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https://www.readbyqxmd.com/read/29769247/dementia-and-physical-activity-dapa-trial-of-moderate-to-high-intensity-exercise-training-for-people-with-dementia-randomised-controlled-trial
#1
Sarah E Lamb, Bart Sheehan, Nicky Atherton, Vivien Nichols, Helen Collins, Dipesh Mistry, Sukhdeep Dosanjh, Anne Marie Slowther, Iftekhar Khan, Stavros Petrou, Ranjit Lall
OBJECTIVE: To estimate the effect of a moderate to high intensity aerobic and strength exercise training programme on cognitive impairment and other outcomes in people with mild to moderate dementia. DESIGN: Multicentre, pragmatic, investigator masked, randomised controlled trial. SETTING: National Health Service primary care, community and memory services, dementia research registers, and voluntary sector providers in 15 English regions. PARTICIPANTS: 494 people with dementia: 329 were assigned to an aerobic and strength exercise programme and 165 were assigned to usual care...
May 16, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29762746/microsurgery-versus-stereotactic-radiosurgery-for-brain-arteriovenous-malformations-a-matched-cohort-study
#2
Ching-Jen Chen, Dale Ding, Tony R Wang, Thomas J Buell, Adeel Ilyas, Natasha Ironside, Cheng-Chia Lee, M Yashar Kalani, Min S Park, Kenneth C Liu, Jason P Sheehan
BACKGROUND: Microsurgery (MS) and stereotactic radiosurgery (SRS) remain the preferred interventions for the curative treatment of brain arteriovenous malformations (AVM), but their relative efficacy remains incompletely defined. OBJECTIVE: To compare the outcomes of MS to SRS for AVMs through a retrospective, matched cohort study. METHODS: We evaluated institutional databases of AVM patients who underwent MS and SRS. MS-treated patients were matched, in a 1:1 ratio based on patient and AVM characteristics, to SRS-treated patients...
May 12, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29762074/use-of-artificial-hydration-at-the-end-of-life-a-survey-of-australian-and-new-zealand-palliative-medicine-doctors
#3
Jacqueline Oehme, Caitlin Sheehan
BACKGROUND: Dying is ubiquitous, yet the optimal management of hydration in the terminal phase is undetermined. Palliative care (PC) doctors' practices may act as a de facto measure of the benefits and burdens of artificial hydration (AH) use. OBJECTIVE: To identify PC doctors' AH prescribing practices for imminently dying patients and possible influencing factors. METHODS: An online survey of doctors belonging to the Australian and New Zealand Society of Palliative Medicine...
May 15, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29757421/stereotactic-radiosurgery-for-acromegaly-an-international-multicenter-retrospective-cohort-study
#4
Dale Ding, Gautam U Mehta, Mohana Rao Patibandla, Cheng-Chia Lee, Roman Liscak, Hideyuki Kano, Fu-Yuan Pai, Mikulas Kosak, Nathaniel D Sisterson, Roberto Martinez-Alvarez, Nuria Martinez-Moreno, David Mathieu, Inga S Grills, Kevin Blas, Kuei Lee, Christopher P Cifarelli, Gennadiy A Katsevman, John Y K Lee, Brendan McShane, Douglas Kondziolka, L Dade Lunsford, Mary Lee Vance, Jason P Sheehan
BACKGROUND: Stereotactic radiosurgery (SRS) is a treatment option for persistent or recurrent acromegaly secondary to a growth hormone secreting pituitary adenoma, but its efficacy is inadequately defined. OBJECTIVE: To assess, in a multicenter, retrospective cohort study, the outcomes of SRS for acromegaly and determine predictors. METHODS: We pooled and analyzed data from 10 participating institutions of the International Gamma Knife Research Foundation for patients with acromegaly who underwent SRS with endocrine follow-up of ≥6 mo...
May 10, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29757097/stigma-and-suicidality-among-suicide-attempt-survivors-a-qualitative-study
#5
Nathalie Oexle, Katharina Herrmann, Tobias Staiger, Lindsay Sheehan, Nicolas Rüsch, Silvia Krumm
Among people with mental illness, stigma experiences can increase suicidality, and suicidality itself is associated with negative stereotypes. Suicide attempt survivors experience both mental illness stigma and suicide stigma, which could contribute to their increased risk for completed suicide. We interviewed 13 suicide attempt survivors regarding experiences and consequences of stigma and identified five stigma-related themes. Stigma led to substantial emotional strain, including loneliness and hopelessness, which are important precursors of suicidality...
May 14, 2018: Death Studies
https://www.readbyqxmd.com/read/29756070/reducing-severe-hypoglycaemia-in-hospitalised-patients-with-diabetes-early-outcomes-of-standardised-reporting-and-management
#6
Katherine A Araque, Deepak K Kadayakkara, Nino Gigauri, Diane Sheehan, Sachin Majumdar, Gregory Buller, Clare A Flannery
Background: Severe hypoglycaemic events (HGEs) in hospitalised patients are associated with poor outcomes and prolonged hospitalization. Systematic, coordinated care is required for acute management and prevention of HGEs; however, studies evaluating quality control efforts are scarce. Objective: To investigate the effectiveness of system-based interventions to improve management response to HGEs. Methods: System-based interventions were designed and implemented following a root cause analysis of HGE in adult patients with diabetes from two general medical wards with the highest incidence of HGE...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29754636/outcomes-of-pituitary-radiation-for-cushing-s-disease
#7
REVIEW
Natasha Ironside, Ching-Jen Chen, Cheng-Chia Lee, Daniel M Trifiletti, Mary Lee Vance, Jason P Sheehan
Achievement of biochemical remission with preservation of normal pituitary function is the goal of treatment for Cushing's disease. For patients with persistent or recurrent Cushing's disease after transsphenoidal resection, radiation therapy may be a safe and effective treatment. Stereotactic radiosurgery is favored over conventional fractionated external beam radiation. Hormonal recurrence rates range from 0% to 36% at 8 years after treatment. Tumor control rates are high. New pituitary hormone deficiency is the most common adverse effect after stereotactic radiosurgery and external beam radiation...
June 2018: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/29746723/postincident-support-for-healthcare-workers-experiencing-occupational-violence-and-aggression
#8
Tracey Shea, Brian Cooper, Helen De Cieri, Cathy Sheehan, Ross Donohue, Sarah Lindsay
PURPOSE: To investigate the relative contributions of workplace type, occupational violence and aggression (OVA) strategies and interventions along with perceptions of the occupational health and safety (OHS) environment on the likelihood of receiving postincident support following the experience of OVA. DESIGN: We used a cross-sectional study design with an online survey to collect data from employees in nursing and midwifery in Victoria, Australia. METHODS: Survey data collected from 3,072 members of the Australian Nursing and Midwifery Federation (Victorian branch) were analyzed using logistic regression...
May 10, 2018: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/29742589/clinical-factors-associated-with-icu-specific-care-following-supratentoral-brain-tumor-resection-and-validation-of-a-risk-prediction-score
#9
Lynze R Franko, Todd Hollon, Joseph Linzey, Christopher Roark, Venkatakrishna Rajajee, Kyle Sheehan, Magnus Teig, Shawn Hervey-Jumper, Jason Heth, Daniel Orringer, Craig A Williamson
OBJECTIVES: The postoperative management of patients who undergo brain tumor resection frequently occurs in an ICU. However, the routine admission of all patients to an ICU following surgery is controversial. This study seeks to identify the frequency with which patients undergoing elective supratentorial tumor resection require care, aside from frequent neurologic checks, that is specific to an ICU and to determine the frequency of new complications during ICU admission. Additionally, clinical predictors of ICU-specific care are identified, and a scoring system to discriminate patients most likely to require ICU-specific treatment is validated...
May 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29741416/does-the-functional-form-of-the-association-between-education-and-mortality-differ-by-u-s-region
#10
Connor Sheehan, Jennifer Karas Montez, Isaac Sasson
To understand the education-mortality association among U.S. adults, recent studies have documented its national functional form. However, the functional form of education-mortality relationship may vary across geographic contexts. The four U.S. Census regions differ considerably in their social and economic policies, employment opportunities, income levels, and other factors that may affect how education lowers the risk of mortality. Thus, we documented regional differences in the functional form of the education-mortality association and examined the role of employment and income in accounting for regional differences...
January 2018: Biodemography and Social Biology
https://www.readbyqxmd.com/read/29736895/cost-effectiveness-of-biological-asthma-treatments-a-systematic-review-and-recommendations-for-future-economic-evaluations
#11
REVIEW
R Brett McQueen, Danielle N Sheehan, Melanie D Whittington, Job F M van Boven, Jonathan D Campbell
BACKGROUND: Recently developed asthma biological therapies have been shown to provide relief for severe asthma patients not controlled by inhaled treatment. Given the relatively high costs of biological therapies, cost-effectiveness analyses (CEAs) may be required as a prerequisite for coverage and reimbursement. OBJECTIVE: We aimed to systematically review published literature on the economic impact of biological asthma therapies and to identify key drivers that impact cost-effectiveness in order to provide recommendations for future economic evaluations...
May 8, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29729811/a-multicenter-program-to-implement-the-canadian-c-spine-rule-by-emergency-department-triage-nurses
#12
Ian G Stiell, Catherine M Clement, Maureen Lowe, Connor Sheehan, Jacqueline Miller, Sherry Armstrong, Brenda Bailey, Kerry Posselwhite, Jannick Langlais, Karin Ruddy, Susan Thorne, Alison Armstrong, Catherine Dain, Jeffrey J Perry, Christian Vaillancourt
STUDY OBJECTIVE: The Canadian C-Spine Rule has been widely applied by emergency physicians to safely reduce use of cervical spine imaging. Our objective is to evaluate the clinical effect and safety of real-time Canadian C-Spine Rule implementation by emergency department (ED) triage nurses to remove cervical spine immobilization. METHODS: We conducted this multicenter, 2-phase, prospective cohort program at 9 hospital EDs and included alert trauma patients presenting with neck pain or with cervical spine immobilization...
May 2, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29724229/financial-management-of-large-multi-center-trials-in-a-challenging-funding-milieu
#13
Olivia Lovegreen, Danielle Riggs, Myrlene A Staten, Patricia Sheehan, Anastassios G Pittas
BACKGROUND: Randomized clinical trials that have public health implications but no or low potential for commercial gain are predominantly funded by governmental (e.g., National Institutes of Health (NIH)) and not-for-profit organizations. Our objective was to develop an alternative clinical trial site funding model for judicious allocation of declining public research funds. METHODS: In the Vitamin D and Type 2 Diabetes (D2d) study, an NIH-supported, large clinical trial testing the effect of vitamin D supplementation on incident diabetes in 2423 participants at high risk for diabetes, a hybrid financial management model for supporting collaborating clinical sites was developed and applied...
May 3, 2018: Trials
https://www.readbyqxmd.com/read/29720651/publisher-correction-adolescence-and-the-next-generation
#14
George C Patton, Craig A Olsson, Vegard Skirbekk, Richard Saffery, Mary E Wlodek, Peter S Azzopardi, Marcin Stonawski, Bruce Rasmussen, Elizabeth Spry, Kate Francis, Zulfiqar A Bhutta, Nicholas J Kassebaum, Ali H Mokdad, Christopher J L Murray, Andrew M Prentice, Nicola Reavley, Peter Sheehan, Kim Sweeny, Russell M Viner, Susan M Sawyer
In Fig. 4a of this Analysis, owing to an error during the production process, the year in the header of the right column was '2016' rather than '2010'. In addition, in the HTML version of the Analysis, Table 1 was formatted incorrectly. These errors have been corrected online.
May 2, 2018: Nature
https://www.readbyqxmd.com/read/29716807/endoport-assisted-surgical-evacuation-of-a-deep-seated-cerebral-abscess
#15
Shayan Moosa, Dale Ding, Panagiotis Mastorakos, Jason P Sheehan, Kenneth C Liu, Robert M Starke
Conventional surgical treatment for cerebral abscesses includes craniotomy or stereotactic aspiration. Deep-seated, large abscesses pose a challenge to neurosurgeons, due to the risk of injury to the cortex and white matter tracts secondary to the brain retraction necessary to access the lesion. The endoport is a tubular conduit that can be employed for minimally invasive approaches to deep-seated intracranial lesions, and it may reduce the length of dural opening, size of corticotomy, and retraction-related injury...
April 28, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29712829/correction-for-sheehan-et-al-coevolution-of-landesque-capital-intensive-agriculture-and-sociopolitical-hierarchy
#16
(no author information available yet)
No abstract text is available yet for this article.
April 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29712727/the-human-cathelicidin-antimicrobial-peptide-ll-37-promotes-the-growth-of-the-pulmonary-pathogen-aspergillus-fumigatus
#17
Gerard Sheehan, Gudmundur Bergsson, Noel G McElvaney, Emer P Reeves, Kevin Kavanagh
The pulmonary mucus of cystic fibrosis (CF) patients displays elevated levels of the cathelicidin antimicrobial peptide LL-37 and the aim of this work was to assess the effect of LL-37 on the growth of Aspergillus fumigatus , a common pathogen of CF patients. Exposure of A. fumigatus to LL-37 and its derived fragment RK-31 (1.95 μg/ml) for 24 hours had a positive effect on growth (199.94 ± 6.172%, p < 0.05) and (218.20 ± 4.63%, p < 0.05) respectively, whereas scrambled LL-37 peptide did not (85.12 ± 2...
April 30, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29705565/role-of-endocytotic-uptake-routes-in-impacting-the-ros-related-toxicity-of-silver-nanoparticles-to-mytilus-galloprovincialis-a-redox-proteomic-investigation
#18
Younes Bouallegui, Ridha Ben Younes, Ridha Oueslati, David Sheehan
Oxidative stress is often implicated in nanoparticle toxicity. Several studies have highlighted the role of internalization routes in determining nanotoxicity. Here, we investigate how two endocytotic mechanisms (clathrin- and caveolae-mediated) impact on redox balance in gill and digestive gland of the mussel, Mytilus galloprovincialis. Animals were exposed (for 3, 6 and 12 h) to two sizes of silver nanoparticles (AgNP: <50 nm and <100 nm) prior to and after blockade of two endocytic pathways (amantadine blocks clathrin-mediated endocytosis while nystatin blocks caveolae-mediated endocytosis)...
April 23, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29700167/moral-narcissism-and-moral-complicity-in-global-health-and-humanitarian-aid
#19
EDITORIAL
Mark Sheehan
No abstract text is available yet for this article.
May 2018: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29695407/healthcare-professionals-understanding-of-the-legislation-governing-research-involving-adults-lacking-mental-capacity-in-england-and-wales-a-national-survey
#20
Victoria Shepherd, Richard Griffith, Mark Sheehan, Fiona Wood, Kerenza Hood
OBJECTIVE: To examine health and social care professionals' understanding of the legislation governing research involving adults lacking mental capacity in England and Wales. METHODS: A cross-sectional online survey was conducted using a series of vignettes. Participants were asked to select the legally authorised decision-maker in each scenario and provide supporting reasons. Responses were compared with existing legal frameworks and analysed according to their level of concordance...
April 25, 2018: Journal of Medical Ethics
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