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https://www.readbyqxmd.com/read/28102943/comparison-of-five-cluster-validity-indices-performance-in-brain-18-f-fet-pet-image-segmentation-using-k-means
#1
Bedor Abualhaj, Guoyang Weng, Melissa Ong, Ali Asgar Attarwala, Flavia Molina, Karen Büsing, Gerhard Glatting
PURPOSE: Dynamic [(18) F]fluoro-ethyl-L-tyrosine positron emission tomography ([(18) F]FET-PET) is used to identify tumor lesions for radiotherapy treatment planning, to differentiate glioma recurrence from radiation necrosis and to classify gliomas grading. To segment different regions in the brain k-means cluster analysis can be used. The main disadvantage of k-means is that the number of clusters must be pre-defined. In this study, we therefore compared different cluster validity indices for automated and reproducible determination of the optimal number of clusters based on the dynamic PET data...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102589/cover-image-volume-173a-number-2-february-2017
#2
Gilles Maussion, Cristiana Cruceanu, Jill A Rosenfeld, Scott C Bell, Fabrice Jollant, Jin Szatkiewicz, Ryan L Collins, Carrie Hanscom, Ilaria Kolobova, Nicolas Menjot de Champfleur, Ian Blumenthal, Colby Chiang, Vanessa Ota, Christina Hultman, Colm O'Dushlaine, Steve McCarroll, Martin Alda, Sebastien Jacquemont, Zehra Ordulu, Christian R Marshall, Melissa T Carter, Lisa G Shaffer, Pamela Sklar, Santhosh Girirajan, Cynthia C Morton, James F Gusella, Gustavo Turecki, Dimitri J Stavropoulos, Patrick F Sullivan, Stephen W Scherer, Michael E Talkowski, Carl Ernst
The cover image, by Carl Ernst et al., is based on the Original Article Implication of LRRC4C and DPP6 in neurodevelopmental disorders, DOI: 10.1002/ajmg.a.38021.
February 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28102343/individualised-multiplexed-circulating-tumour-dna-assays-for-monitoring-of-tumour-presence-in-patients-after-colorectal-cancer-surgery
#3
Sarah B Ng, Clarinda Chua, Matthew Ng, Anna Gan, Polly Sy Poon, Melissa Teo, Cherylin Fu, Wei Qiang Leow, Kiat Hon Lim, Alexander Chung, Si-Lin Koo, Su Pin Choo, Danliang Ho, Steve Rozen, Patrick Tan, Mark Wong, William F Burkholder, Iain Beehuat Tan
Circulating tumour DNA (ctDNA) has the potential to be a specific biomarker for the monitoring of tumours in patients with colorectal cancer (CRC). Here, our aim was to develop a personalised surveillance strategy to monitor the clinical course of CRC after surgery. We developed patient-specific ctDNA assays based on multiplexed detection of somatic mutations identified from patient primary tumours, and applied them to detect ctDNA in 44 CRC patients, analysing a total of 260 plasma samples. We found that ctDNA detection correlated with clinical events - it is detectable in pre-operative but not post-operative plasma, and also in patients with recurrent CRC...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102329/leads-in-arctic-pack-ice-enable-early-phytoplankton-blooms-below-snow-covered-sea-ice
#4
Philipp Assmy, Mar Fernández-Méndez, Pedro Duarte, Amelie Meyer, Achim Randelhoff, Christopher J Mundy, Lasse M Olsen, Hanna M Kauko, Allison Bailey, Melissa Chierici, Lana Cohen, Anthony P Doulgeris, Jens K Ehn, Agneta Fransson, Sebastian Gerland, Haakon Hop, Stephen R Hudson, Nick Hughes, Polona Itkin, Geir Johnsen, Jennifer A King, Boris P Koch, Zoe Koenig, Slawomir Kwasniewski, Samuel R Laney, Marcel Nicolaus, Alexey K Pavlov, Christopher M Polashenski, Christine Provost, Anja Rösel, Marthe Sandbu, Gunnar Spreen, Lars H Smedsrud, Arild Sundfjord, Torbjørn Taskjelle, Agnieszka Tatarek, Jozef Wiktor, Penelope M Wagner, Anette Wold, Harald Steen, Mats A Granskog
The Arctic icescape is rapidly transforming from a thicker multiyear ice cover to a thinner and largely seasonal first-year ice cover with significant consequences for Arctic primary production. One critical challenge is to understand how productivity will change within the next decades. Recent studies have reported extensive phytoplankton blooms beneath ponded sea ice during summer, indicating that satellite-based Arctic annual primary production estimates may be significantly underestimated. Here we present a unique time-series of a phytoplankton spring bloom observed beneath snow-covered Arctic pack ice...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102208/erratum-sall1-is-a-transcriptional-regulator-defining-microglia-identity-and-function
#5
Anne Buttgereit, Iva Lelios, Xueyang Yu, Melissa Vrohlings, Natalie R Krakoski, Emmanuel L Gautier, Ryuichi Nishinakamura, Burkhard Becher, Melanie Greter
No abstract text is available yet for this article.
January 19, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28102003/intervention-quality-is-not-routinely-assessed-in-cochrane-systematic-reviews-of-radiation-therapy-interventions
#6
Mohamad R Abdul Rahim, Melissa L James, Brigid E Hickey
INTRODUCTION: The aim of this study was to maximise the benefits from clinical trials involving technological interventions such as radiation therapy. High compliance to the quality assurance protocols is crucial. We assessed whether the quality of radiation therapy intervention was evaluated in Cochrane systematic reviews. METHODS: We searched 416 published Cochrane systematic reviews and identified 67 Cochrane systematic reviews that investigated radiation therapy or radiotherapy as an intervention...
January 19, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28101823/biological-activities-of-asteraceae-achillea-millefolium-and-calendula-officinalis-and-lamiaceae-melissa-officinalis-and-origanum-majorana-plant-extracts
#7
Mónica R García-Risco, Lamia Mouhid, Lilia Salas-Pérez, Alexis López-Padilla, Susana Santoyo, Laura Jaime, Ana Ramírez de Molina, Guillermo Reglero, Tiziana Fornari
Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) extracts were obtained by applying two sequential extraction processes: supercritical fluid extraction with carbon dioxide, followed by ultrasonic assisted extraction using green solvents (ethanol and ethanol:water 50:50). The extracts were analyzed in terms of the total content of phenolic compounds and the content of flavonoids; the volatile oil composition of supercritical extracts was analyzed by gas chromatography and the antioxidant capacity and cell toxicity was determined...
January 18, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28101126/characterisation-of-microbial-communities-within-aggressive-prostate-cancer-tissues
#8
Melissa A Yow, Sepehr N Tabrizi, Gianluca Severi, Damien M Bolton, John Pedersen, Graham G Giles, Melissa C Southey
BACKGROUND: An infectious aetiology for prostate cancer has been conjectured for decades but the evidence gained from questionnaire-based and sero-epidemiological studies is weak and inconsistent, and a causal association with any infectious agent is not established. We describe and evaluate the application of new technology to detect bacterial and viral agents in high-grade prostate cancer tissues. The potential of targeted 16S rRNA gene sequencing and total RNA sequencing was evaluated in terms of its utility to characterise microbial communities within high-grade prostate tumours...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28101047/acute-anterior-uveitis-in-a-patient-taking-fingolimod-fty720-for-multiple-sclerosis
#9
Heather Gwen Mack, Melissa Chih-Hui Tien, Owen Bruce White
Fingolimod is an oral sphingosine-1-phosphate (S1P) receptor modulator and the first oral therapy for relapsing-remitting multiple sclerosis. Its use has been complicated by a low rate of cystoid macular edema usually in the first 3 months after commencement of the medication. We report the case of a 34-year-old male with relapsing-remitting multiple sclerosis, who developed acute anterior uveitis on day 5 of fingolimod treatment. He responded to appropriate treatment and cessation of drug, but developed low-grade chronic anterior uveitis without cystoid macular edema...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28100586/axon-termination-pruning-and-synaptogenesis-in-the-giant-fiber-system-of-drosophila-melanogaster-is-promoted-by-highwire
#10
Melissa Borgen, Kimberly Rowland, Jana Boerner, Brandon Lloyd, Aruna Khan, Rod Murphey
The ubiquitin ligase Highwire has a conserved role in synapse formation. Here we show that Highwire coordinates several facets of central synapse formation in the Drosophila melanogaster giant fiber system, including axon termination, axon pruning, and synaptic function. Despite the similarities to the fly neuromuscular junction, the role of Highwire and the underlying signaling pathways are distinct in the fly's giant fiber system. During development, branching of the giant fiber presynaptic terminal occurs and, normally, the transient branches are pruned away...
January 18, 2017: Genetics
https://www.readbyqxmd.com/read/28100496/preexisting-immunity-not-frailty-phenotype-predicts-influenza-post-vaccination-titers-among-older-veterans
#11
Puja Van Epps, Terrence Tumpey, Melissa B Pearce, Hana Golding, Patricia Higgins, Thomas Hornick, Christopher Burant, Brigid M Wilson, Richard Banks, Stefan Gravenstein, David H Canaday
Both preexisting immunity to influenza and age have been shown to be a correlate of influenza vaccine response. Frailty, an indicator of functional impairment in older adults, has also been shown in one study to predict lower influenza vaccine responses among non-veterans. In the current study we aimed to determine the association between frailty, preexisting immunity and immune response to influenza vaccine in older veterans. We analyzed 117 subjects (age range 62-95 years; median 81) divided into 3 cohorts based on the Fried frailty test: non-frail (NF: N=23; median age 68), pre-frail (PF: N=50; median age 80) and frail (F:N=44; median age 82) during the 2010-2011 and 11-12 influenza seasons...
January 18, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28100476/chronic-anemic-hypoxemia-attenuates-glucose-stimulated-insulin-secretion-in-fetal-sheep
#12
Joshua S Benjamin, Christine B Culpepper, Laura D Brown, Stephanie R Wesolowski, Sonnet S Jonker, Melissa Ann Davis, Sean W Limesand, Randall B Wilkening, William W Hay, Paul J Rozance
Fetal insulin secretion is inhibited by acute hypoxemia. The relationship between prolonged hypoxemia and insulin secretion, however, is less well defined. To test the hypothesis that prolonged fetal hypoxemia impairs insulin secretion, studies were performed in sheep fetuses that were bled to anemic conditions for 9 ± 0 days (anemic, n=19) and compared to control fetuses (n=15). Arterial hematocrit and oxygen content were 34% and 52% lower, respectively, in anemic vs. control fetuses (P<0.0001). Plasma glucose concentrations were 21% higher in the anemic group (P<0...
January 18, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28100268/upper-lip-metastasis-of-sarcomatoid-carcinoma-of-the-lung-an-unusual-site-of-disease-a-case-report
#13
Tri Le, Melissa Mayer, Joseph Sailors, David E Gerber, John M Truelson
BACKGROUND: Lip metastases are rare clinical events that are frequently mistaken for other diagnoses. For sarcomatoid lung carcinoma, a rare histologic variant of non-small cell lung cancer, the incidence and pattern of cutaneous spread is poorly understood. CASE PRESENTATION: We present a case of a 79-year-old African American man with a rapidly progressive upper lip cutaneous lesion that provided the first evidence of distant metastatic spread of sarcomatoid lung carcinoma...
January 19, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28100258/association-between-work-time-loss-and-quality-of-life-in-patients-with-herpes-zoster-a-pooled-analysis-of-the-master-studies
#14
Emmanouil Rampakakis, Melissa Stutz, Kosuke Kawai, Tsen-Fang Tsai, Hee Jin Cheong, Jittima Dhitavat, Alejandro Ortiz-Covarrubias, Miguel Cashat-Cruz, Homero Monsanto, Kelly D Johnson, John S Sampalis, Camilo J Acosta
BACKGROUND: Herpes zoster (HZ) has a significant negative effect on the productive work life of individuals, and has been shown to be responsible for cases of absenteeism, presenteeism and decreased work effectiveness. The aim of this study was to evaluate health utility scores and associated predictors in an actively employed population of Herpes Zoster (HZ) patients with and without work time loss (WTL). METHODS: This was a pooled analysis of the prospective, observational MASTER cohort studies, conducted in 8 countries across North America, Latin America and Asia...
January 18, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28099841/targeted-inhibition-of-egfr-and-glutaminase-induces-metabolic-crisis-in-egfr-mutant-lung-cancer
#15
Milica Momcilovic, Sean T Bailey, Jason T Lee, Michael C Fishbein, Clara Magyar, Daniel Braas, Thomas Graeber, Nicholas J Jackson, Johannes Czernin, Ethan Emberley, Matthew Gross, Julie Janes, Andy Mackinnon, Alison Pan, Mirna Rodriguez, Melissa Works, Winter Zhang, Francesco Parlati, Susan Demo, Edward Garon, Kostyantyn Krysan, Tonya C Walser, Steven M Dubinett, Saman Sadeghi, Heather R Christofk, David B Shackelford
Cancer cells exhibit increased use of nutrients, including glucose and glutamine, to support the bioenergetic and biosynthetic demands of proliferation. We tested the small-molecule inhibitor of glutaminase CB-839 in combination with erlotinib on epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) as a therapeutic strategy to simultaneously impair cancer glucose and glutamine utilization and thereby suppress tumor growth. Here, we show that CB-839 cooperates with erlotinib to drive energetic stress and activate the AMP-activated protein kinase (AMPK) pathway in EGFR (del19) lung tumors...
January 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/28099730/development-updates-and-future-directions-of-the-world-health-organization-selected-practice-recommendations-for-contraceptive-use
#16
Melissa J Chen, Caron R Kim, Katherine C Whitehouse, Erin Berry-Bibee, Mary E Gaffield
No abstract text is available yet for this article.
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099673/accelerated-second-degree-bachelor-of-science-in-nursing-graduates-transition-to-professional-practice
#17
Cheryl L Brandt, Melissa R Boellaard, Kaitlyn M Wilberding
: HOW TO OBTAIN CONTACT HOURS BY READING THIS ISSUE Instructions: 1.2 contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded after you register, pay the registration fee, and complete the evaluation form online at http://goo...
January 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/28099587/non-invasive-ventilation-in-patients-with-heart-failure-a-systematic-review-and-meta-analysis
#18
Hugo Souza Bittencourt, Helena França Correia Dos Reis, Melissa Santos Lima, Mansueto Gomes
Non-invasive ventilation (NIV) may perfect respiratory and cardiac performance in patients with heart failure (HF). The objective of the study to establish, through systematic review and meta-analysis, NIV influence on functional capacity of HF patients. A systematic review with meta-analysis of randomized studies was carried out through research of databases of Cochrane Library, SciELO, Pubmed and PEDro, using the key-words: heart failure, non-invasive ventilation, exercise tolerance; and the free terms: bi-level positive airway pressure (BIPAP), continuous positive airway pressure (CPAP), and functional capacity (terms were searched for in English and Portuguese) using the Boolean operators AND and OR...
January 16, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28099487/metabolic-imaging-of-head-and-neck-cancer-organoids
#19
Amy T Shah, Tiffany M Heaster, Melissa C Skala
Head and neck cancer patients suffer from toxicities, morbidities, and mortalities, and these ailments could be minimized through improved therapies. Drug discovery is a long, expensive, and complex process, so optimized assays can improve the success rate of drug candidates. This study applies optical imaging of cell metabolism to three-dimensional in vitro cultures of head and neck cancer grown from primary tumor tissue (organoids). This technique is advantageous because it measures cell metabolism using intrinsic fluorescence from NAD(P)H and FAD on a single cell level for a three-dimensional in vitro model...
2017: PloS One
https://www.readbyqxmd.com/read/28099074/new-developments-in-breast-cancer-screening-and-treatment
#20
Sarah Tilstra, Melissa McNeil
The clinical update serves as a brief review of recently published, high-impact, and potentially practice-changing journal articles summarized for our readers. In this clinical update, we selected top recent articles regarding breast health that may change the clinical practice of women's health providers. We identified articles by reviewing high-impact medical and women's health journals as well as national practice guidelines. Three of our articles are dedicated to the rapid changes in breast cancer screening...
January 2017: Journal of Women's Health
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