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https://www.readbyqxmd.com/read/29135727/comparative-cost-analysis-of-single-and-mutli-stage-temporal-deformity-correction-following-neurosurgical-procedures
#1
Anthony Asemota, Gabriel F Santiago, Susan Zhong, Chad R Gordon
PURPOSE: Temporal hollowing deformity (THD) is a visible concavity/convexity in the temporal fossa; a complication often seen following neurosurgical/craniofacial procedures. Although numerous techniques have been described, no study to date has shown the healthcare costs associated with temporal hollowing correction surgery. Thus, the purpose here is to compare and contrast the direct costs related to temporal cranioplasty using various methods including: liquid poly-methyl-methacrylate (PMMA) implants with screw fixation, prebent, modified titanium mesh implants, and customized cranial implants (CCIs) with dual-purpose design...
November 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29075340/vascular-endothelial-growth-receptor-1-acts-as-a-stress-associated-protein-in-the-therapeutic-response-to-thalidomide
#2
Qin Liu, Tao Yin, Guoping Wang, Fuchun Guo, Yuhong Ou, Yi Li, Yongsheng Wang
Thalidomide (THD) exhibits antitumor effects in several types of cancer. However, the failure of THD to inhibit tumor growth has also been observed in a number of murine models in vivo. The mechanism involved in the therapeutic failure of THD remains unclear. The present study demonstrated that, accompanied by growth-arresting and apoptosis-inducing effects (P<0.05), THD upregulated vascular endothelial growth factor receptor 1 (VEGFR1) expression levels in CT26 murine colorectal carcinoma cell lines. This in vitro phenomenon was also observed in various other cell lines, including human umbilical vein endothelial cells, SW480, SW620 and HCT116...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29055294/nucleation-and-growth-of-copper-selective-area-atomic-layer-deposition-on-palladium-nanostructures
#3
J Qi, D T Zimmerman, G J Weisel, B G Willis
The nucleation and growth of copper atomic layer deposition (ALD) on palladium have been investigated for applications in nanoscale devices. Palladium nanostructures were fabricated by electron beam lithography and range in size from 250 nm to 5 μm, prepared on oxidized silicon wafers. Copper ALD using Cu(thd)2(s) and H2(g) as reactants was carried out to selectively deposit copper on palladium seeded regions to the exclusion of surrounding oxide surfaces. Nuclei sizes and densities have been quantified by scanning electron microscopy for different growth conditions...
October 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28942193/identification-of-novel-nrf2-activators-from-cinnamomum-chartophyllum-h-w-li-and-their-potential-application-of-preventing-oxidative-insults-in-human-lung-epithelial-cells
#4
Ming-Xing Zhou, Guo-Hui Li, Bin Sun, You-Wei Xu, Ai-Ling Li, Yan-Ru Li, Dong-Mei Ren, Xiao-Ning Wang, Xue-Sen Wen, Hong-Xiang Lou, Tao Shen
Human lung tissue, directly exposed to the environmental oxidants and toxicants, is apt to be harmed to bring about acute or chronic oxidative insults. The nuclear factor erythroid 2-related factor 2 (Nrf2) represents a central cellular defense mechanism, and is a target for developing agents against oxidative insult-induced human lung diseases. Our previous study found that the EtOH extract of Cinnamomum chartophyllum protected human bronchial epithelial cells against oxidative insults via Nrf2 activation...
September 14, 2017: Redox Biology
https://www.readbyqxmd.com/read/28932913/a-prospective-randomized-controlled-trial-evaluating-the-short-term-outcomes-of-transanal-hemorrhoidal-dearterialization-versus-tissue-selecting-technique
#5
A L H Leung, T P P Cheung, K Tung, Y P Tsang, H Cheung, C W Lau, C N Tang
BACKGROUND: Tissue-selecting technique (TST) is a novel stapled hemorrhoidectomy technique which targets the hemorrhoids, leaving uninvolved mucosal bridges intact and avoiding circumferential circular stapling. The aim of this study was to compare the short-term outcomes of TST and transanal hemorrhoidal dearterialization (THD). METHODS: Patients presenting with symptomatic hemorrhoids were recruited. Patients were randomized into two groups: (1) TST and (2) THD...
September 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28854065/efficacy-of-thalidomide-in-preventing-delayed-nausea-and-vomiting-induced-by-highly-emetogenic-chemotherapy-a-randomized-multicenter-double-blind-placebo-controlled-phase-iii-trial-clog1302-study
#6
RANDOMIZED CONTROLLED TRIAL
Lingyun Zhang, Xiujuan Qu, Yuee Teng, Jing Shi, Ping Yu, Tao Sun, Jingyan Wang, Zhitu Zhu, Xiuna Zhang, Mingfang Zhao, Jing Liu, Bo Jin, Ying Luo, Zan Teng, Yuyang Dong, Fugang Wen, Yuzhi An, Caijun Yuan, Tiejun Chen, Lizhong Zhou, Ying Chen, Jian Zhang, Zhenghua Wang, Jinglei Qu, Feng Jin, Jingdong Zhang, Xiuhua Jin, Xiaodong Xie, Jun Wang, Li Man, Lingyu Fu, Yunpeng Liu
Purpose We examined the efficacy and safety of thalidomide (THD) for the prevention of delayed nausea and vomiting in patients who received highly emetogenic chemotherapy (HEC). Patients and Methods In a randomized, double-blind, active-controlled, phase III trial, chemotherapy-naive patients with cancer who were scheduled to receive HEC that contained cisplatin or cyclophosphamide-doxorubicin/epirubincin ≥ 50 mg/m(2) regimens were randomly assigned to a THD group (100 mg twice daily on days 1 to 5) or placebo group, both with palonosetron (0...
November 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28836109/irmpd-action-spectroscopy-er-cid-experiments-and-theoretical-studies-of-sodium-cationized-thymidine-and-5-methyluridine-kinetic-trapping-during-the-esi-desolvation-process-preserves-the-solution-structure-of-thd-na
#7
Y Zhu, H A Roy, N A Cunningham, S F Strobehn, J Gao, M U Munshi, G Berden, J Oomens, M T Rodgers
Thymidine (dThd) is a fundamental building block of DNA nucleic acids, whereas 5-methyluridine (Thd) is a common modified nucleoside found in tRNA. In order to determine the conformations of the sodium cationized thymine nucleosides [dThd+Na](+) and [Thd+Na](+) produced by electrospray ionization, their infrared multiple photon dissociation (IRMPD) action spectra are measured. Complementary electronic structure calculations are performed to determine the stable low-energy conformations of these complexes. Geometry optimizations and frequency analyses are performed at the B3LYP/6-311+G(d,p) level of theory, whereas energies are calculated at the B3LYP/6-311+G(2d,2p) level of theory...
November 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28794872/thd-and-mucopexy-efficacy-and-controversy
#8
Haytham Abudeeb, Ajogwu Ugwu, Jamshid Darabnia, Ahmed Hammad, Khurram Khan, Min Maung, Elizabeth McNulty, Abdul Latif Khan, Arijit Mukherjee
AIMS: Transanal haemorrhoidal dearterialisation and mucopexy has evolved in recent years as a popular minimally invasive non-excisional surgery for symptomatic prolapsing haemorrhoids. The long-term outcome of this procedure however, remains to be established. We aim to analyse the long-term outcome of THD-mucopexy in the management of prolapsing haemorrhoids based on the evidence of a prospective data from a single institution. METHODS: A prospective data was collected on 100 consecutive cases of grade 3 and 4 symptomatic haemorrhoids between the period 03/2010 and 06/2015 who underwent the procedure as a day case under general anaesthetic...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28782949/on-the-density-functional-theory-treatment-of-lanthanide-coordination-compounds-a-comparative-study-in-a-series-of-cu-ln-ln-gd-tb-lu-binuclear-complexes
#9
Marilena Ferbinteanu, Alessandro Stroppa, Marco Scarrozza, Ionel Humelnicu, Dan Maftei, Bogdan Frecus, Fanica Cimpoesu
The nontrivial aspects of electron structure in lanthanide complexes, considering ligand field (LF) and exchange coupling effects, have been investigated by means of density functional theory (DFT) calculations, taking as a prototypic case study a series of binuclear complexes [LCu(O2COMe)Ln(thd)2], where L(2-) = N,N'-2,2-dimethyl-propylene-di(3-methoxy-salicylidene-iminato) and Ln = Tb, Lu, and Gd. Particular attention has been devoted to the Cu-Tb complex, which shows a quasi-degenerate nonrelativistic ground state...
August 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28747780/novel-strategies-to-mimic-transmembrane-tumor-necrosis-factor-dependent-activation-of-tumor-necrosis-factor-receptor-2
#10
Roman Fischer, Jessica Marsal, Cristiano Guttà, Stephan A Eisler, Nathalie Peters, John R Bethea, Klaus Pfizenmaier, Roland E Kontermann
Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and composition of tmTNF during TNFR2 activation, we constructed differently oligomerized single chain TNF ligands (scTNF) comprised of three TNF homology domain (THD) protomers that mimic tmTNF. Using a variety of cellular and in vivo assays, we can show that higher oligomerization of the scTNF trimers results in more efficient TNF/TNFR2 clustering and subsequent signal transduction...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747043/hydrothermal-synthesis-of-in2o3-nanoparticles-hybrid-twins-hexagonal-disk-zno-heterostructures-for-enhanced-photocatalytic-activities-and-stability
#11
Hairui Liu, Haifa Zhai, Chunjie Hu, Jien Yang, Zhiyong Liu
In2O3 nanoparticles hybrid twins hexagonal disk (THD) ZnO with different ratios were fabricated by a hydrothermal method. The as-obtained ZnO/In2O3 composites are constituted by hexagonal disks ZnO with diameters of about 1 μm and In2O3 nanoparticles with sizes of about 20-50 nm. With the increase of In2O3 content in ZnO/In2O3 composites, the absorption band edges of samples shifted from UV to visible light region. Compared with pure ZnO, the ZnO/In2O3 composites show enhanced photocatalytic activities for degradation of methyl orange (MO) and 4-nitrophenol (4-NP) under solar light irradiation...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28671580/design-and-parametric-study-of-the-magnetic-sensor-for-position-detection-in-linear-motor-based-on-nonlinear-parametric-model-order-reduction
#12
Sarbajit Paul, Junghwan Chang
This paper presents a design approach for a magnetic sensor module to detect mover position using the proper orthogonal decomposition-dynamic mode decomposition (POD-DMD)-based nonlinear parametric model order reduction (PMOR). The parameterization of the sensor module is achieved by using the multipolar moment matching method. Several geometric variables of the sensor module are considered while developing the parametric study. The operation of the sensor module is based on the principle of the airgap flux density distribution detection by the Hall Effect IC...
July 1, 2017: Sensors
https://www.readbyqxmd.com/read/28663765/minimally-invasive-thalamic-hematoma-drainage-can-improve-the-six-month-outcome-of-thalamic-hemorrhage
#13
Wen-Ming Liu, Xue-Guang Zhang, Ze-Li Zhang, Gang Li, Qi-Bing Huang
OBJECTIVE: To explore predictors of the 6-month clinical outcome of thalamic hemorrhage, and evaluate if minimally invasive thalamic hematoma drainage (THD) could improve its prognosis. METHODS: A total of 54 patients with spontaneous thalamic hemorrhage were evaluated retrospectively. Clinical data, including demographics, stroke risk factors, neuroimaging variables, Glasgow Coma Score (GCS) on admission, surgical strategy, and outcome, were collected. Clinical outcome was assessed using a modified Rankin Scale, six months after onset...
April 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28657451/cost-effectiveness-of-dedicated-dietitians-for-hyperphosphatemia-management-among-hemodialysis-patients-in-lebanon-results-from-the-nutrition-education-for-management-of-osteodystrophy-trial
#14
Rana Rizk, Mickaël Hiligsmann, Mirey Karavetian, Silvia M A A Evers
AIM: To assess the cost-effectiveness of nutrition education by dedicated dietitians (DD) for hyperphosphatemia management among hemodialysis patients. MATERIALS AND METHODS: This was a trial-based economic evaluation in 12 Lebanese hospital-based units. In total, 545 prevalent patients were cluster randomized to DD, trained hospital dietitian (THD), and existing practice (EP) groups. During Phase I (6 months), DD (n = 116) received intensive education by DD trained on renal nutrition, THD (n = 299) received care from trained hospital dietitians, and EP (n = 130) received usual care from untrained hospital dietitians...
July 13, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28655781/the-hepatocyte-specific-hnf4%C3%AE-mir-122-pathway-contributes-to-iron-overload-mediated-hepatic-inflammation
#15
Min Li, Yuxiao Tang, Lusha Wu, Fengfeng Mo, Xin Wang, Hongxia Li, Ruirui Qi, Hongwei Zhang, Arun Srivastava, Chen Ling
Hepatic iron overload (IO) is a major complication of transfusional therapy. It was generally thought that IO triggers substantial inflammatory responses by producing reactive oxygen species in hepatic macrophages. Recently, a decrease in microRNA-122 (miR-122) expression was observed in a genetic knockout (Hfe(-/-)) mouse model of IO. Because hepatocyte-enriched miR-122 is a key regulator of multiple hepatic pathways, including inflammation, it is of interest whether hepatocyte directly contributes to IO-mediated hepatic inflammation...
August 24, 2017: Blood
https://www.readbyqxmd.com/read/28613074/blue-to-green-emitting-neutral-ir-iii-complexes-bearing-pentafluorosulfanyl-groups-a-combined-experimental-and-theoretical-study
#16
Amlan K Pal, Adam F Henwood, David B Cordes, Alexandra M Z Slawin, Ifor D W Samuel, Eli Zysman-Colman
A structure-property relationship study of neutral heteroleptic (1 and 2, [Ir(C(∧)N)2(L(∧)X)]) and homoleptic (3 and 4, fac-[Ir(C(∧)N)3]) Ir(III) complexes (where L(∧)X = anionic 2,2,6,6-tetramethylheptane-3,5-dionato-κO(3),κO(6) (thd) and C(∧)N = a cyclometalating ligand bearing a pentafluorosulfanyl (-SF5) electron-withdrawing group (EWG) at the C4 (HL1) and C3 (HL2) positions of the phenyl moiety) is presented. These complexes have been fully structurally characterized, including by single-crystal X-ray diffraction, and their electrochemical and optical properties have also been extensively studied...
July 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28610451/cognitive-function-is-largely-intact-in-methadone-maintenance-treatment-patients
#17
Odelia Elkana, Miriam Adelson, Glen M Doniger, Anat Sason, Einat Peles
OBJECTIVES: To confirm our previous findings of less cognitive impairments (based on cognitive screening tools) among methadone maintenance treatment (MMT) patients who achieved take-home dose (THD) privileges. METHODS: a random sample of 65 Israeli MMT patients were studied using computerised, age and education standardised, cognitive domains (attention, executive function, memory, motor skills), and non-computerised phonetic and semantic verbal fluency. RESULTS: Cognitive scores were within ±1 standard deviation (SD) of average for most domains, including non-verbal IQ, attention and motor skills...
July 5, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28582895/implementation-of-integrated-circuit-and-design-of-sar-adc-for-fully-implantable-hearing-aids
#18
Jong Hoon Kim, Jyung Hyun Lee, Jin-Ho Cho
BACKGOUND: The hearing impaired population has been increasing; many people suffer from hearing problems. To deal with this difficulty, various types of hearing aids are being rapidly developed. In particular, fully implantable hearing aids are being actively studied to improve the performance of existing hearing aids and to reduce the stigma of hearing loss patients. It has to be of small size and low-power consumption for easy implantation and long-term use. OBJECTIVE: The objective of the study was to implement a small size and low-power consumption successive approximation register analog-to-digital converter (SAR ADC) for fully implantable hearing aids...
July 20, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28451767/distal-doppler-guided-transanal-hemorrhoidal-dearterialization-with-mucopexy-versus-conventional-hemorrhoidectomy-for-grade-iii-and-iv-hemorrhoids-postoperative-morbidity-and-long-term-outcomes
#19
L Trenti, S Biondo, A Galvez, A Bravo, J Cabrera, E Kreisler
BACKGROUND: Distal Doppler-guided transanal hemorrhoidal dearterialization with mucopexy (Doppler-guided THD) seems to be associated with better short-term outcomes than conventional hemorrhoidectomy, but there are little data about long-term recurrence. The aim of this study was to compare Doppler-guided THD for grade III-IV hemorrhoids with conventional hemorrhoidectomy with regard to long-term postoperative morbidity and recurrence. METHODS: This was a single-center longitudinal and comparative study of a cohort of patients who underwent either distal Doppler-guided THD with low ligation of the hemorrhoidal artery and mucopexy or conventional excisional hemorrhoidectomy (Milligan and Morgan or Ferguson) for grade III and IV hemorrhoids...
May 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28426283/identification-of-the-proteome-complement-of-humantlk1-reveals-it-binds-and-phosphorylates-nek1-regulating-its-activity
#20
Vibha Singh, Zachary M Connelly, Xinggui Shen, Arrigo De Benedetti
The Tousled Like kinases (TLKs) are involved in numerous cellular functions, including the DNA Damage Response (DDR), but only a handful of substrates have been identified thus far. Through a novel proteomic screen, we have now identified 165 human proteins interacting with TLK1, and we have focused this work on NEK1 because of its known role in the DDR, upstream of ATR and Chk1. TLK1 and NEK1 were found to interact by coIP, and their binding is strengthened following exposure of cells to H2O2. Following incubation with doxorubicin, TLK1 and NEK1 relocalize with nuclear repair foci along with γH2AX...
May 19, 2017: Cell Cycle
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