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https://www.readbyqxmd.com/read/29928706/variability-of-clinical-target-volume-delineation-for-rectal-cancer-patients-planned-for-neoadjuvant-radiotherapy-with-the-aid-of-the-platform-anatom-e
#1
Pierfrancesco Franco, Francesca Arcadipane, Elisabetta Trino, Elena Gallio, Stefania Martini, Giuseppe Carlo Iorio, Cristina Piva, Francesco Moretto, Maria Grazia Ruo Redda, Roberta Verna, Vassiliki Tseroni, Cristina Bona, Gabriele Pozzi, Christian Fiandra, Riccardo Ragona, Oscar Bertetto, Umberto Ricardi
Objective: Delineation of treatment volumes is a major source of uncertainties in radiotherapy (RT). This is also true for rectal cancer patients undergoing neoadjuvant RT, with a potential impact on treatment quality. We investigated the role of the digital platform Anatom-e (Anatom-e Information Sytems Ltd., Houston, Texas) in increasing the compliance to follow a specific treatment protocol in a multicentric setting. Materials and methods: Two clinical cases of locally advanced rectal cancer were chosen...
June 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29928215/an-unusual-coexistence-of-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-with-endometrioid-type-endometrial-cancer-in-a-58-year-old-woman-a-case-study-with-literature-review
#2
Dominik Dłuski, Dorota Lewkowicz, Bożena Leszczyńska-Gorzelak, Bogdan Obrzut, Tomasz Rechberger, Andrzej Semczuk
Introduction: The coexistence of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with different gynecologic neoplasms is a rare phenomenon. Here, we report a case of simultaneously developed CLL/SLL with endometrioid-type uterine cancer. Case Report: A 58-year-old woman was admitted to the 2nd Department of Gynecology, Lublin Medical University, Lublin, Poland, in June 2017, where the uterine cancer was diagnosed. After the surgery, pathological examination revealed a uterine moderately differentiated adenocarcinoma of endometrioid subtype (subtype I according to Bokhman) deeply infiltrating the myometrium as well as the uterine cervix...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29926338/outcomes-of-transoral-laser-microsurgery-for-oropharyngeal-squamous-cell-carcinoma-in-ireland-and-review-of-the-literature-on-transoral-approaches
#3
Robbie S R Woods, Lina Geyer, Ana Ionescu, Deirdre Callanan, Patrick Sheahan
BACKGROUND: The optimal treatment for oropharyngeal squamous cell carcinoma (OPSCC) is controversial. There is increasing evidence that, in selected cases, minimally invasive transoral surgery can offer improved functional outcomes, with equivalent oncologic outcomes, compared to chemoradiotherapy. AIMS: We report the outcomes of transoral laser microsurgery (TLM) for treatment of OPSCC at our institution. METHODS: Patients with OPSCC undergoing TLM at the South Infirmary Victoria University Hospital, Cork, between 2010 and 2016, were identified from an institutional database...
June 21, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29925410/adjuvant-radiation-therapy-for-malignant-abrikossoff-s-tumor-a-case-report-about-a-femoral-triangle-localisation
#4
C Marchand Crety, C Garbar, G Madelis, F Guillemin, P Soibinet Oudot, J C Eymard, S Servagi Vernat
BACKGROUND: Granular cell or Abrikossoff's tumors are usually benign however rare malignant forms concern 1 to 3% of cases reported. Pelvic locations are exceptional. CASE PRESENTATION: We report a case of a 43-years-old patient who had a benign Abrikossoff's tumor localized in the right femoral triangle diagnosed at the biopsy. The patient underwent a surgical tumorectomy and inguinal lymph nodes resection. Histologically, the tumor showed enough criteria to give diagnosis of malignancy: nuclear pleomorphism, tumor cell spindling, vesicular nuclei with large nucleoli...
June 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29924914/the-efficacy-of-ultrasound-in-the-follow-up-after-a-negative-sentinel-lymph-node-in-vulvar-cancer-patients-a-prospective-single-center-study
#5
Anne-Floor W Pouwer, Roel D M Mus, Joanna IntHout, Ate G J van der Zee, Johan Bulten, Leon F A G Massuger, Joanne A de Hullu
OBJECTIVE: To determine the efficacy of the addition of an ultrasound of the groins in routine follow-up of patients with vulvar squamous cell carcinoma (SCC) after a negative sentinel lymph node (SLN). DESIGN: Prospective single center study. SETTING: A tertiary expert oncology center for the treatment of vulvar cancer. POPULATION: All vulvar SCC patients with a negative SLN, treated between 2006 and 2014. METHODS: We prospectively collected data of 139 vulvar SCC patients treated with a SLN procedure...
June 20, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29924704/effects-of-surgery-with-salvage-stereotactic-radiosurgery-versus-surgery-with-whole-brain-radiation-therapy-in-patients-with-one-to-four-brain-metastases-jcog0504-a-phase-iii-noninferiority-randomized-controlled-trial
#6
Takamasa Kayama, Shinya Sato, Kaori Sakurada, Junki Mizusawa, Ryo Nishikawa, Yoshitaka Narita, Minako Sumi, Yasuji Miyakita, Toshihiro Kumabe, Yukihiko Sonoda, Yoshiki Arakawa, Susumu Miyamoto, Takaaki Beppu, Kazuhiko Sugiyama, Hirohiko Nakamura, Motoo Nagane, Yoko Nakasu, Naoya Hashimoto, Mizuhiko Terasaki, Akira Matsumura, Eiichi Ishikawa, Toshihiko Wakabayashi, Yasuo Iwadate, Shiro Ohue, Hiroyuki Kobayashi, Manabu Kinoshita, Kenichiro Asano, Akitake Mukasa, Katsuyuki Tanaka, Akio Asai, Hideo Nakamura, Tatsuya Abe, Yoshihiro Muragaki, Koichi Iwasaki, Tomokazu Aoki, Takao Watanabe, Hikaru Sasaki, Shuichi Izumoto, Masahiro Mizoguchi, Takayuki Matsuo, Hideo Takeshima, Motohiro Hayashi, Hidefumi Jokura, Takashi Mizowaki, Eiji Shimizu, Hiroki Shirato, Masao Tago, Hiroshi Katayama, Haruhiko Fukuda, Soichiro Shibui
Purpose Whereas whole-brain radiotherapy (WBRT) has been the standard treatment of brain metastases (BMs), stereotactic radiosurgery (SRS) is increasingly preferred to avoid cognitive dysfunction; however, it has not been clearly determined whether treatment with SRS is as effective as that with WBRT or WBRT plus SRS. We thus assessed the noninferiority of salvage SRS to WBRT in patients with BMs. Patients and Methods Patients age 20 to 79 years old with performance status scores of 0 to 2-and 3 if caused only by neurologic deficits-and with four or fewer surgically resected BMs with only one lesion > 3 cm in diameter were eligible...
June 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29924229/prevalence-of-dermatological-complaints-in-patients-undergoing-treatment-for-breast-cancer
#7
Tamara Hoffmann, Mariane Corrêa-Fissmer, Camila Soares Duarte, Rayane Felippe Nazário, Ana Beatriz Sanches Barranco, Karen Waleska Knipoff de Oliveira
BACKGROUND: Internal malignancies such as breast cancer, as well as their treatment can often result in skin changes. OBJECTIVE: To assess the prevalence of dermatological complaints in patients who are undergoing oncological treatment for breast cancer in a hospital in Tubarão, Santa Catarina, Brazil. METHODS: Observational, cross-sectional study, from October 2015 to February 2016 in which 152 patients with the diagnosis of breast cancer, undergoing treatment with chemotherapy, radiotherapy, hormone therapy and/or surgery, were interviewed and completed a research protocol developed by the author...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29921544/management-of-localised-prostate-cancer-in-kidney-transplant-patients-a-systematic-review-from-the-eau-guidelines-on-renal-transplantation-panel
#8
REVIEW
Vital Hevia, Romain Boissier, Óscar Rodríguez-Faba, Claire Fraser-Taylor, Rhana Hassan-Zakri, Enrique Lledo, Heinz Regele, Klemens Buddde, Arnaldo Figueiredo, Jonathon Olsburgh, Alberto Breda
CONTEXT: Cancer development after kidney transplant (KT) has become a major problem, and currently, it is one of the primary causes of death in this population. Urological cancers after KT such as prostate cancer (PCa) have also increased, partly due to the increasing age of recipients and prolonged survival. PCa is the second most commonly diagnosed cancer in men, accounting for 15% of all cancers. Managing localised PCa after KT remains challenging because of treating an immunosuppressed patient with a kidney graft in the pelvic cavity...
June 16, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29920481/locally-advanced-cervical-cancer-is-a-trimodality-treatment-a-safe-and-effective-approach
#9
Domenica Lorusso, Fabio Martinelli, Giuseppa Maltese, Caterina Fontanella, Ilaria Sabatucci, Antonino Ditto, Mauro Signorelli, Giorgio Bogani, Stefano Lepori, Elisa Tripodi, Brigida Pappalardi, Cono Scaffa, Annamaria Cerrotta, Francesco Rapagliesi
BACKGROUND: Chemoradiotherapy (CRT) is the standard of care for locally advanced cervical cancer (LACC). Pre-treatment lymph nodes (LN) assessment may have an important therapeutic role. CRT followed by adjuvant chemotherapy increased progression free survival (PFS) and overall survival (OS). Our study evaluated the feasibility and the effectiveness of a trimodality strategy in patients with LACC and positive LN. METHODS: Consecutive patients with LACC treated at the National Cancer Institute of Milan were enrolled...
June 19, 2018: Oncology
https://www.readbyqxmd.com/read/29914619/the-treatment-of-gliomas-in-adulthood
#10
Roland Goldbrunner, Maximilian Ruge, Martin Kocher, Carolin Weiss Lucas, Norbert Galldiks, Stefan Grau
BACKGROUND: Gliomas are the most common intrinsic tumors of the brain, with an incidence of 6 per 100 000 persons per year. Recent years have seen marked changes in the diagnosis and treatment of gliomas, with molecular parameters now being an integral part of the diagnostic evaluation. METHODS: This review is based on pertinent articles retrieved by a selective search in PubMed, with special attention to the new WHO glioma classification. RESULTS: The classification of gliomas on the basis of additional molecular parameters enables more accurate prognostication and serves as a basis for therapeutic decision-making and treatment according to precisely specified algorithms...
May 21, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29913254/patient-reported-outcomes-in-nrg-oncology-rtog-0938-evaluating-two-ultrahypofractionated-regimens-for-prostate-cancer
#11
Himanshu R Lukka, Stephanie L Pugh, Deborah W Bruner, Jean-Paul Bahary, Colleen A F Lawton, Jason A Efstathiou, Rajat J Kudchadker, Lee E Ponsky, Samantha A Seaward, Ian S Dayes, Darindra D Gopaul, Jeff M Michalski, Guila Delouya, Irving D Kaplan, Eric M Horwitz, Mack Roach, Wayne H Pinover, David C Beyer, John O Amanie, Howard M Sandler, Lisa A Kachnic
BACKGROUND: There is considerable interest in very short (ultrahypofractionated) radiotherapy regimens to treat prostate cancer based on potential radiobiological advantages, patient convenience and resource allocation benefits. OBJECTIVE: To demonstrate that detectable changes in health related quality of life measured by the bowel and urinary domains of the Expanded Prostate Cancer Index Composite (EPIC-50) were not substantially worse than baseline. DESIGN, SETTING, AND PARTICIPANTS: XXXX is a non-blinded randomized phase II study of NCCN low risk prostate cancer where each arm is compared to a historical control...
June 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29910831/postoperative-radiotherapy-after-nipple-or-skin-sparing-mastectomy-a-review-of-recent-institutional-and-pooled-data
#12
REVIEW
Jacques Bernier
The increasing use of nipple-sparing mastectomy (NSM) and skin-sparing mastectomy (SSM) in the treatment of nonmetastatic breast cancer is justified by considerations linked to their therapeutic index. In selected patients, efficacy results tend to be similar to those observed after radical modified mastectomy and at the same time, subcutaneous mastectomies preserve the patient's body image. Yet the oncologic safety of the two former surgical approaches is still a matter of debate, also in consideration of the almost complete absence of clinical studies directed to prospective, controlled comparisons between subcutaneous and radical modified mastectomies...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29909895/magnitude-of-benefit-for-adjuvant-radiotherapy-following-minimally-invasive-surgery-in-intermediate-to-high-risk-hpv-positive-oropharyngeal-squamous-cell-carcinoma
#13
Dario Pasalic, Ryan K Funk, Joaquín J García, Daniel L Price, Katharine A Price, William S Harmsen, Samir H Patel, Geoffrey D Young, Robert L Foote, Eric J Moore, Daniel J Ma
OBJECTIVE: To determine the outcomes and toxicities of minimally-invasive surgery with adjuvant intensity-modulated radiotherapy +/- chemotherapy (AT) compared to definitive surgical therapy (ST) in a contemporary cohort of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). METHODS: From 2005 to 2013, a consecutive cohort of 190 HPV-positive OPSCC patients was retrospectively reviewed from multi-institutional databases maintained by the Departments of Otorhinolaryngology and Radiation Oncology...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909893/impact-of-radical-treatments-on-survival-in-locally-advanced-t4a-and-t4b-buccal-mucosa-cancers-selected-surgically-treated-t4b-cancers-have-similar-control-rates-as-t4a
#14
Manish D Mair, Noopur Sawarkar, Santosh Nikam, Rajiv Sarin, Deepa Nair, Tejpal Gupta, Pankaj Chaturvedi, Anil D'cruz, Sudhir Nair
INTRODUCTION: In the absence of any robust data supporting the TNM classification of T4 buccal mucosa cancers, we did this prospective study to compare the oncologic outcomes of T4a and T4b buccal mucosa cancer patients. PATIENTS AND METHODS: This is a prospective study of 210 treatment naïve T4 buccal mucosa cancer patients. All patients underwent upfront radical surgery followed by adjuvant radiotherapy (RT)/chemoradiotherapy (CCRT). This is the largest prospective series in the literature on T4 buccal cancers...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909887/smoking-impact-on-hpv-driven-head-and-neck-cancer-s-oncological-outcomes
#15
Haitham Mirghani, Charlotte Leroy, Younes Chekourry, Odile Casiraghi, Anne Aupérin, Yungan Tao, France Nguyen, Even Caroline, Ingrid Breuskin, Antoine Moya Plana, Dana Hartl, François Janot, Stéphane Temam, Philippe Gorphe, Pierre Blanchard
INTRODUCTION: HPV-driven oropharyngeal cancer (OPC) patients have a better prognosis than their HPV-negative counterparts but several studies have suggested that among HPV-positive patients those with a smoking history had worse oncological outcomes. The aim of our study is to characterize the interplay between tobacco consumption, patient and disease characteristics, and disease control. MATERIALS AND METHODS: All patients diagnosed with HPV-driven OPC and treated with curative intent between 2007 and 2009 and 2011-2016 at Gustave Roussy cancer center were included (n = 282)...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29908990/development-and-validation-of-response-markers-to-predict-survival-and-pleurodesis-success-in-patients-with-malignant-pleural-effusion-promise-a-multicohort-analysis
#16
Ioannis Psallidas, Nikolaos I Kanellakis, Stephen Gerry, Marie Laëtitia Thézénas, Philip D Charles, Anastasia Samsonova, Herbert B Schiller, Roman Fischer, Rachelle Asciak, Robert J Hallifax, Rachel Mercer, Melissa Dobson, Tao Dong, Ian D Pavord, Gary S Collins, Benedikt M Kessler, Harvey I Pass, Nick Maskell, Georgios T Stathopoulos, Najib M Rahman
BACKGROUND: The prevalence of malignant pleural effusion is increasing worldwide, but prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified. The PROMISE study was designed with the objectives to discover, validate, and prospectively assess biomarkers of survival and pleurodesis response in malignant pleural effusion and build a score that predicts survival. METHODS: In this multicohort study, we used five separate and independent datasets from randomised controlled trials to investigate potential biomarkers of survival and pleurodesis...
June 13, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29908524/neoadjuvant-radiotherapy-changing-the-treatment-sequence-to-allow-immediate-free-autologous-breast-reconstruction
#17
Kimberley Hughes, Derek Neoh
BACKGROUND:  Locally advanced breast cancer (LABC) is traditionally treated with a multimodal approach of chemotherapy, surgery, and postmastectomy radiotherapy (PMRT). The advantages of immediate breast reconstruction (IBR) are well described and include improved aesthetic outcomes, fewer surgical procedures, shorter treatment period, and a higher quality of life. However, this sequence makes immediate free autologous reconstruction more challenging as PMRT can have deleterious and unpredictable effects on the flap...
June 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29907490/multi-institutional-study-of-carbon-ion-radiotherapy-for-locally-advanced-pancreatic-cancer-japan-carbon-ion-radiation-oncology-study-group-j-cros-study-1403-pancreas
#18
Shohei Kawashiro, Shigeru Yamada, Masahiko Okamoto, Tatsuya Ohno, Takashi Nakano, Makoto Shinoto, Yoshiyuki Shioyama, Kenji Nemoto, Yuka Isozaki, Hiroshi Tsuji, Tadashi Kamada
PURPOSE: The aim of this multi-institutional study was to evaluate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for locally advanced pancreatic cancer (LAPC). METHODS AND MATERIALS: Patients with LAPC treated with C-ion RT from April 2012 to December 2014 at 3 institutions were retrospectively analyzed. Patients with pathologically-confirmed invasive ductal adenocarcinoma of the pancreas were eligible. The prescribed dose was 52.8 Gy (relative biological effectiveness weighted absorbed dose; RBE) or 55...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29907475/radiotherapy-for-langerhans-cell-histiocytosis-with-paraplegia-a-rare-oncologic-emergency-case-report-in-infancy-and-literature-review
#19
Kentaro Nakashima, Yuhki Koga, Yasunari Sakai, Hidetoshi Takada, Katsumi Harimaya, Saiji Ohga, Tomoaki Taguchi, Yoshinao Oda, Hiroshi Honda, Shouichi Ohga
BACKGROUND: Langerhans cell histiocytosis (LCH) is a clonal disease with focal or disseminated lesions that may compress the surrounding tissues, including the spinal cord. Because few reports have described the spinal symptoms as the first manifestation of pediatric LCH, the long-term neurological outcomes remain unclear. CASE REPORT AND LITERATURE REVIEW: We report a 21-month-old boy who presented with sudden-onset paraplegia. Imaging analyses revealed that osteolytic lesions and epidural tumors compressing the spinal cord at the T7-9 vertebrae...
June 12, 2018: Brain & Development
https://www.readbyqxmd.com/read/29905401/monitoring-pulmonary-health-in-swiss-childhood-cancer-survivors
#20
Rahel Kasteler, Linda M H Kam, Annette Weiss, Nicolas Waespe, Grit Sommer, Florian Singer, Nicolas X von der Weid, Marc Ansari, Claudia E Kuehni
BACKGROUND: Childhood cancer survivors are at increased risk for pulmonary morbidity and mortality. International guidelines recommend pulmonary function tests (PFT) during follow-up care. This nationwide study assessed how many children received PFT within 5 years after pulmotoxic treatment in Switzerland, types of tests, and predictors for testing. METHODS: We included all children from the Swiss Childhood Cancer Registry who were diagnosed with cancer from 1990 to 2013 at age 0-16 years, survived for ≥2 years from diagnosis, and had pulmotoxic chemotherapy with bleomycin, busulfan, nitrosoureas, and/or chest radiotherapy...
June 15, 2018: Pediatric Blood & Cancer
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