016) and identified randomized controlled trials comprising two or more quality improvement strategies from two or more domains (health system, health care providers, or patients) lasting ≥12 months with one or more clinical outcomes...
June 2018: Diabetes Care
https://www.readbyqxmd.com/read/29721998/cell-transplantation-for-retinal-degeneration-transition-from-rodent-to-nonhuman-primate-models
#2
Trevor J McGill, David J Wilson, Jonathan Stoddard, Lauren M Renner, Martha Neuringer
Transplantation of potentially therapeutic cells into the subretinal space is a promising prospective therapy for the treatment of retinal degenerative diseases including age-related macular degeneration (AMD). In rodent models with photoreceptor degeneration, subretinal transplantation of cell suspensions has repeatedly been demonstrated to rescue behaviorally measured vision, maintain electrophysiological responses from the retina and the brain, and slow the degeneration of rod and cone photoreceptors for extended periods...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29607443/therapeutic-effect-of-blueberry-extracts-for-acute-myeloid-leukemia
#3
Colin M McGill, Timothy J Brown, Yuan-Yin Cheng, Lindsey N Fisher, Sriram S Shanmugavelandy, Sally J Gustafson, Kriya L Dunlap, Mary Ann Lila, Mark Kester, Paul T Toran, David F Claxton, Brian M Barth
Acute myeloid leukemia (AML) is an aggressive hematological malignancy with high incidence in the aging population. In addition, AML is one of the more common pediatric malignancies. Unfortunately, both of these patient groups are quite sensitive to chemotherapy toxicities. Investigation of blueberries specifically as an anti-AML agent has been limited, despite being a prominent natural product with no reported toxicity. In this study, blueberry extracts are reported for the first time to exert a dietary therapeutic effect in animal models of AML...
January 2018: International Journal of Biopharmaceutical Sciences
https://www.readbyqxmd.com/read/29582397/chronic-hippocampal-expression-of-notch-intracellular-domain-induces-vascular-thickening-reduces-glucose-availability-and-exacerbates-spatial-memory-deficits-in-a-rat-model-of-early-alzheimer
#4
Pablo Galeano, María C Leal, Carina C Ferrari, María C Dalmasso, Pamela V Martino Adami, María I Farías, Juan C Casabona, Mariana Puntel, Sonia Do Carmo, Clara Smal, Martín Arán, Eduardo M Castaño, Fernando J Pitossi, A Claudio Cuello, Laura Morelli
The specific roles of Notch in progressive adulthood neurodegenerative disorders have begun to be unraveled in recent years. A number of independent studies have shown significant increases of Notch expression in brains from patients at later stages of sporadic Alzheimer's disease (AD). However, the impact of Notch canonical signaling activation in the pathophysiology of AD is still elusive. To further investigate this issue, 2-month-old wild-type (WT) and hemizygous McGill-R-Thy1-APP rats (Tg(+/-)) were injected in CA1 with lentiviral particles (LVP) expressing the transcriptionally active fragment of Notch, known as Notch Intracellular Domain (NICD), (LVP-NICD), or control lentivirus particles (LVP-C)...
March 26, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29536595/directional-preference-and-functional-outcomes-among-subjects-classified-at-high-psychosocial-risk-using-start
#5
Mark W Werneke, Susan Edmond, Michelle Young, David Grigsby, Brian McClenahan, Troy McGill
BACKGROUND AND PURPOSE: Physiotherapy has an important role in managing patients with non-specific low back pain who experience elevated psychosocial distress or risk for chronic disability. In terms of evidence-based physiotherapy practice, cognitive-behavioural approaches for patients at high psychosocial risk are the recommended management to improve patient treatment outcomes. Evidence also suggests that directional preference (DP) is an important treatment effect modifier for prescribing specific exercises for patients to improve outcomes...
March 14, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/29445124/efficacy-of-mucosal-polyanhydride-nanovaccine-against-respiratory-syncytial-virus-infection-in-the-neonatal-calf
#6
Jodi L McGill, Sean M Kelly, Pankaj Kumar, Savannah Speckhart, Shannon L Haughney, Jamie Henningson, Balaji Narasimhan, Randy E Sacco
Human respiratory syncytial virus (HRSV) is a leading cause of severe acute lower respiratory tract infection in infants and children worldwide. Bovine RSV (BRSV) is closely related to HRSV and a significant cause of morbidity in young cattle. BRSV infection in calves displays many similarities to RSV infection in humans, including similar age dependency and disease pathogenesis. Polyanhydride nanoparticle-based vaccines (i.e., nanovaccines) have shown promise as adjuvants and vaccine delivery vehicles due to their ability to promote enhanced immunogenicity through the route of administration, provide sustained antigen exposure, and induce both antibody- and cell-mediated immunity...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29402701/effect-of-early-and-systematic-integration-of-palliative-care-in-patients-with-advanced-cancer-a-randomised-controlled-trial
#7
Gaëlle Vanbutsele, Koen Pardon, Simon Van Belle, Veerle Surmont, Martine De Laat, Roos Colman, Kim Eecloo, Veronique Cocquyt, Karen Geboes, Luc Deliens
BACKGROUND: The benefit of early integration of palliative care into oncological care is suggested to be due to increased psychosocial support. In Belgium, psychosocial care is part of standard oncological care. The aim of this randomised controlled trial is to examine whether early and systematic integration of palliative care alongside standard psychosocial oncological care provides added benefit compared with usual care. METHODS: In this randomised controlled trial, eligible patients were 18 years or older, and had advanced cancer due to a solid tumour, an European Cooperative Oncology Group performance status of 0-2, an estimated life expectancy of 12 months, and were within the first 12 weeks of a new primary tumour or had a diagnosis of progression...
March 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29355953/investigation-into-the-microstructure-texture-and-rheological-properties-of-chocolate-ganache
#8
Jade McGill, Rich W Hartel
Ganache is a mixture of chocolate and dairy. Although a popular confection, little is known about how it functions as a system. Objectives were to (1) determine if dairy fats and cocoa butter mix in ganache, (2) characterize ganache microstructure, and how structure affects texture and rheology, and (3) identify how changes in chocolate composition alter ganache. Textural analysis, differential scanning calorimetry, stress sweep tests, and microscopy were used to examine ganache formulations that varied in dairy source (cream or butter) or in solid fat content (SFC), composition or type of chocolate...
March 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29335347/smoking-is-the-most-significant-modifiable-lung-cancer-risk-factor-in-systemic-lupus-erythematosus
#9
Sasha Bernatsky, Rosalind Ramsey-Goldman, Michelle Petri, Murray B Urowitz, Dafna D Gladman, Paul R Fortin, Edward H Yelin, Ellen Ginzler, John G Hanly, Christine Peschken, Caroline Gordon, Ola Nived, Cynthia Aranow, Sang-Cheol Bae, David Isenberg, Anisur Rahman, James E Hansen, Yvan St Pierre, Ann E Clarke
OBJECTIVE: To assess lung cancer risk in systemic lupus erythematosus (SLE), relative to demographics, drug exposures, smoking, and disease activity. METHODS: We analyzed data from 14 SLE cohorts. We calculated adjusted HR estimates for lung cancer in SLE, relative to demographics, smoking, time-dependent medication exposures, and cumulative disease activity [mean adjusted SLE Disease Activity Index (SLEDAI) scores]. This project was approved by the ethics boards of all participating institutions, including the Institutional Review Board of the McGill University Health Centre...
March 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29291374/af710b-an-m1-sigma-1-receptor-agonist-with-long-lasting-disease-modifying-properties-in-a-transgenic-rat-model-of-alzheimer-s-disease
#10
Hélène Hall, Maria Florencia Iulita, Palma Gubert, Lisi Flores Aguilar, Adriana Ducatenzeiler, Abraham Fisher, Augusto Claudio Cuello
INTRODUCTION: AF710B (aka ANAVEX 3-71) is a novel selective allosteric M1 muscarinic and sigma-1 receptor agonist. In 3×Tg-AD mice, AF710B attenuates cognitive deficits and decreases Alzheimer-like hallmarks. We now report on the long-lasting disease-modifying properties of AF710B in McGill-R-Thy1-APP transgenic (Tg) rats. METHODS: Chronic treatment with AF710B (10 μg/kg) was initiated in postplaque 13-month-old Tg rats. Drug or vehicle was administered orally daily for 4...
December 29, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29290297/evaluation-of-three-serological-tests-for-diagnosis-of-bovine-brucellosis-in-smallholder-farms-in-pakistan-by-estimating-sensitivity-and-specificity-using-bayesian-latent-class-analysis
#11
Shumaila Arif, Jane Heller, Marta Hernandez-Jover, David M McGill, Peter C Thomson
The present study aimed to estimate the herd-level sensitivity (Se) and specificity (Sp) of three commonly used serological tests in naturally-infected cattle and buffalo in smallholder farms in Pakistan. Between February and June 2015, a cross-sectional study was carried out in five districts of Punjab (Kasur, Okara, Pakpattan, Jhelum, and Bhakkar) and two districts of Sindh (Badin and Thatta). Serum samples from mixed farms of cattle (n=441) and buffalo (n=621) were collected and tested using the Rose Bengal test (RBT), indirect ELISA (I-ELISA) and competitive ELISA (C-ELISA)...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29282415/comparison-of-the-effects-of-dry-cupping-and-acupressure-at-acupuncture-point-bl23-on-the-women-with-postpartum-low-back-pain-plbp-based-on-short-form-mcgill-pain-questionnaires-in-iran-a-randomized-controlled-trial
#12
Zahra Yazdanpanahi, Mehrnoush Ghaemmaghami, Marzieh Akbarzadeh, Najaf Zare, Amir Azisi
Objective: To evaluate the effects of acupuncture branches on postpartum low back pain severity among the primiparous subjects visiting the selected educational centers affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Materials and methods: This clinical trial was conducted on 150 (each group of 50 people) cases in 2012. Cupping therapy was done every other day in four 15-20 minute sessions a week. Besides, acupressure was applied according to the circular model for 20 minutes. The patients filled out the short form McGill Pain Questionnaires...
June 2017: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/29229212/acid-induced-experimental-muscle-pain-and-hyperalgesia-with-single-and-repeated-infusion-in-human-forearm
#13
Kelun Wang, Yi Luo, Toshiyuki Asaki, Thomas Graven-Nielsen, Brian E Cairns, Thomas Arendt-Nielsen, Lars Arendt-Nielsen
BACKGROUND AND PURPOSE: Acid has long been thought to play an important role in the pain process. Animal study showed that repeated acid stimulation induced central sensitization. The purpose of the study is to investigate muscle pain and hyperalgesia evoked by intramuscular infusion of saline at different pH levels, and to compare the effect of a single versus repeated acid infusions. METHODS: Twenty healthy subjects received infusions of buffered saline (pH 5...
October 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29202882/age-and-seasons-influence-on-at-home-pulse-oximetry-results-in-children-evaluated-for-suspected-obstructive-sleep-apnea
#14
Martino Pavone, Elisabetta Verrillo, Nicola Ullmann, Serena Caggiano, Valentina Negro, Renato Cutrera
BACKGROUND: Seasonal variability on obstructive sleep apnea has already been studied by polysomnography in children. Winter and spring season emerged as critical periods. No data are currently available for pulse oximetry performed at home. The aim of our study was to evaluate the effect of seasonality and age on the results of at-home pulse oximetry performed in children referred for suspected OSA. METHODS: We retrospectively studied 781 children (64.3% Males), aged 4...
December 4, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29134435/plant-phenology-supports-the-multi-emergence-hypothesis-for-ebola-spillover-events
#15
Katharina C Wollenberg Valero, Raphael D Isokpehi, Noah E Douglas, Seenith Sivasundaram, Brianna Johnson, Kiara Wootson, Ayana McGill
Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored. Filoviridae viruses have a wide range of natural hosts and are unstable once outside hosts. Spillover events, which involve the physical transfer of viral particles across species, could therefore be directly promoted by conditions of host ecology and environment. In this report, we outline a proof of concept that temporal fluctuations of a set of ecological and environmental variables describing the dynamics of the host ecosystem are able to predict such events of Ebola virus spillover to humans and animals...
November 13, 2017: EcoHealth
https://www.readbyqxmd.com/read/29097597/multimodal-imaging-in-rat-model-recapitulates-alzheimer-s-disease-biomarkers-abnormalities
#16
Maxime J Parent, Eduardo R Zimmer, Monica Shin, Min Su Kang, Vladimir S Fonov, Axel Mathieu, Antonio Aliaga, Alexey Kostikov, Sonia Do Carmo, Doris Dea, Judes Poirier, Jean-Paul Soucy, Serge Gauthier, A Claudio Cuello, Pedro Rosa-Neto
Imaging biomarkers are frequently proposed as endpoints for clinical trials targeting brain amyloidosis in Alzheimer's Disease (AD); however, the specific impact of amyloid-β (Aβ) aggregation on biomarker abnormalities remains elusive in AD. Using the McGill-R-Thy1-APP transgenic rat as a model of selective Aβ pathology, we characterized the longitudinal progression of abnormalities in biomarkers commonly used in AD research. Middle-aged (9-11 months) transgenic animals (both male and female) displayed mild spatial memory impairments and disrupted cingulate network connectivity measured by resting-state fMRI, even in the absence of hypometabolism (measured with PET [(18)F]FDG) or detectable fibrillary amyloidosis (measured with PET [(18)F]NAV4694)...
November 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28919509/molecular-and-macro-scale-analysis-of-enzyme-crosslinked-silk-hydrogels-for-rational-biomaterial-design
#17
Meghan McGill, Jeannine M Coburn, Benjamin P Partlow, Xuan Mu, David L Kaplan
Silk fibroin-based hydrogels have exciting applications in tissue engineering and therapeutic molecule delivery; however, their utility is dependent on their diffusive properties. The present study describes a molecular and macro-scale investigation of enzymatically-crosslinked silk fibroin hydrogels, and demonstrates that these systems have tunable crosslink density and diffusivity. We developed a liquid chromatography tandem mass spectroscopy (LC-MS/MS) method to assess the quantity and order of covalent tyrosine crosslinks in the hydrogels...
November 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28877953/anti-inflammatory-roles-of-p38%C3%AE-mapk-in-macrophages-are-context-dependent-and-require-il-10
#18
Abbas Raza, Jessica W Crothers, Mahalia M McGill, Gary M Mawe, Cory Teuscher, Dimitry N Krementsov
The p38 MAPK pathway was originally identified as a master regulator of proinflammatory cytokine production by myeloid cells. Numerous drugs targeting this kinase showed promise in preclinical models of inflammatory disease, but so far, none have shown efficacy in clinical trials. The reasons behind this are unclear, but may, in part, be explained by emerging anti-inflammatory functions of this kinase or overly refined selectivity of second-generation pharmacologic inhibitors. Here, we show that p38α signaling in macrophages plays pro- and anti-inflammatory functions in vivo and in vitro, with the outcome depending on the stimulus, output, kinetics, or mode of kinase inhibition (genetic vs...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28865749/differential-deregulation-of-ngf-and-bdnf-neurotrophins-in-a-transgenic-rat-model-of-alzheimer-s-disease
#19
M Florencia Iulita, M Beatriz Bistué Millón, Rowan Pentz, Lisi Flores Aguilar, Sonia Do Carmo, Simon Allard, Bernadeta Michalski, Edward N Wilson, Adriana Ducatenzeiler, Martin A Bruno, Margaret Fahnestock, A Claudio Cuello
Evidence from human neuropathological studies indicates that the levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are compromised in Alzheimer's disease. However, the causes and temporal (pathology-dependent) evolution of these alterations are not completely understood. To elucidate these issues, we investigated the McGill-R-Thy1-APP transgenic rat, which exhibits progressive intracellular and extracellular amyloid-beta (Aβ) pathology and ensuing cognitive deficits...
December 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28816143/radiation-therapy-versus-no-radiation-therapy-to-the-neo-breast-following-skin-sparing-mastectomy-and-immediate-autologous-free-flap-reconstruction-for-breast-cancer-patient-reported-and-surgical-outcomes-at-1-year-a-mastectomy-reconstruction-outcomes-consortium
#20
MULTICENTER STUDY
Andrew L Cooke, Julian Diaz-Abele, Tom Hayakawa, Ed Buchel, Kimberly Dalke, Pascal Lambert
PURPOSE: To determine whether adjuvant radiation therapy (RT) is associated with adverse patient-reported outcomes and surgical complications 1 year after skin-sparing mastectomy and immediate autologous free flap reconstruction for breast cancer. METHODS AND MATERIALS: We compared 24 domains of patient-reported outcome measures 1 year after autologous reconstruction between patients who received adjuvant RT and those who did not. A total of 125 patients who underwent surgery between 2012 and 2015 at our institution were included from the Mastectomy Reconstruction Outcomes Consortium study database...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
keyword
keyword
80903
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"