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MIMIC database

Shefali Setia Verma, Navya Josyula, Anurag Verma, Xinyuan Zhang, Yogasudha Veturi, Frederick E Dewey, Dustin N Hartzel, Daniel R Lavage, Joe Leader, Marylyn D Ritchie, Sarah A Pendergrass
The DrugBank database consists of ~800 genes that are well characterized drug targets. This list of genes is a useful resource for association testing. For example, loss of function (LOF) genetic variation has the potential to mimic the effect of drugs, and high impact variation in these genes can impact downstream traits. Identifying novel associations between genetic variation in these genes and a range of diseases can also uncover new uses for the drugs that target these genes. Phenome Wide Association Studies (PheWAS) have been successful in identifying genetic associations across hundreds of thousands of diseases...
March 15, 2018: Scientific Reports
Lian Gui, Qianqian Zhang, Yan Cai, Xiaohong Deng, Yingke Zhang, Cheukfai Li, Qi Guo, Xiaoshun He, Junqi Huang
Previous studies have demonstrated that let-7e is associated with inflammatory responses. To date, the roles and mechanisms of let-7e have not been completely revealed. To identify proteins associated with let-7e overexpression and explore their functions in the immune responses, including in cytokine production, we used high-throughput isobaric tag for relative and absolute quantitation (iTRAQ) technology to provide the first genome-wide study of THP-1 cells transfected with let-7e mimic followed by lipopolysaccharide (LPS) stimulation...
March 5, 2018: Proteomics. Clinical Applications
Cheukkai B Hui, Hamidreza Nourzadeh, William T Watkins, Daniel M Trifiletti, Clayton E Alonso, Sunil W Dutta, Jeffrey V Siebers
PURPOSE: To develop a quality assurance (QA) tool that identifies inaccurate organ at risk (OAR) delineations. METHODS: The QA tool computed volumetric features from prior OAR delineation data from 73 thoracic patients to construct a reference database. All volumetric features of the OAR delineation are computed in 3-dimensional space. Volumetric features of a new OAR are compared with respect to those in the reference database to discern delineation outliers. A multi-criteria outlier detection system warns users of specific delineation outliers based on combinations of deviant features...
February 26, 2018: Medical Physics
J Mei, D-H Wang, L-L Wang, Q Chen, L-L Pan, L Xia
OBJECTIVE: To dissect the functioning mode of miR-200c on cervical cancer cell metastasis and growth and provide therapeutic targets for cervical cancer. PATIENTS AND METHODS: By quantitative Real-time polymerase chain reaction, the miR-200c expression level in 42 pairs of cervical cancer tissue samples and six cervical cancer-derived cell lines were examined. Using miR-200c mimics, we analyzed the effects of miR-200c over-expression on cell proliferation, invasion, and migration...
February 2018: European Review for Medical and Pharmacological Sciences
Jessica B Stokes-Parish, Robbert Duvivier, Brian Jolly
BACKGROUND: Simulation Based Education (SBE) is used as a primer for clinical education in nursing and other health professions. Participant engagement strategies and good debriefing have been identified as key for effective simulations. The environment in which the simulation is situated also plays a large role in the degree of participant engagement. Various cues are staged within simulations to enhance this engagement process. Moulage techniques are used in current-day simulation to mimic illnesses and wounds, acting as visual and tactile cues for the learner...
February 15, 2018: Nurse Education Today
Christina Villard, Rebecka Hultgren
OBJECTIVE: Abdominal aortic aneurysm (AAA) predominantly affects an elderly male population. Even so, AAA appears more detrimental in women, who experience a higher risk of aneurysm rupture and a worse outcome after surgery than men. Why women are privileged from yet are worse off once affected has been attributed to an effect of sex hormones. This review summarizes the knowledge of sex differences in AAA and addresses the changes in the aneurysm wall from a gender perspective. METHOD: Standard reporting guidelines set by the PRISMA Group were followed to identify studies examining AAA from a gender perspective...
March 2018: Maturitas
Christopher Jan Schwarzbach, Anne Ebert, Michael G Hennerici, Eva Neumaier-Probst, Michael Platten, Marc Fatar
Background: The safety of systemic thrombolysis in patients with intracranial tumor and cavernoma are unknown. So far evidence is limited to a number of case reports and few case series or unspecified data based on population-based analysis. Our aim was to comprehend the risk of systemic thrombolysis in these patients. Methods: Patients with additional evidence of intracranial tumor or cavernoma who received IV tissue plasminogen activator (t-PA) treatment at our comprehensive stroke center over a period of 7 years were identified in our stroke database and compared to the same number of matched control subjects without any evidence of intracranial tumor and cavernoma...
2018: Therapeutic Advances in Neurological Disorders
Sebastian Gehrmann, Franck Dernoncourt, Yeran Li, Eric T Carlson, Joy T Wu, Jonathan Welt, John Foote, Edward T Moseley, David W Grant, Patrick D Tyler, Leo A Celi
In secondary analysis of electronic health records, a crucial task consists in correctly identifying the patient cohort under investigation. In many cases, the most valuable and relevant information for an accurate classification of medical conditions exist only in clinical narratives. Therefore, it is necessary to use natural language processing (NLP) techniques to extract and evaluate these narratives. The most commonly used approach to this problem relies on extracting a number of clinician-defined medical concepts from text and using machine learning techniques to identify whether a particular patient has a certain condition...
2018: PloS One
Hongshan Yan, Kunxiu Song, Guohui Zhang
Wound healing is a fundamental biological process to restore skin integrity. The role of microRNAs (miRNAs) during this process remains elusive. Thus, our study aimed to investigate the biological functions and its molecular mechanisms of miR-17-3p in cutaneous wound healing. Human keratinocyte cell line HaCaT was transfected with miR-17-3p mimic, antisense oligonucleotides (ASO)-miR-17-3p and corresponding controls respectively. After transfection, MTT, flow cytometry, qRT-PCR and western blot were performed to analyze cell viability, colony-formation and cell cycle...
September 1, 2017: Die Pharmazie
Andrea Schnepf, Daniel Leitner, Magdalena Landl, Guillaume Lobet, Trung Hieu Mai, Shehan Morandage, Cheng Sheng, Mirjam Zörner, Jan Vanderborght, Harry Vereecken
Background and Aims: Root architecture development determines the sites in soil where roots provide input of carbon and take up water and solutes. However, root architecture is difficult to determine experimentally when grown in opaque soil. Thus, root architecture models have been widely used and been further developed into functional-structural models that simulate the fate of water and solutes in the soil-root system. The root architecture model CRootBox presented here is a flexible framework to model root architecture and its interactions with static and dynamic soil environments...
February 8, 2018: Annals of Botany
Yangyang Ding, Xin Ma, Youqing Wang
BACKGROUND AND OBJECTIVES: Intelligent status monitoring for critically ill patients can help medical stuff quickly discover and assess the changes of disease and then make appropriate treatment strategy. However, general-type monitoring model now widely used is difficult to adapt the changes of intensive care unit (ICU) patients' status due to its fixed pattern, and a more robust, efficient and fast monitoring model should be developed to the individual. METHODS: A data-driven learning approach combining locally weighted projection regression (LWPR) and principal component analysis (PCA) is firstly proposed and applied to monitor the nonlinear process of patients' health status in ICU...
March 2018: Computer Methods and Programs in Biomedicine
Anna D Sinaiko, Timothy J Layton, Sherri Rose, Thomas G McGuire
While family purchase of health insurance may benefit insurance markets by pooling individual risk into family groups, the correlation across illness types in families could exacerbate adverse selection. We analyze the impact of family pooling on risk for health insurers to inform policy about family-level insurance plans. Using data on 8,927,918 enrollees in fee-for-service commercial health plans in the 2013 Truven MarketScan database, we compare the distribution of annual individual health spending across four pooling scenarios: (1) "Individual" where there is no pooling into families; (2) "real families" where costs are pooled within families; (3) "random groups" where costs are pooled within randomly generated small groups that mimic families in group size; and (4) "the Sims" where costs are pooled within random small groups which match families in demographics and size...
December 2017: Health Services & Outcomes Research Methodology
Veit Sandfort, Alistair E W Johnson, Lauren M Kunz, Jose D Vargas, Douglas R Rosing
PURPOSE: We sought to evaluate the association of prolonged elevated heart rate (peHR) with survival in acutely ill patients. METHODS: We used a large observational intensive care unit (ICU) database (Multiparameter Intelligent Monitoring in Intensive Care III [MIMIC-III]), where frequent heart rate measurements were available. The peHR was defined as a heart rate >100 beats/min in 11 of 12 consecutive hours. The outcome was survival status at 90 days. We collected heart rates, disease severity (simplified acute physiology scores [SAPS II]), comorbidities (Charlson scores), and International Classification of Diseases (ICD) diagnosis information in 31 513 patients from the MIMIC-III ICU database...
January 1, 2018: Journal of Intensive Care Medicine
Stacy Schantz Wilkins, Paula Bourke, Abdul Salam, Naveed Akhtar, Atlantic D'Souza, Saadat Kamran, Zain Bhutta, Ashfaq Shuaib
OBJECTIVE: Approximately 30% of acute stroke cases are found to be stroke mimics (SM); with functional/psychological stroke mimics (FSM) accounting for up to 6.4% of all stroke presentations. Middle Eastern countries may have higher rates of somatization of emotional distress. The aim of this study was to evaluate the incidence and characteristics of functional SM at a large general hospital in the Middle East. METHODS: All patients presenting with an initial diagnosis of stroke from June 2015 through September 2016 were eligible for this study...
February 1, 2018: Psychosomatic Medicine
Shun-Lai Li, Ying Sui, Jie Sun, Ting-Qi Jiang, Gang Dong
Previous literature exists on the role of microRNA (miR)-132 in initiation and progression of various malignancies. In this study, we aimed at understanding the relationship of miR-132 of prostate tumorigenesis. We collected 32 prostate cancer tissues and adjacent non-cancerous controls, and detected the expression level of miR-132. Then the miRNA database was searched online and luciferase assay perform to understand the regulatory relationship between miR-132 and E2F5. Moreover, we also conducted real-time PCR and western blot analysis to study the mRNA and protein expression level of E2F5 among different groups (cancerous tissue, n=32; non-cancerous tissue, n=32) or cells treated with scramble control, miR-132 mimics, E2F5 siRNA and miR-132 inhibitors...
January 23, 2018: International Journal of Molecular Medicine
Hiroki Nagai, Shogo Hasegawa, Fumihiko Uchida, Takehito Terabe, Naomi Ishibashi Kanno, Koroku Kato, Kenji Yamagata, Satoshi Sakai, Shuichi Kawashiri, Hiroshi Sato, Toru Yanagawa, Hiroki Bukawa
MicroRNAs (miRNAs or miRs) play important roles in carcinogenesis. The miRNA, miR-205-5p, has been reported to suppress the growth of various types of tumor; however, its functional contribution to oral squamous cell carcinoma (OSCC) is not yet clear. Thus, this study was conducted to determine the miRNA expression signatures in OSCC and to investigate the functional role of miR‑205‑5p in OSCC cells. We measured miR‑205‑5p expression by RT-qPCR, and examined the function of miR‑205‑5p by transfecting a miR‑205‑5p mimic or inhibitor into OSCC cells and measuring cell proliferation, migration and invasiveness...
January 31, 2018: International Journal of Oncology
Sebastian Raschka, Anne M Scott, Nan Liu, Santosh Gunturu, Mar Huertas, Weiming Li, Leslie A Kuhn
While the advantage of screening vast databases of molecules to cover greater molecular diversity is often mentioned, in reality, only a few studies have been published demonstrating inhibitor discovery by screening more than a million compounds for features that mimic a known three-dimensional (3D) ligand. Two factors contribute: the general difficulty of discovering potent inhibitors, and the lack of free, user-friendly software to incorporate project-specific knowledge and user hypotheses into 3D ligand-based screening...
January 30, 2018: Journal of Computer-aided Molecular Design
Changwon Park, Sung Wng Kim, Mina Yoon
We introduce a new class of electrides with nontrivial band topology by coupling materials database searches and first-principles-calculations-based analysis. Cs_{3}O and Ba_{3}N are for the first time identified as a new class of electrides, consisting of one-dimensional (1D) nanorod building blocks. Their crystal structures mimic β-TiCl_{3} with the position of anions and cations exchanged. Unlike the weakly coupled nanorods of β-TiCl_{3}, Cs_{3}O and Ba_{3}N retain 1D anionic electrons along the hollow interrod sites; additionally, a strong interrod interaction in C_{3}O and Ba_{3}N induces band inversion in a 2D superatomic triangular lattice, resulting in Dirac-node lines...
January 12, 2018: Physical Review Letters
Eric E Smith, David M Kent, Ketan R Bulsara, Lester Y Leung, Judith H Lichtman, Mathew J Reeves, Amytis Towfighi, William N Whiteley, Darin B Zahuranec
INTRODUCTION: Endovascular thrombectomy is a highly efficacious treatment for large vessel occlusion (LVO). LVO prediction instruments, based on stroke signs and symptoms, have been proposed to identify stroke patients with LVO for rapid transport to endovascular thrombectomy-capable hospitals. This evidence review committee was commissioned by the American Heart Association/American Stroke Association to systematically review evidence for the accuracy of LVO prediction instruments. METHODS: Medline, Embase, and Cochrane databases were searched on October 27, 2016...
January 24, 2018: Stroke; a Journal of Cerebral Circulation
Mohsen Aliakbarian, Fariba Tohidinezhad, Saeid Eslami, Kambiz Akhavan-Rezayat
BACKGROUND: Echinococcosis is a helminthic infection caused by ingestion of the eggs of the parasitic metacestode of one of four members of the Echinococcus genus. Among them, hepatic alveolar echinococcosis (HAE) mimics slow growing liver tumour with subsequent invasion to liver tissues and metastatic dissemination. Liver transplantation (LT) remains as the only treatment option when the lesions exceed the resectability limits. We described the first three cases of HAE who underwent orthotopic LT in Iran...
January 24, 2018: Infectious Diseases
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