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https://www.readbyqxmd.com/read/28110417/splenic-enlargement-and-bone-marrow-hyperplasia-in-patients-receiving-trastuzumab-emtansine-for-metastatic-breast-cancer
#1
Michael Kosmin, Andreas Makris, Noorulhuda Jawad, David Woolf, David Miles, Anwar R Padhani
BACKGROUND: An association between trastuzumab-emtansine (T-DM1) and splenic enlargement is reported in preclinical data, and has been noted anecdotally in patients receiving T-DM1 at our institution. Use of whole-body MRI examinations (WB-MRI) allows for detailed bone marrow assessment and semi-automated splenic volume calculations. OBJECTIVE: To retrospectively evaluate changes in splenic volume versus evidence of bone marrow hyperplasia and/or changes in portal venous pressure in patients receiving T-DM1 for metastatic breast cancer...
January 21, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28109977/c-fos-expression-in-the-parabrachial-nucleus-following-intraoral-bitter-stimulation-in-the-rat-with-dietary-induced-zinc-deficiency
#2
Akiyo Kawano, Shiho Honma, Chizuko Inui-Yamamoto, Akira Ito, Hitoshi Niwa, Satoshi Wakisaka
Zinc deficiency causes various symptoms including taste disorders. In the present study, changes in expression of c-Fos immunoreactivity in neurons of the parabrachial nucleus (PBN), one of the relay nuclei for transmission of gustatory information, after bitter stimulation to the dorsal surface of the tongue were examined in zinc-deficient rats. Experimental zinc-deficient animals were created by feeding a low-zinc diet for 4 weeks, and showed the following symptoms of zinc deficiency: low body weight, low serum zinc content and behavioral changes to avoid bitter stimulation...
January 18, 2017: Brain Research
https://www.readbyqxmd.com/read/28109750/phytosphingosine-sphingosine-and-dihydrosphingosine-ceramides-in-model-skin-lipid-membranes-permeability-and-biophysics
#3
Barbora Školová, Andrej Kováčik, Ondřej Tesař, Lukáš Opálka, Kateřina Vávrová
Ceramides based on phytosphingosine, sphingosine and dihydrosphingosine are essential constituents of the skin lipid barrier that protects the body from excessive water loss. The roles of the individual ceramide subclasses in regulating skin permeability and the reasons for C4-hydroxylation of these sphingolipids are not completely understood. We investigated the chain length-dependent effects of dihydroceramides, sphingosine ceramides (with C4-unsaturation) and phytoceramides (with C4-hydroxyl) on the permeability, lipid organization and thermotropic behavior of model stratum corneum lipid membranes composed of ceramide/lignoceric acid/cholesterol/cholesteryl sulfate...
January 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28109731/eating-moderates-the-link-between-body-mass-index-and-perceived-social-connection
#4
Lisa M Jaremka, Naoyuki Sunami, Megan A Nadzan
Some studies have demonstrated that heavier people perceive themselves as lacking social connections, whereas others have not. The current study investigated whether eating alters the link between body mass index (BMI) and perceived social connection, providing one explanation for inconsistencies across previous studies. Participants were instructed to refrain from eating or drinking anything except water after 9 p.m. the prior night. Upon arrival at the lab, participants were assigned to the food (n = 63) or no food (n = 110) condition...
January 18, 2017: Appetite
https://www.readbyqxmd.com/read/28109599/effect-of-intramammary-infusion-of-chitosan-hydrogels-at-drying-off-on-bovine-mammary-gland-involution
#5
S Lanctôt, P Fustier, A R Taherian, B Bisakowski, X Zhao, P Lacasse
The transition from lactation to the dry period in dairy cows is a period of high risk for acquiring new intramammary infections. This risk is reduced when the involution of the mammary gland is completed. Accordingly, approaches that speed up the involution process after drying-off could reduce the incidence of mastitis. The current study aimed to develop a biological response modifier that could be injected into cow teats to promote immune cell migration and speed up involution. Chitosan, a natural polysaccharide derived from chitin, is able to trigger host innate immunity...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28108959/innovative-root-end-filling-materials-based-on-calcium-silicates-and-calcium-phosphates
#6
Ali Abedi-Amin, Arlinda Luzi, Massimo Giovarruscio, Gaetano Paolone, Atanaz Darvizeh, Victoria Vivó Agulló, Salvatore Sauro
This in vitro study evaluated the apical sealing ability, bioactivity and biocompatibility of an experimental calcium silicate-based and two light-curing calcium silicate/calcium-phosphate cements as potential root end filling materials. A calcium silicate Portland-based (Control PC), an experimental calcium silicate (Exp. PC) and two light-curing cements (LC-CaP; LC-Si/CaP) were assessed for their alkalinising activity (pH) and biocompatibility. Single-rooted human canines were endodontically treated, filled with gutta-percha and finally submitted to apicoectomy...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28107778/parabolic-variation-in-sexual-selection-intensity-across-the-range-of-a%C3%A2-cold-water-pipefish-implications-for-susceptibility-to-climate-change
#7
Nuno Monteiro, Mário Cunha, Lídia Ferreira, Natividade Vieira, Agostinho Antunes, David Lyons, Adam G Jones
While an understanding of evolutionary processes in shifting environments is vital in the context of rapid ecological change, one of the most potent selective forces, sexual selection, remains curiously unexplored. Variation in sexual selection across a species range, especially across a gradient of temperature regimes, has the potential to provide a window into the possible impacts of climate change on the evolution of mating patterns. Here, we investigated some of the links between temperature and indicators of sexual selection, using a cold-water pipefish as model...
January 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28107465/lead-exposure-induces-weight-gain-in-adult-rats-accompanied-by-dna-hypermethylation
#8
Honglin Sun, Ningjian Wang, Xiaomin Nie, Li Zhao, Qin Li, Zhen Cang, Chi Chen, Meng Lu, Jing Cheng, Hualing Zhai, Fangzhen Xia, Lin Ye, Yingli Lu
OBJECTIVE: Previous studies have revealed the association of lead (Pb) exposure with obesity. DNA methylation alteration has been suggested to be one of the regulatory mechanisms of obesity. We aimed to explore whether Pb exposure is related with weight gain and DNA methylation alteration. METHODS: Male adult 8 week Wistar rats were divided into 5 groups: the normal chow diet (NCD); the NCD+0.05%Pb; the NCD+0.15%Pb; the NCD+0.45%Pb and the high fat diet. Rats were exposed to different dosages of Pb through drinking water for 21 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28106545/the-alterations-of-serum-fgf-21-levels-metabolic-and-body-composition-in-early-breast-cancer-patients-receiving-adjuvant-endocrine-therapy
#9
Murat Akyol, Ahmet Alacacioglu, Leyla Demir, Yuksel Kucukzeybek, Yasar Yildiz, Zehra Gumus, Mete Kara, Tarik Salman, Umut Varol, Halil Taskaynatan, Utku Oflazoglu, Vedat Bayoglu, Mustafa Oktay Tarhan
BACKGROUND: In early breast cancer patients, the effects of hormonal therapy (tamoxifen and aromatase inhibitors) on plasma fibroblast growth factor 21 (FGF-21), lipid levels and body composition have not yet been investigated. Therefore, we aimed to analyze the relationship between FGF-21 and body composition as well as the effects of tamoxifen and aromatase inhibitors on plasma lipid levels, FGF-21, and body composition. METHODS: A total of 72 patients were treated with either tamoxifen or aromatase inhibitors due to their menopausal status after adjuvant radiotherapy...
January 13, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28106140/gradient-hierarchic-aligned-porosity-sioc-ceramics
#10
Cekdar Vakifahmetoglu, Damla Zeydanli, Murilo Daniel de Mello Innocentini, Fernanda Dos Santos Ribeiro, Paulo Renato Orlandi Lasso, Gian Domenico Soraru
This work describes a simple technique to produce porous ceramics with aligned porosity having very high permeability and specific surface area. SiOC-based compositions were processed from blends of three types of preceramic polymer and a catalyst, followed by curing and pyrolysis. The heating applied from the bottom of molds promoted the nucleation, expansion and rising of gas bubbles, and the creation of a ceramic matrix with axially oriented channels interconnected by small round pores. The samples were analyzed by SEM, tomography, BET, water immersion porosimetry and permeation to gas flow...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105862/structural-data-and-immunomodulatory-properties-of-a-water-soluble-heteroglycan-extracted-from-the-mycelium-of-an-italian-isolate-of-ganoderma-lucidum
#11
Raffaele Carrieri, Rosanna Manco, Daniela Sapio, Marco Iannaccone, Andrea Fulgione, Marina Papaianni, Bruna de Falco, Laura Grauso, Paola Tarantino, Flora Ianniello, Virginia Lanzotti, Ernesto Lahoz, Rosanna Capparelli
Mushrooms produce a wide range of bioactive polysaccharides, different from each other in chemical structure and biological effects. In the last years, the idea to develop functional foods or drugs containing fungal polysaccharides is attracting great attention. Fruiting bodies of Basidiomycetes Ganoderma lucidum are commonly used in Oriental medicine to treat several disorders. G. lucidum polysaccharides - mainly β-glucans and heteroglycans - have numerous biological properties such as antitumour and immunomodulatory activities...
January 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28105342/five-percent-dextrose-maximizes-dose-delivery-of-yttrium-90-resin-microspheres-and-reduces-rates-of-premature-stasis-compared-to-sterile-water
#12
Mary Ellen Koran, Samantha Stewart, Jennifer C Baker, Andrew J Lipnik, Fil Banovac, Reed A Omary, Daniel B Brown
Resin Yttrium-90 (Y90) microspheres have historically been infused using sterile water (H2O). In 2013, recommendations expanded to allow delivery with 5% dextrose in water (D5W). In this retrospective study, we hypothesized that D5W would improve Y90 delivery with a lower incidence of stasis. We reviewed 190 resin Y90 infusions using H2O (n=137) or D5W (n=53). Y90 dosimetry was calculated using the body surface area method. Infusion was halted if intra-arterial stasis was fluoroscopically identified prior to clearing the vial...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28104983/hydrogen-sulfide-attenuates-gastric-mucosal-injury-induced-by-restraint-water-immersion-stress-via-activation-of-katp-channel-and-nf-%C3%AE%C2%BAb-dependent-pathway
#13
Hong-Zhao Sun, Shan Zheng, Kai Lu, Feng-Tian Hou, Jie-Xue Bi, Xue-Lian Liu, Shan-Shan Wang
AIM: To explore the effect of hydrogen sulfide (H2S) on restraint water-immersion stress (RWIS)-induced gastric lesions in rats and the influence of adenosine triphosphate (ATP)-sensitive potassium (KATP) channels and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway on such an effect. METHODS: Male Wistar rats were randomly divided into a control group, a physiological saline (PS) group, a sodium hydrosulfide (NaHS) group, a glibenclamide (Gl) group, Gl plus NaHS group, a pyrrolidine dithiocarbamate (PDTC) group, and a PDTC plus NaHS group...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28104370/unusual-reversible-elastomeric-gels-from-nostoc-commune
#14
Sol Rodriguez, Karen N Gonzales, Eduardo G Romero, Omar P Troncoso, Fernando G Torres
Nostoc commune cyanobacteria grow in extreme conditions of desiccation and nutrient-poor soils. Their colonies form spherical gelatinous bodies are composed of a variety of polysaccharides that allow them to store water and nutrients. In this paper, we study this type of biological gel that shows characteristics of both chemical and physical gels. The structure of this gel was assessed by means of scanning electron microscopy, plate-plate rheometry, Fourier transform infrared spectroscopy and absorption/desorption tests...
January 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28104353/fluid-energy-and-nutrient-recovery-via-ad-libitum-intake-of-different-fluids-and-food
#15
Nadia Campagnolo, Elizaveta Iudakhina, Christopher Irwin, Matthew Schubert, Gregory R Cox, Michael Leveritt, Ben Desbrow
INTRODUCTION: This study compared the effects of ad libitum consumption of different beverages and foods on fluid retention and nutrient intake following exercise. METHODS: Ten endurance trained males (mean±SD; Age=25.3±4.9years, VO2max=63.0±7.2ml·kg·min(-1)) performed four trials employing a counterbalanced, crossover design. Following 60min of exercise (matched for energy expenditure and fluid loss) participants consumed either water (W1 and W2), a sports drink (Powerade® (P)) or a milk-based liquid meal supplement (Sustagen Sport® (SS)) over a four hour recovery period...
January 16, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28104350/neonatal-exposure-to-bde-209-impaired-learning-and-memory-decreased-expression-of-hippocampal-core-snares-and-synaptophysin-in-adult-rats
#16
Xiong Li, Chunmei Wang, Wen Wang, Chengwei Yue, Yan Tang
Polybrominated diphenyl ethers (PBDEs) are a class of flame retardants. While the mechanism remains unknown, the potential neurotoxic effects of PBDEs remain a relevant issue. In the present study, neonatal Sprague-Dawley rats of both sexes were administered BDE 209 (1, 10, or 20mg/kg body weight) or peanut oil once daily from postnatal day (PND) 5 to PND 10. We examined the spatial learning and memory by Morris water maze and the working and reference memory by eight-arm radial maze in the stage of adulthood...
January 16, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28103993/-effects-of-hypertonic-sodium-saline-resuscitation-on-the-liver-damage-of-rats-at-early-stage-of-severe-scald
#17
J P Zhou, Z Gao, Y X Sun, X L Chen, X S Wu, F Wang
Objective: To explore the effects of hypertonic sodium saline (HSS) resuscitation on the liver damage of rats at early stage of severe scald. Methods: Fifty-six SD rats were divided into sham injury group (SI, n=8), lactated Ringer's solution group (LRS, n=24), and group HSS (n=24) according to the random number table. Rats in group SI were sham injured without resuscitation, while rats in the other two groups were reproduced deep partial-thickness to full-thickness scald model with 30% total body surface area on the back...
January 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28103989/-experimental-research-on-the-effects-of-different-activators-on-the-formation-of-platelet-rich-gel-and-the-release-of-bioactive-substances-in-human-platelet-rich-plasma
#18
Y Yang, W Zhang, B Cheng
Objective: To explore the effects of calcium gluconate and thrombin on the formation of platelet-rich gel (PRG) and the release of bioactive substances in human platelet-rich plasma (PRP) and the clinical significance. Methods: Six healthy blood donors who met the inclusion criteria were recruited in our unit from May to August in 2016. Platelet samples of each donor were collected for preparation of PRP. (1) PRP in the volume of 10 mL was collected from each donor and divided into thrombin activation group (TA, added with 0...
January 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28103774/formulation-development-and-evaluation-of-lyophilized-nasal-inserts-for-migraine-treatment
#19
Atishkumar Mundada, Harshada Sarode
BACKGROUND: Nasal inserts are novel, solid, bioadhesive dosage forms administered via nasal route for prolonged systemic drug delivery. The principle of the dosage form is that, after administration nasal inserts imbibe nasal fluid from the mucosa and form a gel in the nasal cavity in order to avoid foreign body sensation. The objective of this investigation was the development of chitosan/xanthan gum based bioadhesive nasal inserts of antimigraine drug. METHODS: Lyophilization is more usual technique for the preparation of nasal inserts and it is one of the applied methods for drying of solids either in the form of aqueous solution or rarely in the form of aqueous suspension by using freeze dryers...
January 18, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28103486/combined-toxic-effects-and-mechanisms-of-microsystin-lr-and-copper-on-vallisneria-natans-lour-hara-seedlings
#20
Zhi Wang, Junqian Zhang, Enhua Li, Liang Zhang, Xuelei Wang, Lirong Song
Microcystin-LR (MCLR) and copper are commonly found in eutrophic water bodies because of eutrophic run-offs, cyanobacterial blooms, and copper algicide applications. However, the ecotoxicological risk of their combination remains unknown. This study investigated the effect of MCLR, Cu, and their mixture on the growth and physiological responses of Vallisneria natans. Results showed that the combined toxicity of them was concentration dependent. Synergistic effects were elicited at low concentrations of MCLR and Cu exposure (≤0...
January 3, 2017: Journal of Hazardous Materials
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