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https://www.readbyqxmd.com/read/29149449/facing-more-hoops
#1
Joey Berlin
Opioid abuse has killed tens of thousands of Americans in recent years, prompting health plans to adjust their prescription drug policies, including changing formularies and prior-authorization processes.
November 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/29146489/exploring-the-barriers-to-and-facilitators-of-using-evidence-based-drugs-in-the-secondary-prevention-of-cardiovascular-diseases-findings-from-a-multistakeholder-qualitative-analysis
#2
Victoria Miller, Lavanya Nambiar, Malvika Saxena, Darryl Leong, Amitava Banerjee, José Pablo Werba, Jose Rocha Faria Neto, Katherine Curi Quinto, Mohammed Moniruzzaman, Shweta Khandelwal
BACKGROUND: Health-system barriers and facilitators associated with cardiovascular medication adherence have seldom been studied, particularly in low- and middle-income countries where uptake rates are poorest. OBJECTIVES: This study sought to explore the major obstacles and facilitators to the use of evidence-supported medications for secondary prevention of cardiovascular disease using qualitative analysis in 2 diverse countries across multiple levels of their health care systems...
November 13, 2017: Global Heart
https://www.readbyqxmd.com/read/29130272/effects-of-guideline-and-formulary-changes-on-statin-prescribing-in-the-veterans-affairs
#3
Adam A Markovitz, Rob G Holleman, Timothy P Hofer, Eve A Kerr, Mandi L Klamerus, Jeremy B Sussman
OBJECTIVE: To compare the effects of two sequential policy changes-the addition of a high-potency statin to the Department of Veterans Affairs (VA) formulary and the release of the American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines-on VA provider prescribing. DATA SOURCES/STUDY SETTING: Retrospective analysis of 1,100,682 VA patients, 2011-2016. STUDY DESIGN: Interrupted time-series analysis of changes in prescribing of moderate-to-high-intensity statins among high-risk patients and across high-risk subgroups...
December 2017: Health Services Research
https://www.readbyqxmd.com/read/29122794/consensus-validation-of-the-posamino-potentially-serious-alcohol-medication-interactions-in-older-adults-criteria
#4
Alice E Holton, Paul J Gallagher, Cristín Ryan, Tom Fahey, Gráinne Cousins
OBJECTIVES: Older adults are particularly vulnerable to adverse effects from concurrent alcohol and medication use. However, there is limited evidence regarding the prevalence of these adverse outcomes among older adults, and there is a lack of consensus regarding what constitutes an alcohol-interactive medicine. The objective of this study was to develop an explicit list of potentially serious alcohol-medication interactions for use in older adults. DESIGN: Following a systematic review, review of drug compendia and clinical guidance documents, a two-round Delphi consensus method was conducted...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29102325/surveillance-for-control-of-antimicrobial-resistance
#5
REVIEW
Evelina Tacconelli, Frangiscos Sifakis, Stephan Harbarth, Remco Schrijver, Maaike van Mourik, Andreas Voss, Mike Sharland, Nithya Babu Rajendran, Jesús Rodríguez-Baño
Antimicrobial resistance poses a growing threat to public health and the provision of health care. Its surveillance should provide up-to-date and relevant information to monitor the appropriateness of therapy guidelines, antibiotic formulary, antibiotic stewardship programmes, public health interventions, infection control policies, and antimicrobial development. In Europe, although the European Antimicrobial Resistance Surveillance Network provides annual reports on monitored resistant bacteria, national surveillance efforts are still fragmented and heterogeneous, and have substantial structural problems and issues with laboratory data...
October 25, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29100913/a-survey-of-caregivers-of-nigerian-children-less-than-6-years-of-age-to-determine-the-experience-and-perception-of-acceptability-of-oral-solid-dosage-forms
#6
Samuel Orubu, Chinyere Okwelogu, Olabisi Opanuga, Catherine Tuleu
OBJECTIVES: The World Health Organization (WHO) recommends flexible solid oral dosage forms such as dispersible tablet as the preferred formulation for (young) children, especially in developing/low- and middle-income countries, LMIC. The aim of this study was to assess experience, perceptions of acceptability, and formulation preferences, among 10 oral dosage forms for young children in a sample of end-users in Nigeria as an exemplar LMIC. METHODS: Using a semi-structured and validated questionnaire, 148 caregivers were surveyed...
October 31, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29092059/medication-related-clinical-decision-support-alert-overrides-in-inpatients
#7
Karen C Nanji, Diane L Seger, Sarah P Slight, Mary G Amato, Patrick E Beeler, Qoua L Her, Olivia Dalleur, Tewodros Eguale, Adrian Wong, Elizabeth R Silvers, Michael Swerdloff, Salman T Hussain, Nivethietha Maniam, Julie M Fiskio, Patricia C Dykes, David W Bates
Objective: To define the types and numbers of inpatient clinical decision support alerts, measure the frequency with which they are overridden, and describe providers' reasons for overriding them and the appropriateness of those reasons. Materials and Methods: We conducted a cross-sectional study of medication-related clinical decision support alerts over a 3-year period at a 793-bed tertiary-care teaching institution. We measured the rate of alert overrides, the rate of overrides by alert type, the reasons cited for overrides, and the appropriateness of those reasons...
October 27, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29089796/impact-of-the-pan-canadian-oncology-drug-review-on-provincial-concordance-with-respect-to-cancer-drug-funding-decisions-and-time-to-funding
#8
A Srikanthan, H Mai, N Penner, E Amir, A Laupacis, M Sabharwal, K K W Chan
BACKGROUND: The pan-Canadian Oncology Drug Review (pcodr) was implemented in 2011 to address uneven drug coverage and lack of transparency with respect to the various provincial cancer drug review processes in Canada. We evaluated the impact of the pcodr on provincial decision concordance and time from Notice of Compliance (noc) to drug funding. METHODS: In a retrospective review, Health Canada's Drug Product Database was used to identify new indications for cancer drugs between January 2003 and May 2014, and provincial formulary listings for drug-funding dates and decisions between 1 January 2003 and 31 December 2014 were retrieved...
October 2017: Current Oncology
https://www.readbyqxmd.com/read/29074147/cost-savings-impact-of-a-pharmacist-initiated-teleservice-program-for-medicare-part-d-reviews
#9
Colleen Massey, Timothy Dy Aungst, Paula Evans, Donna Bartlett, Matthew A Silva
OBJECTIVES: To (a) determine potential cost savings of a pharmacy outreach teleservice program conducting Medicare Part D plan reviews for a large population of beneficiaries allowing for comparison of multiple preferences; and (b) explore client demographic comparisons, plan features, and stratification by cost and number of medications. METHODS: Retrospective cohort evaluation of a Medicare D review service during open enrollment period (October 15 to December 7, 2012)...
October 23, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29073981/applying-multi-criteria-decision-analysis-mcda-simple-scoring-as-an-evidence-based-hta-methodology-for-evaluating-off-patent-pharmaceuticals-opps-in-emerging-markets
#10
Diana Brixner, Nikos Maniadakis, Zoltán Kaló, Shanlian Hu, Jie Shen, Kalman Wijaya
Off-patent pharmaceuticals (OPPs) represent more than 60% of the pharmaceutical market in many emerging countries, where they are frequently evaluated primarily on cost rather than with health technology assessment. OPPs are assumed to be identical to the originators. Branded and unbranded generic versions can, however, vary from the originator in active pharmaceutical ingredients, dosage, consistency formulation, excipients, manufacturing processes, and distribution, for example. These variables can alter the efficacy and safety of the product, negatively impacting both the anticipated cost savings and the population's health...
September 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29063523/evaluation-of-existing-and-desired-antimicrobial-stewardship-activities-and-strategies-in-swiss-hospitals
#11
M Osthoff, Julia Belicki, Andreas F-X Widmer, For Swissnoso
Antimicrobial stewardship (AMS) is an important component in the fight against antimicrobial resistance. Currently, few hospitals have an ongoing institutional AMS programme. Swissnoso - the national centre for infection prevention - has launched a national Swiss AMS initiative supported by the office of public health. To guide AMS priorities and resources, current AMS activities in Switzerland were assessed. We distributed an internet-based questionnaire directed mainly to board-certified infectious diseases specialists and, if not available, senior internal medicine staff...
October 24, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29063149/primary-care-physicians-report-high-trust-in-and-usefulness-of-the-stockholm-drug-and-therapeutic-committee-s-list-of-recommended-essential-medicines-the-wise-list
#12
Jaran Eriksen, Marie-Louise Ovesjö, Martina Vallin, Maria Juhasz-Haverinen, Eva Andersén-Karlsson, Kristina Ateva, Lars L Gustafsson, Malena Jirlow, Pia Bastholm-Rahmner
PURPOSE: Inappropriate use of medicines causes increased morbidity, mortality, adverse drug reactions, therapeutic failures and drug resistance as well as wastes valuable resources. Evidence-based cost-effective treatment recommendations of essential medicines are a way of avoiding these. We assessed primary care prescribers' knowledge about and perceptions of an essential medicines formulary, as well as the reasons for adhering to the recommendations. METHODS: We conducted a web based questionnaire survey targeting all physicians working in the primary healthcare of the Stockholm healthcare region (2...
October 23, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29061631/drug-approval-status-and-recommendations-for-listing-on-public-formularies-a-canadian-cohort-analysis
#13
Joel Lexchin
OBJECTIVES: Investigate if the recommendations by the Common Drug Review (CDR) and the pan-Canadian Oncology Drug Review (pCODR) to provincial, territorial and federal drug plans about whether to list non-oncology and oncology drug-indication combinations on their formularies are associated with whether the drug-indication combination was approved via the standard evidence pathway or the Notice of Compliance with conditions (NOC/c-limited evidence) pathway. DESIGN: Cohort study...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29052693/medicare-formulary-coverage-restrictions-for-prescription-opioids-2006-to-2015
#14
Elizabeth A Samuels, Joseph S Ross, Sanket S Dhruva
No abstract text is available yet for this article.
October 10, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29050762/whole-genome-sequencing-for-the-management-of-drug-resistant-tb-in-low-income-high-tb-burden-settings-challenges-and-implications
#15
REVIEW
Sharana Mahomed, Kogieleum Naidoo, Navisha Dookie, Nesri Padayatchi
Drug-resistant tuberculosis is emerging as a major global health challenge, fuelled by a limited formulary and reduced ability to timeously diagnose resistance. Furthermore, poorly managed drug-resistant tuberculosis is complicated by poor treatment outcomes and high rates of morbidity and mortality. A rapid diagnosis together with individualized management are essential in order to limit disease and curtail transmission. Recently, the feasibility of Whole Genome Sequencing (WGS) technology for the routine diagnosis and drug susceptibility testing of Mycobacterium Tuberculosis in a high income, low tuberculosis burden setting, was demonstrated...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29049325/effect-of-therapeutic-interchange-on-medication-reconciliation-during-hospitalization-and-upon-discharge-in-a-geriatric-population
#16
Jessica S Wang, Robert L Fogerty, Leora I Horwitz
BACKGROUND: Therapeutic interchange of a same class medication for an outpatient medication is a widespread practice during hospitalization in response to limited hospital formularies. However, therapeutic interchange may increase risk of medication errors. The objective was to characterize the prevalence and safety of therapeutic interchange. METHODS AND FINDINGS: Secondary analysis of a transitions of care study. We included patients over age 64 admitted to a tertiary care hospital between 2009-2010 with heart failure, pneumonia, or acute coronary syndrome who were taking a medication in any of six commonly-interchanged classes on admission: proton pump inhibitors (PPIs), histamine H2-receptor antagonists (H2 blockers), hydroxymethylglutaryl CoA reductase inhibitors (statins), angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and inhaled corticosteroids (ICS)...
2017: PloS One
https://www.readbyqxmd.com/read/29046178/a-psychiatric-formulary-for-long-duration-spaceflight
#17
Eric Friedman, Brian Bui
Behavioral health is essential for the safety, well-being, and performance of crewmembers in both human spaceflight and Antarctic exploration. Over the past five decades, psychiatric issues have been documented in orbital spaceflight. In Antarctica, literature suggests up to 5% of wintering crewmembers could meet criteria for a psychiatric illness, including mood disorders, stressor-related disorders, sleep-wake disorders, and substance-related disorders. Experience from these settings indicates that psychiatric disorders on deep space missions must be anticipated...
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29046089/the-hidden-cost-of-deep-neck-space-infectionsy
#18
R H Hurley, C M Douglas, J Montgomery, L J Clark
Introduction The incidence of deep neck space infection (DNSI) is rising and appears to be related to falling rates of tonsillectomy. The purpose of this study was to assess demographics of patients presenting with DNSI and the financial burden to the National Health Service (NHS). Methods Data were collected retrospectively on patients aged over 16 years admitted to NHS Greater Glasgow and Clyde with DNSI between 2012 and 2016. Demographics, aetiology and use of hospital resources were reviewed. The cost of hospital admissions was calculated using data from NHS Scotland's Information Services Division, the local diagnostics division and the British National Formulary...
October 19, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29028123/impact-of-insulin-detemir-administration-time-on-hypoglycemia-rates-in-hospitalized-patients
#19
Jennifer L Grelle, Sydney N Kutter, Megan E Giruzzi, John C Tawwater
STUDY OBJECTIVE: To determine if insulin detemir administration time affects the frequency of hypoglycemia (blood glucose level <70 mg/dL) in hospitalized patients. DESIGN: Retrospective cohort study. PATIENTS: A total of 357 adults (aged 18-89 yrs) who received insulin detemir for at least 48 hours while hospitalized between January 1, 2014, and December 31, 2015, were included. Patients were categorized into one of three groups according to insulin detemir administration time: detemir given once daily between 7 A...
October 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29018301/a-p-t-committee-s-transition-to-a-complete-electronic-meeting-system-a-multisite-institution-experience
#20
Ahmed H Al-Jedai, Roaa A Algain, Said A Alghamidi, Abdulrazaq S Al-Jazairi, Rashid Amin, Ibrahim Z Bin Hussain
PURPOSE: In the last few decades, changes to formulary management processes have taken place in institutions with closed formulary systems. However, many P&T committees continued to operate using traditional paper-based systems. Paper-based systems have many limitations, including confidentiality, efficiency, open voting, and paper wastage. This becomes more challenging when dealing with a multisite P&T committee that handles formulary matters across the whole health care system. In this paper, we discuss the implementation of the first paperless, completely electronic, Web-based formulary management system across a large health care system in the Middle East...
October 2017: P & T: a Peer-reviewed Journal for Formulary Management
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