keyword
MENU ▼
Read by QxMD icon Read
search

MIMIC II

keyword
https://www.readbyqxmd.com/read/29144738/metabolism-of-an-insecticide-fenitrothion-by-cunninghamella-elegans-atcc36112
#1
Yong-Zhe Zhu, Min Fu, In-Hong Jeong, Jeong-Han Kim, Chuan-Jie Zhang
In this study, the detailed metabolic pathways of fenitrothion (FNT), an organophosphorus insecticide by Cunninghamella elegans was investigated. Approximately 81% of FNT was degraded within 5 d after treatment with concomitant accumulation of four metabolites (M1-M4). The four metabolites were separated by HPLC and their structures were identified by MS and/or NMR. M3 is confirmed to be an initial precursor of others and identified as fenitrothion-oxon (FNTO). On the basis of their metabolic profiling, the possible metabolic pathways involved in phase I and II metabolism of FNT by C...
November 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29138833/mir-16-mimics-inhibit-tgf-%C3%AE-1-induced-epithelial-to-mesenchymal-transition-via-activation-of-autophagy-in-non-small-cell-lung-carcinoma-cells
#2
Hui Wang, Ying Zhang, Qian Wu, Yong-Bin Wang, Wei Wang
Autophagy is critical for the metastasis of cancer cells through induction of epithelial-to-mesenchymal transition (EMT). Activation of TGF-β signaling plays a key role in regulating autophagy. miR-16 may be associated with non-small cell lung carcinoma (NSCLC) progression. However, the role of miR-16 in NSCLC cell autophagy in the presence of TGF-β and the underlying mechanism are still unclear. To test whether miR-16 targets ATG3 which is involved in autophagy of NSCLC cells, we studied the expression levels of miR-16 and ATG3 in NSCLC patients, verified the targeting of ATG3 by miR-16 by luciferase reporter gene system, and investigated the role of miR-16 in the autophagy of NSCLC cells...
November 9, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29137484/the-role-of-endogenous-reactive-oxygen-species-in-cardiac-myocyte-autophagy
#3
J-P Wang, R-F Chi, J Liu, Y-Z Deng, X-B Han, F-Z Qin, B Li
Autophagy is implicated in the maintenance of cardiac homeostasis. Autophagy is activated in heart failure, in which reactive oxygen species (ROS) are increased. Exogenous ROS have been shown to induce cardiomyocyte autophagy alterations. However, little is known about the influences of physiological levels of endogenous ROS on cardiomyocyte autophagy. In the present study, we tested the hypothesis that endogenous ROS in cardiomyocytes play an important role in inducing autophagy. Cultured H9C2 cardiomyocytes or Sprague-Dawley rats were treated with the antioxidant N-acetyl-cysteine (NAC) or the superoxide dismutase mimic tempol under the basal or nutrient deprivation conditions...
November 10, 2017: Physiological Research
https://www.readbyqxmd.com/read/29136883/programmable-fow-injection-principle-methodology-and-application-for-trace-analysis-of-iron-in-a-sea-water-matrix
#4
Mariko Hatta, Christopher I Measures, Jaromir Jarda Ruzicka
Automation of reagent based assays by Flow Injection is based on sample processing, in which a sample flows continuously towards and through a detector for monitoring of its components. There are three drawbacks to using this approach. The constant continuous forward flow: continually consumes reagents and generates chemical waste and necessitates a compromise when optimizing the performance of the reagent based assay. The reason is that individual steps of an assay protocol, i.e., sample and reagent metering, mixing, incubation, monitoring and efficient washout are carried out most efficiently on different time scales and therefore at different flowrates...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29133896/the-food-borne-pathogen-campylobacter-jejuni-responds-to-the-bile-salt-deoxycholate-with-countermeasures-to-reactive-oxygen-species
#5
Nicholas M Negretti, Christopher R Gourley, Geremy Clair, Joshua N Adkins, Michael E Konkel
Bile plays an important role in digestion, absorption of fats, and the excretion of waste products, while concurrently providing a critical barrier against colonization by harmful bacteria. Previous studies have demonstrated that gut pathogens react to bile by adapting their protein synthesis. The ability of pathogens to respond to bile is remarkably complex and still incompletely understood. Here we show that Campylobacter jejuni, a leading bacterial cause of human diarrheal illness worldwide, responds to deoxycholate, a component of bile, by altering global gene transcription in a manner consistent with a strategy to mitigate exposure to reactive oxygen stress...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29132626/early-hospital-mortality-prediction-of-intensive-care-unit-patients-using-an-ensemble-learning-approach
#6
Aya Awad, Mohamed Bader-El-Den, James McNicholas, Jim Briggs
BACKGROUND: Mortality prediction of hospitalized patients is an important problem. Over the past few decades, several severity scoring systems and machine learning mortality prediction models have been developed for predicting hospital mortality. By contrast, early mortality prediction for intensive care unit patients remains an open challenge. Most research has focused on severity of illness scoring systems or data mining (DM) models designed for risk estimation at least 24 or 48h after ICU admission...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29131958/design-synthesis-and-biological-assessment-of-biased-allosteric-modulation-of-the-urotensin-ii-receptor-using-achiral-1-3-4-benzotriazepin-2-one-turn-mimics
#7
Antoine Douchez, Étienne Billard, Terence Hébert, David Chatenet, William D Lubell
Benzotriazepin-2-ones were designed to mimic the suggested bioactive γ-turn conformation of the Bip-Lys-Tyr tripeptide in Urocontrin ([Bip(4)]URP), which modulates the urotensin II receptor (UT) and differentiates the effects of the endogenous ligands urotensin II (UII) and urotensin II-related peptide (URP). Twenty-six benzotriazepin-2-ones were synthesized by acylation of anthranilate-derived amino ketones with an aza-glycine equivalent, chemoselective nitrogen functionalization and ring closure. Several mimics exhibited selective modulatory effects on hUII- and URP-associated vasoconstriction in an ex-vivo rat aortic ring bioassay...
November 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29128538/hyaluronan-size-alters-chondrogenesis-of-adipose-derived-stem-cells-via-the-cd44-erk-sox-9-pathway
#8
Shun-Cheng Wu, Chung-Hwan Chen, Jyun-Ya Wang, Yi-Shan Lin, Je-Ken Chang, Mei-Ling Ho
Hyaluronan (HA) is a natural linear polymer that is one of the main types of extracellular matrix during the early stage of chondrogenesis. We found that the chondrogenesis of adipose-derived stem cells (ADSCs) can be initiated and promoted by the application of HA to mimic the chondrogenic niche. The aim of this study is to investigate the optimal HA molecular weight (Mw) for chondrogenesis of ADSCs and the detailed mechanism. In this study, we investigated the relationships among HA Mw, CD44 clustering, and the extracellular signal-regulated kinase (ERK)/SOX-9 pathway during chondrogenesis of ADSCs...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29123977/sodium-hydrosulfide-attenuates-cerebral-ischemia-reperfusion-injury-by-suppressing-overactivated-autophagy-in-rats
#9
Wen-Wu Jiang, Bai-Sheng Huang, Yang Han, Lv-Hong Deng, Li-Xiang Wu
Ischemic stroke is a leading cause of death and disability worldwide, and autophagy may be involved in the pathological process of cerebral ischemia/reperfusion injury. Hydrogen sulfide (H2S) is an endogenous gasotransmitter with protective effects against multiple diseases. Here, we tested the effect of H2S on cerebral ischemia/reperfusion injury in rats. Sodium hydrosulfide (NaHS), an H2S donor, improved neurological function and reduced the size of the infarcts induced by transient middle cerebral artery occlusion (MCAO) followed by reperfusion in rats...
November 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29115479/overexpression-of-mir%C3%A2-185-inhibits-autophagy-and-apoptosis-of-dopaminergic-neurons-by-regulating-the-ampk-mtor-signaling-pathway-in-parkinson-s-disease
#10
Zhi Wen, Jie Zhang, Peng Tang, Ning Tu, Ke Wang, Guangyao Wu
Parkinson's disease (PD) is an age‑associated neurodegenerative disorder characterized by the death of dopaminergic neurons in the substantia nigra pars compacta. Activation of 5'‑adenosine monophosphate‑activated protein kinase (AMPK) has been suggested to be associated with PD pathogenesis. The aim of the present study was to investigate the effects of the aberrant expression of microRNA‑185 (miR‑185) in PD. A 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine (MPTP)‑induced in vitro model of PD was generated using the human SH‑SY5Y dopaminergic neuroblastoma cell line, in order to examine the potential molecular mechanisms underlying the roles of miR‑185 in PD...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29111583/from-peptide-fragments-to-whole-protein-copper-ii-load-and-coordination-features-of-iapp
#11
Antonio Magrì, Adriana Pietropaolo, Giovanni Tabbì, Diego La Mendola, Enrico Rizzarelli
The copper binding features of rat islet amyloid polypeptide (r-IAPP) are herein disclosed through the determination of the stability constants and spectroscopic properties of its copper complex species. To mimic the metal binding sites of the h-IAPP, a soluble, single point mutated having a histidine residue in place of Arg18 was synthesized, i.e. r-IAPP(1-37;R18H). The peptide IAPP(1-8) was also characterized to have deeper insight into the N-terminus copper(II) binding features of r-IAPP as well as of its mutated form...
November 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29111510/cation-tautomerism-twinning-and-disorder-in-the-triclinic-and-monoclinic-forms-of-4-amino-5-chloro-2-6-dimethylpyrimidinium-5-chloro-2-hydroxybenzoate-and-a-new-disordered-refinement-of-2-amino-4-6-dimethoxypyrimidin-1-ium-thiophene-2-carboxylate
#12
Ammaiyappan Rajam, P Thomas Muthiah, Ray J Butcher, Jerry P Jasinski, Christopher Glidewell
Pyrimidines are important compounds in biology and medicine, and the aminopyrimidine fragment can be identified in three of the four bases in DNA. The targeted drug action of pharmaceuticals containing this functionality is likely to depend heavily on molecular recognition processes involving hydrogen bonding. Crystallization of an equimolar mixture of 4-amino-5-chloro-2,6-dimethylpyrimidine and 5-chloro-2-hydroxybenzoic acid yielded two forms of the 1:1 salt, C6H9ClN3(+)·C7H4ClO3(-), each containing a different tautomeric form of the cation...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29100154/oxytocin-plasma-levels-predict-the-outcome-of-psychotherapy-a-pilot-study-in-chronic-depression
#13
A Jobst, L Sabaß, D Hall, B Brücklmeier, A Buchheim, J Hall, N Sarubin, P Zill, P Falkai, E-L Brakemeier, F Padberg
BACKGROUND: Oxytocin is associated with bonding and social deficits in psychiatric disorders and has also been discussed as a potential therapeutic intervention to augment psychotherapy. The Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a specific form of psychotherapy for chronic depression, an illness in which interpersonal deficits play a major role. In this pilot study, we investigated whether Oxytocin plasma levels predict the clinical outcome of chronic depressive patients after CBASP...
October 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29099857/knockout-of-apolipoprotein-e-in-rabbit-promotes-premature-intervertebral-disc-degeneration-a-new-in-vivo-model-for-therapeutic-approaches-of-spinal-disc-disorders
#14
Anja Beierfuß, Hermann Dietrich, Christian Kremser, Monika Hunjadi, Andreas Ritsch, Thomas Rülicke, Claudius Thomé, Demissew Shenegelegn Mern
Intervertebral disc (IVD) degeneration that accelerates the loss of disc structural and functional integrities is recognized as one of the major factors of chronic back pain. Cardiovascular risk factors, such as deficits of apolipoproteins that elevate the levels of cholesterol and triglycerides, are considered critical for the progress of atherosclerosis; notably in the abdominal aorta and its lumbar branching arteries that supply lumbar vertebrae and IVDs. Obstruction of the lumbar arteries by atherosclerosis is presumed to promote lumbar disc degeneration and low back pain...
2017: PloS One
https://www.readbyqxmd.com/read/29098117/human-chorionic-gonadotropin-mediated-generation-of-reactive-oxygen-species-is-sufficient-to-induce-meiotic-exit-but-not-apoptosis-in-rat-oocytes
#15
Meenakshi Tiwari, Shail K Chaube
Generation of reactive oxygen species (ROS) is associated with final stages of follicular development and ovulation in mammals. The human chorionic gonadotropin (hCG) mimics the action of luteinizing hormone and triggers follicular development and ovulation. However, it remains unclear whether hCG induces generation of ROS, if yes, whether hCG-mediated increased level of ROS could induce meiotic exit and/or apoptosis in rat oocytes. For this purpose, cumulus-oocyte complexes (COCs) were collected from ovary of experimental rats injected with 20 IU pregnant mare's serum gonadotropin for 48 h followed by 20 IU hCG for 0, 7, 14, and 21 h...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/29096944/an-in-vitro-inflammation-model-to-study-the-nrf2-and-nf-%C3%AE%C2%BAb-crosstalk-in-presence-of-ferulic-acid-as-modulator
#16
Nadia Lampiasi, Giovanna Montana
The aim of this study was to evaluate the crosstalk between Nrf2 and NF-κB signaling pathways and to explore the modulating activity actuated by ferulic acid. In the inflammation process, a key player is the nuclear factor-κB (NF-κB) transcription factor pathway. On the contrary, the activation of Nrf2 inhibits inflammation and impairs degenerative disease providing an interface between redox and anti-inflammatory responses. Recent studies have demonstrated that protein phosphorylation of IKK complex is a potential mechanism for the activation of both Nrf2 and NF-κB pathways...
October 27, 2017: Immunobiology
https://www.readbyqxmd.com/read/29094793/encapsulation-of-a-quinhydrone-cofactor-in-the-inner-pocket-of-cobalt-triangular-prisms-combined-light-driven-reduction-of-protons-and-hydrogenation-of-nitrobenzene
#17
Liang Zhao, Jianwei Wei, Jing Zhang, Cheng He, Chunying Duan
The design of artificial systems that mimic highly evolved and finely tuned natural photosynthetic systems has attracted intensive research interest. A new system was formulated that encapsulates a quinhydrone (QHQ) cofactor in metal-organic hosts based on inspiration from the redox relays of photosystem II. The M6 L3 triangular prism hosts provided a special redox-modulated environment for the cofactor localized within the pocket, and the proximity effects of the host-guest interactions facilitated the formation of charge-transfer complexes that are typically very difficult to form in normal homogeneous systems...
November 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29078951/instrumentation-and-applications-of-electrochemistry-coupled-to-mass-spectrometry-for-studying-xenobiotic-metabolism-a-review
#18
REVIEW
Lenka Portychová, Kevin A Schug
The knowledge of metabolic pathways and biotransformation of xenobiotics, artificial substances foreign to the entire biological system, is crucial for elucidation of degradation routes of potentially toxic substances. Nowadays, there are many methods to simulate xenobiotic metabolism in the human body in vitro. In this review, the metabolism of various substances in the human body is described, followed by a summary of methods used for prediction of metabolic pathways and biotransformation. Above all, focus is placed on the coupling of electrochemistry to mass spectrometry, which is still a relatively new technique...
November 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29077845/direct-actions-of-androgen-estrogen-and-anti-m%C3%A3-llerian-hormone-on-primate-secondary-follicle-development-in-the-absence-of-fsh-in-vitro
#19
T Baba, A Y Ting, O Tkachenko, J Xu, R L Stouffer
STUDY QUESTION: What are effects of androgen, estrogen and anti-Müllerian hormone (AMH), independent of FSH action, on the development and function of primate follicles from the preantral to small antral stage in vitro? SUMMARY ANSWER: Androgen and estrogen, but not AMH, promote follicle survival and growth in vitro, in the absence of FSH. However, their growth-promoting effects are limited to the preantral to early antral stage. WHAT IS KNOWN ALREADY: FSH supports primate preantral follicle development in vitro...
October 25, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29073549/gastric-outlet-obstruction-by-a-lost-gallstone-case-report-and-literature-review
#20
Jennifer Koichopolos, Moska Hamidi, Matthew Cecchini, Kenneth Leslie
INTRODUCTION: Spilled gallstones from a laparoscopic cholecystectomy can be a source of significant morbidity, most commonly causing abscesses and fistulae. Preventative measures for loss, careful removal during the initial surgery, and good documentation of any concern for remaining intraperitoneal stones needs to be performed with the initial surgery. CASE REPORT: An 80-year-old male with a history of complicated biliary disease resulting in a cholecystectomy presented to general surgery clinic with increasing symptoms of gastric outlet obstruction...
October 17, 2017: International Journal of Surgery Case Reports
keyword
keyword
8081
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"