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https://www.readbyqxmd.com/read/29436564/the-effects-of-celery-leaf-apium-graveolens-l-treatment-on-blood-glucose-and-insulin-levels-in-elderly-pre-diabetics
#1
Yusni Yusni, Hendra Zufry, Firdalena Meutia, Krishna W Sucipto
To analyze the effect of celery leaf extract on blood glucose and plasma insulin levels in elderly pre-diabetics. Methods: This study was conducted between March and November 2014 at the Faculty of Medicine, Syiah Kuala University, Banda Aceh, Indonesia. A quasi-experimental pretest-posttest with a control group was conducted with elderly pre-diabetic volunteers. The subjects included 16 elderly pre-diabetics older than 60 (6 males and 10 females). The subjects were randomly divided into 2 groups: a control group (placebo-treated) and a treatment group (celery-treated)...
February 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29427177/trends-in-diabetes-treatment-and-monitoring-among-medicare-beneficiaries
#2
Bruce E Landon, Alan M Zaslavsky, Jeffrey Souza, John Z Ayanian
BACKGROUND: Diabetes is a costly and common condition, but little is known about recent trends in diabetes management among Medicare beneficiaries. OBJECTIVE: To evaluate the use of diabetes medications and testing supplies among Medicare beneficiaries. DESIGN/SETTING: Retrospective cohort analysis of Medicare claims from 2007 to 2014. PARTICIPANTS: Traditional Medicare beneficiaries with a diagnosis of diabetes in the current or any prior year...
February 9, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29421825/insulin-leptin-axis-cardiometabolic-risk-and-oxidative-stress-in-elderly-with-metabolic-syndrome
#3
Daniela Gradinaru, Husseina Khaddour, Denisa Margina, Anca Ungurianu, Claudia Borsa, Cristina Ionescu, Gabriel-Ioan Prada, Joshua Usher, Yahya Elshimali
Insulin and leptin have an overlapping anorexigenic action as well as opposite effects on glucose and lipid metabolism. The study focuses on the biochemical and clinical relevance of new indices of insulin-leptin axis utilized in the study of the relationships between leptinemia, insulin sensitivity and oxidative stress, in elderly subjects with metabolic syndrome. We conducted clinical studies on elderly people with metabolic syndrome versus control subjects by creating new insulin-adipogenic indices, namely Insulin-to-Leptin Ratio (ILR) and Insulin-Adipogenic Resistance index (IAR-index)...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29412438/the-vicious-cycle-of-myostatin-signaling-in-sarcopenic-obesity-myostatin-role-in-skeletal-muscle-growth-insulin-signaling-and-implications-for-clinical-trials
#4
L A Consitt, B C Clark
The age-related loss of skeletal muscle (sarcopenia) is a major health concern as it is associated with physical disability, metabolic impairments, and increased mortality. The coexistence of sarcopenia with obesity, termed 'sarcopenic obesity', contributes to skeletal muscle insulin resistance and the development of type 2 diabetes, a disease prevalent with advancing age. Despite this knowledge, the mechanisms contributing to sarcopenic obesity remain poorly understood, preventing the development of targeted therapeutics...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29411486/severe-insulin-resistance-in-disguise-a-familial-case-of-reactive-hypoglycemia-associated-with-a-novel-heterozygous-insr-mutation
#5
Stefania Innaurato, Gemma V Brierley, Valeria Grasso, Arianna Massimi, Rossella Gaudino, Sara Sileno, Sergio Bernardini, Robert Semple, Fabrizio Barbetti
AIM: Hypoglycemia in childhood is very rare and can be caused by genetic mutations or insulin-secreting neoplasms. Postprandial hypoglycemia has previously been associated with insulin receptor (INSR) gene mutations. We aimed to identify the cause of postprandial hypoglycemia in a 10-year-old boy. SUBJECTS: We studied the symptomatic proband and his apparently asymptomatic mother and elder brother. All of them were lean. METHODS: Metabolic screening of the proband included a 5-hour oral glucose tolerance test (OGTT), angio-magnetic resonance imaging, and 18 F-dihydroxyphenylalanine positron emission tomography/computed tomography imaging of the pancreas...
February 7, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29394888/diabetic-kidney-disease-in-the-elderly-prevalence-and-clinical-correlates
#6
Giuseppina T Russo, Salvatore De Cosmo, Francesca Viazzi, Antonio Mirijello, Antonio Ceriello, Pietro Guida, Carlo Giorda, Domenico Cucinotta, Roberto Pontremoli, Paola Fioretto
BACKGROUND: Diabetic kidney disease (DKD) is a major burden in elderly patients with type 2 diabetes (T2DM). Low estimated glomerular filtration rate (eGFR+, < 60 mL/min/1.73 m2) and albuminuria (Alb+) are essential for the diagnosis of DKD, but their association with clinical variables and quality of care may be influenced by ageing. METHODS: Here we investigated the association of clinical variables and quality of care measures with eGFR+ and Alb+ in 157,595 T2DM individuals participating to the Italian Association of Clinical Diabetologists (AMD) Annals Initiative, stratified by age...
February 2, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29386421/clinical-characteristics-of-nonobese-patients-with-acute-coronary-syndrome-and-increased-epicardial-fat-volume
#7
Ken Harada, Hitomi Suzuki, Shun Matsunaga, Tomohiro Onishi, Yoshinori Nishikawa, Hiroshi Funakubo, Kumiko Mamiya, Tomoyuki Nagao, Norihiro Shinoda, Shinichi Sakai, Masataka Kato, Nobuyuki Marui, Hideki Ishii, Tetsuya Amano, Tatsuaki Matsubara, Toyoaki Murohara
AIM: Increased epicardial fat volume (EFV) is an independent risk factor for acute coronary syndrome (ACS). Although EFV increases with body mass index (BMI), some ACS patients have an increased EFV but normal BMI. We here investigated the clinical characteristics of nonobese ACS patients with an increased EFV. METHODS: A total of 197 Japanese patients hospitalized for ACS was evaluated for EFV, abdominal visceral fat area (VFA), and lipid and glucose profiles. Control subjects comprised 141 individuals who were suspected of having ACS but whose coronary computed tomography findings were normal...
February 1, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29383334/effects-of-toremifene-a-selective-estrogen-receptor-modulator-on-spontaneous-and-stimulated-gh-secretion-igf-i-and-igf-binding-proteins-in-healthy-elderly-subjects
#8
Ferdinand Roelfsema, Rebecca J Yang, Paul Y Takahashi, Dana Erickson, Cyril Y Bowers, Johannes D Veldhuis
Context: Estrogens amplify spontaneous and stimulated growth hormone (GH) secretion, whereas they diminish GH-dependent insulin-like growth factor (IGF)-I in a dose-dependent manner. Selective estrogen receptor modulators (SERMs), including tamoxifen and toremifene, are widely adjunctively used in breast and prostate cancer. Although some endocrine effects of tamoxifen are known, few data are available for toremifene. Objective: To explore sex-dependent effects of toremifene on spontaneous 10-hour overnight GH secretion, followed by GH-releasing hormone-ghrelin stimulation...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29382678/fatty-liver-index-albuminuria-and-the-association-with-chronic-kidney-disease-a-population-based-study-in-china
#9
Kan Sun, Diaozhu Lin, Feng Li, Yiqin Qi, Wanting Feng, Li Yan, Chaogang Chen, Meng Ren, Dan Liu
OBJECTIVES: The effects of lipid metabolism disorder on renal damage have drawn much attention. Using the fatty liver index (FLI) as a validated indicator of hepatic steatosis, this study aims to provide insight about the possible links between fatty liver and the development of chronic kidney disease (CKD). SETTING: Hospital. PARTICIPANTS: We performed a population-based study on 9436 subjects aged 40 years or older. PRIMARY AND SECONDARY OUTCOME MEASURES: FLI is calculated using an algorithm based on body mass index, waist circumference, triglycerides and γ-glutamyltransferase...
January 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29367900/epidemiological-analysis-of-patients-with-dupuytren-s-disease
#10
Henrique Gonçalves Mansur, Edmo Rodrigues de Oliveira, Cesar Barbosa Gonçalves
Objective: To evaluate the risk factors and analyze the characteristics of patients and lesions in Dupuytren's disease. Methods: Retrospective analysis of patients diagnosed with Dupuytren's disease in a hand surgery clinic in 2013. The authors evaluated parameters associated with the patient profiles and risk factors, the form and severity of involvement, and characteristics of the lesions. Results: 58 patients were evaluated, totaling 79 hands, with bilateral involvement in 46% of cases...
January 2018: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29361342/trajectories-of-bmi-change-impact-glucose-and-insulin-metabolism
#11
E I Walsh, J Shaw, N Cherbuin
BACKGROUND AND AIMS: The aim of this study was to examine, in a community setting, whether trajectory of weight change over twelve years is associated with glucose and insulin metabolism at twelve years. METHODS AND RESULTS: Participants were 532 community-living middle-aged and elderly adults from the Personality and Total Health (PATH) Through Life study. They spanned the full weight range (underweight/normal/overweight/obese). Latent class analysis and multivariate generalised linear models were used to investigate the association of Body Mass Index (BMI, kg/m2) trajectory over twelve years with plasma insulin (μlU/ml), plasma glucose (mmol/L), and HOMA2 insulin resistance and beta cell function at follow-up...
December 15, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29360778/effects-of-substitution-and-adding-of-carbohydrate-and-fat-to-whey-protein-on-energy-intake-appetite-gastric-emptying-glucose-insulin-ghrelin-cck-and-glp-1-in-healthy-older-men-a-randomized-controlled-trial
#12
Caroline Giezenaar, Yonta van der Burgh, Kylie Lange, Seva Hatzinikolas, Trygve Hausken, Karen L Jones, Michael Horowitz, Ian Chapman, Stijn Soenen
Protein-rich supplements are used widely for the management of malnutrition in the elderly. We reported previously that the suppression of energy intake by whey protein is less in older than younger adults. The aim was to determine the effects of substitution, and adding of carbohydrate and fat to whey protein, on ad libitum energy intake from a buffet meal (180-210 min), gastric emptying (3D-ultrasonography), plasma gut hormone concentrations (0-180 min) and appetite (visual analogue scales), in healthy older men...
January 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29356912/current-status-and-issues-of-the-artificial-pancreas-abridged-english-translation-of-a-special-issue-in-japanese
#13
REVIEW
Tsutomu Namikawa, Masaya Munekage, Tomoaki Yatabe, Hiroyuki Kitagawa, Kazuhiro Hanazaki
Surgical stress induces hyperglycemia and gives rise to glucose toxicity, which causes infectious diseases, resulting in unfavorable surgical outcomes. Intensive insulin treatment can control short- and long-term complications in patients with not only diabetes mellitus, but also surgical diabetes; however, it is associated with an increased risk of hypoglycemia. The wearable artificial pancreas was originally developed to control glucose levels in patients with type 1 diabetes, progressing to a device with enhanced stability and safety for these patients...
January 22, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29337071/lower-protein-and-higher-carbohydrate-intake-are-related-with-altering-metabolic-syndrome-components-in-elderly-women-a-cross-sectional-study
#14
Hellen C G Nabuco, Crisieli M Tomeleri, Paulo Sugihara Junior, Rodrigo Dos Reis Fernandes, Edilaine F Cavalcante, Melissa Antunes, Roberto Carlos Burini, Danielle Venturini, Décio S Barbosa, Analiza Mônica Silva, Edilson S Cyrino
BACKGROUND: Metabolic Syndrome (MetS) is an energy-disturbance disease associated with insulin resistance. Hence, the intake of energy-rich macronutrients might affect some MetS components. The aim of this study was to explore the association of ingested macronutrients with MetS components in older women. METHODS: A cross sectional study was conducted in 245 older women (≥60 years). Whole-body dual-energy X-ray absorptiometry was used to assess total body fat, percentage body fat (absolute and relative), and skeletal muscle mass...
March 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29324650/update-on-the-impact-of-omega-3-fatty-acids-on-inflammation-insulin-resistance-and-sarcopenia-a-review
#15
REVIEW
Alex Buoite Stella, Gianluca Gortan Cappellari, Rocco Barazzoni, Michela Zanetti
Elderly and patients affected by chronic diseases face a high risk of muscle loss and impaired physical function. Omega 3 fatty acids (FA) attenuate inflammation and age-associated muscle loss, prevent systemic insulin resistance and improve plasma lipids, potentially impacting on sarcopenia. This paper aims to review recent randomized clinical studies assessing the effects a chronic omega 3 FA supplementation on inflammatory and metabolic profile during conditions characterized by sarcopenia (aging, insulin resistance, type 2 diabetes, chronic renal failure)...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29313754/adipoq-45t%C3%A2-g-polymorphism-food-ingestion-and-metabolic-syndrome-in-elderly-persons
#16
Vanessa R Retamoso, Patrícia Maurer, Lyana B Feijóo, Graziela M S Tavares, Vanusa Manfredini, Jacqueline C E Piccoli
INTRODUCTION: The current nutritional transition process contributes further to accelerate the onset of metabolic disorders, as do a number of environmental factors that lead to the diagnosis of chronic diseases, as a diet of low nutritional value, is possibly related to the incidence of metabolic syndrome. In addition to these factors, metabolic syndrome may also be related to genetic factors, the ADIPOQ + 45T> G polymorphism has been associated with serum adiponectin levels, insulin sensitivity, and obesity, which affects adiponectin levels act as protective factor for cardiovascular disease...
January 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29301043/seasonality-of-insulin-resistance-glucose-and-insulin-among-middle-aged-and-elderly-population-the-rotterdam-study
#17
Magda Cepeda, Taulant Muka, M Arfan Ikram, Oscar H Franco, Josje D Schoufour
Context: There are discrepancies in the seasonality of insulin resistance (IR) across the literature, probably due to age-related differences in the seasonality of lifestyle factors and thermoregulation mechanisms. Objective: To estimate the seasonality of IR according to the homeostatic model assessment-insulin resistance (HOMA-IR), glucose, and insulin levels; and to examine the role of lifestyle markers (body mass index (BMI) and physical activity) and meteorological factors, according to age...
December 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29279487/changes-in-antidiabetic-drug-prescription-and-glycemic-control-trends-in-elderly-patients-with-type-2-diabetes-mellitus-from-2005-2013-an-analysis-of-the-national-center-diabetes-database-ncdd-03
#18
Ritsuko Yamamoto-Honda, Yoshihiko Takahashi, Yasumichi Mori, Shigeo Yamashita, Yoko Yoshida, Shoji Kawazu, Yasuhiko Iwamoto, Hiroshi Kajio, Hidekatsu Yanai, Shuichi Mishima, Nobuhiro Handa, Kotaro Shimokawa, Akiko Yoshida, Hiroki Watanabe, Kazuhiko Ohe, Takuro Shimbo, Mitsuhiko Noda
Objective To analyze the changes in the pharmacotherapy and glycemic control trends in elderly patients with type 2 diabetes mellitus (T2DM) in Japan. Materials and Methods We extracted the data of 7,590 patients (5,396 men and 2,194 women; median year of birth: 1945) with T2DM registered in the National Center Diabetes Database for the years 2005 to 2013, and conducted age-stratified (<65, 65-74, and ≥75 years of age) analyses. Results The hemoglobin A1c (HbA1c) levels declined from 2005 to 2013, and for those who received antihyperglycemic drug prescription, the HbA1c levels were lower in the older age group than in the younger age group...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29279430/-sarcopenia-and-metabolism
#19
Sumito Ogawa
Sarcopenia has been defined as an age-related loss of skeletal muscle mass, strength and function, and its diagnostic criteria is based on usual gait speed, grip strength, and skeletal muscle mass. Whereas underlying pathophysiology and mechanisms of sarcopenia still remains to be established, recent studies have suggested that sarcopenia is a risk factor for metabolic disorders, showing an association with insulin resistance, diabetes, and metabolic syndrome in elderly people.
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29279422/-aging-related-changes-in-motor-organs-and-energy-metabolism
#20
Mitsutaka Yakabe, Masahiro Akishita
Aging causes loss of skeletal muscle mass and strength, which is termed as sarcopenia. Aging of the neurological system may affect motor organs. Reduced muscle mass and increased fat mass induce insulin resistance, which is one of the causes for impaired glucose tolerance in the elderly.
2018: Clinical Calcium
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