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Insulin / elderly

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https://www.readbyqxmd.com/read/28228715/central-nervous-insulin-administration-before-nocturnal-sleep-decreases-breakfast-intake-in-healthy-young-and-elderly-subjects
#1
João C P Santiago, Manfred Hallschmid
Peripheral insulin acts on the brain to regulate metabolic functions, in particular decreasing food intake and body weight. This concept has been supported by studies in humans relying on the intranasal route of administration, a method that permits the direct permeation of insulin into the CNS without substantial absorption into the blood stream. We investigated if intranasal insulin administration before nocturnal sleep, a period of reduced metabolic activity and largely absent external stimulation, affects food intake and energy turnover on the subsequent morning...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28225792/the-adamts9-gene-is-associated-with-cognitive-aging-in-the-elderly-in-a-taiwanese-population
#2
Eugene Lin, Shih-Jen Tsai, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao, Cheng-Hung Yang
Evidence indicates that the pathophysiologic mechanisms associated with insulin resistance may contribute to cognitive aging and Alzheimer's diseases. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within insulin resistance-associated genes, such as the ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9), glucokinase regulator (GCKR), and peroxisome proliferator activated receptor gamma (PPARG) genes, may be linked with cognitive aging independently and/or through complex interactions in an older Taiwanese population...
2017: PloS One
https://www.readbyqxmd.com/read/28205203/effects-of-different-types-of-exercise-on-body-composition-muscle-strength-and-igf-1-in-the-elderly-with-sarcopenic-obesity
#3
Hung-Ting Chen, Yu-Chun Chung, Yu-Jen Chen, Sung-Yen Ho, Huey-June Wu
OBJECTIVES: To investigate the influence of resistance training (RT), aerobic training (AT), or combination training (CT) interventions on the body composition, muscle strength performance, and insulin-like growth factor 1 (IGF-1) of patients with sarcopenic obesity. DESIGN: Randomized controlled trial. SETTING: Community center and research center. PARTICIPANTS: Sixty men and women aged 65-75 with sarcopenic obesity...
February 15, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28201960/hypoglycemia-and-glucocorticoid-free-immunosuppression-are-related-with-low-dehydroepiandrosterone-sulfate-level
#4
Martina Zahradnicka, Frantisek Saudek, Kvetoslav Lipar, Jelena Skibova
BACKGROUND: Low dehydroepiandrosterone sulfate (DHEAS) levels and a high cortisol/DHEAS ratio are associated with higher mortality in elderly, dialyzed, and immunocompromised patients. The role of these hormones in patients with hypoglycemia unawareness (hypo) or in pancreas or islet recipients treated by glucocorticoid-free immunosuppressive regimen (IS) has not been studied. OBJECTIVE: The aim of this study was to determine the effects of IS and of recurrent hypoglycemia on DHEAS and adrenocorticotropic hormone (ACTH) levels in patients with type-1 diabetes (T1DM)...
February 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28178313/association-between-hba1c-and-carotid-atherosclerosis-among-elderly-koreans-with-normal-fasting-glucose
#5
Seung Won Lee, Hyeon Chang Kim, Yong-Ho Lee, Bo Mi Song, Hansol Choi, Ji Hye Park, Yumie Rhee, Chang Oh Kim
AIM: We examined whether glycated haemoglobin (HbA1c) is associated to carotid atherosclerosis in an elderly Korean population with normal fasting glucose. METHODS: Using data from the Korean Urban Rural Elderly study, we conducted a cross-sectional analysis of 1,133 participants (335 men and 798 women) with a mean age of 71.8 years. All participants had fasting blood glucose less than 100mg/dL (5.6 mmol/L) and HbA1c level below 6.5% (48 mmol/mol). They were also free from a history of cardiovascular disease, known type 2 diabetes mellitus or use of anti-diabetes medications...
2017: PloS One
https://www.readbyqxmd.com/read/28167325/lower-prevalence-of-proliferative-diabetic-retinopathy-in-elderly-onset-patients-with-diabetes
#6
Siqin Zhang, Jianglan Wang, Chenxi Song, Leilei Zhu, Yerong Yu
AIMS: To assess diabetic retinopathy (DR) prevalence between elderly onset and younger onset diabetes with similar diabetes duration and evaluate the association between DR prevalence and serum insulin-like growth factor 1 (IGF-1) levels. METHODS: A total of 1787 patients with diabetes were enrolled between January 2010 and November 2015. Fundoscopy examination was performed. Patients were divided into three groups by age of diagnosis (<45, 45-64, and ⩾65years) for the analysis of the prevalence of DR...
September 21, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28165405/circulating-docosahexaenoic-acid-associates-with-insulin-dependent-skeletal-muscle-and-whole-body-glucose-uptake-in-older-women-born-from-normal-weight-mothers
#7
Robert M Badeau, Miikka-Juhani Honka, Marco Bucci, Patricia Iozzo, Johan G Eriksson, Pirjo Nuutila
BACKGROUND: Obesity among pregnant women is common, and their offspring are predisposed to obesity, insulin resistance, and diabetes. The circulating metabolites that are related to insulin resistance and are associated with this decreased tissue-specific uptake are unknown. Here, we assessed metabolite profiles in elderly women who were either female offspring from obese mothers (OOM) or offspring of lean mothers (OLM). Metabolic changes were tested for associations with metrics for insulin resistance...
February 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28160328/ethnic-differences-in-male-reproductive-hormones-and-relationships-with-adiposity-and-insulin-resistance-in-older-men
#8
Robert J A H Eendebak, Agnieszka Swiecicka, Piotr S Gromski, Stephen R Pye, Terence W O'Neill, Alan Marshall, Brian G Keevil, Gindo Tampubolon, Royston Goodacre, Frederick C W Wu, Martin K Rutter
OBJECTIVES: To assess ethnic differences in male reproductive hormone levels and to determine if any differences are explained by adiposity, insulin resistance (IR), or comorbidities in older men. DESIGN: Multi-ethnic cross-sectional observational study. PARTICIPANTS: Community dwelling middle-aged and elderly men residing in the U.K. aged 40-84 years of South Asian (SA; n=180), White European (WE; n=328) or African Caribbean (AC; n=166) origin...
February 3, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28156156/hyperglycemia-and-hypoglycemia-in-patients-with-diabetes-in-skilled-nursing-facilities
#9
Rushad Patell, Denis Nigmatoulline, James Bena, Do Gyun Kim, Barbara Messinger-Rapport, M Cecilia Lansang
BACKGROUND: Endocrinologists are faced with a growing elderly patient population with diabetes (DM), some of whom are in skilled nursing facilities (SNF). Efforts at managing their DM is hampered by concerns for hypoglycemia. This study aimed to determine the frequency of hypo- and hyperglycemia in SNFs, and associated factors. METHODS: We reviewed medical records of 200 consecutive residents admitted to 2 SNFs in the Cleveland area in 2014 with documented DM, aged ≥ 65 years...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28150034/association-of-dpp-4-activity-with-bmd-body-composition-and-incident-hip-fracture-the-cardiovascular-health-study
#10
L D Carbone, P Bůžková, H A Fink, J A Robbins, M Bethel, C M Isales, W D Hill
: There was no association of plasma DPP-4 activity levels with bone mineral density (BMD), body composition, or incident hip fractures in a cohort of elderly community-dwelling adults. INTRODUCTION: Dipeptidyl peptidase IV (DPP-4) inactivates several key hormones including those that stimulate postprandial insulin secretion, and DPP-4 inhibitors (gliptins) are approved to treat diabetes. While DPP-4 is known to modulate osteogenesis, the relationship between DPP-4 activity and skeletal health is uncertain...
February 2, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28142050/relationship-between-pulmonary-function-and-elevated-glycated-hemoglobin-levels-in-health-checkups-a-cross-sectional-observational-study-in-japanese-participants
#11
Saigo Baba, Toru Takashima, Miki Hirota, Michihiro Kawashima, Etsuo Horikawa
BACKGROUND: Insulin resistance has been associated with cytokines, including interleukin-6 and tumor necrosis factor alpha soluble receptor, both of which are elevated in chronic obstructive pulmonary disease (COPD). Few studies have investigated the relationship between pulmonary function tests using spirometry (PFT) and fasting plasma glucose (FPG) or glycated hemoglobin (HbA1c) levels in Japanese participants. The purpose of this study was to clarify the relationship between PFT in Japanese people who had health checkups and their FPG or HbA1c levels...
January 27, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28132777/reduced-muscle-mass-in-middle-aged-depressed-patients-is-associated-with-male-gender-and-chronicity
#12
Kai G Kahl, Ferdi Utanir, Ulrich Schweiger, Tillmann H Krüger, Helge Frieling, Stefan Bleich, Marcel Gutberlet, Dagmar Hartung
OBJECTIVE: Reduced muscle mass is a characteristic finding in sarcopenia, the central element of physical frailty syndrome, and a major cause of physical function decay, morbidity and mortality in the elderly. Studies so far demonstrated reduced muscle mass in depressed patients with an average age over 60years.An open question is whether muscle mass reduction is already observed earlier. Therefore, muscle mass was assessed in middle-aged male and female depressive patients, and the findings were related to indicators of hypothalamus-pituitary adrenal axis activation, lifestyle factors, endocrine and immune measures...
January 26, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28123476/the-expression-of-insulin-like-growth-factor-1-in-senior-patients-with-diabetes-and-dementia
#13
Yan-Ling Zhou, Shu-Qing Liu, Bin Yuan, Ning Lu
This study was conducted to investigate the expression of insulin-like growth factor-1 (IGF-1) in elderly patients with diabetes and dementia and to analyze the expression mechanism. A total of 30 senior patients with diabetes and dementia (group A), 30 senior patients with dementia but no diabetes (group B), 30 senior patients with diabetes but no dementia (group C), and 30 healthy seniors (group D) were continuously selected. The ELISA method was used to test the level of serum IGF-1, β-amyloid peptide (Aβ) and the phosphorylation of immunohistochemical staining of microtubule associated protein (tau protein)...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28107806/cognitive-function-and-insulin-resistance-in-elderly-patients-with-type-2-diabetes
#14
Lina Ma, Yun Li
PURPOSE: To explore the relationship between cognitive impairment and insulin resistance (IR) in elderly patients with type-2 diabetes mellitus. MATERIALS AND METHODS: Two hundred and twelve elderly patients with type-2 diabetes were enrolled in this study and assigned into either the cognitive impairment group (n = 100) or the normal cognitive group (n = 112). Gender, age, education, body mass index (BMI), total cholesterol, triglyceride, low-density lipoprotein cholesterol, creatinine (Cr), fasting plasma glucose, fasting insulin (FINS) and homeostasis model of assessment for IR index (HOMA-IR) were compared between the two groups...
March 2017: Neurological Research
https://www.readbyqxmd.com/read/28099900/skeletal-muscle-aging-influence-of-oxidative-stress-and-physical-exercise
#15
REVIEW
Mariana Janini Gomes, Paula Felippe Martinez, Luana Urbano Pagan, Ricardo Luiz Damatto, Marcelo Diacardia Mariano Cezar, Aline Regina Ruiz Lima, Katashi Okoshi, Marina Politi Okoshi
Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and mortality. Several factors such as reduced physical activity, hormonal changes, insulin resistance, genetic susceptibility, appetite loss, and nutritional deficiencies are involved in the physiopathology of muscle changes. Sarcopenia is characterized by structural, biochemical, molecular and functional muscle changes...
January 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28076599/applicability-of-the-spoken-knowledge-in-low-literacy-patients-with-diabetes-in-brazilian-elderly
#16
Jonas Gordilho Souza, Daniel Apolinario, José Marcelo Farfel, Omar Jaluul, Regina Miksian Magaldi, Alexandre Leopold Busse, Flávia Campora, Wilson Jacob-Filho
Objective: To translate, adapt and evaluate the properties of a Brazilian Portuguese version of the Spoken Knowledge in Low Literacy Patients with Diabetes, which is a questionnaire that evaluate diabetes knowledge. Methods: A cross-sectional study with type 2 diabetes patients aged ≥60 years, seen at a public healthcare organization in the city of Sao Paulo (SP). After the development of the Portuguese version, we evaluated the psychometrics properties and the association with sociodemographic and clinical variables...
October 2016: Einstein
https://www.readbyqxmd.com/read/28056470/-anti-diabetic-medication-during-the-first-four-years-of-treatment-a-study-based-on-claims-data
#17
Veronika Lappe, Ingrid Köster, Ingrid Schubert
: Background Ever since the UKPDS study reassessed the usefulness of the substance metformin in 1998, it has been the first-line medication in anti-diabetic treatment. In addition, new classes and agents released on the market have given rise to new treatment options. The present study investigates prescription practice at the onset of treatment and in the years thereafter and measures it against German diabetes guidelines. Database and Methods Database: Statutory health insurance sample AOK/KV Hesse; Ages: 40 and over (N = 142514)...
January 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28056430/the-effects-of-sitagliptin-a-dpp-4-inhibitor-on-cognitive-functions-in-elderly-diabetic-patients-with-or-without-alzheimer-s-disease
#18
Ahmet Turan Isik, Pinar Soysal, Adnan Yay, Cansu Usarel
AIMS: The present study aimed to evaluate effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4I), on cognitive functions in elderly diabetic patients with and without cognitive impairment. METHODS: 253 elderly patients with type 2DM, were enrolled in this prospective and observational study. After comprehensive geriatric assessment, the patients were divided into either sitagliptin or non-sitagliptin group. RESULTS: A total of 205 patients who completed the study (52 with Alzheimer's Disease (AD)) were re-evaluated 6months later...
January 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28043897/natural-products-against-alzheimer-s-disease-pharmaco-therapeutics-and-biotechnological-interventions
#19
REVIEW
Abhijit Dey, Raktim Bhattacharya, Anuradha Mukherjee, Devendra Kumar Pandey
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease associated with memory and cognition impairment ultimately leading to death. It is the commonest reason of dementia in elderly populations mostly affecting beyond the age of 65. The pathogenesis is indicated by accumulation of the amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFT) in brain tissues and hyperphosphorylation of tau protein in neurons. The main cause is considered to be the formation of reactive oxygen species (ROS) due to oxidative stress...
December 30, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/27972164/real-world-tolerability-and-effectiveness-of-exenatide-once-weekly-compared-to-basal-insulin-among-elderly-patients-with-type-2-diabetes-t2d
#20
J D Seeger, A M Loughlin, Q Qiao, A P Nunes, S Ezzy, L A Yochum, C R Clifford, R Gately, P Ohman, D D Dore
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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