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https://www.readbyqxmd.com/read/28445375/a-new-classification-of-three-dimensional-printing-technologies-systematic-review-of-three-dimensional-printing-for-patient-specific-craniomaxillofacial-surgery
#1
Carly A Jacobs, Alexander Y Lin
BACKGROUND: Three-dimensional printing technology has been advancing in surgical applications. This systematic review examines its patient-specific applications in craniomaxillofacial surgery. METHODS: Terms related to "three-dimensional printing" and "surgery" were searched on PubMed on May 4, 2015; 313 unique articles were returned. Inclusion and exclusion criteria concentrated on patient-specific surgical applications, yielding 141 full-text articles, of which 33 craniomaxillofacial articles were analyzed...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28442772/discriminative-and-distinct-phenotyping-by-constrained-tensor-factorization
#2
Yejin Kim, Robert El-Kareh, Jimeng Sun, Hwanjo Yu, Xiaoqian Jiang
Adoption of Electronic Health Record (EHR) systems has led to collection of massive healthcare data, which creates oppor- tunities and challenges to study them. Computational phenotyping offers a promising way to convert the sparse and complex data into meaningful concepts that are interpretable to healthcare givers to make use of them. We propose a novel su- pervised nonnegative tensor factorization methodology that derives discriminative and distinct phenotypes. We represented co-occurrence of diagnoses and prescriptions in EHRs as a third-order tensor, and decomposed it using the CP algorithm...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438980/host-and-bacterial-factors-control-susceptibility-of-drosophila-melanogaster-to-coxiella-burnetii-infection
#3
Reginaldo G Bastos, Zachary P Howard, Aoi Hiroyasu, Alan G Goodman
Coxiella burnetii is the causative agent of Q fever, a zoonotic disease that threatens both human and animal health. Due to the paucity of experimental animal models, little is known about how host factors interface with bacterial components and affect pathogenesis. Here we used Drosophila melanogaster, in conjunction with the BSL2 Nine Mile phase II (NMII) clone 4 strain of C. burnetii, as a model to investigate host and bacterial components implicated in infection. We demonstrated that adult Drosophila are susceptible to C...
April 24, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28437842/autoimmune-like-chronic-hepatitis-induced-by-olmesartan
#4
Sandrine Barge, Marianne Ziol, Jean-Charles Nault
Drug liver-induced injury (DILI) due to minocyclin, alpha methyldopa or nitrofurantoin may be responsible for chronic liver damage that mimic the biological and/or histological features of chronic autoimmune hepatitis and, in rare cases, progresses to cirrhosis(1). Olmesartan medoxomil is an antihypertensive drug that acts by blocking the angiotensin II receptor and is metabolized into its pharmacologically active form, olmesartan, in the intestine and in the liver before being released into the systemic circulation...
April 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28431561/the-evaluation-of-the-role-of-medial-collateral-ligament-maintaining-knee-stability-by-a-finite-element-analysis
#5
Dong Ren, Yueju Liu, Xianchao Zhang, Zhaohui Song, Jian Lu, Pengcheng Wang
BACKGROUND: A three-dimensional finite element model (FEM) of the knee joint was established to analyze the biomechanical functions of the superficial and deep medial collateral ligaments (MCLs) of knee joints and to investigate the treatment of the knee medial collateral ligament injury. METHODS: The right knee joint of a healthy male volunteer was subjected to CT and MRI scans in the extended position. The scanned data were imported into MIMICS, Geomagic, and ANSYS software to establish a three-dimensional FEM of the human knee joint...
April 21, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28427186/microrna-494-promotes-apoptosis-and-extracellular-matrix-degradation-in-degenerative-human-nucleus-pulposus-cells
#6
Liang Kang, Cao Yang, Yu Song, Kangcheng Zhao, Wei Liu, Wenbin Hua, Kun Wang, Ji Tu, Shuai Li, Huipeng Yin, Yukun Zhang
PURPOSE: This study investigated the expression and function of the microRNA-494 in intervertebral disc degeneration (IDD). RESULTS: MicroRNA-494 expression was upregulated during IDD progression; its overexpression increased the expression of ECM catabolic factors such as matrix metalloproteinase and A disintegrin and metalloproteinase with thrombospondin motif in NP cells while decreasing that of anabolic genes such as type II collagen and aggrecan; it also induced the apoptosis of NP cells, as determined by flow cytometry...
March 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28425134/record-broken-a-copper-peroxide-complex-with-enhanced-stability-and-faster-hydroxylation-catalysis
#7
Sonja Herres-Pawlis, Patricia Liebhäuser, Kristina Keisers, Alexander Hoffmann, Thomas Schnappinger, Isabella Sommer, Anne Thoma, Claudia Wilfer, Roland Schoch, Kai Stührenberg, Matthias Bauer, Maximilian Dürr, Ivana Ivanovic-Burmazovic
Tyrosinase model systems pinpoint pathways to translate nature´s synthetic abilities into useful synthetic catalysts. Mostly, they use N-donor ligands which mimic the histidine residues coordinating the two copper centres. Copper complexes with bis(pyrazolyl)methanes with pyridinyl or imidazolyl moieties are already reported as excellent tyrosinase models. Substitution of the pyridinyl donor results now in the new ligand HC(3 tBuPz)2(4 CO2MePy) which stabilises a room-temperature stable -2:2-peroxide dicopper(II) species upon oxygenation...
April 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28422417/cranial-irradiation-in-childhood-mimicking-neurofibromatosis-type-ii
#8
Felix Bokstein, Tom Dubov, Hagit Toledano-Alhadef, Rinat Bernstein-Molho, Shlomi Constantini, D Gareth Evans, Shay Ben-Shachar
Neurofibromatosis type II (NF2) is a genetic disease characterized by bilateral vestibular schwannomas (VS) and other nerve system tumors. However, such tumors may be associated with environmental, rather than a genetic, etiology. Individuals fulfilling the clinical criteria of NF2 who had been treated by head ionized irradiation at a young age were compared for disease characteristics and molecular analysis with non-irradiated sporadic NF2 cases. In the study cohort, three of 33 sporadic adult cases fulfilling NF2 diagnostic criteria had a history of early age cranial irradiation exposure...
April 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28415777/the-immune-impact-of-mimic-endoscopic-retrograde-appendicitis-therapy-and-appendectomy-on-rabbits-of-acute-appendicitis
#9
Suqin Liu, Fenghua Pei, Xinhong Wang, Deliang Li, Lixia Zhao, Yanyan Song, Zhendong Chen, Bingrong Liu
This study was conducted to evaluate the immune impact of mimic endoscopic retrograde appendicitis therapy and appendectomy on rabbits of acute suppurative appendicitis and to determine whether TLR4/MYD88/NF-κB signaling pathway was activated in this process. 48 rabbits were assigned into 4 groups: group I, the mimic endoscopic retrograde appendicitis therapy group; group II, the appendectomy group; group III, the model group; and group IV, the blank group. White blood cells decreased, while levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, interleukin-4, and interleukin-10 increased on the 2nd day in group I and II...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28408209/role-of-mir-34a-in-tgf-%C3%AE-1-and-drug-induced-epithelial-mesenchymal-transition-in-alveolar-type-ii-epithelial-cells
#10
Mikihisa Takano, Chinami Nekomoto, Masashi Kawami, Ryoko Yumoto
Epithelial-mesenchymal transition (EMT) of alveolar type II epithelial cells may play an important role in the pulmonary fibrosis induced by drugs such as bleomycin (BLM) and methotrexate (MTX). In this study, we examined the role of microRNAs (miRNAs) in drug-induced EMT using RLE/Abca3, a cell line having alveolar type II cell-like phenotype. Based on the screening using miRNA microarray analysis, it was found that the expression of some miRNAs, such as miR-34a, was increased by transforming growth factor (TGF)-β1 and BLM...
April 10, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28405629/human-norovirus-evolution-in-a-chronically-infected-host
#11
Sylvie Y Doerflinger, Stefan Weichert, Anna Koromyslova, Martin Chan, Christian Schwerk, Ruediger Adam, Stefan Jennewein, Grant S Hansman, Horst Schroten
Typically, human noroviruses cause symptoms of acute gastroenteritis for 2 to 4 days. Often, the virions are shed in stool for several days after the symptoms recede, which in turn can lead to further contamination and transmission. Moreover, a number of reports have considered that chronic norovirus infections, i.e., lasting months and years, might even function as reservoirs for the generation of novel strains that can escape the herd immunity or have modified binding interactions with histo-blood group antigens (HBGAs)...
March 2017: MSphere
https://www.readbyqxmd.com/read/28400108/continuum-approximations-for-lattice-free-multi-species-models-of-collective-cell-migration
#12
Oleksii M Matsiaka, Catherine J Penington, Ruth E Baker, Matthew J Simpson
Cell migration within tissues involves the interaction of many cells from distinct subpopulations. In this work, we present a discrete model of collective cell migration where the motion of individual cells is driven by random forces, short range repulsion forces to mimic crowding, and longer range attraction forces to mimic adhesion. This discrete model can be used to simulate a population of cells that is composed of K ≥ 1 distinct subpopulations. To analyse the discrete model we formulate a hierarchy of moment equations that describe the spatial evolution of the density of agents, pairs of agents, triplets of agents, and so forth...
April 8, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28389707/the-race-of-10-synthetic-rnai-based-drugs-to-the-pharmaceutical-market
#13
REVIEW
Ricardo Titze-de-Almeida, Catherine David, Simoneide Souza Titze-de-Almeida
Ten years after Fire and Melo's Nobel Prize for discovery of gene silencing by double-stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes in the chemical structure of synthetic oligonucleotides make them more stable and specific, and new delivery strategies became progressively available. The attention of pharmaceutical industry rapidly turned to RNAi, as an opportunity to explore new drug targets. This review addresses nine small-interfering RNAs (siRNAs) and one unique microRNA (miRNA) inhibitor, which entered the phase 2-3 clinical trials...
April 7, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28386165/effect-of-antipyretic-therapy-on-mortality-in-critically-ill-patients-with-sepsis-receiving-mechanical-ventilation-treatment
#14
Sheng Ye, Dan Xu, Chenmei Zhang, Mengyao Li, Yanyi Zhang
Purpose. The study aimed to investigate the effectiveness of antipyretic therapy on mortality in critically ill patients with sepsis requiring mechanical ventilation. Methods. In this study, we employed the multiparameter intelligent monitoring in intensive care II (MIMIC-II) database (version 2.6). All patients meeting the criteria for sepsis and also receiving mechanical ventilation treatment were included for analysis, all of whom suffer from fever or hyperthermia. Logistic regression model and R language (R version 3...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28386058/cartilage-tissue-engineering-by-the-3d-bioprinting-of-ips-cells-in-a-nanocellulose-alginate-bioink
#15
Duong Nguyen, Daniel A Hägg, Alma Forsman, Josefine Ekholm, Puwapong Nimkingratana, Camilla Brantsing, Theodoros Kalogeropoulos, Samantha Zaunz, Sebastian Concaro, Mats Brittberg, Anders Lindahl, Paul Gatenholm, Annika Enejder, Stina Simonsson
Cartilage lesions can progress into secondary osteoarthritis and cause severe clinical problems in numerous patients. As a prospective treatment of such lesions, human-derived induced pluripotent stem cells (iPSCs) were shown to be 3D bioprinted into cartilage mimics using a nanofibrillated cellulose (NFC) composite bioink when co-printed with irradiated human chondrocytes. Two bioinks were investigated: NFC with alginate (NFC/A) or hyaluronic acid (NFC/HA). Low proliferation and phenotypic changes away from pluripotency were seen in the case of NFC/HA...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28374736/biomimetic-catalytic-transformation-of-toxic-%C3%AE-oxoaldehydes-to-high-value-chiral-%C3%AE-hydroxythioesters-using-artificial-glyoxalase-i
#16
Sang Yeon Park, In-Soo Hwang, Hyun-Ju Lee, Choong Eui Song
Glyoxalase I plays a critical role in the enzymatic defence against glycation by catalysing the isomerization of hemithioacetal, formed spontaneously from cytotoxic α-oxoaldehydes and glutathione, to (S)-α-hydroxyacylglutathione derivatives. Upon the hydrolysis of the thioesters catalysed by glyoxalase II, inert (S)-α-hydroxy acids, that is, lactic acid, are then produced. Herein, we demonstrate highly enantioselective glyoxalase I mimic catalytic isomerization of in-situ-generated hemithioacetals, providing facile access to both enantiomers of α-hydroxy thioesters...
April 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28368063/dual-stimuli-responsive-injectable-microgel-solid-drug-nanoparticle-nanocomposites-for-release-of-poorly-soluble-drugs
#17
Adam R Town, Marco Giardiello, Rohan Gurjar, Marco Siccardi, Michael E Briggs, Riaz Akhtar, Tom O McDonald
An in situ forming implant (ISFI) for drug delivery combines the potential to improve therapeutic adherence for patients with simple administration by injection. Herein, we describe the preparation of an injectable nanocomposite ISFI composed of thermoresponsive poly(N-isopropylacrylamide) based microgels and solid drug nanoparticles. Monodisperse poly(N-isopropylacrylamide) or poly(N-isopropylacrylamide-co-allylamine) microgels were prepared by precipitation polymerisation with mean diameters of approximately 550 nm at 25 °C...
April 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28365190/-kikuchi-fujimoto-disease-mimicking-malignant-lymphoma-in-adolescents
#18
A Escudier, S Courbage, V Meignin, S Abbou, S Sauvion, M Houlier, A Galerne, J Gaudelus, L de Pontual, M Simonin
Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is a rare cause of lymphadenopathy in children. This benign disease can mimic lymphoma and misleads doctors. It was first described in Asia, where it occurred especially in young women. Recent publications show that it can also affect teenagers and young adults in Caucasian populations. The pathophysiology remains unknown. Three hypotheses have been raised for this disease: the role of viruses (in particular HHV-8), genetic predisposition (two alleles in HLA class II genes were found more frequently in patients with Kikuchi disease), and an autoimmune cause because of the correlation with lupus erythematosus...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28363153/structure-activity-study-of-carbonic-anhydrase-ix-selective-inhibition-with-ureido-substituted-benzenesulfonamides
#19
Mam Y Mboge, Brian P Mahon, Nicole Lamas, Lillien Socorro, Fabrizio Carta, Claudiu T Supuran, Susan C Frost, Robert McKenna
Ureido-substituted benzenesulfonamides (USBs) show great promise as selective and potent inhibitors for human carbonic anhydrase hCA IX and XII, with one such compound (SLC-0111/U-F) currently in clinical trials (clinical trials.gov, NCT02215850). In this study, the crystal structures of both hCA II (off-target) and an hCA IX-mimic (target) in complex with selected USBs (U-CH3, U-F, and U-NO2), at resolutions of 1.9 Å or better, are presented, and demonstrate differences in the binding modes within the two isoforms...
March 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28357693/arachis-hypogaea-l-produces-mimic-and-inhibitory-quorum-sensing-like-molecules
#20
F Nievas, L Vilchez, W Giordano, P Bogino
A wide variety of plant-associated soil bacteria (rhizobacteria) communicate with each other by quorum sensing (QS). Plants are able to detect and produce mimics and inhibitor molecules of the QS bacterial communicative process. Arachis hypogaea L. (peanut) establishes a nitrogen-fixing symbiosis with rhizobia belonging to the genus Bradyrhizobium. These bacteria use a QS mechanism dependent on the synthesis of N-acyl homoserine lactones (AHLs). Given the relevance that plant-rhizobacteria interactions have at the ecological level, this work addresses the involvement of peanut in taking part in the QS mechanism...
March 29, 2017: Antonie Van Leeuwenhoek
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