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Philip C. Calder

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https://www.readbyqxmd.com/read/27764229/oral-administration-of-linoleic-acid-induces-new-vessel-formation-and-improves-skin-wound-healing-in-diabetic-rats
#1
Hosana G Rodrigues, Marco A R Vinolo, Fabio T Sato, Juliana Magdalon, Carolina M C Kuhl, Ana S Yamagata, Ana Flávia M Pessoa, Gabriella Malheiros, Marinilce F Dos Santos, Camila Lima, Sandra H Farsky, Niels O S Camara, Maria R Williner, Claudio A Bernal, Philip C Calder, Rui Curi
INTRODUCTION: Impaired wound healing has been widely reported in diabetes. Linoleic acid (LA) accelerates the skin wound healing process in non-diabetic rats. However, LA has not been tested in diabetic animals. OBJECTIVES: We investigated whether oral administration of pure LA improves wound healing in streptozotocin-induced diabetic rats. METHODS: Dorsal wounds were induced in streptozotocin-induced type-1 diabetic rats treated or not with LA (0...
2016: PloS One
https://www.readbyqxmd.com/read/27637335/the-impact-of-an-omega-3-fatty-acid-rich-lipid-emulsion-on-fatty-acid-profiles-in-critically-ill-septic-patients
#2
Thomas C Hall, Dilraj K Bilku, Christopher P Neal, Jill Cooke, Helena L Fisk, Philip C Calder, Ashley R Dennison
BACKGROUND: Death from sepsis in the intensive therapy unit (ITU) is frequently preceded by the development of multiple organ failure as a result of uncontrolled inflammation. Treatment with omega-3 (n-3) fatty acids (FAs), principally eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been demonstrated to attenuate the effects of uncontrolled inflammation and may be clinically beneficial in reducing mortality from organ dysfunction. Fish oil (FO) is a source of EPA and DHA...
September 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27629051/maternal-serum-retinol-and-%C3%AE-carotene-concentrations-and-neonatal-bone-mineralization-results-from-the-southampton-women-s-survey-cohort
#3
Mina N Händel, Rebecca J Moon, Philip Titcombe, Bo Abrahamsen, Berit L Heitmann, Philip C Calder, Elaine M Dennison, Sian M Robinson, Keith M Godfrey, Hazel M Inskip, Cyrus Cooper, Nicholas C Harvey
BACKGROUND: Studies in older adults and animals have suggested contrasting relations between bone health and different vitamin A compounds. To our knowledge, the associations between maternal vitamin A status and offspring bone development have not previously been elucidated. OBJECTIVE: We examined the associations between maternal serum retinol and β-carotene concentrations during late pregnancy and offspring bone mineralization assessed at birth with the use of dual-energy X-ray absorptiometry...
October 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27544079/what-is-the-impact-of-n-3-pufas-on-inflammation-markers-in-type-2-diabetic-mellitus-populations-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
REVIEW
Ning Lin, Jiao-Jiao Shi, Yun-Ming Li, Xin-Yan Zhang, Yi Chen, Philip C Calder, Li-Jun Tang
OBJECTIVES: To explore the possible role of n-3 polyunsaturated fatty acids (PUFAs) in lowering inflammation markers in individuals with type 2 diabetes mellitus. METHODS: PubMed, CNKI and Cochrane databases were searched until December 30, 2015; references from papers or reviews were also retrieved and screened. Screening was performed by two independent researchers, and randomized controlled trials reporting the specific n-3 PUFA type, dose, frequency, and duration of treatment, as well as the baseline and follow-up concentrations of inflammation markers, including interleukin 2 (IL-2), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP), were selected for final analysis...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27531277/omega-3-fatty-acid-supplementation-influences-the-whole-blood-transcriptome-in-women-with-obesity-associated-with-pro-resolving-lipid-mediator-production
#5
Anna Polus, Barbara Zapala, Urszula Razny, Anna Gielicz, Beata Kiec-Wilk, Malgorzata Malczewska-Malec, Marek Sanak, Caroline E Childs, Philip C Calder, Aldona Dembinska-Kiec
The n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may reduce low-grade inflammation associated with obesity. The relationship between therapeutic response to n-3 PUFAs and modification of the transcriptome in obesity or metabolic syndrome remains to be explored. Blood samples were obtained from women with obesity before and after three-months supplementation with a moderate dose of n-3 PUFAs (1.8g EPA+DHA per day) or from controls. n-3 PUFAs (GC) and plasma concentrations of lipoxins, resolvins, protectin X (GC-MS/MS) and inflammatory markers (ELISA) were measured...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27497519/fatty-acid-status-and-antioxidant-defense-system-in-mothers-and-their-newborns-after-salmon-intake-during-late-pregnancy
#6
Cruz E Garcia-Rodriguez, Josune Olza, Maria D Mesa, Concepcion M Aguilera, Elizabeth A Miles, Paul S Noakes, Maria Vlachava, Lefkothea-Stella Kremmyda, Norma D Diaper, Keith M Godfrey, Philip C Calder, Angel Gil
OBJECTIVE: The aim of the present study was to assess the maternal and newborn status of erythrocyte fatty acids and the antioxidant defense system after the intake of two portions of salmon per week during late pregnancy. METHODS: Pregnant women (N = 123) were randomly assigned to continue their habitual diet, which was low in oily fish (control group, n = 61) or to consume two 150-g salmon portions per week (salmon group, n = 62) beginning at 20 wk of gestation and lasting until delivery...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27496755/metabolism-and-functional-effects-of-plant-derived-omega-3-fatty-acids-in-humans
#7
REVIEW
Ella J Baker, Elizabeth A Miles, Graham C Burdge, Parveen Yaqoob, Philip C Calder
Alpha-linolenic acid (ALA) is an essential fatty acid and the substrate for the synthesis of longer-chain, more unsaturated ω-3 fatty acids, eicosapentaenoic acid (EPA), docosapentaenoic acid and docosahexaenoic acid (DHA). EPA and DHA are associated with human health benefits. The primary source of EPA and DHA is seafood. There is a need for sustainable sources of biologically active ω-3 fatty acids. Certain plants contain high concentrations of ALA and stearidonic acid (SDA). Here we review the literature on the metabolism of ALA and SDA in humans, the impact of increased ALA and SDA consumption on concentrations of EPA and DHA in blood and cell lipid pools, and the extent to which ALA and SDA might have health benefits...
August 3, 2016: Progress in Lipid Research
https://www.readbyqxmd.com/read/27492754/immunopharmacology-of-fatty-acids
#8
EDITORIAL
Philip C Calder, Linette E M Willemsen
No abstract text is available yet for this article.
August 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27424661/lipid-structure-does-not-modify-incorporation-of-epa-and-dha-into-blood-lipids-in-healthy-adults-a-randomised-controlled-trial
#9
Annette L West, Graham C Burdge, Philip C Calder
Dietary supplementation is an effective means to improve EPA and DHA status. However, it is unclear whether lipid structure affects EPA+DHA bioavailability. We determined the effect of consuming different EPA and DHA lipid structures on their concentrations in blood during the postprandial period and during dietary supplementation compared with unmodified fish oil TAG (uTAG). In a postprandial cross-over study, healthy men (n 9) consumed in random order test meals containing 1·1 g EPA+0·37 g DHA as either uTAG, re-esterified TAG, free fatty acids (FFA) or ethyl esters (EE)...
September 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27305954/impairment-of-lysophospholipid-metabolism-in-obesity-altered-plasma-profile-and-desensitization-to-the-modulatory-properties-of-n-3-polyunsaturated-fatty-acids-in-a-randomized-controlled-trial
#10
Josep M Del Bas, Antoni Caimari, Maria Isabel Rodriguez-Naranjo, Caroline E Childs, Carolina Paras Chavez, Annette L West, Elizabeth A Miles, Lluis Arola, Philip C Calder
BACKGROUND: Plasma lysophospholipids have emerged as signaling molecules with important effects on inflammation, insulin resistance, and fatty liver disease, each of which is linked closely to obesity. Dietary n-3 (ω-3) polyunsaturated fatty acids (PUFAs) may be able to improve these conditions. OBJECTIVE: The objective of this study was to assess the response of plasma lysophospholipids to obesity, n-3 PUFA consumption, and a high-fat meal challenge to better understand the role of lysophospholipid metabolism in the progression of obesity-related disorders...
August 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27173774/lipids-a-hole-in-the-diet-heart-hypothesis
#11
Philip C Calder
No abstract text is available yet for this article.
July 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27155027/immune-biomarkers-in-the-spectrum-of-childhood-noncommunicable-diseases
#12
REVIEW
Chrysanthi Skevaki, Jolice Van den Berg, Nicholas Jones, Johan Garssen, Peter Vuillermin, Michael Levin, Alan Landay, Harald Renz, Philip C Calder, Catherine A Thornton
A biomarker is an accurately and reproducibly quantifiable biological characteristic that provides an objective measure of health status or disease. Benefits of biomarkers include identification of therapeutic targets, monitoring of clinical interventions, and development of personalized (or precision) medicine. Challenges to the use of biomarkers include optimizing sample collection, processing and storage, validation, and often the need for sophisticated laboratory and bioinformatics approaches. Biomarkers offer better understanding of disease processes and should benefit the early detection, treatment, and management of multiple noncommunicable diseases (NCDs)...
May 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27106721/higher-body-fat-percentage-is-associated-with-enhanced-temperature-perception-in-nafld-results-from-the-randomised-wessex-evaluation-of-fatty-liver-and-cardiovascular-markers-in-nafld-with-omacor-therapy-trial-welcome-trial
#13
Geraldine F Clough, Keith G McCormick, Eleonora Scorletti, Lokpal Bhatia, Philip C Calder, Michael J Griffin, Christopher D Byrne
AIMS/HYPOTHESIS: The effect of n-3 fatty acid treatment on temperature perception as a sensory nerve function modality is uncertain. In patients with non-alcoholic fatty liver disease (NAFLD) both with and without type 2 diabetes, we: (1) tested whether 15-18 months' treatment with 4 g/day of docosahexaenoic plus eicosapentaenoic acid (DHA+EPA) improved hot (HPT) and cold (CPT) temperature perception thresholds and (2) explored factors associated with HPT and CPT, in a randomised, double-blind, placebo-controlled trial...
July 2016: Diabetologia
https://www.readbyqxmd.com/read/26925376/effect-of-caloric-restriction-with-or-without-n-3-polyunsaturated-fatty-acids-on-insulin-sensitivity-in-obese-subjects-a-randomized-placebo-controlled-trial
#14
Urszula Razny, Beata Kiec-Wilk, Anna Polus, Joanna Goralska, Malgorzata Malczewska-Malec, Dominika Wnek, Anna Zdzienicka, Anna Gruca, Caroline E Childs, Maria Kapusta, Krystyna Slowinska-Solnica, Philip C Calder, Aldona Dembinska-Kiec
BACKGROUND: Caloric restriction and n-3 polyunsaturated fatty acid (PUFA) supplementation protect from some of the metabolic complications. The aim of this study was to assess the influence of a low calorie diet with or without n-3 PUFA supplementation on glucose dependent insulinotropic polypeptide (GIP) output and insulin sensitivity markers in obese subjects. METHODS: Obese, non-diabetic subjects (BMI 30-40 kg/m(2)) and aged 25-65 yr. were put on low calorie diet (1200-1500 kcal/day) supplemented with either 1...
December 2015: BBA Clinical
https://www.readbyqxmd.com/read/26878675/composition-differences-between-organic-and-conventional-meat-a-systematic-literature-review-and-meta-analysis
#15
REVIEW
Dominika Średnicka-Tober, Marcin Barański, Chris Seal, Roy Sanderson, Charles Benbrook, Håvard Steinshamn, Joanna Gromadzka-Ostrowska, Ewa Rembiałkowska, Krystyna Skwarło-Sońta, Mick Eyre, Giulio Cozzi, Mette Krogh Larsen, Teresa Jordon, Urs Niggli, Tomasz Sakowski, Philip C Calder, Graham C Burdge, Smaragda Sotiraki, Alexandros Stefanakis, Halil Yolcu, Sokratis Stergiadis, Eleni Chatzidimitriou, Gillian Butler, Gavin Stewart, Carlo Leifert
Demand for organic meat is partially driven by consumer perceptions that organic foods are more nutritious than non-organic foods. However, there have been no systematic reviews comparing specifically the nutrient content of organic and conventionally produced meat. In this study, we report results of a meta-analysis based on sixty-seven published studies comparing the composition of organic and non-organic meat products. For many nutritionally relevant compounds (e.g. minerals, antioxidants and most individual fatty acids (FA)), the evidence base was too weak for meaningful meta-analyses...
March 28, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/26878105/higher-pufa-and-n-3-pufa-conjugated-linoleic-acid-%C3%AE-tocopherol-and-iron-but-lower-iodine-and-selenium-concentrations-in-organic-milk-a-systematic-literature-review-and-meta-and-redundancy-analyses
#16
REVIEW
Dominika Średnicka-Tober, Marcin Barański, Chris J Seal, Roy Sanderson, Charles Benbrook, Håvard Steinshamn, Joanna Gromadzka-Ostrowska, Ewa Rembiałkowska, Krystyna Skwarło-Sońta, Mick Eyre, Giulio Cozzi, Mette Krogh Larsen, Teresa Jordon, Urs Niggli, Tomasz Sakowski, Philip C Calder, Graham C Burdge, Smaragda Sotiraki, Alexandros Stefanakis, Sokratis Stergiadis, Halil Yolcu, Eleni Chatzidimitriou, Gillian Butler, Gavin Stewart, Carlo Leifert
Demand for organic milk is partially driven by consumer perceptions that it is more nutritious. However, there is still considerable uncertainty over whether the use of organic production standards affects milk quality. Here we report results of meta-analyses based on 170 published studies comparing the nutrient content of organic and conventional bovine milk. There were no significant differences in total SFA and MUFA concentrations between organic and conventional milk. However, concentrations of total PUFA and n-3 PUFA were significantly higher in organic milk, by an estimated 7 (95 % CI -1, 15) % and 56 (95 % CI 38, 74) %, respectively...
March 28, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/26858145/conducting-omega-3-clinical-trials-with-cardiovascular-outcomes-proceedings-of-a-workshop-held-at-issfal-2014
#17
Harry B Rice, Aldo Bernasconi, Kevin C Maki, William S Harris, Clemens von Schacky, Philip C Calder
In contrast to earlier long-chain (LC) omega-3 (i.e. EPA and DHA) investigations, some recent studies have not demonstrated significant effects of EPA and DHA on cardiovascular disease (CVD) outcomes. The neutral findings may have been due to experimental design issues, such as: maintenance on aggressive cardiovascular drug treatment overshadowing the benefits of LC omega-3s, high background LC omega-3 intake, too few subjects in the study, treatment duration too short, insufficient LC omega-3 dosage, increase in omega-6 fatty acid intake during the study, failure to assess the LC omega-3 status of the subjects prior to and during treatment and lack of clarity concerning which mechanisms were expected to produce benefits...
April 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/26850746/omega-3-fatty-acids-do-not-alter-p-wave-parameters-in-electrocardiogram-or-expression-of-atrial-connexins-in-patients-undergoing-coronary-artery-bypass-surgery
#18
Palaniappan Saravanan, Annette L West, Ben Bridgewater, Neil C Davidson, Philip C Calder, Halina Dobrzynsky, Andrew Trafford, Stephen C O'Neill
AIMS: We previously reported omega-3 polyunsaturated fatty acids (n-3PUFAs) supplementation does not reduce atrial fibrillation (AF) following coronary artery bypass graft (CABG) surgery. The aim of the present study is to evaluate the impact of n-3 PUFAs on electrocardiogram (ECG) atrial arrhythmic markers and compare with expression of gap-junction proteins, Connexins. METHODS AND RESULTS: Subset of clinical trial subjects with right atrial sampling during CABG surgery included...
February 5, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/26817716/consumption-of-fish-oil-providing-amounts-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-that-can-be-obtained-from-the-diet-reduces-blood-pressure-in-adults-with-systolic-hypertension-a-retrospective-analysis
#19
RANDOMIZED CONTROLLED TRIAL
Anne M Minihane, Christopher K Armah, Elizabeth A Miles, Jacqueline M Madden, Allan B Clark, Muriel J Caslake, Chris J Packard, Bettina M Kofler, Georg Lietz, Peter J Curtis, John C Mathers, Christine M Williams, Philip C Calder
BACKGROUND: Although many randomized controlled trials (RCTs) have examined the effects of the n-3 (ω-3) fatty acids eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) on blood pressure (BP) and vascular function, the majority have used doses of EPA+DHA of >3 g/d, which are unlikely to be achieved by dietary manipulation. OBJECTIVE: The objective was to examine, by using a retrospective analysis from a multicenter RCT, the impact of recommended EPA+DHA intakes achievable through diet on systolic and diastolic BPs and microvascular function in adults in the United Kingdom...
March 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/26758374/effect-of-parenteral-infusion-of-fish-oil-based-lipid-emulsion-on-systemic-inflammatory-cytokines-and-lung-eicosanoid-levels-in-experimental-acute-pancreatitis
#20
Priscila Garla, Ricardo Garib, Raquel S Torrinhas, Marcel C C Machado, Philip C Calder, Dan L Waitzberg
: Parenteral fish oil lipid emulsion (FOLE) might mitigate inflammation after injury. Acute pancreatitis (AP) can occur following major surgery and is characterized by tissue and systemic release of inflammatory mediators that contributes to the systemic inflammatory response syndrome and multiple organ failure. AIM: We evaluated the effect of short-term FOLE infusion before experimental induction of AP on systemic cytokine and lung eicosanoid profiles. METHODS: Lewis rats (n = 72) received parenteral infusion of FOLE (FO group) or saline (SS group), or remained without parenteral infusion (CG group) for 48 h...
December 24, 2015: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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