keyword
MENU ▼
Read by QxMD icon Read
search

macrophage migration inhibitory factor

keyword
https://www.readbyqxmd.com/read/27920521/celastrol-nanomicelles-attenuate-cytokine-secretion-in-macrophages-and-inhibit-macrophage-induced-corneal-neovascularization-in-rats
#1
Zhanrong Li, Jingguo Li, Lei Zhu, Ying Zhang, Junjie Zhang, Lin Yao, Dan Liang, Liya Wang
The aim of the present study was to investigate the inhibitory effects of celastrol-loaded nanomicelles (CNMs) on activated macrophage-induced corneal neovascularization (CNV) in rats and cytokine secretion in macrophages. Using an angiogenesis assay in vitro, we detected the effects of CNMs on human umbilical vein endothelial cell (HUVEC) migration and invasion. In addition, the expression levels of cytokines secreted from hypoxia-induced macrophages were assessed through cytokine array analysis. The expression of hypoxia-inducible factors-1α (HIF-1α), nuclear factor-kappa B p65 (NF-κB p65), phospho-nuclear factor-kappa B p65 (phospho-NF-κB p65), p38 mitogen-activated protein kinase (p38 MAPK), phospho-p38 MAPK, extracellular signal-regulated kinase 1/2 (ERK1/2), and phospho-ERK1/2 was analyzed by western blotting...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27919728/voluntary-running-improves-depressive-behaviours-and-the-structure-of-the-hippocampus-in-rats-a-possible-impact-of-myokines
#2
Magda A Eldomiaty, Shaima M Almasry, Maha K Desouky, Sami A Algaidi
This study investigated the impact of voluntary exercise on depressive behaviours, serum and hippocampal levels of myokines, and histopathological features of hippocampal formation in rats. Depressed rats were allowed to voluntarily run on a wheel for 3 weeks. Locomotor activity was assessed by a forced swimming test and the myokine levels in sera and hippocampal homogenates were measured using Enzyme-linked Immunosorbent Assay. Brain sections were analysed for hippocampal structure and neuronal counts. Voluntary running produced significant increase in the distance moved by rats and significant decrease in immobility duration...
December 2, 2016: Brain Research
https://www.readbyqxmd.com/read/27884769/upregulation-of-cd74-and-its-potential-association-with-disease-severity-in-subjects-with-ischemic-stroke
#3
Liu Yang, Ying Kong, Honglei Ren, Minshu Li, Chang-Juan Wei, Elaine Shi, Wei-Na Jin, Junwei Hao, Arthur A Vandenbark, Halina Offner
Macrophage migration inhibitory factor (MIF) is a key cytokine/chemokine in the activation and recruitment of inflammatory T lymphocytes known to exacerbate experimental stroke severity. MIF effects are mediated through its primary cellular receptor, CD74, the MHC class II invariant chain present on all class II expressing cells, including monocytes, macrophages and dendritic cells (DC). We demonstrated previously that partial MHC class II/peptide constructs (pMHC) can effectively treat mice with experimental stroke, in part through their ability to competitively inhibit MIF/CD74 interactions and downstream signaling...
November 21, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27872288/mif-allele-dependent-regulation-of-the-mif-coreceptor-cd44-and-role-in-rheumatoid-arthritis
#4
Seung-Ah Yoo, Lin Leng, Bum-Joon Kim, Xin Du, Pathricia V Tilstam, Kyung Hee Kim, Jin-Sun Kong, Hyung-Ju Yoon, Aihua Liu, Tian Wang, Yan Song, Maor Sauler, Jurgen Bernhagen, Christopher T Ritchlin, Patty Lee, Chul-Soo Cho, Wan-Uk Kim, Richard Bucala
Fibroblast-like synoviocytes mediate joint destruction in rheumatoid arthritis and exhibit sustained proinflammatory and invasive properties. CD44 is a polymorphic transmembrane protein with defined roles in matrix interaction and tumor invasion that is also a signaling coreceptor for macrophage migration inhibitory factor (MIF), which engages cell surface CD74. High-expression MIF alleles (rs5844572) are associated with rheumatoid joint erosion, but whether MIF signaling through the CD74/CD44 receptor complex promotes upstream autoimmune responses or contributes directly to synovial joint destruction is unknown...
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27872094/mif-induced-stromal-pkc%C3%AE-il8-is-essential-in-human-acute-myeloid-leukemia
#5
Amina Abdul-Aziz, Manar Shafat, Tarang Mehta, Federica Di Palma, Matthew Lawes, Stuart A Rushworth, Kristian Bowles
Acute myeloid leukemia (AML) cells exhibit a high level of spontaneous apoptosis when cultured in vitro but have a prolonged survival time in vivo, indicating that tissue microenvironment plays a critical role in promoting AML cell survival. In vitro studies have shown that bone marrow-mesenchymal stromal cells (BM-MSC) protect AML blasts from spontaneous and chemotherapy-induced apoptosis. Here we report a novel interaction between AML blasts and BM-MSC which benefits AML proliferation and survival. We initially examined the cytokine profile in cultured human AML compared to AML cultured with BM-MSC and found that macrophage-migration inhibitory factor (MIF) was highly expressed by primary AML, and that interleukin-8 (IL-8) was increased in AML/BM-MSC co-cultures...
November 21, 2016: Cancer Research
https://www.readbyqxmd.com/read/27852364/-the-expression-of-macrophage-migration-inhibitory-factor-in-obstructive-sleep-apnea-hypopnea-syndrome-and-its-injury-to-endothelial-cells
#6
P Yuan, W J Wang, D F Li, Q Ou, X L Gao
Objective: To study the expression of macrophage migration inhibitory factor (MIF) in obstructive sleep apnea hypopnea syndrome (OSAHS) and its injury to endothelial cells. Methods: According to the PSG test results, subjects who were the first time to take PSG examination without treatment (n=71) were divided into a control group (n=20), a mild OSAHS group (n=19), a moderate OSAHS group (n=15) and severe OSAHS group (n=17). For each patients, 4 ml fasting peripheral blood was obtained when PSG was finished around 6: 30 in the next morning, and the MIF level in plasma was detected with the ELISA method...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27846469/a-nuclease-that-mediates-cell-death-induced-by-dna-damage-and-poly-adp-ribose-polymerase-1
#7
Yingfei Wang, Ran An, George K Umanah, Hyejin Park, Kalyani Nambiar, Stephen M Eacker, BongWoo Kim, Lei Bao, Maged M Harraz, Calvin Chang, Rong Chen, Jennifer E Wang, Tae-In Kam, Jun Seop Jeong, Zhi Xie, Stewart Neifert, Jiang Qian, Shaida A Andrabi, Seth Blackshaw, Heng Zhu, Hongjun Song, Guo-Li Ming, Valina L Dawson, Ted M Dawson
Inhibition or genetic deletion of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) is protective against toxic insults in many organ systems. The molecular mechanisms underlying PARP-1-dependent cell death involve release of mitochondrial apoptosis-inducing factor (AIF) and its translocation to the nucleus, which results in chromatinolysis. We identified macrophage migration inhibitory factor (MIF) as a PARP-1-dependent AIF-associated nuclease (PAAN). AIF was required for recruitment of MIF to the nucleus, where MIF cleaves genomic DNA into large fragments...
October 7, 2016: Science
https://www.readbyqxmd.com/read/27844180/association-of-genetic-polymorphisms-in-mif-with-breast-cancer-risk-in-chinese-women
#8
Shuai Lin, Meng Wang, Xinghan Liu, Wenge Zhu, Yan Guo, Zhiming Dai, Pengtao Yang, Tian Tian, Cong Dai, Yi Zheng, Chunyan Hu, Linyan Wei, Zhijun Dai
Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene variants (rs755622, rs1803976, rs11548059) with BC susceptibility in Chinese women. Total 560 breast cancer patients and 583 age- and sex-matched healthy individuals were recruited from Northwest China, and the DNA was genotyped by Sequenom MassARRAY...
November 14, 2016: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/27833444/association-of-macrophage-migration-inhibitory-factor-promoter-polymorphism-173g-c-with-susceptibility-to-childhood-asthma
#9
Tarek Z El-Adly, Sally Kamal, Hala Selim, Shahira Botros
INTRODUCTION: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays an important role in the pathogenesis of asthma. Polymorphisms associated with inflammatory diseases exist in the promoter region of MIF, which alter its expression. We aimed to study the association of MIF promoter polymorphism -173G/C with childhood asthma. MATERIAL AND METHODS: In this case-control study, we recruited 60 pediatric patients with bronchial asthma and 90 age- and sex-matched healthy controls...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27825106/macrophage-migration-inhibitory-factor-protects-from-nonmelanoma-epidermal-tumors-by-regulating-the-number-of-antigen-presenting-cells-in-skin
#10
Tania Brocks, Oleg Fedorchenko, Nicola Schliermann, Astrid Stein, Ute M Moll, Seth Seegobin, Manfred Dewor, Michael Hallek, Yvonne Marquardt, Katharina Fietkau, Ruth Heise, Sebastian Huth, Herbert Pfister, Juergen Bernhagen, Richard Bucala, Jens M Baron, Guenter Fingerle-Rowson
The response of the skin to harmful environmental agents is shaped decisively by the status of the immune system. Keratinocytes constitutively express and secrete the chemokine-like mediator, macrophage migration inhibitory factor (MIF), more strongly than dermal fibroblasts, thereby creating a MIF gradient in skin. By using global and epidermis-restricted Mif knockout mice (Mif(-/-) and K14-Cre(+/tg); Mif(fl/fl)), we found that MIF both recruits and maintains antigen-presenting cells in the dermis/epidermis...
October 19, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27811451/expressions-of-macrophage-migration-inhibitory-factor-in-patients-with-chronic-kidney-disease
#11
Y Liu, X Zhang, G Liu, J Huang, Y Pan, Z Hu
CONTEXT: Uremic cardiomyopathy is a risk factor of end-stage renal disease (ESRD) and is responsible for high mortality rates and increased left ventricular mass index (LVMI). Macrophage migration inhibitory factor (MIF) promotes inflammation and is an important factor in uremic cardiomyopathy. AIMS: The aim of this study is to investigate the effects of serum macrophage MIF on myocardial hypertrophy in ESRD patients and to examine the relation of this factor to clinical characteristics...
November 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27806135/a-trematode-parasite-derived-growth-factor-binds-and-exerts-influences-on-host-immune-functions-via-host-cytokine-receptor-complexes
#12
Azad A Sulaiman, Katarzyna Zolnierczyk, Ornampai Japa, Jonathan P Owen, Ben C Maddison, Richard D Emes, Jane E Hodgkinson, Kevin C Gough, Robin J Flynn
The trematode Fasciola hepatica is responsible for chronic zoonotic infection globally. Despite causing a potent T-helper 2 response, it is believed that potent immunomodulation is responsible for rendering this host reactive non-protective host response thereby allowing the parasite to remain long-lived. We have previously identified a growth factor, FhTLM, belonging to the TGF superfamily can have developmental effects on the parasite. Herein we demonstrate that FhTLM can exert influence over host immune functions in a host receptor specific fashion...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27796618/distinct-secretory-activity-and-clinical-impact-of-subcutaneous-abdominal-adipose-tissue-in-women-with-rheumatoid-arthritis-and-osteoarthritis
#13
Ewa Kontny, Agnieszka Zielińska, Urszula Skalska, Krystyna Księżopolska-Orłowska, Piotr Głuszko, Włodzimierz Maśliński
In the general population, low-grade inflammation of adipose tissue accompanies obesity and contributes to cardiovascular disease (CVD) development, but the implication of this tissue in rheumatic disease pathology is unclear. Therefore, we characterized the secretory activity of subcutaneous abdominal adipose tissue (SAAT) of females with rheumatoid arthritis (RA) and osteoarthritis (OA) and searched for its relationship with intensity of systemic inflammation, body composition and comorbidity. The secretion of classical adipokines (leptin, adiponectin), pro- and anti-inflammatory factors, i...
October 28, 2016: Inflammation
https://www.readbyqxmd.com/read/27793992/identification-of-iguratimod-as-an-inhibitor-of-macrophage-migration-inhibitory-factor-mif-with-steroid-sparing-potential
#14
Joshua Bloom, Christine Metz, Saisha Nalawade, Julian Casabar, Kai Fan Cheng, Mingzhu He, Barbara Sherry, Thomas Coleman, Thomas Forsthuber, Yousef Al-Abed
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in a broad range of inflammatory and oncologic diseases. MIF is unique among cytokines in terms of its release profile and inflammatory role, notably as an endogenous counter- regulator of the anti-inflammatory effects of glucocorticoids. In addition, it exhibits a catalytic tautomerase activity amenable to the design of high-affinity small molecule inhibitors. Although several classes of these compounds have been identified, biological characterization of these molecules remains a topic of active investigation...
October 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27788497/macrophage-migration-inhibitory-factor-a-potential-driver-and-biomarker-for-head-and-neck-squamous-cell-carcinoma
#15
REVIEW
Sha-Sha Wang, Xiao Cen, Xin-Hua Liang, Ya-Ling Tang
Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27780588/the-non-mammalian-mif-superfamily
#16
REVIEW
Amanda Sparkes, Patrick De Baetselier, Kim Roelants, Carl De Trez, Stefan Magez, Jo A Van Ginderachter, Geert Raes, Richard Bucala, Benoît Stijlemans
Macrophage migration inhibitory factor (MIF) was first described as a cytokine 50 years ago, and emerged in mammals as a pleiotropic protein with pro-inflammatory, chemotactic, and growth-promoting activities. In addition, MIF has gained substantial attention as a pivotal upstream mediator of innate and adaptive immune responses and with pathologic roles in several diseases. Of less importance in mammals is an intrinsic but non-physiologic enzymatic activity that points to MIF's evolution from an ancient defense molecule...
October 12, 2016: Immunobiology
https://www.readbyqxmd.com/read/27771887/macrophage-migration-inhibitory-factor-mif-biological-activities-and-relation-with-cancer
#17
Camila Cristina Guimarães Nobre, Josélio Maria Galvão de Araújo, Thales Allyrio Araújo de Medeiros Fernandes, Ricardo Ney Oliveira Cobucci, Daniel Carlos Ferreira Lanza, Vânia Sousa Andrade, José Veríssimo Fernandes
Macrophage migration inhibitory factor (MIF) emerged in recent years as an important inflammation mediator, playing a prominent role in the pathogenesis of various types of malignant neoplasm. MIF is a glycoprotein that presents a wide spectrum of biological activities and exerts a complex interaction with various cellular signaling pathways, causing imbalance of homeostasis. Experimental and clinical studies show that high levels of MIF are found in almost all types of human cancers and are implicated in seemingly all stages of development of the tumors...
October 23, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27762152/mif-a-controversial-cytokine-a-review-of-structural-features-challenges-and-opportunities-for-drug-development
#18
Joshua Bloom, Shan Sun, Yousef Al-Abed
Macrophage migration inhibitory factor (MIF) has emerged as a promising drug target in diseases including sepsis, rheumatoid arthritis, and cancer. MIF has multiple properties that favor development of specific, targeted therapies: it is expressed broadly among human cells, has noted roles in diverse inflammatory and oncological processes, and has intrinsic enzymatic activity amenable to high-throughput screening. Despite these advantages, anti-MIF therapy remains well behind other cytokine-targeted therapeutics, with no small molecules in the pipeline for clinical development and anti-MIF antibodies only recently beginning clinical trials...
December 2016: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/27761977/concomitant-differentiation-of-a-population-of-mouse-embryonic-stem-cells-into-neuron-like-cells-and-schwann-cell-like-cells-in-a-slow-flow-microfluidic-device
#19
Poornapriya Ramamurthy, Joshua B White, Joong Yull Park, Richard I Hume, Fumi Ebisu, Flor Mendez, Shuichi Takayama, Kate F Barald
BACKGROUND: To send meaningful information to the brain, an inner ear cochlear implant (CI) must become closely coupled to as large and healthy a population of remaining Spiral Ganglion Neurons (SGN) as possible. Inner ear gangliogenesis depends on macrophage migration inhibitory factor (MIF), a directionally attractant neurotrophic cytokine made by both Schwann and supporting cells (Bank et al., 2012). MIF-induced mouse embryonic stem cell (mESC)-derived "neurons" could potentially substitute for lost or damaged SGN...
October 19, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27752708/the-biological-function-and-significance-of-cd74-in-immune-diseases
#20
Huiting Su, Ning Na, Xiaodong Zhang, Yong Zhao
CD74 (MHC class II invariant chain, Ii) is a non-polymorphic type II transmembrane glycoprotein. It is clear that, in addition to be an MHC class II chaperone, CD74 has a diversity of biological functions in physiological and pathological situations. CD74 also participates in other non-MHC II protein trafficking, such as angiotensin II type I receptor. In addition, CD74 is a cell membrane high-affinity receptor for macrophage migration inhibitory factor (MIF), D-dopachrome tautomerase (D-DT/MIF-2) and bacterial proteins...
October 17, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
keyword
keyword
80812
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"