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https://www.readbyqxmd.com/read/28109080/microrna-21-inhibits-the-apoptosis-of-osteosarcoma-cell-line-saos-2-via-targeting-caspase-8
#1
Bin Xu, Hehuan Xia, Junming Cao, Zhihong Wang, Yipeng Yang, Yongsheng Lin
Currently, multiple microRNAs (miRNAs) have been found play vital roles in the pathogenesis of osteosarcoma. This studywas aimed to investigate the role of miR-21 in osteosarcoma. The level of miR-21 in 20 pairs of osteosarcoma and correspondingly adjacent tissues were monitored by qPCR. Human osteosarcoma cells line SAOS-2 was transfected with either miR-21 mimic or miR-21 inhibitor, and then cell viability, survival and apoptosis were respectively measured by MTT, colony formation assay, and flow cytometry...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28107173/electronic-cigarettes-and-indoor-air-quality-a-review-of-studies-using-human-volunteers
#2
Najihah Zainol Abidin, Emilia Zainal Abidin, Aziemah Zulkifli, Karmegam Karuppiah, Sharifah Norkhadijah Syed Ismail, Amer Siddiq Amer Nordin
OBJECTIVE: This paper is primarily aimed to review articles on electronic cigarettes (e-cigarettes) focusing on indoor air quality (IAQ) assessment that were conducted using human volunteers under natural settings that mimic actual vaping scenarios. Such studies may give a better representation of the actual potential exposure towards e-cigarettes emissions in indoor settings. METHODS: A systematic literature search was conducted using PubMed search engine database...
January 20, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28099159/reducing-false-arrhythmia-alarm-rates-using-robust-heart-rate-estimation-and-cost-sensitive-support-vector-machines
#3
Qiang Zhang, Xianxiang Chen, Zhen Fang, Qingyuan Zhan, Ting Yang, Shanhong Xia
To lessen the rate of false critical arrhythmia alarms, we used robust heart rate estimation and cost-sensitive support vector machines. The PhysioNet MIMIC II database and the 2015 PhysioNet/CinC Challenge public database were used as the training dataset; the 2015 Challenge hidden dataset was for testing. Each record had an alarm labeled with asystole, extreme bradycardia, extreme tachycardia, ventricular tachycardia or ventricular flutter/fibrillation. Before alarm onsets, 300 s multimodal data was provided, including electrocardiogram, arterial blood pressure and/or photoplethysmogram...
January 18, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28098882/downregulation-of-microrna%C3%A2-34b-is-responsible-for-the-elevation-of-blood-pressure-in-spontaneously-hypertensive-rats
#4
Fan Yang, Haiyu Li, Youyou Du, Qiangwei Shi, Luosha Zhao
The present study aimed to identify the microRNA (miRNA) responsible for the development of primary hypertension, and examine the downstream signaling pathway, which mediates the effect of the miRNA. Reverse transcription‑quantitative polymerase chain reaction analysis was performed to identify which miRNA may be involved in the pathogenesis of hypertension. In silico analysis and a luciferase assay were used to validate the target of the selected miRNA, and miRNA mimics and small interfering (si)RNA of the target were transfected into smooth muscle cells to examine its effect on the biological activity of the cells...
January 16, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28080078/what-to-do-when-scalar-invariance-fails-the-extended-alignment-method-for-multi-group-factor-analysis-comparison-of-latent-means-across-many-groups
#5
Herbert W Marsh, Jiesi Guo, Philip D Parker, Benjamin Nagengast, Tihomir Asparouhov, Bengt Muthén, Theresa Dicke
Scalar invariance is an unachievable ideal that in practice can only be approximated; often using potentially questionable approaches such as partial invariance based on a stepwise selection of parameter estimates with large modification indices. Study 1 demonstrates an extension of the power and flexibility of the alignment approach for comparing latent factor means in large-scale studies (30 OECD countries, 8 factors, 44 items, N = 249,840), for which scalar invariance is typically not supported in the traditional confirmatory factor analysis approach to measurement invariance (CFA-MI)...
January 12, 2017: Psychological Methods
https://www.readbyqxmd.com/read/28064305/upregulation-of-pim2-by-underexpression-of-microrna-135-5p-improves-survival-rates-of-skin-allografts-by-suppressing-apoptosis-of-fibroblast-cells
#6
Hongtu Zhang
BACKGROUND It has been reported that miR-135-5p is involved with many diseases. In this study, we aimed at define the relationship between miR-135-5p level and burn patient survival after skin transplantation. MATERIAL AND METHODS Expression of miR-135-5p and PIM2 was measured using real-time PCR and Western blot analysis in the skin samples collected from burn patients who received skin graft or in the fibroblast cells transfected with miR-135-5p mimics or inhibitors. The regulatory association between miR-135-5p and PIM2 was verified using bioinformatics analysis and luciferase assay...
January 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28063348/the-in-silico-identification-of-small-molecules-for-protein-protein-interaction-inhibition-in-akap-lbc-rhoa-signaling-complex
#7
Asifullah Khan, Mehwish Munir, Sara Aiman, Abdul Wadood, Arif-Ullah Khan
The rational design of small molecules that mimic key residues at the interface of interacting proteins can be a successful approach to target certain biological signaling cascades causing pathophysiological outcome. The A-Kinase Anchoring Protein, i.e. AKAP-Lbc, catalyses nucleotide exchange on RhoA and is involved in cardiac repolarization. The oncogenic AKAP-Lbc induces the RhoA GTPase hyperactivity and aberrantly amplifies the signaling pathway leading to hypertrophic cardiomyocytes. We took advantage of the AKAP-Lbc-RhoA complex crystal structure to design in silico small molecules predicted to inhibit the associated pathological signaling cascade...
December 31, 2016: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28061368/modeling-of-the-photoplethysmogram-during-atrial-fibrillation
#8
Andrius Sološenko, Andrius Petrėnas, Vaidotas Marozas, Leif Sörnmo
A phenomenological model for simulating the photoplethysmogram (PPG) during atrial fibrillation (AF) is proposed. The simulated PPG is solely based on RR interval information, and, therefore, any annotated ECG database can be used to model sinus rhythm, AF, or rhythms with premature beats. A PPG pulse is modeled by a linear combination of a log-normal and two Gaussian waveforms. The model PPG is obtained by placing individual pulses according to the RR intervals so that a connected signal is created. The model is evaluated on synchronously recorded ECG and PPG signals from the MIMIC and the University of Queensland Vital Signs Dataset databases...
December 28, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28057571/acyl-chain-preference-and-inhibitor-identification-of-moraxella-catarrhalis-lpxa-insight-through-crystal-structure-and-computational-studies
#9
Shivendra Pratap, Pooja Kesari, Ravi Yadav, Aditya Dev, Manju Narwal, Pravindra Kumar
Lipopolysaccharide (LPS) is an important surface component and a potential virulence factor in the pathogenesis of Gram-negative bacteria. UDP-N-acetylglucosamine acyltransferase (LpxA) enzyme catalyzes the first reaction of LPS biosynthesis, reversible transfer of R-3-hydroxy-acyl moiety from donor R-3-hydroxy-acyl-acyl carrier protein to the 3' hydroxyl position of UDP-N-acetyl-glucosamine. LpxA enzyme's essentiality in bacterial survival and absence of any homologous protein in humans makes it a promising target for anti-bacterial drug development...
January 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28053301/what-is-the-main-potential-factor-influencing-ocular-protrusion
#10
Yinwei Li, Yun Su, Xuefei Song, Huifang Zhou, Xianqun Fan
BACKGROUND The aim of the present study was to establish the normal-range orbital parameters and to explore the relationships between ocular protrusion and various orbital morphological factors. MATERIAL AND METHODS A retrospective, non-comparative case series was conducted from January 2014 to December 2015. We recruited 56 subjects (112 orbits), including 27 males (21 to 87 years of age) and 29 females (22 to 88 years of age) in this study. Nine length measurements, 2 angle measurements, and 2 volume measurements of various aspects of the orbit were obtained using Mimics v18...
January 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28053167/pcerbase-a-database-of-plant-competing-endogenous-rna
#11
Chunhui Yuan, Xianwen Meng, Xue Li, Nicola Illing, Robert A Ingle, Jingjing Wang, Ming Chen
Competition for microRNA (miRNA) binding between RNA molecules has emerged as a novel mechanism for the regulation of eukaryotic gene expression. Competing endogenous RNA (ceRNA) can act as decoys for miRNA binding, thereby forming a ceRNA network by regulating the abundance of other RNA transcripts which share the same or similar microRNA response elements. Although this type of RNA cross talk was first described in Arabidopsis, and was subsequently shown to be active in animal models, there is no database collecting potential ceRNA data for plants...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28043639/identification-of-novel-mycobacterium-tuberculosis-dihydrofolate-reductase-inhibitors-through-rational-drug-design
#12
Mymoona Akhter
OBJECTIVES/BACKGROUND: Dihydrofolate reductase (DHFR) is one of the validated drug targets in Mycobacterium tuberculosis (Mtb) infection. DHFR inhibitors have been used to treat various life-threatening diseases such as cancer, malaria, and several bacterial infections. However, all clinically effective DHFR inhibitors are non-selective, and inhibit both human and pathogenic DHFRs more or less to a similar extent. The crystal structure of various DHFRs complexed with nicotinamide adenine dinucleotide phosphate and different inhibitors is available in the protein data bank...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28040687/de-identification-of-patient-notes-with-recurrent-neural-networks
#13
Franck Dernoncourt, Ji Young Lee, Ozlem Uzuner, Peter Szolovits
OBJECTIVE: Patient notes in electronic health records (EHRs) may contain critical information for medical investigations. However, the vast majority of medical investigators can only access de-identified notes, in order to protect the confidentiality of patients. In the United States, the Health Insurance Portability and Accountability Act (HIPAA) defines 18 types of protected health information that needs to be removed to de-identify patient notes. Manual de-identification is impractical given the size of electronic health record databases, the limited number of researchers with access to non-de-identified notes, and the frequent mistakes of human annotators...
December 30, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28013316/inhibition-of-microrna-149-5p-induces-apoptosis-of-acute-myeloid-leukemia-cell-line-thp-1-by-targeting-fas-ligand-faslg
#14
Peijun Tian, Li Yan
BACKGROUND This study was aimed to reveal the role of miR-149-5p in acute myeloid leukemia (AML) cells apoptosis and the possible mechanism involved. MATERIAL AND METHODS The expression of miR-149-5p in leukemia cell lines, as well as the blood and bone marrow (BM) samples from leukemia patients, were monitored by reverse-transcription polymerase chain reaction (RT-PCR). AML cell line THP-1 was transfected with miR-149-5p mimic or inhibitor, and then cell apoptosis was determined using the APO Percentage assay kit...
December 25, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28011203/small-molecule-mimics-of-dftamp1-a-database-designed-anti-staphylococcal-peptide
#15
Yuxiang Dong, Tamara Lushnikova, Radha M Golla, Xiaofang Wang, Guangshun Wang
Antimicrobial peptides (AMPs) are important templates for developing new antimicrobial agents. Previously, we developed a database filtering technology that enabled us to design a potent anti-Staphylococcal peptide DFTamP1. Using this same design approach, we now report the discovery of a new class of bis-indole diimidazolines as AMP small molecule mimics. The best compound killed multiple S. aureus clinical strains in both planktonic and biofilm forms. The compound appeared to target bacterial membranes with antimicrobial activity and membrane permeation ability similar to daptomycin...
November 30, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27938360/overweight-and-obesity-epidemic-in-ghana-a-systematic-review-and-meta-analysis
#16
Richard Ofori-Asenso, Akosua Adom Agyeman, Amos Laar, Daniel Boateng
BACKGROUND: In many low and middle income countries (LMICs), the distribution of adulthood nutritional imbalance is shifting from a predominance of undernutrition to overnutrition. This complex problem poses a huge challenge to governments, non-state actors, and individuals desirous of addressing the problem of malnutrition in LMICs. The objective of this study was to systematically review the literature towards providing an estimate of the prevalence of overweight and obesity among adult Ghanaians...
December 9, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27936097/petmbase-a-database-of-plant-endogenous-target-mimics-etms
#17
Gökhan Karakülah, Kuaybe Yücebilgili Kurtoğlu, Turgay Unver
MicroRNAs (miRNA) are small endogenous RNA molecules, which regulate target gene expression at post-transcriptional level. Besides, miRNA activity can be controlled by a newly discovered regulatory mechanism called endogenous target mimicry (eTM). In target mimicry, eTMs bind to the corresponding miRNAs to block the binding of specific transcript leading to increase mRNA expression. Thus, miRNA-eTM-target-mRNA regulation modules involving a wide range of biological processes; an increasing need for a comprehensive eTM database arose...
2016: PloS One
https://www.readbyqxmd.com/read/27932670/annals-express-red-blood-cell-distribution-width-and-neutrophil-to-lymphocyte-ratio-are-associated-with-outcomes-of-adult-subarachnoid-hemorrhage-patients-admitted-to-intensive-care-unit
#18
Yuan-Lan Huang, Zhi-Jun Han, Zhi-De Hu
BACKGROUND: Red blood cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) have been reported to be associated with outcomes of acute cerebral infarction. However, their prognostic value in patients with subarachnoid hemorrhage (SAH) remains largely unknown. The aim of this study was to investigate the prognostic value of RDW and NLR in SAH patients. METHODS: Medical records of adult SAH patients admitted to intensive care unit (ICU) were extracted from Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II, version 2...
December 8, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27923017/expression-of-microrna-328-functions-as-a-biomarker-for-recurrence-of-early-gastric-cancer-egc-after-endoscopic-submucosal-dissection-esd-by-modulating-cd44
#19
Hui-Guang Xue, Ai-Hua Yang, Xue-Guo Sun, Yan-Yan Lu, Zi-Bin Tian
BACKGROUND This study investigated the molecular mechanism of the effect of CD44 on the recurrence of EGC after ESD, including the potential regulator and signaling pathways of CD44. MATERIAL AND METHODS We searched the miRNA online database (www.mirdb.org) with the "seed sequence" located within the 3'-UTR of the target gene, and performed luciferase assay to test the miRNA/mRNA relationship. We also determined the expression of CD44 in the EGC and control samples. In addition, statistical analysis was used to explore the role of miR-328 as a biomarker to predict the recurrence after ECD...
December 6, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27913053/intestinal-metaplasia-of-appendiceal-endometriosis-is-not-uncommon-and-may-mimic-appendiceal-mucinous-neoplasm
#20
Monika Vyas, Serena Wong, Xuchen Zhang
Endometriosis of the appendix can be an incidental finding or a cause of appendicitis, intussusception, perforation or retention mucocele. Intestinal metaplasia of appendiceal endometriosis may occur, which can lead to a misdiagnosis of low-grade appendiceal mucinous neoplasm. On a retrospective search of the pathology database from 2001 to 2015, we identified 78 appendiceal endometriosis cases and intestinal metaplasia was present in 10/78 (13%) cases. In most of the cases (90%), the foci of intestinal metaplasia were mainly localized close to the mucosa...
January 2017: Pathology, Research and Practice
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