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Deep Brain Stimulation Obsessive Compulsive Disorder

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https://www.readbyqxmd.com/read/29904585/recent-advances-in-deep-brain-stimulation-in-psychiatric-disorders
#1
REVIEW
Anne-Hélène Clair, William Haynes, Luc Mallet
Deep brain stimulation (DBS) has been offered to patients suffering of severe and resistant neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (TS) and Major Depression (MDD). Modulation of several targets within the cortico-striato-thalamo-cortical circuits can lead to a decrease of symptom severity in those patients. This review focuses on the recent clinical outcomes in DBS in psychiatric disorders. Studies on OCD and TS are now focusing on the long-term effects of DBS, with encouraging results regarding not only the decrease of symptoms, but also quality of life...
2018: F1000Research
https://www.readbyqxmd.com/read/29895269/identity-challenges-and-burden-of-normality-after-dbs-for-severe-ocd-a-narrative-case-study
#2
Peter Bosanac, Bridget Elizabeth Hamilton, James Lucak, David Castle
BACKGROUND: Deep Brain Stimulation (DBS) is an emerging and potentially powerful biological treatment for severe Obsessive-Compulsive Disorder (OCD), but the wider impact of the intervention and the sometimes dramatic reduction in symptoms need greater attention in research and practice. The aim of this case study is to explore the subjective experience of preparing for and undergoing DBS as a treatment for severe and treatment-refractory OCD and the experience of the impact of the treatment...
June 13, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29860948/impulsivity-and-decision-making-in-obsessive-compulsive-disorder-after-effective-deep-brain-stimulation-or-treatment-as-usual
#3
Giacomo Grassi, Martijn Figee, Pieter Ooms, Lorenzo Righi, Takashi Nakamae, Stefano Pallanti, Rick Schuurman, Damiaan Denys
OBJECTIVE: Impulsivity and impaired decision-making have been proposed as obsessive-compulsive disorder (OCD) endophenotypes, running in OCD and their healthy relatives independently of symptom severity and medication status. Deep brain stimulation (DBS) targeting the ventral limb of the internal capsule (vALIC) and the nucleus accumbens (Nacc) is an effective treatment strategy for treatment-refractory OCD. The effectiveness of vALIC-DBS for OCD has been linked to its effects on a frontostriatal network that is also implicated in reward, impulse control, and decision-making...
June 4, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29794060/striatal-dopamine-regulates-systemic-glucose-metabolism-in-humans-and-mice
#4
Kasper W Ter Horst, Nicolette M Lammers, Richard Trinko, Darren M Opland, Martijn Figee, Mariette T Ackermans, Jan Booij, Pepijn van den Munckhof, P Richard Schuurman, Eric Fliers, Damiaan Denys, Ralph J DiLeone, Susanne E la Fleur, Mireille J Serlie
The brain is emerging as an important regulator of systemic glucose metabolism. Accumulating data from animal and observational human studies suggest that striatal dopamine signaling plays a role in glucose regulation, but direct evidence in humans is currently lacking. We present a series of experiments supporting the regulation of peripheral glucose metabolism by striatal dopamine signaling. First, we present the case of a diabetes patient who displayed strongly reduced insulin requirements after treatment with bilateral deep brain stimulation (DBS) targeting the anterior limb of the internal capsule...
May 23, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29751598/informed-consent-decision-making-in-deep-brain-stimulation
#5
REVIEW
Gabriele Mandarelli, Germana Moretti, Massimo Pasquini, Giuseppe Nicolò, Stefano Ferracuti
Deep brain stimulation (DBS) has proved useful for several movement disorders (Parkinson’s disease, essential tremor, dystonia), in which first and/or second line pharmacological treatments were inefficacious. Initial evidence of DBS efficacy exists for refractory obsessive-compulsive disorder, treatment-resistant major depressive disorder, and impulse control disorders. Ethical concerns have been raised about the use of an invasive surgical approach involving the central nervous system in patients with possible impairment in cognitive functioning and decision-making capacity...
May 11, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29736078/deep-brain-stimulation-of-anteromedial-globus-pallidus-internus-for-severe-tourette-syndrome
#6
Paresh K Doshi, Raghvendra Ramdasi, Smita Thorve
Tourette syndrome (TS) is a complex disorder characterized by tics and is associated with behavioral problems. Although its intensity decreases in adolescence and adult life, in some cases it continues to remain severe and refractory to medical treatment. Deep brain stimulation has been offered as a treatment option in such cases. We report two cases of TS treated with of anteromedial globus pallidum internus. Both the cases had good postoperative control of tics and associated obsessive-compulsive behavior...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29723733/positive-clinical-effects-of-gamma-knife-capsulotomy-in-a-patient-with-deep-brain-stimulation-refractory-tourette-syndrome-and-obsessive-compulsive-disorder
#7
Raphaëlle Richieri, Graham Blackman, Richard Musil, Giorgio Spatola, Andrea E Cavanna, Christophe Lançon, Jean Régis
We report the first case of a patient with severe, intractable Tourette Syndrome with comorbid Obsessive Compulsive disorder, who recovered from both disorders with gamma-knife (GK) stereotactic radiosurgery following deep brain stimulation (DBS). This case highlights the possible role of the internal capsule within the neural circuitries underlying both TS and OCD, and suggests that in cases of treatment-refractory TS and comorbid OCD, bilateral anterior capsulotomy using stereotactic radiosurgery may be a viable treatment option...
April 26, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29681866/study-protocol-using-deep-brain-stimulation-multimodal-neuroimaging-and-neuroethics-to-understand-and-treat-severe-enduring-anorexia-nervosa
#8
Rebecca J Park, Jessica C Scaife, Tipu Z Aziz
Background: Research suggests that altered eating and the pursuit of thinness in anorexia nervosa (AN) are, in part, a consequence of aberrant reward circuitry. The neural circuits involved in reward processing and compulsivity overlap significantly, and this has been suggested as a transdiagnostic factor underpinning obsessive compulsive disorder, addictions and eating disorders. The nucleus accumbens (NAcc) is central to both reward processing and compulsivity. In previous studies, deep-brain stimulation (DBS) to the NAcc has been shown to result in neural and symptomatic improvement in both obsessive compulsive disorder and addictions...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29676713/-deep-brain-stimulation-for-psychiatric-disorders
#9
M Figee, P R Schuurman, D Denys
- Deep brain stimulation (DBS) corrects pathological activity of neuropsychiatric brain networks with high frequency current via implanted brain electrodes.- DBS is an effective and safe treatment for therapy-refractory obsessive-compulsive disorder and potentially also for therapy-refractory major depressive disorder.- Experimental psychiatric indications for DBS are Tourette syndrome, addiction, anorexia nervosa, post-traumatic stress disorder, autism and schizophrenia.- DBS influences brain networks that are relevant for a variety of psychiatric symptoms...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29606319/repetitive-movements-and-behaviors-in-neurological-and-psychiatric-practice-distinctions-and-similarities-between-tourette-disorder-and-obsessive-compulsive-disorder
#10
REVIEW
A Hartmann, B Millet
Repetitive movements are the hallmark of chronic tic disorders such as Tourette disorder (TD), whereas repetitive behaviors are characteristic of obsessive-compulsive disorder (OCD). Both disorders tend to frequently co-occur, as a substantial number of patients with TD also suffer from OCD and vice versa. While the clinical distinction between tics and OCD is usually easy, there are borderline forms, and correct symptom recognition is vital for choosing the appropriate treatment modalities for each disorder, be they pharmacological, psychotherapeutic (behavioral therapy) or brain stimulation (deep brain stimulation, repetitive transcranial magnetic stimulation)...
April 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29565177/deep-brain-stimulation-in-obsessive-compulsive-disorder
#11
Peter Bosanac, Susan Rossell, James Olver, Clare Groves, David Castle
No abstract text is available yet for this article.
March 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29559386/dissociable-effects-of-subthalamic-stimulation-in-obsessive-compulsive-disorder-on-risky-reward-and-loss-prospects
#12
Valerie Voon, Fabien Droux, Stephan Chabardes, Thierry Bougerol, Sina Kohl, Olivier David, Paul Krack, Mircea Polosan
Our daily decisions involve an element of risk, a behavioral process that is potentially modifiable. Here we assess the role of the associative-limbic subthalamic nucleus (STN) in obsessive compulsive disorder (OCD) testing on and off deep-brain stimulation (DBS) on anticipatory risk taking to obtain rewards and avoid losses. We assessed 12 OCD STN DBS in a randomized double-blind within-subject cross-over design. STN DBS decreased risk taking to rewards (p = 0.02) and greater risk taking to rewards was positively correlated with OCD severity (p = 0...
March 17, 2018: Neuroscience
https://www.readbyqxmd.com/read/29558564/systems-approaches-to-optimizing-deep-brain-stimulation-therapies-in-parkinson-s-disease
#13
REVIEW
Sabato Santaniello, John T Gale, Sridevi V Sarma
Over the last 30 years, deep brain stimulation (DBS) has been used to treat chronic neurological diseases like dystonia, obsessive-compulsive disorders, essential tremor, Parkinson's disease, and more recently, dementias, depression, cognitive disorders, and epilepsy. Despite its wide use, DBS presents numerous challenges for both clinicians and engineers. One challenge is the design of novel, more efficient DBS therapies, which are hampered by the lack of complete understanding about the cellular mechanisms of therapeutic DBS...
March 20, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29557710/the-subthalamic-nucleus-unravelling-new-roles-and-mechanisms-in-the-control-of-action
#14
Tora Bonnevie, Kareem A Zaghloul
How do we decide what we do? This is the essence of action control, the process of selecting the most appropriate response among multiple possible choices. Suboptimal action control can involve a failure to initiate or adapt actions, or conversely it can involve making actions impulsively. There has been an increasing focus on the specific role of the subthalamic nucleus (STN) in action control. This has been fueled by the clinical relevance of this basal ganglia nucleus as a target for deep brain stimulation (DBS), primarily in Parkinson's disease but also in obsessive-compulsive disorder...
March 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29503332/expanding-indications-for-deep-brain-stimulation
#15
Paresh K Doshi
It has been three decades since the first application of deep brain stimulation (DBS) for tremors was described by Benabid. Over the years, the indications for the performance of DBS have been expanding. There are now more than 1,50,000 patients around the world who have undergone DBS for various disorders. The main appeal of DBS is in its reversibility and titratability. Though the initial interest in DBS was for pain, the main indications for DBS have been movement disorders. Despite its wide appeal and "perceived" advantage, United States Food and Drug Administration, the nodal agency for approving therapies, has been cautious and guarded in providing approvals...
March 2018: Neurology India
https://www.readbyqxmd.com/read/29431884/successes-and-optimism-in-deep-brain-stimulation-for-neurological-disorders-ripe-for-a-surgical-time-out
#16
EDITORIAL
A I Tröster
No abstract text is available yet for this article.
May 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29412526/-obsessive-compulsive-disorder-and-deep-brain-stimulation-a-future-so-close
#17
João Flores Alves Dos Santos, Paul Krack, Shahan Momjian, Guido Bondolfi, Luc Mallet
The obsessive compulsive disorder (OCD) is a psychiatric disorder with a high prevalence (2‑3 %), frequently causing a disabling condition. Drug and psychotherapeutic treatment is generally effective. However about 1/3 of the patients are treatment-resistant, suffering from chronic psychological distress with important sociofunctional repercussions. The identification of dysfunctional neural networks in this disease opens the door to the use of neuromodulation techniques, as deep brain stimulation (DBS)...
February 7, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29406245/progress-and-challenges-in-deep-brain-stimulation-for-obsessive-compulsive-disorder
#18
REVIEW
Sina Kohl, Juan Carlos Baldermann
This narrative review summarizes the recent literature on deep brain stimulation for treatment resistant obsessive-compulsive disorder highlighting both progress and challenges of this novel treatment. Common targets of psychiatric deep brain stimulation involve both white matter trajectories (anterior limb of the internal capsule, inferior thalamic peduncle, and medial forebrain bundle) and grey matter subcortical nuclei (nucleus accumbens, nucleus subthalamicus, and bed nucleus of the stria terminalis) each of which have been reported with a relevant beneficial effect on obsessive-compulsive symptoms...
January 31, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29388475/massive-weight-loss-following-deep-brain-stimulation-of-the-nucleus-accumbens-in-a-depressed-woman
#19
Volker M Tronnier, Dirk Rasche, Veronika Thorns, Daniel Alvarez-Fischer, Thomas F Münte, Bartosz Zurowski
Obese individuals share behavioral characteristics with drug/alcohol addicts as well as obsessive compulsive disease. Deep brain stimulation (DBS) has been used successfully in these disorders, thus warranting an evaluation in obesity. A woman with treatment-resistant depression as well as severe obesity was selected for DBS of the nucleus accumbens (NAcc) bilaterally with depression being the primary and obesity being the secondary target of treatment. Compared to earlier bariatric surgery, the patient showed accelerated weight loss after DBS...
February 2018: Neurocase
https://www.readbyqxmd.com/read/29371415/charting-the-road-forward-in-psychiatric-neurosurgery-proceedings-of-the-2016-american-society-for-stereotactic-and-functional-neurosurgery-workshop-on-neuromodulation-for-psychiatric-disorders
#20
Ausaf A Bari, Charles B Mikell, Aviva Abosch, Sharona Ben-Haim, Robert J Buchanan, Allen W Burton, Stephen Carcieri, G Rees Cosgrove, Pierre-Francois D'Haese, Zafiris Jeffrey Daskalakis, Emad N Eskandar, Jason L Gerrard, Wayne K Goodman, Benjamin David Greenberg, Robert E Gross, Clement Hamani, Zelma H T Kiss, Peter Konrad, Brian H Kopell, Lothar Krinke, Jean-Philippe Langevin, Andres M Lozano, Donald Malone, Helen S Mayberg, Jonathan P Miller, Parag G Patil, DeLea Peichel, Erika A Petersen, Ali R Rezai, R Mark Richardson, Patricio Riva-Posse, Tejas Sankar, Jason M Schwalb, Helen Blair Simpson, Konstantin Slavin, Paul H Stypulkowski, Tor Tosteson, Peter Warnke, Jon T Willie, Kareem A Zaghloul, Joseph S Neimat, Nader Pouratian, Sameer A Sheth
OBJECTIVE: Refractory psychiatric disease is a major cause of morbidity and mortality worldwide, and there is a great need for new treatments. In the last decade, investigators piloted novel deep brain stimulation (DBS)-based therapies for depression and obsessive-compulsive disorder (OCD). Results from recent pivotal trials of these therapies, however, did not demonstrate the degree of efficacy expected from previous smaller trials. To discuss next steps, neurosurgeons, neurologists, psychiatrists and representatives from industry convened a workshop sponsored by the American Society for Stereotactic and Functional Neurosurgery in Chicago, Illinois, in June of 2016...
January 25, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
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