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optical coherence tomography angiography

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https://www.readbyqxmd.com/read/28328965/peripheral-blood-metabolic-and-inflammatory-factors-as-biomarkers-to-ocular-findings-in-diabetic-macular-edema
#1
Marc Figueras-Roca, Blanca Molins, Anna Sala-Puigdollers, Jessica Matas, Irene Vinagre, José Ríos, Alfredo Adán
AIMS: To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients. MATERIAL AND METHODS: Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients...
2017: PloS One
https://www.readbyqxmd.com/read/28322323/anti-inflammatory-properties-of-shikonin-contribute-to-improved-early-stage-diabetic-retinopathy
#2
Po-Lin Liao, Cheng-Hui Lin, Ching-Hao Li, Chi-Hao Tsai, Jau-Der Ho, George C Y Chiou, Jaw-Jou Kang, Yu-Wen Cheng
Diabetic retinopathy (DR), a major microvascular complication of diabetes, leads to retinal vascular leakage, neuronal dysfunction, and apoptosis within the retina. In this study, we combined STZ with whole-body hypoxia (10% O2) for quicker induction of early-stage retinopathy in C57BL/6 mice. We also compared the effects of a high glucose condition combined with hypoxia (1% O2) to a low glucose condition by using retinal pigment epithelial (RPE) cells, which are a crucial component of the outer blood-retinal barrier and the damage is related to retinopathy...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28320481/cystoid-macular-edema-associated-with-preservative-free-latanoprost-after-uncomplicated-cataract-surgery-case-report-and-review-of-the-literature
#3
Olga E Makri, Foteini N Tsapardoni, Panagiotis Plotas, Nikistratos Ifantis, Paraskevi T Xanthopoulou, Constantine D Georgakopoulos
BACKGROUND: Cystoid macular edema associated with latanoprost administration has been reported in patients after complicated cataract surgery with coexisting risk factors. We present the first case of preservative free latanoprost associated cystoid macular edema that occurred many months after uncomplicated cataract surgery. CASE PRESENTATION: A 65-year old Caucasian female presented in the Outpatients Clinic complaining of reduced vision and metamorphopsia in the right eye...
March 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28318637/impact-of-multiple-en-face-image-averaging-on-quantitative-assessment-from-optical-coherence-tomography-angiography-images
#4
Akihito Uji, Siva Balasubramanian, Jianqin Lei, Elmira Baghdasaryan, Mayss Al-Sheikh, SriniVas R Sadda
PURPOSE: To investigate the impact of multiple en face image averaging on quantitative measurements of the retinal microvasculature using optical coherence tomography angiography (OCTA). DESIGN: Prospective, observational, cross-sectional case series. PARTICIPANTS: Twenty-one healthy individuals with normal eyes. METHODS: Macular OCTA images were acquired from all participants using the Zeiss Cirrus 5000 with Angioplex OCTA software (Carl Zeiss Meditec, Dublin, CA)...
March 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28316838/retinal-vessel-density-in-optical-coherence-tomography-angiography-in-optic-atrophy-after-nonarteritic-anterior-ischemic-optic-neuropathy
#5
Chun-Hsiu Liu, Ling-Yuh Kao, Ming-Hui Sun, Wei-Chi Wu, Henry Shen-Lih Chen
Aims. To compare optical coherence tomography angiography (OCT-A) retinal vasculature measurements between normal and optic atrophy after nonarteritic anterior ischemic optic neuropathy (NAION) subjects. Design. This prospective observational study was conducted between July 2015 and August 2016 at the ophthalmology outpatient department of a referral center in Taiwan. Peripapillary (4.5 × 4.5 mm) and parafoveal (6 × 6 mm) OCT-A scans were acquired. Measurements of the peripapillary region were obtained in two areas: (1) circumpapillary vessel density (cpVD) and (2) whole enface image vessel density (wiVD)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28314954/retinal-and-choroidal-vascular-features-in-patients-with-retinitis-pigmentosa-imaged-by-oct-based-microangiography
#6
Kasra A Rezaei, Qinqin Zhang, Chieh-Li Chen, Jennifer Chao, Ruikang K Wang
PURPOSE: To image vascular features of retinitis pigmentosa (RP) using optical coherence tomography angiography (OCTA). METHODS: Patients with RP were imaged by spectral domain optical coherence tomography based angiography (OCTA). The optical microangiography (OMAG) algorithm was applied to scanned datasets to generate 3D OCTA retinal angiograms, i.e., OMAG angiograms. Motion tracking was used to minimize artifacts due to eye movement, and large field of view OMAG angiograms were achieved through a montage scanning protocol...
March 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28314832/features-of-the-choriocapillaris-in-myopic-maculopathy-identified-by-optical-coherence-tomography-angiography
#7
Kaori Sayanagi, Yasushi Ikuno, Sato Uematsu, Kohji Nishida
AIM: To describe the choriocapillaris features imaged by optical coherence tomography angiography (OCTA) in eyes with myopic maculopathy. METHODS: In this retrospective, non-invasive, observational case series, 26 eyes with myopic maculopathy and 12 age-matched healthy eyes underwent fluorescein angiography, indocyanine green angiography (ICGA) (highly myopic eyes only), OCT and OCTA, and the choriocapillaris features seen on OCTA and ICGA were compared. RESULTS: In all five (19%) eyes with patchy atrophy of the 26 highly myopic eyes, OCTA showed complete loss of the choriocapillaris and large choroidal vessels in the atrophic area...
March 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28303068/high-dose-intravenous-pulse-steroid-therapy-for-optic-disc-swelling-and-subretinal-fluid-in-non-arteritic-anterior-ischemic-optic-neuropathy
#8
Kei Takayama, Hiroki Kaneko, Shu Kachi, Eimei Ra, Yasuki Ito, Hiroko Terasaki
Non-arteritic anterior ischemic optic neuropathy (NAION) is a disease with microvascular abnormality that causes acute optic disc swelling (ODS) and, in severe cases, subretinal fluid (SRF) accumulation. ODS causes compartment syndrome and subsequent axonal degeneration and loss of retinal ganglion cells by apoptosis. No treatment modalities have been effective, although some cases improved after the intake of oral systemic steroids. We reported a case of a 72-year-old man who was referred due to a visual defect in the right eye...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28301863/optical-coherence-tomography-angiography-in-nonarteritic-anterior-ischemic-optic-neuropathy
#9
Emily Wright Mayes, Emily D Cole, Sabin Dang, Eduardo A Novais, Laurel Vuong, Carlos Mendoza-Santiesteban, Jay S Duker, Thomas R Hedges
BACKGROUND: Optical coherence tomography angiography (OCTA) has demonstrated good utility in qualitative analysis of retinal and choroidal vasculature and therefore may be relevant in the diagnostic and treatment efforts surrounding nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: Retrospective, cross-sectional study of 10 eyes of 9 patients with a previous or new diagnosis of NAION that received imaging with OCTA between November 2015 and February 2016...
March 15, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28301857/structural-and-functional-characterization-of-benign-fleck-retina-using-multimodal-imaging
#10
Srividya Neriyanuri, Chetan Rao, Rajiv Raman
PURPOSE: To report structural and functional features in a case series of benign fleck retina using multimodal imaging. METHODS: Four cases with benign fleck retina underwent complete ophthalmic examination that included detailed history, visual acuity, and refractive error testing, FM-100 hue test, dilated fundus evaluation, full field electroretinogram, fundus photography with autofluorescence, fundus fluorescein angiography, and swept-source optical coherence tomography...
April 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28299497/multimodal-imaging-in-a-case-of-butterfly-pattern-dystrophy-of-retinal-pigment-epithelium
#11
Vinod Kumar, Devesh Kumawat
AIMS: To report multi-modal imaging findings in a case of butterfly pattern dystrophy of retinal pigment epithelium. METHODS: A middle-aged female with butterfly pattern dystrophy, who presented with progressive loss of vision, was examined using coloured fundus photographs, short wave autofluorescence, swept source optical coherence tomography (SS-OCT), fundus fluorescein angiography and enface optical coherence tomography. RESULTS: Multi-modal imaging was useful in the characterization of the various disease features...
March 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28299012/optical-coherence-tomography-angiography-of-the-optic-disc-an-overview
#12
REVIEW
Handan Akil, Khalil Ghasemi Falavarjani, Srinivas R Sadda, Alfredo A Sadun
Different diseases of the optic disc may be caused by or lead to abnormal vasculature at the optic nerve head. Optical coherence tomography angiography (OCTA) is a novel technology that provides high resolution mapping of the retinal and optic disc vessels. Recent studies have shown the ability of OCTA to visualize vascular abnormalities in different optic neuropathies. In addition, quantified OCTA measurements were found promising for differentiating optic neuropathies from healthy eyes.
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28299008/intravitreal-injection-of-bone-marrow-mesenchymal-stem-cells-in-patients-with-advanced-retinitis-pigmentosa-a-safety-study
#13
Leila Satarian, Ramin Nourinia, Sare Safi, Mozhgan Rezaei Kanavi, Neda Jarughi, Narsis Daftarian, Leila Arab, Nasser Aghdami, Hamid Ahmadieh, Hossein Baharvand
PURPOSE: To examine the safety of a single intravitreal injection of autologous bone Marrow Mesenchymal stem cells (MSCs) in patients with advanced retinitis pigmentosa (RP). METHODS: A prospective, phase I, nonrandomized, open-label study was conducted on 3 eyes of 3 volunteers with advanced RP. Visual acuity, slit-lamp examination, fundus examination, optical coherence tomography, fundus auto-fluorescence, fluorescein angiography and multifocal electroretinography were performed before and after an intravitreal injection of approximately one-million MSCs...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28299006/characteristics-of-macular-edema-in-behcet-disease-after-intravitreal-bevacizumab-injection
#14
Fariba Ghassemi, Sohrab Afshari Mirak, Hormoz Chams, Siamak Sabour, Mehdi Nilli Ahmadabadi, Fereidoun Davatchi, Farhad Shahram
PURPOSE: To investigate the effect of intravitreal bevacizumab (IVB) injection on macular edema (ME) secondary to Behcet's disease. METHODS: This prospective case series included 15 patients with bilateral ME due to Behcet's disease. Intravitreal bevacizumab was injected into the more severely involved eye; the contralateral eye was evaluated as the control. Patients were followed up with comprehensive ocular examination, optical coherence tomography, and fluorescein angiography (FA) for a minimum of 6 months by a single ophthalmologist...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28297041/fluorescein-angiography-versus-optical-coherence-tomography-angiography-in-macular-telangiectasia-type-i-treated-with-bevacizumab-therapy
#15
Nicolas A Yannuzzi, Ninel Z Gregori, Luiz Roisman, Nisha Gupta, Brian E Goldhagen, Raquel Goldhardt
This is a report of microvascular changes seen on fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) in a 47-year-old man with macular telangiectasia Type 1 (MacTel1) after a 7-year bevacizumab (Avastin; Genentech, South San Francisco, CA) treatment course. OCTA allowed for clear visualization of most telangiectasias and aneurysms in the deep capillary plexus, with only few microvascular dilatations in the superficial plexus. In addition, areas of capillary dropout in the superficial and deep vascular plexa located near telangiectasias were documented on OCTA...
March 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28297029/alterations-of-the-foveal-avascular-zone-measured-by-optical-coherence-tomography-angiography-in-glaucoma-patients-with-central-visual-field-defects
#16
Junki Kwon, Jaewan Choi, Joong Won Shin, Jiyun Lee, Michael S Kook
Purpose: To investigate whether the area and shape of the foveal avascular zone (FAZ) as assessed by optical coherence tomography angiography (OCTA) are altered in glaucomatous eyes with central visual field defects (CVFDs). Methods: A total of 78 patients with open-angle glaucoma with central or peripheral visual field defects (PVFDs) confined to a single hemifield were studied retrospectively. Foveal avascular zone area and circularity were measured using OCTA images from the superficial retinal layer...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28297027/underlying-microstructure-of-parapapillary-deep-layer-capillary-dropout-identified-by-optical-coherence-tomography-angiography
#17
Eun Ji Lee, Tae-Woo Kim, Seung Hyen Lee, Jung-Ah Kim
Purpose: To characterize the microstructure underlying the parapapillary deep-layer microvasculature dropout (MvD) identified by optical coherence tomography (OCT) angiography (OCTA) in eyes with primary open-angle glaucoma (POAG). Methods: Parapapillary MvD was defined as a focal sectoral capillary dropout without any visible microvascular network identified in deep-layer en face images obtained using swept-source OCTA. The peripapillary microstructure was characterized in 188 POAG patients with MvD in the parapapillary deep layer...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28293432/diabetic-retinopathy-and-oct-angiography-clinical-findings-and-future-perspectives
#18
REVIEW
Jose Mauricio Botto de Barros Garcia, David Leonardo Cruvinel Isaac, Marcos Avila
In diabetic retinopathy (DR), macular involvement can present as either macular edema or ischemia. Fluorescein angiography remains the gold standard in the evaluation of retinal vascular perfusion and diagnosis of macular ischemia. However, it is a costly, time-consuming technique, it requires venipuncture, and reports of anaphylaxis and death related to fluorescein injections have been documented, despite their rarity. Optical coherence tomography (OCT) provides a fast and non-invasive method to assess retinal structures at a microscopic level...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28289840/angioscopic-and-optical-coherence-tomographic-evaluation-of-neointimal-coverage-9%C3%A2-months-after-expandable-polyterafluoroethylene-covered-stent-implantation
#19
Ken Kongoji, Yuki Ishibashi, Nozomi Kotoku, Mizuho Kasahara, Hiroshi Yamazaki, Takanobu Mitarai, Ryo Kamijima, Kohei Koyama, Kihei Yoneyama, Yasuhiro Tanabe, Yoshihiro J Akashi
An expandable polytetrafluoroethylene (ePTFE) covered stent is generally employed to seal coronary artery perforation. The frequency of ePTFE covered stent use is relatively low; thus, only a handful of studies have reported neointimal coverage and endothelialization inside the deployed ePTFE and clinical time course after ePTFE implantation. This case report presents a 78-year-old man treated with an ePTFE covered stent when he suffered from coronary artery perforation after the implantation of two everolimus eluting stents in the left anterior descending artery...
March 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28288185/a-comparison-of-the-diagnostic-ability-of-vessel-density-and-structural-measurements-of-optical-coherence-tomography-in-primary-open-angle-glaucoma
#20
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Mohammed Riyazuddin, Srilakshmi Dasari, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To compare the diagnostic abilities of vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary open angle glaucoma (POAG) with that of the ONH rim area, peripapillary retinal nerve fiber layer (RNFL) thickness and the macular ganglion cell complex (GCC) thickness measurements. METHODS: In a cross sectional study, 78 eyes of 50 control subjects and 117 eyes of 67 POAG patients underwent vessel density and structural measurements with spectral domain OCT...
2017: PloS One
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