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MIMIC database

Xiangjun Liu, Xiaohui Xu
Osteoporosis is defined as a loss of bone mass and deterioration of its architecture resulting in bone weakness, which becomes prone to fracture. The objective of this study was to investigate the molecular mechanism by which miR-137 can reduce the risk of fracture in patients with osteoporosis. An online miRNA database and a luciferase reporter assay system were used to confirm that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4) was the target of miR-137. Real-time PCR and western blot analysis were used to study miR-137 mRNA, the expression of LGR4 mRNA and protein among different groups or cells transfected with a scrambled miRNA control, miR-137 mimic, LGR4 siRNA and miR-137 inhibitor...
May 17, 2018: International Journal of Molecular Medicine
Y-W Chu, C-R Wang, F-B Weng, Z-J Yan, C Wang
OBJECTIVE: The aim of this study was to investigate the role of microRNA-222 (miR-222) in osteosarcoma (OS), and to further explore the potential molecular mechanism. PATIENTS AND METHODS: We measured the level of miR-222 in OS tissues and cell lines using quantitative Real-time polymerase chain reaction. Synthesized miR-222 mimics or inhibitors were obtained to up-regulate or down-regulate the expression of miR-222 in U2OS or Saos2 cells. Cell counting kit-8 (CCK8) and colony formation assay were employed to detect the ability of cell proliferation, and transwell assay was used to confirm the ability of cell invasion...
May 2018: European Review for Medical and Pharmacological Sciences
H-Y Du, B Liu
OBJECTIVE: As breast cancer has become the most common malignant tumor in women worldwide and several microRNAs involved in the mechanism of breast cancer development and progression have been identified, we aimed at investigating the role of miR-1271 in breast cancer. PATIENTS AND METHODS: By quantitative Real-time polymerase chain reaction (qRT-PCR), miR-1271 expression levels in 94 pairs of breast cancer tissue samples and five breast cancer-derived cell lines were detected...
May 2018: European Review for Medical and Pharmacological Sciences
Kaiyuan Li, Cong Feng, Lijing Jia, Li Chen, Fei Pan, Tanshi Li
To introduce Medical Information Mart for Intensive Care (MIMIC) database and elaborate the approach of critically emergent research with big data based on the feature of MIMIC and updated studies both domestic and overseas, we put forward the feasibility and necessity of introducing medical big data to research in emergency. Then we discuss the role of MIMIC database in emergency clinical study, as well as the principles and key notes of experimental design and implementation under the medical big data circumstance...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Claire-Audrey Y Bayan, Trisha Khanna, Veronica Rotemberg, Faramarz H Samie, Nathalie C Zeitouni
Extramammary Paget's Disease (EMPD) is a rare intraepithelial adenocarcinoma that classically manifests with pruritic, erythematous, scaling plaques. The clinical picture frequently mimics inflammatory or infectious conditions, and is thus commonly misdiagnosed. The assessment of tumor margins is equally challenging as tumors have a propensity to spread beyond clinically visible boundaries. Appropriate non-invasive diagnostic tools can assist in the early detection, diagnosis, and management of EMPD. This paper will review the literature on non-invasive imaging modalities used in EMPD...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Sarika Sahu, Atmakuri Ramakrishna Rao, Jaya Pandey, Kishor Gaikwad, Sabari Ghoshal, Trilochan Mohapatra
Long non coding RNAs (lncRNAs) are a class of non-protein coding RNAs that play a crucial role in most of the biological activities like nodule metabolism, flowering time and male sterility. Quite often, the function of lncRNAs is species-specific in nature. Thus an attempt has been made in cluster bean (Cyamopsis tetragonoloba) for the first time to computationally identify lncRNAs based on a proposed index and study their targeted genes. Further, these targeted genes of lncRNAs were identified and characterized for their role in various biological processes like stress mechanisms, DNA damage repair, cell wall synthesis...
May 10, 2018: Gene
Jorge Sancho, Álvaro Alesanco, José García
The photoplethysmogram (PPG) is a biomedical signal that can be used to estimate volumetric blood flow changes in the peripheral circulation. During the past few years, several works have been published in order to assess the potential for PPGs to be used in biometric authentication systems, but results are inconclusive. In this paper we perform an analysis of the feasibility of using the PPG as a realistic biometric alternative in the long term. Several feature extractors (based on the time domain and the Karhunen⁻Loève transform) and matching metrics (Manhattan and Euclidean distances) have been tested using four different PPG databases (PRRB, MIMIC-II, Berry, and Nonin)...
May 11, 2018: Sensors
Yan-Xin Fan, Xiu-Hua Bian, Pu-Dong Qian, Zhen-Zhang Chen, Jing Wen, Yan-Hong Luo, Peng-Wei Yan, Qian Zhang
MicroRNAs (miRNAs) have been reported to regulate the expression of genes by suppressing translation or facilitating mRNA decay. Their expression regulates a wide variety of cellular processes, including the development and progression of cancer. Esophageal squamous cell carcinoma (ESCC) is a malignant cancer with high morbidity and recurrence in Asia. In the present study, the biological function of miR-125b and its underlying mechanism in ESCC were explored. The results revealed that miR-125b expression was significantly decreased in ESCC tissues and cell lines...
May 2, 2018: Oncology Reports
Xinling Zhang, Qianqian Huo, Wei Sun, Chunxiang Zhang, Zongyin Wu, Bing Xing, Qiang Li
Depression has been well established as an independent predictor of mortality and cardiac morbidity rates in patients with coronary artery disease (CAD). Evidence has shown that single nucleotide polymorphisms located in pre‑microRNA (miRNA) or mature miRNA may modify various biological processes and affect the process of carcinogenesis, and the downregulation of neuronal nitric oxide synthase 1 (NOS1) can induce depression. It has been shown that NOS1 is the target gene of miR‑146a, and that the rs2910164 G/C polymorphism can downregulate the expression of miR‑146a...
April 26, 2018: Molecular Medicine Reports
Mohamed Salem, Jacob A O'Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye, Jelena Brkić, Asma Amleh, Barbara C Vanderhyden, Basel Refky, Burton B Yang, Sergey N Krylov, Chun Peng
MicroRNAs (miRNAs) play important roles in gene regulation, and their dysregulation is associated with many diseases including epithelial ovarian cancer (EOC). In this study, we determined the expression and function of miR-590-3p in EOC. miR-590-3p levels were higher in high-grade carcinoma when compared to low-grade or tumors with low malignant potential. Interestingly, plasma levels of miR-590-3p were significantly higher in EOC patients than in subjects with benign gynecological disorders. Transient transfection of miR-590-3p mimics or stable transfection of mir-590 increased cell proliferation, migration, and invasion...
May 10, 2018: Cancer Research
Kirsten Bulteel, Merijn Mestdagh, Francis Tuerlinckx, Eva Ceulemans
In psychology, modeling multivariate dynamical processes within a person is gaining ground. A popular model is the lag-one vector autoregressive or VAR(1) model and its variants, in which each variable is regressed on all variables (including itself) at the previous time point. Many parameters have to be estimated in the VAR(1) model, however. The question thus rises whether the VAR(1) model is not too complex and overfits the data. If the latter is the case, the estimated model will not properly predict new unseen data...
May 10, 2018: Psychological Methods
Zengding Liu, Ji Chen, Minfang Tang
Aiming at the defects that the traditional pulse transit time (PTT) detection methods are sensitive to changes in photoplethysmography (PPG) signal and require heavy computation, we proposed a new algorithm to detect PTT based on waveform time domain feature and dynamic difference threshold. We calculated the PTT by using dynamic difference threshold method to detect the R-waves of electrocardiogram (ECG), shortening the main peak detection range in PPG signal according to the characteristics of the waveform time domain, and using R wave to detect the main peak of PPG signal...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
D Joshua Mancini, Brian P Smith, Travis M Polk, C William Schwab
Introduction: Little is known regarding the confidence of military surgeons prior to combat zone deployment. Military surgeons are frequently deployed without peers experienced in combat surgery. We hypothesized that forward surgical team experience (FSTE) increases surgeon confidence with critical skill sets. Methods: We conducted a national survey of military affiliated personnel. We used a novel survey instrument that was piloted and validated by experienced military surgeons to collect demographics, education, practice patterns, and confidence parameters for trauma and surgical critical care skills...
May 8, 2018: Military Medicine
Shuangzhe Yao, Xihui Jiang, Chao Sun, Zhongqing Zheng, Bangmao Wang, Tao Wang
PURPOSE: The LiFe (liver, injury, failure, evaluation) score, calculated according to arterial lactate, total bilirubin, and INR, is a novel score for risk prediction in ICU patients with cirrhosis. The present study aimed to externally validate and optimize the LiFe score for predicting outcomes in critically ill cirrhosis patients. METHODS: The study employed the single-center database Medical Information Mart for Intensive Care-III (MIMIC-III) for analysis. A total of 536 critically ill cirrhosis patients from the MIMIC-III database were analyzed...
May 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Siobhan Murphy, Ask Elklit, Yoke Yong Chen, Siti Raudzah Ghazali, Mark Shevlin
OBJECTIVE: Evidence has suggested there are sex differences in posttraumatic stress disorder (PTSD) symptom expression; however, few studies have assessed whether these differences are due to measurement invariance. This study aimed to examine sex differences in PTSD symptoms based on the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) using differential item functioning (DIF). METHOD: Confirmatory factor analysis was conducted on the DSM-5 model of PTSD, followed by a multiple indicators multiple causes (MIMIC) model to examine possible DIF using the PTSD Checklist for DSM-5...
May 3, 2018: Psychological Trauma: Theory, Research, Practice and Policy
Pedro Jimenez-Sandoval, Ezequiel A Madrigal-Carrillo, Hugo A Santamaría-Suárez, Daniel Maturana, Itzel Rentería-González, Claudia G Benitez-Cardoza, Alfredo Torres-Larios, Luis G Brieba
Antibodies recognize protein targets with great affinity and specificity. However, posttranslational modifications and the presence of intrinsic disulfide-bonds pose difficulties for their industrial use. The immunoglobulin fold is one of the most ubiquitous folds in nature and it is found in many proteins besides antibodies. An example of a protein family with an immunoglobulin-like fold is the Cysteine Protease Inhibitors (ICP) family I42 of the MEROPs database for protease and protease inhibitors. Members of this protein family are thermostable and do not present internal disulfide bonds...
April 26, 2018: Proteins
James D Anderst, Shannon L Carpenter, Rodney Presley, Molly Curtin Berkoff, Allison P Wheeler, Robert F Sidonio, J Michael Soucie
BACKGROUND: Bleeding disorders and abusive head trauma (AHT) are associated with intracranial hemorrhage (ICH), including subdural hemorrhage (SDH). Because both conditions often present in young children, the need to screen for bleeding disorders would be better informed by data that include trauma history and are specific to young children. The Universal Data Collection database contains information on ICH in subjects with bleeding disorders, including age and trauma history. Study objectives were to (1) characterize the prevalence and calculate the probabilities of any ICH, traumatic ICH, and nontraumatic ICH in children with congenital bleeding disorders; (2) characterize the prevalence of spontaneous SDH on the basis of bleeding disorder; and (3) identify cases of von Willebrand disease (vWD) that mimic AHT...
April 25, 2018: Pediatrics
Qi-Bing Wu, Jing Chen, Jia-Wei Zhu, Xin Yin, He-Yang You, Yi-Rong Lin, Hua-Qing Zhu
Colorectal cancer (CRC) is one of the major types of cancer and causes of mortality worldwide, and it remains the third most common cause of cancer‑associated mortality worldwide. MicroRNAs (miRNAs) are a class of small RNAs, which have been shown to be associated with CRC. In the present study, an MTT assay and proliferating cell nuclear antigen (PCNA) protein examination assay were performed to detect RKO cell viability. Hoechst staining, and caspase‑3 activity and BrdU incorporation assays were performed to detect RKO cell apoptosis, respectively...
April 18, 2018: International Journal of Molecular Medicine
Matteo Perini, Mauro Paolini, Federica Camin, Giovanni Appendino, Francesca Vitulo, Eric De Combarieu, Nicola Sardone, Ernesto Marco Martinelli, Roberto Pace
Saw palmetto (Serenoa repens, SP) is the most expensive oil source of the pharmaceutical and healthfood market, and its high cost and recurrent shortages have spurred the development of designer blends of fatty acids to mimic its phytochemical profile and fraudulently comply with the current authentication assays. To detect this adulteration, the combined use of isotopic fingerprint and omic analysis has been investigated, using Principal Component Analysis (PCA) to handle the complex databases generated by these techniques and to identify the possible source of the adulterants...
April 21, 2018: Fitoterapia
Joel C Davies, Harley H L Chan, Jonathan M Bernstein, David P Goldstein, Jonathan C Irish, Ralph W Gilbert
PURPOSE: Current nonvascular osseous reconstructive options for reconstruction of the orbital floor after maxillectomy include options such as scapular tip and iliac crest bone grafts. The aim of this study was to determine whether these donor sites were morphologically comparable with the orbital floor. MATERIALS AND METHODS: A retrospective cross-sectional study design was selected. By use of a pre-existing melanoma database (January 1, 2005, through September 20, 2015), computed tomography scans of the head, neck, thorax, and pelvis were obtained from patients without evidence of bony metastases...
March 28, 2018: Journal of Oral and Maxillofacial Surgery
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