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stress induced hyperalgesia

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https://www.readbyqxmd.com/read/29776484/corticotropin-releasing-factor-in-the-brain-and-blocking-spinal-descending-signals-induce-hyperalgesia-in-the-latent-sensitization-model-of-chronic-pain
#1
Wenling Chen, Yvette Taché, Juan Carlos Marvizón
Latent sensitization is a model of chronic pain in which an injury triggers a period of hyperalgesia followed by an apparent recovery, but in which pain sensitization persists but is suppressed by opioid and adrenergic receptors. One important characteristic of latent sensitization is that hyperalgesia can be triggered by acute stress. To determine whether the effect of stress is mimicked by the activation of corticotropin-releasing factor (CRF) signaling in the brain, rats with latent sensitization induced by injecting complete Freund's adjuvant (CFA, 50 μl) in one hind paw were given an intracerebroventricular (i...
June 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29715519/oxidative-stress-contributes-to-fracture-cast-induced-inflammation-and-pain-in-a-rat-model-of-complex-regional-pain-syndrome
#2
Tian-Zhi Guo, Tzuping Wei, Ting-Ting Huang, Wade S Kingery, John David Clark
Clinical evidence suggests vitamin C (Vit C) may protect against the development of complex regional pain syndrome (CRPS) after fracture and/or surgery. Tibia fracture followed by 4 weeks cast immobilization (fracture/cast) in rats results in nociceptive, vascular, and bone changes resembling clinical CRPS. In the present study, fracture/cast rats were treated with the oxidative stress inhibitors Vit C, N-acetyl cysteine (NAC) or 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL) to examine their effects on CRPS-related nociceptive and vascular changes...
April 28, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29700767/effects-of-post-weaning-chronic-stress-on-nociception-spinal-cord-%C3%AE-opioid-and-%C3%AE-2-adrenergic-receptors-expression-in-rats-and-their-offspring
#3
Asef Hormozi, Asadollah Zarifkar, Mohsen Tatar, Mahdi Barazesh, Bahar Rostami
Stressful situations can change biological process in human and animal, and some of these changes may transfer to the next generations. We used a communication box to induce chronic electrical foot-shock stress in rats. Tail flick latency and formalin test were done to determine the level of pain sensation. Real-time RT-PCR was used to measure the level of spinal cord μ-opioid (MOR) and α2-adrenergic receptors (α2-AR) mRNA. We demonstrate that chronic stress can change nociception and leads to hyperalgesia...
April 26, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29605417/linagliptin-attenuates-chronic-post-ischemia-pain-possible-anti-inflammatory-and-anti-oxidant-mechanisms
#4
Wafaa A Hewedy
Complex regional pain syndrome (CRPS) is a debilitating neurologic disorder with an interlinked and yet incompletely defined pathogenesis. Treatment options remain a therapeutic challenge. Linagliptin is one of the dipeptidyl peptidase-4 (DPP-4) inhibitors which are used for the treatment of diabetes mellitus. Apart from the improvement of glycemic control, accumulating evidence points to the beneficial effects of DPP-4 inhibitors in a wide array of conditions. Herein, the present study was outlined to investigate the antinociceptive effect of linagliptin in acute pain conditions, and in an animal model of CRPS...
March 29, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29571822/neonatal-maternal-separation-leads-to-a-dampening-of-inflammation-related-mechanical-and-thermal-hypersensitivity-in-juvenile-rats
#5
Julien Genty, Milène Tetsi Nomigni, Fernand Anton, Ulrike Hanesch
Early life stress (ELS) constitutes a risk factor for the later development of psychopathological disorders partly displaying pain comorbidity. Since ELS may hence be expected to have an impact on pain processing the present study investigates whether ELS could be a factor of vulnerability or resilience against an enhancement of noxious sensitivity in the framework of inflammatory pain in later life. Rats were exposed to the maternal separation (MS) paradigm, an established ELS model. At adulthood, corticosterone levels and anxiety-related behaviors were evaluated...
March 20, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29491683/gas-chromatography-mass-spectrometry-based-metabolomic-study-in-a-murine-model-of-irritable-bowel-syndrome
#6
Lei-Min Yu, Ke-Jia Zhao, Shuang-Shuang Wang, Xi Wang, Bin Lu
AIM: To study the role of microbial metabolites in the modulation of biochemical and physiological processes in irritable bowel syndrome (IBS). METHODS: In the current study, using a metabolomic approach, we analyzed the key metabolites differentially excreted in the feces of control mice and mice with IBS, with or without Clostridium butyricum (C. butyricum) treatment. C57BL/6 mice were divided into control, IBS, and IBS + C. butyricum groups. In the IBS and IBS + C...
February 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29432863/neonatal-handling-produces-sex-hormone-dependent-resilience-to-stress-induced-muscle-hyperalgesia-in-rats
#7
Pedro Alvarez, Paul G Green, Jon D Levine
Neonatal handling (NH) of male rat pups strongly attenuates stress response and stress-induced persistent muscle hyperalgesia in adults. Because female sex is a well established risk factor for stress-induced chronic muscle pain, we explored whether NH provides resilience to stress-induced hyperalgesia in adult female rats. Rat pups underwent NH, or standard (control) care. Muscle mechanical nociceptive threshold was assessed before and after water avoidance (WA) stress, when they were adults. In contrast to male rats, NH produced only a modest protection against WA stress-induced muscle hyperalgesia in female rats...
February 9, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29427084/rosmarinic-acid-mitigates-mitochondrial-dysfunction-and-spinal-glial-activation-in-oxaliplatin-induced-peripheral-neuropathy
#8
Aparna Areti, Prashanth Komirishetty, Anil Kumar Kalvala, Karthika Nellaiappan, Ashutosh Kumar
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting complication which develops as a consequence of treatment with chemotherapeutic agents like oxaliplatin and is a mainstay of therapy for colorectal cancer. Ever since CIPN was identified, understanding its exact pathomechanisms remains a clinical challenge. The role of mitochondrial dysfunction and glial cell activation has surfaced in the etiology of CIPN. Rosmarinic acid (RA), a known mitoprotectant exerts neuroprotection against the oxidative stress and neuroinflammation in various disease conditions...
February 9, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29423878/ginger-rhizome-enhances-the-anti-inflammatory-and-anti-nociceptive-effects-of-paracetamol-in-an-experimental-mouse-model-of-fibromyalgia
#9
Sergio Montserrat-de la Paz, Maria Dolores Garcia-Gimenez, Ana Maria Quilez, Rocio De la Puerta, Angeles Fernandez-Arche
BACKGROUND: The dried rhizome of ginger has been widely used for more than 2500 years in folk medicine for the treatment of various diseases that involve inflammation or are caused by oxidative stress. AIMS: This study was designed to compare the anti-nociceptive and anti-inflammatory effect of dried powdered ginger rhizome (GR) and paracetamol (APAP) on an experimental mouse model of fibromyalgia syndrome (FMS) induced by intermittent cold stress (ICS). METHODS: Forty-eight female C57BL/6 J mice were used for the experiments...
February 8, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29421433/the-neurotoxin-dsp-4-induces-hyperalgesia-in-rats-that-is-accompanied-by-spinal-oxidative-stress-and-cytokine-production
#10
Jillienne C Touchette, Joshua W Little, Gerald H Wilken, Daniela Salvemini, Heather Macarthur
Central neuropathic pain (CNP) a significant problem for many people, is not well-understood and difficult to manage. Dysfunction of the central noradrenergic system originating in the locus coeruleus (LC) may be a causative factor in the development of CNP. The LC is the major noradrenergic nucleus of the brain and plays a significant role in central modulation of nociceptive neurotransmission. Here, we examined CNS pathophysiological changes induced by intraperitoneal administration of the neurotoxin DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride)...
April 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29369967/lateralized-kappa-opioid-receptor-signaling-from-the-amygdala-central-nucleus-promotes-stress-induced-functional-pain
#11
Kelsey M Nation, Milena De Felice, Pablo I Hernandez, David W Dodick, Volker Neugebauer, Edita Navratilova, Frank Porreca
The response of diffuse noxious inhibitory controls (DNIC) is often decreased, or lost, in stress-related functional pain syndromes. Because the dynorphin/kappa opioid receptor (KOR) pathway is activated by stress, we determined its role in DNIC using a model of stress-induced functional pain. Male, Sprague-Dawley rats were primed for 7 days with systemic morphine resulting in opioid-induced hyperalgesia. Fourteen days after priming, when hyperalgesia was resolved, rats were exposed to environmental stress and DNIC was evaluated by measuring hind paw response threshold to noxious pressure (test stimulus) after capsaicin injection in the forepaw (conditioning stimulus)...
May 2018: Pain
https://www.readbyqxmd.com/read/29351168/coregulation-of-endoplasmic-reticulum-stress-and-oxidative-stress-in-neuropathic-pain-and-disinhibition-of-the-spinal-nociceptive-circuitry
#12
Yanhu Ge, Yingfu Jiao, Peiying Li, Zhenghua Xiang, Zhi Li, Long Wang, Wenqian Li, Hao Gao, Jiayun Shao, Daxiang Wen, Weifeng Yu
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) lumen leads to ER stress, which is related to cellular reactive oxygen species production. Neuropathic pain may result from spinal dorsal horn (SDH) ER stress. In this study, we examined the cause-effect relationship between ER stress and neuropathic pain using the spinal nerve ligation (SNL) rat model. We showed that ER stress was mutually promotive with oxidative stress during the process. We also tested the hypothesis that spinal sensitization arose from reduced activities of GABA-ergic interneurons and that spinal sensitization was mediated by SDH ER stress...
January 9, 2018: Pain
https://www.readbyqxmd.com/read/29324503/%C3%AE-asarone-alleviated-chronic-constriction-injury-induced-neuropathic-pain-through-inhibition-of-spinal-endoplasmic-reticulum-stress-in-an-liver-x-receptor-dependent-manner
#13
Yulong Gui, Aiyuan Li, Jie Zhang, Guan Li, Xia Ruan, Qulian Guo, Wangyuan Zou
BACKGROUND: Neuropathic pain is an intractable and complex disease. Recent studies have shown a close relationship between endoplasmic reticulum (ER) stress and neuropathic pain. Here, we investigated the effect of α-asarone, an ER stress inhibitor, on chronic constriction injury (CCI)-induced neuropathic pain. METHODS: Two parts were included in this study. In part 1, rats were assigned to 7 groups: the sham group, the sham + α-asarone 20 mg/kg group, the CCI group, the CCI + vehicle group, the CCI + α-asarone 5 mg/kg group, the CCI + α-asarone 10 mg/kg group, and the CCI + α-asarone 20 mg/kg group...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29322226/nebivolol-a-%C3%AE-blocker-abrogates-streptozotocin-induced-behavioral-biochemical-and-neurophysiological-deficit-by-attenuating-oxidative-nitrosative-stress-a-possible-target-for-the-prevention-of-diabetic-neuropathy
#14
Naini Bhadri, Rema Razdan, Sumanta Kumar Goswami
Metabolic abnormalities including hyperglycemia, hyperlipidemia, and oxidative-nitrosative stress are involved in the progression of diabetic neuropathy. In the present study, we targeted oxidative-nitrosative stress using nebivolol, a β1 -receptor antagonist with vasodilator and antioxidant property, to evaluate its neuroprotective effect in streptozotocin-induced diabetic neuropathy in rats. Diabetic neuropathy develops within 4-6 weeks after administration of streptozotocin (55 mg/kg, i.p.). Therefore, after confirmation of diabetes, subtherapeutic doses of nebivolol (1 and 2 mg/kg, p...
February 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29276736/maternal-separation-stress-leads-to-resilience-against-neuropathic-pain-in-adulthood
#15
Julien Genty, Milène Tetsi Nomigni, Fernand Anton, Ulrike Hanesch
Early life stress (ELS) leads to a permanent reprogramming of biochemical stress response cascades that may also be relevant for the processing of chronic pain states such as neuropathy. Despite clinical evidence, little is known about ELS-related vulnerability for neuropathic pain and the possibly underlying etiology. In the framework of experimental studies aimed at investigating the respective relationships we used the established ELS model of maternal separation (MS). Rat dams and neonates were separated for 3 h/day from post-natal day 2-12...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29241836/opposite-effects-of-stress-on-pain-modulation-depend-on-the-magnitude-of-individual-stress-response
#16
Nirit Geva, Ruth Defrin
The effect of acute stress on pain threshold and intolerance threshold are reported as producing either hypoalgesia or hyperalgesia. Yet, the contribution of individual stress reactivity in this respect has not been established. The aim was to test 2 pain modulation paradigms under acute stress manipulation, to our knowledge, for the first time, to study whether stress differentially affects pain modulation, and whether the effect is related to individual stress response. Participants were 31 healthy subjects...
December 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29235496/involvement-of-trpm2-and-trpv1-channels-on-hyperalgesia-apoptosis-and-oxidative-stress-in-rat-fibromyalgia-model-protective-role-of-selenium
#17
Esra Yüksel, Mustafa Nazıroğlu, Mehmet Şahin, Bilal Çiğ
Fibromyalgia (FM) results in pain characterized by low selenium (Se) levels, excessive Ca2+ influx, reactive oxygen species (ROS) production, and acidic pH. TRPM2 and TRPV1 are activated by ROS and acid; nevertheless, their roles have not been elucidated in FM. Therefore, we investigated the contribution of TRPM2 and TRPV1 to pain, oxidative stress, and apoptosis in a rat model of FM and the therapeutic potential of Se. Thirty-six rats were divided into four groups: control, Se, FM, and FM + Se. The Se treatment reduced the FM-induced increase in TRPM2 and TRPV1 currents, pain intensity, intracellular free Ca2+ , ROS, and mitochondrial membrane depolarization in the sciatic (SciN) and dorsal root ganglion (DRGN) neurons...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29197723/the-flavonoid-quercetin-inhibits-titanium-dioxide-tio-2-induced-chronic-arthritis-in-mice
#18
Sergio M Borghi, Sandra S Mizokami, Felipe A Pinho-Ribeiro, Victor Fattori, Jefferson Crespigio, Juliana T Clemente-Napimoga, Marcelo H Napimoga, Dimitrius L Pitol, João P M Issa, Sandra Y Fukada, Rubia Casagrande, Waldiceu A Verri
Titanium dioxide (TiO2 ) is a common component of orthopedic prosthesis. However, prosthesis wear releases TiO2 , which induces inflammation and osteolysis in peri-prosthetic tissues. Quercetin is a flavonoid widely present in human diet, which presents biological activities such as antinociceptive, anti-inflammatory and antioxidant effects. Therefore, the effect of intraperitoneal treatment with quercetin in TiO2 -induced arthritis model was evaluated. In the first set of experiments, mice received injection of TiO2 (0...
March 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29175003/transcranial-direct-current-stimulation-tdcs-prevents-chronic-stress-induced-hyperalgesia-in-rats
#19
F Fregni, I C Macedo, L N Spezia-Adachi, V L Scarabelot, G Laste, A Souza, Paulo Roberto Stefani Sanches, W Caumo, I L S Torres
BACKGROUND: Chronic stress (CS) is associated with a decrease in pain threshold caused by the changes in neural pain circuits. It can be associated to glucocorticoid imbalance with alterations in neural circuitry. Inhibition of stress-induced pain-related neural changes by using techniques that safely induce neuroplasticity such as transcranial direct current stimulation (tDCS) may prevent hyperalgesia triggered by CS. OBJECTIVE: This study aimed to verify the effect of tDCS performed prior to CS exposure on nociceptive response...
March 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29159784/g2a-as-a-threshold-regulator-of-inflammatory-hyperalgesia-modulates-chronic-hyperalgesia
#20
Yeu-Shiuan Su, Yu-Fen Huang, Jen Wong, Chia-Wei Lee, Wei-Shan Hsieh, Wei-Hsin Sun
Tissue injury, pathogen infection, and diseases are often accompanied by inflammation to release mediators that sensitize nociceptors and further recruit immune cells, which can lead to chronic hyperalgesia and inflammation. Tissue acidosis, occurring at the inflammatory site, is a major factor contributing to pain and hyperalgesia. The receptor G2 accumulation (G2A), expressed in neurons and immune cells, responds to protons or oxidized free fatty acids such as 9-hydroxyoctadecadienoic acid produced by injured cells or oxidative stresses...
January 2018: Journal of Molecular Neuroscience: MN
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