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https://www.readbyqxmd.com/read/27890833/pulse-wave-analysis-after-treatment-of-abdominal-aortic-aneurysms-with-the-ovation-device
#1
Efstratios Georgakarakos, Christos Argyriou, George S Georgiadis, Miltos K Lazarides
BACKGROUND: Ovation Aortic Stent-Graft System is a new device for the endovascular treatment of Abdominal Aortic Aneurysms achieving fixation via a 35-mm long, rigid ancored suprarenal stent and sealing stent at the infrarenal level by a means of a polymer-filling pair of inflatable O-rings which cause narrowing of flow lumen and regional stenosis. Thus, concerns have been raised regarding hemodynamic consequences associated with this new desing . Our preliminary report showed no significant increase of aortic pulse wave velocity (aPWV) immediately after implantation of the Ovation in 3 patients...
November 24, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27783382/short-term-effects-of-neuromuscular-blockade-on-global-and-regional-lung-mechanics-oxygenation-and-ventilation-in-pediatric-acute-hypoxemic-respiratory-failure
#2
Marlon E F Wilsterman, Pauline de Jager, Robert Blokpoel, Inez Frerichs, Sandra K Dijkstra, Marcel J I J Albers, Johannes G M Burgerhof, Dick G Markhorst, Martin C J Kneyber
BACKGROUND: Neuromuscular blockade (NMB) has been shown to improve outcome in acute respiratory distress syndrome (ARDS) in adults, challenging maintaining spontaneous breathing when there is severe lung injury. We tested in a prospective physiological study the hypothesis that continuous administration of NMB agents in mechanically ventilated children with severe acute hypoxemic respiratory failure (AHRF) improves the oxygenation index without a redistribution of tidal volume V T toward non-dependent lung zones...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27768204/in-vitro-performance-investigation-of-syncardia%C3%A2-freedom%C3%A2-driver-via-patient-simulator-mock-loop
#3
Riccardo Toninato, Silvia Scuri, Vincenzo Tarzia, Gino Gerosa, Francesca M Susin
PURPOSE: The gold standard therapy for patients with advanced heart failure is heart transplant. The gap between donors and patients in waiting lists promoted the development of circulatory support devices, such as the total artificial heart (TAH). Focusing on in vitro tests performed with CardioWest™ TAH (CW) driven by the SynCardia Freedom® portable driver (FD) the present study goals are: i) prove the reliability of a hydraulic circuit used as patient simulator to replicate a quasi-physiological scenario for various hydrodynamic conditions, ii) investigate the hydrodynamic performance of the CW FD, iii) help clinicians in possible interpretation of clinical cases outcomes...
November 29, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27754185/hw-02-3-ambulatory-central-blood-pressure-what-is-the-evidence-for-validation
#4
Thomas Weber
Validation of a medical device measuring a biomarker is a complex process, involving technical aspects (What is actually measured by the device, and how is this done ? Is the measurement reproducible ? Is there a gold standard for measurement of the particular biomarker ? If yes, how accurate and how precise are the measurements by the device, compared to the gold standard ?) and clinical aspects (Do the measurements predict outcome ? If yes, is there added value, when standard clinical parameters are considered ? Is there a treatment strategy, based on the mesurements of the novel device ? Is this strategy cost-effective ?)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754089/os-20-03-the-associations-between-each-component-of-blood-pressure-and-target-organ-damages-in-patients-at-high-risk-of-coronary-artery-disease
#5
Hack-Lyoung Kim, Myung-A Kim, Wan-Joo Shim, Mina Kim, Seong Mi Park, Mi Seung Shin, Kyung-Soon Hong, Yong Hyun Kim, Hyun Ju Yoon, Gil Ja Shin, Kyoung Im Cho
OBJECTIVE: Data from systemic evaluation of the influence of each component of blood pressure (BP) on various target organ damages (TODs) has been limited. This study was performed to elucidate which BP component was associated with TODs in patients with high risk of coronary artery disease (CAD). DESIGN AND METHOD: Study data were obtained from a nation-wide registry, composed of 652 patiens (471 women with 58.4 ± 10.5 year old) with suspected CAD who underwent invasive coronary angiography (CAG)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643142/hw-02-3-ambulatory-central-blood-pressure-what-is-the-evidence-for-validation
#6
Thomas Weber
Validation of a medical device measuring a biomarker is a complex process, involving technical aspects (What is actually measured by the device, and how is this done ? Is the measurement reproducible ? Is there a gold standard for measurement of the particular biomarker ? If yes, how accurate and how precise are the measurements by the device, compared to the gold standard ?) and clinical aspects (Do the measurements predict outcome ? If yes, is there added value, when standard clinical parameters are considered ? Is there a treatment strategy, based on the mesurements of the novel device ? Is this strategy cost-effective ?)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643014/os-20-03-the-associations-between-each-component-of-blood-pressure-and-target-organ-damages-in-patients-at-high-risk-of-coronary-artery-disease
#7
Hack-Lyoung Kim, Myung-A Kim, Wan-Joo Shim, Mina Kim, Seong Mi Park, Mi Seung Shin, Kyung-Soon Hong, Yong Hyun Kim, Hyun Ju Yoon, Gil Ja Shin, Kyoung Im Cho
OBJECTIVE: Data from systemic evaluation of the influence of each component of blood pressure (BP) on various target organ damages (TODs) has been limited. This study was performed to elucidate which BP component was associated with TODs in patients with high risk of coronary artery disease (CAD). DESIGN AND METHOD: Study data were obtained from a nation-wide registry, composed of 652 patiens (471 women with 58.4 ± 10.5 year old) with suspected CAD who underwent invasive coronary angiography (CAG)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27638238/physiologic-determinants-of-left-atrial-longitudinal-strain-a-two-dimensional-speckle-tracking-and%C3%A2-three-dimensional-echocardiographic-study%C3%A2-in-healthy-volunteers
#8
Marcelo Haertel Miglioranza, Luigi Paolo Badano, Sorina Mihăilă, Diletta Peluso, Umberto Cucchini, Nicola Soriani, Sabino Iliceto, Denisa Muraru
BACKGROUND: Left atrial (LA) longitudinal strain (LS) using two-dimensional speckle-tracking echocardiography has emerged as an important diagnostic and prognostic parameter in various cardiovascular conditions. However, its reference values, their correlations with demographics characteristics, and its physiologic determinants remain to be established. METHODS: Accordingly, 171 healthy volunteers (mean age, 45 ± 12 years; 61% women) in whom LS was obtained from both apical four- and two-chamber dedicated views of the left atrium, considering the P-P interval on the electrocardiogram as the reference cardiac cycle, were prospectively studied...
September 13, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27580225/one-step-generation-of-cell-encapsulating-compartments-via-polyelectrolyte-complexation-in-an-aqueous-two-phase-system
#9
Sarah D Hann, Tagbo H R Niepa, Kathleen J Stebe, Daeyeon Lee
Diverse fields including drug and gene delivery and live cell encapsulation require biologically compatible encapsulation systems. One widely adopted means of forming capsules exploits cargo-filled microdroplets in an external, immiscible liquid phase that are encapsulated by a membrane that forms by trapping of molecules or particles at the drop surface, facilitated by the interfacial tension. To eliminate the potentially deleterious oil phase often present in such processes, we exploit the aqueous two phase system of poly(ethylene glycol) (PEG) and dextran...
September 28, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27568347/the-use-of-the-oesophageal-doppler-in-perioperative-medicine-new-opportunities-in-research-and-clinical-practice
#10
Bernardo Bollen Pinto, Glen Atlas, Bart F Geerts, Karim Bendjelid
The oesophageal Doppler (OD) is a minimally invasive haemodynamic monitor used in the surgical theatre and the ICU. Using the OD, goal-directed therapy (GDT) has been shown to reduce perioperative complications in high-risk surgical patients. However, most GDT protocols currently in use are limited to stroke volume optimisation. In the present manuscript, we examine the conceptual models behind new OD-based measurements. These would provide the clinician with a comprehensive view of haemodynamic pathophysiology; including pre-load, contractility, and afterload...
August 27, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27520434/hysteretic-behavior-of-bladder-afferent-neurons-in-response-to-changes-in-bladder-pressure
#11
Shani E Ross, Zachariah J Sperry, Colin M Mahar, Tim M Bruns
BACKGROUND: Mechanosensitive afferents innervating the bladder increase their firing rate as the bladder fills and pressure rises. However, the relationship between afferent firing rates and intravesical pressure is not a simple linear one. Firing rate responses to pressure can differ depending on prior activity, demonstrating hysteresis in the system. Though this hysteresis has been commented on in published literature, it has not been quantified. RESULTS: Sixty-six bladder afferents recorded from sacral dorsal root ganglia in five alpha-chloralose anesthetized felines were identified based on their characteristic responses to pressure (correlation coefficient ≥ 0...
2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27515195/a-unifying-hypothesis-for-hydrocephalus-and-the-chiari-malformations-part-two-the-hydrocephalus-filling-mechanism
#12
Helen Williams
It is proposed that negative central nervous system (CNS) pressure is one of the filling mechanisms of the fluid spaces of the CNS. Negative CNS pressure is caused by the combination of gravitational force and body movement. The venous system imposes pressure fluctuations on the CNS due to changes in posture and body cavity pressure. It is proposed here that filling of veins, arteries and cerebrospinal (CSF) spaces are all assisted by negative CNS pressure. Hyperemia in the CNS in response to pressure changes with movement was described in the first part of this hypothesis...
September 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27513561/hydrodynamic-trapping-for-rapid-assembly-and-in-situ-electrical-characterization-of-droplet-interface-bilayer-arrays
#13
Mary-Anne Nguyen, Bernadeta Srijanto, C Patrick Collier, Scott T Retterer, Stephen A Sarles
The droplet interface bilayer (DIB) is a modular technique for assembling planar lipid membranes between water droplets in oil. The DIB method thus provides a unique capability for developing digital, droplet-based membrane platforms for rapid membrane characterization, drug screening and ion channel recordings. This paper demonstrates a new, low-volume microfluidic system that automates droplet generation, sorting, and sequential trapping in designated locations to enable the rapid assembly of arrays of DIBs...
September 21, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27458234/inhaled-sodium-nitrite-improves-rest-and-exercise-hemodynamics-in-heart-failure-with-preserved-ejection-fraction
#14
Barry A Borlaug, Vojtech Melenovsky, Katlyn E Koepp
RATIONALE: Abnormalities in nitric oxide signaling play a pivotal role in heart failure with preserved ejection fraction (HFpEF). Intravenous sodium nitrite, which is converted to nitric oxide in vivo, improves hemodynamics in HFpEF, but its use is limited by the need for parenteral administration. Nitrite can also be administered using a novel, portable micronebulizer system suitable for chronic use. OBJECTIVE: Determine whether inhaled nitrite improves hemodynamics in HFpEF...
September 16, 2016: Circulation Research
https://www.readbyqxmd.com/read/27422991/effect-of-peep-blood-volume-and-inspiratory-hold-maneuvers-on-venous-return
#15
David Berger, Per W Moller, Alberto Weber, Andreas Bloch, Stefan Bloechlinger, Matthias Haenggi, Soren Sondergaard, Stephan M Jakob, Sheldon Magder, Jukka Takala
According to Guyton's model of circulation, mean systemic filling pressure (MSFP), right atrial pressure (RAP), and resistance to venous return (RVR) determine venous return. MSFP has been estimated from inspiratory hold-induced changes in RAP and blood flow. We studied the effect of positive end-expiratory pressure (PEEP) and blood volume on venous return and MSFP in pigs. MSFP was measured by balloon occlusion of the right atrium (MSFPRAO), and the MSFP obtained via extrapolation of pressure-flow relationships with airway occlusion (MSFPinsp_hold) was extrapolated from RAP/pulmonary artery flow (QPA) relationships during inspiratory holds at PEEP 5 and 10 cmH2O, after bleeding, and in hypervolemia...
September 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27419825/novel-method-for-dynamic-control-of-intracranial-pressure
#16
Mark G Luciano, Stephen M Dombrowski, Sara Qvarlander, Serge El-Khoury, Jun Yang, Suraj Thyagaraj, Francis Loth
OBJECT Intracranial pressure (ICP) pulsations are generally considered a passive result of the pulsatility of blood flow. Active experimental modification of ICP pulsations would allow investigation of potential active effects on blood and CSF flow and potentially create a new platform for the treatment of acute and chronic low blood flow states as well as a method of CSF substance clearance and delivery. This study presents a novel method and device for altering the ICP waveform via cardiac-gated volume changes...
July 15, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27368695/exercise-echocardiography-for-the-assessment-of-pulmonary-hypertension-in-systemic-sclerosis-a-systematic-review
#17
Rui Baptista, Sara Serra, Rui Martins, Rogério Teixeira, Graça Castro, Maria João Salvador, José António Pereira da Silva, Lèlita Santos, Pedro Monteiro, Mariano Pêgo
BACKGROUND: Pulmonary arterial hypertension (PAH) complicates the course of systemic sclerosis (SSc) and is associated with poor prognosis. The elevation of systolic pulmonary arterial pressure (sPAP) during exercise in patients with SSc with normal resting haemodynamics may anticipate the development of PAH. Exercise echocardiography (ExEcho) has been proposed as a useful technique to identify exercise-induced increases in sPAP, but it is unclear how to clinically interpret these findings...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27328131/ba-filled-ni-sb-sn-based-skutterudites-with-anomalously-high-lattice-thermal-conductivity
#18
W Paschinger, G Rogl, A Grytsiv, H Michor, P R Heinrich, H Müller, S Puchegger, B Klobes, R P Hermann, M Reinecker, Ch Eisenmenger-Sitter, P Broz, E Bauer, G Giester, M Zehetbauer, P F Rogl
Novel filled skutterudites BayNi4Sb12-xSnx (ymax = 0.93) have been prepared by arc melting followed by annealing at 250, 350 and 450 °C up to 30 days in vacuum-sealed quartz vials. Extension of the homogeneity region, solidus temperatures and structural investigations were performed for the skutterudite phase in the ternary Ni-Sn-Sb and in the quaternary Ba-Ni-Sb-Sn systems. Phase equilibria in the Ni-Sn-Sb system at 450 °C were established by means of Electron Probe Microanalysis (EPMA) and X-ray Powder Diffraction (XPD)...
July 5, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27319091/-the-contribution-of-vascular-capacity-and-blood-volume-to-maintain-stable-blood-circulation-during-general-anesthesia
#19
REVIEW
Kenji Shigemi
To maintain proper cardiac preload is one of the most effective procedures for the systemic circulation remaining stable. In particular, the balance between vascular capacity and total blood volume must be maintained within appropriate range by the administration of fluids, blood and/or vasoactive drugs with mean circulatory filling pressure (Pmcf), central venous pressure (CVP) or stroke volume variation (SVV). End-diastolic left ventricular volume (Ved) is theoretically the best index of cardiac preload; however, without transesophageal echocardbalanceiogram we cannot directly monitor Ved during anesthesia...
May 2016: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/27289726/changes-on-mean-systemic-filling-pressure-and-microcirculation-after-a-fluid-challenge
#20
H D Aya, A Carsetti, S Pierantozzi, J Mellinghof, N Fletcher, A Rhodes, M Cecconi
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
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