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Deep Brain Stimulation Obsessive Compulsive Disorder

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https://www.readbyqxmd.com/read/29217994/local-fields-in-human-subthalamic-nucleus-track-the-lead-up-to-impulsive-choices
#1
John M Pearson, Patrick T Hickey, Shivanand P Lad, Michael L Platt, Dennis A Turner
The ability to adaptively minimize not only motor but cognitive symptoms of neurological diseases, such as Parkinson's Disease (PD) and obsessive-compulsive disorder (OCD), is a primary goal of next-generation deep brain stimulation (DBS) devices. On the basis of studies demonstrating a link between beta-band synchronization and severity of motor symptoms in PD, the minimization of beta band activity has been proposed as a potential training target for closed-loop DBS. At present, no comparable signal is known for the impulsive side effects of PD, though multiple studies have implicated theta band activity within the subthalamic nucleus (STN), the site of DBS treatment, in processes of conflict monitoring and countermanding...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29177631/manipulating-an-internal-pulse-generator-until-twiddler-s-syndrome-in-a-patient-treated-with-deep-brain-stimulation-for-obsessive-compulsive-disorder
#2
Andrea Franzini, Rebecca Ranieri, Orsola Gambini, Giuseppe Messina
BACKGROUND: Twiddler's syndrome consists of rotation or manipulation of an implantable pulse generator (IPG) in its subcutaneous pocket by a patient, thus causing hardware malfunction. METHODS: This syndrome is being reported more frequently in patients treated with deep brain stimulation (DBS). RESULTS: We report the case of a woman who had received bed nucleus of stria terminalis (BNST) electrodes for obsessive-compulsive disorder (OCD) and developed twiddler's syndrome a few months after surgery, causing hardware malfunction due to obsessive manipulation of the IPG...
November 25, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29152502/target-specific-deep-brain-stimulation-of-the-ventral-capsule-ventral-striatum-for-the-treatment-of-neuropsychiatric-disease
#3
Chencheng Zhang, Dianyou Li, Haiyan Jin, Kristina Zeljic, Bomin Sun
Deep brain stimulation (DBS) is a well-established therapy for Parkinson's disease and other movement disorders. An accumulating body of evidence supports the extension of DBS application for the treatment of refractory psychiatric disorders. The ventral capsule/ventral striatum (VC/VS) is the most common anatomical target for obsessive-compulsive disorder (OCD), addiction, and depression. However, no specific electrode is available for the clinical targeting of these areas for DBS. According to the anatomical features of the VC/VS, a novel electrode was developed for simultaneous and independently programmed stimulation of the nucleus accumbens (NAc) and the anterior limb of the internal capsule (ALIC)...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29077804/neuropsychological-and-neuropsychiatric-features-of-idiopathic-and-dyt1-dystonia-and-the-impact-of-medical-and-surgical-treatment
#4
Marjan Jahanshahi
Dystonia is a hyperkinetic movement disorder, characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. Executive dysfunction is a feature of cognitive function in idiopathic and DYT1 dystonia. Psychiatric morbidity is increased in dystonia, and depression, anxiety, obsessive compulsive disorders are the most common disorders. Sleep problems and pain are also frequently experienced. Evidence suggest that mood and anxiety disorders are intrinsic to the neurobiology of dystonia, but also that psychiatric co-morbidity can be secondary to pain experience and the psychosocial functioning and quality of life of the patients...
November 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29077144/-ethical-issues-relating-to-deep-brain-stimulation-for-psychiatric-disorders
#5
A F G Leentjens, D Horstkötter, G de Wert
Deep brain stimulation (dbs) can improve the quality of life of patients with therapy-resistant obsessive compulsive disorder (ocd). For other psychiatric indications, dbs should still be regarded as an experimental treatment.<br/> AIM: To discuss potential ethical issues associated with the use of dbs in the treatment of psychiatric disorders.<br/> METHOD: Ethical discourse.<br/> RESULTS: The ethical issues associated with the use of dbs to treat psychiatric disorders are no different from those that may arise during psychotherapeutic or pharmacological treatments...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29077140/-deep-brain-stimulation-in-psychiatry
#6
M Figee, C Bervoets, D Denys
BACKGROUND: Deep brain stimulation (DBS) is now used regularly to treat therapy-refractory obsessive-compulsive disorders, and is being applied experimentally for refractory depression, Tourette syndrome, addiction, eating disorders, post-traumatic stress disorder, autism and schizophrenia. AIM: To review the effects and mechanisms of dbs and to consider the future opportunities for this type of treatment in psychiatry. METHOD: We reviewed the literature using PubMed...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29034243/improving-surgical-outcome-using-diffusion-tensor-imaging-techniques-in-deep-brain-stimulation
#7
REVIEW
Angela An Qi See, Nicolas Kon Kam King
INTRODUCTION: Recent advances in surgical imaging include the use of diffusion tensor imaging (DTI) in deep brain stimulation (DBS) and provide a detailed view of the white matter tracts and their connections which are not seen with conventional magnetic resonance imaging. Given that the efficacy of DBS depends on the precise and accurate targeting of these circuits, better surgical planning using information obtained from DTI may lead to improved surgical outcome. We aim to review the available literature to evaluate the efficacy of such a strategy...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/29018554/psychiatric-neurosurgery-in-the-21st-century-overview-and-the-growth-of-deep-brain-stimulation
#8
REVIEW
Kenneth Barrett
Ambulatory deep brain stimulation (DBS) became possible in the late 1980s and was initially used to treat people with movement disorders. Trials of DBS in people with treatment-resistant psychiatric disorder began in the late 1990s, initially focusing on obsessive-compulsive disorder, major depressive disorder and Tourette syndrome. Despite methodological issues, including small participant numbers and lack of consensus over brain targets, DBS is now being trialled in a wide range of psychiatric conditions...
October 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/29017175/body-weight-changes-after-deep-brain-stimulation-for-obsessive-compulsive-disorder-or-depression
#9
Rosalie S N Linssen, Marloes S Oudijn, Mariska Mantione, Pepijn van den Munckhof, Damiaan Denys, P Richard Schuurman
BACKGROUND: In 2010, we published an often-cited case report describing smoking cessation and substantial weight loss after deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) in an obese patient. To test whether this single observation was also observed in the treated population at large, the weight changes of a larger cohort of patients who underwent DBS for OCD or major depressive disorder (MDD) were studied. RESULTS: Data were available for 46 patients (30 OCD and 16 MDD patients; mean age 46...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28965430/deep-brain-stimulation-for-severe-treatment-resistant-obsessive-compulsive-disorder-an-open-label-case-series
#10
Sarah Farrand, Andrew H Evans, Simone Mangelsdorf, Samantha M Loi, Ramon Mocellin, Adam Borham, JoAnne Bevilacqua, Scott Blair-West, Mark A Walterfang, Richard G Bittar, Dennis Velakoulis
OBJECTIVE: Deep brain stimulation can be of benefit in carefully selected patients with severe intractable obsessive-compulsive disorder. The aim of this paper is to describe the outcomes of the first seven deep brain stimulation procedures for obsessive-compulsive disorder undertaken at the Neuropsychiatry Unit, Royal Melbourne Hospital. The primary objective was to assess the response to deep brain stimulation treatment utilising the Yale-Brown Obsessive Compulsive Scale as a measure of symptom severity...
September 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28953851/is-there-potential-for-repetitive-transcranial-magnetic-stimulation-rtms-as-a-treatment-of-ocd
#11
Rashid Zaman, Trevor W Robbins
Obsessive-Compulsive Disorder (OCD) is a common and highly debilitating psychiatric disorder. Amongst OCD sufferers are a significant number (40-60%) of so-called non-responders who do not fully respond to commonly available treatments, which include medications (Selective Serotonin Reuptake Inhibitors-SSRIs) and cognitive behavior therapy (CBT). Modern 'neuromodulatory' techniques such as Deep Brain Stimulation (DBS), repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS) potentially offer alternative forms of treatment for OCD patients who either do not respond to, or are unable or unwilling to take SSRIs and undergo CBT...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28930542/deep-brain-stimulation-foundations-and-future-trends
#12
David J Aum, Travis S Tierney
Deep brain stimulation (DBS) has emerged as a revolutionary treatment option for essential tremor (ET), Parkinson's disease (PD), idiopathic dystonia, and severe obsessive-compulsive disorder (OCD). This article reviews the historical foundations of DBS including basal ganglia pathophysiological models, classic principles of electrical stimulation, technical components of the DBS system, treatment risks, and future directions for DBS. Chronic high frequency stimulation induces a number of functional changes from fast physiological to slower metabolic effects and ultimately leads to structural reorganization of the brain, so-called neuroplasticity...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28885367/compulsive-skin-picking-behavior-after-deep-brain-stimulation-in-a-patient-with-refractory-obsessive-compulsive-disorder-a-case-report
#13
Chun-Hung Chang, Shin-Yuan Chen, Sheng-Tzung Tsai, Hsin-Chi Tsai
RATIONAL: The therapeutic effect of deep brain stimulation (DBS) for refractory obsessive-compulsive disorder (OCD) has been studied, but complications after this treatment have rarely been noted. PATIENT CONCERNS: A 28-year-old man with treatment-resistant OCD received bilateral ventral capsule/ventral striatum stimulation for 12 months. DIAGNOSIS: Compulsive skin-picking behavior and infection were noted following 12-month DBS treatment...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28859566/history-of-psychosurgery-at-sainte-anne-hospital-paris-france-through-translational-interactions-between-psychiatrists-and-neurosurgeons
#14
Marc Zanello, Johan Pallud, Nicolas Baup, Sophie Peeters, Baris Turak, Marie Odile Krebs, Catherine Oppenheim, Raphael Gaillard, Bertrand Devaux
Sainte-Anne Hospital is the largest psychiatric hospital in Paris. Its long and fascinating history began in the 18th century. In 1952, it was at Sainte-Anne Hospital that Jean Delay and Pierre Deniker used the first neuroleptic, chlorpromazine, to cure psychiatric patients, putting an end to the expansion of psychosurgery. The Department of Neuro-psychosurgery was created in 1941. The works of successive heads of the Neurosurgery Department at Sainte-Anne Hospital summarized the history of psychosurgery in France...
September 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28826410/altered-functional-connectivity-of-the-subthalamus-and-the-bed-nucleus-of-the-stria-terminalis-in-obsessive-compulsive-disorder
#15
M Cano, P Alonso, I Martínez-Zalacaín, M Subirà, E Real, C Segalàs, J Pujol, N Cardoner, J M Menchón, C Soriano-Mas
BACKGROUND: The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of other clinically-effective DBS targets have not been explored. Here we evaluated the FC patterns of the subthalamic nucleus (STN) and the bed nucleus of the stria terminalis (BNST) in patients with OCD, as well as their association with symptom severity...
August 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28807495/the-colorful-spectrum-of-tourette-syndrome-and-its-medical-surgical-and-behavioral-therapies
#16
Jan Roth
Tourette syndrome (TS) is a common neuropsychiatric disorder, more common in males than females, with onset before age 18. TS is characterized by multiple motor tics and one or more vocal/phonic tics, persisting for more than a year. Tics are unvoluntary, abrupt, rapid, repetitive, but non-rhythmic movements or sounds (vocalizations). They are preceded by an inner urge. Tics can be temporarily suppressed, but this leads to a powerful re-emergence. The performance of tics results in immediate but transient relief...
August 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28791332/deep-brain-stimulation-of-the-subthalamic-nucleus-selectively-decreases-risky-choice-in-risk-preferring-rats
#17
Wendy K Adams, Cole Vonder Haar, Melanie Tremblay, Paul J Cocker, Mason M Silveira, Sukhbir Kaur, Christelle Baunez, Catharine A Winstanley
Deep brain stimulation of the subthalamic nucleus (STN-DBS) can improve the motor symptoms of Parkinson's disease (PD) and negate the problematic side effects of dopamine replacement therapy. Although there is concern that STN-DBS may enhance the development of gambling disorder and other impulse control disorders in this patient group, recent data suggest that STN-DBS may actually reduce iatrogenic impulse control disorders, and alleviate obsessive-compulsive disorder (OCD). Here, we sought to determine whether STN-DBS was beneficial or detrimental to performance of the rat gambling task (rGT), a rodent analogue of the Iowa Gambling Task (IGT) used to assess risky decision making clinically...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28781911/deep-brain-stimulation-for-psychiatric-disorders-is-there-an-impact-on-social-functioning
#18
REVIEW
Christian Saleh, Gregor Hasler
BACKGROUND: Deep brain stimulation (DBS) for refractory psychiatric disorders shows promising effects on symptom-reduction, however, little is known regarding the effects of DBS on social outcome. METHODS: A PubMed search based on original studies of DBS for psychiatric disorders [treatment resistant depression (TRD), Gilles de la Tourette's syndrome (GTS), and obsessive compulsive disorder (OCD)] was conducted. Data on social outcome following surgery were extracted and analyzed...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28752857/insights-into-the-mechanisms-of-deep-brain-stimulation
#19
REVIEW
Keyoumars Ashkan, Priya Rogers, Hagai Bergman, Ismail Ughratdar
Despite long-term and widespread use of deep brain stimulation (DBS) in a variety of neurological conditions, the underlying mechanisms of action have been elusive. Growing evidence suggests that DBS acts through multimodal mechanisms that are not limited to inhibition and excitation of basal ganglia circuits. DBS also seems to act over variable time spans - for example, the effects on tremor are immediate, whereas the effects on dystonia emerge over several weeks - suggesting that large networks are targeted...
September 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28742903/deep-brain-stimulation-for-obsessive-compulsive-disorder-reply
#20
LETTER
Matthew E Hirschtritt, Michael H Bloch, Carol A Mathews
No abstract text is available yet for this article.
July 25, 2017: JAMA: the Journal of the American Medical Association
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