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Deep Brain Stimulation Obsessive Compulsive Disorder

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https://www.readbyqxmd.com/read/27891112/deep-brain-stimulation-for-tourette-s-syndrome-the-case-for-targeting-the-thalamic-centromedian-parafascicular-complex
#1
REVIEW
Paola Testini, Hoon-Ki Min, Asif Bashir, Kendall H Lee
Tourette's syndrome (TS) is a neurologic condition characterized by both motor and phonic tics and is typically associated with psychiatric comorbidities, including obsessive-compulsive disorder/behavior and attention-deficit hyperactivity disorder, and can be psychologically and socially debilitating. It is considered a disorder of the cortico-striato-thalamo-cortical circuitry, as suggested by pathophysiology studies and therapeutic options. Among these, deep brain stimulation (DBS) of the centromedian-parafascicular nucleus (CM-Pf) of the thalamus is emerging as a valuable treatment modality for patients affected by severe, treatment-resistant TS...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27783238/putting-the-pieces-together-in-gilles-de-la-tourette-syndrome-exploring-the-link-between-clinical-observations-and-the-biological-basis-of-dysfunction
#2
REVIEW
Rowshanak Hashemiyoon, Jens Kuhn, Veerle Visser-Vandewalle
Gilles de la Tourette syndrome is a complex, idiopathic neuropsychiatric disorder whose pathophysiological mechanisms have yet to be elucidated. It is phenotypically heterogeneous and manifests more often than not with both motor and behavioral impairment, although tics are its clinical hallmark. Tics themselves present with a complex profile as they characteristically wax and wane and are often preceded by premonitory somatosensory sensations to which it is said a tic is the response. Highly comorbid with obsessive-compulsive disorder and attention deficit-hyperactivity disorder, it is purported to be an epigenetic, neurodevelopmental spectrum disorder with a complex genetic profile...
October 25, 2016: Brain Topography
https://www.readbyqxmd.com/read/27761641/impulse-control-behaviors-and-subthalamic-deep-brain-stimulation-in-parkinson-disease
#3
Aristide Merola, Alberto Romagnolo, Laura Rizzi, Mario Giorgio Rizzone, Maurizio Zibetti, Michele Lanotte, George Mandybur, Andrew P Duker, Alberto J Espay, Leonardo Lopiano
To determine the clinical and demographic correlates of persistent, remitting, and new-onset impulse control behaviors (ICBs) before and after subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We compared the pre- and post-surgical prevalence of ICBs, classified as impulse control disorders (ICD), dopamine dysregulation syndrome (DDS), and punding in 150 consecutive PD STN-DBS-treated patients and determined the association with motor, cognitive, neuropsychological, and neuropsychiatric endpoints...
October 19, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27754484/modulation-of-motor-inhibition-by-subthalamic-stimulation-in-obsessive-compulsive-disorder
#4
A Kibleur, G Gras-Combe, D Benis, J Bastin, T Bougerol, S Chabardès, M Polosan, O David
High-frequency deep brain stimulation of the subthalamic nucleus can be used to treat severe obsessive-compulsive disorders that are refractory to conventional treatments. The mechanisms of action of this approach possibly rely on the modulation of associative-limbic subcortical-cortical loops, but remain to be fully elucidated. Here in 12 patients, we report the effects of high-frequency stimulation of the subthalamic nucleus on behavior, and on electroencephalographic responses and inferred effective connectivity during motor inhibition processes involved in the stop signal task...
October 18, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27745541/patient-preferences-and-acceptability-of-evidence-based-and-novel-treatments-for-obsessive-compulsive-disorder
#5
Sapana R Patel, Hanga Galfavy, Marcia B Kimeldorf, Lisa B Dixon, Helen Blair Simpson
OBJECTIVE: This study examined preferences for and acceptability of treatments for obsessive-compulsive disorder (OCD). METHODS: Through an online survey, adults who self-reported OCD chose their preferred evidence-based treatments, rated acceptability of novel treatments, and answered open-ended questions about their preferences. Analyses examined associations between demographic, clinical, and treatment variables and first-line and augmentation treatment preferences...
October 17, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27699212/reduced-vglut2-slc17a6-gene-expression-levels-throughout-the-mouse-subthalamic-nucleus-cause-cell-loss-and-structural-disorganization-followed-by-increased-motor-activity-and-decreased-sugar-consumption
#6
Nadine Schweizer, Thomas Viereckel, Casey J A Smith-Anttila, Karin Nordenankar, Emma Arvidsson, Souha Mahmoudi, André Zampera, Hanna Wärner Jonsson, Jonas Bergquist, Daniel Lévesque, Åsa Konradsson-Geuken, Malin Andersson, Sylvie Dumas, Åsa Wallén-Mackenzie
The subthalamic nucleus (STN) plays a central role in motor, cognitive, and affective behavior. Deep brain stimulation (DBS) of the STN is the most common surgical intervention for advanced Parkinson's disease (PD), and STN has lately gained attention as target for DBS in neuropsychiatric disorders, including obsessive compulsive disorder, eating disorders, and addiction. Animal studies using STN-DBS, lesioning, or inactivation of STN neurons have been used extensively alongside clinical studies to unravel the structural organization, circuitry, and function of the STN...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27642815/effectiveness-and-adverse-effects-of-deep-brain-stimulation-umbrella-review-of-meta-analyses
#7
Panagiotis N Papageorgiou, James Deschner, Spyridon N Papageorgiou
Background This umbrella review summarizes the evidence across meta-analyses regarding the effectiveness and adverse effects of deep brain stimulation (DBS). Methods Databases were searched up to March 2015 for meta-analyses of comparative trials in humans assessing the effectiveness or adverse effects of DBS. Data selection, data extraction, and risk of bias assessment were performed by two independent reviewers. Results Seven eligible systematic reviews were included assessing the use of DBS for epilepsy (n = 1), obsessive-compulsive disorder (n = 1), and Parkinson disease (n = 5)...
September 19, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27634495/schizophrenia-and-neurosurgery-a-dark-past-with-hope-of-a-brighter-future
#8
Prateek Agarwal, Christina E Sarris, Yehuda Herschman, Nitin Agarwal, Antonios Mammis
Schizophrenia is a chronic and progressive psychiatric disease that remains difficult to manage in the 21st century. Current medical therapies have been able to give reprieve and decrease incidence of psychotic episodes. However, as the disease progresses, patients can become ever more refractory to current pharmaceutical agents and the polypharmacy that is attempted in treatment. Additionally, many of these drugs have significant adverse effects, leaving the practitioner in a difficult predicament for treating these patients...
September 12, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27583182/the-pros-and-cons-of-intraoperative-ct-scan-in-evaluation-of-deep-brain-stimulation-lead-implantation-a-retrospective-study
#9
Domenico Servello, Edvin Zekaj, Christian Saleh, Claudio Pacchetti, Mauro Porta
BACKGROUND: Deep brain stimulation (DBS) is an established therapy for movement disorders, such as Parkinson's disease (PD), dystonia, and tremor. The efficacy of DBS depends on the correct lead positioning. The commonly adopted postoperative radiological evaluation is performed with computed tomography (CT) scan and/or magnetic resonance imaging (MRI). METHODS: We conducted a retrospective study on 202 patients who underwent DBS from January 2009 to October 2013...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27551867/-not-available
#10
Matilda Naesström, Patric Blomstedt, Owe Bodlund
Deep brain stimulation for psychiatric disorders Deep brain stimulation is an established treatment for movement disorders. It has been proven to be a safe method; only minor complications have been reported in larger studies. New indications for deep brain stimulation are under investigation; among them major depressive disorder and obsessive-compulsive disorder. Deep brain stimulation for severe and therapy-resistant major depressive disorder and obsessive compulsive-disorder shows promising results. However, the experience of deep brain stimulation in psychiatric disorders is limited...
2016: Läkartidningen
https://www.readbyqxmd.com/read/27504631/deep-brain-stimulation-of-medial-dorsal-and-ventral-anterior-nucleus-of-the-thalamus-in-ocd-a-retrospective-case-series
#11
Mohammad Maarouf, Clemens Neudorfer, Faycal El Majdoub, Doris Lenartz, Jens Kuhn, Volker Sturm
BACKGROUND: The current notion that cortico-striato-thalamo-cortical circuits are involved in the pathophysiology of obsessive-compulsive disorder (OCD) has instigated the search for the most suitable target for deep brain stimulation (DBS). However, despite extensive research, uncertainty about the ideal target remains with many structures being underexplored. The aim of this report is to address a new target for DBS, the medial dorsal (MD) and the ventral anterior (VA) nucleus of the thalamus, which has thus far received little attention in the treatment of OCD...
2016: PloS One
https://www.readbyqxmd.com/read/27411228/state-of-the-art-for-deep-brain-stimulation-therapy-in-movement-disorders-a-clinical-and-technological-perspective
#12
Aparna Wagle Shukla, Michael S Okun
Deep brain stimulation (DBS) therapy is a widely used brain surgery that can be applied for many neurological and psychiatric disorders. DBS is American Food and Drug Administration approved for medication refractory Parkinson's disease, essential tremor and dystonia. Although DBS has shown consistent success in many clinical trials, the therapy has limitations and there are well-recognized complications. Thus, only carefully selected patients are ideal candidates for this surgery. Over the last two decades, there have been significant advances in clinical knowledge on DBS...
2016: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/27286467/combined-invasive-subcortical-and-non-invasive-surface-neurophysiological-recordings-for-the-assessment-of-cognitive-and-emotional-functions-in-humans
#13
Carlos Trenado, Saskia Elben, David Petri, Jan Hirschmann, Stefan J Groiss, Jan Vesper, Alfons Schnitzler, Lars Wojtecki
In spite of the success in applying non-invasive electroencephalography (EEG), magneto-encephalography (MEG) and functional magnetic resonance imaging (fMRI) for extracting crucial information about the mechanism of the human brain, such methods remain insufficient to provide information about physiological processes reflecting cognitive and emotional functions at the subcortical level. In this respect, modern invasive clinical approaches in humans, such as deep brain stimulation (DBS), offer a tremendous possibility to record subcortical brain activity, namely local field potentials (LFPs) representing coherent activity of neural assemblies from localized basal ganglia or thalamic regions...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27268576/the-medial-forebrain-bundle-as-a-target-for-deep-brain-stimulation-for-obsessive-compulsive-disorder
#14
Volker A Coenen, Thomas E Schlaepfer, Peter Goll, Peter C Reinacher, Ulrich Voderholzer, Ludger Tebartz van Elst, Horst Urbach, Tobias Freyer
Deep brain stimulation (DBS) is a promising putative modality for the treatment of refractory psychiatric disorders such as major depression and obsessive-compulsive disorder (OCD). Several targets have been posited; however, a clear consensus on differential efficacy and possible modes of action remain unclear. DBS to the supero-lateral branch of the medial forebrain bundle (slMFB) has recently been introduced for major depression (MD). Due to our experience with slMFB stimulation for MD, and because OCD might be related to similar dysfunctions of the reward system, treatment with slMFB DBS seams meaningful...
June 8, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27249078/safety-and-efficacy-of-electroconvulsive-therapy-for-depression-in-the-presence-of-deep-brain-stimulation-in-obsessive-compulsive-disorder
#15
David L Rosenthal, Evan Leibu, Amy S Aloysi, Brian H Kopell, Wayne K Goodman, Charles H Kellner
No abstract text is available yet for this article.
May 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27219079/-in-process-citation
#16
Long Long Chen, Gaston Schechtmann, Patrik Ring, Diana Djurfeldt
Obsessive-compulsive disorder (OCD), characterized by repetitive intrusive thoughts and ritualized behaviors, is a highly debilitating disorder with an estimated lifetime prevalence of about 2 %. Approximately 10 % of these patients have severe symptoms despite having received all available treatments, thus considered treatment refractory. Deep brain stimulation (DBS), a reversible, safe and adaptive method widely used for movement disorders, enables specific targeting of deep brain structures of relevance in OCD...
2016: Läkartidningen
https://www.readbyqxmd.com/read/27168347/obsessive-compulsive-disorder-insights-from-animal-models
#17
Henry Szechtman, Susanne E Ahmari, Richard J Beninger, David Eilam, Brian H Harvey, Henriette Edemann-Callesen, Christine Winter
Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ganglia-thalamo-cortical (CBGTC) circuits and OCD by demonstrating the induction of compulsive behavior with the experimental manipulation of the CBGTC circuit. (2) Parallel use of several animal models is a fruitful paradigm to examine the mechanisms of treatment effects of deep brain stimulation in distinct OCD endophenotypes...
May 7, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27103550/a-systematic-review-of-psychiatric-indications-for-deep-brain-stimulation-with-focus-on-major-depressive-and-obsessive-compulsive-disorder
#18
Matilda Naesström, Patric Blomstedt, Owe Bodlund
BACKGROUND: Deep brain stimulation is a treatment under investigation for a range of psychiatric disorders. It has shown promising results for therapy-refractory obsessive-compulsive disorder (OCD) and major depressive disorder (MDD). Other indications under investigation include Tourette's syndrome, anorexia nervosa and substance use disorders. AIMS: To review current studies on psychiatric indications for deep brain stimulation (DBS), with focus on OCD and MDD...
October 2016: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/27098785/deep-brain-stimulation-of-the-globus-pallidus-internus-in-patients-with-intractable-tourette-syndrome-a-1-year-follow-up-study
#19
Xiao-Hua Zhang, Jian-Yu Li, Yu-Qing Zhang, Yong-Jie Li
BACKGROUND: Deep brain stimulation (DBS) has been a promising treatment for patients with refractory Tourette syndrome (TS) for more than a decade. Despite successful DBS treatment of TS in more than 100 patients worldwide, studies with a large patient sample and long-term follow-up assessments are still scarce. Accordingly, we investigated the clinical efficacy and safety of globus pallidus internus (GPi) DBS in the treatment of intractable TS in 24 patients with a 1-year follow-up assessment...
May 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27086546/an-avoidance-based-rodent-model-of-exposure-with-response-prevention-therapy-for-obsessive-compulsive-disorder
#20
Jose Rodriguez-Romaguera, Benjamin D Greenberg, Steven A Rasmussen, Gregory J Quirk
BACKGROUND: Obsessive-compulsive disorder is treated with exposure with response prevention (ERP) therapy, in which patients are repeatedly exposed to compulsive triggers but prevented from expressing their compulsions. Many compulsions are an attempt to avoid perceived dangers, and the intent of ERP is to extinguish compulsions. Patients failing ERP therapy are candidates for deep brain stimulation (DBS) of the ventral capsule/ventral striatum, which facilitates patients' response to ERP therapy...
October 1, 2016: Biological Psychiatry
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