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https://www.readbyqxmd.com/read/29778973/a-two-fatal-cases-of-poisoning-involving-new-cathinone-derivative-pv8
#1
Ewelina Pieprzyca, Rafał Skowronek, Małgorzata Korczyńska, Joanna Kulikowska, Małgorzata Chowaniec
α-Pyrrolidinoheptiophenone (PV8) is a representative of α-pyrrolidinophenone derivatives, a new group of synthetic cathinones. PV8 was first detected in illegal products in Japan in 2013. It is closely related to α-pyrrolidinovalerophenone (α-PVP), which was one of the most popular novel psychoactive substance (NPS) in Poland in years 2013-2015. The article presents two cases of fatal poisonings of 36-year-old man and 37-year-old woman, where a new cathinone derivative - PV8 was detected in biological material collected during medicolegal autopsies...
May 14, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29778950/efficacy-of-educational-intervention-to-improve-awareness-of-the-importance-of-iodine-use-of-iodized-salt-and-dietary-iodine-intake-in-northeastern-italian-schoolchildren
#2
Sara Watutantrige-Fernando, Susi Barollo, Loris Bertazza, Elisabetta Cavedon, Simona Censi, Jacopo Manso, Federica Vianello, Caterina Mian
OBJECTIVE: An educational program was conducted among school-aged children to improve their knowledge about iodine prophylaxis, their iodine status, and their dietary habits. METHODS: At the baseline (T0) and after 6 mo (T1), participants (970 at T0 and 949 at T1) answered questionnaires testing their knowledge about iodine prophylaxis and their eating habits. Urine samples were collected from a randomly selected subgroup of participants (313 at T0 and 312 at T1)...
March 23, 2018: Nutrition
https://www.readbyqxmd.com/read/29778832/glucocorticoid-metabolites-in-newborns-a-marker-for-traffic-noise-related-stress
#3
Manuella Lech Cantuaria, Jakob Usemann, Elena Proietti, Victoria Blanes-Vidal, Bernhard Dick, Christa E Flück, Simone Rüedi, Harris Héritier, Jean-Marc Wunderli, Philipp Latzin, Urs Frey, Martin Röösli, Danielle Vienneau
BACKGROUND: Traffic noise has been associated with an increased risk for several non-auditory health effects, which may be explained by a noise-induced release of stress hormones (e.g. glucocorticoids). Although several studies in children and adults have indicated an increased secretion of glucocorticoids after exposure to noise, information regarding newborns is scarce. OBJECTIVES: To investigate the association between residential exposure to road traffic noise and postnatal stress response, as assessed by the concentration of glucocorticoids at five weeks of age...
May 17, 2018: Environment International
https://www.readbyqxmd.com/read/29778814/environmental-and-lifestyle-factors-affecting-exposure-to-polycyclic-aromatic-hydrocarbons-in-the-general-population-in-a-middle-eastern-area
#4
Mohammad Hoseini, Ramin Nabizadeh, Juana Maria Delgado-Saborit, Ata Rafiee, Kamyar Yaghmaeian, Saeid Parmy, Sasan Faridi, Mohammad Sadegh Hassanvand, Masud Yunesian, Kazem Naddafi
The aim of this study was to investigate environmental and lifestyle factors affecting exposure to PAHs in the general population in a large city of the Middle East (Tehran) by measuring urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) and establishing relationships between PAHs exposure and related factors. Urine samples were collected from 222 randomly chosen subjects who were living in the urban area of Tehran, Iran. Subjects were required to complete a detailed questionnaire aimed to document their personal and sociodemographic information, activities, cooking-related appliances, smoking history/exposure, and consumed foodstuff...
May 17, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29778398/antipsychotic-induced-disorders-reported-cases-and-prospective-study-on-muscle-biomarkers-after-high-exposure-to-haloperidol
#5
Abderrezak Khelfi, Mohammed Azzouz, Rania Abtroun, Mohammed Reggabi, Berkahoum Alamir
Antipsychotic drugs are known to induce neuromuscular effects. In this study, we review 13 years (2002-2014) of antipsychotic intoxications reported by the anti-poisoning center of Algiers (APCA). The most recorded symptoms were neuromuscular/muscular disorders, of which haloperidol was the most inducer among all antipsychotics. A prospective study was conducted between December 2012 and January 2017 to evaluate muscle effects generated after intentional or accidental ingestion of haloperidol. Fifty-one patients admitted in different emergency departments in Algiers were included in this study...
May 17, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29778152/occurrence-of-perfluoroalkyl-substances-in-matched-human-serum-urine-hair-and-nail
#6
Yuxin Wang, Yuxin Zhong, Jingguang Li, Jianqing Zhang, Bing Lyu, Yunfeng Zhao, Yongning Wu
The purpose of this study was to determine perfluoroalkyl substances (PFASs) in human serum, urine, hair and nail from general populations, and to investigate the possibility for human urine, hair and nail used as the biomonitoring sample for PFASs exposure. We detected the concentrations of PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoA, PFHxS and PFOS in 39 matched human serum, urine, hair and nail samples from Shenzhen in China. The detection frequency and the median level of PFOS were all higher than that of the other PFASs in four matrices...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29778011/bisphenol-a-exposure-through-receipt-handling-and-its-association-with-insulin-resistance-among-female-cashiers
#7
Inae Lee, Sunmi Kim, Ki-Tae Kim, Sungkyoon Kim, Suhyun Park, Hyojin Lee, Yunsun Jeong, Jae-Eun Lim, Hyo-Bang Moon, Kyungho Choi
Bisphenol A (BPA) is one of the most widely used chemicals in various consumer products. In thermal papers such as receipts and tickets, BPA is used as a heat-activated developer. Cashiers are therefore suspected to be a vulnerable group of exposure to BPA, but neither contribution of receipt handling to the total body burden of BPA among cashiers, nor related health effects are well characterized. Female cashiers (n = 54) were recruited from seven retail shops of a major supermarket chain in Korea, and urinary levels of BPA and metabolic syndrome (MetS) related biomarkers were measured...
May 16, 2018: Environment International
https://www.readbyqxmd.com/read/29778003/highly-efficient-electrochemical-determination-of-propylthiouracil-in-urine-samples-after-selective-electromembrane-extraction-by-copper-nanoparticles-decorated-hollow-fibers
#8
Zeinab Tahmasebi, Saied Saeed Hosseiny Davarani, Ali Akbar Asgharinezhad
In this work, a novel, inexpensive and fast strategy was described for selective and effective extraction and determination of propylthiouracil (PTU) with a high polarity (log P = 1.2) based on electromembrane extraction (EME) followed by differential pulse voltammetry (DPV). For this purpose, copper nanoparticles (CuNPs)-decorated hollow fiber was used as the selective membrane for EME of PTU in urine samples. The influential parameters on extraction such as extraction solvent, pH, agitation speed, applied potential and extraction time were systematically investigated...
May 9, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29777551/a-new-method-for-quantitative-determination-of-renalase-based-on-mass-spectrometry-determination-of-a-proteotypic-peptide-labeled-with-stable-isotopes
#9
A T Kopylov, V I Fedchenko, O A Buneeva, N V Pyatakova, V G Zgoda, A E Medvedev
RATIONALE: Renalase is a recently discovered kidney secretory protein, which is considered as an important component involved in blood pressure regulation. Although altered levels of renalase have been detected in plasma and urine of patients with various kidney diseases, there is certain inconsistency of changes in the renalase levels reported by different laboratories. The latter is obviously associated with the use of ELISA as the only available approach for quantitative analysis of renalase...
May 18, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29777094/biological-monitoring-and-lung-function-assessment-among-workers-exposed-to-chromium-in-the-ceramic-industry
#10
Fatemeh Kargar Shouroki, Seyed Jamaleddin Shahtaheri, Farideh Golbabaei, Abolfazle Barkhordari, Abbas Rahimi-Froushani
BACKGROUND: Chromium exposure occurs in various industries such as ceramics industry. The main disadvantage of chromium is high toxicity when absorbed by the body. This study aimed to determine and compare urinary chromium values in the pre- and post-shift of ceramic glazers and the control group; investigate urinary chromium value according to the study variables; compare pulmonary function tests between ceramic glazers vs. the control group. STUDY DESIGN: A cross-sectional study...
March 19, 2018: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/29775445/the-clinical-pattern-of-nephrotic-syndrome-in-children-has-no-effect-on-the-concentration-of-soluble-urokinase-receptor-supar-in-serum-and-urine
#11
Agnieszka Ochocińska, Wioletta Jarmużek, Roman Janas
Concentration of soluble urokinase receptor (suPAR) was regarded as viable marker to differentiate the focal segmental glomerulosclerosis (FSGS) from other glomerulopathies and also as predictive parameter for progression of renal disease. AIM: The aim of this study was to evaluate serum and urine (s)(u)suPAR concentration in steroid-sensitive and steroid-resistant nephrotic children treated with different (double and triple-drug) regimens. MATERIALS AND METHODS: Overall 43 children were evaluated including 14 patients with steroid-resistant nephrotic syndrome (SRNS) aged 9±6 years and 29 with steroid-sensitive nephrotic syndrome (SSNS) aged 9±5 years, as well as control group (n=59)...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29774300/epidemiology-of-intestinal-parasite-infections-in-three-departments-of-south-central-c%C3%A3-te-d-ivoire-before-the-implementation-of-a-cluster-randomised-trial
#12
Gaoussou Coulibaly, Mamadou Ouattara, Kouassi Dongo, Eveline Hürlimann, Fidèle K Bassa, Naférima Koné, Clémence Essé, Richard B Yapi, Bassirou Bonfoh, Jürg Utzinger, Giovanna Raso, Eliézer K N'Goran
Hundreds of millions of people are infected with helminths and intestinal protozoa, particularly children in low- and middle-income countries. Preventive chemotherapy is the main strategy to control helminthiases. However, rapid re-infection occurs in settings where there is a lack of clean water, sanitation and hygiene. In August and September 2014, we conducted a cross-sectional epidemiological survey in 56 communities of three departments of south-central Côte d'Ivoire. Study participants were invited to provide stool and urine samples...
May 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29773468/determination-of-vitamin-b-12-in-equine-urine-by-liquid-chromatography-inductively-coupled-plasma-mass-spectrometry
#13
Ross Wenzel, Derek Major, Karly Hesp, Philip Doble
Regulating authorities in the racing industry have restricted the administration of potentially performance enhancing cobalt salts to horses. There are severe penalties for trainers presenting horses with elevated urine cobalt concentrations, and compliance is ensured via analysis of total urinary cobalt at thresholds of 100 μg/L. When cobalt is present as part of the cobalamin molecule it is not considered performance enhancing. This paper demonstrates that a horse can excrete a significant proportion of a commercially available vitamin B12 injection in urine without metabolic modification...
May 9, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29773193/boron-intake-osteocalcin-polymorphism-and-serum-level-in-postmenopausal-osteoporosis
#14
Olcay Boyacioglu, Seda Orenay-Boyacioglu, Hatice Yildirim, Mehmet Korkmaz
The relationship between daily boron intake and osteocalcin-mediated osteoporosis was studied in boron-exposed postmenopausal women. It is known that boron and osteocalcin are important in bone metabolism, however the effect of boron in bone metabolism has not been fully discovered. The study was performed on 53 postmenopausal women aged 55-60 living in parts of Balikesir, Turkey, where the subjects are naturally exposed to high (≥1 mg/L) or low (<1 mg/L) boron concentration in drinking water. 24-h urine samples were collected from all participants and creatinine clearance was detected...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29773185/kinetics-and-tissue-distribution-of-bismuth-tin-and-lead-after-implantation-of-miniature-shotgun-alloy-pellets-in-rats
#15
Vidar Skaug, Einar Eilertsen, Asbjørn Skogstad, Finn E S Levy, Balázs Berlinger, Yngvar Thomassen, Dag G Ellingsen
INTRODUCTION: Shotgun pellets containing bismuth (Bi) as substitute for lead (Pb) are increasingly being used due to environmental concerns. Information on toxicokinetics of Bi is lacking for the assessment of humans accidentally shot by Bi-containing shotgun alloy pellets. METHODS: Male Wistar rats were exposed to miniature alloy pellets containing Bi, tin (Sn) and minor amounts of Pb by implantation in muscle tissues of the hind legs. RESULTS: The concentrations of Bi in whole blood and urine increased up to 53 weeks after implantation...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29773169/comparison-of-the-effect-of-dietary-copper-nanoparticles-and-one-copper-ii-salt-on-the-metabolic-and-immune-status-in-a-rat-model
#16
Ewelina Cholewińska, Jerzy Juśkiewicz, Katarzyna Ognik
The aim of the study was to evaluate the effects of a diet containing different levels of Cu in two different chemical forms (carbonate and nanoparticles) on metabolic, immune and antioxidant status in a rat model. Five experimental treatments (8 rats in each) were used to test different dosages of Cu added to the diet (standard -6.5 mg/kg, half the standard dosage -3.25 mg/kg, and no added Cu as a negative control) and two sources of added copper (standard -CuCO3 and copper nanoparticles -CuNPs). Blood and urine samples were collected from all the animals after four weeks of treatment...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29772600/an-accurate-bacterial-dna-quantification-assay-for-hts-library-preparation-of-human-biological-samples
#17
Sarah Seashols-Williams, Raquel Green, Denise Wohlfahrt, Angela Brand, Antonio Limjuco Tan-Torres, Francy Nogales, J Paul Brooks, Baneshwar Singh
Sequencing and classification of microbial taxa within forensically relevant biological fluids has the potential for applications in the forensic science and biomedical fields. The quantity of bacterial DNA from human samples is currently estimated based on quantity of total DNA isolated. This method can miscalculate bacterial DNA quantity due to the mixed nature of the sample, and consequently library preparation is often unreliable. We developed an assay that can accurately and specifically quantify bacterial DNA within a mixed sample for reliable 16S ribosomal DNA (16S rDNA) library preparation and high throughput sequencing (HTS)...
May 17, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29770976/pharmacokinetic-and-pharmacodynamic-properties-of-orally-administered-torsemide-in-healthy-horses
#18
Gustavo F Agne, Seung Woo Jung, Anne A Wooldridge, Susan H Duran, William Ravis, Ramiro Toribio
BACKGROUND: Diuretic treatment is the mainstay for management of congestive heart failure in horses, and its use has been restricted to injectable medications because no currently data supports the use of PO administered loop diuretics. OBJECTIVES: To determine the pharmacokinetic and pharmacodynamic properties of PO administered torsemide and, determine if PO administered torsemide, could be used as an alternative to injectable diuretics in the horse. ANIMALS: Six healthy adult mares...
May 17, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29768398/urinary-metabolites-of-volatile-organic-compounds-of-infants-in-the-neonatal-intensive-care-unit
#19
Dina El-Metwally, Krista Chain, Matthew P Stefanak, Udeni Alwis, Benjamin C Blount, Judy S LaKind, Cynthia F Bearer
BackgroundPreterm infants (PTI) in the NICU are often placed in incubators that may increase their exposure to volatile organic chemicals (VOCs). To determine whether PTI in incubators have higher urinary concentrations of VOC metabolites compared with infants in cribs.MethodsUrine from 40 PTI in incubators and 40 infants in cribs was collected and analyzed for 28 urinary VOC biomarkers. Differences in metabolite concentrations between the two groups were compared.ResultsTwenty two of the VOC metabolites were detected in at least one urine sample...
May 16, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29767947/application-of-calcium-binding-motif-of-e-cadherin-for-electrochemical-detection-of-pb-ii
#20
Hamid R Lotfi Zadeh Zhad, Rebecca Y Lai
We report, for the first time, the use of a 13-amino-acid peptide sequence derived from the calcium-binding site of E-cadherin in the fabrication of an electrochemical peptide-based (E-PB) Pb(II) sensor. The sensing mechanism is analogous to that of previously developed E-PB sensors. Binding of Pb(II) rigidifies the surface-immobilized and methylene blue (MB)-modified peptide probe, thereby limiting the accessibility of the tethered MB to the electrode surface. This change in probe flexibility results in a reduction in the MB current that is dependent on the target concentration...
May 16, 2018: Analytical Chemistry
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