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https://www.readbyqxmd.com/read/28213602/understanding-the-epidemiology-of-avoidable-significant-harm-in-primary-care-protocol-for-a-retrospective-cross-sectional-study
#1
Brian G Bell, Stephen Campbell, Andrew Carson-Stevens, Huw Prosser Evans, Alison Cooper, Christina Sheehan, Sarah Rodgers, Christine Johnson, Adrian Edwards, Sarah Armstrong, Rajnikant Mehta, Antony Chuter, Ailsa Donnelly, Darren M Ashcroft, Joanne Lymn, Pam Smith, Aziz Sheikh, Matthew Boyd, Anthony J Avery
INTRODUCTION: Most patient safety research has focused on specialist-care settings where there is an appreciation of the frequency and causes of medical errors, and the resulting burden of adverse events. There have, however, been few large-scale robust studies that have investigated the extent and severity of avoidable harm in primary care. To address this, we will conduct a 12-month retrospective cross-sectional study involving case note review of primary care patients. METHODS AND ANALYSIS: We will conduct electronic searches of general practice (GP) clinical computer systems to identify patients with avoidable significant harm...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28211604/delays-in-treatment-intensification-with-oral-antidiabetic-drugs-and-risk-of-microvascular-and-macrovascular-events-in-patients-with-poor-glycemic-control-an-individual-patient-simulation-study
#2
Henry J Folse, Jayanti Mukherjee, John J Sheehan, Alexandra J Ward, Ryan L Pelkey, Tuan A Dinh, Lei Qin, Jennifer Kim
AIMS: Despite guideline recommendations, many patients with type 2 diabetes on oral antidiabetic drugs (OADs) whose HbA1c results remain above target do not experience timely treatment intensification. This study uses the Archimedes Model® to estimate the consequences of delays in OAD treatment intensification on glycemic control and long-term outcomes at 5 and 20 years. MATERIALS AND METHODS: Using real world data, we modeled a cohort of hypothetical patients with HbA1c ≥8%, on metformin, with no history of insulin use...
February 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28210881/comprehensive-genomic-profiling-of-malignant-phyllodes-tumors-of-the-breast
#3
Sahar Nozad, Christine E Sheehan, Laurie M Gay, Julia A Elvin, Jo-Anne Vergilio, James Suh, Shakti Ramkissoon, Alexa B Schrock, Kim M Hirshfield, Nadia Ali, Shridar Ganesan, Siraj M Ali, Vincent A Miller, Philip J Stephens, Jeffrey S Ross, Jon H Chung
PURPOSE: Malignant phyllodes tumors (MPT) are exceptionally rare, and the genomic drivers of these tumors are still being elucidated. We performed comprehensive genomic profiling (CGP) of MPT to identify genomic alterations that will inform approaches to targeted therapy for patients with MPT, including relapsed, refractory, and metastatic disease. METHODS: DNA was extracted from formalin-fixed, paraffin-embedded samples from 24 consecutive patient cases of MPT...
February 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28210658/patellar-maltracking-persists-in-adolescent-females-with-patellofemoral-pain-a-longitudinal-study
#4
Victor R Carlson, Barry P Boden, Aricia Shen, Jennifer N Jackson, Katharine E Alter, Frances T Sheehan
BACKGROUND: Patellofemoral pain is one of the most common conditions seen in sports medicine practices, particularly among adolescent females. However, the natural history of the underlying pathology in patellofemoral pain during puberty remains poorly understood. PURPOSE: The purpose of this longitudinal study is to assess changes in patellar maltracking patterns in subjects with patellofemoral pain as they mature from mid- to late adolescence. STUDY DESIGN: Cohort study; Level of evidence, 3...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28207596/a-role-for-adrenergic-receptors-in-the-uterotonic-effects-of-ergometrine-in-isolated-human-term-nonlaboring-myometrium
#5
Rebecca A Fanning, Florike Sheehan, Claire Leyden, Niamh Duffy, Luis F Iglesias-Martinez, Michael F Carey, Deirdre P Campion, John J O'Connor
BACKGROUND: Ergometrine is a uterotonic agent that is recommended in the prevention and management of postpartum hemorrhage. Despite its long-standing use, the mechanism by which it acts in humans has never been elucidated fully. The objective of this study was to investigate the role of adrenoreceptors in ergometrine's mechanism of action in human myometrium. The study examined the hypothesis that α-adrenoreceptor antagonism would result in the reversal of the uterotonic effects of ergometrine...
February 15, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28203368/a-nationwide-survey-of-anthelmintic-treatment-failure-on-sheep-farms-in-ireland
#6
Jason D Keegan, Orla M Keane, Barbara Good, Theo De Waal, Marian Denny, James P Hanrahan, William Fitzgerald, Maresa Sheehan
BACKGROUND: Between 2013 and 2015 the Department of Agriculture, Food and the Marine (DAFM) administered a sheep technology adoption programme (STAP), with the aim of increasing profitability on Irish sheep farms by encouraging the adoption of best management practices. One of the options available to STAP participants was to test the efficacy of the anthelmintic treatment (benzimadazole, levamisole or macrocyclic lactone) used in their flocks by means of a drench test, which is a modification of the faecal egg count reduction test; individual faecal samples were collected from the same group of lambs before and after anthelmintic treatment, the number of eggs present pre and post treatment was subsequently determined from a pooled sample...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28198351/therapeutic-drug-monitoring-guided-raltegravir-dosing-for-prevention-of-vertical-transmission-in-a-premature-neonate-born-to-a-woman-living-with-perinatally-acquired-hiv
#7
Denise Kreutzwiser, Nancy Sheehan, Natalie Dayneka, Benoît Lemire, Alison Wong, Lindy Samson, Jason Brophy
We report a case of therapeutic drug monitoring guided raltegravir use for the prevention of vertical HIV transmission in a premature neonate born to a woman living with perinatally acquired HIV and documented resistance to multiple HIV drugs. Maternal viral load was above 1,000 copies/mL at delivery. This case demonstrates delayed raltegravir elimination in a neonate born at 33 weeks gestational age and a need for less frequent raltegravir dosing than is used in older infants and children.
February 15, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28192732/reproductive-decisions-after-the-diagnosis-of-amniotic-fluid-embolism
#8
Amirhossein Moaddab, Miranda Klassen, Cynthia D Priester, Elvira H Munoz, Michael A Belfort, Steven L Clark, Gary A Dildy
OBJECTIVE: This study aims to describe the subsequent reproductive outcomes in women who either correctly or incorrectly were diagnosed with amniotic fluid embolism (AFE). STUDY DESIGN: Medical records were obtained, abstracted and reviewed by authors with extensive experience in critical care obstetrics. Telephone interviews of all survivors were conducted to determine obstetrical and contraceptive history. A subgroup underwent further telephone interview to address subsequent reproductive decisions...
January 23, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28181109/a-retrospective-review-of-farm-injuries-presenting-to-an-irish-hospital-emergency-department-in-2013
#9
A Abdulkarim, P Carroll, P Coffey, E Sheehan
BACKGROUND: The agricultural and equestrian businesses are an important source of employment in the Midlands. This is a retrospective study examining the demographics, characteristics, and outcomes of agricultural and equestrian related injuries presenting to the Midland Regional Hospital, Tullamore, Co. Offaly. There were a total of 30,700 attendances to the Emergency Department for 2013. AIMS: This study is an epidemiological review of agricultural injuries, their mechanisms, and consequences presenting to a rural regional hospital over a 1 year period...
February 8, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28175550/205%C3%A2-tractography-characterizing-lesions-differentiating-responders-to-stereotactic-capsulotomy-for-obsessive-compulsive-disorder
#10
Pranav Nanda, Garrett P Banks, Yagna Pathak, Danika L Paulo, Guillermo Horga, Marcelo Q Hoexter, Zhiyuan Xu, Antonio Lopes, Nicole McLaughlin, Benjamin Greenberg, Jason P Sheehan, Euripides C Miguel, Sameer A Sheth
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175493/306%C3%A2-worse-stereotactic-radiosurgery-outcomes-for-intracranial-arteriovenous-malformations-after-repeat-vs-initial-treatment-a-matched-cohort-study
#11
Dale Ding, Zhiyuan Xu, Han-Hsun Shih, Robert M Starke, Chun-Po Yen, Or Cohen-Inbar, Jason P Sheehan
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175485/156%C3%A2-effect-of-associated-arterial-aneurysms-on-outcomes-after-stereotactic-radiosurgery-for-intracranial-arteriovenous-malformations-a-matched-cohort-study
#12
Dale Ding, Zhiyuan Xu, Robert M Starke, Chun-Po Yen, Han-Hsun Shih, Thomas Buell, Jason P Sheehan
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175377/112%C3%A2-stereotactic-radiosurgery-for-intracranial-arteriovenous-malformations-with-intranidal-and-prenidal-arterial-aneurysms
#13
Dale Ding, Zhiyuan Xu, Robert M Starke, Chun-Po Yen, Han-Hsun Shih, Thomas Buell, Jason P Sheehan
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28166431/change-of-hba1c-associated-with-treatment-intensification-among-patients-with-type-2-diabetes-and-poor-glycemic-control
#14
Alex Z Fu, John J Sheehan
OBJECTIVE: We conducted a retrospective cohort study to investigate the HbA1c change associated with treatment intensification in a real-world population of patients with type 2 diabetes (T2D). METHODS: Using a large U.S. insurance claims database, patients aged ≥18 years with a T2D diagnosis and HbA1c ≥8.0% (64 mmol/mol) after ≥3 months of oral pharmacotherapy with metformin (± other oral antidiabetes agents) were identified (index date). Continuous enrollment was required for ≥12 months before (baseline) and after the index date with no baseline use of injectable antidiabetes drugs...
February 6, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28165862/no-one-saw-this-coming-endoparasitic-mites-behind-the-eyes-of-a-double-crested-cormorant
#15
Kate L Sheehan, Greg S Spicer, Barry M OConnor, Ryan F Hechinger
We found hundreds of mites behind the eyes of a Double-crested Cormorant, Phalacrocorax auritus (Suliformes: Phalacrocoracidae). The mites were Neottialges evansi (Acari: Hypoderatidae), representing the first report of this parasite in P. auritus from western North America. Deutonymphs of N. evansi are endoparasites, typically reported infecting fat deposits over the pectoral muscles, axillary areas, and vent of cormorants. Here, mites infected only orbital tissues, a new infection site for hypoderatid mites...
February 6, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28165209/responsiveness-to-difference-ada-accommodations-in-the-course-of-an-arrest
#16
Robyn Levin
When the Supreme Court heard argument in City & County of San Francisco v. Sheehan in the spring of 2015, it intended to resolve a circuit split. In granting certiorari, the Court planned to clarify whether individuals with disabilities can sue police officers under the ADA if an officer fails to accommodate a disability in the course of an arrest. However, because the petitioners failed to brief the Court on that question, the portion of the case involving the ADA was dismissed as improvidently granted. Justices Scalia and Kagan were so enraged by the failure to brief on the "certworthy" question that they issued a partial dissent, refusing to issue opinions on any of the attendant issues...
January 2017: Stanford Law Review
https://www.readbyqxmd.com/read/28165006/axon-degeneration-induces-glial-responses-through-draper-traf4-jnk-signalling
#17
Tsai-Yi Lu, Jennifer M MacDonald, Lukas J Neukomm, Amy E Sheehan, Rachel Bradshaw, Mary A Logan, Marc R Freeman
Draper/Ced-1/MEGF-10 is an engulfment receptor that promotes clearance of cellular debris in C. elegans, Drosophila and mammals. Draper signals through an evolutionarily conserved Src family kinase cascade to drive cytoskeletal rearrangements and target engulfment through Rac1. Glia also alter gene expression patterns in response to axonal injury but pathways mediating these responses are poorly defined. We show Draper is cell autonomously required for glial activation of transcriptional reporters after axonal injury...
February 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28164847/the-gut-microbiota-in-inflammatory-bowel-disease
#18
REVIEW
Donal Sheehan, Fergus Shanahan
Genes, bacteria, and immunity contribute to the pathogenesis of inflammatory bowel disease. Most genetic risk relates to defective sensing of microbes and their metabolites or defective regulation of the host response to the microbiota. Because the composition of the microbiota shapes the developing immune system and is determined in early life, the prospect of therapeutic manipulation of the microbiota in adulthood after the onset of disease is questionable. However, the microbiota may be a marker of risk and a modifier of disease activity and a contributor to extraintestinal manifestations and associations in some patients with inflammatory bowel disease...
March 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28163365/recruiting-and-assessing-recent-young-adult-latina-immigrants-in-health-disparities-research
#19
Diana M Sheehan, Frank R Dillon, Rosa Babino, James Melton, Christine Spadola, Nicole Da Silva, Mario De La Rosa
The authors interviewed 4 researchers to identify facilitators in recruiting and assessing Latina immigrants. The 4 researchers recruited 530 recent Latina immigrants (ages 18-23 years) for a study of social and cultural determinants of health. Consensual qualitative research methods revealed that respondent-driven sampling was an effective recruitment method. Fear of deportation was a barrier. Stigma about sensitive topics (e.g., sex, drug use) did not affect participation. Findings can help counselors conduct health disparities research...
October 2016: Journal of Multicultural Counseling and Development
https://www.readbyqxmd.com/read/28159645/driven-to-distraction-the-nature-and-apparent-purpose-of-interruptions-in-critical-care-and-implications-for-hit
#20
Lena Mamykina, Eileen J Carter, Barbara Sheehan, R Stanley Hum, Bridget C Twohig, David R Kaufman
OBJECTIVES: To examine the apparent purpose of interruptions in a Pediatric Intensive Care Unit and opportunities to reduce their burden with informatics solutions. MATERIALS AND METHODS: In this prospective observational study, researchers shadowed clinicians in the unit for one hour at a time, recording all interruptions participating clinicians experienced or initiated, their starting time, duration, and a short description that could help to infer their apparent purpose...
January 31, 2017: Journal of Biomedical Informatics
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