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https://www.readbyqxmd.com/read/29774177/the-new-direct-antiviral-agents-and-hepatitis-c-in-thoracic-transplantation-impact-on-donors-and-recipients
#1
REVIEW
Robert L Gottlieb, Shelley A Hall
Purpose of Review: The landscape of abdominal organ transplantation has been altered by the emergence of curative direct-acting antiviral agents for hepatitis C. Expansion of the thoracic donor pool to include the hearts and the lungs from hepatitis C-positive donors holds promise to increase available donor organs. Recent Findings: Case reports have documented separate lung and heart transplant patients who acquired, and then were cured of, donor-derived hepatitis C using these newer, more effective therapies...
2018: Current Transplantation Reports
https://www.readbyqxmd.com/read/29771247/-innovative-medicinal-products-the-new-criteria-of-the-italian-medicines-agency
#2
Federica Mammarella, Giovanni Tafuri
The Italian Medicines Agency (AIFA), which has the dual function of a regulatory and a reimbursement authority, has recently established new criteria to define innovative medicinal products. Indeed, the decision making process to grant the innovative status is based on the evaluation of the unmet medical need, the added therapeutic value compared to existing therapeutic options and the overall quality of clinical evidence, which is assessed based on the GRADE system. Following this evaluation, if a medicinal product is granted the status of "full innovativeness" for a specific therapeutic indication, its manufacturer can access dedicated yearly funds amounting to 500 million Euros each, depending on the type of medicine (one fund for oncology, the other for all other innovative medicinal products)...
May 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29751124/geopharmaceuticals-of-himalayan-sowa-rigpa-medicine-pharmacopoeial-description-geochemical-identification-their-diversity-and-current-utilization-in-bhutan
#3
Karma Yeshi, Phurpa Wangchuk
ETHNOPHARMACOLOGICAL RELEVANCE: Geological materials/minerals have been used in the Himalayan Sowa Rigpa and Bhutanese traditional medicine (BTM) for treating various disorders for thousands of years. AIM OF THE STUDY: Our study reports the chemical identification of various geological materials and their ethno-medicinal uses for the first time. MATERIALS AND METHODS: A five stage process was conducted including: (1) a survey of specialized ancient ethnomedical literatures (Pharmacopoeias and formularies); (2) freely listing the mineral ingredients reported in the ancient Sowa Rigpa medical texts and translating their ethnomedical uses in equivalent terms in English; (3) cross-checking the chemical names and chemical composition of identified minerals with various mineral databases and mineral handbooks; (4) Authentication and standardization of Sowa Rigpa names through open forum discussion with BTM practitioners; (5) further confirmation of the chemical names of identified minerals by consulting experts and pharmacognosist...
May 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29736940/growing-reinsurance-payments-weaken-competitive-bidding-in-medicare-part-d
#4
Jeah Jung, Roger Feldman
OBJECTIVES: To examine variation in risk-adjusted reinsurance payments across Part D plans, analyze its implications for the program, and explore options to reduce reinsurance payments. DATA/STUDY DESIGN: 2007-2015 Part D Plan Payment and Premium data; 2010-2013 Part D Prescription Drug Event data; and 2013 Part D Plan Formulary Files. PRINCIPAL FINDINGS: Risk-adjusted reinsurance payments varied widely across plans at a given out-of-pocket (OOP) premium...
May 7, 2018: Health Services Research
https://www.readbyqxmd.com/read/29736295/structural-confirmation-of-sulconazole-sulfoxide-as-the-primary-degradation-product-of-sulconazole-nitrate
#5
Qun Xu, Ashraf Khan, Di Gao, Kristie M Adams, Fatkhulla Tadjimukhamedov, Shane Tan, John T Simpson
Sulconazole has been reported to degrade into sulconazole sulfoxide via sulfur oxidation; however, structural characterization data was lacking and the potential formation of an N -oxide or sulfone could not be excluded. To clarify the degradation pathways and incorporate the impurity profile of sulconazole into the United States Pharmacopeia-National Formulary ( USP-NF ) monographs, a multifaceted approach was utilized to confirm the identity of the degradant. The approach combines stress testing of sulconazole nitrate, chemical synthesis of the degradant via a hydrogen peroxide-mediated oxidation reaction, semi-preparative HPLC purification, and structural elucidation by LC-MS/MS and NMR spectroscopy...
April 2018: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29735227/care-of-the-injured-patients-at-nursing-stations-and-during-air-medical-transport
#6
Brodie Nolan, Alun Ackery, Sol Mamakwa, Shari Glenn, David VanderBurgh, Aaron Orkin, Michael Kirlew, Evelyn Dell, Homer Tien
INTRODUCTION: Nursing stations are the only access point into the health care system for some communities and have limited capabilities and resources. We describe characteristics of patients injured in Northern Ontario who present to nursing stations and require transport by air ambulance. Secondary objectives are to compare interventions performed at nursing stations with those performed by flight paramedics and to identify systemic gaps in trauma care. METHODS: A retrospective cohort study was performed of all injured patients transported by air ambulance from April 1, 2014, to March 31, 2015...
May 2018: Air Medical Journal
https://www.readbyqxmd.com/read/29719371/p-t-committee-drug-prioritization-criteria-a-tool-developed-by-a-saudi-health-care-system
#7
Laila Carolina Abu Esba, Hind Almodaimegh, Ali Alhammad, Mazen Ferwana, Consuela Yousef, Sherine Ismail
Introduction: The workflow of a P&T committee can become overwhelming and may be affected by many internal and external factors. Organization, standardization, and an enhanced systematic approach for drug evaluations are necessary to ensure that all requested drugs receive an equal and unbiased evaluation and consideration for addition based on the institution's objectives, priorities, and budget. Our aim was to create a scoring tool that would assist in systematically prioritizing drugs being requested for formulary addition and to eliminate cumbersome evaluations for drugs that clearly do not offer any additional advantage...
May 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29714559/quality-of-medicine-information-in-product-information-leaflets-a-retrospective-audit
#8
M S S Saheeha, M H S Piumanthi, S P Perera, N R Samaranayake, G H Fernando
BACKGROUND: Nonstandard product information leaflets (PIs) may lead to medication errors. We assessed the completeness, and compatibility of, essential information against reference sources in selected PIs of medicines used in Sri Lanka. METHODS: Hundred PIs each were used to assess completeness and compatibility of information, respectively. Availability of essential information was checked against drug regulations of the country. Clinical facts were matched against the British National Formulary and/or Australian Medicines Handbook for compatibility...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29710007/-approach-to-practical-training-in-basic-clinical-pharmacy-for-third-year-pharmacy-students-literature-appraisal-and-professional-writing
#9
Ryuichi Ogawa
 Training pharmacy students to become future clinical pharmacists is an important mission in the 6-year school of pharmacy curriculum in Japan. Since 2014, we have conducted an on-campus practical training program to develop basic skills in clinical pharmacy for third-year pharmacy students at Meiji Pharmaceutical University. This training program includes searching for and retrieving drug information; interpretation of laboratory findings, vital signs, and physical examinations; literature appraisal; and professional writing...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29707225/a-quantitative-analysis-of-antipsychotic-prescribing-trends-for-the-treatment-of-schizophrenia-in-england-and-wales
#10
Rossela Roberts, Abigail Neasham, Chania Lambrinudi, Afshan Khan
Objective: This study aims to assess the current antipsychotic prescribing trends for the treatment of schizophrenia and to compare them with available guidelines and research evidence. Design: An observational retrospective quantitative analysis. Setting: Data were collected from the prescribing cost analysis for the period between 2007 and 2014, including all drugs from the British National Formulary 4.2.1 and 4.2.2. Prescriptions were included from primary and secondary healthcare settings in England and Wales...
April 2018: JRSM Open
https://www.readbyqxmd.com/read/29706116/approved-and-off-label-use-of-prescribed-psychotropic-medications-among-federal-canadian-inmates
#11
Gregory P Brown, Lynn A Stewart, Terry Rabinowitz, Harold Boudreau, Angela J Wright
OBJECTIVE: To examine psychotropic medication prescription practices in federal Canadian penitentiaries. METHOD: 468 files were drawn from a purposive sample of thirteen Canadian federal institutions representing the five regions, different security levels, and male and female designated facilities. Information on the names of all psychotropic medications prescribed, indications for use, dosage, frequency, and route of administration was retrieved. Designation of approved or off-label use of medications was determined by consulting: (1) the Health Canada (2016) Drug Product Database, (2) the Canadian Compendium of Pharmaceuticals and Specialties 2016, and (3) the American Hospital Formulary Service Drug Information 2016...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29705645/recent-pricing-negotiations-on-innovative-medicines-pilot-in-china-experiences-implications-and-suggestions
#12
Hong Li, Gordon G Liu, Jing Wu, Jiu-Hong Wu, Chao-Hui Dong, Shan-Lian Hu
The China National Formulary (CNF) for reimbursable drug use, also known as the National Reimbursement Drug List (NRDL), was formally established in 2000, revised in 2004 and 2009, and covers 52% of China's population under the government urban health insurance programs. A third major and long-awaited update to the formulary was completed in February 2017 based on intensive reviews by a group of experts in medicine, pharmacology, health economics, and health policy. Shortly after this major update, a pilot project at the central government level was implemented for negotiations mainly on innovative but expensive medicines that were still outside the National Formulary...
April 26, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29694285/real-world-health-care-costs-based-on-medication-adherence-and-risk-of-stroke-and-bleeding-in-patients-treated-with-novel-anticoagulant-therapy
#13
Chinmay G Deshpande, Stephen Kogut, Cynthia Willey
BACKGROUND: With the lack of real-world evidence, the challenge for drug reimbursement policy decision makers is to understand medication adherence behavior among users of novel oral anticoagulants (NOACs) and its effect on overall cost savings. No study has examined and quantified the burden of cost in high-risk patients taking NOAC therapy. OBJECTIVE: To examine the association of cost with adherence, comorbidity, and risk of stroke and bleeding in patients taking NOACs (rivaroxaban and dabigatran)...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29692934/a-web-based-platform-to-collect-data-from-esrd-patients-undergoing-dialysis-methods-and-preliminary-results-from-the-brazilian-dialysis-registry
#14
Jocemir R Lugon, Pedro A Gordan, Fernando S Thomé, Antonio A Lopes, Yoshimi J A Watanabe, Carmen Tzanno, Ricardo C Sesso
Introduction: The methods and initial results of a web-based platform to collect data from patients receiving maintenance dialysis in Brazil are reported. Methods: Companies providing management software for dialysis centers adapted their system to comply with a formulary of the Brazilian Society of Nephrology. Baseline and follow-up individual patients' data were transmitted via Internet on monthly bases to the coordinating center from 2011 to 2017. Results: 73 dialysis centers provided information of 24,930 patients: 57% were male, 28% were 64 years old or older, and 13% were overweight/obese...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29682790/trends-in-the-use-of-older-overactive-bladder-agents-and-uptake-of-fesoterodine-and-mirabegron-in-canada
#15
Rajwant Minhas, Mina Tadrous, Dean Elterman, Tara Gomes
AIMS: To examine early trends in the use of overactive bladder (OAB) agents across Canada, with a focus on initial uptake and reimbursement of two newer agents: fesoterodine, an anticholinergic, and mirabegron, a therapeutically novel beta-3 agonist. METHODS: We conducted a population-based cross-sectional study of outpatient prescriptions for long-acting oral OAB agents dispensed to individuals in Canada between May 2010 and April 2015 to examine the differences in the uptake of the newer agents and their reimbursement through cash, private, and public payers...
April 23, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29671627/the-impact-of-non-medical-switch-on-type-2-diabetes-patients-treated-with-canagliflozin-in-the-commercially-insured-us-population
#16
Lawrence Blonde, Chakkarin Burudpakdee, Victoria Divino, Brahim Bookhart, Jennifer Cai, Michael Pfeifer, Craig I Coleman
OBJECTIVE: To assess the impact of non-medical switch (NMS) from canagliflozin on antihyperglycemic agent (AHA) medication taking behavior. METHODS: This retrospective real-world database analysis included patients with type 2 diabetes with a prescription claim for canagliflozin between 8/2015 and 1/2016 using administrative claims and longitudinal prescription data. Patients with NMS from canagliflozin were identified as those with discontinuation or switch of canagliflozin and enrolled in a pharmacy benefit manager that removed CANA from formulary in 2016...
April 19, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29668645/coverage-of-medications-that-treat-opioid-use-disorder-and-opioids-for-pain-management-in-marketplace-plans-2017
#17
Haiden A Huskamp, Lauren E Riedel, Colleen L Barry, Alisa B Busch
BACKGROUND: Efficacious medications to treat opioid use disorders (OUDs) have been slow to diffuse into practice, and insurance coverage limits may be one important barrier. OBJECTIVES: To compare coverage for medications used to treat OUDs and opioids commonly prescribed for pain management in plans offered on the 2017 Health Insurance Marketplace exchanges. RESEARCH DESIGN: We identified a sample of 100 plans offered in urban and in rural counties on the 2017 Marketplaces, weighting by population...
April 17, 2018: Medical Care
https://www.readbyqxmd.com/read/29652559/point-prevalence-survey-of-antibiotic-use-and-resistance-at-a-referral-hospital-in-kenya-findings-and-implications
#18
Caleb Okoth, Sylvia Opanga, Faith Okalebo, Margaret Oluka, Amanj Baker Kurdi, Brian Godman
BACKGROUND AND AIMS: A substantial amount of antibiotic use in hospitals may be inappropriate, potentially leading to the development and spread of antibiotic resistance, adverse effects, mortality and increased hospital costs. The objective was to assess current patterns of antibiotic use in a leading referral hospital in Western Kenya. This would lead to the identification of opportunities for quality improvement in this hospital and across Kenya. METHODOLOGY: A point prevalence survey was carried out with data abstracted principally from patient medical records supplemented by interviews from physicians when needed...
April 13, 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29651437/questions-frequently-asked-of-healthcare-professionals-a-2-year-data-survey-conducted-at-a-medical-center
#19
Chi-Lien Hou, Ying-Hao Lu, Shun-Ching Chien, Hsu-Hui Chen, Chung-Yu Chen
In this descriptive, retrospective study, we analyzed the types of questions posed by healthcare professionals to drug counselors at a medical center and the types of provision of pharmaceutical advice solicited to improve pharmaceutical care quality and establish clear directions for clinical pharmacist training. We collected 8,558 questions posed by healthcare professionals (physicians, 38%; pharmacists, 39%; nurses, 23%) from the electronic drug information record system from May 2013 to April 2015 in one medical center...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29627770/essential-medicines-for-emergency-care-in-africa
#20
Morgan C Broccoli, Jennifer L Pigoga, Mulinda Nyirenda, Lee Wallis, Emilie J Calvello Hynes
OBJECTIVES: Essential medicines lists (EMLs) are efficient means to ensure access to safe and effective medications. The WHO has led this initiative, generating a biannual EML since 1977. Nearly all countries have implemented national EMLs based on the WHO EML. Although EMLs have given careful consideration to many public health priorities, they have yet to comprehensively address the importance of medicines for treating acute illness and injury. METHODS: We undertook a multistep consensus process to establish an EML for emergency care in Africa...
April 7, 2018: Emergency Medicine Journal: EMJ
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