keyword
MENU ▼
Read by QxMD icon Read
search

Melissa

keyword
https://www.readbyqxmd.com/read/28239471/gene-expression-markers-of-tumor-infiltrating-leukocytes
#1
Patrick Danaher, Sarah Warren, Lucas Dennis, Leonard D'Amico, Andrew White, Mary L Disis, Melissa A Geller, Kunle Odunsi, Joseph Beechem, Steven P Fling
BACKGROUND: Assays of the abundance of immune cell populations in the tumor microenvironment promise to inform immune oncology research and the choice of immunotherapy for individual patients. We propose to measure the intratumoral abundance of various immune cell populations with gene expression. In contrast to IHC and flow cytometry, gene expression assays yield high information content from a clinically practical workflow. Previous studies of gene expression in purified immune cells have reported hundreds of genes showing enrichment in a single cell type, but the utility of these genes in tumor samples is unknown...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28239367/b10-cell-frequencies-and-suppressive-capacity-in-myasthenia-gravis-are-associated-with-disease-severity
#2
John S Yi, Melissa A Russo, Janice M Massey, Vern Juel, Lisa D Hobson-Webb, Karissa Gable, Shruti M Raja, Kristina Balderson, Kent J Weinhold, Jeffrey T Guptill
Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated disease. The mechanisms for loss of self-tolerance in this disease are not well understood, and recently described regulatory B cell (Breg) subsets have not been thoroughly investigated. B10 cells are a subset of Bregs identified by the production of the immunosuppressive cytokine, interleukin-10 (IL-10). B10 cells are known to strongly inhibit B- and T-cell inflammatory responses in animal models and are implicated in human autoimmunity. In this study, we examined quantitative and qualitative aspects of B10 cells in acetylcholine receptor autoantibody positive MG (AChR-MG) patients and healthy controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28238980/evidence-based-care-for-the-elderly-uses-of-the-grandmother-principle
#3
Samuel K Williams, Joanne M Braxton, Melissa Gosdin, Nathan Nobis, Denise A Williams
No abstract text is available yet for this article.
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28238352/reliable-mite-specific-ige-testing-in-nasal-secretions-by-means-of-allergen-microarray
#4
Margot Berings, Stefania Arasi, Natalie De Ruyck, Serena Perna, Yvonne Resch, Christian Lupinek, Kuan-Wei Chen, Susanne Vrtala, Giovanni Battista Pajno, Claus Bachert, Bart N Lambrecht, Melissa Dullaers, Rudolf Valenta, Paolo Maria Matricardi, Philippe Gevaert
No abstract text is available yet for this article.
February 18, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28237839/systemic-aav8-mediated-gene-therapy-drives-whole-body-correction-of-myotubular-myopathy-in-dogs
#5
David L Mack, Karine Poulard, Melissa A Goddard, Virginie Latournerie, Jessica M Snyder, Robert W Grange, Matthew R Elverman, Jérôme Denard, Philippe Veron, Laurine Buscara, Christine Le Bec, Jean-Yves Hogrel, Annie G Brezovec, Hui Meng, Lin Yang, Fujun Liu, Michael O'Callaghan, Nikhil Gopal, Valerie E Kelly, Barbara K Smith, Jennifer L Strande, Fulvio Mavilio, Alan H Beggs, Federico Mingozzi, Michael W Lawlor, Ana Buj-Bello, Martin K Childers
X-linked myotubular myopathy (XLMTM) results from MTM1 gene mutations and myotubularin deficiency. Most XLMTM patients develop severe muscle weakness leading to respiratory failure and death, typically within 2 years of age. Our objective was to evaluate the efficacy and safety of systemic gene therapy in the p.N155K canine model of XLMTM by performing a dose escalation study. A recombinant adeno-associated virus serotype 8 (rAAV8) vector expressing canine myotubularin (cMTM1) under the muscle-specific desmin promoter (rAAV8-cMTM1) was administered by simple peripheral venous infusion in XLMTM dogs at 10 weeks of age, when signs of the disease are already present...
February 22, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28237835/integration-of-a-cd19-car-into-the-tcr-alpha-chain-locus-streamlines-production-of-allogeneic-gene-edited-car-t-cells
#6
Daniel T MacLeod, Jeyaraj Antony, Aaron J Martin, Rachel J Moser, Armin Hekele, Keith J Wetzel, Audrey E Brown, Melissa A Triggiano, Jo Ann Hux, Christina D Pham, Victor V Bartsevich, Caitlin A Turner, Janel Lape, Samantha Kirkland, Clayton W Beard, Jeff Smith, Matthew L Hirsch, Michael G Nicholson, Derek Jantz, Bruce McCreedy
Adoptive cellular therapy using chimeric antigen receptor (CAR) T cell therapies have produced significant objective responses in patients with CD19(+) hematological malignancies, including durable complete responses. Although the majority of clinical trials to date have used autologous patient cells as the starting material to generate CAR T cells, this strategy poses significant manufacturing challenges and, for some patients, may not be feasible because of their advanced disease state or difficulty with manufacturing suitable numbers of CAR T cells...
February 22, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28237375/maternal-mental-health-and-neonatal-intensive-care-unit-discharge-readiness-in-mothers-of-preterm-infants
#7
Elisabeth C McGowan, Nan Du, Katheleen Hawes, Richard Tucker, Melissa O'Donnell, Betty Vohr
OBJECTIVE: To evaluate associations between maternal mental health disorders (MHDs) and discharge readiness for mothers of infants born preterm (<37 weeks). We hypothesized that mothers with a history of MHDs would report decreased perceptions of neonatal intensive care unit (NICU) discharge readiness compared with mothers without a history. STUDY DESIGN: Mothers of infants born preterm in the NICU >5 days between 2012 and 2015 and participating in a transition home program completed a discharge readiness questionnaire measuring perceptions of staff support, infant well-being (medical stability), maternal well-being (emotional readiness/competency), and maternal comfort (worry about infant)...
February 22, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28237212/value-assessment-at-the-point-of-care-incorporating-patient-values-throughout-care-delivery-and-a-draft-taxonomy-of-patient-values
#8
Melissa J Armstrong, C Daniel Mullins
Incorporation of patient values is a key element of patient-centered care, but consistent incorporation of patient values at the point of care is lacking. Shared decision making encourages incorporation of patient values in decision making, but associated tools often lack guidance on value assessment. In addition, focusing on patient values relating only to specific decisions misses an opportunity for a more holistic approach to value assessment that could impact other aspects of clinical encounters, including health care planning, communication, and stakeholder involvement...
February 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28236979/histologic-transformation-of-egfr-mutant-lung-adenocarcinoma-without-exposure-to-egfr-inhibition
#9
Tri Le, Joseph Sailors, Dwight H Oliver, Melissa Mayer, Sharon Hoskin, David E Gerber
Resistance to EGFR kinase inhibitors appears to be invariable in the treatment of non-small cell lung cancer. Several mechanisms have been described. Here, we report the first case of histologic transformation of EGFR mutant lung adenocarcinoma without prior exposure to EGFR inhibition.
March 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28236547/screening-for-beta-lactam-allergy-in-joint-arthroplasty-patients-to-improve-surgical-prophylaxis-practice
#10
Deanna L McDanel, Antoine E Azar, Amy M Dowden, Samantha Murray-Bainer, Nicolas O Noiseux, Melissa Willenborg, Charles R Clark, John J Callaghan, Ambar Haleem
BACKGROUND: The reliability of patient-reported penicillin allergies has been disputed. A Drug Allergy Clinic (DAC) was established at our institution in combination with an electronic best practice alert (BPA) in the Orthopedic Clinic. Joint arthroplasty patients with a reported history of beta-lactam allergy (HOBA) were preoperatively referred via the BPA to the DAC. The purpose of this study was to determine the effectiveness of beta-lactam allergy screening in enabling the surgical team to optimize antimicrobial prophylaxis...
January 17, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28236480/effect-of-biodiesel-fuel-on-real-world-nonroad-heavy-duty-diesel-engine-particulate-matter-emissions-composition-and-cytotoxicity
#11
Nathan Martin, Melissa Lombard, Kirk R Jensen, Patrick Kelley, Tara Pratt, Nora Traviss
Biodiesel is regarded by many as a "greener" alternative fuel to petroleum diesel with potentially lower health risk. However, recent studies examining biodiesel particulate matter (PM) characteristics and health effects are contradictive, and typically utilize PM generated by passenger car engines in laboratory settings. There is a critical need to analyze diesel and biodiesel PM generated in a "real-world" setting where heavy duty-diesel (HDD) engines and commercially purchased fuel are utilized. This study compares the mass concentrations, chemical composition and cytotoxicity of real-world PM from combustion of both petroleum diesel and a waste grease 20% biodiesel blend (B20) at a community recycling center operating HDD nonroad equipment...
February 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28236457/impact-of-diabetes-mellitus-on-ischemic-events-in-men-and-women-after-percutaneous-coronary-intervention
#12
Serdar Farhan, Usman Baber, Birgit Vogel, Melissa Aquino, Jaya Chandrasekhar, Michela Faggioni, Gennaro Giustino, Alexandra Kautzky-Willer, Joesph Sweeny, Srushti Shah, Pooja Vijay, Nitin Barman, Pedro Moreno, Jason Kovacic, George Dangas, Annapoorna Kini, Roxana Mehran, Samin Sharma
Studies have shown worse outcome for women compared with men after percutaneous coronary intervention (PCI), especially in the presence of diabetes mellitus (DM). We aimed to investigate the risk of ischemic events after PCI in women versus men stratified by the presence or absence of DM. A total of 17,154 consecutive patients from a single-center PCI registry enrolled from January 2009 to December 2014 were categorized accordingly: female/non-DM, female/DM, male/non-DM, and male/DM. End points included death and myocardial infarction (MI) at 1 year...
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28236295/the-interplay-among-children-s-negative-family-representations-visual-processing-of-negative-emotions-and-externalizing-symptoms
#13
Patrick T Davies, Jesse L Coe, Rochelle F Hentges, Melissa L Sturge-Apple, Erika van der Kloet
This study examined the transactional interplay among children's negative family representations, visual processing of negative emotions, and externalizing symptoms in a sample of 243 preschool children (Mage  = 4.60 years). Children participated in three annual measurement occasions. Cross-lagged autoregressive models were conducted with multimethod, multi-informant data to identify mediational pathways. Consistent with schema-based top-down models, negative family representations were associated with attention to negative faces in an eye-tracking task and their externalizing symptoms...
February 25, 2017: Child Development
https://www.readbyqxmd.com/read/28236107/in-vitro-fertilization-for-women-infected-by-hepatitis-c-virus-a-matched-case-control-study-and-a-systematic-literature-review
#14
Chloë Shaw-Jackson, Mélissa Capraro, Lieveke Ameye, Jean Vandromme, Yannick Manigart, Serge Rozenberg, Candice Autin
PURPOSE: The aim of this study was to investigate whether infection of women by the hepatitis C virus (HCV) reduces the chance of conceiving after in vitro fertilization (IVF). METHODS: We performed a retrospective blind matched case-control study where IVF outcomes for the first 37 cycles of HCV sero-positive women were compared to those of 107 cycles of an uninfected control group. Our results were included in a systematic literature review. RESULTS: Out of five eligible studies, ours included, three observed an impact of HCV infection, though at various levels including response to stimulation, fertilization, implantation, and pregnancy rates...
February 24, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28236039/validation-of-an-instrument-to-assess-barriers-to-care-seeking-for-accidental-bowel-leakage-in-women-the-bcabl-questionnaire
#15
Heidi Wendell Brown, Meg E Wise, Danielle Westenberg, Nicholas B Schmuhl, Kelly Lewis Brezoczky, Rebecca G Rogers, Melissa L Constantine
INTRODUCTION AND HYPOTHESIS: Fewer than 30% of women with accidental bowel leakage (ABL) seek care, despite the existence of effective, minimally invasive therapies. We developed and validated a condition-specific instrument to assess barriers to care-seeking for ABL in women. METHODS: Adult women with ABL completed an electronic survey about condition severity, patient activation, previous care-seeking, and demographics. The Barriers to Care-seeking for Accidental Bowel Leakage (BCABL) instrument contained 42 potential items completed at baseline and again 2 weeks later...
February 24, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28236031/structural-dependence-of-meh-ppv-chromism-in-solution
#16
Carlos E T de Magalhães, Ranylson M L Savedra, Karina S Dias, Rodrigo Ramos, Melissa F Siqueira
The chromism observed in the MEH-PPV polymer in tetrahydrofuran (THF) solution is discussed as a function of the structural morphology of the backbone chains. To evaluate this phenomenon, we carried out simulations employing a hybrid methodology using molecular dynamics and quantum mechanical approaches. Our results support the hypothesis that the morphological order-disorder transition is related to the change from red to blue phase observed experimentally. The morphological disorder is associated with total or partial twisted arrangements in the polymer backbone, which induces an electronic conjugation length more confined to shorter segments...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28235969/how-do-organisational-characteristics-influence-teamwork-and-service-delivery-in-lung-cancer-diagnostic-assessment-programmes-a-mixed-methods-study
#17
Gladys N Honein-AbouHaidar, Terri Stuart-McEwan, Tom Waddell, Alexandra Salvarrey, Jennifer Smylie, Mark J Dobrow, Melissa C Brouwers, Anna R Gagliardi
OBJECTIVES: Diagnostic assessment programmes (DAPs) can reduce wait times for cancer diagnosis, but optimal DAP design is unknown. This study explored how organisational characteristics influenced multidisciplinary teamwork and diagnostic service delivery in lung cancer DAPs. DESIGN: A mixed-methods approach integrated data from descriptive qualitative interviews and medical record abstraction at 4 lung cancer DAPs. Findings were analysed with the Integrated Team Effectiveness Model...
February 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28235833/early-life-exposures-predicting-onset-and-resolution-of-childhood-overweight-or-obesity
#18
Jessica A Kerr, Catherine Long, Susan A Clifford, Joshua Muller, Alanna N Gillespie, Susan Donath, Melissa Wake
OBJECTIVES: To determine which of multiple early-life exposures predict onset or resolution of overweight/obesity during a 9-year period. METHODS: Design: longitudinal cohort from three harmonised community-based cohorts enriched for overweight and obesity. Early-life exposures: child-gestational age; delivery; birth weight; breast feeding; solids introduction; baseline body mass index (BMI); waist circumference; diet; activity; global, physical and psychosocial health...
February 24, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28235685/the-molluscum-contagiosum-virus-protein-mc163-localizes-to-the-mitochondria-and-dampens-mitochondrial-mediated-apoptotic-responses
#19
Jesse Coutu, Melissa R Ryerson, Joachim Bugert, Daniel Brian Nichols
Apoptosis is a powerful host cell defense to prevent viruses from completing replication. Poxviruses have evolved complex means to dampen cellular apoptotic responses. The poxvirus, Molluscum Contagiosum Virus (MCV), encodes numerous host interacting molecules predicted to antagonize immune responses. However, the function of the majority of these MCV products has not been characterized. Here, we show that the MCV MC163 protein localized to the mitochondria via an N-terminal mitochondrial localization sequence and transmembrane domain...
February 21, 2017: Virology
https://www.readbyqxmd.com/read/28235657/effects-of-chronic-waterborne-cadmium-and-zinc-interactions-on-tissue-specific-metal-accumulation-and-reproduction-in-fathead-minnow-pimephales-promelas
#20
Melissa K Driessnack, Ankur Jamwal, Som Niyogi
The present study was designed to evaluate the interactive effects of chronic waterborne cadmium (Cd) and zinc (Zn) on tissue-specific metal accumulation and reproduction in fathead minnow (Pimephales promelas). Trios (1 male: 2 female; n=6-7) of fish were exposed for 21 days to: (i) control (no added Cd or Zn), (ii) waterborne Cd (7µg/L), (iii) waterborne Zn (170µg/L), and (iv) Cd and Zn in mixture (7 and 170µg/L, respectively). Exposure to Cd or Zn alone did not elicit any significant effect on reproductive output (cumulative egg production) relative to the control, however exposure to Cd and Zn in mixture resulted in a ~50% decrease in fish fecundity...
February 21, 2017: Ecotoxicology and Environmental Safety
keyword
keyword
80800
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"