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malignant large bowel obstruction

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https://www.readbyqxmd.com/read/29235008/oncological-assessment-of-stent-placement-for-obstructive-colorectal-cancer-from-circulating-cell-free-dna-and-circulating-tumor-dna-dynamics
#1
Goro Takahashi, Takeshi Yamada, Takuma Iwai, Kohki Takeda, Michihiro Koizumi, Seiichi Shinji, Eiji Uchida
BACKGROUND: The self-expanding metallic stent (SEMS) provides effective decompression for patients with malignant large bowel obstruction (MLBO); however, mechanical damage to malignant cells from insertion may negatively affect prognosis, similar to surgical manipulation, and its oncological safety is unclear. We examined mechanical damage from SEMS placement using circulating cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA). METHODS: Between 1 November 2014 and 30 June 2017, 35 MLBO patients were analyzed, comprising 25 SEMS patients and 10 transanal decompression tube (TDT) patients (control)...
December 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29198676/case-report-primary-de-novo-sarcoma-in-transplant-pancreas-allograft
#2
S Nagaraju, S J Grethlein, S Vaishnav, A A Sharfuddin, J A Powelson, J A Fridell
BACKGROUND: The majority of malignancies after transplantation appear to be virally mediated and of recipient origin. Donor-derived neoplasms occur early, whereas recipient-origin tumors typically occur many years after transplantation. Sarcomas are a relatively rare form of cancer. The etiology of sarcomas remains largely unknown, although some are linked to viruses, familial cancer syndromes, or therapeutic radiation exposure. Primary sarcomas are extremely rare, accounting for <0...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29197194/the-role-of-self-expandable-metallic-stents-as-bridge-to-surgery-for-the-treatment-of-acute-malignant-colorectal-obstruction-our-experience
#3
Gianpasquale Gallo, Giuseppe Sammarco, Alessandro Paolo Chiriatti, Ferdinando Calabria, Rosario Sacco
INTRODUCTION: Despite the widespread use of screening programs, the colorectal cancer occurs in 7-29% of cases with a bowel obstruction, needing an immediate decompression treatment by emergency surgery; unfortunately, the emergency surgery is characterized by high morbidity and mortality rates. The endoscopic placement of self-expandable metallic stents can be a useful alternative, allowing to decompress the acute obstruction in a short time, in order to correct dehydration, electrolytic imbalance and to improve the overall clinical conditions prior to adequately plan the intervention of elective surgery...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29122616/practice-patterns-of-medications-for-patients-with-malignant-bowel-obstruction-using-a-nationwide-claims-database-and-the-association-between-treatment-outcomes-and-concomitant-use-of-h2-blockers-proton-pump-inhibitors-and-corticosteroids-with-octreotide
#4
Takaaki Minoura, Masato Takeuchi, Tatsuya Morita, Koji Kawakami
CONTEXT: Malignant bowel obstruction (MBO) impairs the quality of life in patients with advanced cancer. Octreotide, acid-suppressing medications such as H<sub>(2)</sub>-receptor antagonists (H<sub>(2)</sub> blockers) and proton pump inhibitors (PPIs), and corticosteroids are often used in combination for symptom control. OBJECTIVES: We evaluated the practice patterns of medications for patients hospitalized with MBO using a large claims database in Japan...
November 6, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29118874/pharmacobezoar-an-unusual-cause-of-large-bowel-obstruction
#5
Rishitha Yelisetti, Areig Awad, Bushra Ambreen, Ritika Zijoo, Sara Wallach
Large bowel obstruction (LBO) is an abdominal emergency with high morbidity and mortality rates if left untreated. LBO is four to five times less frequent than small bowel obstruction (SBO) and the causes of LBO and SBO differ substantially. Colonic malignancy remains the most common cause of LBO (> 60%). Additional causes of LBO include entities such as diverticulitis, colonic volvulus, and adhesion. Herein we present a case of acute LBO caused by pharmacobezoar.
October 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29091349/randomised-controlled-trial-of-colonic-stent-insertion-in-non-curable-large-bowel-obstruction-a-post-hoc-cost-analysis
#6
Christopher J Young, Assad Zahid
AIM: With the increasing burden on the health care system, this study aims to perform a cost-effectiveness analysis on the management of incurable large bowel obstruction comparing the cost of a stent versus surgery. METHOD: A prospective randomised controlled trial was conducted at two major teaching hospitals in Australia between September 2006 and November 2011. 56 patients with malignant incurable large bowel obstruction were randomised to stent insertion or surgical decompression, of whom 52 were included in the final analysis...
November 1, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28892247/short-term-results-of-self-expanding-metal-stents-for-acute-malignant-large-bowel-obstruction
#7
M Kobborg, M Broholm, E Frostberg, M Jeppesen, I Gögenür
AIM: Self-expanding metal stents (SEMSs) can be used as a palliative treatment or to initially decompress colon prior to definitive surgery (as a so-called 'bridge to surgery'). The purpose of this study was to investigate the efficacy and safety of SEMS used as palliation and bridge to surgery for malignant large bowel obstruction. METHOD: A multicentre retrospective study was conducted from January 2010 to December 2013 to identify patients undergoing stent placement for acute large bowel obstruction...
October 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28798242/a-rare-urological-presentation-of-appendicitis
#8
Nick Simson, Thomas Stonier, Alberto Coscione, Ahmed Qteishat
A 17-year-old boy with no medical comorbidities, but a significant family history of malignancy, presented to Accident and Emergency following 3 days of increasing rectal pain, symptoms of bladder outflow obstruction (poor flow, intermittent stream and hesitancy) and dysuria. Notably he had no abdominal pain. Digital rectal examination revealed a tender, enlarged prostate. Inflammatory markers were significantly raised (white cell count 17.7, C reactive protein 191). He was diagnosed clinically as prostatitis and commenced on intravenous antibiotics...
August 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28761765/endoscopic-stenting-as-bridge-to-surgery-versus-emergency-resection-for-left-sided-malignant-colorectal-obstruction-an-updated-meta-analysis
#9
REVIEW
Niccolò Allievi, Marco Ceresoli, Paola Fugazzola, Giulia Montori, Federico Coccolini, Luca Ansaloni
INTRODUCTION: Emergency resection represents the traditional treatment for left-sided malignant obstruction. However, the placement of self-expanding metallic stents and delayed surgery has been proposed as an alternative approach. The aim of the current meta-analysis was to review the available evidence, with particular interest for the short-term outcomes, including a recent multicentre RCT. METHODS: We considered randomized controlled trials comparing stenting as a bridge to surgery and emergency surgery for the management of left-sided malignant large bowel obstruction, performing a systematic review in MEDLINE, PubMed database, and the Cochrane libraries...
2017: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28569279/safety-and-efficacy-of-self-expandable-metal-stents-for-obstructive-proximal-and-distal-large-bowel-cancer
#10
V Mitra, M Hu, D Majumdar, V Krishnan, B Chaudhury, J Hancock, D Dwarakanath
Self-expandable metal stents are often used to treat obstructive large bowel cancers. This study assessed the safety and efficacy of colonic stent insertion carried out in a district general hospital. Methods A retrospective review was carried out between 1 January 2007 and 28 February 2014 to identify patients who underwent stent insertion for malignant colorectal obstruction. Results Seventy-five patients (median age 75.2 years, 70.6% male) with primary colorectal cancer underwent stent insertion - 53 underwent semi-elective self-expanded metal stent insertion (for subacute bowel obstruction) and 22 had emergency stent inserted (for acute bowel obstruction)...
March 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28550027/exceptional-response-to-nivolumab-and-stereotactic-body-radiation-therapy-sbrt-in-neuroendocrine-cervical-carcinoma-with-high-tumor-mutational-burden-management-considerations-from-the-center-for-personalized-cancer-therapy-at-uc-san-diego-moores-cancer-center
#11
Andrew Sharabi, Sangwoo Shawn Kim, Shumei Kato, Philip D Sanders, Sandip Pravin Patel, Parag Sanghvi, Elizabeth Weihe, Razelle Kurzrock
Neuroendocrine carcinoma of the cervix is an ultra-rare malignancy with a poor prognosis and limited treatment options. Checkpoint blockade immunotherapy has rapidly developed into an emerging standard of care for several common disease types. Interestingly, in preclinical and retrospective clinical data, radiation therapy has been demonstrated to synergize with checkpoint inhibitors. Here we report a patient with metastatic, chemotherapy-refractory neuroendocrine carcinoma who presented with partial bowel obstruction due to a large tumor burden...
June 2017: Oncologist
https://www.readbyqxmd.com/read/28483604/selective-approach-for-patients-with-advanced-malignancy-and-gastrointestinal-obstruction
#12
Deep Pujara, Yi-Ju Chiang, Janice N Cormier, Eduardo Bruera, Brian Badgwell
BACKGROUND: The purpose of this study was to determine the frequency of tumor-related gastrointestinal obstruction and identify variables associated with functional outcomes and survival in patients with advanced malignancy and gastrointestinal obstruction. STUDY DESIGN: We reviewed the medical records of 490 patients with advanced cancer, who underwent surgical consultation for gastrointestinal obstruction between January 2000 and May 2014. We used chi-square and logistic regression analyses to identify variables associated with survival and eating at discharge...
July 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28458844/long-tract-ileocolic-intussusception-due-to-mucinous-adenocarcinoma-of-the-ileocecal-valve-a-case-report-and-literature-review
#13
E H Gruenberger, M Hassan, I Kratzke
Intussusception in adults lacks specific symptoms and is often diagnosed emergently when they present with obstruction. Though intussusception certainly varies in size and location, the increased likelihood of ischemia or obstruction make large intussusceptions very rare in the literature. A patient admitted to our facility for small bowel obstruction was found to have extensive intussusception from the right lower quadrant to the splenic flexure, where a lead point was identified. Histopathology revealed multiple satellite lesions surrounding the lead point tumor, which was found to be invasive mucinous adenocarcinoma of the ileocecal valve...
March 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28392363/stent-as-bridge-to-surgery-for-left-sided-malignant-colonic-obstruction-reduces-adverse-events-and-stoma-rate-compared%C3%A2-with-emergency-surgery-results-of-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
REVIEW
Alberto Arezzo, Roberto Passera, Giacomo Lo Secco, Mauro Verra, Marco Augusto Bonino, Eduardo Targarona, Mario Morino
BACKGROUND AND AIMS: Twenty years after the first description of the technique, the debate is still open on the role of self-expandable metallic stent (SEMS) placement as a bridge to elective surgery for symptomatic left-sided malignant colonic obstruction. The aim was to compare morbidity rates after colonic stenting bridge to surgery (SBTS) versus emergency surgery (ES) for left-sided malignant obstruction. METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) on SBTS or ES for acute symptomatic malignant left-sided large bowel obstruction...
September 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28386507/an-unusual-case-of-resistant-hypokalaemia-in-a-patient-with-large-bowel-obstruction-secondary-to-neuroendocrine-carcinoma-of-the-prostate
#15
Umasankar Mathuram Thiyagarajan, A Ponnuswamy, A Bagul, A Gupta
Neuroendocrine Carcinoma of the Prostate (NECP) is rare and only few cases have been reported, constituting less than 0.5% of prostatic malignancies. We report a rare case of large bowel obstruction from NECP posing a further challenge in management due to resistant hypokalaemia. A 70-year-old man presented with clinical signs of large bowel obstruction who was known to have prostatic carcinoma three years ago, treated initially with hormone therapy then chemoradiation. The blood profile showed a severe hypokalaemia and CT scan revealed liver and lung metastases apart from confirming large bowel obstruction from local invasion of NECP...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28289512/giant-abdominal-osteosarcoma-causing-intestinal-obstruction-treated-with-resection-and-adjuvant-chemotherapy
#16
Alexandros Diamantis, Grigorios Christodoulidis, Dionysia Vasdeki, Foteini Karasavvidou, Evangelos Margonis, Konstantinos Tepetes
Extraskeletal osteosarcoma (ESOS) is an uncommon tumor that accounts for 1% of all soft tissue sarcomas and 4% of all osteosarcomas. Its presentation may be atypical, while pain has been described as the most common symptom. Radiological findings include a large mass in the soft-tissues with massive calcifications, but no attachment to the adjacent bone or periosteum. We present the case of a 73-year-old gentle man who presented with a palpable, tender abdominal mass and symptoms of bowel obstruction. Computer tomography images revealed a large space-occupying heterogeneous, hyper dense soft tissue mass involving the small intestine...
February 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28265731/primary-surgery-for-malignant-large-bowel-obstruction-postoperative-nasogastric-tube-reinsertion-is-not-mandatory
#17
A Venara, J Barbieux, P A Colas, A Le Fouler, E Lermite, A Hamy
BACKGROUND: Malignant large bowel obstructions frequently require emergency surgery. Compliance with enhanced recovery after surgery programmes is significantly reduced due to non-removal of the nasogastric tube in the postoperative period. The first aim of the present study was to research factors associated with the failure of immediate nasogastric tube removal in patients who had undergone emergency surgery for malignant large bowel obstruction. The second aim was to assess the morbidity linked to nasogastric tube reinsertion...
July 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28156641/in-search-of-the-optimal-outcome-measure-for-patients-with-advanced-cancer-and-gastrointestinal-obstruction-a-qualitative-research-study
#18
Loretta A Williams, Eduardo Bruera
100 Background: Gastrointestinal obstruction (GIO) is the most common indication for palliative surgical consultation in patients with advanced cancer. The purpose of this study was to delineate the symptom burden and experience of patients with GIO. METHODS: Twenty patients with advanced cancer and GIO described symptoms at the time of surgical consultation. We used content analysis of interview transcripts and symptoms were ranked by frequency and compared to a general symptom assessment survey (MD Anderson Symptom Inventory)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28097296/long-term-postprocedural-outcomes-of-palliative-emergency-stenting-vs-stoma-in-malignant-large-bowel-obstruction
#19
COMPARATIVE STUDY
Jonathan S Abelson, Heather L Yeo, Jialin Mao, Jeffrey W Milsom, Art Sedrakyan
Importance: Colonic stenting was introduced for palliation of malignant large-bowel obstruction (MLBO) more than 20 years ago but remains controversial. Objective: To compare outcomes after palliative stenting vs stoma creation in patients with MLBO requiring emergency management. Design, Setting, and Participants: This observational cohort study assessed 345 patients from New York State with an urgent or emergency admission to the hospital for obstruction secondary to colorectal cancer and who underwent stenting or stoma creation from October 1, 2009, through December 31, 2013...
May 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28050471/spectrum-of-mdct-findings-in-bowel-obstruction-in-a-tertiary-care-rural-hospital-in-northern-india
#20
Ranjana Gupta, Puneet Mittal, Amit Mittal, Sharad Gupta, Kapish Mittal, Arpit Taneja
INTRODUCTION: Multidetector Computed Tomography (MDCT) provides clinically and surgically important information in bowel obstruction. It can depict the severity, level and cause of obstruction. AIM: To depict the spectrum of MDCT findings in cases of small and large bowel obstruction. MATERIALS AND METHODS: Contrast enhanced MDCT examination of 50 patients were retrospectively included in the study who had evidence of clinical as well as MDCT evidence of bowel obstruction and in whom surgical/clinical follow-up for final diagnosis was available...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
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