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https://www.readbyqxmd.com/read/28340437/assessment-of-microalga-biofilms-for-simultaneous-remediation-and-biofuel-generation-in-mine-tailings-water
#1
H Palma, E Killoran, M Sheehan, F Berner, K Heimann
Microalgae crops can generate a biochemical profile of high energy density and may be used for remediation of contaminated waste waters. This manuscript presents a laboratory-scale investigation into the potential for growing endemic microalgae biofilms in phosphorus-enriched nickel refinery tailings water, with an emphasis on product potential and the remediation of heavy metals. The dominant species of the consortia was a Chlorella-like microalga. The growth was monitored over time, with a productivity (0...
March 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28338439/stereotactic-radiosurgery-in-the-treatment-of-parasellar-meningiomas-long-term-volumetric-evaluation
#2
Or Cohen-Inbar, Athreya Tata, Shayan Moosa, Cheng-Chia Lee, Jason P Sheehan
OBJECTIVE Parasellar meningiomas tend to invade the suprasellar, cavernous sinus, and petroclival regions, encroaching on adjacent neurovascular structures. As such, they prove difficult to safely and completely resect. Stereotactic radiosurgery (SRS) has played a central role in the treatment of parasellar meningiomas. Evaluation of tumor control rates at this location using simplified single-dimension measurements may prove misleading. The authors report the influence of SRS treatment parameters and the timing and volumetric changes of benign WHO Grade I parasellar meningiomas after SRS on long-term outcome...
March 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28337924/making-sense-of-the-public-stigma-of-suicide
#3
Patrick W Corrigan, Lindsay Sheehan, Maya A Al-Khouja
BACKGROUND: Research suggests that stigma is a barrier to care for individuals who have attempted suicide. While extensive work has examined the stigma of mental illness, less research has focused on the public stigma of suicide. Existing measures of suicide stigma have lacked a conceptual foundation or have failed to include the perspectives of suicide stakeholders. AIMS: This research draws on previous qualitative research with suicide stakeholders to create a measure of public suicide stigma...
March 24, 2017: Crisis
https://www.readbyqxmd.com/read/28333513/feedback-in-group-psychotherapy-for-eating-disorders-a-randomized-clinical-trial
#4
Annika Helgadóttir Davidsen, Stig Poulsen, Jane Lindschou, Per Winkel, Marjun Frígerð Tróndarson, Mette Waaddegaard, Marianne Lau
OBJECTIVE: To investigate the effect of client feedback in group psychotherapy on attendance and treatment outcome for patients with eating disorders. METHOD: We conducted a randomized clinical trial with central randomization stratified for diagnosis and treatment type according to a computer-generated allocation sequence concealed to the investigators. One-hundred and 59 adult participants, diagnosed with bulimia nervosa, binge eating disorder, or eating disorder not otherwise specified according to DSM-IV, were included...
March 23, 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28314227/reliability-and-validity-of-chinese-version-of-perceived-deficits-questionnaire-for-depression-in-patients-with-mdd
#5
Chuan Shi, Gang Wang, Feng Tian, Xiaolei Han, Sha Sha, Xiaomeng Xing, Xin Yu
Although cognitive symptoms are prevalent and negatively affect psychosocial functioning, they are not commonly assessed in clinical practice, particularly in China. Perceived Deficits Questionnaire for Depression (PDQ-D) provides a subjective measure of cognitive dysfunction. This study aimed to examine the psychometric properties of Chinese version of PDQ-D in patients with MDD. The study sample comprised of 129 patients with MDD and 128 community volunteers. All patients with MDD were assessed with PDQ-D, Sheehan Disability Scale (SDS), Work Productivity and Activity Impairment: Specific Health Problem (WPAI-SPH), Patient Health Questionnaire-9 item (PHQ-9), and Digit Symbol Substitution Test (DSST)...
March 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28294394/cardioembolic-strokes-resulting-from-a-self-inflicted-needle-puncture-involving-both-sides-of-the-heart
#6
Mark Zheng Yi Tan, Annemarie Brunswicker, Shamsaldeen Abdelraheem, Alison Sheehan
Foreign bodies in the heart are rare occurrences with a limited evidence base to guide recommendations on management. We report a case of multiple cardioembolic strokes as a result of a self-inflicted sewing needle puncture from the anterior chest through the right ventricle and interventricular septum with its tip in the left ventricle close to the subvalvular apparatus in a 39-year-old psychiatric patient. We discuss issues surrounding decision making and ongoing care and highlight the importance of further follow-up and reporting of cases to form a robust evidence base to guide future recommendations...
March 14, 2017: Echocardiography
https://www.readbyqxmd.com/read/28293465/the-effect-of-vortioxetine-on-overall-patient-functioning-in-patients-with-major-depressive-disorder
#7
Ioana Florea, Henrik Loft, Natalya Danchenko, Benoît Rive, Melanie Brignone, Elizabeth Merikle, Paula L Jacobsen, David V Sheehan
BACKGROUND: The objectives of this meta-analysis of data from randomized, placebo-controlled studies were to assess the effect of vortioxetine on overall functioning (primary) and functional remission (secondary) using the Sheehan Disability Scale (SDS) in adults with major depressive disorder (MDD). METHODS: Data from nine short-term (6/8 weeks) pivotal studies that included patient functioning assessments were included in this random-effects meta-analysis, which used aggregated study-level data for all therapeutic vortioxetine doses and a mixed-effect model for repeated measures using the full analysis set...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28291818/challenges-and-opportunities-in-understanding-dementia-and-delirium-in-the-acute-hospital
#8
Thomas A Jackson, John R F Gladman, Rowan H Harwood, Alasdair M J MacLullich, Elizabeth L Sampson, Bart Sheehan, Daniel H J Davis
In an Essay, Andrew Jackson and colleagues discuss challenges in the diagnosis and management of older people with dementia and delirium in acute hospitals.
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28290773/the-hiv-care-cascade-and-sub-analysis-of-those-linked-to-but-not-retained-in-care-the-experience-from-a-tertiary-hiv-referral-service-in-dublin-ireland
#9
P McGettrick, B Ghavami-Kia, W Tinago, A Macken, J O'Halloran, J S Lambert, G Sheehan, P W G Mallon
BACKGROUND: The HIV Care Cascade model can be used to measure how clinical services align with United Nations' (UN) HIV treatment targets. Previous models have highlighted sequential losses at each step of the Cascade with a significant proportion being not retained in care (NRIC). OBJECTIVE: We aimed to assess the feasibility of meeting the UN targets and assess factors associated with, and calculate the true proportion of those, NRIC. METHODS: All people living with HIV who were linked to our service, one of three specialist HIV care providers in Dublin Ireland, from its establishment in 1993 to 1 December 2014, were included in the cohort and were categorized as linked to care, retained in care (RIC), on antiretroviral therapy (on ART), virally suppressed (HIV RNA <40copies/ml), and NRIC...
March 14, 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/28282947/disparity-in-retention-in-care-and-viral-suppression-for-black-caribbean-born-immigrants-living-with-hiv-in-florida
#10
Elena Cyrus, Christyl Dawson, Kristopher P Fennie, Diana M Sheehan, Daniel E Mauck, Mariana Sanchez, Lorene M Maddox, Mary Jo Trepka
(1) The study aim was to assess disparities in non-retention in HIV care and non-viral suppression among non-Hispanic Black Caribbean immigrants living with HIV in Florida. (2) We analyzed cases involving individuals, aged ≥13, who met CDC HIV case definition during 2000-2014. Chi square test was used to evaluate differences in non-retention and non-viral suppression by country of origin/race/ethnicity. Multilevel logistic regressions with three referent groups [US-born Blacks, Hispanics, and non-Hispanic Whites (NHWs)] were used to estimate adjusted odds ratios (aOR)...
March 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28277311/the-fact-and-the-fiction-a-prospective-study-of-internet-forum-discussions-on-vaginal-breech-birth
#11
Karolina Petrovska, Athena Sheehan, Caroline S E Homer
BACKGROUND: Women with a breech baby late in pregnancy may use the internet to gather information to assist in decision-making for birth. The aim of this study was to examine how women use English language internet discussion forums to find out information about vaginal breech birth and to increase understanding of how vaginal breech birth is perceived among women. METHOD: A descriptive qualitative study of internet discussion forums was undertaken. Google alerts were created with the search terms "breech birth" and "breech"...
October 26, 2016: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28274957/an-acquired-her2-t798i-gatekeeper-mutation-induces-resistance-to-neratinib-in-a-patient-with-her2-mutant-driven-breast-cancer
#12
Ariella B Hanker, Monica Red Brewer, Jonathan H Sheehan, James P Koch, Gregory R Sliwoski, Rebecca Nagy, Richard Lanman, Michael F Berger, David M Hyman, David B Solit, Jie He, Vincent Miller, Richard E Cutler, Alshad S Lalani, Darren Cross, Christine M Lovly, Jens Meiler, Carlos L Arteaga
We report a HER2T798I gatekeeper mutation in a patient with HER2L869R-mutant breast cancer with acquired resistance to neratinib. Laboratory studies suggested that HER2L869R is a neratinib-sensitive, gain-of-function mutation that upon dimerization with mutant HER3E928G, also present in the breast cancer, amplifies HER2 signaling. The patient was treated with neratinib and exhibited a sustained partial response. Upon clinical progression, HER2T798I was detected in plasma tumor cell-free DNA. Structural modeling of this acquired mutation suggested that the increased bulk of isoleucine in HER2T798I reduces neratinib binding...
March 8, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28274139/immune-and-viral-therapies-for-malignant-primary-brain-tumors
#13
Andrew M Gardeck, Jordan Sheehan, Walter C Low
Glioblastoma multiforme (GBM) is a primary brain tumor with great lethality. Current standard of care with surgery, radiation therapy, and chemotherapy are ineffective in curing this disease. Recent advancements in biological therapies show promise in treating brain tumors. Areas covered: This article provides a review of: the peripheral activation of antigen presenting cells such as dendritic cells to stimulate T cells to recognize and destroy tumor cells within the brain; the ex vivo expansion and transfer of dendritic cells, T cells, and engineered T cells expressing chimeric antigen receptors to target cells bearing specific tumor antigens as well as monoclonal antibodies as immune check point inhibitors...
April 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28273181/evaluating-lung-cancer-screening-in-china-implications-for-eligibility-criteria-design-from-a-microsimulation-modeling-approach
#14
Deirdre F Sheehan, Steven D Criss, G Scott Gazelle, Pari V Pandharipande, Chung Yin Kong
More than half of males in China are current smokers and evidence from western countries tells us that an unprecedented number of smoking-attributable deaths will occur as the Chinese population ages. We used the China Lung Cancer Policy Model (LCPM) to simulate effects of computed tomography (CT)-based lung cancer screening in China, comparing the impact of a screening guideline published in 2015 by a Chinese expert group to a version developed for the United States by the U.S. Centers for Medicare & Medicaid Services (CMS)...
2017: PloS One
https://www.readbyqxmd.com/read/28272076/hypopituitarism-presenting-as-congestive-heart-failure
#15
S Giri, P Bansal, S Malik, R Bansal
Sheehan's syndrome (SS) develops as a result of ischemic pituitary necrosis due to severe postpartum hemorrhage and is characterized by various degrees of hypopituitarism. Although the occurrence of SS is now rare, it should still be considered in any woman with a history of peripartum hemorrhage who develops manifestations of pituitary hormone deficiency any time following the event. Appropriate hormone replacement therapy results in marked clinical improvement. We present an unusual case of SS in a young lady who continued to have normal menstruation after the index event, had two spontaneous pregnancies, and was diagnosed only 11 years later when she presented to us with acute heart failure...
March 3, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28264739/remission-and-recovery-associated-with-lurasidone-in-the-treatment-of-major-depressive-disorder-with-subthreshold-hypomanic-symptoms-mixed-features-post-hoc-analysis-of-a-randomized-placebo-controlled-study-with-longer-term-extension
#16
Joseph F Goldberg, Daisy Ng-Mak, Cynthia Siu, Chien-Chia Chuang, Krithika Rajagopalan, Antony Loebel
OBJECTIVE: This post-hoc analysis assessed rates of symptomatic and functional remission, as well as recovery (combination of symptomatic and functional remission), in patients treated with lurasidone for major depressive disorder (MDD) associated with subthreshold hypomanic symptoms (mixed features). METHOD: Patients with MDD plus two or three manic symptoms (defined as per the DSM-5 mixed-features specifier) were randomly assigned to flexible-dose lurasidone 20-60 mg/day (n=109) or placebo (n=100) for 6 weeks, followed by a 3-month open-label, flexible-dose extension study for U...
March 7, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28262158/psychosis-as-a-late-manifestation-of-sheehan-s-syndrome
#17
Mukku Shiva Shanker Reddy, Abhinav Nahar, Harish Thippeswamy, Chaturvedi Santosh Kumar
Sheehan's syndrome occurs as a result of ischemic pituitary necrosis due to severe postpartum haemorrhage. It is one of the most common causes of hypopituitarism in underdeveloped or developing countries. Characteristic manifestations include failure to lactate or to resume menses, genital and axillary hair loss, asthenia and weakness, fine wrinkles around the eyes and lips, signs of premature aging, dry skin, hypopigmentation and other evidence of hypopituitarism. Uncommonly it can present with psychosis. There are only few case reports of psychoses in patients with Sheehan's syndrome...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28245165/family-caregiver-recruitment-via-social-media-challenges-opportunities-and-lessons
#18
Dana Hansen, Denice K Sheehan, Pam Stephenson
BACKGROUND: Illness blogs are a way seriously ill people communicate publicly about their illness journey. As communication about serious illness increases on social media, it is important to evaluate how this affects the family caregiver. However, identifying and accessing family caregivers remains challenging, especially via social media. PURPOSE: The aim of this article is to report the opportunities, challenges and lessons learned from using social media to recruit family caregivers...
February 2, 2017: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/28221059/emotion-focused-therapy-for-social-anxiety-disorder-results-from-a-multiple-baseline-study
#19
Ben Shahar, Eran Bar-Kalifa, Eve Alon
OBJECTIVE: The purpose of the present study was to evaluate the efficacy of emotion-focused therapy (EFT) for adults suffering from social anxiety disorder (SAD). METHOD: Using a nonconcurrent multiple-baseline design, 12 patients (mean age = 26.75 years, SD = 5.15; 7 males) meeting criteria for SAD were treated with up to 28 sessions of EFT. EFT was based on an empathic relationship, 2-chair work for self-criticism, empty-chair work for unresolved feelings, and focusing...
March 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28213602/understanding-the-epidemiology-of-avoidable-significant-harm-in-primary-care-protocol-for-a-retrospective-cross-sectional-study
#20
Brian G Bell, Stephen Campbell, Andrew Carson-Stevens, Huw Prosser Evans, Alison Cooper, Christina Sheehan, Sarah Rodgers, Christine Johnson, Adrian Edwards, Sarah Armstrong, Rajnikant Mehta, Antony Chuter, Ailsa Donnelly, Darren M Ashcroft, Joanne Lymn, Pam Smith, Aziz Sheikh, Matthew Boyd, Anthony J Avery
INTRODUCTION: Most patient safety research has focused on specialist-care settings where there is an appreciation of the frequency and causes of medical errors, and the resulting burden of adverse events. There have, however, been few large-scale robust studies that have investigated the extent and severity of avoidable harm in primary care. To address this, we will conduct a 12-month retrospective cross-sectional study involving case note review of primary care patients. METHODS AND ANALYSIS: We will conduct electronic searches of general practice (GP) clinical computer systems to identify patients with avoidable significant harm...
February 17, 2017: BMJ Open
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