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https://www.readbyqxmd.com/read/27754250/os-36-01-hcarg-improves-tissue-repair-after-renal-injury-by-regulating-egfr-signaling
#1
Johanne Tremblay, Carole G Campion, Thomas Verissimo, Suzanne Cossette, Hiroyuki Matsuda, Pavel Hamet
OBJECTIVE: Epidermal growth factor receptor (EGFR) signaling plays a dual role in hypertension-induced kidney damage. EGFR is critically involved in angiotensin II-induced renal lesions and fibrosis but is also engaged in kidney tissue repair. Consequently, targeting EGFR in renal diseases is complex because even if inhibition of EGFR activity would be beneficial, a minimal EGFR activity is needed to recover from harmful insults. Our group has identified HCaRG (Hypertension-related, Calcium-Regulated Gene) whose expression is increased in kidneys of hypertensive rats and mice...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643215/os-36-01-hcarg-improves-tissue-repair-after-renal-injury-by-regulating-egfr-signaling
#2
Johanne Tremblay, Carole G Campion, Thomas Verissimo, Suzanne Cossette, Hiroyuki Matsuda, Pavel Hamet
OBJECTIVE: Epidermal growth factor receptor (EGFR) signaling plays a dual role in hypertension-induced kidney damage. EGFR is critically involved in angiotensin II-induced renal lesions and fibrosis but is also engaged in kidney tissue repair. Consequently, targeting EGFR in renal diseases is complex because even if inhibition of EGFR activity would be beneficial, a minimal EGFR activity is needed to recover from harmful insults. Our group has identified HCaRG (Hypertension-related, Calcium-Regulated Gene) whose expression is increased in kidneys of hypertensive rats and mice...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26045088/jasn-s-silver-jubilee
#3
EDITORIAL
Karl A Nath, Eric G Neilson, William G Couser, C Craig Tisher, Jared J Grantham
No abstract text is available yet for this article.
July 2015: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/25401126/seasonality-of-water-chemistry-carbonate-production-and-biometric-features-of-two-species-of-chara-in-a-shallow-clear-water-lake
#4
Andrzej Pukacz, Mariusz Pełechaty, Marcin Frankowski, Artur Kowalski, Kinga Zwijacz-Koszałka
The objective of this study was to analyze the temporal variability of biometric features and the carbonate production of two charophytes: Chara polyacantha A. Braun and Chara rudis A. Braun against the background of the physical-chemical properties of water. The investigation was carried out in a small, mid-forest Lake Jasne (western Poland). It is a polymictic, mesotrophic, hardwater ecosystem dominated by charophyte vegetation. Each month, 10 individuals of each species were characterized in terms of morphometric features, fresh and dry weight, and the percentage of calcium carbonate...
2014: TheScientificWorldJournal
https://www.readbyqxmd.com/read/23197555/the-ultrasound-challenge-a-novel-approach-to-medical-student-ultrasound-education
#5
David P Bahner, Adam Jasne, Stacy Boore, Anthony Mueller, Eric Cortez
Undergraduate ultrasound education is becoming increasingly important to medical student development; as a result, innovative training methods are being designed and implemented. The Ultrasound Challenge was created to help students learn core ultrasound techniques and apply them in a friendly competition where they showcase their abilities. The Ultrasound Challenge consisted of 6 events: focused assessment with sonography for trauma, cardiac ultrasound, aortic ultrasound, pelvic ultrasound, vascular access, and musculoskeletal ultrasound...
December 2012: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/21852583/effect-of-recommendations-from-reviewers-suggested-or-excluded-by-authors
#6
Jessica L Moore, Eric G Neilson, Vivian Siegel
The Journal of the American Society of Nephrology (JASN) gives authors submitting original research the option of suggesting qualified reviewers or those they wish to exclude. This historical habit often leaves us wondering whether author preferences correlate with reviewer recommendations and whether differences related to reviewer selection affect decisions by editors. In a self-study presented here, we found that author-suggested reviewers, as a group, make more positive recommendations than editor-suggested reviewers (P = 0...
September 2011: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/20625086/imaging-cortical-lesions-in-multiple-sclerosis-with-ultra-high-field-magnetic-resonance-imaging
#7
David Pitt, Aaron Boster, Wei Pei, Eric Wohleb, Adam Jasne, Cherian R Zachariah, Kottil Rammohan, Michael V Knopp, Petra Schmalbrock
OBJECTIVE: To determine the sensitivity of T2*-weighted gradient-echo (T2*GRE) and inversion recovery turbo-field-echo (TFE) sequences for cortical multiple sclerosis lesions at 7 T. DESIGN, SETTING, AND PARTICIPANTS: Autopsied brain tissue from individuals with multiple sclerosis was scanned with 3-dimensional T2*GRE and 3-dimensional inversion recovery white matter-attenuated TFE sequences at 7 T. Cortical lesions visible with either sequence were scored for each anatomical lesion type...
July 2010: Archives of Neurology
https://www.readbyqxmd.com/read/20007749/the-birth-and-early-development-of-jasn
#8
EDITORIAL
Jared J Grantham, Lawrence P Sullivan
No abstract text is available yet for this article.
January 2010: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/18515655/activation-of-hypoxia-inducible-factors-ameliorates-hypoxic-distal-tubular-injury-in-the-isolated-perfused-rat-kidney
#9
Christian Rosenberger, Seymour Rosen, Ahuva Shina, Ulrich Frei, Kai-Uwe Eckardt, Lee A Flippin, Michael Arend, Stephen J Klaus, Samuel N Heyman
BACKGROUND: Preconditional activation of HIF with specific prolyl-hydroxylase inhibitors (PHD-I) attenuates proximal tubular injury, induced by warm ischaemia/ reperfusion (Bernhardt, JASN, 2006). Distal tubular damage occurs in humans with acute kidney injury (AKI), in experimental contrast media-induced nephropathy (CIN), as well as in cell-free isolated perfused kidneys (IPKs). Since in the IPK distal tubular damage inversely correlates with HIF activation (Rosenberger, KI, 2005), we explored the potential of PHD-I to improve morpho-functional outcome in this model...
November 2008: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/16820371/dna-polymorphisms-and-renal-disease-a-critical-appraisal-of-studies-presented-at-the-annual-era-edta-and-asn-conferences-in-2004-and-2005
#10
Adrian Mondry, Marie Loh, Kevin Ben Laurence, Nelson Low
Countless studies try to associate single DNA polymorphisms with disease, while there is growing evidence that many of these studies are of flawed design. Based on the Journal of the American Society of Nephrology (JASN) requirements for gene-disease association study quality, the abstracts presented at the two major international nephrology conferences in 2004 and 2005 organized by the European Renal Association/European Dialysis and Transplantation Association (ERA/EDTA) and American Society of Nephrology (ASN) are analysed to show how this problem affects nephrology...
October 2006: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/12373077/renal-and-intestinal-handling-of-oxalate-following-oxalate-loading-in-rats
#11
Marguerite Hatch, Robert W Freel
BACKGROUND: The enteric excretion of oxalate has been established in rats with chronic renal failure induced by 5/6 nephrectomy [Hatch et al.: Regulatory aspects of oxalate secretion in enteric oxalate elimination. JASN 1999;10:S324] and this response is mediated by angiotensin II receptor activation. However, the renal and intestinal handling of oxalate has not been evaluated for other common models of hyperoxaluria that simulate primary hyperoxaluria or oxalate stone disease. METHODS: We assessed the renal clearances of creatinine, oxalate and calcium in three rat models: chronic hyperoxaluria (CH), chronic hyperoxaluria with hyperoxalemia (CHH) and acute hyperoxaluria (AH), and evaluated the transepithelial transport of oxalate and chloride in large intestinal segments of these models and their sensitivity to angiotensin II antagonism...
January 2003: American Journal of Nephrology
https://www.readbyqxmd.com/read/6409899/altered-cytochrome-p-450-in-a-yeast-mutant-blocked-in-demethylating-c-32-of-lanosterol
#12
Y Aoyama, Y Yoshida, S Hata, T Nishino, H Katsuki, U S Maitra, V P Mohan, D B Sprinson
Spectroscopic and enzymatic analysis of a Saccharomyces cerevisiae mutant in sterol biosynthesis (SG1 (erg 11); Trocha, P. J., Jasne, S. J., and Sprinson, D. B. (1977) Biochemistry 16, 4721-4726) that was blocked in demethylating C-32 of lanosterol (4,4,14 alpha-trimethyl-5 alpha-cholesta-8,24-dien-3 beta-ol) showed that it contained low levels of cytochromes P-450 and b5 compared to those present in the parent strain D-587, while NADPH-cytochrome c reductase activity was elevated. The fungicide buthiobate (S-n-butyl S'-p-tert-butylbenzyl N-3-pyridyldithiocarbonimidate), which bound specifically to yeast cytochrome P450 responsible for demethylating C-32 of lanosterol and effected a Type II spectral change, did not react with SG1 cytochrome P-450...
August 10, 1983: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/6209933/chitynolytic-bacteria-in-water-and-bottom-sediments-of-two-lakes-of-different-trophy
#13
COMPARATIVE STUDY
W Donderski
Chitynolytic bacteria were found in greater numbers in the eutrophic lake Jeziorak than in the mesotrophic lake Jasne. In both lakes higher chitynolytic activity was found in the planktonic than in the benthic bacteria. The capacity of chitin hydrolysis was found in bacteria of the genera Achromobacter, Bacillus, Nocardia, Pseudomonas, of the Flavobacterium-Cytophaga group and of the Enterobacteriaceae family. The chitinases synthesized by the studied bacteria were active in the pH range 5.0--8.0. The majority of the strains tested showed maximum activity at pH 5...
1984: Acta Microbiologica Polonica
https://www.readbyqxmd.com/read/4604829/novel-sterols-in-ergosterol-deficient-yeast-mutants
#14
COMPARATIVE STUDY
P J Trocha, S J Jasne, D B Sprinson
No abstract text is available yet for this article.
July 24, 1974: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/2104258/determinants-of-epithelial-differentiation-during-early-nephrogenesis
#15
REVIEW
B M Brenner
Organogenesis from undifferentiated progenitor cells and initiation of a society's new journal are developmental processes which share common elements. Both initially require a potent inducing stimulus followed in relatively rapid sequence by the appearance of organ-specific differentiation markers. These events are prerequisites to subsequent proliferation and maturation. Insofar as many postnatal forms of renal disease (e.g., hereditary glomerulopathies, infantile and adult forms of polycystic kidney disease, congenital dysplasias) owe their origins ultimately to disordered nephrogenesis, it is my belief that research in this area of nephrology should expand...
August 1990: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/334248/yeast-mutants-blocked-in-removing-the-methyl-group-of-lanosterol-at-c-14-separation-of-sterols-by-high-pressure-liquid-chromatography
#16
P J Trocha, S J Jasne, D B Sprinson
Sterols of a nystatin resistant mutant of the wild type parent of Saccharomyces cerevisiae were separated by a newly developed procedure involving high-pressure liquid chromatography and were identified. The mutant contained larger amounts of squalene and lanosterol (I) than the wild type, as well as 4,14-dimethylcholesta-8,24-dien-3beta-ol (II), 4,14-dimethylergosta-8,24(28)-dien-3beta-ol (III), and 14-methylergosta-8,24(28)-dien-3beta-ol (IV), which were not hitherto found in yeast. These results indicated a block in removal of the methyl group at C-14 of lanosterol...
October 18, 1977: Biochemistry
https://www.readbyqxmd.com/read/67759/dehydrogenase-activity-in-the-bottom-sediments-of-three-lakes
#17
W Donderski, M Stopiński
Dehydrogenase activity was studied in the sediments of three lakes of the Iława Lakeland (Jeziorak, Mały Jeziorak and Jasne) with reference to the type of lake, the season of the year, the situation of the sediments, pH and temperature. The highest activity was found in the sediments of the eutrophic lake Jeziorak sampled during the summer from places in the vicinity of a village. The lowest activity was exhibited by sediments sampled in the autumn in the lakes Jasne and Mały Jeziorak. No correlation was found between dehydrogenase activity and the number of bacteria in the sediments...
1977: Acta Microbiologica Polonica
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