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https://www.readbyqxmd.com/read/28537742/correlating-the-para-substituent-effects-on-ru-ii-polypyridine-photophysical-properties-and-on-the-corresponding-hybrid-p450-bm3-enzymes-photocatalytic-activity
#1
Hadil Shalan, Alexander Colbert, Thanh Truc Nguyen, Mallory Kato, Lionel Cheruzel
Ru(II)-diimine complexes covalently attached near the heme active site of P450 BM3 enzymes have been used to rapidly inject electrons and drive selective C-H functionalization upon visible light irradiation. Herein, we have generated a series of hybrid P450 BM3 enzymes containing a photosensitizer of general formula [Ru(4,4'-X2bpy)2(PhenA)](2+) where X = Cl, H, tBu, Me OPhe, OMe, or NMe2, bpy = 2,2'-bipyridine, and PhenA = 5-acetamido-1,10-phenanthroline. We then probed the effect of electron-withdrawing and -donating groups at the para position of the 4,4'-X2bpy ligands on the corresponding hybrid enzymes photocatalytic activity...
May 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28534051/cooling-strategies-for-brazilian-flounder-paralichthys-orbignyanus-embryos
#2
A S Varela, T F Cardoso, E Fernandes E Silva, K L Goularte, M H Okamoto, L A Sampaio, R D Jardim, C D Corcini
BACKGROUND: Paralichthys orbignyanus is the species of the greatest potential for marine and estuarine fish farming in southern Brazil. Consequently, embryo cryopreservation becomes an important tool for increasing their production. OBJECTIVE: To evaluate the effects of cooling protocols on the viability of embryos of P. orbignyanus at two stages of development (neurula and early differentiation of the tail). MATERIALS AND METHODS: Control embryos were maintained at 23 degree C and treated embryos were cooled to 15 degree C, 10 degree C and 5 degree C at rapid, moderate and slow cooling rates...
March 2017: Cryo Letters
https://www.readbyqxmd.com/read/28533590/characteristics-of-patients-with-hemiparetic-stroke-who-yield-highly-reliable-muscle-strength-measurements
#3
Ken Tomida, Genichi Tanino, Shinya Sasaki, Akira Suzuki, Sayaka Okamoto, Shigeru Sonoda
[Purpose] Accurate measurement of unaffected lower extremity muscle strength on the unaffected side is useful in patients with hemiparetic stroke; however, muscle strength measurement results in patients with hemiparetic stroke vary greatly compared with those in healthy individuals. The objective of the present study was to determine the characteristics of patients with hemiparetic stroke who yield highly reliable muscle strength measurements. [Subjects and Methods] The subjects were 55 incipient patients with hemiparetic stroke...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28529889/a-surviving-24-month-old-patient-with-neonatal-onset-carnitine-palmitoyltransferase-ii-deficiency
#4
Naohiro Ikeda, Shinsuke Maruyama, Kanna Nakano, Ryo Imakiire, Yumiko Ninomiya, Shunji Seki, Kosuke Yanagimoto, Yasuyuki Kakihana, Keiichi Hara, Go Tajima, Yasuhiro Okamoto, Yoshifumi Kawano
The early-onset form of carnitine palmitoyltransferase (CPT) II deficiency has severe outcomes; patients typically die during the newborn period. We report a case of neonatal-onset CPT II deficiency with prolonged survival, exceeding 24 months. The patient was successfully treated by continuous hemodialysis (CHD), which enabled her to overcome repeated crises. We suggest that early intensive treatment, including CHD, is a key for prolonged survival in patients with neonatal-onset CPT II deficiency.
June 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28529750/phase-i-study-of-weekly-palliative-chemotherapy-with-low-dose-third-line-paclitaxel-for-biliary-tract-cancer
#5
Hidehiro Tajima, Tetsuo Ohta, Hiroyuki Shinbashi, Atsushi Hirose, Mitsuyoshi Okazaki, Takahisa Yamaguchi, Yoshinao Ohbatake, Koichi Okamoto, Shinichi Nakanuma, Seisho Sakai, Jun Kinoshita, Isamu Makino, Keishi Nakamura, Hironori Hayashi, Katsunobu Oyama, Masafumi Inokuchi, Tomoharu Miyashita, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Hiroyuki Nakamura
The prognosis of patients with unresectable and recurrent biliary tract cancer (BTC) is very poor. Although gemcitabine (GEM) plus cisplatin therapy is useful for unresectable cases, the median overall survival (OS) of the patients is <1 year, and third-line chemotherapy following failure of 5-fluorouracil (5-FU) and GEM plus cisplatin is currently unavailable. The clinical efficacy and basic effects of low-dose paclitaxel (PTX) therapy for patients with BTC was previously reported. We herein present the results of a phase I clinical trial of weekly low-dose PTX as third-line palliative chemotherapy...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28529263/depressive-status-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#6
Sayaka Funabashi, Masaharu Kataoka, Takumi Inami, Toshiaki Kikuchi, Ryoji Yanagisawa, Chikako Ishiguro, Susumu Okamoto, Hideaki Yoshino, Koichiro Watanabe, Toru Satoh
BACKGROUND: The present comparative study with healthy volunteers was conducted to investigate the depressive status and temperament in patients with chronic thromboembolic pulmonary hypertension (CTEPH).Methods and Results:The results of the temperament and personality scale test, and the Quick Inventory of Depressive Symptomatology-Self Report revealed that CTEPH patients have a significantly higher depressive status than healthy volunteers. CONCLUSIONS: It may be that CTEPH patients are more likely to have a depressive temperament in origin...
May 20, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28529140/magnesium-attenuates-cisplatin-induced-nephrotoxicity-by-regulating-the-expression-of-renal-transporters
#7
Yoshitaka Saito, Keisuke Okamoto, Masaki Kobayashi, Katsuya Narumi, Takehiro Yamada, Ken Iseki
Cisplatin (CDDP)-induced nephrotoxicity (CIN) is one of the most serious toxicities caused by this potent antitumor agent. It has been reported that Mg premedication attenuates CIN in clinical trials; however, the mechanism underlying its nephroprotection is not fully understood. Therefore, the aim of this study was to determine whether Mg administration affects CDDP accumulation by regulating the expression level of renal transporters. Rats were divided into control, Mg (40mg/kg) alone, 2.5mg/kg CDDP with (20 and 40mg/kg) and without Mg, 5mg/kg CDDP groups...
May 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28528898/corrigendum-to-modelling-urea-cycle-disorder-citrullinemia-type-1-with-disease-specific-ipscs-biochem-biophys-res-commun-486-3-2017-613-619
#8
Elena Yukie Yoshitoshi-Uebayashi, Taro Toyoda, Katsutaro Yasuda, Maki Kotaka, Keiko Nomoto, Keisuke Okita, Kentaro Yasuchika, Shinya Okamoto, Noriyuki Takubo, Toshiya Nishikubo, Tomoyoshi Soga, Shinji Uemoto, Kenji Osafune
No abstract text is available yet for this article.
May 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28522225/genetic-screening-of-spinal-muscular-atrophy-using-a-real-time-modified-cop-pcr-technique-with-dried-blood-spot-dna
#9
Mawaddah Ar Rochmah, Nur Imma Fatimah Harahap, Emma Tabe Eko Niba, Kenta Nakanishi, Hiroyuki Awano, Ichiro Morioka, Kazumoto Iijima, Toshio Saito, Kayoko Saito, Poh San Lai, Yasuhiro Takeshima, Atsuko Takeuchi, Yoshihiro Bouike, Maya Okamoto, Hisahide Nishio, Masakazu Shinohara
BACKGROUND: Spinal muscular atrophy (SMA) is a common neuromuscular disorder caused by mutations in SMN1. More than 95% of SMA patients carry homozygous SMN1 deletion. SMA is the leading genetic cause of infant death, and has been considered an incurable disease. However, a recent clinical trial with an antisense oligonucleotide drug has shown encouraging clinical efficacy. Thus, early and accurate detection of SMN1 deletion may improve prognosis of many infantile SMA patients. METHODS: A total of 88 DNA samples (37 SMA patients, 12 carriers and 39 controls) from dried blood spots (DBS) on filter paper were analyzed...
May 15, 2017: Brain & Development
https://www.readbyqxmd.com/read/28521269/a-new-technique-for-dorsal-sural-nerve-conduction-study-with-surface-strip-electrodes
#10
Shoji Hemmi, Katsumi Kurokawa, Taiji Nagai, Ryutaro Kushida, Toshio Okamoto, Tatsufumi Murakami, Yoshihide Sunada
OBJECTIVE: To obtain higher amplitude of dorsal sural sensory nerve action potentials (SNAPs), we used a new method for dorsal sural nerve conduction study with surface strip electrodes (SSEs). METHODS: Dorsal sural SNAPs were recorded orthodromically. The recording electrodes were placed behind the lateral malleolus. SSEs were attached to the laterodorsal aspect of the foot for stimulation of the dorsal sural nerve (DSN). We also used a conventional method with a standard bipolar stimulator and compared the findings...
April 19, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28516497/total-synthesis-of-o-galnacylated-antifreeze-glycoprotein-using-the-switchable-reactivity-of-peptidyl-n-pivaloylguanidine
#11
Ryo Orii, Noriko Sakamoto, Daichi Fukami, Sakae Tsuda, Masayuki Izumi, Yasuhiro Kajihara, Ryo Okamoto
Antifreeze glycoprotein (AFGP) is an O-glycoprotein that displays antifreeze activity through depression of the freezing point of water. GalNAc is a core sugar structure of AFGP, and contributes to induce antifreeze activity of this glycoprotein. However the general functional role that this sugar plays at the molecular level is still unknown. To elucidate this, it is essential to determine the relationship between structure and activity of O-GalNAcylated AFGP using homogeneous glycoproteins. We thus conducted total synthesis of homogeneous O-GalNAcylated AFGP by using a unique peptide derivative: peptidyl-N-pivaloylguanidine...
May 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28516402/effects-of-calcineurin-inhibitors-on-sodium-excretion-in-recipients-of-allogeneic-hematopoietic-stem-cell-transplantation
#12
Masuho Saburi, Sumiko Kohashi, Jun Kato, Yuya Koda, Masatoshi Sakurai, Takaaki Toyama, Taku Kikuchi, Daiki Karigane, Sayako Yuda, Yusuke Yamane, Risa Hashida, Ryohei Abe, Tomonori Nakazato, Junichi Hirahashi, Masao Ogata, Shinichiro Okamoto, Takehiko Mori
Calcineurin inhibitors (CIs) such as cyclosporine A (CSA) and tacrolimus often cause renal dysfunction, resulting in increased serum creatinine, hyperkalemia, and hyperuricemia. However, the effects of CIs on sodium excretion have not been fully elucidated. We retrospectively evaluated the effects of CI administration on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation (HSCT). Fifty consecutive recipients each of allogeneic HSCT receiving either CSA or tacrolimus (100 patients in total) with available data for weekly fractional excretion of sodium (FENa) for a 4-week period after transplantation were enrolled in this retrospective analysis...
May 17, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28515929/clinical-outcome-of-posterior-fixation-surgery-in-patients-with-vertebral-metastasis-of-lung-cancer
#13
Tomoyuki Igarashi, Keigo Okamoto, Koji Teramoto, Ryosuke Kaku, Keiko Ishida, Keiko Ueda, Yo Kawaguchi, Tetsuo Hori, Masayuki Hashimoto, Shoji Kitamura, Noriaki Tezuka, Jun Hanaoka
Vertebral metastasis of non-small-cell lung cancer (NSCLC) often leads to neurological paralysis, with deterioration of the patients' activities of daily living (ADL). Surgical treatments for the symptoms are unlikely to be recommended due to the poor prognosis of patients with advanced NSCLC. The aim of the present study was to retrospectively evaluate the clinical outcome of posterior spinal fixation surgery in patients with neurological paralysis resulting from vertebral metastasis of NSCLC. Between April, 2007 and March, 2012, 4 patients (3 men and 1 woman; median age, 56...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28515470/a-novel-missense-mutation-in-the-hect-domain-of-nedd4l-identified-in-a-girl-with-periventricular-nodular-heterotopia-polymicrogyria-and-cleft-palate
#14
Koji Kato, Fuyuki Miya, Ikumi Hori, Daisuke Ieda, Kei Ohashi, Yutaka Negishi, Ayako Hattori, Nobuhiko Okamoto, Mitsuhiro Kato, Tatsuhiko Tsunoda, Mami Yamasaki, Yonehiro Kanemura, Kenjiro Kosaki, Shinji Saitoh
We identified a novel de novo heterozygous missense mutation in the NEDD4L gene (NM_015277: c.2617G>A; p.Glu873Lys) through whole-exome sequencing in a 3-year-old girl showing severe global developmental delay, infantile spasms, cleft palate, periventricular nodular heterotopia and polymicrogyria. Mutations in the HECT domain of NEDD4L have been reported in patients with a neurodevelopmental disorder along with similar brain malformations. All patients reported with NEDD4L HECT domain mutations showed periventricular nodular heterotopia, and most had seizures, cortex anomalies, cleft palate and syndactyly...
May 18, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28515152/effects-of-deficiency-of-kelch-like-ech-associated-protein-1-on-skeletal-organization-a-mechanism-for-diminished-nuclear-factor-of-activated-t-cells-cytoplasmic-1-during-osteoclastogenesis
#15
Eiko Sakai, Masanobu Morita, Masahiro Ohuchi, Mizuho A Kido, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Ken Itoh, Masayuki Yamamoto, Takayuki Tsukuba
Kelch-like ECH-associated protein 1 (Keap1) binds to nuclear factor E2 p45-related factor 2 (Nrf2), a transcription factor for antioxidant enzymes, to suppress Nrf2 activation. The role of oxidative stress in many diseases supports the possibility that processes that are associated with Nrf2 activation might offer therapeutic potential. Nrf2 deficiency induces osteoclastogenesis, which is responsible for bone loss, by activating receptor activator of NF-κB ligand (RANKL)-mediated signaling; however, the effects of Keap1 deficiency remain unclear...
May 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28513662/chemical-synthesis-of-dual-labeled-proteins-via-differently-protected-alkynes-enables-intramolecular-fret-analysis
#16
Gosuke Hayashi, Naoki Kamo, Akimitsu Okamoto
We report a novel method for multisite protein conjugation by setting differently silyl-protected alkynes as conjugation handles, which can remain intact through the whole synthetic procedure and provide sequential and orthogonal conjugation. This strategy enables efficient preparation of a dual dye-labeled protein and structural analysis via an intramolecular FRET mechanism.
May 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28512572/experimental-strategies-for-imaging-bioparticles-with-femtosecond-hard-x-ray-pulses
#17
Benedikt J Daurer, Kenta Okamoto, Johan Bielecki, Filipe R N C Maia, Kerstin Mühlig, M Marvin Seibert, Max F Hantke, Carl Nettelblad, W Henry Benner, Martin Svenda, Nicuşor Tîmneanu, Tomas Ekeberg, N Duane Loh, Alberto Pietrini, Alessandro Zani, Asawari D Rath, Daniel Westphal, Richard A Kirian, Salah Awel, Max O Wiedorn, Gijs van der Schot, Gunilla H Carlsson, Dirk Hasse, Jonas A Sellberg, Anton Barty, Jakob Andreasson, Sébastien Boutet, Garth Williams, Jason Koglin, Inger Andersson, Janos Hajdu, Daniel S D Larsson
This study explores the capabilities of the Coherent X-ray Imaging Instrument at the Linac Coherent Light Source to image small biological samples. The weak signal from small samples puts a significant demand on the experiment. Aerosolized Omono River virus particles of ∼40 nm in diameter were injected into the submicrometre X-ray focus at a reduced pressure. Diffraction patterns were recorded on two area detectors. The statistical nature of the measurements from many individual particles provided information about the intensity profile of the X-ray beam, phase variations in the wavefront and the size distribution of the injected particles...
May 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28511180/response-predictors-of-s-1-cisplatin-and-docetaxel-combination-chemotherapy-for-metastatic-gastric-cancer-microarray-analysis-of-whole-human-genes
#18
Shinji Kitamura, Toshihito Tanahashi, Eriko Aoyagi, Tadahiko Nakagawa, Koichi Okamoto, Tetsuo Kimura, Hiroshi Miyamoto, Yasuhiro Mitsui, Kazuhito Rokutan, Naoki Muguruma, Tetsuji Takayama
OBJECTIVES: The aim of this study was to identify biomarkers for predicting the efficacy of docetaxel, cisplatin, and S-1 (DCS) therapy for advanced gastric cancer using microarrays of biopsy specimens before chemotherapy. METHODS: Nineteen samples were taken from 19 patients with unresectable metastatic gastric cancer who received DCS as a first-line therapy. Laser capture microdissection was performed, and total cellular RNA was extracted from each microdissected sample...
May 17, 2017: Oncology
https://www.readbyqxmd.com/read/28509131/growth-hormone-therapy-for-a-patient-with-idiopathic-fanconi-syndrome-and-growth-hormone-deficiency
#19
Takayuki Okamoto, Yasuyuki Sato, Takeshi Yamazaki, Asako Hayashi, Toshiyuki Takahashi
Idiopathic Fanconi syndrome (FS) is characterized by a generalized dysfunction of the renal proximal tubules. Patients with FS often exhibit growth retardation due to complex factors, such as hypophosphatemia, metabolic acidosis, disturbed vitamin D metabolism and hypokalemia. To date, one FS patient has been reported to exhibit growth failure due to growth hormone deficiency (GHD), but the long-term clinical course of recombinant human GH (rhGH) therapy has not been reported. At 10 months of age, the patient was admitted to our hospital due to growth failure...
May 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28505533/discovery-and-characterization-of-selective-human-sphingomyelin-synthase-2-inhibitors
#20
Ryutaro Adachi, Kazumasa Ogawa, Shin-Ichi Matsumoto, Takuya Satou, Yukiya Tanaka, Jyunichi Sakamoto, Takashi Nakahata, Rei Okamoto, Masahiro Kamaura, Tomohiro Kawamoto
Sphingomyelin synthase (SMS) is a membrane enzyme that catalyzes the synthesis of sphingomyelin, is required for the maintenance of plasma membrane microdomain fluidity, and has two isoforms: SMS1 and SMS2. Although these isoforms exhibit the same SMS activity, they are different enzymes with distinguishable subcellular localizations. It was reported that SMS2 KO mice displayed lower inflammatory responses and anti-atherosclerotic effects, suggesting that inhibition of SMS2 would be a potential therapeutic approach for controlling inflammatory responses and atherosclerosis...
April 25, 2017: European Journal of Medicinal Chemistry
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