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https://www.readbyqxmd.com/read/28543062/an-adaptive-vestibular-rehabilitation-technique
#1
Benjamin T Crane, Michael C Schubert
OBJECTIVES/HYPOTHESIS: There is a large variation in vestibular rehabilitation (VR) results depending on type of therapy, adherence, and the appropriateness for the patient's level of function. A novel adaptive vestibular rehabilitation (AVR) program was developed and evaluated. STUDY DESIGN: Technology and procedure development, and prospective multicenter trial. METHODS: Those with complete unilateral vestibular hypofunction and symptomatic at least 3 months with a Dizziness Handicap Inventory (DHI) >30 were eligible...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28533781/myelin-oligodendrocyte-glycoprotein-deciphering-a-target-in-inflammatory-demyelinating-diseases
#2
REVIEW
Patrick Peschl, Monika Bradl, Romana Höftberger, Thomas Berger, Markus Reindl
Myelin oligodendrocyte glycoprotein (MOG), a member of the immunoglobulin (Ig) superfamily, is a myelin protein solely expressed at the outermost surface of myelin sheaths and oligodendrocyte membranes. This makes MOG a potential target of cellular and humoral immune responses in inflammatory demyelinating diseases. Due to its late postnatal developmental expression, MOG is an important marker for oligodendrocyte maturation. Discovered about 30 years ago, it is one of the best-studied autoantigens for experimental autoimmune models for multiple sclerosis (MS)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28533763/is-alteration-of-tuning-property-in-cervical-vestibular-evoked-myogenic-potential-specific-for-m%C3%A3-ni%C3%A3-re-s-disease
#3
Toshihisa Murofushi, Masahito Tsubota, Ryota Suizu, Eriko Yoshimura
OBJECTIVE: The aim of this study is to show sensitivity and specificity of cervical vestibular-evoked myogenic potential (cVEMP) tuning property test to Ménière's disease (MD) in comparison with healthy controls (HC) and patients with other vestibular diseases. SUBJECTS: Totally 92 subjects (50 women and 42 men, 20-77 years of age) were enrolled in this study. Subjects were composed of 38 definite unilateral MD patients, 11 unilateral benign paroxysmal positional vertigo patients, 14 vestibular migraine patients, 19 unilateral vestibular neuritis patients, and 10 HC...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28531809/multifocal-visual-evoked-potentials-in-optic-neuritis-and-multiple-sclerosis-a-review
#4
REVIEW
Gorm Pihl-Jensen, Mathias Falck Schmidt, Jette Lautrup Frederiksen
Multifocal visual evoked potential (mf-VEP) represents a new approach to the classical full field (ff-)VEP with separate responses from up to 60 sectors of the visual field. A thorough literature survey of the use of mf-VEP in optic neuritis (ON) and multiple sclerosis (MS) is presented (38 published studies were retrieved). Mf-VEP provides direct topographical information of specific lesions and facilitates investigations on structural-functional correlations thus providing new methods for exploring the interplay between demyelination, atrophy and remyelination in MS...
April 11, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28527029/critical-flicker-fusion-frequency-in-demyelinating-and-ischemic-optic-neuropathies
#5
Matthew T Young, Puneet S Braich, Scott R Haines
PURPOSE: Critical flicker fusion (CFF) frequency is a well-studied test for evaluating demyelinating optic neuritis (ON). Its use in evaluating other optic neuropathies is not well established. The purpose of this study was to compare CFF in ON and non-arteritic anterior ischemic optic neuropathy (NAION). METHODS: We performed a retrospective review to compare multiple variables for eyes with ON or NAION using two-sided T tests and Chi-square tests. A multivariate linear regression was performed for the dependent variable CFF...
May 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28524150/-functional-examinations-of-visual-channels-clinical-aspects
#6
M V Zueva, I V Tsapenko, E P Lantukh, N M Maglakelidze
The review discusses literature data on the clinical relevance of functional assessment of magno- (M), parvo- (P), and koniocellular (K) pathways. It also covers the differential contribution of the M, P, and K channels to visual impairments and how it determines the prognosis, early diagnosis, and treatment choice in patients with neurodegenerative diseases of the retina and brain. Selective changes in the performance of the visual channels are investigated by the example of glaucoma and optic neuritis in multiple sclerosis (MS) patients...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28511578/retinal-atrophy-in-relation-to-visual-functioning-and-vision-related-quality-of-life-in-patients-with-multiple-sclerosis
#7
Lisanne J Balk, Danko Coric, Jenny A Nij Bijvank, Joep Killestein, Bernard Mj Uitdehaag, Axel Petzold
BACKGROUND: Inner retinal layer atrophy in patients with multiple sclerosis (MS) has been validated as a structural imaging biomarker for neurodegeneration. OBJECTIVE: To determine how retinal layer thickness relates to high-contrast visual acuity (HCVA), low-contrast visual acuity (LCVA) and vision-related quality of life (QoL) and to investigate the effect of previous episodes on MS-associated optic neuritis (MSON). METHODS: Spectral-domain optical coherence tomography (SD-OCT) was performed in 267 patients with MS...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28503939/clarification-of-eponymous-anatomical-terminology-structures-named-after-dr-geoffrey-v-osborne-that-compress-the-ulnar-nerve-at-the-elbow
#8
Arvin R Wali, Brandon Gabel, Madhawi Mitwalli, R Shane Tubbs, Justin M Brown
BACKGROUND: In 1957, Dr Geoffrey Osborne described a structure between the medial epicondyle and the olecranon that placed excessive pressure on the ulnar nerve. Three terms associated with such structures have emerged: Osborne's band, Osborne's ligament, and Osborne's fascia. As anatomical language moves away from eponymous terminology for descriptive, consistent nomenclature, we find discrepancies in the use of anatomic terms. This review clarifies the definitions of the above 3 terms...
May 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28503425/neuroprotective-effects-of-gypenosides-in-experimental-autoimmune-optic-neuritis
#9
Hong-Kan Zhang, Yuan Ye, Zhen-Ni Zhao, Kai-Jun Li, Yi Du, Qiu-Ming Hu, Jian-Feng He
AIM: To determine whether gypenosides have protective effects in experimental autoimmune optic neuritis (EAON). METHODS: Mice were randomly divided into seven groups: control group, model group, three different density gypenosides monotherapy, methylprednisolone monotherapy, combination of gypenosides and methylprednisolone group. The control group was subcutaneously injected with oil emulsion adjuvant and all other groups were subcutaneously immunized with an emulsified mixture of myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide to induce EAON...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28503273/bilateral-optic-neuritis-with-maculopathy-a-rare-manifestation-of-dengue-fever
#10
Y L Boo, S Y Lim, P W Chin, F K Hoo
Dengue fever is a common mosquito-borne disease, which is endemic in tropical and subtropical countries. Bilateral optic neuropathy is a relatively unusual dengue-related ocular complication. Here, we present a case of bilateral optic neuritis with maculopathy complicating dengue infection.
2017: Malaysian Family Physician
https://www.readbyqxmd.com/read/28502693/prolonged-blood-brain-barrier-disruption-following-laser-interstitial-ablation-in-epilepsy-a-case-series-with-a-case-report-of-post-ablation-optic-neuritis
#11
Saint-Aaron Morris, Matthew Rollo, Patrick Rollo, Jessica Johnson, Gerald A Grant, Elliott Friedman, Giridhar Kalamangalam, Nitin Tandon
OBJECTIVE: Laser interstitial thermal therapy (LITT) has become increasingly popular for targeting epileptic foci in a minimally invasive fashion. Despite its use in more than a thousand patients, the chronic effects of photo-thermal injury on brain physiology remain poorly understood. METHODS: We prospectively followed the clinical and radiographic courses of a cohort undergoing laser ablation for focal epilepsy. Only patients with non-enhancing lesions and those who had a delayed post-operative MRI with gadolinium administration approximately 6 months after the ablation were considered...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28502610/functional-connectivity-alterations-in-a-murine-model-of-optic-neuritis
#12
Patrick W Wright, Angela S Archambault, Stacey Peek, Adam Q Bauer, Susan M Culican, Beau M Ances, Joseph P Culver, Gregory F Wu
The basis for neuronal dysfunction following inflammatory demyelination of the central nervous system (CNS) remains poorly understood. We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an early manifestation of immune-mediated CNS demyelination in multiple sclerosis (MS). Optical intrinsic signal imaging was performed before and after the induction of ON in mice to measure changes in cortical network functional connectivity...
May 11, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28498271/epidemiology-of-dizzy-patient-population-in-a-neurotology-clinic-and-predictors-of-peripheral-etiology
#13
Thomas Muelleman, Matthew Shew, Rahul Subbarayan, Axel Shum, Kevin Sykes, Hinrich Staecker, James Lin
OBJECTIVE: To compare the proportion of peripheral versus nonperipheral dizziness etiologies among all patients, inclusive of those presenting primarily or as referrals, to rank diagnoses in order of frequency, to determine whether or not age and sex predict diagnosis, and to determine which subgroups tended to undergo formal vestibular testing. STUDY DESIGN: Retrospective cohort. SETTING: Academic neurotology clinic. PATIENTS: Age greater than 18 neurotology clinic patients with the chief complaint of dizziness...
May 11, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28497312/phenytoin-neuroprotection-or-neurotoxicity
#14
REVIEW
Jan M Keppel Hesselink, David J Kopsky
Phenytoin is an 80-year young molecule and new indications are still emerging. The neuroprotective potential of phenytoin has been evaluated for decades. Recently, a positive phase II trial supported its further development in the treatment of optic neuritis in multiple sclerosis. In 1942, however, peripheral neuritis was first reported to be an adverse event of phenytoin, and since then a small but steady stream of publications discussed peripheral polyneuropathy as being a possible adverse event of phenytoin...
May 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28495143/central-and-peripheral-nervous-system-immune-mediated-demyelinating-disease-after-allogeneic-hematopoietic-stem-cell-transplantation
#15
M I Stefanou, F Bischof
OBJECTIVE: We aimed to evaluate clinical and diagnostic features of central and peripheral immune-mediated demyelinating disease (CPID) in allogeneic hematopoietic stem cell transplantation (aHSCT) recipients. BACKGROUND: CPID refers to the late-onset, immune-mediated neurological complications following aHSCT, when other frequent differential diagnoses have been ruled out, and when symptoms and signs of systemic GvHD manifestations are absent. METHODS: Case records at the University of Tuebingen, between 2001 and 2015, were screened to identify patients with CPID after aHSCT...
June 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28491901/predictors-of-clinical-recovery-from-vestibular-neuritis-a-prospective-study
#16
Sian Cousins, Diego Kaski, Nicholas Cutfield, Qadeer Arshad, Hena Ahmad, Michael A Gresty, Barry M Seemungal, John Golding, Adolfo M Bronstein
We sought to identify predictors of symptomatic recovery in vestibular neuritis. Forty VN patients were prospectively studied in the acute phase (median = 2 days) and 32 in the recovery phase (median = 10 weeks) with vestibulo-ocular reflex, vestibular-perceptual, and visual dependence tests and psychological questionnaires. Clinical outcome was Dizziness Handicap Inventory score at recovery phase. Acute visual dependency and autonomic arousal predicted outcome. Worse recovery was associated with a combination of increased visual dependence, autonomic arousal, anxiety/depression, and fear of bodily sensations, but not with vestibular variables...
May 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28485669/postural-stability-in-a-population-of-dancers-healthy-non-dancers-and-vestibular-neuritis-patients
#17
Eduardo Martin-Sanz, Isabel Ortega Crespo, Jonathan Esteban-Sanchez, Ricardo Sanz
INTRODUCTION: Several studies have indicated better balance control in dancers than in control participants, but some controversy remains. The aim of our study is to evaluate the postural stability in a cohort of dancers, non-dancers, compensated, and non-compensated unilateral vestibular neuritis (VN). METHODS: This is a prospective study of control subjects, dancers, and VN patients between June 2009 and December 2015. Dancers from the Dance Conservatory of Madrid and VN patients were referred to our department for analysis...
May 9, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28480312/spatially-and-temporally-regulated-nrf2-gene-therapy-using-mcp-1-promoter-in-retinal-ganglion-cell-injury
#18
Kosuke Fujita, Koji M Nishiguchi, Yukihiro Shiga, Toru Nakazawa
Retinal ganglion cell degeneration triggered by axonal injury is believed to underlie many ocular diseases, including glaucoma and optic neuritis. In these diseases, retinal ganglion cells are affected unevenly, both spatially and temporally, such that healthy and unhealthy cells coexist in different patterns at different time points. Herein, we describe a temporally and spatially regulated adeno-associated virus gene therapy aiming to reduce undesired off-target effects on healthy retinal neurons. The Mcp-1 promoter previously shown to be activated in stressed retinal ganglion cells following murine optic nerve injury was combined with the neuroprotective intracellular transcription factor Nrf2...
June 16, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28477397/etiologies-of-acute-demyelinating-optic-neuritis-an-observational-study-of-110-patients
#19
R Deschamps, A Lecler, C Lamirel, J Aboab, A Gueguen, C Bensa, C Vignal, O Gout
BACKGROUND AND PURPOSE: New criteria for the diagnosis of multiple sclerosis (MS) and discovery of myelin oligodendrocyte glycoprotein (MOG) or aquaporin-4 (AQP4) antibodies (Abs) have changed the management of optic neuritis (ON). Our aim was to specify, in view of these recent advances, the etiologies of acute demyelinating ON for consecutive patients. METHODS: Retrospective database analysis was undertaken of consecutive adult patients with acute ON admitted from 1 December 2014 to 31 January 2016...
June 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28476321/murine-model-and-mechanisms-of-treatment-induced-painful-diabetic-neuropathy
#20
Juliet M Nicodemus, Cynthia Enriquez, Alexandra Marquez, Carlos J Anaya, Corinne G Jolivalt
Diabetes mellitus represents a group of metabolic diseases that are characterized by hyperglycemia caused by either lack of insulin production or a reduced ability to respond to insulin. It is estimated that there were 347 million people worldwide who suffered from diabetes in 2008 and incidence is predicted to double by 2050. Neuropathy is the most common complication of long-term diabetes and approximately 30% of these subjects develop chronic neuropathic pain. A distinct acute, severe form of neuropathic pain, called insulin neuritis or treatment-induced painful neuropathy of diabetes (TIND), may also occur shortly after initiation of intensive glycemic control, with an incidence rate of up to 10...
May 3, 2017: Neuroscience
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