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Insulin / elderly

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https://www.readbyqxmd.com/read/27933679/supplementation-with-nutrients-modulating-insulin-like-growth-factor-1-negatively-correlated-with-changes-in-the-levels-of-pro-inflammatory-cytokines-in-community-dwelling-elderly-people-at-risk-of-undernutrition
#1
M Kim, M Kim, Y J Lee, H J Song, J K Shim, D H Chang, W K Yu, S-H Lee, J H Lee
BACKGROUND: Suboptimal nutrition accompanied by chronic low-grade increases in circulating cytokine levels is more common in elderly people. We explored the improvement in nutritional status, especially in the level of insulin-like growth factor-1 (IGF-1) and its relationship with changes in circulating cytokine levels, after providing extra protein and energy content to community-dwelling older adults at risk of undernutrition. METHODS: Sixty nondiabetic subjects, aged ≥65 years and living independently in a community for elderly people, with a serum pre-albumin level ≤30 mg dL(-1) and a body mass index <25 kg m(-2) , were recruited...
December 9, 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/27931122/modulation-of-pancreatic-islets-function-and-survival-during-aging-involves-the-differential-regulation-of-endoplasmic-reticulum-stress-by-p21-and-chop
#2
Chrysovalantou Mihailidou, Ioulia Chatzistamou, Athanasios Papavassiliou, Hippokratis Kiaris
AIMS: While endoplasmic reticulum (ER) stress is recognized as a major mechanism causing pancreatic dysfunction in diabetes, little is known on how aging modulates the process. Here we compared the response to ER stress, viability and insulin release from pancreatic islets of young (6 weeks) or aged (14 months) mice. RESULTS: Islets from aged mice were more sensitive to ER stress than their younger counterparts, they exhibited more pronounced unfolded protein response (UPR) and caspase activation and displayed compromised insulin release after high glucose stimulation...
December 8, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27921419/-metabolic-syndrome-in-patients-with-diabetes-mellitus-type-1-prevalence-impact-on-morbidity-and-mortality
#3
Jitka Brožová, Daniela Čechurová, Silvie Lacigová
: Aim of this retrospective observational study was to determine the prevalence of metabolic syndrome (MS) in patients with diabetes mellitus type 1 (DM1Z) at baseline (in 2003) and find the parameters that determine the difference between group with (MS+) and without MS (MS-). Did the presence of MS affect morbidity and mortality in the subsequent 10 years? METHODS: 278 patients were enrolled to the study with age average 39 ± 13 years with medical history of diabetes 15...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27918964/sarcopenia-in-older-mice-is-characterized-by-a-decreased-anabolic-response-to-a-protein-meal
#4
Miriam van Dijk, Jolanda Nagel, Francina J Dijk, Jerôme Salles, Sjors Verlaan, Stephane Walrand, Klaske van Norren, Yvette Luiking
Ageing is associated with sarcopenia, a progressive decline of skeletal muscle mass, muscle quality and muscle function. Reduced sensitivity of older muscles to respond to anabolic stimuli, i.e. anabolic resistance, is part of the underlying mechanisms. Although, muscle parameters have been studied in mice of various ages/strains; the aim was to study if mice display similar deteriorating processes as human ageing. Therefore, 10,16,21 and 25 months-old C57BL6/6J male mice were studied to measure parameters of sarcopenia and factors contributing to its pathophysiology, with the aim of characterizing sarcopenia in old mice...
November 27, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27885860/pioglitazone-for-the-treatment-of-alzheimer-s-disease
#5
Daniela Galimberti, Elio Scarpini
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Pharmacological treatment of AD includes Anticholinesterase Inhibitors (AChEIs) for mild-moderate AD, and memantine for severe AD. These drugs provide mainly symptomatic short-term benefits without clearly influencing the progression of the disease. Pioglitazone (AD4833) is an insulin sensitizer of the thiazolidinedione class of nuclear Peroxisome-Proliferator Activated Receptor γ (PPARγ) agonists. It binds to PPARγ, affecting gene transcription and reducing inflammation...
November 25, 2016: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/27882107/effects-of-sitagliptin-as-initial-therapy-in-newly-diagnosed-elderly-type-2-diabetics-a-randomized-controlled-study
#6
Xiaoyan Xiao, Xiaopei Cui, Jianbo Zhang, Zhenxia Han, Yu Xiao, Nan Chen, Baoying Li, Mei Cheng, Haiqing Gao, Kuanxiao Tang
The objective of this study was to investigate the characteristics of blood glycemic excursion, incretins and pancreatic hormone secretion in elderly people with newly diagnosed type 2 diabetes mellitus (T2DM) and to study the effects of sitagliptin on glycemic excursion in these subjects. A total of 129 newly diagnosed T2DM patients were enrolled in the study from March 2012 to August 2013. Clinical data, serum incretin, pancreatic hormone and continuous glucose monitoring data were collected. Among these subjects, elderly patients (NEDM) randomly received metformin combined with sitagliptin phosphate or glimepiride for 24 weeks...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27873152/a-comparison-of-pharmacokinetic-and-pharmacodynamic-properties-between-faster-acting-insulin-aspart-and-insulin-aspart-in-elderly-subjects-with-type-1-diabetes-mellitus
#7
Tim Heise, Ulrike Hövelmann, Eric Zijlstra, Kirstine Stender-Petersen, Jacob Bonde Jacobsen, Hanne Haahr
BACKGROUND: Due to population aging, an increasing number of elderly patients with diabetes use insulin. It is therefore important to investigate the characteristics of new insulins in this population. Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with faster absorption. This study investigated the pharmacological properties of faster aspart in elderly subjects with type 1 diabetes mellitus (T1DM). METHODS: In a randomised, double-blind, two-period crossover trial, 30 elderly (≥65 years) and 37 younger adults (18-35 years) with T1DM received single subcutaneous faster aspart or IAsp dosing (0...
November 21, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27845200/a-combination-of-korean-mistletoe-extract-and-resistance-exercise-retarded-the-decline-in-muscle-mass-and-strength-in-the-elderly-a-randomized-controlled-trial
#8
Nam Ju Lim, Jun Ho Shin, Hye Jin Kim, Yeni Lim, Ji Yeon Kim, Won Jun Lee, Soo Jeong Han, Oran Kwon
Given the increased concerns about the degenerative decline in the physical performance of the elderly, there is a need for developing effective strategies to suppress the age-related loss of skeletal muscle mass and functional capacity through a lifestyle intervention. This randomized controlled trial examined whether a combination of Korean mistletoe extract (KME) supplement and exercise affected muscle mass, muscle function, and targeted molecular expressions. Sixty-seven subjects aged 55-75years were assigned to placebo, low-dose (1g/d), or high-dose (2g/d) of KME for 12weeks...
November 11, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27843832/evaluation-of-quality-of-life-and-depression-levels-in-individuals-with-type-2-diabetes
#9
Ali Altınok, Kamile Marakoğlu, Nisa Çetin Kargın
INTRODUCTION: Improving the quality of life in diabetic individuals is known to reduce morbidity and mortality. We aimed to investigate the quality of life and depression symptomatology situations and the related factors in patients with Type 2 diabetes mellitus (DM) in this study. MATERIALS AND METHODS: In this study, 440 adult patients with Type 2 DM and under treatment admitted to Selcuk University Family Medicine Outpatient Diabetes Education Clinic were included in the study...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27837286/is-there-evidence-of-potential-overtreatment-of-glycaemia-in-elderly-people-with-type-2-diabetes-data-from-the-guidance-study
#10
Nicolle Müller, Kamlesh Khunti, Oliver Kuss, Ulf Lindblad, John J Nolan, Guy Ehm Rutten, Marina Trento, Massimo Porta, Johannes Roth, Guillaume Charpentier, Viktor Jörgens, Ulrich A Müller
AIMS: We used data from the GUIDANCE Study to determine the care of people with type 2 diabetes according to age and accompanying cardiovascular diseases and to assess indicators of overtreatment of glycaemia. METHODS: The GUIDANCE study was a retrospective, cross-sectional study from 2009-2010 based on the records of 7597 people in France, Belgium, Italy, the Netherlands, Sweden, UK, Ireland and Germany. We analysed the level of metabolic control achieved and blood glucose-lowering medication used in different age groups and in relation to accompanying diseases...
November 11, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27830836/long-term-lifestyle-interventions-in-middle-aged-and-elderly-men-with-nonalcoholic-fatty-liver-disease-a-randomized-controlled-trial
#11
Fangyuan Dong, Yan Zhang, Yiqin Huang, Yiqian Wang, Gansheng Zhang, Xiaona Hu, Jiaofeng Wang, Jie Chen, Zhijun Bao
Nonalcoholic fatty liver disease (NAFLD), a metabolic disorder related to insulin resistance and metabolic syndrome, has become a public health concern. Currently, the principal therapeutic modalities targeting NAFLD are lifestyle interventions. However, the efficacy of long-term lifestyle interventions in managing NAFLD remains largely unexplored. This study aimed to evaluate the efficacy of long-term lifestyle interventions in middle-aged and elderly men with NAFLD. All 280 eligible patients were randomized to the control or test group...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822422/association-of-insulin-resistance-with-breast-ovarian-endometrial-and-cervical-cancers-in-non-diabetic-women
#12
Wanwan Sun, Jieli Lu, Shengli Wu, Yufang Bi, Yiming Mu, Jiajun Zhao, Chao Liu, Lulu Chen, Lixin Shi, Qiang Li, Tao Yang, Li Yan, Qin Wan, Yan Liu, Guixia Wang, Zuojie Luo, Xulei Tang, Gang Chen, Yanan Huo, Zhengnan Gao, Qing Su, Zhen Ye, Youmin Wang, Guijun Qin, Huacong Deng, Xuefeng Yu, Feixia Shen, Li Chen, Liebin Zhao, Tiange Wang, Jichao Sun, Min Xu, Yu Xu, Yuhong Chen, Meng Dai, Jie Zhang, Di Zhang, Shenghan Lai, Donghui Li, Guang Ning, Weiqing Wang
Hyperinsulinemia and insulin resistance were reported to play a crucial role in diabetes-cancer relationship. This study aimed to explore the associations between insulin resistance and several female cancers in a non-diabetic population. This cross-sectional study was conducted in 121,230 middle-aged and elderly non-diabetic women. Cancer diagnosis was self-reported and further validated by medical records. Insulin resistance was defined as homeostasis model assessment of insulin resistance (HOMA-IR) ≥ 2...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27822025/deep-analyses-of-the-associations-of-a-series-of-biomarkers-with-insulin-resistance-metabolic-syndrome-and-diabetes-risk-in-nondiabetic-middle-aged-and-elderly-individuals-results-from-a-chinese-community-based-study
#13
Shihui Fu, Ping Ping, Leiming Luo, Ping Ye
OBJECTIVE: The current study was designed to perform deep analyses of the associations of biomarkers, including high-sensitivity C-reactive protein (hs-CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and homocysteine (Hcy), with insulin resistance (IR), metabolic syndrome (MetS), and diabetes risk and evaluate the abilities of biomarkers to identify IR, MetS, and diabetes risk in Chinese community-dwelling middle-aged and elderly residents. PARTICIPANTS AND METHODS: A total of 396 participants older than 45 years underwent physical examinations and laboratory analyses following standardized protocol...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27812983/ampk-as-a-pro-longevity-target
#14
Kristopher Burkewitz, Heather J M Weir, William B Mair
Chronic, age-associated diseases are already among the leading causes of morbidity and death in the world, a problem exacerbated by the rapidly rising proportion of elderly in the global population. This emergent epidemic represents the next great challenge for biomedical science and public health. Fortunately, decades of studies into the biology of aging have provided a head start by revealing an evolutionarily conserved network of genes that controls the rate and quality of the aging process itself and which can thereby be targeted for protection against age-onset disease...
2016: EXS
https://www.readbyqxmd.com/read/27810270/the-association-between-insulin-resistance-and-depression-in-the-korean-general-population
#15
Jae-Hon Lee, Sung Keun Park, Jae-Hong Ryoo, Chang-Mo Oh, Rodrigo B Mansur, Jeffrey E Alfonsi, Danielle S Cha, Yena Lee, Roger S McIntyre, Ju Young Jung
BACKGROUND: Previous studies showed that the insulin resistance (IR) could be related to depression. However, this association is still equivocal in the general population. Herein, we aimed to investigate the association between IR and depressive symptoms in a large sample in South Korea. METHODS: A cross-sectional study was carried out for 165,443 Korean men and women who received a health checkup including various clinical parameters and the Center for Epidemiologic Studies Depression scales (CES-D)...
October 24, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27805269/inactivity-and-its-associated-factors-in-adults-scheduled-for-noncardiac-surgery-the-pamp-phase-i-study
#16
Olga L Cortés, Karen Moreno, Paula Alvarado, Camilo Povea, Monique Lloyd, Rodolfo Dennis
PURPOSE: The aim of this study was to determine the prevalence of physical inactivity and its associated factors in adult patients admitted to hospital for noncardiac surgery. DESIGN: Cross-sectional study. METHODS: Five hundred able-bodied patients (age ≥45 years) admitted to hospital, also participants in the VISION study, were recruited before noncardiac surgery. The physical activity level (PAL) was assessed with the International Physical of Activity Questionnaire...
November 2, 2016: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/27789974/nationwide-trends-in-glucose-lowering-drug-use-denmark-1999-2014
#17
Diana Hedevang Christensen, Jørgen Rungby, Reimar Wernich Thomsen
PURPOSE: The objective of this study was to examine nationwide population-based time trends in the utilization of all glucose-lowering drugs in Denmark from 1999 to 2014. METHODS: Based on nationwide data from the Register of Medicinal Products Statistics, we retrieved sales statistics on glucose-lowering drugs and reported the total number of users and the prevalence of users per 1,000 inhabitants in 1-year intervals for all glucose-lowering drug classes. RESULTS: The annual prevalence of glucose-lowering drug users increased more than twofold from 19 per 1,000 inhabitants in 1999 (n=98,362) to 41 per 1,000 in 2014 (n=233,230)...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27780977/weight-loss-surgery-in-adolescents-corrects-high-density-lipoprotein-subspecies-and-their-function
#18
W S Davidson, T H Inge, H Sexmith, A Heink, D Elder, D Y Hui, J T Melchior, T Kelesidis, A S Shah
BACKGROUND/OBJECTIVE: Youth with obesity have an altered high-density lipoprotein (HDL) subspecies profile characterized by depletion of large apoE-rich HDL particles and an enrichment of small HDL particles. The goal of this study was to test the hypothesis that this atherogenic HDL profile is reversible and that HDL function would improve with metabolic surgery. METHODS: Serum samples from adolescent males with severe obesity mean±s.d. age of 17.4±1.6 years were studied at baseline and 1 year following vertical sleeve gastrectomy (VSG)...
November 22, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27776987/endocrinology-of-aging-from-a-muscle-function-point-of-view-results-from-the-toledo-study-for-healthy-aging
#19
Amelia Guadalupe-Grau, Jose Antonio Carnicero, Jose Losa-Reyna, Jesús Tresguerres, Maria Del Carmen Gómez-Cabrera, Carmen Castillo, Ana Alfaro-Acha, Cristina Rosado-Artalejo, Leocadio Rodriguez-Mañas, Francisco José García-García
INTRODUCTION: Aging is a process that involves a reduction in muscle strength and anabolic hormone concentrations, which impacts significantly on health. AIM: To study the hormone/total strength (H/TS) ratio as a proxy of anabolic insensitivity status in elders, and its relationship with disability, hospitalization, and mortality risk. DESIGN: A total of 1462 persons aged ≥65 years from the Toledo Study of Healthy Aging participated in this study...
October 21, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27771738/serum-dehydroepiandrosterone-levels-are-associated-with-lower-risk-of-type-2-diabetes-the-rotterdam-study
#20
Adela Brahimaj, Taulant Muka, Maryam Kavousi, Joop S E Laven, Abbas Dehghan, Oscar H Franco
AIMS/HYPOTHESIS: Previous literature documents controversial results for the impact of dehydroepiandrosterone (DHEA) in glucose metabolism. We aimed to assess the associations between serum levels of DHEA and its main derivatives DHEA sulphate (DHEAS) and androstenedione, as well as the ratio of DHEAS to DHEA, and risk of type 2 diabetes. METHODS: We used data on serum levels of DHEA, DHEAS and androstenedione from 5189 middle-aged and elderly men and women from the prospective population-based Rotterdam Study...
January 2017: Diabetologia
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