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https://www.readbyqxmd.com/read/28913704/impact-of-etiology-age-and-gender-on-onset-and-severity-of-hyponatremia-in-patients-with-hypopituitarism-retrospective-analysis-in-a-specialised-endocrine-unit
#1
Dragana Miljic, Mirjana Doknic, Marko Stojanovic, Marina Nikolic-Djurovic, Milan Petakov, Vera Popovic, Sandra Pekic
BACKGROUND: Hyponatremia can unmask hypopituitarism and secondary adrenal insufficiency. This is important, since the need to screen for steroid deficiency, in patients with hyponatremia is often neglected. PATIENTS AND METHODS: In a retrospective study, twenty-five patients (13f/12m, age 58.9 ± 18.6 years) with hyponatremia (119.7 ± 10.5 mmol/L) were identified among 260 in-patients treated for hypopituitarism in our specialized endocrine unit, over the last decade...
September 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28913674/prognostic-significance-of-corticotroph-staining-in-radiosurgery-for-non-functioning-pituitary-adenomas-a-multicenter-study
#2
Or Cohen-Inbar, Zhiyuan Xu, Cheng-Chia Lee, Chin-Chun Wu, Tomáš Chytka, Danilo Silva, Mayur Sharma, Hesham Radwan, Inga S Grills, Brandon Nguyen, Zaid Siddiqui, David Mathieu, Christian Iorio-Morin, Amparo Wolf, Christopher P Cifarelli, Daniel T Cifarelli, L Dade Lunsford, Douglas Kondziolka, Jason P Sheehan
Silent corticotroph staining pituitary adenoma (SCA) represents an uncommon subset of Non-Functioning adenomas (NFAs), hypothesized to be more locally aggressive. In this retrospective multicenter study, we investigate the safety and effectiveness of Stereotactic Radiosurgery (SRS) in patients with SCA compared with other non-SCA NFA's. Eight centers participating in the International Gamma-Knife Research Foundation (IGKRF) contributed to this study. Outcomes of 50 patients with confirmed SCAs and 307 patients with confirmed non-SCA NFA's treated with SRS were evaluated...
September 14, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28906261/the-disability-impact-and-associated-cost-per-disability-in-women-who-underwent-surgical-revision-of-transvaginal-mesh-kits-for-prolapse-repair
#3
Pouya Javadian, S Abbas Shobeiri
OBJECTIVES: The aim of this study was to investigate disability impact in patients and cost to the families of patients who have had complications of transvaginal prolapse mesh kits and underwent surgical revision. METHODS: Patients who developed complications of transvaginal mesh kits for prolapse and who had undergone vaginal prolapse mesh surgical revision/removal in 2009 to 2014 at a single institution were identified by Current Procedural Terminology codes...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28902493/direct-synthesis-of-alloyed-si1-xgex-nanowires-for-performance-tunable-lithium-ion-battery-anodes
#4
Killian Stokes, Hugh Geaney, Grace Flynn, Martin Sheehan, Tadhg Kennedy, Kevin M Ryan
Here we report the formation of high capacity Li-ion battery anodes from Si1-xGex alloy nanowire arrays that are grown directly on stainless steel current collectors, in a single step synthesis. The direct formation of these Si1-xGex nanowires (ranging from Si0.20Ge0.80 to Si0.67Ge0.33) represents a simple and efficient processing route for the production of Li-ion battery anodes possessing the benefits of both Si (high capacity) and Ge (improved rate performance and capacity retention). The nanowires were characterized through SEM, TEM, XRD and ex-situ HRSEM/HRTEM...
September 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28901654/clinical-learning-environments-place-artefacts-and-rhythm
#5
Dale Sheehan, Tanisha Jowsey, Mariam Parwaiz, Mark Birch, Philippa Seaton, Susan Shaw, Alison Duggan, Tim Wilkinson
CONTEXT: Health care practitioners learn through experience in clinical environments in which supervision is a key component, but how that learning occurs outside the supervision relationship remains largely unknown. This study explores the environmental factors that inform and support workplace learning within a clinical environment. METHODS: An observational study drawing on ethnographic methods was undertaken in a general medicine ward. Observers paid attention to interactions among staff members that involved potential teaching and learning moments that occurred and were visible in the course of routine work...
October 2017: Medical Education
https://www.readbyqxmd.com/read/28899030/mooney-et-al-respond-to-observing-neighborhood-physical-disorder
#6
Stephen J Mooney, Michael D M Bader, Gina S Lovasi, Julien O Teitler, Karestan C Koenen, Allison E Aiello, Sandro Galea, Emily Goldmann, Daniel M Sheehan, Andrew G Rundle
No abstract text is available yet for this article.
August 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28899028/street-audits-to-measure-neighborhood-disorder-virtual-or-in-person
#7
Stephen J Mooney, Michael D M Bader, Gina S Lovasi, Julien O Teitler, Karestan C Koenen, Allison E Aiello, Sandro Galea, Emily Goldmann, Daniel M Sheehan, Andrew G Rundle
Neighborhood conditions may influence a broad range of health indicators, including obesity, injury, and psychopathology. In particular, neighborhood physical disorder-a measure of urban deterioration-is thought to encourage crime and high-risk behaviors, leading to poor mental and physical health. In studies to assess neighborhood physical disorder, investigators typically rely on time-consuming and expensive in-person systematic neighborhood audits. We compared 2 audit-based measures of neighborhood physical disorder in the city of Detroit, Michigan: One used Google Street View imagery from 2009 and the other used an in-person survey conducted in 2008...
August 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28891017/re-appraisal-of-estrogen-receptor-negative-progesterone-receptor-positive-er-pr-breast-cancer-phenotype-true-subtype-or-technical-artefact
#8
Niamh M Foley, J M Coll, A J Lowery, S O Hynes, M J Kerin, M Sheehan, C Brodie, K J Sweeney
Expression of the ER and PR receptors is routinely quantified in breast cancer as a predictive marker of response to hormonal therapy. Accurate determination of ER and PR status is critical to the optimal selection of patients for targeted therapy. The existence of an ER-/PR+ subtype is controversial, with debate centred on whether this represents a true phenotype or a technical artefact on immunohistochemistry (IHC). The aim of this study was to investigate the true incidence and clinico-pathological features of ER-/PR+ breast cancers in a tertiary referral symptomatic breast unit...
September 11, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28888041/supplementation-with-the-methyl-donor-betaine-prevents-congenital-defects-induced-by-prenatal-alcohol-exposure
#9
Ganga Karunamuni, Megan M Sheehan, Yong Qiu Doughman, Shi Gu, Jiayang Sun, Youjun Li, James P Strainic, Andrew M Rollins, Michael W Jenkins, Michiko Watanabe
BACKGROUND: Despite decades of public education about dire consequences of prenatal alcohol exposure, drinking alcohol during pregnancy remains prevalent. As high as 40% of live-born infants exposed to alcohol during gestation and diagnosed with Fetal Alcohol Syndrome have congenital heart defects that can be life-threatening. In animal models, the methyl donor betaine, found in foods such as wheat bran, quinoa, beets and spinach, ameliorated neurobehavioral deficits associated with prenatal alcohol exposure (PAE) but effects on heart development are unknown...
September 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28885118/stereotactic-radiosurgery-for-spetzler-martin-grade-iv-and-v-arteriovenous-malformations-an-international-multicenter-study
#10
Mohana Rao Patibandla, Dale Ding, Hideyuki Kano, Zhiyuan Xu, John Y K Lee, David Mathieu, Jamie Whitesell, John T Pierce, Paul P Huang, Douglas Kondziolka, Caleb Feliciano, Rafael Rodriguez-Mercado, Luis Almodovar, Inga S Grills, Danilo Silva, Mahmoud Abbassy, Symeon Missios, Gene H Barnett, L Dade Lunsford, Jason P Sheehan
OBJECTIVE Due to the complexity of Spetzler-Martin (SM) Grade IV-V arteriovenous malformations (AVMs), the management of these lesions remains controversial. The aims of this multicenter, retrospective cohort study were to evaluate the outcomes after single-session stereotactic radiosurgery (SRS) for SM Grade IV-V AVMs and determine predictive factors. METHODS The authors retrospectively pooled data from 233 patients (mean age 33 years) with SM Grade IV (94.4%) or V AVMs (5.6%) treated with single-session SRS at 8 participating centers in the International Gamma Knife Research Foundation...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28882711/stereotactic-radiosurgery-of-central-skull-base-meningioma-s-volumetric-evaluation-and-long-term-outcomes
#11
Mohana Rao Patibandla, Cheng-Chia Lee, Jason Sheehan
BACKGROUND AND OBJECTIVE: Central skull base meningioma's (CSMs) complete resection is possible but it is often associated with high morbidity. Stereotactic radiosurgery (SRS) plays an appreciable role in the management of skull base meningiomas. The study aims to apply volumetric methods to assess CSM response after SRS and correlate with clinical outcomes. MATERIALS AND METHODS: The cohort consisted of 219 patients, of whom 73.9% were female (n=162), with a median age of 55 years (19-88)...
September 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28873162/mutation-detection-in-patients-with-advanced-cancer-by-universal-sequencing-of-cancer-related-genes-in-tumor-and-normal-dna-vs-guideline-based-germline-testing
#12
Diana Mandelker, Liying Zhang, Yelena Kemel, Zsofia K Stadler, Vijai Joseph, Ahmet Zehir, Nisha Pradhan, Angela Arnold, Michael F Walsh, Yirong Li, Anoop R Balakrishnan, Aijazuddin Syed, Meera Prasad, Khedoudja Nafa, Maria I Carlo, Karen A Cadoo, Meg Sheehan, Megan H Fleischut, Erin Salo-Mullen, Magan Trottier, Steven M Lipkin, Anne Lincoln, Semanti Mukherjee, Vignesh Ravichandran, Roy Cambria, Jesse Galle, Wassim Abida, Marcia E Arcila, Ryma Benayed, Ronak Shah, Kenneth Yu, Dean F Bajorin, Jonathan A Coleman, Steven D Leach, Maeve A Lowery, Julio Garcia-Aguilar, Philip W Kantoff, Charles L Sawyers, Maura N Dickler, Leonard Saltz, Robert J Motzer, Eileen M O'Reilly, Howard I Scher, Jose Baselga, David S Klimstra, David B Solit, David M Hyman, Michael F Berger, Marc Ladanyi, Mark E Robson, Kenneth Offit
Importance: Guidelines for cancer genetic testing based on family history may miss clinically actionable genetic changes with established implications for cancer screening or prevention. Objective: To determine the proportion and potential clinical implications of inherited variants detected using simultaneous sequencing of the tumor and normal tissue ("tumor-normal sequencing") compared with genetic test results based on current guidelines. Design, Setting, and Participants: From January 2014 until May 2016 at Memorial Sloan Kettering Cancer Center, 10 336 patients consented to tumor DNA sequencing...
September 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28872999/analysis-of-the-early-cellular-and-humoral-responses-of-galleria-mellonella-larvae-to-infection-by-candida-albicans
#13
Gerard Sheehan, Kevin Kavanagh
Galleria mellonella larvae were administered an inoculum of Candida albicans and the response to infection over 24 hours was monitored. The yeast cell density in infected larvae declined initially but replication commenced six hours post-infection. The hemocyte density decreased from 5.2 × 106/ml to 2.5 × 106/ml at 2 hours but increased to 4.2 × 106 at 6 hours and decreased subsequently. Administration of β - glucan to larvae also caused a fluctuation in hemocyte density (5.1 ± 0.22 × 106/ml (0 hour) to 6...
September 5, 2017: Virulence
https://www.readbyqxmd.com/read/28866073/national-trends-in-radiotherapy-for-brain-metastases-at-time-of-diagnosis-of-non-small-cell-lung-cancer
#14
Daniel M Trifiletti, Jason P Sheehan, Surbhi Grover, Sunil W Dutta, Chad G Rusthoven, Brian D Kavanagh, Arjun Sahgal, Timothy N Showalter
BACKGROUND: To analyze the national trends of patients treated radiotherapy for brain metastases from non-small cell lung cancer (NSCLC) that were found at diagnosis. METHODS: The National Cancer Database was queried for patients with NSCLC diagnosed from 2004 to 2013 that received brain irradiation for metastases and patients grouped into having had received fractionated brain radiotherapy (5-15 fractions with or without radiosurgery) or intracranial radiosurgery alone (1-5 fractions)...
August 30, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28862549/outcomes-of-stereotactic-radiosurgery-for-foramen-magnum-meningiomas-an-international-multicenter-study
#15
Gautam U Mehta, Georgios Zenonos, Mohana Rao Patibandla, Chung Jung Lin, Amparo Wolf, Inga Grills, David Mathieu, Brendan McShane, John Y Lee, Kevin Blas, Douglas Kondziolka, Cheng-Chia Lee, L Dade Lunsford, Jason P Sheehan
OBJECTIVE Meningiomas are the most common benign extramedullary lesions of the foramen magnum; however, their optimal management remains undefined. Given their location, foramen magnum meningiomas (FMMs) can cause significant morbidity, and complete microsurgical removal can be challenging. Anterior and anterolateral FMMs carry greater risks with surgery, but they comprise the majority of these lesions. As an alternative to resection, stereotactic radiosurgery (SRS) has been used to treat FMMs in small case series...
September 1, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28859561/psychosurgery-ethics-and-media-a-history-of-walter-freeman-and-the-lobotomy
#16
James P Caruso, Jason P Sheehan
At the peak of his career, Walter J. Freeman II was a celebrated physician and scientist. He served as the first chairman of the Department of Neurology at George Washington University and was a tireless advocate of surgical treatment for mental illness. His eccentric appearance, engaging personality during interviews, and theatrical demonstrations of his surgical techniques gained him substantial popularity with local and national media, and he performed more than 3000 prefrontal and transorbital lobotomies between 1930 and 1960...
September 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28858412/a-randomized-double-blind-placebo-controlled-8-week-trial-of-the-efficacy-safety-and-tolerability-of-5-10-and-20-mg-day-vortioxetine-in-adults-with-major-depressive-disorder
#17
Akira Nishimura, Yutaka Aritomi, Kiyofumi Sasai, Tadayuki Kitagawa, Atul R Mahableshwarkar
AIM: This study assessed the efficacy and safety of vortioxetine in adults with major depressive disorder. METHODS: In this double-blind, placebo-controlled study, 600 patients with major depressive disorder were randomly assigned (1:1:1:1) to receive vortioxetine 5, 10, or 20 mg, or placebo once daily for 8 weeks. The primary endpoint was change from baseline in Montgomery-Åsberg Depression Rating Scale total score at week 8, evaluated by the last observation carried forward method...
August 31, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28854601/large-scale-identification-of-wolbachia-pipientis-effectors
#18
Danny W Rice, Kathy B Sheehan, Irene L G Newton
Wolbachia pipientis is an intracellular symbiont of arthropods well known for the reproductive manipulations induced in the host and, more recently, for the ability of Wolbachia to block virus replication in insect vectors. Since Wolbachia cannot yet be genetically manipulated, and due to the constraints imposed when working with an intracellular symbiont, little is known about mechanisms used by Wolbachia for host interaction. Here we employed a bioinformatics pipeline and identified 163 candidate effectors, potentially secreted by Wolbachia into the host cell...
July 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28827264/patient-and-system-factors-of-time-to-surgery-after-hip-fracture-a-scoping-review
#19
Katie J Sheehan, Boris Sobolev, Yuri F Villán Villán, Pierre Guy
OBJECTIVES: It is disputed whether the time a patient waits for surgery after hip fracture increases the risk of in-hospital death. This uncertainty matters as access to surgery following hip fracture may be underprioritised due to a lack of definitive evidence. Uncertainty in the available evidence may be due to differences in characteristics of patients, their injury and their care. We summarised the literature on patients and system factors associated with time to surgery, and collated proposed mechanisms for the associations...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28826915/the-gluten-free-diet-epidemic-socioeconomic-factors-predict-google-search-trends-more-than-health-related-factors
#20
Monika Laszkowska, Henna Shiwani, Julia Belluz, Jonas F Ludvigsson, Peter Hr Green, Daniel Sheehan, Andrew Rundle, Benjamin Lebwohl
No abstract text is available yet for this article.
August 4, 2017: Clinical Gastroenterology and Hepatology
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