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https://www.readbyqxmd.com/read/28747780/novel-strategies-to-mimic-transmembrane-tumor-necrosis-factor-dependent-activation-of-tumor-necrosis-factor-receptor-2
#1
Roman Fischer, Jessica Marsal, Cristiano Guttà, Stephan A Eisler, Nathalie Peters, John R Bethea, Klaus Pfizenmaier, Roland E Kontermann
Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and composition of tmTNF during TNFR2 activation, we constructed differently oligomerized single chain TNF ligands (scTNF) comprised of three TNF homology domain (THD) protomers that mimic tmTNF. Using a variety of cellular and in vivo assays, we can show that higher oligomerization of the scTNF trimers results in more efficient TNF/TNFR2 clustering and subsequent signal transduction...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747043/hydrothermal-synthesis-of-in2o3-nanoparticles-hybrid-twins-hexagonal-disk-zno-heterostructures-for-enhanced-photocatalytic-activities-and-stability
#2
Hairui Liu, Haifa Zhai, Chunjie Hu, Jien Yang, Zhiyong Liu
In2O3 nanoparticles hybrid twins hexagonal disk (THD) ZnO with different ratios were fabricated by a hydrothermal method. The as-obtained ZnO/In2O3 composites are constituted by hexagonal disks ZnO with diameters of about 1 μm and In2O3 nanoparticles with sizes of about 20-50 nm. With the increase of In2O3 content in ZnO/In2O3 composites, the absorption band edges of samples shifted from UV to visible light region. Compared with pure ZnO, the ZnO/In2O3 composites show enhanced photocatalytic activities for degradation of methyl orange (MO) and 4-nitrophenol (4-NP) under solar light irradiation...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28671580/design-and-parametric-study-of-the-magnetic-sensor-for-position-detection-in-linear-motor-based-on-nonlinear-parametric-model-order-reduction
#3
Sarbajit Paul, Junghwan Chang
This paper presents a design approach for a magnetic sensor module to detect mover position using the proper orthogonal decomposition-dynamic mode decomposition (POD-DMD)-based nonlinear parametric model order reduction (PMOR). The parameterization of the sensor module is achieved by using the multipolar moment matching method. Several geometric variables of the sensor module are considered while developing the parametric study. The operation of the sensor module is based on the principle of the airgap flux density distribution detection by the Hall Effect IC...
July 1, 2017: Sensors
https://www.readbyqxmd.com/read/28663765/minimally-invasive-thalamic-hematoma-drainage-can-improve-the-six-month-outcome-of-thalamic-hemorrhage
#4
Wen-Ming Liu, Xue-Guang Zhang, Ze-Li Zhang, Gang Li, Qi-Bing Huang
OBJECTIVE: To explore predictors of the 6-month clinical outcome of thalamic hemorrhage, and evaluate if minimally invasive thalamic hematoma drainage (THD) could improve its prognosis. METHODS: A total of 54 patients with spontaneous thalamic hemorrhage were evaluated retrospectively. Clinical data, including demographics, stroke risk factors, neuroimaging variables, Glasgow Coma Score (GCS) on admission, surgical strategy, and outcome, were collected. Clinical outcome was assessed using a modified Rankin Scale, six months after onset...
April 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28657451/cost-effectiveness-of-dedicated-dietitians-for-hyperphosphatemia-management-among-hemodialysis-patients-in-lebanon-results-from-the-nutrition-education-for-management-of-osteodystrophy-trial
#5
Rana Rizk, Mickaël Hiligsmann, Mirey Karavetian, Silvia M A A Evers
AIM: Assess the cost-effectiveness of nutrition education by dedicated dietitians (DD) for hyperphosphatemia management among hemodialysis patients. MATERIALS AND METHODS: This was a trial-based economic evaluation in 12 Lebanese hospital-based units. 545 prevalent patients were cluster randomized to DD, trained hospital dietitian (THD), and existing practice (EP) groups. During Phase I (6 months), DD (n = 116) received intensive education by DD trained on renal nutrition, THD (n = 299) received care from trained hospital dietitians, and EP (n = 130) received usual care from untrained hospital dietitians...
June 28, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28655781/hepatocyte-specific-hnf4%C3%AE-mir-122-pathway-contributes-to-the-iron-overload-mediated-hepatic-inflammation
#6
Min Li, Yuxiao Tang, Lusha Wu, Fengfeng Mo, Xin Wang, Hongxia Li, Ruirui Qi, Hongwei Zhang, Arun Srivastava, Chen Ling
Hepatic iron-overload (IO) is one of the major complications of transfusional therapy. It was generally thought that IO triggers substantial inflammatory responses by producing reactive oxygen species in hepatic macrophages. Recently, decrease of microRNA-122 was observed in a genetic knockout (Hfe-/-) mouse model of IO. Since hepatocyte-enriched miR-122 is known as a key regulator of multiple hepatic pathways including inflammation, it is of interest whether hepatocyte directly contributes to the IO-mediated hepatic inflammation...
June 27, 2017: Blood
https://www.readbyqxmd.com/read/28613074/blue-to-green-emitting-neutral-ir-iii-complexes-bearing-pentafluorosulfanyl-groups-a-combined-experimental-and-theoretical-study
#7
Amlan K Pal, Adam F Henwood, David B Cordes, Alexandra M Z Slawin, Ifor D W Samuel, Eli Zysman-Colman
A structure-property relationship study of neutral heteroleptic (1 and 2, [Ir(C(∧)N)2(L(∧)X)]) and homoleptic (3 and 4, fac-[Ir(C(∧)N)3]) Ir(III) complexes (where L(∧)X = anionic 2,2,6,6-tetramethylheptane-3,5-dionato-κO(3),κO(6) (thd) and C(∧)N = a cyclometalating ligand bearing a pentafluorosulfanyl (-SF5) electron-withdrawing group (EWG) at the C4 (HL1) and C3 (HL2) positions of the phenyl moiety) is presented. These complexes have been fully structurally characterized, including by single-crystal X-ray diffraction, and their electrochemical and optical properties have also been extensively studied...
July 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28610451/cognitive-function-is-largely-intact-in-methadone-maintenance-treatment-patients
#8
Odelia Elkana, Miriam Adelson, Glen M Doniger, Anat Sason, Einat Peles
OBJECTIVES: To confirm our previous findings of less cognitive impairments (based on cognitive screening tools) among methadone maintenance treatment (MMT) patients who achieved take-home dose (THD) privileges. METHODS: a random sample of 65 Israeli MMT patients were studied using computerised, age and education standardised, cognitive domains (attention, executive function, memory, motor skills), and non-computerised phonetic and semantic verbal fluency. RESULTS: Cognitive scores were within ±1 standard deviation (SD) of average for most domains, including non-verbal IQ, attention and motor skills...
July 5, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28582895/implementation-of-integrated-circuit-and-design-of-sar-adc-for-fully-implantable-hearing-aids
#9
Jong Hoon Kim, Jyung Hyun Lee, Jin-Ho Cho
BACKGOUND: The hearing impaired population has been increasing; many people suffer from hearing problems. To deal with this difficulty, various types of hearing aids are being rapidly developed. In particular, fully implantable hearing aids are being actively studied to improve the performance of existing hearing aids and to reduce the stigma of hearing loss patients. It has to be of small size and low-power consumption for easy implantation and long-term use. OBJECTIVE: The objective of the study was to implement a small size and low-power consumption successive approximation register analog-to-digital converter (SAR ADC) for fully implantable hearing aids...
May 19, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28451767/distal-doppler-guided-transanal-hemorrhoidal-dearterialization-with-mucopexy-versus-conventional-hemorrhoidectomy-for-grade-iii-and-iv-hemorrhoids-postoperative-morbidity-and-long-term-outcomes
#10
L Trenti, S Biondo, A Galvez, A Bravo, J Cabrera, E Kreisler
BACKGROUND: Distal Doppler-guided transanal hemorrhoidal dearterialization with mucopexy (Doppler-guided THD) seems to be associated with better short-term outcomes than conventional hemorrhoidectomy, but there are little data about long-term recurrence. The aim of this study was to compare Doppler-guided THD for grade III-IV hemorrhoids with conventional hemorrhoidectomy with regard to long-term postoperative morbidity and recurrence. METHODS: This was a single-center longitudinal and comparative study of a cohort of patients who underwent either distal Doppler-guided THD with low ligation of the hemorrhoidal artery and mucopexy or conventional excisional hemorrhoidectomy (Milligan and Morgan or Ferguson) for grade III and IV hemorrhoids...
April 27, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28426283/identification-of-the-proteome-complement-of-humantlk1-reveals-it-binds-and-phosphorylates-nek1-regulating-its-activity
#11
Vibha Singh, Zachary M Connelly, Xinggui Shen, Arrigo De Benedetti
The Tousled Like kinases (TLKs) are involved in numerous cellular functions, including the DNA Damage Response (DDR), but only a handful of substrates have been identified thus far. Through a novel proteomic screen, we have now identified 165 human proteins interacting with TLK1, and we have focused this work on NEK1 because of its known role in the DDR, upstream of ATR and Chk1. TLK1 and NEK1 were found to interact by coIP, and their binding is strengthened following exposure of cells to H2O2. Following incubation with doxorubicin, TLK1 and NEK1 relocalize with nuclear repair foci along with γH2AX...
May 19, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28388259/the-utility-of-mmpi-2-rf-scale-scores-in-the-differential-diagnosis-of-schizophrenia-and-major-depressive-disorder
#12
Tayla T C Lee, John R Graham, Paul A Arbisi
This study was designed to determine whether scores on selected Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) scales could be used to differentiate between individuals diagnosed with schizophrenia (SCZ) and major depressive disorder (MDD). The sample was drawn from 2 psychiatric inpatient hospitals and included data from 199 individuals with SCZ and 808 individuals with MDD. A series of multivariate analyses of variance, analyses of variance, and odds ratios were calculated to determine which MMPI-2-RF scales provide the best differentiation between individuals presenting with these 2 disorders...
April 7, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28346789/resolving-ultrafast-photoinduced-deactivations-in-water-solvated-pyrimidine-nucleosides
#13
Ana Julieta Pepino, Javier Segarra-Martí, Artur Nenov, Roberto Improta, Marco Garavelli
For the first time, ultrafast deactivations of photoexcited water-solvated pyrimidine nucleosides are mapped employing hybrid QM(CASPT2)/MM(AMBER) optimizations that account for explicit solvation, sugar effects, and dynamically correlated potential energy surfaces. Low-energy S1/S0 ring-puckering and ring-opening conical intersections (CIs) are suggested to drive the ballistic coherent subpicosecond (<200 fs) decays observed in each pyrimidine, the energetics controlling this processes correlating with the lifetimes observed...
April 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28322468/effect-of-stage-based-education-provided-by-dedicated-dietitians-on-hyperphosphataemic-haemodialysis-patients-results-from-the-nutrition-education-for-management-of-osteodystrophy-randomised-controlled-trial
#14
R Rizk, M Karavetian, M Hiligsmann, S M A A Evers
BACKGROUND: The Nutrition Education for Management of Osteodystrophy trial showed that stage-based nutrition education by dedicated dietitians surpasses existing practices in Lebanon with respect to lowering serum phosphorus among general haemodialysis patients. The present study explores the effect of nutrition education specifically on hyperphosphataemic patients from this trial. METHODS: Hyperphosphataemic haemodialysis patients were allocated to a dedicated dietitian (DD), a trained hospital dietitian (THD) and existing practice (EP) protocols...
March 21, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28269226/a-morphological-approach-to-detect-respiratory-phases-of-seismocardiogram
#15
N Alamdari, K Tavakolian, V Zakeri, R Fazel-Rezai, A Akhbardeh
This paper presents a new approach to identify the respiratory phases of heart cycles from acceleration signals (i.e., seismocardiogram) recorded from the sternum, in back to front direction. The acceleration signals were recorded simultaneously with a single lead electrocardiogram (ECG), and the respiratory signal (using a chest band strain gauge) from 20 healthy subjects. Two accelerometer-derived respiration (ADR) signals were computed by computing the lower and upper envelope of the accelerometer signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227456/a-morphological-approach-to-detect-respiratory-phases-of-seismocardiogram
#16
N Alamdari, K Tavakolian, V Zakeri, R Fazel-Rezai, A Akhbardeh, N Alamdari, K Tavakolian, V Zakeri, R Fazel-Rezai, A Akhbardeh, V Zakeri, N Alamdari, K Tavakolian, R Fazel-Rezai, A Akhbardeh
This paper presents a new approach to identify the respiratory phases of heart cycles from acceleration signals (i.e., seismocardiogram) recorded from the sternum, in back to front direction. The acceleration signals were recorded simultaneously with a single lead electrocardiogram (ECG), and the respiratory signal (using a chest band strain gauge) from 20 healthy subjects. Two accelerometer-derived respiration (ADR) signals were computed by computing the lower and upper envelope of the accelerometer signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28198909/luminescent-ybvo4-by-atomic-layer-deposition
#17
Michael Getz, Per-Anders Hansen, Mohammed A K Ahmed, Helmer Fjellvåg, Ola Nilsen
UV to visible and near-infrared converting thin films of YbVO4 have been deposited by atomic layer deposition, using the precursor combinations Yb(thd)3 (thd = 2,2,6,6-tetramethyl-3,5-heptanedione) and O3, and VO(thd)2 and O3 at a deposition temperature of 240 °C, followed by post deposition annealing at 400-1000 °C. The UV absorption and the visible and near-infrared emission have been investigated in detail. The structure, thickness and composition of the deposited films have been studied by X-ray diffraction, ellipsometry, and X-ray fluorescence, respectively...
February 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28192436/an-improved-synchronous-reference-frame-current-control-strategy-for-a-photovoltaic-grid-connected-inverter-under-unbalanced-and-nonlinear-load-conditions
#18
Amirreza Naderipour, Abdullah Asuhaimi Mohd Zin, Mohd Hafiz Bin Habibuddin, Mohammad Reza Miveh, Josep M Guerrero
In recent years, renewable energy sources have been considered the most encouraging resources for grid and off-grid power generation. This paper presents an improved current control strategy for a three-phase photovoltaic grid-connected inverter (GCI) under unbalanced and nonlinear load conditions. It is challenging to suppress the harmonic content in the output current below a pre-set value in the GCI. It is also difficult to compensate for unbalanced loads even when the grid is under disruption due to total harmonic distortion (THD) and unbalanced loads...
2017: PloS One
https://www.readbyqxmd.com/read/28000010/two-cases-demonstrating-thalidomide-s-efficacy-in-refractory-lupus-nephritis
#19
REVIEW
Rita Raturi, Avani A Patel, John D Carter
Renal involvement in systemic lupus erythematosus (SLE) is common and has been associated with an increased risk of mortality [1]. Early diagnosis is imperative to control proteinuria and prevent the progression to end-stage renal disease. Standard induction therapies include cyclophosphamide (CYC) and mycophenolate mofetil (MMF); however, it has been estimated that approximately 30% of patients are refractory to these standard treatments after 1 year [2]. We present two cases of patients diagnosed with lupus nephritis (LN) who demonstrated persistent proteinuria while on standard treatments that markedly improved after addition of thalidomide (THD)...
March 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/27977169/modulating-single-molecule-magnetic-behavior-of-a-dinuclear-erbium-iii-complex-by-solvent-exchange
#20
Jing-Yuan Ge, Long Cui, Jing Li, Fei Yu, You Song, Yi-Quan Zhang, Jing-Lin Zuo, Mohamedally Kurmoo
[Er2(thd)4Pc]·2C6H6 (1) (Hthd = 2,2,6,6-tetramethylheptanedione), obtained as green crystals from the reaction of [Er(thd)3]·2H2O with lithium phthalocyanine, Li2Pc, is a stable dinuclear complex with two Er(III) centers. Its lattice benzene solvent can be exchanged by soaking the crystals in dichloromethane to give [Er2(thd)4Pc]·2CH2Cl2 (2). The magnetic susceptibility data suggest different coupling interactions for the two complexes. While 1 exhibits fast relaxation and an estimated energy barrier of Ea = 2...
January 3, 2017: Inorganic Chemistry
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