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optical coherence tomography angiography

Chui Ming Gemmy Cheung, Yasuo Yanagi, Masahiro Akiba, Anna Tan, Ranjana Mathur, Choi Mun Chan, Ian Yeo, Tien Y Wong
PURPOSE: To assess the ability of optical coherence tomography (OCT) alone and in combination with OCT angiography (OCTA) to differentiate polypoidal choroidal vasculopathy (PCV) from neovascular age-related macular degeneration, as compared to fluorescein angiography and indocyanine green angiography. METHODS: This is a cross-sectional study. All participants had a standardized history, clinical examination including measurement of best-corrected visual acuity, slit-lamp biomicroscopy, and indirect fundus examination, and underwent standardized imaging (color photography, fluorescein and indocyanine green angiography, OCT, and OCTA) after predefined protocols...
June 20, 2018: Retina
Umesh Chandra Behera, Arshi Singh, Lubhani Jain, Alisha Desai
The early clinical manifestations of macular infarction secondary to subconjunctival gentamicin (Gentak; Akorn, Lake Forest, IL) use in an aphakic eye were documented sequentially on swept-source optical coherence tomography (OCT) and fundus fluorescein angiography. The first recorded event after drug toxicity was macular detachment, along with disorganization of outer retinal layers in about 12 hours. The changes in inner retinal layers occurred after 36 hours had elapsed. OCT-documented initial damage to outer retinal layers could be due to the susceptibility of first order retinal neurons, followed by subsequent inner retinal layer involvement and ischemia...
June 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Dilraj S Grewal, Bryce W Polascik, Gregory C Hoffmeyer, Sharon Fekrat
The authors report the optical coherence tomography angiography (OCTA)-based comparative assessment of the retinal microvasculature in a rare pair of 96-year-old female monozygotic twins discordant for Alzheimer's disease (AD). Using automated mapping of the superficial capillary plexus, the authors observed that the twin with advanced AD had a significantly reduced vessel density and a larger foveal avascular zone in the superficial capillary plexus as well as a thinner choroid compared to the twin who was cognitively normal...
June 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Audrey Giocanti-Auregan, Alain Gaudric, Frédérique Buffon, Manuele Mine, Corinne Delahaye-Mazza, Salomon Y Cohen, Ali Erginay, Hugues Chabriat, Elisabeth Tournier Lasserve, Valérie Krivosic
BACKGROUND AND OBJECTIVE: To analyze the location of familial retinal arterial tortuosity (fRAT) in the three-dimensional structure of retinal capillaries. PATIENTS AND METHODS: Retrospective observational study. Twelve eyes of six patients (two of whom were brothers) were imaged by optical coherence tomography angiography (OCTA). The data from their ocular and systemic examinations were recorded. RESULTS: OCTA imaging clearly showed increased tortuosity of second- and third-order retinal arteries in all cases, visible in the superficial vascular plexus (SVP) up to the arteriole termination in the capillaries...
June 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Michael J Heiferman, Emma J Griebenow, Manjot K Gill, Amani A Fawzi
BACKGROUND AND OBJECTIVE: Advanced retinal imaging can improve understanding of retinal vein occlusion (RVO) pathology. The authors aimed to characterize the vascular pathology of RVO on en face optical coherence tomography (OCT) and OCT angiography (OCTA). PATIENT AND METHODS: This was a cross-sectional study including 17 eyes with RVO. The authors identified discordance between vasculature on en face OCT and flow on OCTA, which was correlated with structural findings at the corresponding location on OCT B-scans...
June 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Takao Hirano, Karntida Chanwimol, Julian Weichsel, Tudor Tepelus, Srinivas Sadda
Optical coherence tomography angiography (OCTA) allows the retinal microvasculature to be visualized at various retinal depths. Previous studies introduced OCTA axial profile analysis and showed regional variations in the number and location of axially distinct vascular retinal plexuses. OCTA acquisition and processing approaches, however, vary in terms of their resulting transverse and axial resolutions, and especially the latter could potentially influence the profile analysis results. Our study imaged normal eyes using the Spectralis OCT2 with a full-spectrum, probabilistic OCTA algorithm, that, in marked contrast to split-spectrum approaches, preserves the original high OCT axial resolution also within the resulting OCTA signal...
June 20, 2018: Scientific Reports
Vivian Schreur, Artin Domanian, Bart Liefers, Freerk G Venhuizen, B Jeroen Klevering, Carel B Hoyng, Eiko K de Jong, Thomas Theelen
AIMS: To investigate retinal microaneurysms in patients with diabetic macular oedema (DME) by optical coherence tomography angiography (OCTA) according to their location and morphology in relationship to their clinical properties, leakage on fundus fluorescein angiography (FFA) and retinal thickening on structural OCT. METHODS: OCTA and FFA images of 31 eyes of 24 subjects were graded for the presence of microaneurysms. The topographical and morphological appearance of microaneurysms on OCTA was evaluated and classified...
June 20, 2018: British Journal of Ophthalmology
Akira Shiono, Jiro Kogo, Hiroki Sasaki, Ryo Yomoda, Tatsuya Jujo, Naoto Tokuda, Yasushi Kitaoka, Hitoshi Takagi
PURPOSE: To examine the relationship between optical coherence tomography (OCT) images and clinical course in eyes with branch retinal vein occlusion (BRVO) treated with intravitreal ranibizumab injection (IVR). DESIGN: Prospective cohort study. PARTICIPANTS: Thirty eyes of 30 patients with BRVO treated with IVR. METHODS: All patients received 1 initial IVR followed by repeated injections in the pro re nata (PRN) regimen...
2018: PloS One
Luis Filipe Nakayama, Vinicius Campos Bergamo, Leticia Sant'ana Cardoso Silva, Nilva Simeren Bueno Moraes
Here we report the case of a 78-year-old male patient with a 2-day history of low visual acuity and fundus and who was diagnosed with central retinal artery occlusion. In addition, the patient had an allergy to fluorescein. A fundus examination of the left eye found a pink optic disc with blurred margins, diffuse pallor in the retina with arterial attenuation, and a normal band of the retinal area in the macular region. Optical coherence tomography revealed increased thickness of the inner retina. Optical coherence tomography angiography (OCT-A) revealed a decreased flow signal in the superficial layers, with reduced flow signal in the choriocapillaris...
June 2018: Arquivos Brasileiros de Oftalmologia
Karlos Frederico Castelo Branco Sancho, Claudio Zett, Iran Gonçalves Júnior, Melina Correia Morales, Maurício Maia, Rubens Belfort Mattos Neto
PURPOSE: We aimed to evaluate the effects of oral propranolol for circumscribed choroidal hemangioma. METHODS: In this prospective, longitudinal interventional study, we administered oral propranolol at a dosage of 1.5 mg/kg/day to five patients with circumscribed choroidal hemangioma. We then evaluated visual acuity, binocular indirect ophthalmoscopy, optical coherence tomography, optical coherence tomography angiography, fluorescein and indocyanine green angiography, and ocular ultrasonography at regular intervals and compared changes from the baseline assessments...
June 2018: Arquivos Brasileiros de Oftalmologia
Danial Mohabati, Thomas J van Rijssen, Elon Hc van Dijk, Gregorius Pm Luyten, Tom O Missotten, Carel B Hoyng, Suzanne Yzer, Camiel Jf Boon
Purpose: The aim of this study was to investigate disease onset and disease progression in patients with severe chronic central serous chorioretinopathy (cCSC). Patients and methods: The medical records of 143 cCSC patients (199 eyes) were reviewed. All cases had visual complaints for >6 months and showed signs of a severe disease phenotype on optical coherence tomography (OCT) and fluorescein angiography (FA). Clinical presentation at onset was evaluated, together with disease progression on multimodal imaging and final treatment outcome...
2018: Clinical Ophthalmology
Raimondo Forte, Florent Aptel, Kim Thia-Soui-Tchong, Lenore Salmon, Adriane Mailhac, Laurence Bouillet, Christophe Chiquet
PURPOSE: To evaluate 2-year choroidal changes in eyes with birdshot retinochoroiditis (BRC). METHODS: Thirteen patients (26 eyes) with BRC were prospectively evaluated during a 2-year period with standard automated perimetry (SAP), fluorescein angiography, indocyanine green angiography and optical coherence tomography (Spectralis Heidelberg Retinal Angiograph + optical coherence tomography). Enhanced-depth imaging optical coherence tomography was performed. RESULTS: Eight patients (61%) were females; the patients mean age was 60 ± 4...
June 19, 2018: Ophthalmologica. Journal International D'ophtalmologie
Qian Wang, Szy Yann Chan, Yanni Yan, Jingyan Yang, Wenjia Zhou, Jost B Jonas, Wen Bin Wei
PURPOSE: To examine the vascular density in different retinal layers and in the choriocapillaris in eyes with retinal vein occlusions (RVO). METHODS: Applying optical coherence tomography angiography (OCTA), we examined patients with unilateral RVOs and normal individuals of a control group. RESULTS: The study group included 48 patients with unilateral RVO and the control group 17 normal individuals. Eyes affected by RVO as compared to the contralateral unaffected eyes (all P < 0...
June 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Chikako Hara, Taku Wakabayashi, Hiroshi Toyama, Yoko Fukushima, Kaori Sayanagi, Shigeru Sato, Hirokazu Sakaguchi, Kohji Nishida
PURPOSE: To investigate the frequency and patient characteristics that influence anatomic response of intravitreal aflibercept in treatment-naïve neovascular age-related macular degeneration (AMD). DESIGN: Retrospective, interventional, consecutive case series. METHODS: Three hundred and sixty-five eyes of 365 patients with AMD who underwent 3 monthly intravitreal aflibercept treatments with follow-up for at least 12 months were investigated...
June 15, 2018: British Journal of Ophthalmology
Mariana Ingolotti, Enrique Alfonso Roig Melo-Granados, Pedro Mario González-Madrigal, Humberto Ruiz García
PURPOSE: To report a case of central retinal artery occlusion in a patient with macular telangiectasia Type 2 using multimodal imaging. METHODS: Observational case report. RESULTS: A 58-year-old woman who presented with acute painless unilateral vision loss was diagnosed with central retinal artery occlusion in her right eye with macular telangiectasia Type 2 findings in both eyes. Fundus examination revealed retinal whitening with unusual cherry-red spot plus small crystalline deposits in the temporal macula...
June 13, 2018: Retinal Cases & Brief Reports
Thanos D Papakostas, Szilárd Kiss
No abstract text is available yet for this article.
June 14, 2018: JAMA Ophthalmology
Thomas S Hwang, Ahmed M Hagag, Jie Wang, Miao Zhang, Andrew Smith, David J Wilson, David Huang, Yali Jia
Importance: Diabetic retinopathy (DR) is a leading cause of vision loss that is managed primarily through qualitative clinical examination of the retina. Optical coherence tomography angiography (OCTA) may offer an objective and quantitative method of evaluating DR. Objective: To quantify capillary nonperfusion in 3 vascular plexuses in the macula of eyes patients with diabetes of various retinopathy severity using projection-resolved OCTA (PR-OCTA). Design, Setting, and Participants: Cross-sectional study at a tertiary academic center comprising 1 eye each from healthy control individuals and patients with diabetes at different severity stages of retinopathy...
June 14, 2018: JAMA Ophthalmology
Stephen Wai Luen Lee, Frankie C C Tam, Kelvin K W Chan, Simon C C Lam, Shun-Ling Kong, Catherine P Shea, Michael K L Wong, Anthony Y T Wong, Arthur S Y Yung, Li-Wei Zhang, Yui-Ming Lam, Gary S Mintz, Ricardo A Costa, Hans-Peter Stoll, Akiko Maehara
AIMS: In patients at high bleeding risk treated with 1 month of dual antiplatelet therapy, the polymer-free, biolimus A9-coated BioFreedom stent (BFS) was found safer and more efficacious than bare metal stents. We used sequential optical coherence tomography (OCT) to assess the time course of strut coverage and neointimal transformation from 1 to 9 months. METHODS AND RESULTS: We randomly assigned 104 BFS recipients to 1 of 5 groups with angiography and OCT follow-up at 1, 2, 3, 4, or 5 months, together with another follow-up for all at 9 months...
June 12, 2018: EuroIntervention
Kenji Sakamoto, Suguru Nagamatsu, Eiichiro Yamamoto, Koichi Kaikita, Kenichi Tsujita
In the past decades, coronary imaging has evolved as a valuable adjunct to angiography, providing scientific insights into vascular biology and practical guidance by direct visualization of atherosclerosis and other pathologic conditions within the vessel walls. Especially with intravascular ultrasound (IVUS), the signal is able to penetrate below the luminal surface, so the entire cross-section of an artery, including the complete thickness of the plaque, can be imaged in real-time. On the other hand, optical coherence tomography (OCT) has been offering higher image resolution of both the plaque and the luminal surface...
June 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Jing-Yu Min, Yanan Lv, Suqin Yu, Yuan-Yuan Gong
PURPOSE: The present study analyzed the appearances of optical coherence tomography angiography (OCTA) in patients with central serous chorioretinopathy (CSC) based on fluorescein angiography (FA) and indocyanine green angiography (ICGA). METHOD: In the current case series, 54 eyes of 50 patients diagnosed as CSC were evaluated retrospectively. OCTA, FA, and ICGA were performed on each patient. Two trained observers examined the OCTA images independently to confirm and compare the choriocapillary appearance with that on FA/ICGA...
June 12, 2018: Lasers in Surgery and Medicine
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