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https://www.readbyqxmd.com/read/28105704/mother-nature-versus-father-time
#1
Helena C Parkington, Penelope M Sheehan, Harold A Coleman, Shaun P Brennecke
In high-income countries, the average age at which women are giving birth to their first child has increased steadily in recent years. This article is protected by copyright. All rights reserved.
January 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28099098/evaluation-of-peripheral-arterial-disease-with-nonenhanced-quiescent-interval-single-shot-mr-angiography
#2
Philip A Hodnett, Ioannis Koktzoglou, Amir H Davarpanah, Timothy G Scanlon, Jeremy D Collins, John J Sheehan, Eugene E Dunkle, Navyash Gupta, James C Carr, Robert R Edelman
No abstract text is available yet for this article.
February 2017: Radiology
https://www.readbyqxmd.com/read/28074423/effectiveness-of-risk-evaluation-and-mitigation-strategies-rems-for-lenalidomide-and-thalidomide-patient-comprehension-and-knowledge-retention
#3
Nancy A Brandenburg, Robert Bwire, John Freeman, Florence Houn, Paul Sheehan, Jerome B Zeldis
INTRODUCTION: The effectiveness of patient education activities conducted within the lenalidomide and thalidomide risk evaluation and mitigation strategies (REMS) programs was evaluated by measuring understanding of serious risk and safe-use messages. METHODS: Results from mandatory knowledge, attitude, and behavior surveys and voluntary patient surveys completed between June 2012 and June 2013 were analyzed, and responses to questions relating to compliance with birth control measures and understanding of safe-use messages are presented by patient risk category...
January 10, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28072643/early-life-trauma-in-hospitalized-patients-with-mood-disorders-and-its-association-with-clinical-outcomes
#4
Ajay K Parsaik, Noha Abdelgawad, Jigar K Chotalia, Scott D Lane, Teresa A Pigott
BACKGROUND: The prevalence of childhood trauma and its impact on clinical outcomes in hospitalized patients with mood disorders is unknown. We studied the frequency of childhood trauma among inpatient adults with mood disorders and its association with clinical outcomes. METHODS: Patients admitted to our hospital with a primary diagnosis of mood disorders completed the short form of the Early Trauma Inventory-Self-Report (ETISR-SF), the Sheehan Disability Scale, and the Clinician-Rated Dimensions of Psychosis Symptom Severity scale...
January 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28070303/using-species-distribution-models-to-define-nesting-habitat-of-the-eastern-metapopulation-of-double-crested-cormorants
#5
Kate L Sheehan, Samuel T Esswein, Brian S Dorr, Greg K Yarrow, Ron J Johnson
When organisms with similar phenotypes have conflicting management and conservation initiatives, approaches are needed to differentiate among subpopulations or discrete groups. For example, the eastern metapopulation of the double-crested cormorant (Phalacrocorax auritus) has a migratory phenotype that is culled because they are viewed as a threat to commercial and natural resources, whereas resident birds are targeted for conservation. Understanding the distinct breeding habitats of resident versus migratory cormorants would aid in identification and management decisions...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28068615/effects-of-levomilnacipran-er-on-noradrenergic-symptoms-anxiety-symptoms-and-functional-impairment-in-adults-with-major-depressive-disorder-post-hoc-analysis-of-5-clinical-trials
#6
Pierre Blier, Carl Gommoll, Changzheng Chen, Kenneth Kramer
OBJECTIVE: To evaluate the effects of levomilnacipran extended-release (LVM-ER; 40-120mg/day) on noradrenergic (NA) and anxiety-related symptoms in adults with major depressive disorder (MDD) and explore the relationship between these symptoms and functional impairment. METHODS: Data were pooled from 5 randomized, double-blind, placebo-controlled trials (N=2598). Anxiety and NA Cluster scores were developed by adding selected item scores from the Montgomery-Åsberg Depression Rating Scale (MADRS) and 17-item Hamilton Depression Rating Scale (HAMD17)...
November 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28060206/tbi-and-treatment-response-in-a-randomized-trial-of-acceptance-and-commitment-therapy
#7
Jessica Bomyea, Ariel J Lang, Paula P Schnurr
OBJECTIVE: Traumatic brain injury (TBI) occurs in a substantial minority of military personnel, and commonly is associated with mental health disorders and postconcussive symptoms (PCS). The implications of TBI for mental health treatment are not well understood. The present study sought to describe psychotherapy response in veterans with and without TBI. DESIGN: This is a secondary analysis from a 2-group randomized controlled trial. SETTING, PARTICIPANTS, AND MEASURES: One hundred and sixty male and female veterans participated in a multisite randomized controlled trial of Acceptance and Commitment Therapy versus Present Centered Therapy; a subset of 129 veterans were included in these analyses...
January 5, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28059663/the-effect-of-timing-of-stereotactic-radiosurgery-treatment-of-melanoma-brain-metastases-treated-with-ipilimumab
#8
Or Cohen-Inbar, Han-Hsun Shih, Zhiyuan Xu, David Schlesinger, Jason P Sheehan
OBJECTIVE Melanoma represents the third most common cause of CNS metastases. Immunotherapy has evolved as a treatment option for patients with Stage IV melanoma. Stereotactic radiosurgery (SRS) also elicits an immune response within the brain and may interact with immunotherapy. The authors report on a cohort of patients treated for brain metastases with immunotherapy and evaluate the effect of SRS timing on the intracranial response. METHODS All consecutively treated melanoma patients receiving ipilimumab and SRS for treatment of brain metastases at the University of Virginia between 2009 and 2014 were included in this retrospective analysis; data from 46 patients harboring 232 brain metastases were reviewed...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28056523/the-tibial-tubercle-trochlear-groove-distance-is-greater-in-patients-with-patellofemoral-pain
#9
Victor R Carlson, Barry P Boden, Aricia Shen, Jennifer N Jackson, Lawrence Yao, Frances T Sheehan
BACKGROUND: The distance between the tibial tubercle (TT) and trochlear groove (TT-TG distance) is known to be greater in patients with patellar instability. However, the potential role and prevalence of pathological TT-TG distances in a large cohort of skeletally mature patients with isolated patellofemoral pain (PFP) are not clear. PURPOSE: To determine if the mean TT-TG distance is greater in patients with PFP, who lack a history of patellar dislocations, knee trauma, or osteoarthritis, relative to healthy controls...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28045747/next-generation-sequencing-reveals-pathway-activations-and-new-routes-to-targeted-therapies-in-cutaneous-metastatic-melanoma
#10
J Andrew Carlson, Jose Candido Caldeira Xavier, Ashley Tarasen, Christine E Sheehan, Geoff Otto, Vincent A Miller, Philip J Stephens, Julia A Elvin, Jo-Anne Vergilio, James Suh, Laurie M Gay, Jeffrey S Ross
BACKGROUND: Comprehensive genomic profiling of clinical samples by next-generation sequencing (NGS) can identify one or more therapy targets for the treatment of metastatic melanoma (MM) with a single diagnostic test. METHODS: NGS was performed on hybridization-captured, adaptor ligation-based libraries using DNA extracted from 4 formalin-fixed paraffin-embedded sections cut at 10 microns from 30 MM cases. The exons of 182 cancer-related genes were fully sequenced using the Illumina HiSeq 2000 at an average sequencing depth of 1098X and evaluated for genomic alterations (GAs) including point mutations, insertions, deletions, copy number alterations, and select gene fusions/rearrangements...
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28044461/equivalence-of-cell-survival-data-for-radiation-dose-and-thermal-dose-in-ablative-treatments-analysis-applied-to-essential-tremor-thalamotomy-by-focused-ultrasound-and-gamma-knife
#11
D Schlesinger, M Lee, G Ter Haar, B Sela, M Eames, J Snell, N Kassell, J Sheehan, J Larner, J-F Aubry
Thermal dose and absorbed radiation dose have historically been difficult to compare because different biological mechanisms are at work. Thermal dose denatures proteins and the radiation dose causes DNA damage in order to achieve ablation. The purpose of this paper is to use the proportion of cell survival as a potential common unit by which to measure the biological effect of each procedure. Survival curves for both thermal and radiation doses have been extracted from previously published data for three different cell types...
January 3, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28044458/application-of-bayesian-networks-for-hazard-ranking-of-nanomaterials-to-support-human-health-risk-assessment
#12
Hans J P Marvin, Yamine Bouzembrak, Esmée M Janssen, Meike van der Zande, Finbarr Murphy, Barry Sheehan, Martin Mullins, Hans Bouwmeester
In this study a Bayesian Network (BN) was developed for the prediction of the hazard potential and biological effects with the focus on metal- and metal-oxide nanomaterials to support human health risk assessment. The developed BN captures the (inter) relationships between the exposure route, the nanomaterials physicochemical properties, and the ultimate biological effects in a holistic manner and was based on international expert consultation and the scientific literature (e.g. in vitro/in vivo data). The BN was validated with independent data extracted from published studies and the accuracy of the prediction of the nanomaterials hazard potential was 72% and for the biological effect 71%, respectively...
January 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28040818/contact-allergy-to-poliglecaprone-25-sutures
#13
Andrew Scheman, Ella-Marie Rakowski, Jessica Sheehan, Tracy Campbell, Amy Derick
No abstract text is available yet for this article.
November 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28035647/offending-behavior-drug-use-and-mental-health-among-foreign-born-versus-u-s-born-latino-criminal-justice-clients
#14
Gladys E Ibañez, Michelle Agudo, Steve S Martin, Daniel J O'Connell, Rehab Auf, Diana M Sheehan
Little is known about the offending behavior and recidivism factors of Latinos by nativity (U.S. born, foreign-born). The present study focused on Latinos in community corrections (n = 201) in Miami, Florida, and examined differences in criminal activity, drug use, and mental health by nativity. Data were collected utilizing convenience sampling between June 2014 and December 2015. The research question was: what are the offending, drug use, and mental health histories of Latinos involved in community corrections? Participants were mostly male (n = 120; 59...
December 30, 2016: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28030746/association-of-fluid-intelligence-and-psychiatric-disorders-in-a-population-representative-sample-of-us-adolescents
#15
Katherine M Keyes, Jonathan Platt, Alan S Kaufman, Katie A McLaughlin
Importance: Despite long-standing interest in the association of psychiatric disorders with intelligence, few population-based studies of psychiatric disorders have assessed intelligence. Objective: To investigate the association of fluid intelligence with past-year and lifetime psychiatric disorders, disorder age at onset, and disorder severity in a nationally representative sample of US adolescents. Design, Setting, and Participants: National sample of adolescents ascertained from schools and households from the National Comorbidity Survey Replication-Adolescent Supplement, collected 2001 through 2004...
December 28, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/28029800/patellofemoral-kinematics-and-tibial-tuberosity-trochlear-groove-distances-in-female-adolescents-with-patellofemoral-pain
#16
Victor R Carlson, Barry P Boden, Frances T Sheehan
BACKGROUND: Patellofemoral pain (PFP) is a prevalent disorder among female adolescents. Overuse is frequently cited as the cause of pain for this population. What is currently unclear, however, is if the patella demonstrates abnormal tracking patterns relative to the femoral trochlear groove in female adolescents with PFP. PURPOSE: The aim of this case-control study was to determine if abnormal patellar tracking patterns are present in female adolescents with PFP...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28010177/insight-into-the-stigma-of-suicide-loss-survivors-factor-analyses-of-family-stereotypes-prejudices-and-discriminations
#17
Patrick W Corrigan, Lindsay Sheehan, Maya Al-Khouja, Stanley Lewy, Deborah R Major, Jessica Mead, Megghun Redmon, Charles T Rubey, Stephanie Weber
Families of individuals who die by suicide report public stigma that threatens their well-being. This study used a community-based participatory (CBPR) approach to describe a factor structure for the family stigma of suicide. Candidate items (n = 82) from a previous qualitative study were presented in an online survey format. Members of the public (n = 232) indicated how much they thought items represented public views and behaviors towards family members who lost a loved one to suicide. Factor analyses revealed two factors for stereotypes (dysfunctional, blameworthy), one factor for prejudice (fear and distrust) and three factors for discrimination (exclusion, secrecy and avoidance)...
December 23, 2016: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/28009246/locating-risk-in-the-adolescent-brain-ethical-challenges-in-the-use-of-biomarkers-for-adolescent-health-and-social-policy
#18
Suparna Choudhury, Sheehan Moore
Technological developments in neuroscience over the last 20 years have generated excitement about the potential of neuroscientific insights for the understanding of and intervention in children's and adolescents' behavior. This article introduces some ways in which new results from developmental cognitive neuroscience have been appropriated in the context of adolescent mental health. We also consider social and interpersonal factors that drive the use of neurobiological markers of mental disorders in pediatric psychiatry...
December 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28008002/pregnancy-outcomes-after-clinical-recovery-from-aki
#19
Jessica Sheehan Tangren, Camille E Powe, Elizabeth Ankers, Jeffrey Ecker, Kate Bramham, Michelle A Hladunewich, S Ananth Karumanchi, Ravi Thadhani
The effect of clinically recovered AKI (r-AKI) on future pregnancy outcomes is unknown. We retrospectively studied all women who delivered infants between 1998 and 2007 at Massachusetts General Hospital to assess whether a previous episode of r-AKI associated with subsequent adverse maternal and fetal outcomes, including preeclampsia. AKI was defined as rise in serum creatinine concentration to 1.5-fold above baseline. We compared pregnancy outcomes in women with r-AKI without history of CKD (eGFR>90 ml/min per 1...
December 22, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28004764/sheehan-syndrome
#20
Züleyha Karaca, Bashir A Laway, Hatice S Dokmetas, Hulusi Atmaca, Fahrettin Kelestimur
Sheehan syndrome or postpartum hypopituitarism is a condition characterized by hypopituitarism due to necrosis of the pituitary gland. The initial insult is caused by massive postpartum haemorrhage (PPH), leading to impaired blood supply to the pituitary gland, which has become enlarged during pregnancy. Small sella turcica size, vasospasms (caused by PPH) and/or thrombosis (associated with pregnancy or coagulation disorders) are predisposing factors; autoimmunity might be involved in the progressive worsening of pituitary functions...
December 22, 2016: Nature Reviews. Disease Primers
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