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https://www.readbyqxmd.com/read/29773773/cuban-epidemic-neuropathy-insights-into-the-toxic-nutritional-hypothesis-through-international-collaboration
#1
Alina González-Quevedo, Rosaralis Santiesteban-Freixas, Janis T Eells, Lucimey Lima, Alfredo A Sadun
From 1991 to 1993, an epidemic of optic and peripheral neuropathy-the largest of the century-broke out in Cuba, affecting more than 50,000 people. Initially the main clinical features were decreased visual acuity, central and cecocentral scotomas, impaired color vision and absence of the papillomacular bundle. Later, peripheral and mixed optic-peripheral forms began to appear. Due to the magnitude of the epidemic, the Cuban government requested help from the international community at the 46th World Health Assembly in 1993...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29772575/therapeutic-effect-of-cd4-cd25-regulatory-t-cells-amplified-in-vitro-on-experimental-autoimmune-neuritis-in-rats
#2
Feng-Jie Wang, Dan Cui, Wei-Dong Qian
BACKGROUND/AIMS: This study aimed to explore whether the adoptive transfusion of autologous CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) has a therapeutic effect on Experimental autoimmune neuritis (EAN) model rats, and it provides new experimental and theoretical bases for the immunotherapy of Guillain-Barre syndrome (GBS). METHODS: CD4+CD25+ Tregs were sorted from the spleens of rats using immunomagnetic bead separation techniques combined with flow cytometry...
May 14, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29771186/cross-modal-plasticity-among-sensory-networks-in-neuromyelitis-optica-spectrum-disorders
#3
Maria Assunta Rocca, Filippo Savoldi, Paola Valsasina, Marta Radaelli, Paolo Preziosa, Giancarlo Comi, Andrea Falini, Massimo Filippi
OBJECTIVE: To explore resting-state (RS) functional connectivity (FC) of the main sensory/motor networks of patients with neuromyelitis optica spectrum disorders (NMOSDs), clinically isolated optic neuritis (ON), and myelitis. METHODS: Clinical evaluation and RS fMRI were obtained from 28 NMOSD, 11 recurrent ON, and 12 recurrent myelitis patients and 30 healthy controls. Between-group RS FC comparisons and correlations with motor performance were assessed (SPM12) on the main sensory/motor RS networks (RSNs) identified by independent component analysis...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29771078/-analysis-of-the-difference-between-the-results-of-caloric-tests-and-video-head-pulse-tests-in-patients-with-vestibular-migraine-and-vestibular-neuritis
#4
W Wang, Y C Yang, J H Zhuang, F Li, B Gao
Objective: To compare the results of caloric tests and video head impulse tests (VHIT) in patients with vestibular migraine (VM) and vestibular neuritis (VN), so as to provide help for the differential diagnosis of the two patients. Method: Retrospectively analyze VM and VN patients within 2 weeks of onset from August 1, 2016 to December 31, 2017 in neurology clinic of the Changzheng Hospital of Second Military Medical University, all patients were examined by caloric tests and VHIT, and the results of the two groups were compared and analyzed...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29767815/the-effect-of-glatiramer-acetate-on-retinal-nerve-fiber-layer-thickness-in-patients-with-relapsing-remitting-multiple-sclerosis-a-longitudinal-optical-coherence-tomography-study
#5
Robert Zivadinov, Eleonora Tavazzi, Jesper Hagemeier, Ellen Carl, David Hojnacki, Channa Kolb, Bianca Weinstock-Guttman
BACKGROUND: Optical coherence tomography (OCT) is a technique that allows for the assessment of retinal nerve fiber layer thickness (RNFLT) and total macular volume (TMV), which reflect neuroaxonal integrity within the retina. As such it has been used in multiple sclerosis (MS) to study neurodegeneration. Glatiramer acetate (GA) is a widely used treatment for MS, which is suggested to have a possible neuroprotective role. OBJECTIVE: The aim of this study was to assess RFNLT and TMV changes in relapsing-remitting MS (RRMS) patients who started treatment with GA and were followed for a 24-month period...
May 16, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29766684/neuromyelitis-optica-review-and-utility-of-testing-aquaporin-4-antibody-in-typical-optic-neuritis
#6
Meagan Seay, Janet C Rucker
Neuromyelitis optica (NMO) is an autoimmune, inflammatory demyelinating disorder often leading to severe vision impairment and disability. The discovery of a diagnostic biomarker, the aquaporin-4 antibody (AQP4-IgG), transformed the clinical diagnosis and treatment of NMO and broadened the spectrum of disease [NMO spectrum disorders (NMOSD)]. Though the antibody is highly sensitive and specific to NMOSD, routine testing in patients with typical optic neuritis is considered controversial. This article will provide a brief review of NMOSD and highlight the pros and cons of routine testing in typical optic neuritis...
May 16, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29762197/high-frequency-horizontal-semicircular-canal-function-in-certain-meni%C3%A3-re-s-disease
#7
Claudia Jerin, Rebecca Maxwell, Robert Gürkov
OBJECTIVES: To characterize video head impulse testing (vHIT) in definitive Menière's disease and to investigate the relationship between vHIT results and other audiovestibular function tests. DESIGN: Fifty-four patients with certain Menière's disease, that is, patients with clinically definite Menière's disease and endolymphatic hydrops visualized by locally enhanced inner ear MR imaging, were recruited for this study. All patients underwent vHIT. The vestibular-ocular reflex gain at 60 ms and refixation saccades were the outcome parameters measured...
May 14, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29756580/subtypes-of-antiphospholipid-antibodies-in-neurologic-accidents-an-observational-study
#8
Maryam Sahebari, Maryam Rastin, Reza Boostani, Mohsen Forughipour, Kamila Hashemzadeh, Samira HaajSadeghi
OBJECTIVE: Until now, concomitant neurological manifestations and positive antiphospholipid antibodies (APA(s)) have been investigated in different manners. The most important conflicts in this field are whether those manifestations are directly related to APA(s) or not and treatment strategies. METHOD: In this study, adopting a different manner, we selected patients with a recently defined neurological problem (according to study protocol) and positive APA without any other risk factor, to compare types, amounts, and titer of APAs...
May 14, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29754844/quantitative-magnetic-resonance-imaging-analysis-of-the-cross-sectional-areas-of-the-anconeus-epitrochlearis-muscle-cubital-tunnel-and-ulnar-nerve-with-the-elbow-in-extension-in-patients-with-and-without-ulnar-neuropathy
#9
Hing Y Eng, Drew A Gunio, Carlos L Benitez
BACKGROUND: The purpose of this study was to assess the cross-sectional area of the anconeus epitrochlearis muscle (AEM), cubital tunnel, and ulnar nerve with the elbow in extension in patients with and without ulnar neuropathy. METHODS: We performed a retrospective, level IV review of elbow magnetic resonance imaging (MRI) studies. Elbow MRI studies of 32 patients with an AEM (26 men and 6 women, aged 18-60 years), 32 randomly selected patients without an AEM (aged 16-71 years), and 32 patients with clinical ulnar neuritis (22 men and 10 women, aged 24-76 years) were reviewed...
May 10, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29754069/high-resolution-vessel-wall-mri-and-vasculopathy-related-to-herpes-zoster-ophthalmicus
#10
Jae W Song, Sam Ojeda, Javier M Romero
Varicella zoster virus is a common viral infection with over 50% of patients over the age of 80 years infected with the virus. Following reactivation, some patients succumb to complications of VZV reactivation with neurologic and optic pathway pathology such as VZV vasculopathy resulting in transient ischemic attacks, strokes, aneurysms, as well as optic neuritis. We show that high resolution vessel wall magnetic resonance imaging can aid in the diagnosis of this condition with circumferential wall thickening and enhancement of the infected vessels...
May 3, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29747362/-research-progression-of-animal-models-of-idiopathic-optic-neuritis
#11
Y X Zhang, H Yang
Idiopathic optic neuritis (ON) is an idiopathic inflammatory disease of the optic nerve. The two most common types of ON are multiple sclerosis related ON and neuromyelitis optica related ON. But so far the precise mechanisms of different types of ON have been unclear and treatments are not satisfactory. Animal disease models play critical roles in the disease mechanism research. On the other hand, with more understanding about the etiology and mechanism of ON, new models mimicking different types of ON are under development...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29747309/-etiological-analysis-on-patients-with-vertigo-or-dizziness
#12
H Xue, Y Chong, Z D Jiang, Z L Liu, L Ding, S L Yang, L Wang, W P Xiang
Objective: To explore the spectrum of causes for patients with vertigo or dizziness in the Department of Neurology, and provide a reference for diagnosis and treatment of patients with vertigo or dizziness. Methods: Clinical data of patients in the Department of Neurology, Baotou Central Hospital between January 2016 and September 2017 was retrospectively analyzed. The target group under study was diagnosed based on the uniform diagnostic criteria. Results: A total of 9 200 patients with a chief complaint of vertigo or dizziness were included...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29736281/association-of-optic-neuritis-with-cyp4f2-gene-single-nucleotide-polymorphism-and-il-17a-concentration
#13
Mantas Banevicius, Alvita Vilkeviciute, Brigita Glebauskiene, Loresa Kriauciuniene, Rasa Liutkeviciene
Background: The aetiology and pathophysiology of optic neuritis (ON) is not absolutely clear but genetic and inflammatory factors may be also involved in its development. The aim of the present study was to determine the influence of single nucleotide polymorphism (SNP) of CYP4F2 (rs1558139) and serum levels of IL-17A on ON development. Materials and Methods: Forty patients with ON and 164 control subjects were evaluated. Patients were divided by gender, also ON patients were divided into two subgroups: ON with and without multiple sclerosis (MS)...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29733809/optical-coherence-tomography-angiography-in-optic-disc-swelling
#14
Masoud Aghsaei Fard, Jalil Jalili, Alireza Sahraiyan, Hassan Khojasteh, Marjane Hejazi, Robert Ritch, Prem S Subramanian
PURPOSE: To compare optical coherence tomography angiography (OCT-A) of peripapillary total vasculature and capillaries in patients with optic disc swelling. DESIGN: Cross-sectional study. METHODS: Twenty nine eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION), 44 eyes with papilledema, 8 eyes with acute optic neuritis, and 48 eyes of normal subjects were imaged using OCT-A. Peripapillary total vasculature information was recorded using a commercial vessel density map...
May 4, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29731712/baseline-brain-activity-changes-in-patients-with-single-and-relapsing-optic-neuritis
#15
Zhuoqiong Ren, Yaou Liu, Kuncheng Li, Yunyun Duan, Huang Jing, Peipeng Liang, Zheng Sun, Xiaojun Zhang, Bei Mao
Purpose : To investigate spontaneous brain activity amplitude alterations in single and relapsing optic neuritis (sON and rON, respectively) and their relationships with clinical variables. Methods : In total, 42 patients with sON, 35 patients with rON and 50 healthy volunteers were recruited. Resting-state functional Magnetic Resonance Imaging (rs-fMRI) scans were acquired for all participants and compared to investigate the changes in the amplitude of low-frequency fluctuations (ALFFs) among the three groups...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29724464/class-i-pi3k-inhibitor-zstk474-attenuates-experimental-autoimmune-neuritis-by-decreasing-the-frequency-of-th1-th17-cells-and-reducing-the-production-of-proinflammatory-cytokines
#16
Xiuju Chen, Ying Guo, Ranran Han, Haijie Liu, Yanan Ding, Yanchao Shi, Dexin Kong, Xiaofeng Ma
The Class I phosphatidylinositol 3-kinase inhibitor, 2-(2-difluoromethy lbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine (ZSTK474), has anti-inflammatory and immunoregulatory properties. However, whether it can be used to treat Guillain-Barré syndrome (GBS)-a neuroinflammatory disorder-is unknown. We induced experimental autoimmune neuritis (EAN) in Lewis rats, an established model of GBS. Orally administered ZSTK474 decreased neurological deficits in the GBS model, as demonstrated by diminished inflammatory cell infiltration, and ameliorated demyelination of sciatic nerves...
April 26, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29724224/mog-encephalomyelitis-international-recommendations-on-diagnosis-and-antibody-testing
#17
REVIEW
S Jarius, F Paul, O Aktas, N Asgari, R C Dale, J de Seze, D Franciotta, K Fujihara, A Jacob, H J Kim, I Kleiter, T Kümpfel, M Levy, J Palace, K Ruprecht, A Saiz, C Trebst, B G Weinshenker, B Wildemann
Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD)...
May 3, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29723371/effectiveness-of-the-retreatment-of-patients-with-multibacillary-leprosy-and-episodes-of-erythema-nodosum-leprosum-and-or-persistent-neuritis-a-single-center-experience
#18
Joel Carlos Lastória, Thaís Sampaio Corrêa de Almeida, Maria Stella de Mello Ayres Putinatti, Carlos Roberto Padovani
BACKGROUND: Erythema nodosum leprosum may appear before, during or after treatment of leprosy and is one of the main factors for nerve damage in patients. When it occurs or continues to occur after treatment, it may indicate disease recurrence and a new treatment may be instituted again. OBJECTIVE: To evaluate the retreatment of patients with multibacillary leprosy who underwent standard treatment with multidrug therapy, but developed or continued to present reactions of erythema nodosum leprosum and/or neuritis 3-5 years after its end...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29721683/pediatric-neuromyelitis-optica-spectrum-disorders
#19
REVIEW
Grace Y Gombolay, Tanuja Chitnis
PURPOSE OF REVIEW: Neuromyelitis optica spectrum disorders (NMOSDs) are a group of inflammatory and demyelinating disorders of the central nervous system that can occur in children and adults. The classic presentation of NMOSD is characterized by optic neuritis and transverse myelitis, but other presentations are also recognized, expanding the disease as NMO spectrum disorders. The purpose of this review is to discuss the clinical features, along with management and treatment options, including potential future therapeutic options, in pediatric NMOSD...
May 2, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29719649/a-case-of-post-encephalitic-optic-neuritis-clinical-spectrum-differential-diagnosis-and-management
#20
Ravinder Kumar, Abhishek Bhargava, Gagan Jaiswal, Viral R Soni, Bhoomika Katbamna, Arpit Vashisht
Purpose: Most cases of optic neuritis are idiopathic or are associated with multiple sclerosis. We present a case in which a young female developed post-infectious left optic neuritis following herpes simplex encephalitis (HSE). Case Report: A 24-year-old female presented with a severe headache, fever, and malaise of a one-week duration. Viral encephalitis was diagnosed and treated; intravenous acyclovir (750 mg every 8 h) was administered for 14 days. The patient improved clinically and was prescribed oral valacyclovir (1,000 mg, three times daily) for an additional 3 months as an outpatient...
April 2018: Journal of Ophthalmic & Vision Research
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