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https://www.readbyqxmd.com/read/29045833/intestinal-fork-head-regulates-nutrient-absorption-and-promotes-longevity
#1
Ekin Bolukbasi, Mobina Khericha, Jennifer C Regan, Dobril K Ivanov, Jennifer Adcott, Miranda C Dyson, Tobias Nespital, Janet M Thornton, Nazif Alic, Linda Partridge
Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet the underlying biology remains unclear. We show that the anti-aging effects of rapamycin and reduced intestinal insulin/insulin growth factor (IGF) signaling (IIS) require the Drosophila FoxA transcription factor homolog Fork Head (FKH). Intestinal FKH induction extends lifespan, highlighting a role for the gut. FKH binds to and is phosphorylated by AKT and Target of Rapamycin. Gut-specific FKH upregulation improves gut barrier function in aged flies...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29041881/-age-related-changes-of-heart-rate-variability-at-various-insulin-sensitivity-and-telomere-length
#2
A S Boytsov, N O Tkachyeva, I L Streltsova, N E Dudinskaya, U D Akasheva, V E Plokhova, D I Strazhesko
AIM: To study relationship between age-associated changes of heart rate variability (HRV), telomere length (TL), and lowering of insulin sensitivity (IS). MATERIAL AND METHODS: We included in this study 229 individuals aged 23‒91 years without clinical manifestations of cardiovascular and other somatic diseases. In all participants, we analyzed HRV parameters obtained at 24-hour ECG monitoring (24-h ECG) and 5 minutes ECG recordings in the supine and standing positions...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29037619/evidence-based-effects-of-yoga-practice-on-various-health-related-problems-of-elderly-people-a-review
#3
A Mooventhan, L Nivethitha
More than 50% of the elderly above 60 years of age suffer from chronic medical conditions, the prevalence of which increases with age. Though Yoga has been reported as an effective modality in improving various physical and psychological aspects of elderly populations, a comprehensive review of Yoga and its effects on various health related problems of elderly populations has not yet been reported. Hence, we performed PubMed/Medline search to review relevant articles, using keyword "yoga and elderly". Relevant articles published since inception till 6th October 2016 were included for the review...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29026411/healthy-eating-index-and-cardiovascular-risk-factors-among-iranian-elderly-individuals
#4
Nafiseh Rashidipour-Fard, Majid Karimi, Sahar Saraf-Bank, Mohammad Hassan Baghaei, Fahimeh Haghighatdoost, Leila Azadbakht
BACKGROUND: Concurrent with increase in life expectancy, the prevalence of chronic diseases such as cardiovascular diseases (CVD) has also increased. Therefore, the aim of this study was to evaluate the association between healthy eating index (HEI) score and CVD risk factors among Iranian elderly. METHODS: This cross-sectional study was performed on a sample of elderly persons from Isfahan, Iran, in 2013. Totally, 107 retired subjects were entered in statistical analysis...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28977924/antihyperglycemic-treatment-in-patients-with-type-2-diabetes-in-italy-the-impact-of-age-and-kidney-function
#5
Sandro Gentile, Pamela Piscitelli, Francesca Viazzi, Giuseppina Russo, Antonio Ceriello, Carlo Giorda, Piero Guida, Paola Fioretto, Roberto Pontremoli, Felice Strollo, Salvatore De Cosmo
We describe AHA utilization pattern according to age and renal function in type 2 diabetes mellitus (T2DM), in real-life conditions. The analysis was performed using the data set of electronic medical records collected between 1 January and 31 December, 2011 in 207 Italian diabetes centers. The study population consisted of 157,595 individuals with T2DM. The AHA treatment regimens was evaluated. Kidney function was assessed by eGFR, estimated using the CKD-EPI formula. Other determinations: HbA1c, blood pressure (BP), low- density lipoprotein (LDL-c), total and high density lipoprotein cholesterol (TC and HDL-c), triglycerides (TG) and serum uric acid (SUA)...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28974910/serum-leptin-level-positively-correlates-with-metabolic-syndrome-among-elderly-taiwanese
#6
Li-Hsuan Wang, Yao-Chang Liu, Ji-Hung Wang, Chung-Jen Lee, Bang-Gee Hsu
OBJECTIVE: Leptin is an adipocyte-derived hormone and has shown positive correlation with obesity and metabolic syndrome (MetS) in many studies. However, there are few studies investigating this relation in elderly people. Therefore, we aimed to investigate the correlation between the fasting serum leptin level and MetS among older Taiwanese. MATERIALS AND METHODS: The fasting serum leptin level was obtained from 62 Taiwanese participants over 65 years old and was measured using a commercially available enzyme immunoassay kit...
July 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28966225/a-case-report-of-fulminant-type-1-diabetes-mellitus-associated-with-drug-induced-hypersensitivity-syndrome-in-an-elderly-patient-with-coxsackie-b4-virus-infection-and-human-leukocyte-antigen-a24-haplotype
#7
Ayumu Takeno, Ippei Kanazawa, Miwa Morita, Kai Takedani, Hitomi Miyake, Masahiro Yamamoto, Kyoko Nogami, Sakae Kaneko, Toshitsugu Sugimoto
Drug-induced hypersensitivity syndrome (DIHS) is a severe systemic adverse drug reaction. Previous studies showed that DIHS is associated with the onset of fulminant type 1 diabetes mellitus (FT1D). Although genetic background and abnormalities in immune response or viral infection are considered to be associated with pathogenesis of FT1D, it remains unclear whether virus infection and specific human leukocyte antigen (HLA) typing are involved in DIHS-associated FT1D. Here, we report a case of a 78-year-old female patient with FT1D after DIHS treatment...
September 29, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28953643/body-mass-index-and-waist-circumference-are-better-predictors-of-insulin-resistance-than-total-body-fat-percentage-in-middle-aged-and-elderly-taiwanese
#8
Yiu-Hua Cheng, Yu-Chung Tsao, I-Shiang Tzeng, Hai-Hua Chuang, Wen-Cheng Li, Tao-Hsin Tung, Jau-Yuan Chen
The incidence of diabetes mellitus is rising worldwide, and prediabetic screening for insulin resistance (IR) has become ever more essential. This study aimed to investigate whether body mass index (BMI), waist circumference (WC), or body fat percentage (BF%) could be a better predictor of IR in a middle-aged and elderly population. In this cross-sectional, community-based study, 394 individuals (97 with IR and 297 without IR) were enrolled in the analysis. IR was measured by homeostasis model assessment (HOMA-IR), and subjects with HOMA-IR value ≧75th percentile were defined as being IR...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28949318/psychogeriatric-diagnoses-in-old-people-s-homes-and-negative-health-behavior
#9
Spomenka Tomek-Roksandić, Ivana Popek, Nada Tomasović Mrčela, Zvonimir Šostar, Branko Kolarić, Nina Smolej Narančić, Ana Stavljenić Rukavina, Mate Ljubičić
BACKGROUND: The study was designed as a gerontologic-public health analysis of the relationship between the leading and accompanying psychogeriatric diagnoses and negative health behaviors recorded in the old people's home users, with the aim to evaluate and redefine gerontologic-public health priorities and geroprophylactic measures, with special reference to persons suffering from Alzheimer's disease and other dementias. SUBJECT AND METHODS: Gerontologic-public health indicators obtained by monitoring health care needs of the elderly in specific institutional primary health care at 10 old people's homes (N=1185) in Croatia in 2013 were analyzed using the professional methodology developed at Department of Health Gerontology, Andrija Štampar Teaching Institute of Public Health (Registry List 1 that refers to monitoring specific primary health care needs of elderly at old people's homes)...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28943478/sexual-dimorphism-of-metabolic-and-vascular-dysfunction-in-aged-mice-and-those-lacking-the-sphingosine-1-phosphate-receptor-3
#10
Amanda T Cao, Martina Mackova, Daniel Kerage, David N Brindley, Denise G Hemmings
Elderly people often suffer adverse health because of inflammation associated with poor metabolism and cardiovascular dysfunction, but these conditions present differently in men and women. We performed experiments in aged male and female mice to understand this sexual dimorphism. We focused on sphingosine 1-phosphate (S1P) signaling, which has both protective and detrimental effects on vascular and metabolic function. We examined vascular function of mesenteric (resistance) arteries from aged male and female wild-type (WT) mice compared to littermate S1P receptor 3 (S1PR3) knockouts (KO)...
September 22, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28942038/the-enpp1-k121q-polymorphism-modulates-developing-of-bone-disorders-in-type-2-diabetes-a-cross-sectional-study
#11
Nahid Neamati, Seyed Reza Hosseini, Mahmood Hajiahmadi, Sohrab Halalkhor, Hajighorban Nooreddini, Haleh Akhavan Niaki, Bahare Korani, Hadi Parsian
BACKGROUND: Osteoporosis and osteopenia are common diseases in every population. Type 2 diabetes mellitus (T2DM) can lead to the development of various complications, such as bone disorders especially among elderly individuals. Studies suggested that ectonucleotide pyrophosphatase/phosphodiesterase1 (ENPP1) is contributed in insulin resistance and also the inhibition of bone mineralization. In this study, association of K121Q (rs1044498) polymorphism of the ENPP1 gene with T2DM and bone disorders is evaluated...
December 30, 2017: Gene
https://www.readbyqxmd.com/read/28939527/assessment-of-fructose-overload-in-the-metabolic-profile-and-oxidative-nitrosative-stress-in-the-kidney-of-senescent-female-rats
#12
Deborah Chianelli Costalonga Seraphim, Giovana Rita Punaro, Thamires de Oliveira Fernandes, Milton Ginoza, Guiomar Silva Lopes, Elisa Mieko Suemitsu Higa
The aging process is a complex phenomenon that leads the body to several changes, affecting its integrity and resulting in chronic pathologies, which compromises health and quality of life of elderly people. Animals supplemented with fructose have been used as an experimental model for induction of insulin resistance. The objective of this study was to evaluate the metabolic effects and the levels of oxidative/nitrosative stress in the kidney of senescent rats with a high fructose intake. The animals were allocated into 4 groups: young control (Y), aged control (A), young fructose (YF) and aged fructose (AF)...
September 20, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28935388/%C3%AE-cell-function-over-time-in-adolescents-with-new-type-2-diabetes-and-obese-adolescents-without-diabetes
#13
Deborah A Elder, Lindsey N Hornung, Jane C Khoury, David A D'Alessio
PURPOSE: The progression of β-cell function in newly diagnosed adolescents with type 2 diabetes mellitus (T2DM) is not well documented. We hypothesized that at the time of diagnosis with T2DM, adolescents would have impaired β-cell function as demonstrated by the disposition index (calculated as: insulin secretion adjusted for insulin sensitivity), and this would be followed by a rapid decline of function despite standard medical management. METHODS: Thirty-nine adolescents with recently diagnosed T2DM and 32 obese adolescent controls with normal glucose tolerance had acute insulin response to glucose, homeostatic model assessment of insulin resistance, and disposition index measured serially over 2 years...
September 18, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28925048/the-association-between-insulin-resistance-metabolic-variables-and-depressive-symptoms-in-mexican-american-elderly-a-population-based-study
#14
Breno S Diniz, Susan Fisher-Hoch, Joseph McCormick
OBJECTIVE: Depressive symptoms are common among older adults with obesity and diabetes. Nonetheless, the mechanisms for this association are not clear but may involve changes in the insulin cascade signaling. We aimed to investigate the association, and potential mediators, between obesity, insulin resistance, and depressive symptoms among older adults from a homogenous cohort of Mexican-Americans. METHODS: We included a total of 500 Mexican-American older adults assessed in the Cameron County Health Study...
September 18, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28918198/are-we-missing-hypoglycaemia-elderly-patients-with-insulin-treated-diabetes-present-to-primary-care-frequently-with-non-specific-symptoms-associated-with-hypoglycaemia
#15
Suzy V Hope, Phil J Taylor, Beverley M Shields, Andrew T Hattersley, Willie Hamilton
INTRODUCTION: We assessed if patients with known hypoglycaemia present on other occasions with non-specific symptoms associated with (but not diagnosed as) hypoglycaemia, potentially representing missed hypoglycaemia. METHODS: 335 primary care records (5/2/12-4/2/13) from patients aged >65 (79 on insulin, 85 on sulphonylureas, 121 on metformin only, 50 without diabetes) were assessed for hypoglycaemia episodes and consultations with non-specific symptoms, "hypo clues"...
September 11, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28916790/association-between-homa-ir-and-lung-function-in-korean-young-adults-based-on-the-korea-national-health-and-nutrition-examination-survey
#16
Young Bok Lee, Young Soo Kim, Dong-Hee Lee, Hee Yeon Kim, Jae-Im Lee, Hyo-Suk Ahn, Tae Seo Sohn, Tae-Kyu Lee, Jae Yen Song, Chang Dong Yeo, Mihee Hong, Kyungdo Han, Seong Cheol Jeong, Hiun Suk Chae
Metabolic syndrome, including obesity and insulin resistance, has been reported to lower lung function in elderly subjects with asthma or chronic obstructive lung disease. This study aimed to find the association between lung function and insulin resistance in Korean young adults. This study used data from the Korean National Health and Nutrition Examination Survey 2011-2013, which is a representative sample of the Korean population. A total of 1,922 young adults aged 19 to 40 were included in the analysis...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28904260/impaired-%C3%AE-cell-function-and-decreased-insulin-sensitivity-in-subjects-with-normal-oral-glucose-tolerance-but-isolated-high-glycosylated-hemoglobin
#17
Qi Fu, Min Sun, Zhixiao Wang, Wei He, Yu Duan, Tao Yang
The pathophysiology is distinct in various state of glucose metabolism abnormalities. As the defect of individuals with normal oral glucose tolerance (NGT) but isolated high glycosylated hemoglobin (HbA1c), i.e. iHH, was ambiguous, we aimed to investigate the insulin sensitivity and β-cell function of iHH. According to the ADA criteria of HbA1c cut-off point (5.7%), 3,517 subjects with NGT screened from a total of 7,855 middle-aged and elderly Chinese without known diabetes were divided into two groups, 1,877 subjects with HbA1c < 5...
September 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28901796/efficacy-and-safety-of-saxagliptin-in-combination-with-insulin-in-japanese-patients-with-type-2-diabetes-mellitus-a-16-week-double-blind-randomized-controlled-trial-with-a-36-week-open-label-extension
#18
Takashi Kadowaki, Satsuki Muto, Yoshiumi Ouchi, Ryutaro Shimazaki, Yutaka Seino
BACKGROUND: We examined the efficacy and safety of saxagliptin as an add-on to insulin in Japanese patients with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS: We randomized 240 patients with type 2 diabetes mellitus on insulin monotherapy to 5-mg saxagliptin or placebo as add-on therapy for a 16-week, double-blind period. All patients received 5-mg saxagliptin and insulin for an additional 36 weeks (open-label extension). Change in hemoglobin A1c (HbA1c) at Week 16 was the main endpoint...
October 12, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28899347/case-report-of-hyperglycemic-nonketotic-chorea-with-rapid-radiological-resolution
#19
H M M T B Herath, S P Pahalagamage, Sunethra Senanayake
BACKGROUND: Hemichorea is a rare manifestation of nonketotic hyperglycemia that usually affects elderly Asian women with poor glycemic control. Non-contrast computerized Tomography and T1- weighted Magnetic Resonance Imaging shows characteristic hyperintense basal ganglia lesions. CASE PRESENTATION: A Fifty-seven year old Sri Lankan female presented with a two-day history of right upper limb chorea. She had been diagnosed with diabetes mellitus one year ago, but was not on any treatment and did not have any micro vascular or macro vascular complications...
September 12, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28892731/a-new-integrated-care-pathway-for-ambulance-attended-severe-hypoglycaemia-in-the-east-of-england-the-eastern-academic-health-science-network-eahsn-model
#20
Michael Sampson, Marcus Bailey, John Clark, Mark L Evans, Rebekah Fong, Helen Hall, Clare Hambling, Martin Hadley-Brown, Nick Morrish, Helen Murphy, Gerry A Rayman, Karunakaran Vithian, Peter Winocour, Amanda Harries
AIMS: We developed a new clinical integrated pathway linking a regional Ambulance Trust with a severe hypoglycaemia (SH) prevention team. We present clinical data from the first 2000 emergency calls taken through this new clinical pathway in the East of England. METHODS: SH patients attended by Ambulance crew receive written information on SH avoidance, and are contacted for further education through a new regional SH prevention team. All patients are contacted unless they actively decline...
September 1, 2017: Diabetes Research and Clinical Practice
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