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macrophage migration inhibitory factor

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https://www.readbyqxmd.com/read/29227009/fetal-liver-injury-ameliorated-by-migration-inhibitory-factor-inhibition-in-a-rat-model-of-acute-pancreatitis-in-pregnancy
#1
Zheng-Da Guo, Liang Zhao, Peng Wang, Wen-Hong Deng, Qiao Shi, Teng Zuo, Yu-Pu Hong, Wei-Xing Wang
AIM: This study was designed to investigate and assess fetal liver injury in a rat model of acute pancreatitis in pregnancy (APIP) as well as its possible mechanisms and potential therapeutic targets. METHODS: The APIP model was induced by sodium taurocholate in Sprague-Dawley rats during the third trimester. ISO-1, a macrophage migration inhibitory factor (MIF) antagonist, was given before the induction of APIP. In addition, sham-operated rats at later gestation were set as controls...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29208960/mif-173-g%C3%A2-%C3%A2-c-rs755622-gene-polymorphism-modulates-tuberculosis-risk-evidence-from-a-meta-analysis-and-trial-sequential-analysis
#2
Mohammed Y Areeshi, Raju K Mandal, Sajad A Dar, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K Panda, B N Mishra, Naseem Akhter, Shafiul Haque
The macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in inhibiting the growth of pathogenic Mycobacterium tuberculosis (M.tb) and regulates immune responses against M.tb pathogen. MIF -173 G > C gene polymorphism may affect immunity in an individual and leads to susceptibility to tuberculosis (TB). A large number of studies have investigated the relevance of this polymorphism with TB risk, but their results were inconclusive. To obtain a precise conclusion, a meta-analysis was performed by retrieving six eligible studies from Google Scholar, PubMed (Medline), and EMBASE online databases...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29207187/macrophage-migration-inhibitory-factor-rescues-mesenchymal-stem-cells-from-doxorubicin-induced-senescence-though-the-pi3k-akt-signaling-pathway
#3
Wenzheng Xia, Meng Hou
Doxorubicin (DOXO), an anthracycline antibiotic, is a commonly used anticancer drug. Despite its widespread usage, the therapeutic effects of DOXO are limited by its cardiotoxicity. Mesenchymal stem cell (MSC)-based therapies have had positive outcomes in the treatment of DOXO-induced cardiac damage; however, DOXO exerts toxic effects on MSCs, decreasing the effectiveness of MSC therapy. Macrophage migration inhibitory factor (MIF) promotes MSC survival and rejuvenation, and thus is a promising candidate to protect MSCs against DOXO-induced injury...
November 23, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29207023/macrophage-migration-inhibitory-factor-promotes-warburg-effect-via-activation-of-the-nf%C3%A2-%C3%AE%C2%BAb-hif%C3%A2-1%C3%AE-pathway-in-lung-cancer
#4
Jun Li, Junhua Zhang, Fengjiao Xie, Jiangzhou Peng, Xu Wu
Macrophage migration inhibitory factor (MIF) is upregulated in various solid tumors, a process that is associated with tumor progression and metastasis. The present study aimed to investigate the role and the underlying mechanism of MIF in human lung cancer. Human lung cancer H358, H460, H524, H1650, H838, H1975 and A549 cell lines were used to examine the expression of MIF by real time‑quantitative polymerase chain reaction and western blotting. The lentivirus was used to overexpress MIF and the expression of MIF and hypoxia‑inducible factor 1‑α (HIF‑1α) were knocked down by shRNA or siRNA...
November 22, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29186613/biochemical-and-structural-characterization-of-a-novel-cooperative-binding-mode-by-pit-1-with-catt-repeats-in-the-macrophage-migration-inhibitory-factor-promoter
#5
Sorabh Agarwal, Thomas Yoonsang Cho
Overexpression of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) is linked to a number of autoimmune diseases and cancer. MIF production has been correlated to the number of CATT repeats in a microsatellite region upstream of the MIF gene. We have characterized the interaction of pituitary-specific positive transcription factor 1 (Pit-1) with a portion of the MIF promoter region flanking a microsatellite polymorphism (-794 CATT5-8). Using fluorescence anisotropy, we quantified tight complex formation between Pit-1 and an oligonucleotide consisting of eight consecutive CATT repeats (8xCATT) with an apparent Kd of 35 nM...
November 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29179278/-expression-of-macrophage-migration-inhibitory-factor-gene-in-placenta-tissue-and-its-correlation-with-gestational-diabetes-mellitus
#6
L Zheng, C Li, W H Qi, B L Qiao, H Zhao, Y B Zhou, C X Lu
Objective: To investigate the relationship between the expression of macrophage migration inhibitory factor (MIF) gene and the incidence of gestational diabetes mellitus (GDM) in Chinese Han population in northern China. Method: This study was consisted of 126 GDM women and 150 cases of healthy subjects who came from the obstetrics department of Maternity Hospital of Qingdao University and Maternity and Child Care Hospital of Donggang District of Rizhao. The protein expression of MIF in placenta tissue was detected by Western blot method...
November 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29120365/macrophage-migration-inhibitory-factor-predicts-outcome-in-complex-aortic-surgery
#7
Alexander Gombert, Christian Stoppe, Ann Christina Foldenauer, Tobias Schuerholz, Lukas Martin, Johannes Kalder, Gereon Schälte, Gernot Marx, Michael Jacobs, Jochen Grommes
The perioperative inflammatory response is associated with outcome after complex aortic repair. Macrophage migration inhibitory factor (MIF) shows protective effects in ischemia-reperfusion (IR), but also adverse pro-inflammatory effects in acute inflammation, potentially leading to adverse outcome, which should be investigated in this trial. This prospective study enrolled 52 patients, of whom 29 (55.7%) underwent open repair (OR) and 23 (44.3%) underwent endovascular repair (ER) between 2014 and 2015. MIF serum levels were measured until 72 h post-operatively...
November 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29113309/macrophage-migration-inhibitory-factor-promotes-vasculogenic-mimicry-formation-induced-by-hypoxia-via-cxcr4-akt-emt-pathway-in-human-glioblastoma-cells
#8
Xing Guo, Shugang Xu, Xiao Gao, Jian Wang, Hao Xue, Zihang Chen, Jinsen Zhang, Xiaofan Guo, Mingyu Qian, Wei Qiu, Gang Li
Macrophage migration inhibitory factor (MIF) is over-expressed and secreted in various cancer cells in particular in response to hypoxia. Recent studies have shown that, under hypoxic conditions, glioblastoma (GBM) cells display the ability to drive blood-perfused vasculogenic mimicry (VM). The aim of this study was to investigate the underlying mechanism of MIF in the regulation of hypoxia-induced VM in GBM cells. By analyzing clinical specimens, we observed the co-localization of MIF, C-X-C motif chemokine receptor 4 (CXCR4) and VM in hypoxic regions of gliomas...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107116/mitophagy-and-the-release-of-inflammatory-cytokines
#9
REVIEW
James Harris, Nadia Deen, Shahrzad Zamani, Md Abul Hasnat
Mitophagy is a selective form of autophagy in which damaged or dysfunctional mitochondria are specifically targeted by autophagosomes for lysosomal degradation. Studies have demonstrated that loss of autophagy/mitophagy can lead to a build-up of cytosolic reactive oxygen species and mitochondrial DNA, which can, in turn, activate immune signalling pathways that ultimately lead to the releases of inflammatory cytokines, including IL-1α, IL-1β, IL-18 and macrophage migration inhibitory factor (MIF). Moreover, release of these cytokines can subsequently promote the release of others, including IL-23 and IL-17...
October 26, 2017: Mitochondrion
https://www.readbyqxmd.com/read/29096759/circulating-macrophage-migration-inhibitory-factor-levels-and-its-polymorphisms-in-systemic-lupus-erythematosus-a-meta-analysis
#10
S-C Bae, Y H Lee
The present study aimed to systemically review the evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and systemic lupus erythematosus (SLE), as well as the associations between several polymorphisms in the MIF gene and SLE susceptibility. We performed a meta-analysis of serum/plasma levels of MIF in SLE patients and controls and evaluated evidence of associations between the MIF -173 C/G allele and -794CATT5-8 polymorphisms and the associated risk for SLE...
October 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29095944/mif-inhibition-interferes-with-the-inflammatory-and-t-cell-stimulatory-capacity-of-nod-macrophages-and-delays-autoimmune-diabetes-onset
#11
Hannelie Korf, Laura Breser, Jelter Van Hoeck, Janet Godoy, Dana P Cook, Benoit Stijlemans, Elien De Smidt, Carolien Moyson, João Paulo Monteiro Carvalho Mori Cunha, Virginia Rivero, Conny Gysemans, Chantal Mathieu
Macrophages contribute in the initiation and progression of insulitis during type 1 diabetes (T1D). However, the mechanisms governing their recruitment into the islets as well as the manner of retention and activation are incompletely understood. Here, we investigated a role for macrophage migration inhibitory factor (MIF) and its transmembrane receptor, CD74, in the progression of T1D. Our data indicated elevated MIF concentrations especially in long-standing T1D patients and mice. Additionally, NOD mice featured increased MIF gene expression and CD74+ leukocyte frequencies in the pancreas...
2017: PloS One
https://www.readbyqxmd.com/read/29080793/chemokines-and-cytokines-on-the-neuroimmunoaxis-inner-ear-neurotrophic-cytokines-in-development-and-disease-prospects-for-repair
#12
REVIEW
Kate F Barald, Yu-Chi Shen, Lynne M Bianchi
The earliest stages of neuronal and sensory cell development in vertebrate sensory organs depend on "inflammatory" immune system neurotrophic cytokines/chemokines. Although classical nerve growth factors, brain-derived neurotrophic factors and glial growth factors play critical roles at various stages, the earliest directive roles belong to immune system cytokines. In frogs, fishes, birds and mammals, macrophage migration inhibitory factor (MIF), monocyte chemoattractant protein 1 (MCP1) and RANTES, components of the "otocyst-derived factor", are involved in sorting, morphogenesis, providing directional neuronal outgrowth cues as well as survival factors for both neurons and sensory cells...
October 25, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29079416/macrophage-migration-inhibitory-factor-promotes-tumor-aggressiveness-of-esophageal-squamous-cell-carcinoma-via-activation-of-akt-and-inactivation-of-gsk3%C3%AE
#13
Rui-Min Liu, Dan-Ni Sun, Ye-Lin Jiao, Pan Wang, Juan Zhang, Ming Wang, Jin Ma, Man Sun, Bian-Li Gu, Pan Chen, Ke Liu, Heng Ma, She-Gan Gao, Yuan-Fang Ma, Yi-Jun Qi
The pleiotropic pro-inflammatory cytokine, macrophage migration inhibitory factor (MIF), represents an important link between chronic inflammation and tumorigenesis. Although accumulating evidence demonstrates that MIF overexpression is implicated in the development and progression of multiple cancers, including esophageal squamous cell carcinoma (ESCC), the molecular mechanisms underlying its tumor-promoting roles in ESCC remain unclear. In the present study, we observed that MIF is overexpressed in ESCC and correlated significantly with lymph node metastasis, advanced clinical stage, and poor survival of ESCC...
October 25, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29071813/serum-macrophage-migration-inhibitory-factor-as-a-biomarker-of-active-pulmonary-tuberculosis
#14
Zhong Bo Shang, Jun Wang, Shou Gang Kuai, Yin Yin Zhang, Qin Fang Ou, Hao Pei, Li Hua Huang
BACKGROUND: Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine with chemokine-like functions, has been shown to play a central role in several acute and chronic inflammatory diseases. However, limited information is available regarding the use of MIF as an inflammatory pathway marker in patients with tuberculosis. This study aimed to investigate the association of MIF with IFN-γ and TNF-α in active pulmonary tuberculosis (APTB) following anti-tuberculosis treatment...
January 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29067254/temporal-trend-of-autonomic-nerve-function-and-hsp27-mif-and-pai-1-in-type-1-diabetes
#15
Malin Zimmerman, Sara Rolandsson Enes, Hanna Skärstrand, Kaveh Pourhamidi, Anders Gottsäter, Per Wollmer, Olov Rolandsson, Gunilla Westergren-Thorsson, Lars B Dahlin
AIM: Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. This study focuses on Heat Shock Protein 27 (HSP27), Macrophage Migration Inhibitory Factor (MIF), Plasminogen Activator Inhibitor-1 (PAI-1) and HbA1c and their possible roles in effects of diabetes on the autonomic nervous system. METHODS: Patients with T1D (n = 32, 41% women) were recruited in 1985 and followed up on four occasions (1989, 1993, 1998, and 2005)...
June 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29066595/physiological-effects-of-high-altitude-trekking-on-gonadal-thyroid-hormones-and-macrophage-migration-inhibitory-factor-mif-responses-in-young-lowlander-women
#16
Vittore Verratti, Francesca Ietta, Luana Paulesu, Roberta Romagnoli, Ilaria Ceccarelli, Christian Doria, Giorgio Fanò Illic, Camillo Di Giulio, Anna M Aloisi
Altitude hypoxia is often associated with impairment of human reproduction. In this study, hormones and macrophage migration inhibitory factor (MIF, a proinflammatory cytokine with key roles in human reproduction) were determined in seven regularly menstruating, lowlander native women living at sea level participating in 14 days of trekking at moderate and high altitude. Blood and saliva samples were collected from each subject at high altitude (5050 m a.s.l. [above sea level]), and at sea level before and after the expedition...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29059216/protective-effect-of-dexamethasone-on-5-fu-induced-oral-mucositis-in-hamsters
#17
Susana Barbosa Ribeiro, Aurigena Antunes de Araújo, Raimundo Fernandes de Araújo Júnior, Gerly Anne de Castro Brito, Renata Carvalho Leitão, Maisie Mitchele Barbosa, Vinicius Barreto Garcia, Aldo Cunha Medeiros, Caroline Addison Carvalho Xavier de Medeiros
Oral mucositis (OM) is an important side effect of cancer treatment, characterized by ulcerative lesions in the mucosa of patients undergoing radiotherapy or chemotherapy, which has marked effects on patient quality of life and cancer therapy continuity. Considering that few protocols have demonstrated efficacy in preventing this side effect, the aim of this study was to examine the effect of dexamethasone (DEX) on OM induced by 5-fluorouracil (5-FU) in hamsters by studying signaling pathways. OM was induced in hamsters by 5-FU followed by mechanical trauma (MT) on day 4...
2017: PloS One
https://www.readbyqxmd.com/read/29027966/myocardial-expression-of-macrophage-migration-inhibitory-factor-in-patients-with-heart-failure
#18
Julia Pohl, Ulrike B Hendgen-Cotta, Pia Stock, Peter Luedike, Hideo Andreas Baba, Markus Kamler, Tienush Rassaf
Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory protein and contributes to several different inflammatory and ischemic/hypoxic diseases. MIF was shown to be cardioprotective in experimental myocardial ischemia/reperfusion injury and its expression is regulated by the transcription factor hypoxia-inducible factor (HIF)-1α. We here report on MIF expression in the failing human heart and assess myocardial MIF in different types of cardiomyopathy. Myocardial tissue samples from n = 30 patients were analyzed by quantitative Real-Time PCR...
October 13, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28993199/unraveling-the-role-of-hypoxia-inducible-factor-hif-1%C3%AE-and-hif-2%C3%AE-in-the-adaption-process-of-human-microvascular-endothelial-cells-hmec-1-to-hypoxia-redundant-hif-dependent-regulation-of-macrophage-migration-inhibitory-factor
#19
Martin Hahne, Peggy Schumann, Mathias Mursell, Cindy Strehl, Paula Hoff, Frank Buttgereit, Timo Gaber
Hypoxia driven angiogenesis is a prominent feature of tissue regeneration, inflammation and tumor growth and is regulated by hypoxia-inducible factor (HIF)-1 and -2. The distinct functions of HIFs in the hypoxia-induced angiogenesis and metabolic switch of endothelial cells are still unknown and therefore aim of this study. We investigated the role of HIF-1 and -2 in the adaptation of immortalized human microvascular endothelial cells (HMEC-1) to hypoxic conditions (1% O2) in terms of angiogenesis, cytokine secretion, gene expression and ATP/ADP-ratio using shRNA-mediated reduction of the oxygen sensitive α-subunits of either HIF-1 or HIF-2 or the combination of both...
October 6, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28990052/macrophage-migration-inhibitory-factor-knockdown-inhibit-viability-and-induce-apoptosis-of-pvm-ms
#20
Wenjing Zhang, Jian Zheng, Juan Meng, Lingling Neng, Xiaohua Chen, Zhaobing Qin
Previous studies have suggested that macrophage migration inhibitory factor (MIF) serves an important role in hearing function; however, the underlying mechanism remains unclear. In the present study, perivascular‑resident macrophage‑like melanocytes (PVM/Ms) from the stria vascularis of the lateral cochlear wall in young and aged mice were isolated. The mRNA and protein expression levels of MIF were determined using reverse transcription‑quantitative polymerase chain reaction analysis, and western blotting, respectively...
December 2017: Molecular Medicine Reports
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