Larissa Córdova Turones, Lucas S Machado, Boniek G Vaz, Gerlon de Almeida R Oliveira, Lorrane Kelle da Silva Moreira, Dionys de Souza Almeida, Aline Nazareth Martins, James Oluwagbamigbe Fajemiroye, José Luís R Martins, Paulo César Ghedini, Hericles Mesquita Campos, Fernanda Cristina A Dos Santos, Cinthia Rio Branco da Silva, Luciano M Lião, Eric de Souza Gil, Elson Alves Costa, Ricardo Menegatti
In the scope of a research program with the goal of developing treatments for inflammatory diseases, the pharmacological evaluation of LQFM291, designed by molecular hybridization from butylated hydroxytoluene and paracetamol, was described. The antioxidant profile of LQFM291 was evaluated by electrochemical measurement. Also, acute or repeated treatments with equimolar doses to paracetamol were used to evaluate the antinociceptive and/or anti-inflammatory activities of LQFM291 in animal models. The toxicologic potential of LQFM291 was also evaluated and compared to paracetamol through biochemical and histopathological analysis after the repeated treatment schedule...
September 4, 2023: Inflammopharmacology