Khaled Aboushaala, Ana V Chee, Sheila J Toro, Rajko Vucicevic, Catherine Yuh, Jake Dourdourekas, Ishani K Patel, Alejandro Espinoza-Orias, Chundo Oh, Lena Al-Harthi, Jaro Karppinen, Edward J Goldberg, Frank M Phillips, Matthew Colman, Frances M K Williams, Jeffrey A Borgia, Stefan Green, Christopher Forsyth, Howard S An, Dino Samartzis
PURPOSE: The following study aimed to determine the existence of blood biomarkers in symptomatic patients with or without lumbar Modic changes (MC). METHODS: A cross-sectional sub-analyses of a prospective cohort was performed. Fasting blood samples were collected from patients with and without lumbar MC who had undergone spinal fusion or microdiscectomy. An 80-plex panel and CCL5/RANTES were used to assess preoperative plasma cytokine concentrations. Patient demographics and imaging phenotypes were also assessed...
March 7, 2024: European Spine Journal