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https://www.readbyqxmd.com/read/28433340/caregiver-stress-among-inner-city-school-children-with-asthma
#1
Lianne S Kopel, Carter R Petty, Jonathan M Gaffin, William J Sheehan, Sachin N Baxi, Watcharoot Kanchongkittiphon, Chunxia Fu, Diane R Gold, Wanda Phipatanakul
No abstract text is available yet for this article.
April 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28433259/building-the-foundations-for-sustainable-development-a-case-for-global-investment-in-the-capabilities-of-adolescents
#2
Peter Sheehan, Kim Sweeny, Bruce Rasmussen, Annababette Wils, Howard S Friedman, Jacqueline Mahon, George C Patton, Susan M Sawyer, Eric Howard, John Symons, Karin Stenberg, Satvika Chalasani, Neelam Maharaj, Nicola Reavley, Hui Shi, Masha Fridman, Alison Welsh, Emeka Nsofor, Laura Laski
Investment in the capabilities of the world's 1·2 billion adolescents is vital to the UN's Sustainable Development Agenda. We examined investments in countries of low income, lower-middle income, and upper-middle income covering the majority of these adolescents globally to derive estimates of investment returns given existing knowledge. The costs and effects of the interventions were estimated by adapting existing models and by extending methods to create new modelling tools. Benefits were valued in terms of increased gross domestic product and averted social costs...
April 19, 2017: Lancet
https://www.readbyqxmd.com/read/28431024/radiosurgery-for-unruptured-brain-arteriovenous-malformations-an-international-multicenter-retrospective-cohort-study
#3
Dale Ding, Robert M Starke, Hideyuki Kano, John Y K Lee, David Mathieu, John Pierce, Paul Huang, Symeon Missios, Caleb Feliciano, Rafael Rodriguez-Mercado, Luis Almodovar, Inga S Grills, Danilo Silva, Mahmoud Abbassy, Douglas Kondziolka, Gene H Barnett, L Dade Lunsford, Jason P Sheehan
BACKGROUND: The role of intervention in the management of unruptured brain arteriovenous malformations (AVM) is controversial. OBJECTIVE: To analyze in a multicenter, retrospective cohort study, the outcomes following radiosurgery for unruptured AVMs and determine predictive factors. METHODS: We evaluated and pooled AVM radiosurgery data from 8 institutions participating in the International Gamma Knife Research Foundation. Patients with unruptured AVMs and ≥12 mo of follow-up were included in the study cohort...
April 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28430737/laser-hair-removal-in-alopecia-areata-of-the-scalp-a-novel-therapeutic-approach
#4
Geoffrey Brent, Bevin Bhoyrul, Rob Sheehan-Dare
No abstract text is available yet for this article.
April 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28427986/prognostic-implications-of-extent-of-resection-in-glioblastoma-analysis-from-a-large-database
#5
Daniel M Trifiletti, Clayton Alonso, Surbhi Grover, Camilo E Fadul, Jason P Sheehan, Timothy N Showalter
OBJECTIVE: To analyze the predictors for and clinical impact of gross total resection (GTR) in patients with glioblastoma (GBM). METHODS AND MATERIALS: The National Cancer Database was queried for patients with GBM diagnosed from 2004-2013 with known survival and extent of resection. Patients were grouped based on extent of resection into biopsy alone, subtotal resection (STR), and GTR. Univariable and multivariable (MVA) analyses were performed to investigate factors associated with the likelihood of GTR and overall survival (OS) following diagnosis...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28427539/the-role-of-serum-amyloid-a-staining-of-granulomatous-tissues-for-the-diagnosis-of-sarcoidosis
#6
Albert Huho, Llewellyn Foulke, Timothy Jennings, Efstratios Koutroumpakis, Siddhartha Dalvi, Haroon Chaudhry, Amit Chopra, Aakash Modi, Neha Rane, David J Prezant, Christine Sheehan, Recai Yucel, Mehul Patel, Marc A Judson
BACKGROUND: Previous studies demonstrated that SAA staining of sarcoidosis granulomas was qualitatively and quantitatively different from other granulomatous diseases. These data suggest that positive SAA staining of granulomatous tissue may have adequate specificity to establish a diagnosis of sarcoidosis. Our objective was to determine the diagnostic specificity of SAA staining for sarcoidosis relative to other granulomatous disorders. METHODS: Pathological specimens demonstrating granulomatous inflammation were retrospectively identified at one institution, plus 4 specimens were obtained from New York City firefighters with biopsy-confirmed World Trade Center "sarcoidosis-like" pulmonary disease...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28422882/hospital-mortality-after-hip-fracture-surgery-in-relation-to-length-of-stay-by-care-delivery-factors-a-database-study
#7
Boris Sobolev, Pierre Guy, Katie J Sheehan, Eric Bohm, Lauren Beaupre, Suzanne N Morin, Jason M Sutherland, Michael Dunbar, Donald Griesdale, Susan Jaglal, Lisa Kuramoto
Two hypotheses were offered for the effect of shorter hospital stays on mortality after hip fracture surgery: worsening the quality of care and shifting death occurrence to postacute settings.We tested whether the risk of hospital death after hip fracture surgery differed across years when postoperative stays shortened, and whether care factors moderated the association.Analysis of acute hospital discharge abstracts for subgroups defined by hospital type, bed capacity, surgical volume, and admission time.153,917 patients 65 years or older surgically treated for first hip fracture...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28419810/the-relationship-of-static-tibial-tubercle-trochlear-groove-measurement-and-dynamic-patellar-tracking
#8
Victor R Carlson, Frances T Sheehan, Aricia Shen, Lawrence Yao, Jennifer N Jackson, Barry P Boden
BACKGROUND: The tibial tubercle to trochlear groove (TT-TG) distance is used for screening patients with a variety of patellofemoral joint disorders to determine who may benefit from patellar medialization using a tibial tubercle osteotomy. Clinically, the TT-TG distance is predominately based on static imaging with the knee in full extension; however, the predictive ability of this measure for dynamic patellar tracking patterns is unknown. PURPOSE: To determine whether the static TT-TG distance can predict dynamic lateral displacement of the patella...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28419621/the-feasibility-acceptability-and-outcomes-of-prime-d-a-novel-mobile-intervention-treatment-for-depression
#9
Danielle A Schlosser, Timothy R Campellone, Brandy Truong, Joaquin A Anguera, Silvia Vergani, Sophia Vinogradov, Patricia Arean
BACKGROUND: Despite decades of research and development, depression has risen from the fifth to the leading cause of disability in the United States. Barriers to progress in the field are (1) poor access to high-quality care; (2) limited mental health workforce; and (3) few providers trained in the delivery of evidence-based treatments (EBTs). Although mobile platforms are being developed to give consumers greater access to high-quality care, too often these tools do not have empirical support for their effectiveness...
April 18, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28414260/retention-in-hiv-care-and-viral-suppression-individual-and-neighborhood-level-predictors-of-racial-ethnic-differences-florida-2015
#10
Diana M Sheehan, Kristopher P Fennie, Daniel E Mauck, Lorene M Maddox, Spencer Lieb, Mary Jo Trepka
The objective of this study was to estimate racial/ethnic differences in retention in HIV care and viral suppression and to identify related individual and neighborhood determinants. Florida HIV surveillance records of cases aged ≥13 years diagnosed during the years 2000-2014 were analyzed. Retention in care was defined as evidence of ≥2 or more laboratory tests, receipts of prescription, or clinical visits at least 3 months apart during 2015. Viral load suppression was defined as a viral load of <200 copies/mL for the last test in 2015...
April 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28401650/caenorhabditis-elegans-orthologs-of-human-genes-differentially-expressed-with-age-are-enriched-for-determinants-of-longevity
#11
George L Sutphin, Grant Backer, Susan Sheehan, Shannon Bean, Caroline Corban, Teresa Liu, Marjolein J Peters, Joyce B J van Meurs, Joanne M Murabito, Andrew D Johnson, Ron Korstanje
We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published genomewide longevity screens in C. elegans and similar to screens that preselected candidates based on longevity-correlated metrics (e.g., stress resistance). Of the 50 genes that affected lifespan, 46 were previously unreported...
April 12, 2017: Aging Cell
https://www.readbyqxmd.com/read/28386452/heritable-variation-in-colour-patterns-mediating-individual-recognition
#12
Michael J Sheehan, Juanita Choo, Elizabeth A Tibbetts
Understanding the developmental and evolutionary processes that generate and maintain variation in natural populations remains a major challenge for modern biology. Populations of Polistes fuscatus paper wasps have highly variable colour patterns that mediate individual recognition. Previous experimental and comparative studies have provided evidence that colour pattern diversity is the result of selection for individuals to advertise their identity. Distinctive identity-signalling phenotypes facilitate recognition, which reduces aggression between familiar individuals in P...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28384483/adult-children-s-education-and-changes-to-parents-physical-health-in-mexico
#13
Jenjira J Yahirun, Connor M Sheehan, Mark D Hayward
The well-being of older adults is frequently tied to support from their adult children. Here, we assess whether the education of adult offspring is associated with changes to older parents' short- and long-term health in Mexico, a rapidly aging context with historically limited institutional support for the elderly. Educational expansion over the past half century, however, provides older adults with greater resources to rely on via the education of their children. Using longitudinal data from the Mexican Health and Aging Study (2001-2012), we find that offspring education is not associated with short-term changes in parents' physical functioning, but is associated with increased parental longevity, net of children's financial status and transfers...
May 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28383583/new-insights-into-polyene-macrolide-biosynthesis-in-couchioplanes-caeruleus
#14
J Sheehan, C D Murphy, P Caffrey
Couchioplanes caeruleus DSM43634 synthesises 67-121C, an aromatic heptaene macrolide that contains a mannosyl-mycosaminyl disaccharide. An improved draft genome sequence was used to obtain the biosynthetic gene cluster for this antifungal. Bioinformatic analysis of the polyketide synthase indicated that extension modules 7 and 8 contain A-type ketoreductase and dehydratase domains. These modules are therefore predicted to form cis double bonds. The deduced stereostructure of the 67-121C macrolactone is identical to that experimentally determined for the partricin subgroup of aromatic heptaenes...
April 6, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28382385/neighborhood-determinants-of-mood-and-anxiety-disorders-among-men-who-have-sex-with-men-in-new-york-city
#15
Magdalena Cerdá, Vijay Nandi, Victoria Frye, James E Egan, Andrew Rundle, James W Quinn, Daniel Sheehan, Donald R Hoover, Danielle C Ompad, Hong Van Tieu, Emily Greene, Beryl Koblin
PURPOSE: We examined the relationship between economic, physical, and social characteristics of neighborhoods, where men who have sex with men (MSM) lived and socialized, and symptom scores of depression and generalized anxiety disorder (GAD). METHODS: Participants came from a cross-sectional study of a population-based sample of New York City MSM recruited in 2010-2012 (n = 1126). Archival and survey-based data were obtained on neighborhoods, where the men lived and where they socialized most often...
April 5, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28379882/silexan-in-generalized-anxiety-disorder-investigation-of-the-therapeutic-dosage-range-in-a-pooled-data-set
#16
Siegfried Kasper, Hans-Jürgen Möller, Hans-Peter Volz, Sandra Schläfke, Angelika Dienel
Silexan, a special active substance produced from Lavandula angustifolia, is efficacious in subsyndromal anxiety at a dose of 80 mg/day, but its effective dosage in generalized anxiety disorder (GAD) has yet to be defined. In two double-blind, placebo-controlled trials, daily doses of 10, 40, 80, and 160 mg silexan were administered for 10 weeks. A total of 925 adults with GAD according to Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria and a Hamilton Anxiety Scale (HAMA) total score of at least 18 points were analyzed for efficacy...
April 4, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28374815/the-impact-of-a-prior-diagnosis-of-barrett-s-esophagus-on-esophageal-adenocarcinoma-survival
#17
Angela C Tramontano, Deirdre F Sheehan, Jennifer M Yeh, Chung Yin Kong, Emily C Dowling, Joel H Rubenstein, Julian A Abrams, John M Inadomi, Deborah Schrag, Chin Hur
OBJECTIVES: Endoscopic surveillance of patients with Barrett's Esophagus (BE) is recommended to detect esophageal adenocarcinoma (EAC) and its dysplasia precursors, but survival benefits are unclear. Using Surveillance, Epidemiology, and End Results (SEER) and linked Medicare data, we sought to determine the impact of a prior BE diagnosis on survival in patients with EAC. METHODS: Our analysis focused on patients over age 65 with primary EAC diagnosed in a SEER region from 2000-2011 and enrolled in Medicare...
April 4, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28370163/development-of-a-22q11ds-psycho-educational-programme-exploration-of-the-views-concerns-and-educational-needs-of-parents-caring-for-children-or-adolescents-with-22q11ds-in-relation-to-mental-health-issues
#18
T Alugo, H Malone, A Sheehan, I Coyne, A Lawlor, F McNicholas
BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is a multisystem genetic condition with a broad phenotype. It is associated with a high prevalence of depression and anxiety during childhood and increased risk of schizophrenia in adulthood. Despite this, studies report that families may receive inadequate information of mental health (MH) risks at diagnosis. Therefore, this study investigated parents' experiences of caring for a child with 22q11DS, investigated their knowledge regarding the risk of MH problems and assessed the need for a psycho-educational programme...
March 30, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28367055/multicenter-open-label-exploratory-clinical-trial-with-rhodiola-rosea-extract-in-patients-suffering-from-burnout-symptoms
#19
Siegfried Kasper, Angelika Dienel
PURPOSE: This study is the first clinical trial aiming to explore the clinical outcomes in burnout patients treated with Rhodiola rosea. The reported capacity of R. rosea to strengthen the organism against stress and its good tolerability offer a promising approach in the treatment of stress-related burnout. The aim of the treatment was to increase stress resistance, thus addressing the source rather than the symptoms of the syndrome and preventing subsequent diseases associated with a history of burnout...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28364701/restoring-function-in-major-depressive-disorder-a-systematic-review
#20
REVIEW
David V Sheehan, Kazuyuki Nakagome, Yuko Asami, Elizabeth A Pappadopulos, Matthieu Boucher
BACKGROUND: Functional impairment contributes to significant disability and economic burden in major depressive disorder (MDD). Treatment response is measured by improvement in depressive symptoms, but functional improvement often lags behind symptomatic improvement. Residual deficits are associated with relapse of depressive symptoms. METHODS: A literature search was conducted using the following terms: "major depressive disorder," "functional impairment," "functional outcomes," "recovery of function," "treatment outcome," "outcome assessment," "social functioning," "presenteeism," "absenteeism," "psychiatric status rating scales," and "quality of life...
February 24, 2017: Journal of Affective Disorders
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