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https://www.readbyqxmd.com/read/29238004/frailty-in-elderly-diabetes-patients
#1
Toshihiko Yanase, Ikumi Yanagita, Kazuo Muta, Hajime Nawata
Frailty is a state of vulnerability and a consequence of cumulative decline in multiple physiological systems over a lifespan. The occurrence of frailty depends on deterioration in muscle and nerve function, declining cardiopulmonary reserve and loss of executive function. Diabetes mellitus (DM) often causes functional impairment in each of the above systems, thus leading to a loss of whole body homeostasis and deterioration in physical function. Inability of self-management in DM patients may also have considerable impact on the development of sarcopenia/frailty...
December 14, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29228945/trends-in-incidence-of-proximal-humerus-fractures-surgical-procedures-and-outcomes-among-elderly-hospitalized-patients-with-and-without-type-2-diabetes-in-spain-2001-2013
#2
Maria Angeles Martinez-Huedo, Rodrigo Jiménez-García, Eduardo Mora-Zamorano, Valentín Hernández-Barrera, Manuel Villanueva-Martinez, Ana Lopez-de-Andres
BACKGROUND: Several studies have reported that diabetic persons have an increased risk for fractures than non-diabetes patients. The association between proximal humerus fractures and type 2 diabetes (T2DM) is unclear and some studies point to insulin treatment, hypoglycaemic episodes consequently to inadequate control of diabetes or, more recently, to an alteration of trabecular bone. We examined trends in the incidence of proximal humerus fractures, surgical procedures and outcomes among hospitalized patients aged ≥65 years, with and without T2DM in Spain, 2001-2013...
December 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29224090/men-are-from-mars-women-are-from-venus-sex-differences-in-insulin-action-and-secretion
#3
Ananda Basu, Simmi Dube, Rita Basu
Sex difference plays a substantial role in the regulation of glucose metabolism in healthy glucose-tolerant humans. The factors which may contribute to the sex-related differences in glucose metabolism include differences in lifestyle (diet and exercise), sex hormones, and body composition. Several epidemiological and observational studies have noted that impaired glucose tolerance is more common in women than men. Some of these studies have attributed this to differences in body composition, while others have attributed impaired insulin sensitivity as a cause of impaired glucose tolerance in women...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29215660/-prioritization-of-non-recommended-clinical-activities-in-primary-care
#4
L García Mochon, A Olry de Labry Lima, C Bermudez-Tamayo
OBJECTIVE: To prioritize non-recommended clinical activities in Primary Care (PC), from "Do not do" recommendations listed by the Sociedad Española de Medicina de Familia y Comunitaria (Semfyc), according to expert consensus (physicians, nurses and pharmacists). METHODS: The consensus for the prioritization of non-recommended practices in PC was performed through an online procedure. We used as a base the list of "do not-do" recommendations of the SEMFYC. We asked the experts to prioritize practices that should be de-adopted in PC, based on four prioritization criteria: frequency of occurrence, cost of the activity, ease of disposal and damage caused, which were scored from one to five, according to their recommendation...
December 7, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/29209633/protein-intake-especially-vegetable-protein-intake-is-associated-with-higher-skeletal-muscle-mass-in-elderly-patients-with-type-2-diabetes
#5
Akane Miki, Yoshitaka Hashimoto, Shinobu Matsumoto, Emi Ushigome, Takuya Fukuda, Takafumi Sennmaru, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
Background/Aims: Protein intake is important for maintaining muscle mass in general population. However, it remains to be elucidated the association between dietary protein intake and skeletal muscle mass in elderly patients with type 2 diabetes. Methods: In this cross-sectional study of 168 elderly patients with type 2 diabetes, we investigated the relationship between skeletal muscle index (SMI) and protein intake. Bioimpedance analysis was used for measurement for skeletal muscle mass (kg) and SMI (%), which was defined as skeletal muscle mass (kg)/total body weight (kg) × 100...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29208737/genetic-influence-on-the-associations-between-igf-i-and-glucose-metabolism-in-a-cohort-of-elderly-twins
#6
Rikke Beck Jensen, Ajay Thankamony, Klaus K Holst, Joseph A M J L Janssen, Anders Juul, David P Dunger, Pernille Poulsen, Thomas Scheike
OBJECTIVE: IGF-I may be a marker of later metabolic and cardiovascular disease. The interactions between IGF-I and glucose metabolism are multifactorial and there is potential confounding from several secondary effects. In this study we examined the interaction between IGF-I and glucose metabolism in a large cohort of clinically well-characterised elderly twins. DESIGN: A total of 303 twin pairs of the same gender (606 twins) were included in the study; 125 monozygotic and 178 dizygotic twin pairs...
December 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29202033/synthetic-smart-gel-provides-glucose-responsive-insulin-delivery-in-diabetic-mice
#7
Akira Matsumoto, Miyako Tanaka, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-Oka, Hirohito Kuwata, Hironori Yamada, Ibuki Shirakawa, Taiki Miyazawa, Hitoshi Ishii, Kazunori Kataoka, Yoshihiro Ogawa, Yuji Miyahara, Takayoshi Suganami
Although previous studies have attempted to create "electronics-free" insulin delivery systems using glucose oxidase and sugar-binding lectins as a glucose-sensing mechanism, no successful clinical translation has hitherto been made. These protein-based materials are intolerant of long-term use and storage because of their denaturing and/or cytotoxic properties. We provide a solution by designing a protein-free and totally synthetic material-based approach. Capitalizing on the sugar-responsive properties of boronic acid, we have established a synthetic polymer gel-based insulin delivery device confined within a single catheter, which exhibits an artificial pancreas-like function in vivo...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29193561/effectiveness-and-tolerability-of-therapy-with-exenatide-once-weekly-versus-basal-insulin-among-injectable-na%C3%A3-ve-elderly-or-renal-impaired-patients-with-type-2-diabetes-in-the-united-states
#8
Anita M Loughlin, Qing Qiao, Anthony Philip Nunes, Peter Öhman, Stephen Ezzy, Laura Yochum, C Robin Clifford, Robert Gately, David D Dore, John Seeger
AIM: To evaluate the effectiveness and tolerability of exenatide once-weekly (EQW) compared to basal insulin (BI) among injectable-naïve T2DM patients who are elderly or have renal impairment (RI). METHODS AND MATERIALS: Initiators of EQW and BI with T2DM were identified from 2012-2015 within a United States electronic health record database and matched by propensity score. Matched EQW and BI initiators aged 65+ years or who have RI were compared. Weight, HbA1c, eGFR, blood pressure, and lipids were obtained at baseline and quarterly (Q1-Q4) or semi-annually for one year following drug initiation...
November 30, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29190545/six-weeks-of-combined-aerobic-and-resistance-exercise-using-outdoor-exercise-machines-improves-fitness-insulin-resistance-and-chemerin-in-the-korean-elderly-a-pilot-randomized-controlled-trial
#9
Dong-Il Kim, Dong Hoon Lee, Sunghyun Hong, Sung-Won Jo, Young-Shin Won, Justin Y Jeon
BACKGROUND: The aim of this study was to investigate the effect of a six-week-long exercise program using outdoor exercise equipment on fitness, insulin resistance and adipocytokines among Korean elderly. METHODS: A total of 47 participants were randomized into one of the following three groups; control, resistance exercise or combined exercise (aerobic and resistance exercise). The resistance exercise group completed three resistance types of exercise. The combined exercise group completed five exercises, including three resistance types of exercise and two aerobic types of exercise...
November 23, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29178313/association-of-insulin-like-growth-factor-1-bone-mass-and-inflammation-to-low-energy-distal-radius-fractures-and-fracture-healing-in-elderly-women-attending-emergency-care
#10
Simona I Chisalita, Lee Ti Chong, Maciej Wajda, Lars Adolfsson, Mischa Woisetschläger, Anna Spångeus
OBJECTIVE: Elderly patients suffer fractures through low-energy mechanisms. The distal radius is the most frequent fracture localization. Insulin-like growth factor-1 (IGF1) plays an important role in the maintenance of bone mass and its levels decline with advancing age and in states of malnutrition. Our aim was to investigate the association of IGF1 levels, bone mass, nutritional status, and inflammation to low-energy distal radius fractures and also study if fracture healing is influenced by IGF1, nutritional status, and inflammation...
November 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29139589/severe-fasting-hypoglycemia-in-a-child-after-total-pancreatectomy-with-islet-autotransplantation
#11
Jacob M Redel, Jaimie D Nathan, Maisam Abu-El-Haija, Tom K Lin, Joseph J Palermo, Deborah A Elder
TPIAT is an increasingly utilized treatment option for select children with CP. Post-TPIAT fasting hypoglycemia, unrelated to exogenous insulin, is a complication recently reported in adults. This phenomenon has not been described in children. We review a case of severe fasting hypoglycemia in an adolescent female occurring 10 months post-TPIAT. A 12-year-old girl underwent TPIAT for CP. Ten months postoperatively she developed recurrent hypoglycemia on a total daily insulin dose of 0.03 units/kg. Consequently, insulin therapy was discontinued...
November 15, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29122997/level-of-moderate-intensity-leisure-time-physical-activity-and-reduced-mortality-in-middle-aged-and-elderly-chinese
#12
Ying Liu, Wanqing Wen, Yu-Tang Gao, Hong-Lan Li, Gong Yang, Yong-Bing Xiang, Xiao-Ou Shu, Wei Zheng
BACKGROUND: Few studies have prospectively evaluated the association of leisure-time physical activity (LTPA) with mortality in Asians, who are more susceptible to insulin resistance than their Caucasian counterparts. METHODS: Data from two large prospective cohort studies conducted in Shanghai were evaluated. After excluding participants who had a history of cancer, coronary heart disease or stroke at baseline, or who died within the first 3 years after study enrolment, 53 839 men and 66 888 women, followed for an average of 9...
November 9, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29120677/relationships-between-25-oh-d-concentration-sarcopenia-and-homa-ir-in-postmenopausal-korean-women
#13
J H Lee, S Kim, M K Kim, B H Yun, S Cho, Y S Choi, B S Lee, S K Seo
OBJECTIVE: Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyvitamin D concentration, sarcopenia, and insulin resistance in postmenopausal Korean women. METHODS: This study used data from the Korea National Health and Nutrition Examination Survey 2008-2011...
November 9, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29119382/role-of-brown-adipose-tissue-in-metabolic-syndrome-aging-and-cancer-cachexia
#14
REVIEW
Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee
Brown adipose tissue (BAT) plays a fundamental role in maintaining body temperature by producing heat. BAT that had been know to exist only in mammals and the human neonate has received great attention for the treatment of obesity and diabetes due to its important function in energy metabolism, ever since it is recently reported that human adults have functional BAT. In addition, beige adipocytes, brown adipocytes in white adipose tissue (WAT), have also been shown to take part in whole body metabolism. Multiple lines of evidence demonstrated that transplantation or activation of BAT or/and beige adipocytes reversed obesity and improved insulin sensitivity...
November 8, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29115018/relationship-between-exercise-capacity-and-glucose-tolerance-in-cystic-fibrosis
#15
Karla Foster, Guixia Huang, Nanhua Zhang, Joseph Crisalli, Barbara Chini, Raouf Amin, Deborah Elder
BACKGROUND: Improved exercise capacity (EC) and normal glucose tolerance (NGT) are independently associated with favorable outcomes in CF, however, little information on this relationship exists in patients with CF. METHODS: Cardiopulmonary exercise tests, oral glucose tolerance tests (OGTT), and HbA1c values measured within a 12-month period were evaluated on 83 pediatric patients diagnosed with CF. Patients were categorized as having NGT, abnormal glucose tolerance (AGT), or CF-related diabetes (CFRD)...
November 8, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29113459/the-combined-effect-of-vitamin-d-and-parathyroid-hormone-concentrations-on-glucose-homeostasis-in-older-patients-with-prediabetes-a-cross-sectional-study
#16
Spyridon N Karras, Panagiotis Anagnostis, Vasiliki Antonopoulou, Xanthippi Tsekmekidou, Theocharis Koufakis, Dimitrios G Goulis, Pantelis Zebekakis, Kalliopi Kotsa
BACKGROUND: The combined effect of vitamin D and parathyroid hormone on glucose homeostasis has not been adequately investigated. The aim of this study was to examine the role of parathyroid hormone/vitamin D axis on glucose homeostasis in elderly persons with prediabetes. METHODS: Patients with prediabetes ( n = 144) and healthy age-matched controls ( n = 81) were included in this cross-sectional study. Study parameters included anthropometric characteristics, morning fasting glucose (fasting plasma glucose), insulin (fasting plasma insulin), parathyroid hormone, 25-hydroxyvitamin D, homeostasis model assessment of insulin resistance and homeostasis model assessment of β-cell function...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29108358/mid-arm-muscle-circumference-as-a-surrogate-in-predicting-insulin-resistance-in-non-obese-elderly-individuals
#17
Yuan-Ping Chao, Yi-Fen Lai, Tung-Wei Kao, Tao-Chun Peng, Yuan-Yung Lin, Mu-Tsun Shih, Wei-Liang Chen, Li-Wei Wu
The homeostatic model assessment of insulin resistance (HOMA-IR) was used to measure the degree of insulin resistance (IR). Previous literature revealed that mid-arm muscle circumference (MAMC) is one of the anthropometric indicators for nutritional status and the relationship between MAMC and HOMA-IR remains uncertain in the obese and non-obese elderly individuals. The present study included 5,607 participants aged between 60 to 84 years old, using data from the 1999 to 2006 National Health and Nutrition Examination Survey (NHANES)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29106815/high-dose-glucocorticoids-treatment-does-not-induce-severe-hyperglycemia-in-young-patients-with-autoimmune-diseases-by-cgms
#18
Ying Zhou, Yan Zhao, Tao Yuan, Nan Jiang, Yingyue Dong, Yunjiao Yang, Li Wang, Jiuliang Zhao, Le Min, Weigang Zhao
INTRODUCTION: High-dose glucocorticoids (HDG) are used in the treatment of autoimmune diseases. Glucocorticoids-induced hyperglycemia (GIH) is often described in elderly patients. In young patients with autoimmune diseases, however, the risk for GIH has not been well characterized. METHODS: Twenty-four inpatients (median age 32 years (interquatile range 25-42)) with exacerbations of autoimmune diseases, receiving 1-2mg/kg/day prednisone or equivalent methylprednisone, were recruited...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29098651/excess-body-weight-insulin-resistance-and-isolated-systolic-hypertension-potential-pathophysiological-links
#19
Lanfranco D'Elia, Pasquale Strazzullo
Isolated systolic hypertension, the most common form of hypertension in the elderly, but also detectable among young and middle-aged subjects, is independently associated with higher risk of cardiovascular events and all-cause mortality. Among various pathophysiological changes associated with aging, excess body weight and insulin resistance may predispose to this type of hypertension. Overweight or frank obesity and their frequent companion insulin resistance could mediate the development of isolated systolic hypertension through increase in the renin-angiotensin-aldosterone system activity, in the sympathetic tone and in salt-sensitivity, all in turn leading to endothelial dysfunction, arterial stiffness and increase in blood pressure...
November 2, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29095970/failed-recovery-of-glycemic-control-and-myofibrillar-protein-synthesis-with-two-weeks-of-physical-inactivity-in-overweight-pre-diabetic-older-adults
#20
Chris McGlory, Mark T von Allmen, Tanner Stokes, Robert Given Morton, Amy J Hector, Briony A Lago, Amogelang R Raphenya, Brennan K Smith, Andrew G McArthur, Gregory R Steinberg, Steven K Baker, Stuart M Phillips
Background: Physical inactivity impairs insulin sensitivity, which is exacerbated with aging. We examined the impact of two weeks of acute inactivity and recovery on glycemic control, integrated rates of muscle protein synthesis (MPS) in older men and women. Methods: Twenty-two overweight, pre-diabetic older adults (12 men, 10 women, 69 ± 4 yr) undertook 7 d of habitual activity (baseline; BL), step reduction (SR; <1000 steps .d-1 for 14 d), followed by 14d of recovery (RC)...
October 31, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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