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#1
Barret Rush, Pawel Martinka, Robert C McDermid, John H Boyd, Leo Anthony Celi
No abstract text is available yet for this article.
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28643082/the-influence-of-solar-power-plants-on-microclimatic-conditions-and-the-biotic-community-in-chilean-desert-environments
#2
Anna Suuronen, Christian Muñoz-Escobar, Anssi Lensu, Markku Kuitunen, Natalia Guajardo Celis, Pablo Espinoza Astudillo, Marcos Ferrú, Andrés Taucare-Ríos, Marcelo Miranda, Jussi V K Kukkonen
The renewable energy sector is growing at a rapid pace in northern Chile and the solar energy potential is one of the best worldwide. Therefore, many types of solar power plant facilities are being built to take advantage of this renewable energy resource. Solar energy is considered a clean source of energy, but there are potential environmental effects of solar technology, such as landscape fragmentation, extinction of local biota, microclimate changes, among others. To be able to minimize environmental impacts of solar power plants, it is important to know what kind of environmental conditions solar power plants create...
June 22, 2017: Environmental Management
https://www.readbyqxmd.com/read/28642655/the-influence-of-passive-tobacco-exposure-and-physical-exercise-on-bone-tissue-of-young-rats
#3
Regina Celi Trindade Camargo, Regiane Rocha Costalonga, Mário Jefferson Quirino Louzada, Rômulo Araújo Fernandes, José Carlos Silva Camargo, Jacqueline Bexiga Urban
OBJECTIVE: The objective of this study is to investigate the effect of passive smoking during pregnancy and associated with swimming on bone area growth, bone mineral density (BMD), and bone mineral content (BMC). METHODS: The offspring was grouped by control matrices (G1) and passive smokers (G2). The offspring was regrouped in eight subgroups, with exposure to smoking (2x/day) and physical exercise (1 session/day), respecting the group of matrices in: sedentary control (G1CS and G2CS), swimming control (G1CN and G2CN), sedentary passive smoker (G1FS and G2FS), and passive smoker swimmer (G1FN and G2FN)...
March 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28642040/global-geriatric-oncology-achievements-and-challenges
#4
REVIEW
Enrique Soto-Perez-de-Celis, Nienke A de Glas, Tina Hsu, Ravindran Kanesvaran, Christopher Steer, Ana Patricia Navarrete-Reyes, Nicolo Matteo Luca Battisti, Yanin Chavarri-Guerra, Anita O'Donovan, Jose Alberto Avila-Funes, Arti Hurria
The aging of the population is a global challenge. The number of older adults is rapidly growing, leading to an increase in the prevalence of noncommunicable diseases associated with aging, such as cancer. Worldwide, older adults account for approximately half of all cancer cases, and this proportion is projected to increase globally. Furthermore, the majority of older adults live in less developed regions, where health systems are generally ill-equipped to provide care for complex chronic conditions. Worldwide, there is paucity of geriatric training, and most of the oncology workforce lacks the skills and knowledge to provide comprehensive care for older patients...
June 19, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28633082/role-of-indigenous-microbiota-from-heavily-contaminated-sediments-in-the-bioprecipitation-of-arsenic
#5
Erika E Rios-Valenciana, Roberto Briones-Gallardo, Luis F Cházaro-Ruiz, Nadia Martínez-Villegas, Lourdes B Celis
High arsenic concentrations have been detected in alluvial aquifers of arid and semi-arid zones in Mexico. This work describes the potential of microbial arsenate reduction of the indigenous community present in sediments from an arsenic contaminated aquifer. Microcosms assays were conducted to evaluate arsenate and sulfate-reducing activities of the native microbiota. Two different sediments were used as inoculum in the assays amended with lactate (10mM) as electron donor and with sulfate and arsenate (10mM each) as electron acceptors...
June 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28620021/correction-for-wolff-et-al-cell-type-dependent-regulation-of-mtorc1-by-redd1-and-the-tumor-suppressors-tsc1-tsc2-and-lkb1-in-response-to-hypoxia
#6
Nicholas C Wolff, Silvia Vega-Rubin-de-Celis, Xian-Jin Xie, Diego H Castrillon, Wareef Kabbani, James Brugarolas
No abstract text is available yet for this article.
July 1, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28615225/enhanced-therapeutic-efficacy-and-memory-of-tumor-specific-cd8-t-cells-by-ex-vivo-pi3k-%C3%AE-inhibition
#7
Rasha Abu-Eid, Shamim Ahmad, Yuan Lin, Mason Webb, Zuzana Berrong, Rajeev K Shrimali, Takumi Kumai, Sudha Ananth, Paulo C Rodriguez, Esteban Celis, John E Janik, Mikayel Mkrtichyan, Samir N Khleif
Inhibition of specific Akt isoforms in CD8+ T cells promotes favored differentiation into memory versus effector cells, the former of which are superior in mediating anti-tumor immunity. In this study, we investigated the role of upstream PI3K isoforms in CD8+ T cell differentiation and assessed the potential use of PI3K isoform-specific inhibitors to favorably condition CD8+ T cells for adoptive cell therapy. The phenotype and proliferative ability of tumor antigen specific CD8+ T cells was assessed in the presence of PI3K-α, -β, or -δ inhibitors...
June 14, 2017: Cancer Research
https://www.readbyqxmd.com/read/28608393/the-impact-of-the-use-of-intraoperative-radiotherapy-on-costs-travel-time-and-distance-for-women-with-breast-cancer-in-the-mexico-city-metropolitan-area
#8
Juan Enrique Bargallo-Rocha, Enrique Soto-Perez-de-Celis, Francisco Javier Picó-Guzmán, Carlos Eduardo Quintero-Rodríguez, David Almog, Gabriel Santiago-Concha, Christian Haydee Flores-Balcazar, Jaime Corona, Rafael Vazquez-Romo, Cynthia Villarreal-Garza, Alejandro Mohar
BACKGROUND AND OBJECTIVES: The low availability and poor access to external beam radiotherapy (EBRT) in developing countries makes it hard for women with breast cancer to receive breast conservation. We studied the effect of providing intraoperative radiotherapy (IORT) on the travel time, distance, and costs of in the Mexico City Metropolitan Area (MCMA). METHODS: Sixty-nine patients treated between January 2013 and September 2014 were analyzed. Travel distance and transit time was calculated using Google Maps...
June 12, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28602096/access-to-palliative-care-for-patients-undergoing-mechanical-ventilation-with-idiopathic-pulmonary-fibrosis-in-the-united-states
#9
Barret Rush, Landon Berger, Leo Anthony Celi
OBJECTIVE: The utilization of palliative care (PC) in patients with end-stage idiopathic pulmonary fibrosis (IPF) is not well understood. METHODS: The Nationwide Inpatient Sample (NIS) was utilized to examine the use of PC in mechanically ventilated (MV) patients with IPF. The NIS captures 20% of all US inpatient hospitalizations and is weighted to estimate 95% of all inpatient care. RESULTS: A total of 55 208 382 hospital admissions from the 2006 to 2012 NIS samples were examined...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28590037/epigenetic-effects-of-an-adenosine-derivative-in-a-wistar-rat-model-of-liver-cirrhosis
#10
Jesús Rafael Rodríguez-Aguilera, Carlos Guerrero-Hernández, Rosario Pérez-Molina, Carla Elizabeth Cadena-Del-Castillo, Rebeca Pérez-Cabeza de Vaca, Nuria Guerrero-Celis, Mariana Domínguez-López, Adrián Rafael Murillo-de-Ozores, Rodrigo Arzate-Mejía, Félix Recillas-Targa, Victoria Chagoya de Sánchez
The pathological characteristic of cirrhosis is scarring which results in a structurally distorted and dysfunctional liver. Previously, we demonstrated that Col1a1 and Pparg genes are deregulated in CCl4 -induced cirrhosis but their normal expression levels are recovered upon treatment with IFC-305, an adenosine derivative. We observed that adenosine was able to modulate S-adenosylmethionine-dependent trans-methylation reactions, and recently, we found that IFC-305 modulates HDAC3 expression. Here, we investigated whether epigenetic mechanisms, involving DNA methylation processes and histone acetylation, could explain the re-establishment of gene expression mediated by IFC-305 in cirrhosis...
June 7, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28579478/absolute-venomics-absolute-quantification-of-intact-venom-proteins-through-elemental-mass-spectrometry
#11
Francisco Calderón-Celis, Laura Cid-Barrio, Jorge Ruiz Encinar, Alfredo Sanz-Medel, Juan J Calvete
We report the application of a hybrid element and molecular MS configuration for the parallel absolute quantification of μHPLC-separated intact sulfur-containing venom proteins, via ICP triple quadrupole MS and (32)S/(34)S isotope dilution analysis, and identification by ESI-QToF-MS of the toxins of the medically important African black-necked spitting cobra, Naja nigricollis (Tanzania); New Guinea small-eyed snake, Micropechis ikaheka; and Papuan black snake, Pseudechis papuanus. The main advantage of this approach is that only one generic sulfur-containing standard is required to quantify each and all intact Cys- and/or Met-containing toxins of the venom proteome...
July 5, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28577728/socioeconomic-and-gender-disparities-in-anal-cancer-diagnosis-and-treatment
#12
Karel-Bart Celie, Christopher Jackson, Surbhi Agrawal, Chetan Dodhia, Carlos Guzman, Theodor Kaufman, Nicholas Hellenthal, Daphne Monie, Jose Monzon, Luis Oceguera
BACKGROUND AND OBJECTIVES: We investigated whether receipt of radiation in patients with anal carcinoma is related to income level and other demographic factors. METHODS: The SEER database (1988-2011) was queried and linked to the Area Health Resources File (AHRF). We used logistic regression and Kaplan-Meier analyses to correlate receipt of radiation and overall and cancer-specific survival with tumor stage, age, gender, and income. RESULTS: Of 28,028 patients with anal cancer, 14,783 (53%) received radiation...
June 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28574987/reconstruction-of-stented-coronary-arteries-from-optical-coherence-tomography-images-feasibility-validation-and-repeatability-of-a-segmentation-method
#13
Claudio Chiastra, Eros Montin, Marco Bologna, Susanna Migliori, Cristina Aurigemma, Francesco Burzotta, Simona Celi, Gabriele Dubini, Francesco Migliavacca, Luca Mainardi
Optical coherence tomography (OCT) is an established catheter-based imaging modality for the assessment of coronary artery disease and the guidance of stent placement during percutaneous coronary intervention. Manual analysis of large OCT datasets for vessel contours or stent struts detection is time-consuming and unsuitable for real-time applications. In this study, a fully automatic method was developed for detection of both vessel contours and stent struts. The method was applied to in vitro OCT scans of eight stented silicone bifurcation phantoms for validation purposes...
2017: PloS One
https://www.readbyqxmd.com/read/28560211/advanced-therapy-medicinal-products-for-rare-diseases-state-of-play-of-incentives-supporting-development-in-europe
#14
Andreas M Farkas, Segundo Mariz, Violeta Stoyanova-Beninska, Patrick Celis, Spiros Vamvakas, Kristina Larsson, Bruno Sepodes
In 2008, the European Union introduced the Advanced Medicines Regulation aiming to improve regulation of advanced therapy medicinal products (ATMPs). We applied the ATMPs classification definitions in this Regulation to understand the link of this emerging group of medicinal products and the use of the Orphan Regulation. A total of 185 products that can be classified as ATMPs based on this Regulation have been submitted for orphan designation. Prior to its introduction in 2008, 4.5% of the products submitted for orphan designation met these criteria...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28544702/within-person-reproducibility-and-sensitivity-to-dietary-change-of-c15-0-and-c17-0-levels-in-dried-blood-spots-data-from-the-european-food4me-study
#15
Viviana Albani, Carlos Celis-Morales, Clare B O'Donovan, Marianne C Walsh, Clara Woolhead, Hannah Forster, Rosalind Fallaize, Anna L Macready, Cyril F M Marsaux, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Christina Mavrogianni, Christina P Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo, Iwona Traczyk, Thomas E Gundersen, Christian A Drevon, Hannelore Daniel, Yannis Manios, J Alfredo Martinez, Wim H M Saris, Julie A Lovegrove, Michael J Gibney, Eileen R Gibney, John C Mathers, Ashley J Adamson, Lorraine Brennan
SCOPE: Previous work highlighted the potential of odd-chain length saturated fatty acids as potential markers of dairy intake. The aim of this study was to assess the reproducibility of these biomarkers and their sensitivity to changes in dairy intake. METHODS AND RESULTS: Fatty acid profiles and dietary intakes from food frequency questionnaires (FFQs) were measured three times over six months in the Food4Me Study. Reproducibility was explored through intra-class correlation coefficients (ICCs) and within-subject coefficients of variation (WCV)...
May 24, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28543373/acss2-gene-variant-associated-with-cleft-lip-and-palate-in-two-independent-hispanic-populations
#16
Sonam Dodhia, Katrina Celis, Alana Aylward, Yi Cai, Maria E Fontana, Alberto Trespalacios, David C Hoffman, Henry Ostos Alfonso, Sidney B Eisig, Gloria H Su, Wendy K Chung, Joseph Haddad
OBJECTIVES/HYPOTHESIS: A candidate variant (p.Val496Ala) of the ACSS2 gene (T > C missense, rs59088485 variant at chr20: bp37 33509608) was previously found to consistently segregate with nonsyndromic cleft lip and/or palate (NSCLP) in three Honduran families. Objectives of this study were 1) to investigate the frequency of this ACSS2 variant in Honduran unrelated NSCLP patients and unrelated unaffected controls and 2) to investigate the frequency of this variant in Colombian unrelated affected NSCLP patients and unrelated unaffected controls...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28536656/visual-rehabilitation-via-microperimetry-in-patients-with-geographic-atrophy-a-pilot-study
#17
Juan Abel Ramírez Estudillo, Mario Isaías León Higuera, Sergio Rojas Juárez, Maria de Lourdes Ordaz Vera, Yessica Pablo Santana, Benito Celis Suazo
BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. As a consequence of AMD, patients develop structural damage that comprises the fovea and subsequently present loss of central vision, low visual acuity and unstable fixation. Contrary to what happens with anti-angiogenic treatment in neovascular AMD, there is currently no definitive treatment to reverse geographic atrophy progression. The aim of this study was to determine the effectiveness of the visual rehabilitation treatment via microperimetry in patients with geographic atrophy...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28510497/clinical-development-and-commercialization-of-advanced-therapy-medicinal-products-in-the-european-union-how-are-the-product-pipeline-and-regulatory-framework-evolving
#18
Tomáš Boráň, Margarida Menezes-Ferreira, Ilona Reischl, Patrick Celis, Nicolas Ferry, Bernd Gänsbacher, Hartmut Krafft, Michele Lipucci di Paola, Dariusz Sladowski, Paula Salmikangas
The research and development of advanced therapy medicinal products (ATMPs) has been active in Europe and worldwide during recent years. Yet, the number of licensed products remains low. The main expected legal change in the near future in the European Union (EU) concerns the regulation on clinical trials (536/2014), which will come into force in 2018. With this new framework, a more harmonized and swift process for approval of clinical trials is anticipated, which is expected to support the entry of new innovations into the EU market...
May 16, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28489830/-clinical-and-laboratory-characteristics-of-patients-with-pulmonary-hypertension-and-pulmonary-vascular-complications-hospitalized-at-the-instituto-nacional-de-salud-del-ni%C3%A3-o
#19
Alexis Jose Ormeño Julca, Carlos Melchor Alvarez Murillo, Pedro Miguel Amoretti Alvino, Angel Aladino Florian Florian, Rosa Aurora Castro Johanson, Maria Danisa Celi Perez, Olga Rocío Huamán Prado
The hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PPHN) are distinct pulmonary vascular complications of portal hypertension (PHT) and are associated with increased morbidity and mortality. OBJECTIVES: To describe the clinical and laboratory characteristics of patients with pulmonary hypertension and pulmonary vascular complications hospitalized at the Instituto Nacional de Salud del Niño. MATERIALS AND METHODS: We included patients with HTP hospitalized from January 2012 to June 2013 and that during its evolution progressed with SHP or HTPP...
January 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28487772/incidence-and-risk-factors-for-early-acute-kidney-injury-in-nonsurgical-patients-a-cohort-study
#20
Javier Enrique Cely, Elkin José Mendoza, Carlos Roberto Olivares, Oscar Julián Sepúlveda, Juan Sebastián Acosta, Rafael Andrés Barón, Juan José Diaztagle
Introduction. Detecting acute kidney injury (AKI) in the first days of hospitalization could prevent potentially fatal complications. However, epidemiological data are scarce, especially on nonsurgical patients. Objectives. To determine the incidence and risk factors associated with AKI within five days of hospitalization (EAKI). Methods. Prospective cohort of patients hospitalized in the Internal Medicine Department. Results. A total of 16% of 400 patients developed EAKI. The associated risk factors were prehospital treatment with nephrotoxic drugs (2...
2017: International Journal of Nephrology
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