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https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#1
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28418191/evaluation-of-chinese-herbal-medicine-jinlida-in-type-2-diabetes-patients-based-on-stratification-results-of-subgroup-analysis-from-12-week-trial
#2
Jiaxing Tian, Fengmei Lian, Libo Yang, Xiaolin Tong
BACKGROUND: Previous study found that the Chinese Herbal Medicine Jinlida could significantly enhance the hypoglycemic action of metformin compared to metformin alone. However, the advantage of Jinlida has not been clarified yet. We aimed to compare the efficacy of Jinlida in patients with T2DM based on stratification. METHODS: Data were analyzed from a 12-week, randomized, placebo-controlled, double-blind, multicenter study of Jinlida. The efficacy evaluation included HbA1c, FPG and 2hPG levels stratified by baseline HbA1c, sex, age, BMI, and duration of DM diagnosis...
April 18, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28397367/continuous-glucose-monitoring-reveals-hypoglycemia-risk-in-elderly-patients-with-type-2-diabetes-mellitus
#3
Takahiro Ishikawa, Masaya Koshizaka, Yoshiro Maezawa, Minoru Takemoto, Yoshiharu Tokuyama, Toshihiro Saito, Koutaro Yokote
INTRODUCTION: The incidence of type 2 diabetes is higher in elderly patients, in whom this disease is associated with dementia, falling, stroke, and death. We utilized a continuous glucose monitoring (CGM) device to analyze the relationship between hypoglycemia and diabetes treatments to identify risk factors for hypoglycemia (defined as a blood glucose level <70 mg/dL). MATERIALS AND METHODS: We classified 170 patients aged ≥65 years with type 2 diabetes who were receiving steady-state medication (29 of whom were inpatients) into hypoglycemic and non-hypoglycemic groups, and compared their HbA1c levels, treatment types, continuous glucose monitoring data, and other parameters...
April 11, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28393573/persistence-with-rapid-acting-insulin-and-its-association-with-a1c-level-and-severe-hypoglycemia-among-elderly-patients-with-type-2-diabetes
#4
Usha Sambamoorthi, Rahul Garg, Arijita Deb, Tao Fan, Anders Boss
OBJECTIVE: To examine the persistence with rapid-acting insulin (RAI) and its association with clinical outcomes among elderly patients with type 2 diabetes (T2D). METHODS: This observational, retrospective cohort study analyzed RAI persistence and its association with change in A1C and risk of severe hypoglycemia among elderly (≥65 years) Medicare beneficiaries with T2D who added RAI to their basal insulin regimen. RESULTS: Among T2D patients with >1 RAI prescriptions (n = 3,927), only 21% were persistent...
April 10, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28389469/metabolic-syndrome-insulin-resistance-and-cognitive-dysfunction-does-your-metabolic-profile-affect-your-brain
#5
Jesper S Neergaard, Katrine Dragsbæk, Claus Christiansen, Henning B Nielsen, Susanne Brix, Morten A Karsdal, Kim Henriksen
Dementia and type 2 diabetes are both characterized by long prodromal phases challenging the study of potential risk factors and their temporal relation. The progressive relation between metabolic syndrome, insulin resistance, and dementia has recently been questioned, wherefore the aim of this study was to assess the potential association between these precursors of type 2 diabetes and cognitive dysfunction. Using data from the Prospective Epidemiological Risk Factor study (n=2,103), a prospective study of elderly women in Denmark, we found that impaired fasting plasma glucose was associated with 44% (9%-91%) larger probability of developing cognitive dysfunction...
April 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28385552/intranasal-insulin-decreases-circulating-cortisol-concentrations-during-early-sleep-in-elderly-humans
#6
Matthias Thienel, Ines Wilhelm, Christian Benedict, Jan Born, Manfred Hallschmid
Aging is associated with increases in hypothalamic-pituitary-adrenal (HPA) axis activity that can predispose to metabolic and cognitive impairments. We investigated in elderly and young subjects whether intranasal insulin administration to the human brain reduces early-sleep nadir concentrations of adrenocorticotropin and cortisol, that is, indicators of baseline HPA axis activity. In within-subject comparisons, intranasal insulin (160 IU) or placebo was administered to 14 elderly (mean age 70.0 years) and 30 young (23...
June 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28384333/relationship-between-sleep-parameters-insulin-resistance-and-age-adjusted-insulin-like-growth-factor-1-score-in-non-diabetic-older-patients
#7
Sarah Damanti, Olivier Bourron, Mohamed Doulazmi, Anne-Laure Mandengue Sosso, Vi-Huong Nguyen-Michel, Jean Mariani, Kiyoka Kinugawa
BACKGROUND: Sleep complaints are prevalent in older patients. Sleepiness, short or long sleep duration and obstructive sleep apnea (OSA) are associated with insulin resistance (IR). These parameters have not yet been considered together in the same study exploring the possible association between IR and sleep in older patients. IR is involved in cardiovascular and metabolic diseases, pathologies which are highly prevalent in older patients. Here we assess, in older non-diabetic patients with sleep complaints, the associations between IR and sleep parameters objectively recorded by polysomnography (PSG) rather than self-report...
2017: PloS One
https://www.readbyqxmd.com/read/28382782/fatty-acid-binding-protein-4-regulates-fatty-infiltration-after-rotator-cuff-tear-by-hypoxia-inducible-factor-1-in-mice
#8
Yong-Soo Lee, Ja-Yeon Kim, Kyung-Soo Oh, Seok Won Chung
BACKGROUND: Fatty infiltration in skeletal muscle is directly linked to loss of muscle strength and is associated with various adverse physical outcomes such as muscle atrophy, inflammation, insulin resistance, mobility impairments, and even mortality in the elderly. Aging, mechanical unloading, muscle injury, and hormonal imbalance are main causes of muscle fat accumulation, and the fat cells are derived from muscle stem cells via adipogenic differentiation. However, the pathogenesis and molecular mechanisms of fatty infiltration in muscles are still not fully defined...
April 5, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28382551/high-doses-of-vitamin-c-plus-e-reduce-strength-training-induced-improvements-in-areal-bone-mineral-density-in-elderly-men
#9
Astrid Kamilla Stunes, Unni Syversen, Sveinung Berntsen, Gøran Paulsen, Tonje H Stea, Ken J Hetlelid, Hilde Lohne-Seiler, Mats Peder Mosti, Thomas Bjørnsen, Truls Raastad, Glenn Haugeberg
PURPOSE: Resistance training is beneficial for maintaining bone mass. We aimed to investigate the skeletal effects of high doses of antioxidants [vitamin C + E (α-tocopherol)] supplementation during 12-week supervised strength training in healthy, elderly men METHODS: Design: double-blinded randomized placebo-controlled study. Participants followed a supervised, undulating periodic exercise program with weekly adjusted load: 3 sessions/week and 3-15 repetitions maximum (RM) sets/exercise...
April 5, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28373319/erratum-for-el-hajj-fuleihan-et-al-effect-of-vitamin-d-replacement-on-indexes-of-insulin-resistance-in-overweight-elderly-individuals-a-randomized-controlled-trial-am-j-clin-nutr-2016-104-315-23
#10
(no author information available yet)
No abstract text is available yet for this article.
April 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28372715/management-of-hyperglycemic-crises-diabetic-ketoacidosis-and-hyperglycemic-hyperosmolar-state
#11
REVIEW
Maya Fayfman, Francisco J Pasquel, Guillermo E Umpierrez
Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are the most serious and life-threatening hyperglycemic emergencies in diabetes. DKA is more common in young people with type 1 diabetes and HHS in adult and elderly patients with type 2 diabetes. Features of the 2 disorders with ketoacidosis and hyperosmolality may coexist. Both are characterized by insulinopenia and severe hyperglycemia. Early diagnosis and management are paramount. Treatment is aggressive rehydration, insulin therapy, electrolyte replacement, and treatment of underlying precipitating events...
May 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/28372558/fatty-acid-composition-in-serum-cholesterol-esters-and-phospholipids-is-linked-to-visceral-and-subcutaneous-adipose-tissue-content-in-elderly-individuals-a-cross-sectional-study
#12
Fredrik Rosqvist, Helena Bjermo, Joel Kullberg, Lars Johansson, Karl Michaëlsson, Håkan Ahlström, Lars Lind, Ulf Risérus
BACKGROUND: Visceral adipose tissue (VAT) and truncal fat predict cardiometabolic disease. Intervention trials suggest that saturated fatty acids (SFA), e.g. palmitic acid, promote abdominal and liver fat storage whereas polyunsaturated fatty acids (PUFA), e.g. linoleic acid, prevent fat accumulation. Such findings require investigation in population-based studies of older individuals. We aimed to investigate the relationships of serum biomarkers of PUFA intake as well as serum levels of palmitic acid, with abdominal and total adipose tissue content...
April 4, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28369870/antihyperglycemic-drugs-use-and-new-onset-atrial-fibrillation-in-elderly-patients
#13
Hung-Yi Chen, Fu-Yu Yang, Gwo-Ping Jong, Yi-Sheng Liou
BACKGROUND: Antihyperglycemic drugs have been linked to new-onset atrial fibrillation (NAF). However, the effect of the different classes of antihyperglycemic drugs on the development of NAF in elderly patients has not been well studied. In this study, we investigated the association between different classes of antihyperglycemic drugs and NAF in elderly patients. MATERIAL AND METHODS: This was a nested case-control study performed using the database of National Health Insurance Program in Taiwan...
March 30, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28366822/quality-specifications-for-the-extra-analytical-phase-of-laboratory-testing-reference-intervals-and-decision-limits
#14
REVIEW
Ferruccio Ceriotti
Reference intervals and decision limits are a critical part of the clinical laboratory report. The evaluation of their correct use represents a tool to verify the post analytical quality. Four elements are identified as indicators. 1. The use of decision limits for lipids and glycated hemoglobin. 2. The use, whenever possible, of common reference values. 3. The presence of gender-related reference intervals for at least the following common serum measurands (besides obviously the fertility relate hormones): alkaline phosphatase (ALP), alanine aminotransferase (ALT), creatine kinase (CK), creatinine, gamma-glutamyl transferase (GGT), IgM, ferritin, iron, transferrin, urate, red blood cells (RBC), hemoglobin (Hb) and hematocrit (Hct)...
March 30, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28351218/association-among-serum-igf-1-frailty-muscle-mass-bone-mineral-density-and-physical-performance-among-community-dwelling-middle-aged-and-older-adults-in-taiwan
#15
Liang-Yu Chen, Yi-Hui Wu, Li-Kuo Liu, Wei-Ju Lee, An-Chun Hwang, Li-Ning Peng, Ming-Hsien Lin, Liang-Kung Chen
BACKGROUND: Aging is featured by the complex interrelationship between among body composition, frailty status and physical performance. The main aim of this study was to evaluate the association between among serum insulin-like growth factor-1 (IGF-1), body composition, and physical function among community-dwelling middle-aged and elderly population in Taiwan. METHODS: We conducted a cross-sectional study by using the data of I-Lan Longitudinal Aging Study (ILAS), which recruited a total of 1,833 community-dwelling people aged 50 years and older...
March 29, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28338810/associations-of-proatrial-natriuretic-peptide-with-components-of-the-metabolic-syndrome-in-adolescents-and-young-adults-from-the-general-population
#16
Tina S Goharian, Jens P Goetze, Jens Faber, Lars B Andersen, Anders Grøntved, Jørgen L Jeppesen
BACKGROUND: In middle-aged and elderly populations, circulating natriuretic peptide concentrations are negatively associated with several components of the metabolic syndrome. Whether these negative associations are also present in healthy adolescents and young adults from the general population are unknown. METHODS: In a cross-sectional setting, we measured plasma concentrations of mid-regional proatrial natriuretic peptide (MR-proANP) in 343 adolescents (age 14-16 years) and 616 young adults (age 20-28 years) from the Danish site of the European Youth Heart Study, which is a population-based study of cardiovascular disease risk factors in children, adolescents and young adults...
February 23, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28332619/retinol-binding-protein-4-levels-and-non-alcoholic-fatty-liver-disease-a-community-based-cross-sectional-study
#17
Xuechen Chen, Tianran Shen, Qing Li, Xu Chen, Yanping Li, Dan Li, Gengdong Chen, Wenhua Ling, Yu-Ming Chen
Previous reports on the association between retinol binding protein 4 (RBP4) and nonalcoholic fatty liver disease (NAFLD) were controversial. This study aimed to investigate the association between the serum RBP4 levels and occurrence of NAFLD in Chinese population. In total, 2938 participants aged 40-75 years were involved in this community-based cross-sectional study. General information, lifestyle factors, serum levels of RBP4 and the presence of NAFLD were determined. Patients with NAFLD had significantly higher concentrations of RBP4 (37...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28326339/glucose-dependent-insulinotropic-polypeptide-gip-and-gip-receptor-gipr-genes-an-association-analysis-of-polymorphisms-and-bone-in-young-and-elderly-women
#18
Gaurav Garg, Fiona E McGuigan, Jitender Kumar, Holger Luthman, Valeriya Lyssenko, Kristina Akesson
INTRODUCTION: The gastro-intestinal hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion, with bone anabolic effects through GIP receptor (GIPR) in animal models. We explore its potential in humans by analyzing association between polymorphisms (SNPs) in the GIP and GIPR genes with bone phenotypes in young and elderly women. METHODS: Association between GIP (rs2291725) and GIPR (rs10423928) and BMD, bone mineral content (BMC), bone microarchitecture, fracture and body composition was analyzed in the OPRA (75y, n = 1044) and PEAK-25 (25y; n = 1061) cohorts and serum-GIP in OPRA...
June 2016: Bone Reports
https://www.readbyqxmd.com/read/28325798/management-of-inpatient-hyperglycemia-and-diabetes-in-older-adults
#19
Guillermo E Umpierrez, Francisco J Pasquel
Adults aged 65 years and older are the fastest growing segment of the U.S. population, and their number is expected to double to 89 million between 2010 and 2050. The prevalence of diabetes in hospitalized adults aged 65-75 years and over 80 years of age has been estimated to be 20% and 40%, respectively. Similar to general populations, the presence of hyperglycemia and diabetes in elderly patients is associated with increased risk of hospital complications, longer length of stay, and increased mortality compared with subjects with normoglycemia...
April 2017: Diabetes Care
https://www.readbyqxmd.com/read/28324596/blood-pressure-and-metabolic-changes-after-3-month-cpap-therapy-in-a-very-elderly-obese-with-severe-obstructive-sleep-apnea-a-case-report-and-review-of-the-literature
#20
Francesco Spannella, Federico Giulietti, Chiara Di Pentima, Francesca Elena Lombardi, Elisabetta Borioni, Riccardo Sarzani
Age is one of the main risk factor for the presence of obstructive sleep apnea (OSA). This syndrome is associated with hypertension, cardiovascular disease, cognitive impairment and metabolic abnormalities, such as type 2 diabetes. Continuous positive airway pressure (CPAP) represents the gold standard therapy, but its benefit is still to be determined in very elderly. We report the blood pressure and metabolic changes in a very elderly obese with severe OSA after 3-month CPAP therapy. We have evaluated a very elderly obese male affected by severe symptomatic OSA, poor controlled nocturnal hypertension and insulin resistance...
March 21, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
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