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Sanne Enok, Gabriella S P C Leite, Cléo A C Leite, Hans Gesser, Michael S Hedrick, Tobias Wang
To accommodate the pronounced metabolic response to digestion, pythons increase heart rate and elevate stroke volume, where the latter has been ascribed to a massive and fast cardiac hypertrophy. However, numerous recent studies show that heart mass rarely increases, even upon ingestion of large meals, and we therefore explored the possibility that a rise in mean circulatory filling pressure (MCFP) serves to elevate venous pressure and cardiac filling during digestion. To this end, we measured blood flows and pressures in anaesthetized Python regius The anaesthetized snakes exhibited the archetypal tachycardia as well as a rise in both venous pressure and MCFP that fully account for the approximate doubling of stroke volume...
October 1, 2016: Journal of Experimental Biology
Dusty Rose Miller, Saurabh Das, Kuo-Ying Huang, Songi Han, Jacob N Israelachvili, J Herbert Waite
The role of friction in the functional performance of biomaterial interfaces is widely reckoned to be critical and complicated but poorly understood. To better understand friction forces, we investigated the natural adaptation of the holdfast or byssus of mussels that live in high-energy surf habitats. As the outermost covering of the byssus, the cuticle deserves particular attention for its adaptations to frictional wear under shear. In this study, we coacervated one of three variants of a key cuticular component, mussel foot protein 1, mfp-1 [(1) Mytilus californianus mcfp-1, (2) rmfp-1, and (3) rmfp-1-Dopa], with hyaluronic acid (HA) and investigated the wear protection capabilities of these coacervates to surfaces (mica) during shear...
November 9, 2015: ACS Biomaterials Science & Engineering
Darwin Babino, Brian D Perkins, Aljoscha Kindermann, Vitus Oberhauser, Johannes von Lintig
A cycle of cis-to-trans isomerization of the chromophore is intrinsic to vertebrate vision where rod and cone photoreceptors mediate dim- and bright-light vision, respectively. Daylight illumination can greatly exceed the rate at which the photoproduct can be recycled back to the chromophore by the canonical visual cycle. Thus, an additional supply pathway(s) must exist to sustain cone-dependent vision. Two-photon microscopy revealed that the eyes of the zebrafish (Danio rerio) contain high levels of 11-cis-retinyl esters (11-REs) within the retinal pigment epithelium...
January 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Dominic E Fullenkamp, Devin G Barrett, Dusty R Miller, Josh W Kurutz, Phillip B Messersmith
The mussel byssus is a remarkable attachment structure that is formed by injection molding and rapid in-situ hardening of concentrated solutions of proteins enriched in the catecholic amino acid 3,4-dihydroxy-L-phenylalanine (DOPA). Fe(3+), found in high concentrations in the byssus, has been speculated to participate in redox reactions with DOPA that lead to protein polymerization, however direct evidence to support this hypothesis has been lacking. Using small molecule catechols, DOPA-containing peptides, and native mussel foot proteins, we report the first direct observation of catechol oxidation and polymerization accompanied by reduction of Fe(3+) to Fe(2+)...
2014: RSC Advances
Joanne Y T Leung, Catherine C Y Pang, Ric M Procyshyn, Alasdair M Barr
Treatment with antipsychotics is associated with adverse cardiovascular effects such as orthostatic hypotension and arrhythmias. Despite the higher prevalence of cardiovascular complications in patients with schizophrenia, the effects of antipsychotic drugs on vascular tone and cardiac contractility have received little attention. In order to better understand the cardiovascular effects of antipsychotic drugs, we investigated if the atypical antipsychotic olanzapine alters in vivo cardiovascular function in rats...
September 2014: Vascular Pharmacology
J T Sohn, S Hoka, K Yamaura, S Takahashi
The purpose of this study was to examine the effects of nicardipine and sodium nitroprusside (SNP) on vascular capacitance in the rat. In ten rats anesthetized with pentobarbital, mean arterial pressure was lowered to about 70 mmHg and subsequently 50 mmHg by intravenous infusion of nicardipine or SNP. Vascular capacitance was assessed before and during nicardipine- or SNP-induced hypotension by measuring the mean circulatory filling pressure (MCFP). MCFP was measured during a brief period of circulatory arrest produced by inflating a balloon inserted in the right atrium...
September 1996: Journal of Anesthesia
Carole J Saade, Karen Alvarez-Delfin, James M Fadool
Humans are largely dependent upon cone-mediated vision. However, death or dysfunction of rods, the predominant photoreceptor subtype, results in secondary loss of cones, remodeling of retinal circuitry, and blindness. The changes in circuitry may contribute to the vision deficit and undermine attempts at restoring sight. We exploit zebrafish larvae as a genetic model to specifically characterize changes associated with photoreceptor degenerations in a cone-dominated retina. Photoreceptors form synapses with two types of second-order neurons, bipolar cells, and horizontal cells...
January 30, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Michelle Ramsey, Brian D Perkins
The asymmetric positioning of basal bodies, and therefore cilia, is often critical for proper cilia function. This planar polarity is critical for motile cilia function but has not been extensively investigated for nonmotile cilia or for sensory cilia such as vertebrate photoreceptors. Zebrafish photoreceptors form an organized mosaic ideal for investigating cilia positioning. We report that, in the adult retina, the basal bodies of red-, green-, and blue-sensitive cone photoreceptors localized asymmetrically on the cell edge nearest the optic nerve...
June 1, 2013: Journal of Comparative Neurology
Dong Soo Hwang, Matthew J Harrington, Qingye Lu, Admir Masic, Hongbo Zeng, J Herbert Waite
Marine mussels utilize a variety of DOPA-rich proteins for purposes of underwater adhesion, as well as for creating hard and flexible surface coatings for their tough and stretchy byssal fibers. In the present study, moderately strong, yet reversible wet adhesion between the protective mussel coating protein, mcfp-1, and amorphous titania was measured with a surface force apparatus (SFA). In parallel, resonance Raman spectroscopy was employed to identify the presence of bidentate DOPA-Ti coordination bonds at the TiO(2)-protein interface, suggesting that catechol-TiO(2) complexation contributes to the observed reversible wet adhesion...
August 21, 2012: Journal of Materials Chemistry
Ammar Abdo, Ségolène Caboche, Valérie Leclère, Philippe Jacques, Maude Pupin
Bacteria and fungi use a set of enzymes called nonribosomal peptide synthetases to provide a wide range of natural peptides displaying structural and biological diversity. So, nonribosomal peptides (NRPs) are the basis for some efficient drugs. While discovering new NRPs is very desirable, the process of identifying their biological activity to be used as drugs is a challenge. In this paper, we present a novel peptide fingerprint based on monomer composition (MCFP) of NRPs. MCFP is a novel method for obtaining a representative description of NRP structures from their monomer composition in fingerprint form...
October 2012: Journal of Computer-aided Molecular Design
Ruslan Tiniakov, Kalipada Pahan, Karie E Scrogin
Administration of the 5-HT(1A) receptor agonist, 8-OH-DPAT, improves cardiovascular hemodynamics and tissue oxygenation in conscious rats subjected to hypovolemic shock. This effect is mediated by sympathetic-dependent increases in venous tone. To determine the role of splanchnic nerves in this response, effects of 8-OH-DPAT (30 nmol/kg iv) were measured following fixed-arterial blood pressure hemorrhagic shock (i.e., maintenance of 50 mmHg arterial pressure for 25 min) in rats subjected to bilateral splanchnic nerve denervation (SD)...
September 1, 2012: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Qingye Lu, Dong Soo Hwang, Yang Liu, Hongbo Zeng
Protective coating of the byssus of mussels (Mytilus sp.) has been suggested as a new paradigm of medical coating due to its high extensibility and hardness co-existence without their mutual detriment. The only known biomacromolecule in the extensible and tough coating on the byssus is mussel foot protein-1 (mfp-1), which is made up with positively charged residues (~20 mol%) and lack of negatively charged residues. Here, adhesion and molecular interaction mechanisms of Mytilus californianus foot protein-1 (mcfp-1) from California blue mussel were investigated using a surface forces apparatus (SFA) in buffer solutions of different ionic concentrations (0...
February 2012: Biomaterials
Hisanobu Yonezawa, Souichi Yanamoto, Goro Kawasaki, Masahiro Umeda
No abstract text is available yet for this article.
April 2012: British Journal of Oral & Maxillofacial Surgery
Hisanobu Yonezawa, Shin-ichi Yamada, Souichi Yanamoto, Izumi Yoshitomi, Goro Kawasaki, Masahiro Umeda
The aim of this study was to examine the effectiveness of covering wounds to the tongue with a polyglycolic acid (PGA) sheet and fibrin glue. Eighteen mature male Japanese white rabbits had a unilateral glossectomy involving an area 10mm×10mm×2mm. After glossectomy the tongues were covered with PGA sheets 8mm×8mm in size and fibrin glue (mucosal defect covered with fibrin glue and polyglycolic acid sheet=MCFP) 1 week after the operation (n=3), after 2 weeks (n=3), and after 4 weeks (n=3). In control groups, after 1, 2, and 4 weeks (n=3 in each group), the partially resected tongues were closed with absorbable sutures (polyglactin 910)...
July 2012: British Journal of Oral & Maxillofacial Surgery
Ann C Morris, Marie A Forbes-Osborne, Lakshmi S Pillai, James M Fadool
PURPOSE: XOPS-mCFP transgenic zebrafish experience a continual cycle of rod photoreceptor development and degeneration throughout life, making them a useful model for investigating the molecular determinants of rod photoreceptor regeneration. The purpose of this study was to compare the gene expression profiles of wild-type and XOPS-mCFP retinas and identify genes that may contribute to the regeneration of the rods. METHODS: Adult wild-type and XOPS-mCFP retinal mRNA was subjected to microarray analysis...
April 2011: Investigative Ophthalmology & Visual Science
Julia E Herrmann, Morgan A Pence, Emanuel A Shapera, Ravi R Shah, Cédric G Geoffroy, Binhai Zheng
Ephrins and Eph receptor tyrosine kinases are cell-surface molecules that serve a multitude of functions in cell-cell communication in development, physiology, and disease. EphA4 is a promiscuous member of the EphA subclass of Eph receptors and can bind to both EphrinAs and EphrinBs. In addition to its well-established roles in guiding the development of neuronal connectivity, EphA4 has been implicated for a role in synaptic plasticity, vascular formation, axon regeneration, and central nervous system repair following injury...
February 2010: Genesis: the Journal of Genetics and Development
U Janssens, J Graf
Values of intramural or even transmural central venous pressure (CVP) as well as values of pulmonary artery occluded pressure do not correlate with the values of measured circulating blood volume or with responsiveness to fluid challenge. The veins contain approximately 70% of the total blood volume and are 30 times more compliant than arteries, therefore, changes in blood volume within the veins are associated with relatively small changes in venous pressure. The main reason for a lack of correlation between CVP values and blood volume is that the body does everything possible to maintain homeostasis and adequate transmural CVP is a must for cardiovascular function...
May 2009: Der Anaesthesist
Ruslan Tiniakov, Karie E Scrogin
The 5-HT(1A) receptor agonist, 8- OH-DPAT, increases whole body venous tone (mean circulatory filling pressure; MCFP), and attenuates metabolic acidosis in a rat model of unresuscitated hemorrhagic shock. To determine whether improved acid-base balance was associated with sympathetic activation and venous constriction, MCFP, sympathetic activity (SA), and blood gases were compared in hemorrhaged rats following administration of 5-HT(1A) receptor agonist 8-OH-DPAT, the arterial vasoconstrictor arginine vasopressin (AVP), or saline...
May 2009: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Niels Holten-Andersen, Hua Zhao, J Herbert Waite
For lasting holdfast attachment, the mussel Mytilus californianus coats its byssal threads with a protective cuticle 2-5 microm thick that is 4-6 times stiffer than the underlying collagen fibers. Although cuticle hardness (0.1 GPa) and stiffness (2 GPa) resemble those observed in related mussels, a more effective dispersion of microdamage enables M. californianus byssal threads to sustain strains to almost 120% before cuticle rupture occurs. Underlying factors for the superior damage tolerance of the byssal cuticle were explored in its microarchitecture and in the cuticular protein, mcfp-1...
March 31, 2009: Biochemistry
Enric Zelazny, Urszula Miecielica, Jan Willem Borst, Marcus A Hemminga, François Chaumont
Maize plasma membrane aquaporins (ZmPIPs, where PIP is the plasma membrane intrinsic protein) fall into two groups, ZmPIP1s and ZmPIP2s, which, when expressed alone in mesophyll protoplasts, are found in different subcellular locations. Whereas ZmPIP1s are retained in the endoplasmic reticulum (ER), ZmPIP2s are found in the plasma membrane (PM). We previously showed that, when co-expressed with ZmPIP2s, ZmPIP1s are relocalized to the PM, and that this relocalization results from the formation of hetero-oligomers between ZmPIP1s and ZmPIP2s...
January 2009: Plant Journal: for Cell and Molecular Biology
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