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macrophage migration inhibitory factor

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https://www.readbyqxmd.com/read/29447014/macrophage-migration-inhibitory-factor-mif-inhibitor-z-590-suppresses-cartilage-destruction-in-adjuvant-induced-arthritis-via-inhibition-of-macrophage-inflammatory-activation
#1
Zhiyu Zhang, Rong Zhang, Linlang Li, Lijun Zhu, Shiyuan Gao, Qiran Lu, Yihui Gu, Yu Zhang, Huicui Yang, Tingjun Hou, Xuechu Zhen, Long Tai Zheng
INTRODUCTION: Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory mediator that is involved in the progression of rheumatoid arthritis (RA). Previously, we demonstrated a small molecule compound 3-[(biphenyl-4-ylcarbonyl) carbamothioyl] amino benzoic acid (Z-590) could inhibit MIF activity with docking-based virtual screening and experimental evaluation. MATERIALS AND METHODS: The LPS activated RAW264.7 macrophage cells were used to determine the anti-inflammatory effects of Z-590 in vitro...
February 15, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29445150/loss-of-ndrg2-in-liver-microenvironment-inhibits-cancer-liver-metastasis-by-regulating-tumor-associate-macrophages-polarization
#2
Mengyang Li, Xiaofeng Lai, Ying Zhao, Yuan Zhang, Minghui Li, Danxiu Li, Jing Kong, Yong Zhang, Pengyu Jing, Huichen Li, Hongyan Qin, Liangliang Shen, Libo Yao, Jipeng Li, Kefeng Dou, Jian Zhang
The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in the liver play crucial roles in the metastasis process. Shifting tumor-promoting M2-like TAMs toward the M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and the secretion of inhibitory factors, may be a potential therapeutic strategy for liver cancer metastasis treatment.We first cloned NDRG2 (N-myc downstream-regulated gene 2) and verified its tumor suppressor role in multiple solid tumors, including colorectal cancer and hepatocellular carcinoma...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29440696/the-fate-of-a-hapten-from-the-skin-to-modification-of-macrophage-migration-inhibitory-factor-mif-in-lymph-nodes
#3
Isabella Karlsson, Kristin Samuelsson, Carl Simonsson, Anna-Lena Stenfeldt, Ulrika Nilsson, Leopold L Ilag, Charlotte Jonsson, Ann-Therese Karlberg
Skin (contact) allergy, the most prevalent form of immunotoxicity in humans, is caused by low molecular weight chemicals (haptens) that penetrate stratum corneum and modify endogenous proteins. The fate of haptens after cutaneous absorption, especially what protein(s) they react with, is largely unknown. In this study the fluorescent hapten tetramethylrhodamine isothiocyanate (TRITC) was used to identify hapten-protein conjugates in the local lymph nodes after topical application, as they play a key role in activation of the adaptive immune system...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29434819/tangshen-formula-improves-inflammation-in-renal-tissue-of-diabetic-nephropathy-through-sirt1-nf-%C3%AE%C2%BAb-pathway
#4
Yue-Guang Du, Ke-Na Zhang, Zong-Lei Gao, Fengjiao Dai, Xi-Xi Wu, Ke-Fu Chai
The present study investigated the mechanism underlying the anti-inflammatory effects of Tangshen formula (TS) in Sprague Dawley (SD) rats with diabetic nephropathy (DN). A rat model of DN was established by intraperitoneal injection of 1% (40 mg/kg) streptozotocin and administration of a high fat and glucose diet. Subsequently, SD rats were randomly divided into six groups (n=8): A DN group, a valsartan group, a high-dose TS group, a middle-dose TS group, a low-dose TS group and a control group with normal SD rats...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29428527/discovery-of-chromenes-as-inhibitors-of-macrophage-migration-inhibitory-factor
#5
Tjie Kok, Hannah Wapenaar, Kan Wang, Constantinos G Neochoritis, Tryfon Zarganes-Tzitzikas, Giordano Proietti, Nikolaos Eleftheriadis, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Robbert H Cool, Gerrit J Poelarends, Alexander Dömling, Frank J Dekker
Macrophage migration inhibitory factor (MIF) is an essential signaling cytokine with a key role in the immune system. Binding of MIF to its molecular targets such as, among others, the cluster of differentiation 74 (CD74) receptor plays a key role in inflammatory diseases and cancer. Therefore, the identification of MIF binding compounds gained importance in drug discovery. In this study, we aimed to discover novel MIF binding compounds by screening of a focused compound collection for inhibition of its tautomerase enzyme activity...
December 24, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29427535/endogenous-biological-factors-modulated-by-substrate-stiffness-regulate-endothelial-differentiation-of-mesenchymal-stem-cells
#6
Yong-Chao Jiang, Hong-Li Jiao, Ming-Song Lee, To Wang, Lih-Sheng Turng, Qian Li, Wan-Ju Li
During the process of tissue regeneration facilitated by stem cells, physical properties of a scaffold affect behavior and activities of the cell. To enhance differentiation of human mesenchymal stem cells (MSCs) into endothelial-like cells (ELCs), we used electrospun fibrous substrates with different stiffness to enhance the differentiation. A simple method of annealing with different lengths of treatment time was employed to modulate stiffness of electrospun fibrous substrates without changing their chemistry...
February 10, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29412660/role-of-the-cysteine-81-residue-of-macrophage-migration-inhibitory-factor-as-a-molecular-redox-switch
#7
Alexander Schinagl, Randolf J Kerschbaumer, Nicolas Sabarth, Patrice Douillard, Peter Scholz, Dirk Voelkel, Julia C Hollerweger, Peter Goettig, Hans Brandstetter, Friedrich Scheiflinger, Michael Thiele
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory and tumor-promoting cytokine that occurs in two redox-dependent immunologically distinct conformational isoforms. The disease-related structural isoform of MIF (oxMIF) can be specifically and predominantly detected in the circulation of patients with inflammatory diseases and in tumor tissue, whereas the ubiquitously expressed isoform of MIF (redMIF) is abundantly expressed in healthy and diseased subjects. In this article, we report that cysteine 81 within MIF serves as a "switch cysteine" for the conversion of redMIF to oxMIF...
February 15, 2018: Biochemistry
https://www.readbyqxmd.com/read/29408092/topical-application-of-hydroxysafflor-yellow-a-accelerates-the-wound-healing-in-streptozotocin-induced-t1dm-rats
#8
Si-Qian Gao, Chen Chang, Xiao-Qian Niu, Long-Jian Li, Yan Zhang, Jian-Qing Gao
To investigate the effects of Hydroxysafflor Yellow A (HSYA), which is derived from safflower, on the proliferation, migration and angiogenesis of cells in vitro and its potential efficacy in vivo when topically applied to a diabetic wound. Human umbilical vein endothelial cells (HUVECs) and mouse macrophage cells (RAW264.7) were used to evaluate angiogenesis and anti-inflammatory activities, respectively. The influence of HSYA on the wound scratch assay was investigated in keratinocytes. A splinted excisional wound model in rats with TIDM induced by streptozotocin was used to assess the effects of wound healing...
January 31, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29404888/hiv-1-nef-cawleaq-motif-a-regulator-of-monocytes-invasion-through-eno1-modulation
#9
Reshu Saxena, Umesh Kumar Vekariya, Pradeep Kumar, Amit Kumar Tripathi, Jimut Kanti Ghosh, Raj Kamal Tripathi
HIV-1 transmission and spread involves significant host-virus interaction. Possible targets for obstacle of HIV-1 lie at the site of mucosal barriers. Thus a better understanding of how HIV-1 infects target cells at such sites and leads their invasion is required, with prime focus on the host determinants regulating HIV-1 spread. For the viral infectivity and pathogenicity, HIV-1 Nef facilitates immune evasion through protein-protein interactions within host cell. HIV-1 Nef is significant for viral infectivity and pathogenicity...
February 5, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29403061/laminar-flow-attenuates-macrophage-migration-inhibitory-factor-expression-in-endothelial-cells
#10
Congzhen Qiao, Shengdi Li, Haocheng Lu, Fan Meng, Yanbo Fan, Yanhong Guo, Y Eugene Chen, Jifeng Zhang
Macrophage migration inhibitory factor (MIF) is a non-canonical cytokine that is involved in multiple inflammatory diseases, including atherosclerosis. High MIF expression found in leukocytes which facilitates the initiation and progression of atherosclerosis. However, little is known about biomechanical forces in the induction of MIF in endothelial cells (ECs). Here, we show that laminar shear stress (LS) inhibits the expression of MIF in ECs. By profiling the whole transcriptome of human coronary artery ECs under different shear stress, we found that athero-protective LS attenuates the expression of MIF whereas pro-atherosclerotic oscillatory shear stress (OS) significantly increased the expression of MIF...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29401625/novel-half-life-extended-anti-mif-nanobodies-protect-against-endotoxic-shock
#11
Amanda Sparkes, Patrick De Baetselier, Lea Brys, Inês Cabrito, Yann G-J Sterckx, Steve Schoonooghe, Serge Muyldermans, Geert Raes, Richard Bucala, Peter Vanlandschoot, Jo A Van Ginderachter, Benoît Stijlemans
Sepsis-leading to septic shock-is the leading cause of death in intensive care units. The systemic inflammatory response to infection, which is initiated by activated myeloid cells, plays a key role in the lethal outcome. Macrophage migration inhibitory factor (MIF) is an upstream immunoregulatory mediator, released by myeloid cells, that underlies a common genetic susceptibility to different infections and septic shock. Accordingly, strategies that are aimed at inhibiting the action of MIF have therapeutic potential...
January 25, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29397904/mif-promotes-a-differential-th1-th2-th17-inflammatory-response-in-human-primary-cell-cultures-predominance-of-th17-cytokine-profile-in-pbmc-from-healthy-subjects-and-increase-of-il-6-and-tnf-%C3%AE-in-pbmc-from-active-sle-patients
#12
Ulises De la Cruz-Mosso, Trinidad García-Iglesias, Richard Bucala, Iris Estrada-García, Laura González-López, Sergio Cerpa-Cruz, Isela Parra-Rojas, Jorge Iván Gámez-Nava, Edsaúl Emilio Pérez-Guerrero, José Francisco Muñoz-Valle
Macrophage migration Inhibitory Factor (MIF) is a cytokine associated with the pathogenesis of autoimmune inflammatory diseases. There is evidence that MIF functions in a positive-feedback-loop with proinflammatory cytokines and could perpetuate the inflammatory process in Systemic Lupus Erythematosus (SLE).The aim of this study was to assess the effect of recombinant-human-MIF (rhMIF) on the expression of Th1, Th2 and Th17 cytokines in Peripheral Blood Mononuclear Cells (PBMC) from Healthy Subjects (HS) and SLE patients...
December 26, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29385715/different-achilles-tendon-pathologies-show-distinct-histological-and-molecular-characteristics
#13
Franka Klatte-Schulz, Susann Minkwitz, Aysha Schmock, Nicole Bormann, Alper Kurtoglu, Serafeim Tsitsilonis, Sebastian Manegold, Britt Wildemann
Reasons for the development of chronic tendon pathologies are still under debate and more basic knowledge is needed about the different diseases. The aim of the present study was therefore to characterize different acute and chronic Achilles tendon disorders. Achilles tendon samples from patients with chronic tendinopathy (n = 7), chronic ruptures (n = 6), acute ruptures (n = 13), and intact tendons (n = 4) were analyzed. The histological score investigating pathological changes was significantly increased in tendinopathy and chronic ruptures compared to acute ruptures...
January 30, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29373661/macrophage-migration-inhibitory-factor-and-microrna-451a-in-response-to-mindfulness-based-therapy-or-treatment-as-usual-in-patients-with-depression-anxiety-or-stress-and-adjustment-disorders
#14
Xiao Wang, Kristina Sundquist, Karolina Palmér, Anna Hedelius, Ashfaque Memon, Jan Sundquist
Background: Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that has been associated with various psychiatric disorders. MicroRNA-451a (miR-451a) can directly target MIF and down-regulate its expression in cells. However, the role of MIF and miR-451a in psychiatric patients treated with psychotherapeutic interventions is unknown. In this study, our aim was to investigate levels of MIF and its regulating miR-451a in patients with depression, anxiety or stress- and adjustment disorders who underwent mindfulness-based therapy or treatment as usual (TAU)...
January 24, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29371697/rnf138-mediated-ubiquitination-of-rps3-is-required-for-resistance-of-glioblastoma-cells-to-radiation-induced-apoptosis
#15
Wanyeon Kim, HyeSook Youn, Sungmin Lee, EunGi Kim, Daehoon Kim, Jung Sub Lee, Jae-Myung Lee, BuHyun Youn
An interaction between ribosomal protein S3 (rpS3) and nuclear factor kappa B or macrophage migration inhibitory factor in non-small-cell lung cancer is responsible for radioresistance. However, the role of rpS3 in glioblastoma (GBM) has not been investigated to date. Here we found that in irradiated GBM cells, rpS3 translocated into the nucleus and was subsequently ubiquitinated by ring finger protein 138 (RNF138). Ubiquitin-dependent degradation of rpS3 consequently led to radioresistance in GBM cells. To elucidate the apoptotic role of rpS3, we analyzed the interactome of rpS3 in ΔRNF138 GBM cells...
January 26, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29371591/mif-inhibits-the-formation-and-toxicity-of-misfolded-sod1-amyloid-aggregates-implications-for-familial-als
#16
Neta Shvil, Victor Banerjee, Guy Zoltsman, Tom Shani, Joy Kahn, Salah Abu-Hamad, Niv Papo, Stanislav Engel, Jurgen Bernhagen, Adrian Israelson
Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease caused by the progressive loss of motor neurons in the brain and spinal cord. It has been suggested that toxicity of mutant SOD1 results from its misfolding, however, it is yet unclear why misfolded SOD1 accumulates specifically within motor neurons. We recently demonstrated that macrophage migration inhibitory factor (MIF)-a multifunctional protein with cytokine/chemokine activity and cytosolic chaperone-like properties-inhibits the accumulation of misfolded SOD1...
January 25, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29358859/astragaloside-iv-inhibits-pathological-functions-of-gastric-cancer-associated-fibroblasts
#17
Zhen-Fei Wang, Da-Guang Ma, Zhe Zhu, Yong-Ping Mu, Yong-Yan Yang, Li Feng, Hao Yang, Jun-Qing Liang, Yong-Yan Liu, Li Liu, Hai-Wen Lu
AIM: To investigate the inhibitory effect of astragaloside IV on the pathological functions of cancer-associated fibroblasts, and to explore the underlying mechanism. METHODS: Paired gastric normal fibroblast (GNF) and gastric cancer-associated fibroblast (GCAF) cultures were established from resected tissues. GCAFs were treated with vehicle control or different concentrations of astragaloside IV. Conditioned media were prepared from GNFs, GCAFs, control-treated GCAFs, and astragaloside IV-treated GCAFs, and used to culture BGC-823 human gastric cancer cells...
December 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29357418/endogenous-h2s-sensitizes-the-par4-induced-bladder-pain
#18
Wenfu Wang, Qiyu Bo, Jian Du, Xin Yu, Kejia Zhu, Jianfeng Cui, Hongda Zhao, Yong Wang, Benkang Shi, Yaofeng Zhu
Bladder pain is a prominent symptom of interstitial cystitis / painful bladder syndrome (IC/PBS). Hydrogen sulfide (H2S) generated by cystathionine β-synthase (CBS) or cystathionine γ-lyase (CSE) facilitates bladder hypersensitivity. We assessed involvement of the H2S pathway in PAR4 (protease-activated receptor 4)-induced bladder pain. A bladder pain model was induced by intravesical instillation of PAR4-activating peptide into mice. The role of H2S in this model was evaluated by i.p. pre-administration of D,L-propargylglycine (PAG), aminooxyacetic acid (AOAA) or S-adenosylmethionine (SAM), or the pre-intravesical administration of NaHS...
January 10, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29350381/macrophage-migration-inhibitory-factor-knockout-attenuates-endotoxin-induced-cardiac-dysfunction-in-mice
#19
Jie Zhang, Xin Zhang, Yuqi Cui, Lianqun Cui, Peng Zhao
BACKGROUND: The accumulated evidence suggests that macrophage migration inhibitory factor (MIF) plays a key role not only in acute and chronic inflammatory diseases but also in cardiovascular disease. The cardiac dysfunction is related to lipopolysaccharide (LPS) in sepsis. AIM: This study was designed to examine whether MIF mediates LPS-induced cardiac dysfunction and address the mechanisms. METHODS: Echocardiography, immunohistochemical analysis, cell shortening/relengthening and intracellular Ca2+ fluorescence evaluation were performed in whole hearts and isolated cardiomyocytes from C57 and MIF knockout mice treated with or without LPS...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29331700/effects-of-macrophage-migration-inhibitory-factor-on-cardiac-reperfusion-injury-in-mice-with-depression-induced-by-constant-darkness
#20
Lu-Yuan Tao, Ming-Yuan Huang, Saroj-Thapa, Jiao-Ni Wang, Shao-Ze Wu, Fei He, Kai-Yu Huang, Yang-Jing Xue, Lingwei-Jin, Lian-Ming Liao, Ji-Fei Tang, Kang-Ting Ji
RATIONALE: Depression is associated with coronary artery disease and increases adverse outcomes and mortality in patients with acute myocardial infarction, but the underlying pathophysiological mechanisms remain unclear. OBJECTIVE: To evaluate the effect of macrophage migration inhibitory factor (MIF) on cardiac ischemia-reperfusion (I/R) injury in mice with constant darkness-induced depression. METHODS AND RESULTS: Twenty C57BL/6 mice (8 weeks old, male) were randomly divided into 2 groups: one group was housed in a 12h light/dark cycle environment (LD) and the other in a constant darkness environment (DD)...
December 27, 2017: Journal of Affective Disorders
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