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MIMIC II

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https://www.readbyqxmd.com/read/28921879/natural-and-artificial-mn4ca-cluster-for-water-splitting-reaction
#1
Chunxi Zhang, Changhui Chen, Yanxi Li, Guoqing Zhao, Ruoqing Yao
The oxygen-evolving center (OEC) in photosystem II (PSII) is a unique biological catalyst that splits water into electrons, protons and O2 by using solar energy. Recent crystallographic studies have revealed that the structure of the OEC is an asymmetric Mn4Ca-cluster, which provides a blueprint to develop man-made water-splitting catalysts in artificial photosynthesis. Although it is a great challenge to mimic the whole structure and function of the OEC in the laboratory, significant advances have recently been achieved...
September 17, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28920698/correlating-bridging-ligand-with-properties-of-ligand-templated-mn-ii-3x3-3-clusters-x-br-cl-h-meo
#2
Kevin J Anderton, David M Ermert, Pedro A Quintero, Mackenzie W Turvey, Majed S Fataftah, Khalil A Abboud, Mark W Meisel, Erik Čižmár, Leslie J Murray
Polynuclear manganese compounds have garnered interest as mimics and models of the water oxidizing complex (WOC) in photosystem II and as single molecule magnets. Molecular systems in which composition can be correlated to physical phenomena, such as magnetic exchange interactions, remain few primarily because of synthetic limitations. Here, we report the synthesis of a family of trimanganese(II) complexes of the type Mn3X3L (X = Cl(-), H(-), and MeO(-)) where L(3-) is a tris(β-diketiminate) cyclophane. The tri(chloride) complex (2) is structurally similar to the reported tri(bromide) complex (1) with the Mn3X3 core having a ladder-like arrangement of alternating M-X rungs, whereas the tri(μ-hydride) (3) and tri(μ-methoxide) (4) complexes contain planar hexagonal cores...
September 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28919454/a-robust-immune-system-conditions-the-response-to-abagovomab-anti-idiotypic-monoclonal-antibody-mimicking-the-ca125-protein-vaccination-in-ovarian-cancer-patients
#3
Alessandra Battaglia, Marco Fossati, Alexia Buzzonetti, Giovanni Scambia, Andrea Fattorossi
INTRODUCTION: Despite encouraging phase I and II study results, vaccination of ovarian cancer patients with abagovomab - an anti-idiotypic mAb that mimics the ovarian cancer CA125 protein - failed to demonstrate efficacy in the phase III trial named MIMOSA (NCT00418574). We postulated that in this trial patients with a more robust immune system did respond to abagovomab but went undetected among a larger number of non-responders. We also postulated that assessment of the immune system status ahead of abagovomab administration might predict patients' propensity to respond to abagovomab...
September 14, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28919412/the-conformation-change-and-tumor-suppressor-role-of-merlin-are-both-independent-of-serine-518-phosphorylation
#4
Wancai Xing, Meng Li, Fayou Zhang, Xing Ma, Jiafu Long, Hao Zhou
Merlin functions as a tumor suppressor and suppresses malignant activity of cancer cells through multiple mechanisms. However, whether Serine 518 phosphorylation regulates the conformation of Merlin as well as the open-closed conformational changes affect Merlin's tumor inhibitory activity remain controversial. In this study, we used different mutants to mimic related conformational states of Merlin and investigated its physiological functions. Our results showed that the phosphorylation at Serine 518 has no influence on Merlin's conformation, subcellular localization, or cell proliferation inhibitory activity...
September 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28905327/development-of-a-mini-freeze-dryer-for-material-sparing-laboratory-processing-with-representative-product-temperature-history
#5
Wasfy M Obeidat, Ekneet Sahni, William Kessler, Michael Pikal
The goal of the work described in this publication was to evaluate a new, small, material-sparing freeze dryer, denoted as the "mini-freeze dryer or mini-FD", capable of reproducing the product temperature history of larger freeze dryers, thereby facilitating scale-up. The mini-FD wall temperatures can be controlled to mimic loading procedures and dryer process characteristics of larger dryers. The mini-FD is equipped with a tunable diode laser absorption spectroscopy (TDLAS) water vapor mass flow monitor and with other advanced process analytical technology (PAT) sensors...
September 13, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28899883/microrna-146a-mimics-reduce-the-peripheral-neuropathy-in-type-ii-diabetic-mice
#6
Xian Shuang Liu, Baoyan Fan, Alexandra Szalad, Longfei Jia, Lei Wang, Xinli Wang, Wanlong Pan, Li Zhang, Ruilan Zhang, Jiani Hu, Xiao Ming Zhang, Michael Chopp, Zheng Gang Zhang
MicroRNA-146a (miR-146a) regulates multiple immune diseases. However, the role of miR-146a in diabetic peripheral neuropathy (DPN) has not been investigated. We found that mice (db/db) with type II diabetes exhibited substantial down-regulation of miR-146a in sciatic nerve tissue. Systemic administration of miR-146a mimics to diabetic mice elevated miR-146a levels in plasma and sciatic nerve tissue and substantially increased motor and sensory nerve conduction velocities by 29% and 11%, respectively, and regional blood flow by 50% in sciatic nerve tissue...
September 12, 2017: Diabetes
https://www.readbyqxmd.com/read/28894111/induction-of-high-titred-non-neutralising-antibodies-by-self-adjuvanting-peptide-epitopes-derived-from-the-respiratory-syncytial-virus-fusion-protein
#7
Noushin Jaberolansar, Keith J Chappell, Daniel Watterson, Imogen M Bermingham, Istvan Toth, Paul R Young, Mariusz Skwarczynski
Respiratory syncytial virus (RSV) causes severe lower respiratory tract illness in infants and young children. The significant morbidity and mortality rates associated with RSV infection make an effective RSV vaccine development a priority. Two neutralising antibody binding sites, Ø and II, located on the pre-fusion RSV F glycoprotein are prime candidates for epitope-focused vaccine design. We report on a vaccine strategy that utilises a lipid core peptide (LCP) delivery system with self-adjuvanting properties in conjunction with either the antigenic site Ø or II (B cell epitopes) along with PADRE as a T helper cell epitope...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28888077/microrna-214-3p-a-link-between-autophagy-and-endothelial-cell-dysfunction-in-atherosclerosis
#8
Jing Wang, Wei-Na Wang, Shuang-Bin Xu, Hong Wu, Bing Dai, Dong-Dong Jian, Mei Yang, Yu-Tao Wu, Qiang Feng, Jian-Hua Zhu, Lei Zhang, Li Zhang
AIM: Endothelial cell injury assumes a fundamental part in the pathogenesis of atherosclerosis, and endothelial cell autophagy has protective effects on the development of atherosclerosis, though the underlying molecular regulation mechanism is indistinct. This study is aimed to investigate whether microRNA-214-3p (miR-214-3p) is involved in the endothelial cell autophagy regulation of atherosclerosis. METHODS: We utilized ApoE-/- mice provided with a high-fat diet (HFD) as atherosclerosis model...
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28882574/kupffer-cells-activation-promoted-binge-drinking-induced-fatty-liver-by-activating-lipolysis-in-white-adipose-tissues
#9
Yu-Ying Zhao, Rui Yang, Mo Xiao, Min-Jie Guan, Ning Zhao, Tao Zeng
Kupffer cells (KCs) have been suggested to play critical roles in chronic ethanol induced early liver injury, but the role of KCs in binge drinking-induced hepatic steatosis remains unclear. This study was designed to investigate the roles of KCs inhibitor (GdCl3) and TNF-α antagonist (etanercept) on binge drinking-induced liver steatosis and to explore the underlying mechanisms. C57BL/6 mice were exposed to three doses of ethanol (6g/kg body weight) to mimic binge drinking-induced fatty liver. The results showed that both GdCl3 and etanercept partially but significantly alleviated binge drinking-induced increase of hepatic triglyceride (TG) level, and reduced fat droplets accumulation in mice liver...
September 4, 2017: Toxicology
https://www.readbyqxmd.com/read/28878070/effect-of-the-phosphorylation-of-the-cm2-protein-on-influenza-c-virus-replication
#10
Takanari Goto, Yoshitaka Shimotai, Yoko Matsuzaki, Yasushi Muraki, Ri Sho, Kanetsu Sugawara, Seiji Hongo
CM2 is the second membrane protein of the influenza C virus and has been demonstrated to play a role in the uncoating and genome packaging processes in influenza C virus replication. Although the effects of N-linked glycosylation, disulfide-linked oligomerization, and palmitoylation of CM2 on virus replication have been analyzed, the effect of the phosphorylation of CM2 on virus replication remains to be determined. In this study, phosphorylation site(s) at residues 78 and/or 103 of CM2 were substituted with alanine residue(s) and the effects of the loss of phosphorylation on influenza C virus replication were analyzed...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28871076/knockdown-of-microrna-122-protects-h9c2-cardiomyocytes-from-hypoxia-induced-apoptosis-and-promotes-autophagy
#11
Zaiwei Zhang, Hu Li, Shasha Chen, Ying Li, Zhiyuan Cui, Jie Ma
BACKGROUND Acute myocardial infarction (AMI) is a severe disease causing heart failure and sudden death. Studies indicate that microRNAs (miRNAs) are involved in the pathophysiology of AMI. In the present study, we carefully explored the effects of miR-122 on myocardial hypoxia injury and its possible underlying mechanism. MATERIAL AND METHODS miR-122 expression was analyzed in H9c2 cardiomyocytes after being transfected with miR-122 mimic, ASO-miR-122, or negative control. Cell viability and apoptosis were investigated by CCK-8 assays and flow cytometry analysis, respectively...
September 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28868535/configurable-microfluidic-platform-for-investigating-therapeutic-delivery-from-biomedical-device-coatings
#12
Zidong Li, Erkin Seker
Advanced biomedical device coatings have shown significant promise in delivery of therapeutics (e.g., small-molecule drugs, proteins) for a wide range of medical interventions ranging from targeted cancer therapy to management of atherosclerosis. In order to accelerate the development of such coatings, there is a need for tools to investigate the loading capacity and release kinetics with high temporal resolution and in a variety of physiological conditions. To address this need, we report a microfluidic platform, where the coating on a substrate can be mounted onto the microchannel and the device can be configured in two physiologically-relevant modes: (i) flow-mode allows for monitoring the release from the coating in contact with a liquid flowing at a specific rate, modeling the case of a drug-eluting stent...
September 4, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28867969/an-overview-of-achalasia-and-its-subtypes
#13
Dhyanesh A Patel, Brian M Lappas, Michael F Vaezi
Achalasia is one of the most studied esophageal motility disorders. However, the pathophysiology and reasons that patients develop achalasia are still unclear. Patients often present with dysphagia to solids and liquids, regurgitation, and varying degrees of weight loss. There is significant latency prior to diagnosis, which can have nutritional implications. The diagnosis is suspected based on clinical history and confirmed by esophageal high-resolution manometry testing. Esophagogastroduodenoscopy is necessary to rule out potential malignancy that can mimic achalasia...
July 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28865306/natural-ecosystem-mimicry-in-traditional-dryland-agroecosystems-insights-from-an-empirical-and-holistic-approach
#14
Julien Blanco, Geneviève Michon, Stéphanie M Carrière
While the aim of Ecological Intensification is to enable the design of more sustainable and productive agricultural systems, it is not suited to dryland agroecosystems that are driven by non-equilibrium dynamics and intrinsic variability. Instead, a model based on mobility and variability management has been proposed for these agroecosystems. However, this model remains under-applied in southern Morocco where there have been few studies on the functioning of traditional agroecosystems. This paper focuses on an agroecosystem in the Moroccan Saharan fringe zone that combines agriculture and pastoralism in an acacia parkland...
August 30, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28861389/cone-beam-computed-tomographic-evaluation-of-the-temporomandibular-joint-and-dental-characteristics-of-patients-with-class-ii-subdivision-malocclusion-and-asymmetry
#15
Mingna Huang, Yun Hu, Jinfeng Yu, Jicheng Sun, Ye Ming, Leilei Zheng
OBJECTIVE: Treating Class II subdivision malocclusion with asymmetry has been a challenge for orthodontists because of the complicated characteristics of asymmetry. This study aimed to explore the characteristics of dental and skeletal asymmetry in Class II subdivision malocclusion, and to assess the relationship between the condyle-glenoid fossa and first molar. METHODS: Cone-beam computed tomographic images of 32 patients with Class II subdivision malocclusion were three-dimensionally reconstructed using the Mimics software...
September 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28857176/do-right-ventricular-trabeculae-gain-energetic-advantage-from-having-a-greater-velocity-of-shortening
#16
Toan Pham, June-Chiew Han, Andrew Taberner, Denis Loiselle
Our study aimed to ascertain whether the interventricular difference of shortening velocity, reported for isolated cardiac tissues in vitro, affects interventricular mechano-energetic performance when tested under physiological conditions using a shortening protocol designed to mimic those in vivo. We isolated trabeculae from both ventricles of the rat, mounted them in a calorimeter, and performed experiments at 37°C and 5 Hz stimulus frequency to emulate conditions of the rat heart in vivo. Each trabecula was subjected to two experimental protocols: (i) isotonic work-loop contractions at a variety of afterloads, and (ii) isometric contractions at a variety of preloads...
August 30, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28854438/down-regulation-of-lncrna-malat1-attenuates-neuronal-cell-death-through-suppressing-beclin1-dependent-autophagy-by-regulating-mir-30a-in-cerebral-ischemic-stroke
#17
Dong Guo, Ji Ma, Lei Yan, Tengfei Li, Zhiguo Li, Xinwei Han, Shaofeng Shui
BACKGROUND/AIMS: LncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be highly expressed in an in vitro mimic of ischemic stroke conditions. However, the exact biological role of MALAT1 and its underlying mechanism in ischemic stroke remain to be elucidated. METHODS: The roles of MALAT1 and miR-30a on cell death and infarct volume and autophagy were evaluated in experimental ischemic stroke. The relationships between miR-30a and MALAT1, Beclin1 were confirmed by luciferase reporter assay...
August 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28851393/pattern-ii-and-pattern-iii-ms-are-entities-distinct-from-pattern-i-ms-evidence-from-cerebrospinal-fluid-analysis
#18
S Jarius, F B König, I Metz, K Ruprecht, F Paul, W Brück, B Wildemann
BACKGROUND: The diagnosis of multiple sclerosis (MS) is currently based solely on clinical and magnetic resonance imaging features. However, histopathological studies have revealed four different patterns of lesion pathology in patients diagnosed with MS, suggesting that MS may be a pathologically heterogeneous syndrome rather than a single disease entity. OBJECTIVE: The aim of this study was to investigate whether patients with pattern I MS differ from patients with pattern II or III MS with regard to cerebrospinal fluid (CSF) findings, especially with reference to intrathecal IgG synthesis, which is found in most patients with MS but is frequently missing in MS mimics such as aquaporin-4-IgG-positive neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein-IgG-positive encephalomyelitis...
August 29, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28846375/binding-of-the-microbial-cyclic-tetrapeptide-trapoxin-a-to-the-class-i-histone-deacetylase-hdac8
#19
Nicholas J Porter, David W Christianson
Trapoxin A is a microbial cyclic tetrapeptide that is an essentially irreversible inhibitor of class I histone deacetylases (HDACs). The inhibitory warhead is the α,β-epoxyketone side-chain of (2S,9S)-2-amino-8-oxo-9,10-epoxydecanoic acid (l-Aoe), which mimics the side-chain of the HDAC substrate acetyl-l-lysine. We now report the crystal structure of the HDAC8-trapoxin A complex at 1.24 Å resolution, revealing that the ketone moiety of l-Aoe undergoes nucleophilic attack to form a zinc-bound tetrahedral gem-diolate that mimics the tetrahedral intermediate and its flanking transition states in catalysis...
September 15, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28844746/anthranilate-phosphoribosyltransferase-binding-determinants-for-5-phospho-alpha-d-ribosyl-1-pyrophosphate-prpp-and-the-implications-for-inhibitor-design
#20
Genevieve L Evans, Daniel P Furkert, Nacim Abermil, Preeti Kundu, Katrina M de Lange, Emily J Parker, Margaret A Brimble, Edward N Baker, J Shaun Lott
Phosphoribosyltransferases (PRTs) bind 5'-phospho-α-d-ribosyl-1'-pyrophosphate (PRPP) and transfer its phosphoribosyl group (PRib) to specific nucleophiles. Anthranilate PRT (AnPRT) is a promiscuous PRT that can phosphoribosylate both anthranilate and alternative substrates, and is the only example of a type III PRT. Comparison of the PRPP binding mode in type I, II and III PRTs indicates that AnPRT does not bind PRPP, or nearby metals, in the same conformation as other PRTs. A structure with a stereoisomer of PRPP bound to AnPRT from Mycobacterium tuberculosis (Mtb) suggests a catalytic or post-catalytic state that links PRib movement to metal movement...
August 24, 2017: Biochimica et Biophysica Acta
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