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RA Montgomery

Matthias Englbrecht, Rieke Alten, Martin Aringer, Christoph G Baerwald, Harald Burkhardt, Nancy Eby, Gerhard Fliedner, Bettina Gauger, Ulf Henkemeier, Michael W Hofmann, Stefan Kleinert, Christian Kneitz, Klaus Krueger, Christoph Pohl, Anne-Eve Roske, Georg Schett, Marc Schmalzing, Anne-Kathrin Tausche, Hans Peter Tony, Joerg Wendler
OBJECTIVES: To validate standard self-reporting questionnaires for depression screening in patients with rheumatoid arthritis (RA) and compare these measures to each other and to the Montgomery-Åsberg Depression Rating Scale (MADRS), a standardized structured interview. METHODS: In 9 clinical centers across Germany, depressive symptomatology was assessed in 262 adult RA patients at baseline (T0) and at 12 ± 2 weeks follow-up (T1) using the WHO Five Well-Being Index (WHO-5), the Patient Health Questionnaire-9 (PHQ-9), and the Beck Depression Inventory (BDI-II)...
August 2, 2016: Arthritis Care & Research
Haijun Tian, Juanjuan Du, Jing Wen, Yang Liu, Scott R Montgomery, Trevor P Scott, Bayan Aghdasi, Chengjie Xiong, Akinobu Suzuki, Tetsuo Hayashi, Monchai Ruangchainikom, Kevin Phan, Gil Weintraub, Alobaidaan Raed, Samuel S Murray, Michael D Daubs, Xianjin Yang, Xu-Bo Yuan, Jeffrey C Wang, Yunfeng Lu
Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition...
August 23, 2016: ACS Nano
Ke Liu, Biji T Kurien, Sarah L Zimmerman, Kenneth M Kaufman, Diana H Taft, Leah C Kottyan, Sara Lazaro, Carrie A Weaver, John A Ice, Adam J Adler, James Chodosh, Lida Radfar, Astrid Rasmussen, Donald U Stone, David M Lewis, Shibo Li, Kristi A Koelsch, Ann Igoe, Mitali Talsania, Jay Kumar, Jacen S Maier-Moore, Valerie M Harris, Rajaram Gopalakrishnan, Roland Jonsson, James A Lessard, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Deborah S Cunninghame-Graham, Andrew J W Huang, Michael T Brennan, Pamela Hughes, Gabor G Illei, Corinne Miceli-Richard, Edward C Keystone, Vivian P Bykerk, Gideon Hirschfield, Gang Xie, Wan-Fai Ng, Gunnel Nordmark, Per Eriksson, Roald Omdal, Nelson L Rhodus, Maureen Rischmueller, Michael Rohrer, Barbara M Segal, Timothy J Vyse, Marie Wahren-Herlenius, Torsten Witte, Bernardo Pons-Estel, Marta E Alarcón-Riquelme, Joel M Guthridge, Judith A James, Christopher J Lessard, Jennifer A Kelly, Susan D Thompson, Patrick M Gaffney, Courtney G Montgomery, Jeffrey C Edberg, Robert P Kimberly, Graciela S Alarcón, Carl L Langefeld, Gary S Gilkeson, Diane L Kamen, Betty P Tsao, W Joseph McCune, Jane E Salmon, Joan T Merrill, Michael H Weisman, Daniel J Wallace, Tammy O Utset, Erwin P Bottinger, Christopher I Amos, Katherine A Siminovitch, Xavier Mariette, Kathy L Sivils, John B Harley, R Hal Scofield
OBJECTIVE: More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47,XXX; occurring in ∼1 in 1,000 live female births) would be increased in patients with female-predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], primary biliary cirrhosis, and rheumatoid arthritis [RA]) compared to patients with diseases without female predominance (sarcoidosis) and compared to controls...
May 2016: Arthritis & Rheumatology
Seong-Hye Hwang, Seung-Hyun Jung, Saseong Lee, Susanna Choi, Seung-Ah Yoo, Ji-Hwan Park, Daehee Hwang, Seung Cheol Shim, Laurent Sabbagh, Ki-Jo Kim, Sung Hwan Park, Chul-Soo Cho, Bong-Sung Kim, Lin Leng, Ruth R Montgomery, Richard Bucala, Yeun-Jun Chung, Wan-Uk Kim
Copy number variations (CNVs) have been implicated in human diseases. However, it remains unclear how they affect immune dysfunction and autoimmune diseases, including rheumatoid arthritis (RA). Here, we identified a novel leukocyte-specific protein 1 (LSP1) deletion variant for RA susceptibility located in 11p15.5. We replicated that the copy number of LSP1 gene is significantly lower in patients with RA, which correlates positively with LSP1 protein expression levels. Differentially expressed genes in Lsp1-deficient primary T cells represent cell motility and immune and cytokine responses...
November 24, 2015: Proceedings of the National Academy of Sciences of the United States of America
Anna B Montgomery, Jolanta Kopec, Leela Shrestha, Marie-Laetitia Thezenas, Nicola A Burgess-Brown, Roman Fischer, Wyatt W Yue, Patrick J Venables
BACKGROUND: Periodontitis (PD) is a known risk factor for rheumatoid arthritis (RA) and there is increasing evidence that the link between the two diseases is due to citrullination by the unique bacterial peptidylarginine deiminase (PAD) enzyme expressed by periodontal pathogen Pophyromonas gingivalis (PPAD). However, the precise mechanism by which PPAD could generate potentially immunogenic peptides has remained controversial due to lack of information about the structural and catalytic mechanisms of the enzyme...
June 2016: Annals of the Rheumatic Diseases
Elena B Lugli, Raquel E S M Correia, Roman Fischer, Karin Lundberg, Ken R Bracke, Anna B Montgomery, Benedikt M Kessler, Guy G Brusselle, Patrick J Venables
INTRODUCTION: Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic. To investigate this mechanism, we examined human lung tissue from 40 subjects with defined smoking status, with or without chronic obstructive pulmonary disease (COPD), and control tissues from other organs for citrullinated proteins and the deiminating enzymes peptidylarginine deiminase type-2 (PAD2) and -4 (PAD4)...
2015: Arthritis Research & Therapy
Semirra Bayan, Henry T Hoffman
IMPORTANCE: To our knowledge, we report the first series to analyze use of the Montgomery cannula as an airway management tool for indications other than obstructive sleep apnea. OBJECTIVES: To analyze the use and outcomes of Montgomery cannula placement for airway management and to identify indications for placement. DESIGN, SETTING, AND PARTICIPANTS: Retrospective review of 20 patients who received a Montgomery cannula from 2003 through 2012 at the University of Iowa Hospitals and Clinics...
February 2015: JAMA Otolaryngology—Head & Neck Surgery
Haijun Tian, Chen-Shuang Li, Trevor P Scott, Scott R Montgomery, Kevin Phan, Lifeng Lao, Wei Zhang, Yawei Li, Tetsuo Hayashi, Shinji Takahashi, Raed Alobaidaan, Monchai Ruangchainikom, Ke-Wei Zhao, Elsa J Brochmann, Samuel S Murray, Jeffrey C Wang, Michael D Daubs
BACKGROUND CONTEXT: Bone morphogenetic protein-2 (BMP-2) has been used to successfully promote spine fusion, but side-effects including nerve inflammation have been observed. PURPOSE: To investigate the direct neurotoxic effects of BMP-2 and test the hypotheses that the use of BMP binding proteins, such as secreted phosphoprotein 24 kD (Spp24), can reduce or eliminate these effects. STUDY DESIGN: In vitro experiments and in vivo analysis in a rodent model...
February 1, 2015: Spine Journal: Official Journal of the North American Spine Society
Scott R Montgomery, Taya Nargizyan, Vicente Meliton, Sigrid Nachtergaele, Rajat Rohatgi, Frank Stappenbeck, Michael E Jung, Jared S Johnson, Bayan Aghdasi, Haijun Tian, Gil Weintraub, Hirokazu Inoue, Elisa Atti, Sotirios Tetradis, Renata C Pereira, Akishige Hokugo, Raed Alobaidaan, Yanlin Tan, Theodor J Hahn, Jeffrey C Wang, Farhad Parhami
Osteogenic factors are often used in orthopedics to promote bone growth, improve fracture healing, and induce spine fusion. Osteogenic oxysterols are naturally occurring molecules that were shown to induce osteogenic differentiation in vitro and promote spine fusion in vivo. The purpose of this study was to identify an osteogenic oxysterol more suitable for clinical development than those previously reported, and evaluate its ability to promote osteogenesis in vitro and spine fusion in rats in vivo. Among more than 100 oxysterol analogues synthesized, Oxy133 induced significant expression of osteogenic markers Runx2, osterix (OSX), alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteocalcin (OCN) in C3H10T1/2 mouse embryonic fibroblasts and in M2-10B4 mouse marrow stromal cells...
August 2014: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Anna B Montgomery, Patrick J Venables, Benjamin A Fisher
Anti-citrullinated protein/peptide antibodies (ACPA) are the principal autoantibody system associated with rheumatoid arthritis (RA), with diagnostic sensitivity of 70% and specificity of 95%. Current testing for ACPA uses the anti-cyclic citrullinated peptide assay (anti-CCP) which measures a generalized reactivity with citrulline-containing peptides, thus giving no insight into reactivity to specific RA antigens. Of these, the best characterized are, α-enolase, fibrinogen/fibrin, vimentin, Type 2 collagen and filaggrin, antibodies to each of which are found in approximately 30-60% of RA cases...
December 2013: Expert Review of Clinical Immunology
Konrad J Karczewski, Joel T Dudley, Kimberly R Kukurba, Rong Chen, Atul J Butte, Stephen B Montgomery, Michael Snyder
Genome-wide association studies have discovered many genetic loci associated with disease traits, but the functional molecular basis of these associations is often unresolved. Genome-wide regulatory and gene expression profiles measured across individuals and diseases reflect downstream effects of genetic variation and may allow for functional assessment of disease-associated loci. Here, we present a unique approach for systematic integration of genetic disease associations, transcription factor binding among individuals, and gene expression data to assess the functional consequences of variants associated with hundreds of human diseases...
June 4, 2013: Proceedings of the National Academy of Sciences of the United States of America
Joel M Montgomery, Patrick J Blair, Darin S Carroll, James N Mills, Alberto Gianella, Naomi Iihoshi, Ana M Briggiler, Vidal Felices, Milagros Salazar, James G Olson, Raisa A Glabman, Daniel G Bausch
We report the results of an investigation of a small outbreak of hantavirus pulmonary syndrome in 2002 in the Department of Santa Cruz, Bolivia, where the disease had not previously been reported. Two cases were initially reported. The first case was a physician infected with Laguna Negra virus during a weekend visit to his ranch. Four other persons living on the ranch were IgM antibody-positive, two of whom were symptomatic for mild hantavirus pulmonary syndrome. The second case was a migrant sugarcane worker...
2012: PLoS Neglected Tropical Diseases
Karin J H Verweij, Jian Yang, Jari Lahti, Juha Veijola, Mirka Hintsanen, Laura Pulkki-Råback, Kati Heinonen, Anneli Pouta, Anu-Katriina Pesonen, Elisabeth Widen, Anja Taanila, Matti Isohanni, Jouko Miettunen, Aarno Palotie, Lars Penke, Susan K Service, Andrew C Heath, Grant W Montgomery, Olli Raitakari, Mika Kähönen, Jorma Viikari, Katri Räikkönen, Johan G Eriksson, Liisa Keltikangas-Järvinen, Terho Lehtimäki, Nicholas G Martin, Marjo-Riitta Järvelin, Peter M Visscher, Matthew C Keller, Brendan P Zietsch
Personality traits are basic dimensions of behavioral variation, and twin, family, and adoption studies show that around 30% of the between-individual variation is due to genetic variation. There is rapidly growing interest in understanding the evolutionary basis of this genetic variation. Several evolutionary mechanisms could explain how genetic variation is maintained in traits, and each of these makes predictions in terms of the relative contribution of rare and common genetic variants to personality variation, the magnitude of nonadditive genetic influences, and whether personality is affected by inbreeding...
October 2012: Evolution; International Journal of Organic Evolution
Petya Terziivanova, Svetlozar Haralanov
RATIONALE, AIMS AND OBJECTIVES: Psychomotor disturbances have been regarded as cardinal symptoms of depression for centuries and their objective assessment may have predictive value with respect to the severity of clinical depression, treatment outcome and prognosis of the affective disorder. METHODS: Montgomery-Åsberg Depression Rating Scale (MADRS) and Hamilton Rating Scale for Anxiety (HAM-A). Psychomotor indicators of activity and reactivity were objectively recorded and measured by means of computerized ultrasonographic craniocorpography...
December 2012: Journal of Evaluation in Clinical Practice
C M Middeldorp, M H M de Moor, L M McGrath, S D Gordon, D H Blackwood, P T Costa, A Terracciano, R F Krueger, E J C de Geus, D R Nyholt, T Tanaka, T Esko, P A F Madden, J Derringer, N Amin, G Willemsen, J-J Hottenga, M A Distel, M Uda, S Sanna, P Spinhoven, C A Hartman, S Ripke, P F Sullivan, A Realo, J Allik, A C Heath, M L Pergadia, A Agrawal, P Lin, R A Grucza, E Widen, D L Cousminer, J G Eriksson, A Palotie, J H Barnett, P H Lee, M Luciano, A Tenesa, G Davies, L M Lopez, N K Hansell, S E Medland, L Ferrucci, D Schlessinger, G W Montgomery, M J Wright, Y S Aulchenko, A C J W Janssens, B A Oostra, A Metspalu, G R Abecasis, I J Deary, K Räikkönen, L J Bierut, N G Martin, N R Wray, C M van Duijn, J W Smoller, B W J H Penninx, D I Boomsma
The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, whereas openness to experience is specific for BD. This study examined the genetic association between personality and MDD and BD by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders...
2011: Translational Psychiatry
A Terracciano, T Esko, A R Sutin, M H M de Moor, O Meirelles, G Zhu, T Tanaka, I Giegling, T Nutile, A Realo, J Allik, N K Hansell, M J Wright, G W Montgomery, G Willemsen, J-J Hottenga, M Friedl, D Ruggiero, R Sorice, S Sanna, A Cannas, K Räikkönen, E Widen, A Palotie, J G Eriksson, F Cucca, R F Krueger, J Lahti, M Luciano, J W Smoller, C M van Duijn, G R Abecasis, D I Boomsma, M Ciullo, P T Costa, L Ferrucci, N G Martin, A Metspalu, D Rujescu, D Schlessinger, M Uda
The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures of excitement-seeking are more likely to smoke, use other drugs, gamble, drive recklessly, have unsafe/unprotected sex and engage in other risky behaviors of clinical and social relevance. To identify common genetic variants associated with the Excitement-Seeking scale of the Revised NEO Personality Inventory, we performed genome-wide association studies in six samples of European ancestry (N=7860), and combined the results in a meta-analysis...
2011: Translational Psychiatry
S K Service, K J H Verweij, J Lahti, E Congdon, J Ekelund, M Hintsanen, K Räikkönen, T Lehtimäki, M Kähönen, E Widen, A Taanila, J Veijola, A C Heath, P A F Madden, G W Montgomery, C Sabatti, M-R Järvelin, A Palotie, O Raitakari, J Viikari, N G Martin, J G Eriksson, L Keltikangas-Järvinen, N R Wray, N B Freimer
Temperament has a strongly heritable component, yet multiple independent genome-wide studies have failed to identify significant genetic associations. We have assembled the largest sample to date of persons with genome-wide genotype data, who have been assessed with Cloninger's Temperament and Character Inventory. Sum scores for novelty seeking, harm avoidance, reward dependence and persistence have been measured in over 11,000 persons collected in four different cohorts. Our study had >80% power to identify genome-wide significant loci (P<1...
2012: Translational Psychiatry
Christina A Arnold, Roger K Moreira, Dora Lam-Himlin, Giovanni De Petris, Elizabeth Montgomery
Although Whipple disease was described over a century ago, it remains challenging to recognize. To better understand the presentation of Whipple disease, we undertook a clinicopathologic study of our experience since implementation of the Whipple immunohistochemical stain. Twenty-three biopsy specimens from 15 patients were identified, and an association with immunomodulatory conditions was noted. Whipple disease involved the small intestine (19), brain (2), breast (1), and retroperitoneum (1). Whipple disease was suspected by 3 clinicians and by the majority of pathologists (9)...
July 2012: American Journal of Surgical Pathology
John A Ice, He Li, Indra Adrianto, Paul Chee Lin, Jennifer A Kelly, Courtney G Montgomery, Christopher J Lessard, Kathy L Moser
While Sjögren's syndrome (SS) is more common than related autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), scientific and medical research in SS has lagged behind significantly. This is especially true in the field of SS genetics, where efforts to date have relied heavily on candidate gene approaches. Within the last decade, the advent of the genome-wide association (GWA) scan has altered our understanding of disease pathogenesis in hundreds of disorders through the successful identification of novel risk loci...
August 2012: Journal of Autoimmunity
Rawdha Tekaya, Faten Saadi, Ines Mahmoud, Olfa Saidane, Leila Abdelmoula, Lilia Chaabouni, Rafik Zouari
OBJECTIVE: To assess the prevalence of depression in a series of Tunisian patients with rheumatoid arthritis (RA) and to identify factors associated with its occurrence. METHODS: We performed a cross sectional study on 60 patients with RA. The evaluation of depression was performed using the Montgomery and Asberg depression rating scale. RESULTS: Our study revealed a high prevalence of depression in RA patients (45%). The main predictor factors of its occurrence were female gender, absence of professional activity, absence of social support, high activity of RA, impaired quality of life and existence of structural damage...
May 2012: La Presse Médicale
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