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https://www.readbyqxmd.com/read/29792779/association-of-colistin-resistant-kpc-clonal-strains-with-subsequent-infections-and-colonization-and-biofilm-production
#1
Melina Lorraine Ferreira, Bruna Fuga Araújo, Iara Rossi Gonçalves, Sabrina Royer, Paola Amaral Campos, Luiz Gustavo Machado, Deivid William Fonseca Batistão, Cristiane Silveira Brito, Paulo P Gontijo-Filho, Rosineide Marques Ribas
Carbapenemase-producing organisms are pandemic and a significant threat to public health. We investigated the clonal relatedness of colistin-resistant Klebsiella pneumoniae strains producing KPC-type carbapenemase (KPC-KP) causing subsequent infections or colonization. Moreover, we aimed to gain insight into the ability of biofilm production in K. pneumoniae strains producing carbapenemase. Twenty-two consecutive KPC-KP and one KPC-negative strain was identified from an adult intensive care unit in Brazil. Seventy-five percent of isolates that harbored the blaKPC gene exhibited genetic relatedness by pulsed-field gel electrophoresis, and none presented the plasmid-mediated mcr-1 and blaNDM genes...
May 24, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29790134/-hiv-stigma-and-spiritual-care-in-people-living-with-hiv
#2
Chia-Hui Yu, Yi-Chi Chiu, Su-Fen Cheng, Nai-Ying Ko
HIV infection has been a manageable and chronic illness in Taiwan since the highly active antiretroviral therapy was introduced in 1997. HIV infection is a stigmatized disease due to its perceived association with risky behaviors. HIV often carries a negative image, and people living with HIV(PLWH) face discrimination on multiple fronts. Internalized HIV stigma impacts the spiritual health of people living with HIV in terms of increased levels of shame, self-blame, fear of disclosing HIV status, and isolation and decreased value and connections with God, others, the environment, and the self...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29789190/use-of-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-to-identify-mlst-clade-4-clostridium-difficile-isolates
#3
Jing-Wei Cheng, Chang Liu, Timothy Kudinha, Meng Xiao, Shu-Ying Yu, Chun-Xia Yang, Ming Wei, Guo-Wei Liang, Dong-Hua Shao, Fanrong Kong, Zhao-Hui Tong, Ying-Chun Xu
Clostridium difficile is the leading cause of health care-associated infections. Previous studies suggest that C. difficile MLST clade 4 strains with higher drug resistance rates constitute the major clone spreading in China. Thus development of a rapid and accurate typing method for these strains is needed to monitor the epidemiology of this clone and to guide clinical treatment. A total of 160 non-duplicate C. difficile isolates recovered from three large teaching hospitals in Beijing were studied. All the 41 clade 4 C...
April 26, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29789167/prevalence-of-malnutrition-and-impact-on-clinical-outcomes-in-cancer-services-a-comparison-of-two-time-points
#4
Kathryn M Marshall, Jenelle Loeliger, Linda Nolte, Amber Kelaart, Nicole K Kiss
BACKGROUND: The prevention and management of malnutrition is increasingly recognised as a significant element of cancer care. By identifying and comparing cancer malnutrition in two large cross-sectional cancer populations, this study aims to provide a greater understanding of clinical characteristics and trajectories relating to cancer malnutrition. METHODS: A multi-centre point prevalence study was conducted in Victoria, Australia at two time points (March 2012, May 2014)...
May 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29788036/pediatric-investigators-collaborative-network-on-infections-in-canada-picnic-study-of-respiratory-syncytial-virus-associated-deaths-in-pediatric-patients-in-canada-2003-to-2013
#5
Jennifer Tam, Jesse Papenburg, Sergio Fanella, Sandra Asner, Michelle Barton, Cybele Bergeron, Shalini Desai, Charles Hui, Cheryl Foo, Joanne M Langley, Kirk Leifso, My-Linh Ma, Jeffrey Pernica, Joan Robinson, Roopi Singh, Bruce Tapiero, Upton Allen
Background: Respiratory syncytial virus (RSV) is a major cause of pneumonia and bronchiolitis in children. Mortality rates in previously healthy children hospitalized with RSV are < 0.5%, but up to 37% in patients with underlying medical conditions. The objective of this study was to characterize factors associated with deaths among children hospitalized with RSV infection in Canadian pediatric centres. Methods: Retrospective case series of children 18 years of age or younger with RSV-associated deaths at centres affiliated with the Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) over the period 2003- 2013, inclusive...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29785218/molecular-study-of-quinolone-resistance-determining-regions-of-gyra-gene-and-parc-gene-s-in-clinical-isolates-of-acintobacter-baumannii-resistant-to-fluoroquinolone
#6
Maysaa El Sayed Zaki, Nermen Abou ElKheir, Mohamed Mofreh
Introduction: Acinetobacterb aumannii ( A. baumannii ) is an important pathogen in health care associated infections. Quinolone resistance has emerged in this pathogen. Aims & Objectives: The aim of the present study was to determine the presence of mutations of gyrA gene and parC genes by Restriction Fragment Length Polymorphism Polymerase Chain Reaction (RFLP-PCR) among clinical isolates of A. baumanii . Materials and Methods: The study was carried out on 140 clinical isolates of A...
2018: Open Microbiology Journal
https://www.readbyqxmd.com/read/29784539/revisiting-antithrombin-in-health-and-disease-congenital-deficiencies-and-genetic-variants-and-laboratory-studies-on-%C3%AE-and-%C3%AE-forms
#7
REVIEW
Jean Amiral, Jerard Seghatchian
Antithrombin [AT] is the main inhibitor for activated plasma coagulation serine esterases, inhibiting thrombin, Factors Xa and IXa, but also Factors XIIa, XIa, VIIa, kallicrein, and plasmin. Its activity is highly enhanced by heparin, through binding to the pentasaccharide sequences, for inhibition of all coagulation proteases, except thrombin, which inhibition requires its additional binding to the heparin polysaccharide chain. However, AT is the major inhibitor of thrombin in the blood circulation. Congenital or acquired deficiencies of AT expose affected patients to an increased risk of developing unprovoked and recurrent thrombo-embolic diseases...
April 19, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29784443/exploring-the-why-and-how-questions-associated-with-adoption-of-evidence-based-practices-to-reduce-health-care-associated-infections
#8
Joan N Hebden
No abstract text is available yet for this article.
May 18, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29784441/effect-of-methicillin-resistant-staphylococcus-aureus-in-japan
#9
Hironori Uematsu, Kazuto Yamashita, Seiko Mizuno, Susumu Kunisawa, Keigo Shibayama, Yuichi Imanaka
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is the most common antimicrobial-resistant organism identified in Japanese health care facilities. This study analyzed the clinical and economic burdens attributable to methicillin resistance in S aureus in Japanese hospitals. METHODS: We retrospectively investigated data from 14,905 inpatients of 57 hospitals combined with data from nosocomial infection surveillance and administrative claim databases...
May 18, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29782464/use-of-probiotics-in-the-prevention-of-nosocomial-infections
#10
Ivana Trivić, Iva Hojsak
Nosocomial, hospital-acquired or health care-associated infections occur worldwide, affecting both developed and developing countries. This results in a prolonged hospital stay, increased antimicrobial resistance, increased mortality rate, and significant financial burden on the health care system. Routine preventive measures have led to the decrease in infection spreading; however, it cannot successfully prevent all of them, making a place for the development of new strategies, including probiotics. The aim of this review was to summarize available evidence of the role of probiotics in the prevention of nosocomial infections in children...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29781881/individual-and-network-factors-associated-with-hiv-care-continuum-outcomes-among-nigerian-msm-accessing-healthcare-services
#11
Habib O Ramadhani, Nicaise Ndembi, Rebecca G Nowak, Uchenna Ononaku, Jerry Gwamna, Ifeanyi Orazulike, Sylvia Adebajo, Trevor A Crowell, Hongjie Liu, Stefan D Baral, Julie Ake, Man E Charurat
BACKGROUND: and setting: As data on the determinants of the HIV care continuum from key populations such as men who have sex with men (MSM) in resource-limited, settings (RLS) are limited, the study aimed to characterize HIV care continuum outcomes and assess individual and network barriers to progression through the HIV care continuum among MSM in Abuja and Lagos, Nigeria. METHODS: TRUST/RV368 study used respondent-driven-sampling to accrue MSM into community-based clinics in Nigeria...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781655/mental-health-and-retention-in-hiv-care-a-systematic-review-and-meta-analysis
#12
Cherie R Rooks-Peck, Adebukola H Adegbite, Megan E Wichser, Rebecca Ramshaw, Mary M Mullins, Darrel Higa, Theresa Ann Sipe
OBJECTIVE: Mental health (MH) diagnoses, which are prevalent among persons living with HIV infection, might be linked to failed retention in HIV care. This review synthesized the quantitative evidence regarding associations between MH diagnoses or symptoms and retention in HIV care, as well as determined if MH service utilization (MHSU) is associated with improved retention in HIV care. METHOD: A comprehensive search of the Centers for Disease Control and Prevention's HIV/AIDS Prevention Research Synthesis database of electronic (e...
June 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29781594/-monoclonal-spread-of-multi-drug-resistant-ctx-m-15-producing-klebsiella-pneumoniae-impact-of-measures-to-control-the-outbreak
#13
M A Asencio Egea, M Huertas Vaquero, C Muñoz-Cuevas, J Gaitán Pitera, O Herráez Carrera, P Alcázar Carmona, H D Patiño Ortega, M Franco Huerta, C Román Ortiz, M C Conde García, R Carranza González, J R Barberá, V Bautista Sánchez
OBJECTIVE: To describe an outbreak of multi-drug resistant extended-spectrum β-lactamases-producing Klebsiella pneumoniae (MDR-ESBL-KPN) and the impact of measures for its control. METHODS: We reviewed the patients´ clinical records with MDR-ESBL-KPN isolation during 2013-2016 with resistance to fluoroquinolones, aminoglycosides, fosfomycin, and nitrofurantoin; susceptible to imipenem, meropenem, colistin, and tigecycline and variable to ertapenem and cotrimoxazole (Vitek-2)...
May 18, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29779917/antimicrobial-resistance-among-migrants-in-europe-a-systematic-review-and-meta-analysis
#14
Laura B Nellums, Hayley Thompson, Alison Holmes, Enrique Castro-Sánchez, Jonathan A Otter, Marie Norredam, Jon S Friedland, Sally Hargreaves
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings...
May 17, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29778434/implementation-of-multimodal-infection-control-and-hand-hygiene-strategies-in-acute-care-hospitals-in-greece-a-cross-sectional-benchmarking-survey
#15
Evangelos I Kritsotakis, Eirini Astrinaki, Argyri Messaritaki, Achilleas Gikas
BACKGROUND: In this first attempt to suggest achievable standards for improvement in hospital infection prevention and control (IPC) in Greece, we assessed main IPC structure and process indicators emphasizing hand hygiene. METHODS: Acute-care hospitals across the country participated in a cross-sectional survey by completing the World Health Organization Hand Hygiene Self-assessment Framework (HHSAF) and by providing hospital-level IPC indicators. RESULTS: Seventeen hospitals completed the survey, comprising 14% of the country's public hospitals...
May 16, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29778101/prevalence-of-self-reported-symptoms-of-sexually-transmitted-infections-knowledge-and-sexual-behaviour-among-youth-in-semi-rural-tanzania-in-the-period-of-adolescent-friendly-health-services-strategy-implementation
#16
Ramadhani Abdul, Annette A M Gerritsen, Mary Mwangome, Eveline Geubbels
BACKGROUND: Global evidence shows that sexually transmitted infections (STIs) prevalence and sexual risk behaviours are high among youth, and knowledge about STIs is low. In Tanzania, there is limited recent evidence regarding these issues. The aim of this study was to describe the health seeking behaviour of youth reporting STI symptoms in semi-rural Tanzania and to evaluate the association of socio-demographic characteristics, STI knowledge and sexual risk behaviour with STI symptom reporting...
May 19, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29776778/three-years-post-affordable-care-act-sexually-transmitted-disease-clinics-remain-critical-among-vulnerable-populations
#17
Nicky J Mehtani, Christina M Schumacher, Luke E Johnsen, Adena Greenbaum, C Patrick Chaulk, Khalil G Ghanem, Jacky M Jennings, Kathleen R Page
INTRODUCTION: The purpose of the study is to examine whether demand for publicly funded sexually transmitted disease clinics changed after Affordable Care Act implementation. METHODS: The percentages of total incident sexually transmitted infections in Baltimore City that occurred at publicly funded sexually transmitted disease clinics were compared between the 3 years prior to and following the 2014 Medicaid and private insurance expansions. Risk factors associated with diagnosis at sexually transmitted disease clinics were identified using log binomial regression...
May 15, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29776398/primary-bacterial-ventriculitis-in-adults-an-emergent-diagnosis-challenge-report-of-a-meningoccal-case-and-review-of-the-literature
#18
Anaïs Lesourd, Nicolas Magne, Anaïs Soares, Caroline Lemaitre, Muhamed-Kheir Taha, Isabelle Gueit, Michel Wolff, François Caron
BACKGROUND: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. CASE PRESENTATION: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29776359/evaluation-of-malaria-rapid-diagnostic-test-rdt-use-by-community-health-workers-a-longitudinal-study-in-western-kenya
#19
Matthew R Boyce, Diana Menya, Elizabeth L Turner, Jeremiah Laktabai, Wendy Prudhomme-O'Meara
BACKGROUND: Malaria rapid diagnostic tests (RDTs) are a simple, point-of-care technology that can improve the diagnosis and subsequent treatment of malaria. They are an increasingly common diagnostic tool, but concerns remain about their use by community health workers (CHWs). These concerns regard the long-term trends relating to infection prevention measures, the interpretation of test results and adherence to treatment protocols. This study assessed whether CHWs maintained their competency at conducting RDTs over a 12-month timeframe, and if this competency varied with specific CHW characteristics...
May 18, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29775774/hospital-admissions-2000-2014-a-retrospective-analysis-of-288-096-events-in-patients-with-dementia
#20
Catarina Bernardes, João Massano, Alberto Freitas
INTRODUCTION: Dementia is a leading cause of disability worldwide. It is associated with an increased risk of hospitalization, imposing a significant burden on healthcare systems. The evidence on the long-term evolution of this issue and broadly on healthcare systems is currently limited. This study aims to describe the hospitalizations of people who received a diagnosis of dementia admitted to public general hospitals in a western European country with universal health coverage, over more than a decade...
May 8, 2018: Archives of Gerontology and Geriatrics
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