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https://www.readbyqxmd.com/read/28927224/supraorbital-keyhole-craniotomy-for-basilar-artery-aneurysms-accounting-for-the-cliff-effect
#1
Melissa M Stamates, Andrew K Wong, Anita Bhansali, Ricky H Wong
BACKGROUND: Treatment of basilar artery aneurysms is challenging. While endovascular techniques have dominated, there still remain circumstances where open surgical clipping is required or preferred. Minimally invasive "keyhole" approaches are being used more frequently to provide the durability of surgical clipping with a lower morbidity profile; however, careful patient selection is required. The supraorbital "keyhole" approach has been described for the treatment of basilar artery aneurysms, but careful assessment of the basilar exposure is necessary to ensure proper visualization of the aneurysm and ability to obtain proximal vascular control...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28926940/stress-exposure-and-physical-mental-and-behavioral-health-among-american-indian-adults-with-type-2-diabetes
#2
Melissa L Walls, Kelley J Sittner, Benjamin D Aronson, Angie K Forsberg, Les B Whitbeck, Mustafa al'Absi
American Indian (AI) communities experience disproportionate exposure to stressors and health inequities including type 2 diabetes. Yet, we know little about the role of psychosocial stressors for AI diabetes-related health outcomes. We investigated associations between a range of stressors and psychological, behavioral, and physical health for AIs with diabetes. This community-based participatory research with 5 AI tribes includes 192 AI adult type 2 diabetes patients recruited from clinical records at tribal clinics...
September 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926827/one-year-follow-up-of-girls-with-precocious-puberty-and-their-mothers-do-psychological-assessments-change-over-time-or-with-treatment
#3
Melissa J Schoelwer, Kelly L Donahue, Paula Didrick, Erica A Eugster
BACKGROUND: To determine whether psychological characteristics of girls with variations of early puberty and their mothers change over time and with treatment in girls with central precocious puberty (CPP). METHODS: Girls with CPP, premature adrenarche (PA), and early normal puberty (ENP) completed psychological assessments at baseline and after 1 year along with their mothers. All girls with CPP were treated with GnRH analogs. Psychological effects of group and time were examined using 2 × 3 mixed ANOVAs...
September 19, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28926767/stabilization-of-t4-bacteriophage-at-acidic-and-basic-ph-by-adsorption-on-paper
#4
Abigail Meyer, Melissa Greene, Chad Kimmelshue, Rebecca Cademartiri
Bacteriophages find applications in agriculture, medicine, and food safety. Many of these applications can expose bacteriophages to stresses that inactivate them including acidic and basic pH. Bacteriophages can be stabilized against these stresses by materials including paper, a common material in packaging and consumer products. Combining paper and bacteriophages creates antibacterial materials, which can reduce the use of antibiotics. Here we show that adsorption on paper protects T4, T5, and T7 bacteriophage from acidic and basic pH...
September 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28926546/-t-betting-on-innate-lymphoid-cells-in-cns-inflammatory-disease
#5
Melissa A Brown, Abigail E Russi
No abstract text is available yet for this article.
September 19, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28926459/disseminated-cutaneous-herpes-in-a-patient-with-rheumatoid-arthritis
#6
Melissa Nobrega Vasques de Freitas, Mariana Ortega Perez, Thaís Carvalho Barboza, Maria Lourdes Peris Barbo
No abstract text is available yet for this article.
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28926374/reducing-urban-violence-a-contrast-of-public-health-and-criminal-justice-approaches
#7
Magdalena Cerdá, Melissa Tracy, Katherine M Keyes
BACKGROUND: Cities are investing millions in Cure Violence, a public health approach to reduce urban violence by targeting at-risk youth and redirecting conflict to non-violent responses. The impact of such a program compared to criminal justice responses is unknown because experiments directly comparing criminal justice and public health approaches to violence prevention are infeasible with observational data. We simulated experiments to test the influence of two interventions on violence: a) Cure Violence; and b) directed police patrol in violence hot spots...
September 18, 2017: Epidemiology
https://www.readbyqxmd.com/read/28926296/randomised-controlled-trial-of-urokinase-versus-placebo-for-non-draining-malignant-pleural-effusion
#8
Eleanor K Mishra, Amelia O Clive, Genevieve H Wills, Helen E Davies, Andrew E Stanton, Mohamed Al-Aloul, Alan Hart-Thomas, Justin Pepperell, Matthew Evison, Tarek Saba, Richard Neil Harrison, Anur Guhan, Matthew E Callister, Ramamurthy Sathyamurthy, Sunita Rehal, John P Corcoran, Robert Hallifax, Ioannis Psallidas, Nicky Russell, Rachel Shaw, Melissa Dobson, John M Wrightson, Alex West, Y C Gary Lee, Andrew J Nunn, Robert F Miller, Nick A Maskell, Najib M Rahman
RATIONALE: Patients with malignant pleural effusion (MPE) experience breathlessness, which is treated by drainage and pleurodesis. Incomplete drainage results in residual dyspnea and pleurodesis failure. Intrapleural fibrinolytics lyse septations within pleural fluid, improving drainage. OBJECTIVES: To assess the effects of intrapleural urokinase on dyspnea and pleurodesis success in patients with non-draining malignant effusion. METHODS: Prospective double blind randomised trial; patients with non-draining effusion were randomly allocated 1:1 to intrapleural urokinase (100,000 IU three doses 12 hourly) or matched placebo...
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28925740/household-air-pollution-is-associated-with-altered-cardiac-function-among-women-in-kenya
#9
Anubha Agarwal, Kipruto Kirwa, Melissa N Eliot, Fawaz Alenezi, Diana Menya, Sumeet S Mitter, Eric J Velazquez, Rajesh Vedanthan, Gregory A Wellenius, Gerald S Bloomfield
No abstract text is available yet for this article.
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28925358/preconditioned-cues-have-no-value
#10
Melissa Sharpe, Hannah Batchelor, Geoffrey Schoenbaum
Sensory preconditioning has been used to implicate midbrain dopamine in model-based learning, contradicting the view that dopamine transients reflect model-free value. However, it has been suggested that model-free value might accrue directly to the preconditioned cue through mediated learning. Here, building on previous work (Sadacca et al., 2016), we address this question by testing whether a preconditioned cue will support conditioned reinforcement in rats. We found that while both directly conditioned and second-order conditioned cues supported robust conditioned reinforcement, a preconditioned cue did not...
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28924594/can-we-now-recommend-otsc-as-first-line-therapy-in-case-of-non-variceal-upper-gastrointestinal-bleeding
#11
EDITORIAL
Shannon Melissa Chan, James Yw Lau
No abstract text is available yet for this article.
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28924228/an-expanded-role-for-heterozygous-mutations-of-abcb4-abcb11-atp8b1-abcc2-and-tjp2-in-intrahepatic-cholestasis-of-pregnancy
#12
Peter H Dixon, Melissa Sambrotta, Jennifer Chambers, Pamela Taylor-Harris, Argyro Syngelaki, Kypros Nicolaides, A S Knisely, Richard J Thompson, Catherine Williamson
Intrahepatic cholestasis of pregnancy (ICP) affects 1/140 UK pregnancies; with pruritus, hepatic impairment and elevated serum bile acids. Severe disease is complicated by spontaneous preterm delivery and stillbirth. Previous studies have reported mutations in hepatocellular transporters (ABCB4, ABCB11). High throughput sequencing in 147 patients was performed in the transporters ABCB4, ABCB11, ATP8B1, ABCC2 and tight junction protein 2 (TJP2). Twenty-six potentially damaging variants were identified with the following predicted protein changes: Twelve ABCB4 mutations - Arg47Gln, Met113Val, Glu161Gly, Thr175Ala, Glu528Glyfs*6, Arg590Gln, Ala601Ser, Glu884Ter, Gly722Ala, Tyr775Met (x2), Trp854Ter...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924015/no-mediates-nitrite-sensing-and-adaptation-and-triggers-a-remodeling-of-lipids
#13
Lina J Dolch, Josselin Lupette, Guillaume Tourcier, Mariette Bedhomme, Séverine Collin, Leonardo Magneschi, Melissa Conte, Khawla Seddiki, Christelle Richard, Erwan Corre, Laurent Fourage, Frédéric Laeuffer, Robert Richards, Michael Reith, Fabrice Rébeillé, Juliette Jouhet, Patrick McGinn, Eric Marechal
Nitric oxide (NO) is an intermediate of the nitrogen cycle, an industrial pollutant and a marker of climate change. NO also acts as a gaseous transmitter in a variety of biological processes. The impact of environmental NO needs to be addressed. In diatoms, a dominant phylum in phytoplankton, NO was reported to mediate programmed cell death (PCD) in response to diatom derived polyunsaturated aldehydes. Here, using the Phaeodactylum Pt1 strain, 2E,4E-decadienal supplied in the micromolar concentration range led to a non-specific cell toxicity...
September 18, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28923866/changing-antimalarial-drug-sensitivities-in-uganda
#14
Stephanie A Rasmussen, Frida G Ceja, Melissa D Conrad, Patrick K Tumwebaze, Oswald Byaruhanga, Thomas Katairo, Samuel L Nsobya, Philip J Rosenthal, Roland A Cooper
Dihydroartemisinin-piperaquine (DP) has demonstrated excellent efficacy for the treatment and prevention of malaria in Uganda. However, resistance to both components of this regimen has emerged in Southeast Asia. The efficacy of artemether-lumefantrine, the first-line regimen to treat malaria in Uganda, has also been excellent, but continued pressure may select for parasites with decreased sensitivity to lumefantrine. To gain insight into current drug sensitivity patterns, ex vivo sensitivities were assessed and genotypes previously associated with altered drug sensitivity were characterized for 58 isolates collected in Tororo, Uganda from subjects presenting in 2016 with malaria from the community or as part of a clinical trial comparing DP chemoprevention regimens...
September 18, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28923761/surgical-treatment-of-obstructive-sleep-apnea-on-cardiovascular-outcomes-a-systematic-review
#15
Tyler R Halle, Melissa S Oh, Nancy A Collop, Arshed A Quyyumi, Donald L Bliwise, Raj C Dedhia
BACKGROUND: Obstructive sleep apnea (OSA) is an increasingly prevalent clinical problem with significant effects on quality of life and cardiovascular risk. Surgical therapy represents an important treatment for those unable to use positive airway pressure. This systematic review examines the available cardiovascular risk reduction data for surgical treatment of OSA. METHODS: A comprehensive literature search was performed. Articles were included if they met the following criteria: (1) adults >18 years (2) OSA diagnosed by sleep study; (3) surgical intervention performed for OSA; (4) one or more physical or biochemical cardiovascular and/or cerebrovascular variables was measured pre-operatively and at ≥14 days postoperatively...
September 15, 2017: Chest
https://www.readbyqxmd.com/read/28923120/high-dose-interleukin-2-hd-il-2-for-advanced-melanoma-a-single-center-experience-from-the-university-of-pittsburgh-cancer-institute
#16
Diwakar Davar, Fei Ding, Melissa Saul, Cindy Sander, Ahmad A Tarhini, John M Kirkwood, Hussein A Tawbi
BACKGROUND: Durable remissions are observed in a fraction of metastatic melanoma patients treated with high-dose interleukin-2 (HD IL-2). Early studies reported overall (OR) and complete response (CR) rates of 16% and 8% respectively. Toxicity limited use to specialized centers with standardized protocols. We report on 243 patients treated at the University of Pittsburgh in a non-intensive care unit (ICU) oncology specialty setting. METHODS: Clinical and radiological data were collected on 243 patients treated between 1992 and 2015...
September 19, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28922956/dmts-is-an-effective-treatment-in-both-inhalation-and-injection-models-for-cyanide-poisoning-using-unanesthetized-mice
#17
Susan M DeLeon, Jason D Downey, Diane M Hildenberger, Melissa O Rhoomes, Lamont Booker, Gary A Rockwood, Kelly A Basi
CONTEXT: Cyanide (CN) is a metabolic poison, halting ATP synthesis by inhibiting complex IV of the electron transport chain. If exposed at high enough concentrations, humans and most animals can die within minutes. Because time is a crucial factor in survival of CN poisoning, a rapidly bioavailable, nontoxic, easy to administer CN medical countermeasure could improve morbidity/mortality in a mass CN exposure scenario. The most likely route of exposure to CN is via inhalation. OBJECTIVE: This study examined the efficacy of a new formulation for dimethyl trisulfide (DMTS), a countermeasure which has shown promise as a treatment for CN poisoning, using both inhalation and injection models of CN exposure...
September 19, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28922675/clinical-characteristics-and-long-term-outcome-of-primary-aldosteronism-in-a-norwegian-population
#18
Marianne Aardal Grytaas, Siri S Strømsøy, Jarle Tor Rørvik, Jarle Birger Arnes, Anette Heie, Thomas Arnesen, Melissa D Jørstad, Bjørn Gunnar Nedrebø, Dag Erik Jøssang, Dag Kjartan Jensen, Håvard D Rørvik, Jørn Vegard Sagen, Gunnar Mellgren, Hrafnkell B Thordarson, Eystein Sverre Husebye, Kristian Løvås
No abstract text is available yet for this article.
September 18, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28922591/baseline-characteristics-and-early-response-at-week-1-predict-treatment-outcome-in-adolescents-with-bipolar-manic-or-mixed-episode-treated-with-olanzapine-results-from-a-3-week-randomized-placebo-controlled-trial
#19
Le Xiao, Stephen J Ganocy, Robert L Findling, Kiki Chang, Melissa P DelBello, John M Kane, Mauricio Tohen, Yu-Tao Xiang, Christoph U Correll
BACKGROUND: Early predictors of response and remission in pediatric mania are lacking, requiring further study. METHODS: This was a post hoc analysis of a 3-week, randomized, placebo-controlled trial of olanzapine conducted between November 2002 and May 2005 in 161 adolescents aged 13-17 years who were diagnosed with a DSM-IV acute manic or mixed episode of bipolar I disorder. Data from the olanzapine arm were analyzed to investigate the predictive power of early response or early nonresponse (≥25% or < 25% reduction in Young Mania Rating Scale [YMRS] score, respectively) at week 1 for ultimate response or nonresponse (≥ 50% or < 50% reduction in YMRS score, respectively) and for remission (YMRS total score ≤ 12 [standard definition] or ≤ 8 [stringent definition]) at week 3...
September 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28922540/ape1-ref-1-knockdown-in-pancreatic-ductal-adenocarcinoma-characterizing-gene-expression-changes-and-identifying-novel-pathways-using-single-cell-rna-sequencing
#20
Fenil Shah, Emery Goossens, Nadia M Atallah, Michelle Grimard, Mark R Kelley, Melissa L Fishel
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1 or APE1) is a multifunctional protein that regulates numerous transcription factors associated with cancer-related pathways. Because APE1 is essential for cell viability, generation of APE1 knockout cell lines and determining a comprehensive list of genes regulated by APE1 has not been possible. To circumvent this challenge, we utilized single-cell RNA Sequencing to identify differentially expressed genes in relation to APE1 protein levels within the cell...
September 18, 2017: Molecular Oncology
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