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https://www.readbyqxmd.com/read/29335347/smoking-is-the-most-significant-modifiable-lung-cancer-risk-factor-in-systemic-lupus-erythematosus
#1
Sasha Bernatsky, Rosalind Ramsey-Goldman, Michelle Petri, Murray B Urowitz, Dafna D Gladman, Paul R Fortin, Edward H Yelin, Ellen Ginzler, John G Hanly, Christine Peschken, Caroline Gordon, Ola Nived, Cynthia Aranow, Sang-Cheol Bae, David Isenberg, Anisur Rahman, James E Hansen, Yvan St Pierre, Ann E Clarke
OBJECTIVE: To assess lung cancer risk in systemic lupus erythematosus (SLE), relative to demographics, drug exposures, smoking, and disease activity. METHODS: We analyzed data from 14 SLE cohorts. We calculated adjusted HR estimates for lung cancer in SLE, relative to demographics, smoking, time-dependent medication exposures, and cumulative disease activity [mean adjusted SLE Disease Activity Index (SLEDAI) scores]. This project was approved by the ethics boards of all participating institutions, including the Institutional Review Board of the McGill University Health Centre...
January 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29291374/af710b-an-m1-sigma-1-receptor-agonist-with-long-lasting-disease-modifying-properties-in-a-transgenic-rat-model-of-alzheimer-s-disease
#2
Hélène Hall, M Florencia Iulita, Palma Gubert, Lisi Flores Aguilar, Adriana Ducatenzeiler, Abraham Fisher, A Claudio Cuello
INTRODUCTION: AF710B (aka ANAVEX 3-71) is a novel selective allosteric M1 muscarinic and sigma-1 receptor agonist. In 3×Tg-AD mice, AF710B attenuates cognitive deficits and decreases Alzheimer-like hallmarks. We now report on the long-lasting disease-modifying properties of AF710B in McGill-R-Thy1-APP transgenic (Tg) rats. METHODS: Chronic treatment with AF710B (10 μg/kg) was initiated in postplaque 13-month-old Tg rats. Drug or vehicle was administered orally daily for 4...
December 29, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29290297/evaluation-of-three-serological-tests-for-diagnosis-of-bovine-brucellosis-in-smallholder-farms-in-pakistan-by-estimating-sensitivity-and-specificity-using-bayesian-latent-class-analysis
#3
Shumaila Arif, Jane Heller, Marta Hernandez-Jover, David M McGill, Peter C Thomson
The present study aimed to estimate the herd-level sensitivity (Se) and specificity (Sp) of three commonly used serological tests in naturally-infected cattle and buffalo in smallholder farms in Pakistan. Between February and June 2015, a cross-sectional study was carried out in five districts of Punjab (Kasur, Okara, Pakpattan, Jhelum, and Bhakkar) and two districts of Sindh (Badin and Thatta). Serum samples from mixed farms of cattle (n=441) and buffalo (n=621) were collected and tested using the Rose Bengal test (RBT), indirect ELISA (I-ELISA) and competitive ELISA (C-ELISA)...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29282415/comparison-of-the-effects-of-dry-cupping-and-acupressure-at-acupuncture-point-bl23-on-the-women-with-postpartum-low-back-pain-plbp-based-on-short-form-mcgill-pain-questionnaires-in-iran-a-randomized-controlled-trial
#4
Zahra Yazdanpanahi, Mehrnoush Ghaemmaghami, Marzieh Akbarzadeh, Najaf Zare, Amir Azisi
Objective: To evaluate the effects of acupuncture branches on postpartum low back pain severity among the primiparous subjects visiting the selected educational centers affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Materials and methods: This clinical trial was conducted on 150 (each group of 50 people) cases in 2012. Cupping therapy was done every other day in four 15-20 minute sessions a week. Besides, acupressure was applied according to the circular model for 20 minutes. The patients filled out the short form McGill Pain Questionnaires...
June 2017: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/29229212/acid-induced-experimental-muscle-pain-and-hyperalgesia-with-single-and-repeated-infusion-in-human-forearm
#5
Kelun Wang, Yi Luo, Toshiyuki Asaki, Thomas Graven-Nielsen, Brian E Cairns, Thomas Arendt-Nielsen, Lars Arendt-Nielsen
BACKGROUND AND PURPOSE: Acid has long been thought to play an important role in the pain process. Animal study showed that repeated acid stimulation induced central sensitization. The purpose of the study is to investigate muscle pain and hyperalgesia evoked by intramuscular infusion of saline at different pH levels, and to compare the effect of a single versus repeated acid infusions. METHODS: Twenty healthy subjects received infusions of buffered saline (pH 5...
October 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29202882/age-and-seasons-influence-on-at-home-pulse-oximetry-results-in-children-evaluated-for-suspected-obstructive-sleep-apnea
#6
Martino Pavone, Elisabetta Verrillo, Nicola Ullmann, Serena Caggiano, Valentina Negro, Renato Cutrera
BACKGROUND: Seasonal variability on obstructive sleep apnea has already been studied by polysomnography in children. Winter and spring season emerged as critical periods. No data are currently available for pulse oximetry performed at home. The aim of our study was to evaluate the effect of seasonality and age on the results of at-home pulse oximetry performed in children referred for suspected OSA. METHODS: We retrospectively studied 781 children (64.3% Males), aged 4...
December 4, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29134435/plant-phenology-supports-the-multi-emergence-hypothesis-for-ebola-spillover-events
#7
Katharina C Wollenberg Valero, Raphael D Isokpehi, Noah E Douglas, Seenith Sivasundaram, Brianna Johnson, Kiara Wootson, Ayana McGill
Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored. Filoviridae viruses have a wide range of natural hosts and are unstable once outside hosts. Spillover events, which involve the physical transfer of viral particles across species, could therefore be directly promoted by conditions of host ecology and environment. In this report, we outline a proof of concept that temporal fluctuations of a set of ecological and environmental variables describing the dynamics of the host ecosystem are able to predict such events of Ebola virus spillover to humans and animals...
November 13, 2017: EcoHealth
https://www.readbyqxmd.com/read/29097597/multimodal-imaging-in-rat-model-recapitulates-alzheimer-s-disease-biomarkers-abnormalities
#8
Maxime J Parent, Eduardo R Zimmer, Monica Shin, Min Su Kang, Vladimir S Fonov, Axel Mathieu, Antonio Aliaga, Alexey Kostikov, Sonia Do Carmo, Doris Dea, Judes Poirier, Jean-Paul Soucy, Serge Gauthier, A Claudio Cuello, Pedro Rosa-Neto
Imaging biomarkers are frequently proposed as endpoints for clinical trials targeting brain amyloidosis in Alzheimer's Disease (AD); however, the specific impact of amyloid-β (Aβ) aggregation on biomarker abnormalities remains elusive in AD. Using the McGill-R-Thy1-APP transgenic rat as a model of selective Aβ pathology, we characterized the longitudinal progression of abnormalities in biomarkers commonly used in AD research. Middle-aged (9-11 months) transgenic animals (both male and female) displayed mild spatial memory impairments and disrupted cingulate network connectivity measured by resting-state fMRI, even in the absence of hypometabolism (measured with PET [(18)F]FDG) or detectable fibrillary amyloidosis (measured with PET [(18)F]NAV4694)...
November 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28919509/molecular-and-macro-scale-analysis-of-enzyme-crosslinked-silk-hydrogels-for-rational-biomaterial-design
#9
Meghan McGill, Jeannine M Coburn, Benjamin P Partlow, Xuan Mu, David L Kaplan
Silk fibroin-based hydrogels have exciting applications in tissue engineering and therapeutic molecule delivery; however, their utility is dependent on their diffusive properties. The present study describes a molecular and macro-scale investigation of enzymatically-crosslinked silk fibroin hydrogels, and demonstrates that these systems have tunable crosslink density and diffusivity. We developed a liquid chromatography tandem mass spectroscopy (LC-MS/MS) method to assess the quantity and order of covalent tyrosine crosslinks in the hydrogels...
November 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28877953/anti-inflammatory-roles-of-p38%C3%AE-mapk-in-macrophages-are-context-dependent-and-require-il-10
#10
Abbas Raza, Jessica W Crothers, Mahalia M McGill, Gary M Mawe, Cory Teuscher, Dimitry N Krementsov
The p38 MAPK pathway was originally identified as a master regulator of proinflammatory cytokine production by myeloid cells. Numerous drugs targeting this kinase showed promise in preclinical models of inflammatory disease, but so far, none have shown efficacy in clinical trials. The reasons behind this are unclear, but may, in part, be explained by emerging anti-inflammatory functions of this kinase or overly refined selectivity of second-generation pharmacologic inhibitors. Here, we show that p38α signaling in macrophages plays pro- and anti-inflammatory functions in vivo and in vitro, with the outcome depending on the stimulus, output, kinetics, or mode of kinase inhibition (genetic vs...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28865749/differential-deregulation-of-ngf-and-bdnf-neurotrophins-in-a-transgenic-rat-model-of-alzheimer-s-disease
#11
M Florencia Iulita, M Beatriz Bistué Millón, Rowan Pentz, Lisi Flores Aguilar, Sonia Do Carmo, Simon Allard, Bernadeta Michalski, Edward N Wilson, Adriana Ducatenzeiler, Martin A Bruno, Margaret Fahnestock, A Claudio Cuello
Evidence from human neuropathological studies indicates that the levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are compromised in Alzheimer's disease. However, the causes and temporal (pathology-dependent) evolution of these alterations are not completely understood. To elucidate these issues, we investigated the McGill-R-Thy1-APP transgenic rat, which exhibits progressive intracellular and extracellular amyloid-beta (Aβ) pathology and ensuing cognitive deficits...
September 1, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28816143/radiation-therapy-versus-no-radiation-therapy-to-the-neo-breast-following-skin-sparing-mastectomy-and-immediate-autologous-free-flap-reconstruction-for-breast-cancer-patient-reported-and-surgical-outcomes-at-1-year-a-mastectomy-reconstruction-outcomes-consortium
#12
MULTICENTER STUDY
Andrew L Cooke, Julian Diaz-Abele, Tom Hayakawa, Ed Buchel, Kimberly Dalke, Pascal Lambert
PURPOSE: To determine whether adjuvant radiation therapy (RT) is associated with adverse patient-reported outcomes and surgical complications 1 year after skin-sparing mastectomy and immediate autologous free flap reconstruction for breast cancer. METHODS AND MATERIALS: We compared 24 domains of patient-reported outcome measures 1 year after autologous reconstruction between patients who received adjuvant RT and those who did not. A total of 125 patients who underwent surgery between 2012 and 2015 at our institution were included from the Mastectomy Reconstruction Outcomes Consortium study database...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28782021/community-level-regulation-of-temporal-trends-in-biodiversity
#13
Nicholas J Gotelli, Hideyasu Shimadzu, Maria Dornelas, Brian McGill, Faye Moyes, Anne E Magurran
Many theoretical models of community dynamics predict that species richness (S) and total abundance (N) are regulated in their temporal fluctuations. We present novel evidence for widespread regulation of biodiversity. For 59 plant and animal assemblages from around the globe monitored annually for a decade or more, the majority exhibited regulated fluctuations compared to the null hypothesis of an unconstrained random walk. However, there was little evidence for statistical artifacts, regulation driven by correlations with average annual temperature, or local-scale compensatory fluctuations in S or N...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28754387/cost-of-cardiac-surgery-in-frail-compared-with-nonfrail-older-adults
#14
MULTICENTER STUDY
Michael Goldfarb, Melissa Bendayan, Lawrence G Rudski, Jean-Francois Morin, Yves Langlois, Felix Ma, Kevin Lachapelle, Renzo Cecere, Benoit DeVarennes, Christo I Tchervenkov, James M Brophy, Jonathan Afilalo
BACKGROUND: Frailty is a risk factor for mortality, morbidity, and prolonged length of stay after cardiac surgery, all of which are major drivers of hospitalization costs. The incremental hospitalization costs incurred in frail patients have yet to be elucidated. METHODS: Patients aged ≥ 60 years were evaluated for frailty before coronary artery bypass grafting or heart valve surgery at 2 academic centres between 2013 and 2015 as part of the McGill Frailty Registry...
August 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28713853/factors-associated-with-acute-postoperative-pain-following-breast-reconstruction
#15
Anita R Kulkarni, Andrea L Pusic, Jennifer B Hamill, Hyungjin M Kim, Ji Qi, Edwin G Wilkins, Randy S Roth
INTRODUCTION: Post-mastectomy breast reconstruction has become an increasingly important component of breast cancer treatment. Unfortunately, some patients experience severe postoperative pain, placing them at risk for increased clinical morbidity and the development of disabling chronic pain. In an attempt to identify at-risk patients, we prospectively evaluated patient characteristics and medical/surgical variables associated with more severe acute post-reconstruction pain. METHODS: Women (N = 2207; one-week 82...
March 2017: JPRAS Open
https://www.readbyqxmd.com/read/28709680/patient-satisfaction-with-laser-sintered-removable-partial-dentures-a-crossover-pilot-clinical-trial
#16
Balqees Almufleh, Elham Emami, Omar Alageel, Fabiana de Melo, Francois Seng, Eric Caron, Samer Abi Nader, Ashwaq Al-Hashedi, Rubens Albuquerque, Jocelyne Feine, Faleh Tamimi
STATEMENT OF PROBLEM: Clinical data regarding newly introduced laser-sintered removable partial dentures (RPDs) are needed before this technique can be recommended. Currently, only a few clinical reports have been published, with no clinical studies. PURPOSE: This clinical trial compared short-term satisfaction in patients wearing RPDs fabricated with conventional or computer-aided design and computer-aided manufacturing (CAD-CAM) laser-sintering technology. MATERIAL AND METHODS: Twelve participants with partial edentulism were enrolled in this pilot crossover double-blinded clinical trial...
July 11, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28693329/a-novel-approach-to-improving-patient-experience-in-orthopedics
#17
Spencer M Stein, Sarav S Shah, Alanna Carcich, Marlena McGill, Isaac Gammal, Michael Langino, Thomas Mauri
The patient experience domain comprises a significant portion of the Hospital Value-Based Purchasing program. This study investigated whether an intervention focusing on attending physician awareness, resident and physician assistant education, and multidisciplinary patient-centric care had an effect on patient perceived physician communication and overall hospital ratings. Responses to the Hospital Consumer Assessment of Healthcare Providers and Systems survey were reviewed in 2014 and 2015. Patients' perceptions that the physician explained their condition in ways they understood and the overall hospital rating improved significantly after implantation of the model ( P < ...
February 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28684100/automaticity-of-force-application-during-simulated-brain-tumor-resection-testing-the-fitts-and-posner-model
#18
Abdulgadir Bugdadi, Robin Sawaya, Duaa Olwi, Gmaan Al-Zhrani, Hamed Azarnoush, Abdulrahman Jafar Sabbagh, Ghusn Alsideiri, Khalid Bajunaid, Fahad E Alotaibi, Alexander Winkler-Schwartz, Rolando Del Maestro
OBJECTIVE: The Fitts and Posner model of motor learning hypothesized that with deliberate practice, learners progress through stages to an autonomous phase of motor ability. To test this model, we assessed the automaticity of neurosurgeons, senior residents, and junior residents when operating on 2 identical tumors using the NeuroVR virtual reality simulation platform. DESIGN: Participants resected 9 identical simulated tumors on 2 occasions (total = 18 resections)...
July 3, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28670914/high-prevalence-of-chronic-pain-with-neuropathic-characteristics-after-open-reduction-and-internal-fixation-of-ankle-fractures
#19
Nadia Rbia, Cornelis H van der Vlies, Berry I Cleffken, Ruud W Selles, Steven E R Hovius, Tim H J Nijhuis
BACKGROUND: Unstable ankle fractures require treatment with open reduction and internal fixation (ORIF). Long-term functional outcome is satisfying in most patients; however, a number of patients have persistent complaints. Superficial nerve complications following ankle surgery may be the cause of chronic pain and disability. METHODS: In this observational retrospective survey, a cohort of 527 women and men, who underwent ORIF in the period from January 2007 to January 2014, were invited to an online questionnaire...
September 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28643399/distributed-health-literacy-among-people-living-with-type-2-diabetes-in-portugal-defining-levels-of-awareness-and-support
#20
Liliana Abreu, João Arriscado Nunes, Peter Taylor, Susana Silva
This study embraces a patient-centred and narrative-oriented notion of health literacy, exploring how social networks and personal experiences constitute distributed health literacy (DHL) by mapping out health literacy mediators of each individual and how they enable self-management skills and knowledge of health conditions. Semi-structured interviews with 26 patients with type 2 diabetes were conducted in a Primary Care Center of Porto (Portugal) from October 2014 to December 2015. Data were collected based on McGill Illness Narrative Interview (MINI)...
June 22, 2017: Health & Social Care in the Community
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