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breast cancer, metastatic, prognostic markers

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https://www.readbyqxmd.com/read/28710396/the-cinsarc-signature-as-a-prognostic-marker-for-clinical-outcome-in-multiple-neoplasms
#1
Tom Lesluyes, Lucile Delespaul, Jean-Michel Coindre, Frédéric Chibon
We previously reported the CINSARC signature as a prognostic marker for metastatic events in soft tissue sarcomas, breast carcinomas and lymphomas through genomic instability, acting as a major factor for tumor aggressiveness. In this study, we used a published resource to investigate CINSARC enrichment in poor outcome-associated genes at pan-cancer level and in 39 cancer types. CINSARC outperformed more than 15,000 defined signatures (including cancer-related), being enriched in top-ranked poor outcome-associated genes of 21 cancer types, widest coverage reached among all tested signatures...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683102/identification-of-prognostic-collagen-signatures-and-potential-therapeutic-stromal-targets-in-canine-mammary-gland-carcinoma
#2
Ashley Case, Becky K Brisson, Amy C Durham, Suzanne Rosen, James Monslow, Elizabeth Buza, Pascale Salah, Julie Gillem, Gordon Ruthel, Sridhar Veluvolu, Veronica Kristiansen, Ellen Puré, Dorothy C Brown, Karin U Sørenmo, Susan W Volk
Increasing evidence indicates that the tumor microenvironment plays a critical role in regulating the biologic behavior of breast cancer. In veterinary oncology, there is a need for improved prognostic markers to accurately identify dogs at risk for local and distant (metastatic) recurrence of mammary gland carcinoma and therefore would benefit from adjuvant therapy. Collagen density and fiber organization have been shown to regulate tumor progression in both mouse and human mammary tumors, with certain collagen signatures predicting poor outcomes in women with breast cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28679654/neoadjuvant-chemotherapy-induces-breast-cancer-metastasis-through-a-tmem-mediated-mechanism
#3
George S Karagiannis, Jessica M Pastoriza, Yarong Wang, Allison S Harney, David Entenberg, Jeanine Pignatelli, Ved P Sharma, Emily A Xue, Esther Cheng, Timothy M D'Alfonso, Joan G Jones, Jesus Anampa, Thomas E Rohan, Joseph A Sparano, John S Condeelis, Maja H Oktay
Breast cancer cells disseminate through TIE2/MENA(Calc)/MENA(INV)-dependent cancer cell intravasation sites, called tumor microenvironment of metastasis (TMEM), which are clinically validated as prognostic markers of metastasis in breast cancer patients. Using fixed tissue and intravital imaging of a PyMT murine model and patient-derived xenografts, we show that chemotherapy increases the density and activity of TMEM sites and Mena expression and promotes distant metastasis. Moreover, in the residual breast cancers of patients treated with neoadjuvant paclitaxel after doxorubicin plus cyclophosphamide, TMEM score and its mechanistically connected MENA(INV) isoform expression pattern were both increased, suggesting that chemotherapy, despite decreasing tumor size, increases the risk of metastatic dissemination...
July 5, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28674207/direct-comparison-study-of-dna-methylation-markers-in-epcam-positive-circulating-tumour-cells-corresponding-circulating-tumour-dna-and-paired-primary-tumours-in-breast-cancer
#4
Maria Chimonidou, Areti Strati, Nikos Malamos, Sophia Kouneli, Vassilis Georgoulias, Evi Lianidou
Circulating Tumour Cells (CTCs) and circulating tumour DNA (ctDNA) represent a non-invasive liquid biopsy approach for the follow-up and therapy management of cancer patients. We evaluated whether DNA methylation status in CTCs and ctDNA is comparable and whether it reflects the status of primary tumours. We compared the methylation status of three genes, SOX17, CST6 and BRMS1 in primary tumours, corresponding CTCs and ctDNA in 153 breast cancer patients and healthy individuals, by using real time methylation specific PCR...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28657611/cspg4-a-target-for-selective-delivery-of-human-cytolytic-fusion-proteins-and-trail
#5
REVIEW
Sandra Jordaan, Shivan Chetty, Neelakshi Mungra, Iris Koopmans, Peter E van Bommel, Wijnand Helfrich, Stefan Barth
Chondroitin-sulfate proteoglycan 4 (CSPG4) is a transmembrane glycoprotein overexpressed on malignant cells in several cancer types with only limited expression on normal cells. CSPG4 is implicated in several signaling pathways believed to drive cancer progression, particularly proliferation, motility and metastatic spread. Expression may serve as a prognostic marker for survival and risk of relapse in treatment-resistant malignancies including melanoma, triple negative breast cancer, rhabdomyosarcoma and acute lymphoblastic leukemia...
June 28, 2017: Biomedicines
https://www.readbyqxmd.com/read/28588612/the-roles-of-carcinoembryonic-antigen-in-liver-metastasis-and-therapeutic-approaches
#6
REVIEW
Joo Han Lee, Seong-Wook Lee
Metastasis is a highly complicated and sequential process in which primary cancer spreads to secondary organic sites. Liver is a well-known metastatic organ from colorectal cancer. Carcinoembryonic antigen (CEA) is expressed in most gastrointestinal, breast, and lung cancer cells. Overexpression of CEA is closely associated with liver metastasis, which is the main cause of death from colorectal cancer. CEA is widely used as a diagnostic and prognostic tumor marker in cancer patients. It affects many steps of liver metastasis from colorectal cancer cells...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28576130/the-g%C3%AE-h-plc%C3%AE-1-signaling-axis-drives-metastatic-progression-in-triple-negative-breast-cancer
#7
Shang-Pen Huang, Pei-Yao Liu, Chih-Jung Kuo, Chi-Long Chen, Wei-Jiunn Lee, Yu-Hui Tsai, Yuan-Feng Lin
BACKGROUND: Distant metastasis of triple-negative breast cancer (TNBC) to other organs, e.g., the lungs, has been correlated with poor survival rates among breast cancer patients. Therefore, the identification of useful therapeutic targets to prevent metastasis or even inhibit tumor growth of TNBC is urgently needed. Gαh is a novel GTP-binding protein and known as an inactive form of calcium-dependent tissue transglutaminase. However, the functional consequences of transamidating and G-protein activities of tissue transglutaminase in promoting cancer metastasis are still controversial...
June 2, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28574279/update-on-immunohistochemical-analysis-in-breast-lesions
#8
Yan Peng, Yasmeen M Butt, Beiyun Chen, Xinmin Zhang, Ping Tang
CONTEXT: - The utility of immunohistochemistry (IHC) in breast lesions needs to be updated with exceptions among these lesions. Biomarker studies with IHC in triple-negative breast carcinoma may help develop targeted therapies for this aggressive breast cancer. The distinction of metastatic lung adenocarcinoma to the breast and invasive breast carcinoma has significant prognostic and therapeutic implications. The determination can be challenging because both primary tumors can express estrogen receptor and/or HER2 by IHC, creating a diagnostic dilemma...
June 2, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28558008/expression-of-anaesthetic-and-analgesic-drug-target-genes-in-excised-breast-tumour-tissue-association-with-clinical-disease-recurrence-or-metastasis
#9
C Connolly, S F Madden, D J Buggy, H C Gallagher
BACKGROUND: Retrospective analyses suggest anaesthetic-analgesics technique during cancer surgery may affect recurrence/metastasis. This could involve direct effects of anaesthetic-analgesic drugs on cancer cells. While μ-opioid receptor over-expression in lung tumours is associated with greater metastasis, other anaesthetic-analgesic receptor targets in cancer recurrence/metastasis remain unexplored. Therefore, we evaluated the association between genetic expression of anaesthetic-analgesic receptor targets and recurrence/metastasis, using a repository of breast cancer gene expression and matching clinical data...
2017: PloS One
https://www.readbyqxmd.com/read/28533055/high-asma-fibroblasts-and-low-cytoplasmic-hmgb1-breast-cancer-cells-predict-poor%C3%A2-prognosis
#10
Kamolporn Amornsupak, Pranisa Jamjuntra, Malee Warnnissorn, Pornchai O-Charoenrat, Doonyapat Sa-Nguanraksa, Peti Thuwajit, Suzanne A Eccles, Chanitra Thuwajit
INTRODUCTION: The influence of cancer-associated fibroblasts (CAFs) and high mobility group box 1 (HMGB1) has been recognized in several cancers, although their roles in breast cancer are unclear. The present study aimed to determine the levels and prognostic significance of α-smooth muscle actin-positive (ASMA(+)) CAFs, plus HMGB1 and receptor for advanced glycation end products (RAGE) in cancer cells. MATERIALS AND METHODS: A total of 127 breast samples, including 96 malignant and 31 benign, were examined for ASMA, HMGB1, and RAGE by immunohistochemistry...
April 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28507762/circulating-tumor-cell-clusters-associated-gene-plakoglobin-is-a-significant-prognostic-predictor-in-patients-with-breast-cancer
#11
Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is positively associated with CTC clusters in breast cancer. In this study, we investigated the correlation between plakoglobin expression and survival of breast cancer. METHODS: We evaluated 121 breast cancer patients treated with neoadjuvant chemotherapy...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28502078/dyrk2-is-a-suppressor-and-potential-prognostic-marker-for-liver-metastasis-of-colorectal-cancer
#12
Daisuke Ito, Satomi Yogosawa, Rei Mimoto, Shinichi Hirooka, Takashi Horiuchi, Ken Eto, Katsuhiko Yanaga, Kiyotsugu Yoshida
Colorectal cancer is a common cancer and a leading cause of cancer-related death worldwide. The liver is a dominant metastatic site for patients with colorectal cancer. Molecular mechanisms that allow colorectal cancer cells to form liver metastases are largely unknown. Activation of epithelial-mesenchymal-transition (EMT) is the key step for metastasis of cancer cells. We have recently demonstrated in breast cancer and ovarian serous adenocarcinoma that dual-specificity tyrosine-regulated kinase 2 (DYRK2) controls EMT...
May 14, 2017: Cancer Science
https://www.readbyqxmd.com/read/28496363/prognostic-value-of-histone-chaperone-fact-subunits-expression-in-breast-cancer
#13
Kristopher Attwood, Daria Fleyshman, Laura Prendergast, Geraldine Paszkiewicz, Angela R Omilian, Wiam Bshara, Katerina Gurova
Understanding the underlying reasons for tumor aggressiveness, such as why some tumors grow slowly and locally, while others rapidly progress to a lethal metastatic disease, is still limited. This is especially critical in breast cancer (BrCa) due to its high prevalence and also due to the possibility that it can be detected early. Several oncogenes and tumor suppressors have been identified and are used in the prognosis and treatment of BrCa. However, even with these markers, the outcome within BrCa subtypes is highly variable...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28481697/hormone-receptor-positive-breast-cancer-highlights-from-the-39-th-san-antonio-breast-cancer-symposium
#14
Giorgia Zucchini, Filippo Montemurro
The San Antonio Breast Cancer Symposium is considered one of the most influential international meetings focusing on breast cancer management, covering several areas of study from basic research to clinical practice topics. a number of oral presentations addressing hormone receptor-positive breast cancer brought new data about critical subjects like the optimal duration of adjuvant endocrine therapy, new prognostic markers and their potential role in guiding adjuvant treatment choices, new insights into genomic alterations acquired during the metastatic process, and pharmacologic strategies to overcome resistance to endocrine therapy...
June 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28442512/the-clinical-value-of-hepcidin-in-breast-cancer-and-its-bone-metastasis
#15
Xiaonan Shao, Fei Cao, Min Tao
PURPOSE: We explored the role of hepcidin in the progression of breast cancer. METHODS: A retrospective analysis of 25 breast cancer patients with bone metastases, 30 breast cancer patients without bone metastases, and 30 patients with breast hyperplasia was conducted to compare the differences in Hb, hepcidin, BMP6, IL-6, and sTfR among the three groups and explore the correlation of Hepcidin with BMP6 IL-6, Hb and sTfR. In addition, ROC analysis was performed to evaluate the diagnostic value of hepcidin, BMP6 and IL-6 in breast cancer and its bone metastasis, while multivariate Logistic regression analysis was conducted to compare various indicators in breast cancer and its bone metastasis...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28387221/a-3q-gene-signature-associated-with-triple-negative-breast-cancer-organ-specific-metastasis-and-response-to-neoadjuvant-chemotherapy
#16
Jun Qian, Heidi Chen, Xiangming Ji, Rosana Eisenberg, A Bapsi Chakravarthy, Ingrid A Mayer, Pierre P Massion
Triple negative breast cancers (TNBC) are aggressive tumors, with high rates of metastatic spread and targeted therapies are critically needed. We aimed to assess the prognostic and predictive value of a 3q 19-gene signature identified previously from lung cancer in a collection of 4,801 breast tumor gene expression data. The 3q gene signature had a strong association with features of aggressiveness such as high grade, hormone receptor negativity, presence of a basal-like or TNBC phenotype and reduced distant metastasis free survival...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28347399/role-of-galnt14-in-lung-metastasis-of-breast-cancer
#17
Mi-Young Kim
Aberrant expression of the polypeptide N-acetyl-galactosaminyltransferase (GALNTs) has been associated with cancer, but their function(s) in metastasis remains elusive. We have recently identified GALNT14, one of the O-GalNAc glycosylationinitiating enzymes, as a prognostic marker for pulmonary relapse in breast cancer patients. Furthermore, we showed that GALNT14 promotes lung metastasis by the following novel mechanisms: 1) enhancing metastasis initiation by inhibiting the anti-metastatic effect of BMP produced from the lung stroma, 2) exploiting growth signals (e...
May 2017: BMB Reports
https://www.readbyqxmd.com/read/28240519/triple-negative-breast-cancer-at-the-university-hospital-mohammed-vi-%C3%A2-oujda
#18
o Al jarroudi, n Abda, Sa Brahmi, S Afqir
Introduction: The triple-negative breast cancer (TNBC), defined by the absence of receptors to oestrogen and progesterone and no histochemical expression of human epidermal receptor -2, is associated with a particularly aggressive behavior. The aim of our study was to determine the clinico-pathological, therapeutic and prognostic features associated with this type of breast cancer in Morocco. Methods: A cohort retrospective study, spread over 3 years, was conducted of 116 breast cancer patients, diagnosed between January 2009 and December 2011 at the Regional Center of Oncology...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28228690/human-cytomegalovirus-interleukin-10-enhances-matrigel-invasion-of-mda-mb-231-breast-cancer-cells
#19
Cendy A Valle Oseguera, Juliet V Spencer
BACKGROUND: While some risk factors for breast cancer are well-known, the influence of other factors, particularly virus infection, remains unclear. Human cytomegalovirus (HCMV) is widespread in the general population, and both molecular and epidemiological evidence has indicated links between HCMV and breast cancer. The HCMV protein cmvIL-10 is a potent suppressor of immune function that has also been shown to promote proliferation and migration of breast cancer cells. In this study, the impact of cmvIL-10 on tumor cell invasion through a simulated basement membrane was investigated...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28218905/phosphorylation-mediated-activation-of-ldha-promotes-cancer-cell-invasion-and-tumour-metastasis
#20
L Jin, J Chun, C Pan, G N Alesi, D Li, K R Magliocca, Y Kang, Z G Chen, D M Shin, F R Khuri, J Fan, S Kang
Metastases remain the major cause of death from cancer. Recent molecular advances have highlighted the importance of metabolic alterations in cancer cells, including the Warburg effect that describes an increased glycolysis in cancer cells. However, how this altered metabolism contributes to tumour metastasis remains elusive. Here, we report that phosphorylation-induced activation of lactate dehydrogenase A (LDHA), an enzyme that catalyses the interconversion of pyruvate and lactate, promotes cancer cell invasion, anoikis resistance and tumour metastasis...
July 6, 2017: Oncogene
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