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https://www.readbyqxmd.com/read/29299971/the-role-of-the-fas-fasl-signaling-pathway-in-environmental-toxicant-induced-testicular-cell-apoptosis-an-update
#1
Mei Wang, Ping Su
The Fas/FasL signaling pathway is one of the major pathways that regulate apoptosis. Increasing studies have shown that the activation of the Fas/FasL signaling pathway is closely associated with testicular cell apoptosis. However, the mechanism involved is still unclear. We discuss recent findings regarding the molecular mechanisms by which environmental toxicants induce testicular pathology via Fas/FasL signaling. These findings suggest that Fas/FasL signaling is employed to impact the sensitivity (a response to external factors) of germ cells, disrupt steroidogenic hormone and cytokine metabolism mediated by Sertoli cells, and elicit the activation of NFAT (nuclear factor of activated T-cells) in Leydig cell apoptosis...
January 4, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29242193/crystal-structure-of-murine-4-1bb-and-its-interaction-with-4-1bbl-support-a-role-for-galectin-9-in-4-1bb-signaling
#2
Aruna Bitra, Tzanko Doukov, Jing Wang, Gaelle Picarda, Chris A Benedict, Michael Croft, Dirk M Zajonc
4-1BB (CD137) is a TNF receptor superfamily (TNFRSF) member that is thought to undergo receptor trimerization upon binding to its trimeric TNF superfamily ligand (4-1BBL) to stimulate immune responses. 4-1BB also can bind to the tandem repeat-type lectin Galectin-9 (Gal-9), and signaling through mouse (m)4-1BB is reduced in Galectin-9 (Gal-9) deficient mice, suggesting a pivotal role of Gal-9 in m4-1BB activation. Here, using sulfur-SAD phasing, we determined the crystal structure of m4-1BB to 2.2 Å resolution...
December 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29214383/evaluation-of-the-effectiveness-and-patients-contentment-with-transanal-haemorrhoidal-artery-dearterialisation-and-mucopexy-thd-for-treatment-of-haemorrhoidal-disease-a-6-year-study
#3
Qurat Ul Ain, Yasir Bashir, Emmanuel Eguare
INTRODUCTION: With high incidence of haemorrhoidal disease and significant complication rates of traditional haemorrhoidectomy procedures, transanal haemorrhoidal artery ligation and mucopexy (THD) emerges as a minimally invasive procedure with superior results. However, it is crucial that effectiveness of results and patient satisfaction be gauged based on post-operative experience, symptomology and recurrence. AIM: Our aim is to provide a long-term analysis of efficacy and patient's satisfaction for the procedure, for the largest patient population, in correlation to presenting symptoms and degree of haemorrhoids...
December 6, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29214174/feasibility-of-round-window-stimulation-by-a-novel-electromagnetic-microactuator
#4
Wouter Johannes van Drunen, Mathias Mueller, Anatoly Glukhovskoy, Rolf Salcher, Marc Christopher Wurz, Thomas Lenarz, Hannes Maier
Introduction: Most implantable hearing aids currently available were developed to compensate the sensorineural hearing loss by driving middle ear structures (e.g., the ossicles). These devices are successfully used in round window (RW) stimulation clinically, although this was initially not the intended use. Here, a novel microactuator, specifically designed for RW stimulation, was tested in human temporal bones to determine actuator performance and applicability. Methods: Stapes footplate response to RW stimulation was determined experimentally in human temporal bones and the obtained sound pressure output level was estimated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29182899/five-year-experience-of-the-treatment-of-squamous-cell-carcinoma-of-the-anus
#5
C A Leo, C Santorelli, J D Hodgkinson, O Bidovaneta, F Baldelli, F Cantarella, E Cavazzoni
OBJECTIVES: The best treatment of early stage anal squamous cell carcinoma (SCC) is under debated. Wide local excision (WLE) may be considered adequate for stage 1 anal margin cancer. This study demonstrates our experience in treatment of patients with SCC over 5 years. PATIENTS AND METHODS: We conducted a retrospective study of patients who had undergone anal screening or anal cancer surveillance between October 2010 and 2015 in our department. Each patient underwent anal Pap test, HPV test PCR HPV DNA and cytology by Thin Prep...
July 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29182436/vertical-and-horizontal-jump-capacity-in-international-cerebral-palsy-football-players
#6
Raul Reina, Aitor Iturricastillo, Rafael Sabido, Maria Campayo-Piernas, Javier Yanci
PURPOSE: the aims of the present study were to evaluate the reliability and validity of vertical and horizontal jump tests in football players with cerebral palsy (FPCP), and to analyze the jump performance differences between current IFCPF functional classes (i.e. FT5-FT8). METHODS: One hundred and thirty-two international para-footballers (25.8 ± 6.7 years; 70.0 ± 9.1 kg; 175.7 ± 7.3 cm; 22.8 ± 2.8 kg·m-2; 10.7 ± 7.5 years training experience) participated in the study...
November 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29170839/transanal-hemorrhoidal-dearterialization-thd-for-hemorrhoidal-disease-a-single-center-study-on-1000-consecutive-cases-and-a-review-of-the-literature
#7
Carlo Ratto, Paola Campennì, Francesco Papeo, Lorenza Donisi, Francesco Litta, Angelo Parello
BACKGROUND: The transanal hemorrhoidal dearterialization (THD) Doppler procedure is a minimally invasive technique to treat symptomatic hemorrhoids. The aim of the study was to assess the clinical efficacy and the satisfaction of patients in a large series treated with THD and to review the relevant literature. METHODS: In this retrospective, single-institution, study consecutive patients with grade 2, 3, or 4 hemorrhoidal disease were treated with the THD Doppler procedure...
December 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29153539/deviations-in-frequency-and-mode-of-vibration-in-whole-body-vibration-training-devices-with-long-term-and-regular-use
#8
Tobias S Kaeding, Sanam Moghaddamnia, Momme Kück, Lothar Stein
Research regarding whole body vibration training (WBVT) and its practical use may be hindered by the fact that WBVT devices generate frequencies and/or modes of vibration different from their preset adjustments. This research aimed to clarify whether prolonged regular use can generate such deviations in frequency and mode of vibration. Three WBVT devices, each used for approximately 13 months in two research projects, were tested with an accelerometer before start of the 1st study, after four months, and after 13 months (the completion of the 2nd study)...
November 16, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29135727/comparative-cost-analysis-of-single-and-mutli-stage-temporal-deformity-correction-following-neurosurgical-procedures
#9
Anthony Asemota, Gabriel F Santiago, Susan Zhong, Chad R Gordon
PURPOSE: Temporal hollowing deformity (THD) is a visible concavity/convexity in the temporal fossa; a complication often seen following neurosurgical/craniofacial procedures. Although numerous techniques have been described, no study to date has shown the healthcare costs associated with temporal hollowing correction surgery. Thus, the purpose here is to compare and contrast the direct costs related to temporal cranioplasty using various methods including: liquid poly-methyl-methacrylate (PMMA) implants with screw fixation, prebent, modified titanium mesh implants, and customized cranial implants (CCIs) with dual-purpose design...
November 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29075340/vascular-endothelial-growth-receptor-1-acts-as-a-stress-associated-protein-in-the-therapeutic-response-to-thalidomide
#10
Qin Liu, Tao Yin, Guoping Wang, Fuchun Guo, Yuhong Ou, Yi Li, Yongsheng Wang
Thalidomide (THD) exhibits antitumor effects in several types of cancer. However, the failure of THD to inhibit tumor growth has also been observed in a number of murine models in vivo. The mechanism involved in the therapeutic failure of THD remains unclear. The present study demonstrated that, accompanied by growth-arresting and apoptosis-inducing effects (P<0.05), THD upregulated vascular endothelial growth factor receptor 1 (VEGFR1) expression levels in CT26 murine colorectal carcinoma cell lines. This in vitro phenomenon was also observed in various other cell lines, including human umbilical vein endothelial cells, SW480, SW620 and HCT116...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29055294/nucleation-and-growth-of-copper-selective-area-atomic-layer-deposition-on-palladium-nanostructures
#11
J Qi, D T Zimmerman, G J Weisel, B G Willis
The nucleation and growth of copper atomic layer deposition (ALD) on palladium have been investigated for applications in nanoscale devices. Palladium nanostructures were fabricated by electron beam lithography and range in size from 250 nm to 5 μm, prepared on oxidized silicon wafers. Copper ALD using Cu(thd)2(s) and H2(g) as reactants was carried out to selectively deposit copper on palladium seeded regions to the exclusion of surrounding oxide surfaces. Nuclei sizes and densities have been quantified by scanning electron microscopy for different growth conditions...
October 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28942193/identification-of-novel-nrf2-activators-from-cinnamomum-chartophyllum-h-w-li-and-their-potential-application-of-preventing-oxidative-insults-in-human-lung-epithelial-cells
#12
Ming-Xing Zhou, Guo-Hui Li, Bin Sun, You-Wei Xu, Ai-Ling Li, Yan-Ru Li, Dong-Mei Ren, Xiao-Ning Wang, Xue-Sen Wen, Hong-Xiang Lou, Tao Shen
Human lung tissue, directly exposed to the environmental oxidants and toxicants, is apt to be harmed to bring about acute or chronic oxidative insults. The nuclear factor erythroid 2-related factor 2 (Nrf2) represents a central cellular defense mechanism, and is a target for developing agents against oxidative insult-induced human lung diseases. Our previous study found that the EtOH extract of Cinnamomum chartophyllum protected human bronchial epithelial cells against oxidative insults via Nrf2 activation...
September 14, 2017: Redox Biology
https://www.readbyqxmd.com/read/28932913/a-prospective-randomized-controlled-trial-evaluating-the-short-term-outcomes-of-transanal-hemorrhoidal-dearterialization-versus-tissue-selecting-technique
#13
A L H Leung, T P P Cheung, K Tung, Y P Tsang, H Cheung, C W Lau, C N Tang
BACKGROUND: Tissue-selecting technique (TST) is a novel stapled hemorrhoidectomy technique which targets the hemorrhoids, leaving uninvolved mucosal bridges intact and avoiding circumferential circular stapling. The aim of this study was to compare the short-term outcomes of TST and transanal hemorrhoidal dearterialization (THD). METHODS: Patients presenting with symptomatic hemorrhoids were recruited. Patients were randomized into two groups: (1) TST and (2) THD...
September 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28854065/efficacy-of-thalidomide-in-preventing-delayed-nausea-and-vomiting-induced-by-highly-emetogenic-chemotherapy-a-randomized-multicenter-double-blind-placebo-controlled-phase-iii-trial-clog1302-study
#14
RANDOMIZED CONTROLLED TRIAL
Lingyun Zhang, Xiujuan Qu, Yuee Teng, Jing Shi, Ping Yu, Tao Sun, Jingyan Wang, Zhitu Zhu, Xiuna Zhang, Mingfang Zhao, Jing Liu, Bo Jin, Ying Luo, Zan Teng, Yuyang Dong, Fugang Wen, Yuzhi An, Caijun Yuan, Tiejun Chen, Lizhong Zhou, Ying Chen, Jian Zhang, Zhenghua Wang, Jinglei Qu, Feng Jin, Jingdong Zhang, Xiuhua Jin, Xiaodong Xie, Jun Wang, Li Man, Lingyu Fu, Yunpeng Liu
Purpose We examined the efficacy and safety of thalidomide (THD) for the prevention of delayed nausea and vomiting in patients who received highly emetogenic chemotherapy (HEC). Patients and Methods In a randomized, double-blind, active-controlled, phase III trial, chemotherapy-naive patients with cancer who were scheduled to receive HEC that contained cisplatin or cyclophosphamide-doxorubicin/epirubincin ≥ 50 mg/m2 regimens were randomly assigned to a THD group (100 mg twice daily on days 1 to 5) or placebo group, both with palonosetron (0...
November 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28836109/irmpd-action-spectroscopy-er-cid-experiments-and-theoretical-studies-of-sodium-cationized-thymidine-and-5-methyluridine-kinetic-trapping-during-the-esi-desolvation-process-preserves-the-solution-structure-of-thd-na
#15
Y Zhu, H A Roy, N A Cunningham, S F Strobehn, J Gao, M U Munshi, G Berden, J Oomens, M T Rodgers
Thymidine (dThd) is a fundamental building block of DNA nucleic acids, whereas 5-methyluridine (Thd) is a common modified nucleoside found in tRNA. In order to determine the conformations of the sodium cationized thymine nucleosides [dThd+Na](+) and [Thd+Na](+) produced by electrospray ionization, their infrared multiple photon dissociation (IRMPD) action spectra are measured. Complementary electronic structure calculations are performed to determine the stable low-energy conformations of these complexes. Geometry optimizations and frequency analyses are performed at the B3LYP/6-311+G(d,p) level of theory, whereas energies are calculated at the B3LYP/6-311+G(2d,2p) level of theory...
November 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28794872/thd-and-mucopexy-efficacy-and-controversy
#16
Haytham Abudeeb, Ajogwu Ugwu, Jamshid Darabnia, Ahmed Hammad, Khurram Khan, Min Maung, Elizabeth McNulty, Abdul Latif Khan, Arijit Mukherjee
AIMS: Transanal haemorrhoidal dearterialisation and mucopexy has evolved in recent years as a popular minimally invasive non-excisional surgery for symptomatic prolapsing haemorrhoids. The long-term outcome of this procedure however, remains to be established. We aim to analyse the long-term outcome of THD-mucopexy in the management of prolapsing haemorrhoids based on the evidence of a prospective data from a single institution. METHODS: A prospective data was collected on 100 consecutive cases of grade 3 and 4 symptomatic haemorrhoids between the period 03/2010 and 06/2015 who underwent the procedure as a day case under general anaesthetic...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28782949/on-the-density-functional-theory-treatment-of-lanthanide-coordination-compounds-a-comparative-study-in-a-series-of-cu-ln-ln-gd-tb-lu-binuclear-complexes
#17
Marilena Ferbinteanu, Alessandro Stroppa, Marco Scarrozza, Ionel Humelnicu, Dan Maftei, Bogdan Frecus, Fanica Cimpoesu
The nontrivial aspects of electron structure in lanthanide complexes, considering ligand field (LF) and exchange coupling effects, have been investigated by means of density functional theory (DFT) calculations, taking as a prototypic case study a series of binuclear complexes [LCu(O2COMe)Ln(thd)2], where L(2-) = N,N'-2,2-dimethyl-propylene-di(3-methoxy-salicylidene-iminato) and Ln = Tb, Lu, and Gd. Particular attention has been devoted to the Cu-Tb complex, which shows a quasi-degenerate nonrelativistic ground state...
August 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28747780/novel-strategies-to-mimic-transmembrane-tumor-necrosis-factor-dependent-activation-of-tumor-necrosis-factor-receptor-2
#18
Roman Fischer, Jessica Marsal, Cristiano Guttà, Stephan A Eisler, Nathalie Peters, John R Bethea, Klaus Pfizenmaier, Roland E Kontermann
Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and composition of tmTNF during TNFR2 activation, we constructed differently oligomerized single chain TNF ligands (scTNF) comprised of three TNF homology domain (THD) protomers that mimic tmTNF. Using a variety of cellular and in vivo assays, we can show that higher oligomerization of the scTNF trimers results in more efficient TNF/TNFR2 clustering and subsequent signal transduction...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747043/hydrothermal-synthesis-of-in2o3-nanoparticles-hybrid-twins-hexagonal-disk-zno-heterostructures-for-enhanced-photocatalytic-activities-and-stability
#19
Hairui Liu, Haifa Zhai, Chunjie Hu, Jien Yang, Zhiyong Liu
In2O3 nanoparticles hybrid twins hexagonal disk (THD) ZnO with different ratios were fabricated by a hydrothermal method. The as-obtained ZnO/In2O3 composites are constituted by hexagonal disks ZnO with diameters of about 1 μm and In2O3 nanoparticles with sizes of about 20-50 nm. With the increase of In2O3 content in ZnO/In2O3 composites, the absorption band edges of samples shifted from UV to visible light region. Compared with pure ZnO, the ZnO/In2O3 composites show enhanced photocatalytic activities for degradation of methyl orange (MO) and 4-nitrophenol (4-NP) under solar light irradiation...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28671580/design-and-parametric-study-of-the-magnetic-sensor-for-position-detection-in-linear-motor-based-on-nonlinear-parametric-model-order-reduction
#20
Sarbajit Paul, Junghwan Chang
This paper presents a design approach for a magnetic sensor module to detect mover position using the proper orthogonal decomposition-dynamic mode decomposition (POD-DMD)-based nonlinear parametric model order reduction (PMOR). The parameterization of the sensor module is achieved by using the multipolar moment matching method. Several geometric variables of the sensor module are considered while developing the parametric study. The operation of the sensor module is based on the principle of the airgap flux density distribution detection by the Hall Effect IC...
July 1, 2017: Sensors
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