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MIMIC database

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https://www.readbyqxmd.com/read/28711593/clinical-evaluation-of-sepsis-1-and-sepsis-3-in-the-intensive-care-unit
#1
Xueling Fang, Zhenzhen Wang, Jun Yang, Hongliu Cai, Zhengjie Yao, Kun Li, Qiang Fang
BACKGROUND: There has been considerable controversy between sepsis-1 and sepsis-3 criteria. METHODS: Patients with infection meeting SIRS ≥ 2 criteria (sepsis-1) or a SOFA score ≥ 2 (sepsis-3) on the first day after ICU admission were selected from the MIMIC-III database, and their outcomes were compared using all-cause death as the endpoint. Subgroup analysis was also performed based on prior chronic organ dysfunction. RESULTS: 21,491 infected patients were included...
July 12, 2017: Chest
https://www.readbyqxmd.com/read/28680767/a-resident-boot-camp-for-reducing-door-to-needle-times-at-academic-medical-centers
#2
REVIEW
Ilana M Ruff, Ava L Liberman, Fan Z Caprio, Matthew B Maas, Scott J Mendelson, Farzaneh A Sorond, Deborah Bergman, Richard A Bernstein, Yvonne Curran, Shyam Prabhakaran
BACKGROUND: We sought to determine if a structured educational program for neurology residents can lower door-to-needle (DTN) times at an academic institution. METHODS: A neurology resident educational stroke boot camp was developed and implemented in April 2013. Using a prospective database of 170 consecutive acute ischemic stroke (AIS) patients treated with IV tissue plasminogen activator (tPA) in our emergency department (ED), we evaluated the effect of the intervention on DTN times...
June 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/28669749/extracellular-vesicles-in-gastrointestinal-cancer-in-conjunction-with-microbiota-on-the-border-of-kingdoms
#3
REVIEW
Natasha S Barteneva, Yeldar Baiken, Elizaveta Fasler-Kan, Kenneth Alibek, Sheng Wang, Natalia Maltsev, Eugeny D Ponomarev, Zarina Sautbayeva, Sholpan Kauanova, Anna Moore, Christoph Beglinger, Ivan A Vorobjev
Extracellular vesicle (EV) production is a universal feature of metazoan cells as well as prokaryotes (bMVs - bacterial microvesicls). They are small vesicles with phospholipid membrane carrying proteins, DNA and different classes of RNAs and are heavily involved in intercellular communication acting as vectors of information to target cells. For the last decade, the interest in EV research has exponentially increased though thorough studies of their roles in various pathologies that was not previously possible due to technical limitations...
June 29, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28663599/palate-perforation-differentiates-cocaine-induced-midline-destructive-lesions-from-granulomatosis-with-polyangiitis
#4
M Trimarchi, S Bondi, E Della Torre, M R Terreni, M Bussi
Cocaine abuse occasionally causes extensive destruction of the osteocartilaginous structures of the nose, sinuses and palate, which mimics the clinical picture of other diseases associated with necrotising midfacial lesions. The differentiation of cocaine-induced midline destructive lesions (CIMDL) and limited granulomatosis with polyangiitis (GPA) may be difficult, particularly if patients do not readily admit substance abuse. We studied 10 patients with CIMDL and palate perforation referred to our Unit between 2002 and 2015...
June 30, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28663399/prediction-of-the-pre-morbid-3d-anatomy-of-the-proximal-humerus-based-on-statistical-shape-modelling
#5
S Poltaretskyi, J Chaoui, M Mayya, C Hamitouche, M J Bercik, P Boileau, G Walch
AIMS: Restoring the pre-morbid anatomy of the proximal humerus is a goal of anatomical shoulder arthroplasty, but reliance is placed on the surgeon's experience and on anatomical estimations. The purpose of this study was to present a novel method, 'Statistical Shape Modelling', which accurately predicts the pre-morbid proximal humeral anatomy and calculates the 3D geometric parameters needed to restore normal anatomy in patients with severe degenerative osteoarthritis or a fracture of the proximal humerus...
July 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28659427/effects-of-increasing-iv-tpa-treated-stroke-mimic-rates-at-ct-based-centers-on-clinical-outcomes
#6
Tina M Burton, Marie Luby, Zurab Nadareishvili, Richard T Benson, John K Lynch, Lawrence L Latour, Amie W Hsia
OBJECTIVE: To determine to what degree stroke mimics skew clinical outcomes and the potential effects of incorrect stroke diagnosis. METHODS: This retrospective analysis of data from 2005 to 2014 included IV tissue plasminogen activator (tPA)-treated adults with clinical suspicion for acute ischemic stroke who were transferred or admitted directly to our 2 hub hospitals. Primary outcome measures compared CT-based spoke hospitals' and MRI-based hub hospitals' mimic rates, hemorrhagic transformation, follow-up modified Rankin Scale (mRS), and discharge disposition...
June 28, 2017: Neurology
https://www.readbyqxmd.com/read/28651553/ig-and-tr-single-chain-fragment-variable-scfv-sequence-analysis-a-new-advanced-functionality-of-imgt-v-quest-and-imgt-highv-quest
#7
Véronique Giudicelli, Patrice Duroux, Sofia Kossida, Marie-Paule Lefranc
BACKGROUND: IMGT®, the international ImMunoGeneTics information system® ( http://www.imgt.org ), was created in 1989 in Montpellier, France (CNRS and Montpellier University) to manage the huge and complex diversity of the antigen receptors, and is at the origin of immunoinformatics, a science at the interface between immunogenetics and bioinformatics. Immunoglobulins (IG) or antibodies and T cell receptors (TR) are managed and described in the IMGT® databases and tools at the level of receptor, chain and domain...
June 26, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28644794/electrocardiogram-signal-quality-assessment-based-on-structural-image-similarity-metric
#8
Yalda Shahriari, Richard Fidler, Michele Pelter, Yong Bai, Andrea Villaroman, Xiao Hu
OBJECTIVE: We developed an image-based electrocardiographic (ECG) quality assessment technique that mimics how clinicians annotate ECG signal quality. METHODS: We adopted the Structural Similarity Measure (SSIM) to compare images of two ECG records that are obtained from displaying ECGs in a standard scale. Then a subset of representative ECG images from the training set was selected as templates through a clustering method. SSIM between each image and all the templates were used as the feature vector for the linear discriminant analysis (LDA) classifier...
June 21, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28641694/-mir-133b-affect-the-proliferation-and-drug-sensitivity-in-a549-lung-cancer-stem-cells-by-targeting-pkm2
#9
Yonghua Mi, Miao He, Beizhong Liu
BACKGROUND: It has been proven that miR-133b could inhibit cancer cell growth, the expression level of miR-133b was significant reduction in lung cancer tissue and serum of patients, and increase the radiation sensitivity of squamous cell carcinoma by targeting PKM2, but the exist mechanisms is not clear. The aim of this study is to explore the effect of miR-133b on proliferation in A549 lung cancer stem cells and drug sensitivity in DDP, and to explore the relationship between miR-133b and PKM2 gene, as well as the effect of cancer stem cells...
June 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28638476/therapeutic-inhibition-of-mir-4260-suppresses-colorectal-cancer-via-targeting-mcc-and-smad4
#10
Junjie Xiao, Dongchao Lv, Jinzhe Zhou, Yihua Bei, Ting Chen, Muren Hu, Qiulian Zhou, Siyi Fu, Qi Huang
Dysregulation of microRNAs (miRNAs, miRs) and their putative target genes have been increasingly reported to contribute to colorectal cancer. However, miRNAs that directly target the mutated in colorectal cancer (MCC) gene, a tumor suppressor which is downregulated or inactivated in colorectal cancer, remain largely unknown. By using an array-based miRNA analysis, we identified a group of miRNAs that were dysregulated in human metastatic versus non-metastatic colorectal cancer tissues. One of these miRNAs, miR-4260, was predicted to target MCC in the miRDB database...
2017: Theranostics
https://www.readbyqxmd.com/read/28630952/estimating-patient-s-health-state-using-latent-structure-inferred-from-clinical-time-series-and-text
#11
Aaron Zalewski, William Long, Alistair E W Johnson, Roger G Mark, Li-Wei H Lehman
Modern intensive care units (ICUs) collect large volumes of data in monitoring critically ill patients. Clinicians in the ICUs face the challenge of interpreting large volumes of high-dimensional data to diagnose and treat patients. In this work, we explore the use of Hierarchical Dirichlet Processes (HDP) as a Bayesian nonparametric framework to infer patients' states of health by combining multiple sources of data. In particular, we employ HDP to combine clinical time series and text from the nursing progress notes in a probabilistic topic modeling framework for patient risk stratification...
February 2017: IEEE-EMBS International Conference on Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28630951/phenotyping-hypotensive-patients-in-critical-care-using-hospital-discharge-summaries
#12
Yang Dai, Sharukh Lokhandwala, William Long, Roger Mark, Li-Wei H Lehman
Among critically-ill patients, hypotension represents a failure in compensatory mechanisms and may lead to organ hypoperfusion and failure. In this work, we adopt a data-driven approach for phenotype discovery and visualization of patient similarity and cohort structure in the intensive care unit (ICU). We used Hierarchical Dirichlet Process (HDP) as a nonparametric topic modeling technique to automatically learn a d-dimensional feature representation of patients that captures the latent "topic" structure of diseases, symptoms, medications, and findings documented in hospital discharge summaries...
February 2017: IEEE-EMBS International Conference on Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28627974/microrna-132-protects-hippocampal-neurons-against-oxygen-glucose-deprivation-induced-apoptosis
#13
Zu-Zhen Sun, Zhan-Yun Lv, Wen-Jing Tian, Yan Yang
Hypoxic-ischemic brain injury (HIBI) results in death or long-term neurologic impairment in both adults and children. In this study, we investigated the effects of microRNA-132 (miR-132) dysregulation on oxygen-glucose deprivation (OGD)-induced apoptosis in fetal rat hippocampal neurons, in order to reveal the therapeutic potential of miR-132 on HIBI. MiR-132 dysregulation was induced prior to OGD exposure by transfection of primary fetal rat hippocampal neurons with miR-132 mimic or miR-132 inhibitor. The effects of miR-132 overexpression and suppression on OGD-stimulated hippocampal neurons were evaluated by detection of cell viability, apoptotic cells rate, and the expression of apoptosis-related proteins...
June 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28613189/cuff-less-blood-pressure-estimation-using-pulse-waveform-analysis-and-pulse-arrival-time
#14
Young-Zoon Yoon, Jae Min Kang, Yongjoo Kwon, Sangyun Park, Seungwoo Noh, Younho Kim, Jongae Park, Sung Woo Hwang
Using the massive MIMIC physiological database, we tried to validate pulse wave analysis (PWA) based on multi-parameters model whether it can continuously estimate blood pressure (BP) values on single site of one hand. In addition, to consider the limitation of insufficient data acquirement for home user, we used pulse arrival time (PAT)-driven BP information to determine the individual scale factors of the PWA-BP estimation model. Experimental results indicate that the accuracy of the average regression model has error standard deviations of 10...
June 12, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28600157/multichannel-sleep-spindle-detection-using-sparse-low-rank-optimization
#15
Ankit Parekh, Ivan W Selesnick, Ricardo S Osorio, Andrew W Varga, David M Rapoport, Indu Ayappa
BACKGROUND: Automated single-channel spindle detectors, for human sleep EEG, are blind to the presence of spindles in other recorded channels unlike visual annotation by a human expert. NEW METHOD: We propose a multichannel spindle detection method that aims to detect global and local spindle activity in human sleep EEG. Using a non-linear signal model, which assumes the input EEG to be the sum of a transient and an oscillatory component, we propose a multichannel transient separation algorithm...
June 25, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28599216/fuzzy-risk-stratification-and-risk-assessment-model-for-clinical-monitoring-in-the-icu
#16
Albion Dervishi
BACKGROUND: The decisions that clinicians make in intensive care units (ICUs) based on monitored parameters reflecting physiological deterioration are of major medical and biomedical engineering interest. These parameters have been investigated and assessed for their usefulness in risk assessment. METHODS: Totally, 127 ICU adult patients were studied. They were selected from a MIMIC II Waveform Database Matched Subset and had continuous monitoring of heart rate, invasive blood pressure, and oxygen saturation...
June 2, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28597703/scoring-model-to-predict-outcome-in-critically-ill-cirrhotic-patients-with-acute-respiratory-failure-comparison-with-meld-scoring-models-and-clif-sofa-score
#17
Xiao-Dong Zhou, Qin-Fen Chen, Ming-Chun Zhang, Sven Van Poucke, Wen-Yue Liu, Yao Lu, Ke-Qing Shi, Wei-Jian Huang, Ming-Hua Zheng
BACKGROUND: Critically ill cirrhotic patients have a high mortality, particularly with concomitant respiratory failure on admission. There are no specific models in use for mortality risk assessment in critically ill cirrhotic patients with acute respiratory failure (CICRF). The aim is to develop a risk prediction model specific to CICRF in order to quantify the severity of illness. METHODS: We analyzed 949 CICRF patients extracted from the MIMIC-III database. The novel model (ARF-CLIF-SOFA) was developed from the CLIF-SOFA score...
June 15, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28582519/x-chromosome-inactivation-in-human-pluripotent-stem-cells-as-a-model-for-human-development-back-to-the-drawing-board
#18
Mieke Geens, Susana M Chuva De Sousa Lopes
BACKGROUND: Human pluripotent stem cells (hPSC), both embryonic and induced (hESC and hiPSC), are regarded as a valuable in vitro model for early human development. In order to fulfil this promise, it is important that these cells mimic as closely as possible the in vivo molecular events, both at the genetic and epigenetic level. One of the most important epigenetic events during early human development is X chromosome inactivation (XCI), the transcriptional silencing of one of the two X chromosomes in female cells...
June 5, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28575144/cernas-in-plants-computational-approaches-and-associated-challenges-for-target-mimic-research
#19
Alexandre Rossi Paschoal, Irma Lozada-Chávez, Douglas Silva Domingues, Peter F Stadler
The competing endogenous RNA hypothesis has gained increasing attention as a potential global regulatory mechanism of microRNAs (miRNAs), and as a powerful tool to predict the function of many noncoding RNAs, including miRNAs themselves. Most studies have been focused on animals, although target mimic (TMs) discovery as well as important computational and experimental advances has been developed in plants over the past decade. Thus, our contribution summarizes recent progresses in computational approaches for research of miRNA:TM interactions...
May 30, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28569652/something-new-about-something-old-a-10-year-follow-up-on-classical-and-new-psychoactive-tryptamines-and-results-of-analysis
#20
Álvaro José Palma-Conesa, Mireia Ventura, Liliana Galindo, Francina Fonseca, Marc Grifell, Pol Quintana, Iván Fornís, Cristina Gil, Magí Farré, Marta Torrens
New psychoactive tryptamines may be a public health risk since they intend to mimic the hallucinogenic effects of regulated psychoactive drugs. Few studies describe uses and clinical effects of unregulated new psychoactive tryptamines. This study aims (1) to explore the presence of tryptamines classified as NPS among the substances delivered for analysis to a harm-reduction organization; (2) to describe the substances found in the samples after analysis; and (3) to compare analytical results of regulated vs...
June 1, 2017: Journal of Psychoactive Drugs
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