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https://www.readbyqxmd.com/read/29346342/attention-deficit-hyperactivity-disorder-medication-prescription-claims-among-privately-insured-women-aged-15-44-years-united-states-2003-2015
#1
Kayla N Anderson, Elizabeth C Ailes, Melissa Danielson, Jennifer N Lind, Sherry L Farr, Cheryl S Broussard, Sarah C Tinker
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects individuals across the lifespan. ADHD medication use among pregnant women is increasing (1), but consensus about the safety of ADHD medication use during pregnancy is lacking. Given that nearly half of U.S. pregnancies are unintended (2), and early pregnancy is a critical period for fetal development, examining trends in ADHD medication prescriptions among reproductive-aged women is important to quantify the population at risk for potential exposure...
January 19, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29346002/intermittent-preventive-therapy-in-pregnancy-and-incidence-of-low-birth-weight-in-malaria-endemic-countries
#2
Jordan E Cates, Daniel Westreich, Holger W Unger, Melissa Bauserman, Linda Adair, Stephen R Cole, Steven Meshnick, Stephen J Rogerson
OBJECTIVES: To estimate the impact of hypothetical antimalarial and nutritional interventions (which reduce the prevalence of low midupper arm circumference [MUAC]) on the incidence of low birth weight (LBW). METHODS: We analyzed data from 14 633 pregnancies from 13 studies conducted across Africa and the Western Pacific from 1996 to 2015. We calculated population intervention effects for increasing intermittent preventive therapy in pregnancy (IPTp), full coverage with bed nets, reduction in malaria infection at delivery, and reductions in the prevalence of low MUAC...
January 18, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29345963/deletion-of-estrogen-receptor-alpha-in-skeletal-muscle-results-in-impaired-contractility-in-female-mice
#3
Brittany C Collins, Tara L Mader, Christine A Cabelka, Melissa R Iñigo, Espen E Spangenburg, Dawn A Lowe
Estradiol deficiency in females can result in skeletal muscle strength loss, and treatment with estradiol mitigates the loss. There are three primary estrogen receptors and estradiol elicits effects through these receptors in various tissues. Ubiquitous estrogen receptor α (ERα) knockout mice exhibit numerous biological disorders, but little is known regarding the specific role of ERα in skeletal muscle contractile function. The purpose of this study was to determine the impact of skeletal muscle specific ERα deletion on contractile function, hypothesizing that ERα is a main receptor through which estradiol affects muscle strength in females...
January 18, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29345878/impact-of-cognitive-impairment-on-functioning-in-patients-with-depression
#4
Raymond W Lam
Reassessing a patient's diagnosis if he or she does not respond adequately to initial antidepressant pharmacotherapy is imperative. In this CME activity, evaluate the case of Melissa, a 32-year-old architect with a potential case of treatment-resistant depression, and decide on appropriate treatment strategies.
November 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29345597/pediatric-markers-of-adult-cardiovascular-disease
#5
Micah Olson, Melissa Chambers, Gabe Shaibi
Cardiovascular disease (CVD) is the leading cause of mortality in the United States . Atherosclerotic CV events do not occur until adulthood, except in the context of rare genetic disorders such as homozygous familial hypercholesterolemia. However, the atherogenic process that leads to CVD begins in childhood and progresses throughout the lifespan . The degree of atherosclerosis early in life is associated with established risk factors for CVD (e.g. family history, obesity, dyslipidemia), indicating that the development and progression of atherosclerosis in childhood is driven by genetic as well as environmental factors...
January 16, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29345476/adapting-a-parenting-intervention-for-parents-aging-out-of-the-child-welfare-system-a-systematic-approach-to-expand-the-reach-of-an-evidence-based-intervention
#6
Kendal Holtrop, Angela I Canto, Lisa Schelbe, Lenore M McWey, Melissa Radey, Jordan E Montgomery
Parents aging out of the child welfare system face a constellation of unique risk factors that threaten the well-being of themselves and their children. Although parenting interventions are an important resource for providing much-needed services to parents aging out, there is currently a lack of evidence-based parenting interventions that address the unique needs of this population. The purpose of this project was to systematically adapt an evidence-based parenting intervention for parents aging out. An established adaptation framework was used to guide this process, and acceptability and feasibility outcomes were evaluated as part of a pilot study of the adapted intervention...
January 18, 2018: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/29344716/safety-and-effectiveness-of-palliative-tunneled-peritoneal-drainage-catheters-in-the-management-of-refractory-malignant-and-non-malignant-ascites
#7
Jennifer A Knight, Scott M Thompson, Chad J Fleming, Emily C Bendel, Melissa J Neisen, Newton B Neidert, Andrew H Stockland, Haraldur Bjarnason, David A Woodrum
PURPOSE: To determine the safety and effectiveness of tunneled peritoneal catheters in the management of refractory malignant and non-malignant ascites. MATERIALS AND METHODS: An IRB-approved retrospective review was undertaken of patients who underwent ultrasound and fluoroscopy-guided tunneled peritoneal catheter placement for management of refractory malignant or non-malignant ascites between January 1, 2009, and March 14, 2014. RESULTS: A total of 137 patients (76 M/61 F, mean age 62...
January 17, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29344698/concentrations-of-cadmium-copper-and-zinc-in-macrobrachium-rosenbergii-giant-freshwater-prawn-from-natural-environment
#8
Farah Akmal Idrus, Masania Mohd Basri, Khairul Adha A Rahim, Nur Syazwani Abd Rahim, Melissa Dennis Chong
This study analyzed the levels of cadmium (Cd), copper (Cu), and zinc (Zn) by the flame atomic absorption spectrophotometer (FAAS), in the muscle tissues, exoskeletons, and gills from freshwater prawn (Macrobrachium rosenbergii) (n = 20) harvested from natural habitat in Kerang River, Malaysia on 25th November 2015. Significant increase of the metals level in muscle tissue and gill (r > 0.70, p < 0.05) were observed with increase in length except for Cu in gills. No relationship was found between metals level in exoskeleton and length...
January 17, 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29344620/association-of-depression-with-mortality-in-older-adults-undergoing-transcatheter-or-surgical-aortic-valve-replacement
#9
Laura M Drudi, Matthew Ades, Sena Turkdogan, Caroline Huynh, Sandra Lauck, John G Webb, Nicolo Piazza, Giuseppe Martucci, Yves Langlois, Louis P Perrault, Anita W Asgar, Marino Labinaz, Andre Lamy, Nicolas Noiseux, Mark D Peterson, Rakesh C Arora, Brian R Lindman, Melissa Bendayan, Rita Mancini, Amanda Trnkus, Dae H Kim, Jeffrey J Popma, Jonathan Afilalo
Importance: Depression is increasingly recognized as a risk factor for adverse outcomes in cardiovascular disease. However, little is known about depression in older adults undergoing transcatheter (TAVR) or surgical (SAVR) aortic valve replacement. Objective: To determine the prevalence of depression and its association with all-cause mortality in older adults undergoing TAVR or SAVR. Design, Setting, and Participants: This preplanned analysis of the Frailty Aortic Valve Replacement (FRAILTY-AVR) prospective cohort study included 14 centers in 3 countries from November 15, 2011, through April 7, 2016...
January 17, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29343977/cost-effectiveness-analysis-of-six-therapies-for-the-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#10
James C Ulchaker, Melissa S Martinson
Objective: To conduct a cost-effectiveness analysis from payers' perspectives of six treatments for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and to examine positioning of these modalities in the marketplace for the best use of health care funds and quality-of-life benefits for patients. Methods: The economic analysis was conducted with a Markov model to compare combination prescription drug therapy (ComboRx), minimally invasive therapies (MITs) including convective radiofrequency (RF) water vapor thermal therapy (Rezūm®), conductive RF thermal therapy (Prostiva®), and prostatic urethral lift (UroLift®), and invasive surgical procedures including photovaporization of the prostate (Greenlight® PVP) and transurethral resection of the prostate (TURP)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29343837/neurocognitive-dysfunction-in-hematopoietic-cell-transplant-recipients-expert-review-from-the-late-effects-and-quality-of-life-working-committee-of-the-cibmtr-and-complications-and-quality-of-life-working-party-of-the-ebmt
#11
REVIEW
David Buchbinder, Debra Lynch Kelly, Rafael F Duarte, Jeffery J Auletta, Neel Bhatt, Michael Byrne, Zachariah DeFilipp, Melissa Gabriel, Anuj Mahindra, Maxim Norkin, Helene Schoemans, Ami J Shah, Ibrahim Ahmed, Yoshiko Atsuta, Grzegorz W Basak, Sara Beattie, Sita Bhella, Christopher Bredeson, Nancy Bunin, Jignesh Dalal, Andrew Daly, James Gajewski, Robert Peter Gale, John Galvin, Mehdi Hamadani, Robert J Hayashi, Kehinde Adekola, Jason Law, Catherine J Lee, Jane Liesveld, Adriana K Malone, Arnon Nagler, Seema Naik, Taiga Nishihori, Susan K Parsons, Angela Scherwath, Hannah-Lise Schofield, Robert Soiffer, Jeff Szer, Ida Twist, Anne B Warwick, Baldeep M Wirk, Jean Yi, Minoo Battiwalla, Mary D E Flowers, Bipin Savani, Bronwen E Shaw
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT...
January 17, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29343178/impact-of-clinical-pharmacists-on-atherosclerotic-risk-factor-management-in-an-integrated-heart-and-vascular-clinic
#12
Marie N Waddles, Ginny Mitchell, Melissa J Snider, Michael R Go, Talal Attar
No abstract text is available yet for this article.
January 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29343150/eight-year-outcomes-of-a-competency-based-residency-training-program-in-orthopedic-surgery
#13
Markku T Nousiainen, Polina Mironova, Melissa Hynes, Susan Glover Takahashi, Richard Reznick, William Kraemer, Benjamin Alman, Peter Ferguson
BACKGROUND: The Division of Orthopaedic Surgery at the University of Toronto implemented a pilot residency training program that used a competency-based framework in July of 2009. The competency-based curriculum (CBC) deployed an innovative, modularized approach that dramatically intensified both the structured learning elements and the assessment processes. METHODS: This paper discusses the initial curriculum design of the CBC pilot program; the refinement of the curriculum using curriculum mapping that allowed for efficiencies in educational delivery; details of evaluating resident competence; feedback from external reviews by accrediting bodies; and trainee and program outcomes for the first eight years of the program's implementation...
January 18, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29342502/antiphospholipid-antibodies-inhibit-trophoblast-toll-like-receptor-and-inflammasome-negative-regulators
#14
Melissa J Mulla, Ingrid C Weel, Julie A Potter, Stefan M Gysler, Jane E Salmon, Maria T S Peraçoli, Carla V Rothlin, Lawrence W Chamley, Vikki M Abrahams
OBJECTIVE: Women with antiphospholipid antibodies (aPL) are at risk for pregnancy complications associated with poor placentation and placental inflammation. While these antibodies are heterogeneous, some anti-β2 GPI antibodies can activate human first trimester trophoblast TLR4 and NLRP3. The objective of this study was to determine the role of negative regulators of TLR and inflammasome function in aPL-induced trophoblast inflammation. METHODS: Human trophoblast cells were treated with or without anti-β2 GPI aPL or control IgG in the presence or absence of the common TAM receptor ligand, GAS6, or the autophagy inducer, rapamycin...
January 17, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29342320/association-of-pre-esrd-serum-calcium-with-post-esrd-mortality-among-incident-esrd-patients-a-cohort-study
#15
Yoshitsugu Obi, Christina Park, Melissa Soohoo, Keiichi Sumida, Takayuki Hamano, Connie M Rhee, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Elani Streja
Albumin-corrected serum calcium (cSCa) decline at late stages of chronic kidney disease and rise after dialysis initiation. While hypercalcemia is associated with higher mortality in end-stage renal disease (ESRD), there are scarce data on the impact of pre-ESRD cSCa on post-ESRD mortality. Therefore, we used a large national cohort of 21,826 US veterans with incident ESRD who transitioned to dialysis in all US Department of Veterans Affairs healthcare facilities over 2009-2014 to examine the associations with all-cause and cause-specific post-ESRD mortality of (1) cSCa concentrations averaged over the last six months and (2) its rate of decline during the last 12 months before dialysis initiation...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29342251/kinetics-of-serological-responses-in-critically-ill-patients-hospitalized-with-influenza-a-h1n1-pdm09-virus-infection-in-canada-2009-2011
#16
Melissa A Rolfes, F Liaini Gross, Brendan Flannery, Adrienne F A Meyers, Ma Luo, Nathalie Bastien, Robert A Fowler, Jacqueline M Katz, Min Z Levine, Anand Kumar, Timothy M Uyeki
Background: The kinetics of the antibody response during severe influenza are not well documented. Methods: Critically ill patients with influenza A(H1N1)pdm09 virus infection, confirmed by RT-PCR or seroconversion (≥4-fold rise in titers), during 2009-2011 in Canada were prospectively studied. Antibody titers in serially collected sera were determined using hemagglutinin inhibition (HAI) and microneutralization assays. Average antibody curves were estimated using linear mixed effects models and compared by patient outcome, age, and corticosteroid treatment...
January 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29342143/regulation-of-embryonic-haematopoietic-multipotency-by-ezh1
#17
Linda T Vo, Melissa A Kinney, Xin Liu, Yuannyu Zhang, Jessica Barragan, Patricia M Sousa, Deepak K Jha, Areum Han, Marcella Cesana, Zhen Shao, Trista E North, Stuart H Orkin, Sergei Doulatov, Jian Xu, George Q Daley
All haematopoietic cell lineages that circulate in the blood of adult mammals derive from multipotent haematopoietic stem cells (HSCs). By contrast, in the blood of mammalian embryos, lineage-restricted progenitors arise first, independently of HSCs, which only emerge later in gestation. As best defined in the mouse, 'primitive' progenitors first appear in the yolk sac at 7.5 days post-coitum. Subsequently, erythroid-myeloid progenitors that express fetal haemoglobin, as well as fetal lymphoid progenitors, develop in the yolk sac and the embryo proper, but these cells lack HSC potential...
January 17, 2018: Nature
https://www.readbyqxmd.com/read/29341877/characterizing-the-effects-of-insertion-of-a-5-2%C3%A2-kb-region-of-a-vacv-genome-which-contains-known-immune-evasion-genes-on-mva-immunogenicity
#18
Melissa R Ryerson, Joanna L Shisler
Modified Vaccinia virus Ankara (MVA) is an attenuated Vaccinia virus (VACV) that is a popular vaccine vector candidate against many different pathogens. Its replication-restricted nature makes it a safe vaccine. However, higher doses or multiple boosts of MVA are necessary to elicit an immune response similar to wild-type VACV. Multiple strategies have been used to create modified MVA viruses that remain safe, but have increased immunogenicity. For example, one common strategy is to delete MVA immunomodulatory proteins in hopes of increasing the host immune response...
January 13, 2018: Virus Research
https://www.readbyqxmd.com/read/29341866/identifying-low-grade-cellular-rejection-after-heart-transplantation-in-children-using-gene-expression-profiling
#19
Annie Xin, Melissa G Y Lee, Yifang Hu, Vera Ignjatovic, William Y Shi, Anne Shipp, Slavica Praporski, Axel Kallies, Robert G Weintraub, Paul T Monagle, Gordon K Smyth, Igor Konstantinov
BACKGROUND: Endomyocardial biopsy (EMB) remains the gold standard for detecting rejection after heart transplantation but is costly and invasive. This study aims to distinguish no rejection (0R) from low-grade rejection (1R/2R) after heart transplantation in children by global gene expression profiling in blood. METHODS: A total of 106 blood samples with corresponding EMB from 18 children who underwent heart transplantation from 2011-2014 were analyzed (18 baseline/pre-transplantation samples, 88 EMB samples)...
December 20, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29341859/an-indoor-air-quality-evaluation-in-a-residential-retrofit-project-using-spray-polyurethane-foam
#20
Shen Tian, Scott Ecoff, John Sebroski, Jason Miller, Harold Rickenbacker, Melissa Bilec
Understanding of indoor air quality (IAQ) during and after spray polyurethane foam (SPF) application is essential to protect the health of both workers and building occupants. Previous efforts such as field monitoring, micro-chamber/spray booth emission studies and fate/transport modeling have been conducted to understand the chemical exposure of SPF and guide risk mitigation strategies. However, each type of research has its limitation and can only reveal partial information on the relationship between SPF and IAQ...
January 17, 2018: Journal of Occupational and Environmental Hygiene
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