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Allergy protein from cow's milk

T Banti, A Carsin, B Chabrol, R Reynaud, A Fabre
: Infant food diversification has undergone a rapid succession of good practice recommendations in France, but there has been no assessment of pediatrician practices on food diversification. OBJECTIVE: To assess the practices of pediatricians in relation to current recommendations of the French Society of Pediatrics on infant food diversification. METHODS: This was an observational study conducted from 1 November 2014 to 31 March 2015. The study population consisted of 97 pediatricians in the Var department and 84 pediatric residents assigned to the University of Aix-Marseille in France...
October 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Aaron J O'Sullivan, Sandrine Pigat, Cian O'Mahony, Michael J Gibney, Aideen I McKevitt
The choice of suitable normal foods is limited for individuals with particular medical conditions e.g. inborn errors of metabolism (phenylketonuria, PKU) or severe cow's milk protein allergy (CMPA). Patients may have dietary restrictions and exclusive or partial replacement of specific food groups with specially formulated products to meet particular nutrition requirements. Artificial sweeteners are used to improve the appearance and palatability of such food products to avoid food refusal and ensure dietary adherence...
September 9, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Cong Yanjun, Zhou Shengyun, Li Linfeng
α-Lactalbumin represents one of the major allergens causing cow milk allergy. Few studies have clearly evaluated immunological relationships between immunoglobulin E (IgE) and immunoglobulin G (IgG)-binding epitopes of α-lactalbumin. IgE- and IgG-binding epitopes were immunolabeled with individual sera from cow milk-allergic patients. Alanine scanning of immunodominant epitopes was used to identify the critical amino acid (aa). Our initial data revealed Val(8) , Phe(9) , Arg(10) , Tyr(103) , Leu(105) , and His(107) were the critical aa for IgE-binding epitope...
October 2016: Journal of Food Science
Victoria J Martin, Wayne G Shreffler, Qian Yuan
BACKGROUND The prevalence of allergic diseases has been dramatically rising in the United States and other developed nations over recent decades. Growing evidence suggests a partial role for the microbiome in the development of these allergic diseases. Food protein-induced allergic proctocolitis (AP) (also referred to as cow's milk protein intolerance or allergy) is among the earliest and most common food allergic diseases of infancy, yet its pathophysiology is not well understood. The currently accepted clinical practice is to restrict the diet until 12 months of age...
2016: American Journal of Case Reports
Christine Prell, Berthold Koletzko
BACKGROUND: Proper infant nutrition promotes healthy growth and development and lowers the risk of disease in later life. METHODS: This review is based on pertinent articles retrieved by a selective search, including guidelines, meta-analyses, and systematic reviews. RESULTS: Infants should be exclusively breast-fed until at least the age of 4 months. Infants who are no longer being breast-fed, or no longer exclusively so, should be given commercially available low-protein infant formula containing long-chain polyunsaturated fatty acids...
June 24, 2016: Deutsches Ärzteblatt International
Gianluca Picariello, Francesco Addeo, Pasquale Ferranti, Rita Nocerino, Lorella Paparo, Annalisa Passariello, David C Dallas, Randall C Robinson, Daniela Barile, Roberto Berni Canani
Exclusively breast-fed infants can exhibit clear signs of IgE or non IgE-mediated cow's milk allergy. However, the definite characterization of dietary cow's milk proteins (CMP) that survive the maternal digestive tract to be absorbed into the bloodstream and secreted into breast milk remains missing. Herein, we aimed at assessing possible CMP-derived peptides in breast milk. Using high performance liquid chromatography (HPLC)-high resolution mass spectrometry (MS), we compared the peptide fraction of breast milk from 12 donors, among which 6 drank a cup of milk daily and 6 were on a strict dairy-free diet...
August 10, 2016: Food & Function
Alexandre Lapillonne, Maroun Matar, Ariane Adleff, Marwa Chbihi, Elsa Kermorvant-Duchemin, Florence Campeotto
OBJECTIVE: To evaluate the prevalence of and reasons for using extensively hydrolysed formulas (EHFs) of cow's milk proteins in the French neonatal units as well as the modality of their prescription for refeeding infants recovering from necrotising enterocolitis (NEC). METHODS: A multicentre nationwide cross-sectional study using a questionnaire to address the prevalence of use and the reasons for prescribing EHF in hospitalised neonates and to examine the protocols and the actual reasons for their use for refeeding infants in recovery from NEC...
2016: BMJ Open
Liat Nachshon, Yitzhak Katz
The necessity of milk consumption in the western diet is a subject of intense controversy. One of the main benefits of milk is that it is the main source of dietary calcium. Calcium is a major bone mineral, mandatory for bone health. Its supply is derived exclusively from external dietary sources. During the growth period, an increased calcium supply is needed for the process of bone mass accumulation. An optimal bone mass achieved by the end of the growth period may be protective later in life against the bone mass loss that commonly occurs...
March 2016: Harefuah
Kate Maslin, Erin M Oliver, Karen S Scally, Josh Atkinson, Keith Foote, Carina Venter, Graham Roberts, Kate E C Grimshaw
BACKGROUND: Infants with suspected cows' milk allergy are required to follow a strict milk exclusion diet which may lead to nutritional deficiencies, especially if not supervised by a healthcare professional. The aim of this study was to assess the nutritional adequacy of a cows' milk exclusion diet in a group of UK infants over a period of 6 months. METHODS: Participants in this study are a subgroup of the Prevalence of Infant Food Allergy study, a prospective food allergy birth cohort study from the South of England...
2016: Clinical and Translational Allergy
Andrea Lo Vecchio, Yvan Vandenplas, Marc Benninga, Ilse Broekaert, Jackie Falconer, Frederic Gottrand, Carlos Lifschitz, Paolo Lionetti, Rok Orel, Alexandra Papadopoulou, Carmen Ribes-Koninckx, Silvia Salvatore, Raanan Shamir, Michela Schäppi, Annamaria Staiano, Hania Szajewska, Nikhil Thapar, Michael Wilschanski, Alfredo Guarino
AIM: Implementing international guidelines guarantees high standards of clinical care. A group of experts developed an algorithm to drive the management of common gastrointestinal symptoms in infancy by paediatricians and general practitioners. METHODS: The algorithm started from the evidence-based recommendations of the European Society of Gastroenterology, Hepatology and Nutrition and the European Society of Pediatric Infectious Diseases and an updated review of the literature...
August 2016: Acta Paediatrica
Raheleh Shokouhi Shoormasti, Mohammad Reza Fazlollahi, Saeedeh Barzegar, Pegah Teymourpour, Zahra Yazdanyar, Zahra Lebaschi, Maryam Nourizadeh, Behnaz Tazesh, Masoud Movahedi, Homa Kashani, Zahra Pourpak, Mostafa Moin
Cow's milk allergy (CMA) is an immunological response to cow's milk proteins such as casein, α-lactalbumin and β lactoglobulin. The aim of this study was to determine the most common cow's milk allergenic proteins in patients with CMA and identify the most effective proteins in different allergic symptoms. Eighty seven patients (≤18 years) with allergy to cow's milk from 2006 to 2013 entered this study. They had a positive history of allergic reactions to cow's milk and a positive specific IgE test to whole cow's milk...
April 2016: Iranian Journal of Allergy, Asthma, and Immunology
Pipop Jirapinyo, Narumon Densupsoontorn, Channagan Kangwanpornsiri, Renu Wongarn, Hathaichanok Tirapongporn, Kwanjai Chotipanang, Phakkanan Phuangphan
BACKGROUND: Prevalence and severity of cow's milk protein allergy (CMA) in infants are increasing. A proportion of infants with CMA still elicit signs and symptoms of CMA while ingesting commercial amino acid-based formulas (AAFs). We propose that protein in glucose polymers (GPs) derived from corn starch in the AAFs might be the cause of intolerance to AAF in some infants. We thus have produced small molecules of GPs from rice starch, eliminating the protein fraction from them, and subsequently used them as the sole source of carbohydrate in a new amino acid-based formula (NAAF)...
April 11, 2016: Nutrition in Clinical Practice
Neha Khanna, Kirtika Patel
Purpose of Review. The aim of this review is to provide a case driven presentation of the presenting features and diagnostic criteria particularly focusing on the management of FPIES. It also summarises the natural history and resolution of cow's milk induced FPIES. Data Sources. OvidSP Database was used to search for literature using the keywords food protein-induced enterocolitis and FPIES. Recent Findings. The diagnosis of FPIES is often delayed following two or more presentations. Symptoms in the acute form include profuse vomiting usually 2-6 hours following ingestion of food...
2016: Case Reports in Pediatrics
Mauro Batista de Morais
OBJECTIVE: To analyze the development and prevalence of gastrointestinal signs and symptoms associated with the development of the digestive tract, and to assess the measures aimed to reduce their negative impacts. SOURCE OF DATA: Considering the scope and comprehensiveness of the subject, a systematic review of the literature was not carried out. The Medline database was used to identify references that would allow the analysis of the study topics. SYNTHESIS OF RESULTS: Infants frequently show several gastrointestinal signs and symptoms...
May 2016: Jornal de Pediatria
Alexandre Charcosset, Karine Adel-Patient, Christophe Dupont, Hervé Bernard
Specific IgE and IgG4 have been reported to play key roles in the context of IgE-mediated cow's milk allergy (CMA), but the persistence of their epitopes in milk hydrolysates has not been evaluated. Using sera from 32 CMA patients, 6 CMA patients treated by epicutaneous therapy (CM-treated), and 4 CM-tolerant peanut allergic patients, we analyzed the IgE and IgG4 binding capacities related to major milk allergens in processed milk. Different proteases (plasmin, chymosin, α-chymotrypsin, or pepsin) were used progressively and selectively to hydrolyze β-lactoglobulin (β-LG) and casein (CN) in milk...
May 4, 2016: Journal of Agricultural and Food Chemistry
Michael R Perkin, Kirsty Logan, Anna Tseng, Bunmi Raji, Salma Ayis, Janet Peacock, Helen Brough, Tom Marrs, Suzana Radulovic, Joanna Craven, Carsten Flohr, Gideon Lack
BACKGROUND: The age at which allergenic foods should be introduced into the diet of breast-fed infants is uncertain. We evaluated whether the early introduction of allergenic foods in the diet of breast-fed infants would protect against the development of food allergy. METHODS: We recruited, from the general population, 1303 exclusively breast-fed infants who were 3 months of age and randomly assigned them to the early introduction of six allergenic foods (peanut, cooked egg, cow's milk, sesame, whitefish, and wheat; early-introduction group) or to the current practice recommended in the United Kingdom of exclusive breast-feeding to approximately 6 months of age (standard-introduction group)...
May 5, 2016: New England Journal of Medicine
Arnon Elizur, Yitzhak Katz
PURPOSE OF REVIEW: Until recently, nutritional guidelines did not support early introduction of allergenic foods into the diet of high-risk infants. Following recent studies, this approach is beginning to change, at least for peanuts. This review will examine the change in nutritional guidelines and the scientific data that led to these changes. RECENT FINDING: In a recent prospective controlled study, regular consumption of peanut protein in infants from 4-11 months of age with atopic dermatitis or egg allergy, was associated with lower prevalence of peanut allergy (1...
April 2016: Current Opinion in Allergy and Clinical Immunology
Ángela María Candreva, Paola Lorena Smaldini, Renata Curciarello, Carlos Alberto Fossati, Guillermo Horacio Docena, Silvana Petruccelli
Reactions to soy have been reported in a proportion of patients with IgE-mediated cow's milk allergy (CMA). In this work, we analyzed if Gly m Bd 28K/P28, one of the major soybean allergens, is a cross-reactive allergen with cow milk proteins (CMP). We showed that P28 was recognized by IgE sera from CMA patients and activated human peripheral basophils degranulation. Moreover, IgE sera of mice exclusively sensitized to CMP recognized P28. Splenocytes from sensitized animals secreted IL-5 and IL-13 when incubated with CMP or soy proteins, but only IL-13 when treated with P28...
February 24, 2016: Journal of Agricultural and Food Chemistry
A-Ram Kim, Hyuk Soon Kim, Do Kyun Kim, Seung Taek Nam, Hyun Woo Kim, Young Hwan Park, Dajeong Lee, Min Bum Lee, Jun Ho Lee, Bokyung Kim, Michael A Beaven, Hyung Sik Kim, Young Mi Kim, Wahn Soo Choi
Food allergy is a hypersensitive immune reaction to food proteins. We have previously demonstrated the presence of IL-10-producing CD5(+) B cells and suggested their potential role in regulating cow's milk casein allergy in humans and IgE-mediated anaphylaxis in mice. In this study, we determined whether IL-10-producing CD5(+) regulatory B cells control casein-induced food allergic responses in mice and, if so, the underlying mechanisms. The induction of oral tolerance (OT) by casein suppressed casein-induced allergic responses including the decrease of body temperature, symptom score, diarrhea, recruitment of mast cells and eosinophils into jejunum, and other biological parameters in mice...
2016: Scientific Reports
Dominique Turck
Cow's milk is increasingly suggested to play a role in the development of chronic degenerative, non-communicable disorders whereas goat's milk is advocated as having several health benefits. Cow's milk is a rich and cheap source of protein and calcium, and a valuable food for bone health. Despite their high content in saturated fats, consumption of full-fat dairy products does not seem to cause significant changes in cardiovascular disease risk variables. Early introduction of cow's milk is a strong negative determinant of iron status...
2013: World Review of Nutrition and Dietetics
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