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Angiotension converting enzyme

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https://www.readbyqxmd.com/read/27753835/sy-05-1-fibro-inflammatory-changes-during-progression-of-systolic-diastolic-dysfunction-in-the-hypertensive-heart
#1
Hisashi Kai
There is increasing evidence that fibro-inflammatory changes play a role in variety of cardiovascular diseases. We created new rat models to investigate the role of fibro-inflammatory changes in the pathophysiology of systolic and diastolic dysfunction in hypertensive heart. (1) a model of a blood pressure (BP) surge was created by performing abdominal aortic constriction in Wistar-Kyoto rats. Aortic constriction rapidly increased BP and the high BP levels sustained. A BP surge transiently induced MCP-1 and TGF-beta induction, angiotensin converting enzyme activation, and macrophage infiltration, followed by left ventricular (LV) hypertrophy and perivascular reactive fibrosis...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642888/sy-05-1-fibro-inflammatory-changes-during-progression-of-systolic-diastolic-dysfunction-in-the-hypertensive-heart
#2
Hisashi Kai
There is increasing evidence that fibro-inflammatory changes play a role in variety of cardiovascular diseases. We created new rat models to investigate the role of fibro-inflammatory changes in the pathophysiology of systolic and diastolic dysfunction in hypertensive heart. (1) a model of a blood pressure (BP) surge was created by performing abdominal aortic constriction in Wistar-Kyoto rats. Aortic constriction rapidly increased BP and the high BP levels sustained. A BP surge transiently induced MCP-1 and TGF-beta induction, angiotensin converting enzyme activation, and macrophage infiltration, followed by left ventricular (LV) hypertrophy and perivascular reactive fibrosis...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27367218/shared-medical-appointments-impact-on-clinical-and-quality-outcomes-in-veterans-with-diabetes
#3
Marianne D Harris, Susan Kirsh, Patricia A Higgins
Managing diabetes poses substantial challenges to the over 29.1 million Americans afflicted, and is financially overwhelming to the US health care system. One potential strategy is utilizing a group approach to care delivery or shared medical appointment (SMA). The purpose of this 3-year retrospective VA study was to investigate differences in clinical and quality outcome measures in veterans with type 2 diabetes who used SMAs and those who received only usual care (UC) one-on-one with their doctor. This observational, 2-group cohort study used abstracted medical records from a large Midwestern Veterans Administration hospital...
July 2016: Quality Management in Health Care
https://www.readbyqxmd.com/read/27062145/recent-trends-in-utilization-of-antidiabetic-medications-from-2008-2013-a-nation-wide-population-based-study-from-taiwan
#4
Huang-Tz Ou, Kai-Cheng Chang, Ya-Ming Liu, Jin-Shang Wu
BACKGROUND: Studies from other countries have indicated that the utilization patterns of antidiabetic drugs changed significantly after the introduction of newer classes of antidiabetic drugs (e.g., dipeptidyl peptidase-4 inhibitors; DDP4i). Evidence on recent trends of antidiabetic drug utilization in Taiwan is lacking, especially for the time after newer classes of drugs (e.g., DPP4i) were introduced. This study therefore assessed (1) recent trends in the utilization and spending on antidiabetic drugs, (2) change in utilization patterns after newer classes of antidiabetic drugs were introduced, and (3) factors associated with the choice of newer versus older classes of antidiabetic drugs...
April 6, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27025881/diabetic-nephropathy-focus-on-current-and-future-therapeutic-strategies
#5
Riccardo Pofi, Francesca Di Mario, Antonietta Gigante, Edoardo Rosato, Andrea M Isidori, Antonio Amoroso, Rosario Cianci, Biagio Barbano
BACKGROUND: Diabetic nephropathy (DN) is currently the most common cause of end-stage renal disease (ESRD). Although nowadays much is known about its classification, pathogenesis, clinical manifestations and evolution, to date we are not yet able to stop the natural progression of nephropathy in diabetic patients. METHODS: Treatment options are: lifestyle change with close blood pressure monitoring and tight glycemic control. The most common therapies adopted for this condition are Angiotensing Converting Enzyme-inhibitors (ACEi)...
2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/27007221/preparation-of-nanoliposome-loaded-with-peanut-peptide-fraction-stability-and-bioavailability
#6
Kui-Jie Gong, Ai-Min Shi, Hong-Zhi Liu, Li Liu, Hui Hu, Ying Yang, Benu Adhikari, Qiang Wang
Nanoliposome loaded with peanut peptide fraction (PPF) prepared by high pressure microfluidization (HPM) treatment was investigated as well as its stability and bioavailability. PPF showed hydrophilicity character with a solubility of 97.50 ± 2.31 mg mL(-1) in aqueous solution. HPM treatment can prepare nanoliposome but decreased encapsulation efficiency (EE). A pressure of 120 MPa was the appropriate parameter where the particle size and EE of nanolipsome was 79.67 ± 1.85 nm and 65.12 ± 2.96%, respectively...
April 2016: Food & Function
https://www.readbyqxmd.com/read/26788011/vegetable-product-containing-caseinomacropeptide-and-germinated-seed-and-sprouts
#7
Sibel Karakaya, Sedef Nehir El, Sebnem Simsek, Hulya Ilyasoglu Buyukkestelli
In this study vegetable product containing germinated seed and sprouts of lentils and cowpeas, and caseinomacropeptide isolated from whey is produced. Three different forms of vegetable product namely puree (VP), freeze-dried (FD) and drum-dried (DD) are produced. Freeze-dried and DD forms are produced to diversify forms of utilization and to improve functionality such as increased shelf life and decreased storage space. Their beneficial effects on health are determined using in vitro methods. All forms displayed antioxidant activities against DPPH radical and oxygen radical, α-amylase inhibitory activities, bile acid binding capacities, and angiotension converting enzyme (ACE) inhibitory activities...
January 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/26463100/production-of-angiotensin-i-converting-enzyme-inhibitory-ace-i-peptides-during-milk-fermentation-and-their-role-in-reducing-hypertension
#8
Amit Kumar Rai, Samurailatpam Sanjukta, Kumaraswamy Jeyaram
Fermented milk is a potential source of various biologically active peptides with specific health benefits. Angiotensin converting enzyme inhibitory (ACE-I) peptides are one of the most studied bioactive peptides produced during milk fermentation. The presence of these peptides is reported in various fermented milk products such as yoghurt, cheese, sour milk, etc, which are also available as commercial products. Many of the ACE-I peptides formed during milk fermentation are resistant to gastrointestinal digestion and inhibit angiotensin converting enzyme (ACE) in the rennin angiotension system (RAS)...
October 13, 2015: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/26150207/tertiary-syphilis-and-kaposi-sarcoma-mistaken-for-systemic-sarcoidosis-in-an-hiv-negative-patient
#9
M C Anyasodor, A Bewley
We describe a case of an HIV-negative man who was mistakenly diagnosed as having systemic sarcoidosis, which led to a delay in diagnosing tertiary syphilis and Kaposi sarcoma (KS). The patient presented initially with scrotal swelling and leg oedema. Initial blood tests were unremarkable and HIV testing was negative. The patient then developed unilateral limb weakness. Computed tomography showed lung lesions and hilar lymphadenopathy, while magnetic resonance imaging showed an increased signal in the cervical cord...
December 2015: British Journal of Dermatology
https://www.readbyqxmd.com/read/25905080/association-between-insertion-deletion-polymorphism-in-angiotension-converting-enzyme-and-susceptibility-to-schizophrenia
#10
Hajar Mazaheri, Mostafa Saadat
BACKGROUND: The activity of angiotension converting enzyme (ACE; OMIM: 106180) in different brain regions of patients with schizophrenia changed, suggesting a possible involvement of ACE in psychiatric disorders. Genetic polymorphism of insertion/deletion (I/D; dbSNP rs4646994) in the gene encoding ACE has been well defined. METHODS: The present case-control study was performed on 363 (268 males, 95 females) in-patients with schizophrenia diagnosis, and 363 (268 males, 95 females) healthy blood donor controls...
March 2015: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/25775409/second-trimester-angiotensing-converting-enzyme-and-uterine-artery-doppler-as-predictors-of-preeclampsia-in-a-high-risk-population
#11
Ana Martínez-Ruiz, María Desamparados Sarabia-Meseguer, Juan Antonio Vílchez, Joaquín Pérez-Fornieles, Juan Luis Delgado-Marín, Isabel Tovar-Zapata, Jose Antonio Noguera-Velasco
OBJECTIVE: To investigate whether serum angiotensing-converting enzyme (ACE) and uterine artery Doppler (UAD) are useful markers as predictors of preeclampsia (PE) in a high-risk population. METHODS: Patients at risk of PE (n = 68) were subclassified as having PE (n = 8) or no PE (n = 60). Blood samples were obtained between 19 and 22 weeks of gestation. Doppler ultrasound of the uterine arteries was done at the time of blood sampling. Maternal serum ACE was determined through spectrophotometry assay (A15 Biosystem, ATOM, Barcelona, Spain)...
May 2015: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/25538486/-99m-tc-diethylenetriaminepentacetic-acid-angiotension-coverting-enzyme-inhibitor-renography-as-screening-test-for-renovascular-hypertension-in-unilateral-small-kidney-a-prospective-study
#12
Masood Ul Hassan, Shoukat H Khan, Mohd Ashraf, Saleem Najar, Feroz Shaheen
To know the probability of renal artery stenosis (RAS) in unilateral small kidney and function of the unilateral small kidney, which includes glomerular filtration rate, differential function, uptake, Tmax by (99m)Tc diethylenetriaminepentacetic acid (DTPA) base and (99m)Tc DTPA angiotensin converting enzyme (ACE) inhibition scan. All our patients were subjected to (99m)Tc DTPA ACE inhibition renal scintigraphy. All the patients underwent either computed tomography (CT) angiography and magnetic resonance (MR) angiography was done in those patients in which kidney function test was deranged...
September 2014: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/25440357/orolingual-angiodema-associated-with-alteplase-treatment-of-acute-stroke-a-reappraisal
#13
Ana Sofia Correia, Gonçalo Matias, Sofia Calado, Ana Lourenço, Miguel Viana-Baptista
BACKGROUND: Orolingual angioedema has been increasingly recognized as a potentially life-threatening complication associated with alteplase treatment of stroke. Concomitant treatment with an angiotension converting enzyme inhibitor (ACEi) and localization of infarction in the territory of middle cerebral artery seem to be associated with a higher risk of this complication. METHODS: We report the cases of orolingual angioedema among the patients undergoing alteplase treatment in our Stroke Unit...
January 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/25376822/-the-prevalence-of-risk-factors-and-status-of-clinical-practice-patterns-among-hospitalized-patients-with-acute-coronary-syndromes
#14
Wei Wang, Dong Zhao, Jun Liu, Yue Qi, Jiayi Sun, Jing Liu
OBJECTIVE: To analyze the distribution of multiple risk factors for hospitalized patients with acute coronary syndromes (ACS) and explore the status and determinants of drug usage recommended by the guideline. METHODS: This was a multi-center cross-sectional study in 34 hospitals from 22 provinces in China. About ninety ACS patients were consecutively enrolled from each hospital since April 15, 2012 according to a standard protocol. Totally, 3 253 patients with complete data were analyzed in this study...
August 2014: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/25312666/-meta-analysis-of-the-association-between-angiotension-converting-enzyme-i-d-polymorphism-and-susceptibility-to-children-with-henoch-sch%C3%A3-nlein-purpura-or-henoch-sch%C3%A3-lein-purpura-nephritis
#15
Huiling Li, Daxing Zhao, Qi Yang
OBJECTIVE: To explore the relationship between angiotension-converting enzyme (ACE) I/D polymorphism and susceptibility to Henoch-Schönlein purpura or Henoch-Schönlein purpura nephritis (HSP/HSPN) especially among Chinese children. METHODS: The publications up to December 31, 2013 from PubMed, Embase, Google Scholar, Springer Link, Highwire, Cochrane, ISI, CNKI and Wanfang databases were searched for relevant literature on the association between ACE I/D polymorphism and pediatric HSP/HSPN...
July 8, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/25023137/acute-adriamycin-induced-cardiotoxicity-is-exacerbated-by-angiotension-ii
#16
Eylem Taskin, Elvan Kunduz Kindap, Kalender Ozdogan, Mukerrem Betul Yerer Aycan, Nurcan Dursun
Adriamycin (ADR) increases the production of reactive oxygen species (ROS), which diminishes mitochondrial function. Angiotensin-II stimulates mitochondrial ROS generation. The aim of the study was to examine whether angiotensin converting enzyme (ACE) or renin inhibitors protect against ADR-induced mitochondrial function impairment. Rats were divided into five groups as control, ADR, co-treatment ADR with captopril, co-treatment ADR with aliskiren, co-treatment ADR with both captopril and aliskiren. Left ventricular function and blood pressures were assessed at the end of treatment period...
January 2016: Cytotechnology
https://www.readbyqxmd.com/read/24553088/atrial-fibrillation-in-essential-hypertension-an-issue-of-concern
#17
REVIEW
Li-Qun Zhao, Shao-Wen Liu
Many clinical studies indicate that atrial fibrillation is closely related to hypertension. Atrial fibrillation is not only associated with the level of blood pressure (BP) but also with the circadian rhythms of BP. However, the underlying mechanisms of atrial fibrillation in essential hypertension patients remain largely unknown. Hypertension may facilitate the onset and persistence of atrial fibrillation by stretch-induced changes in the repolarization of atrial myocytes (triggers of atrial fibrillation) and atrial remodeling (structural and electrical remodeling)...
February 2014: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/24255673/prognosis-of-patients-with-heart-failure-and-reduced-ejection-fraction-in-china
#18
Yu Xu, Yanan Shi, Zhongyu Zhu, Changhe Cui, Bei Li, Fang Chen, Dan Li, Songhu Chen, Yang Guo
The present study aimed to investigate the 5-year survival and medication status of patients with chronic heart failure (HF) and reduced ejection fraction (HFrEF) in China. This study is a single-center, retrospective study and patients with HF and a left ventricular ejection fraction (LVEF) of ≤45%, were consecutively enrolled. The study population of 685 patients was divided into two groups, namely, LVEF ≤35 (n=371) and LVEF 36-45% (n=314). The patients were followed up for a median of 31 months (range, 8-61 months) and during this period, 24% of patients receiving angiotension-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) treatment and 23% of those receiving β-blockers reached the maximum tolerated dose...
December 2013: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/24247033/angioedema-from-recombinant-tpa-administration-case-report-and-pathophysiology-review
#19
REVIEW
Alison Foster-Goldman, Danielle McCarthy
Angioedema is an uncommon, yet morbid, adverse reaction to recombinant tissue plasminogen activator (rtPA) administration for ischemic stroke. Orolingual edema may preclude completion of rtPA therapy and cause potential airway compromise. Few case reports and case series have examined the incidence of angioedema and anaphylaxis related to this common stroke therapy. We report a case of orolingual edema and bleeding in a patient who received rtPA for acute ischemic stroke who was concurrently on an angiotension-converting enzyme inhibitor and discuss the pathophysiology of this reaction...
November 2013: American Journal of Therapeutics
https://www.readbyqxmd.com/read/23937443/pharmacological-treatment-for-keloids
#20
REVIEW
Chenyu Huang, Rei Ogawa
INTRODUCTION: Keloids are fibroproliferative disorders that are characterized by histological accumulation of collagens and fibroblasts, refractory clinical symptoms such as itching, topical invasiveness, and frequent postsurgical recurrence. At present, to treat or prevent keloids, new drugs are currently being designed and the pharmaceutical indications of known drugs are being expanded. AREAS COVERED: The current pharmacological interventions for keloids are mainly described on the basis of the various hypotheses on keloid etiology and the keloid ingredients that are targeted...
October 2013: Expert Opinion on Pharmacotherapy
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