keyword
MENU ▼
Read by QxMD icon Read
search

PRL

keyword
https://www.readbyqxmd.com/read/28718206/delta-like-protein-1-in-the-pituitary-adipose-axis-in-the-adult-male-mouse
#1
Aixa R Bello, Ricardo A Puertas-Avendaño, María J González-Gómez, Miriam González-Gómez, Jorge Laborda, Carmen Damas, María Ruiz-Hidalgo, Carmen Diaz
With the aim of studying delta-like protein 1 (DLK1) implication in the relationship between adipocyte leptin and adenohypophyseal hormones, we carried out an immunohistochemical study to analyse the presence of receptors for these hormones in pituitary and adipose cells of male wildtype mice (Dlk1(+/+) ), compared to knockout mice (Dlk1(-/-) ). The mRNA expression of these molecules was also determined by RT-PCR. Our results showed that in wildtype adipose cells all the adenohypophyseal hormone receptors were present, with a higher mRNA expression for GHR and TSHR...
July 17, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28716399/prelimbic-%C3%AE-1-adrenoceptors-are-involved-in-the-regulation-of-depressive-like-behaviors-in-the-hemiparkinsonian-rats
#2
Zhong Heng Wu, Qiao Jun Zhang, Cheng Xue Du, Yue Xi, Wen Juan Li, Fang Yuan Guo, Shu Qi Yu, Ya Xin Yang, Jian Liu
At present, it is not clear whether α1-adrenoceptors in the prelimbic cortex (PrL) are involved in Parkinson's disease-related depression. Here we examined effects of PrL α1-adrenoceptors on depressive-like behaviors in rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. The lesion induced depressive-like responses as measured by the sucrose preference and forced swim tests compared to sham-operated rats. Intra-PrL injection of α1-adrenoceptor agonist phenylephrine induced or increased the expression of depressive-like behaviors in sham-operated and the lesioned rats...
July 14, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28710724/best-candidates-for-dopamine-agonist-withdrawal-in-patients-with-prolactinomas
#3
Myoung Jin Ji, Jung Hee Kim, Ji Hyun Lee, Jung Hyun Lee, Yong Hwy Kim, Sun Ha Paek, Chan Soo Shin, Seong Yeon Kim
PURPOSE: Dopamine agonist (DA) therapy is recommended as the first-line treatment for prolactinomas. However, it requires long treatment duration, and a high recurrence rate after DA withdrawal has been reported. We aimed to elucidate the predictors for long-term remission following DA withdrawal and propose the best candidates who can achieve complete remission after DA withdrawal. METHODS: In a retrospective cohort study, we included 89 patients with prolactinoma who have withdrawn DAs with normal prolactin (PRL) levels at Seoul National University Hospital, from 2000 to 2016...
July 14, 2017: Pituitary
https://www.readbyqxmd.com/read/28710500/men1-menin-regulates-milk-protein-synthesis-through-mtor-signaling-in-mammary-epithelial-cells
#4
Honghui Li, Xue Liu, Zhonghua Wang, Xueyan Lin, Zhengui Yan, Qiaoqiao Cao, Meng Zhao, Kerong Shi
The MEN1 gene, which encodes the protein Menin, was investigated for its regulatory role in milk protein synthesis in mammary glands. Menin responds to nutrient and hormone levels via the PI3K/Akt/mTOR pathway. Bovine mammary epithelial cells and tissues were used as experimental models in this study. The results revealed that the milk protein synthesis capacity of mammary epithelial cells could be regulated by MEN1/Menin. The overexpression of Menin caused significant suppression of factors involved in the mTOR pathway, as well as milk protein κ-casein (CSNK)...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710363/neural-correlates-of-altered-feedback-learning-in-women-recovered-from-anorexia-nervosa
#5
Franziska Ritschel, Daniel Geisler, Joseph A King, Fabio Bernardoni, Maria Seidel, Ilka Boehm, Richard Vettermann, Ronald Biemann, Veit Roessner, Michael N Smolka, Stefan Ehrlich
Anorexia nervosa (AN) is associated with exaggerated self-control and altered reward-based decision making, but the underlying neural mechanisms are poorly understood. Consistent with the notion of excessive cognitive control, we recently found increased dorsal anterior cingulate cortex (dACC) activation in acutely ill patients (acAN) on lose-shift trials in a probabilistic reversal learning (PRL) task. However, undernutrition may modulate brain function. In attempt to disentangle trait from state factors, the current fMRI study investigated cognitive control in recovered patients (recAN)...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710248/microrna-9-regulates-fetal-alcohol-induced-changes-in-d2-receptor-to-promote-prolactin-production
#6
Omkaram Gangisetty, Shaima Jabbar, Olivia Wynne, Dk K Sarkar
Fetal alcohol exposure (FAE) is known to increase prolactin (PRL) secretion from the pituitary lactotropes. In this study we determined whether microRNAs (miRs) are involved in FAE induced alteration in PRL release. We employed a rat animal model of FAE involving feeding pregnant Fisher 344 rats with a liquid diet containing 6.7% alcohol between gestational day 7 to 21 (AF). Both cyclic and estradiol implanted FAE females showed increased levels of plasma PRL and pituitary PRL mRNA but reduced levels of pituitary dopamine D2 receptor (D2R) and its short spliced form (D2S)...
July 14, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28700563/the-relationship-between-serum-levels-of-prolactin-and-growth-hormone-in-the-early-postnatal-period
#7
Jonathan Daliot, Tami Laron-Kenet, Mohammad Wattad, Anat Ben-Dor, Pearl Lilos, Zvi Laron
BACKGROUND: In the neonatal period, pituitary hormones including prolactin (PRL) and growth hormone (hGH) are secreted in high amounts due to immature feedback mechanisms. As both hormones are secreted in part by the same somatomammotrophic cells, we investigated their relationship in newborns in relation to sex, gestational week, method of delivery and anthropometric data. METHODS: Serum levels of PRL and hGH were measured in blood from 225 newborns. Newborn data were extracted from medical records...
July 12, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28698849/clinical-characteristics-treatment-and-outcome-of-primary-rectal-lymphoma-a-single-center-experience-of-16-patients
#8
Jae Ho Jeong, Shin Kim, Jeong Eun Kim, Dok Hyun Yoon, Sang-Wook Lee, Jooryung Huh, Cheolwon Suh
BACKGROUND: The rectum is a relatively uncommon site for lymphoma compared with other gastrointestinal sites; no consensus regarding management of primary rectal lymphoma (PRL) has been formed due to its limited frequency. We aimed to investigate clinical characteristics and treatment outcomes in patients with PRL in a single center patient cohort. METHODS: We retrospectively analyzed the results of 16 consecutive patients with PRL, identified and treated at the Asan Medical Center, Seoul, Korea between January 1993 and December 2014...
June 2017: Blood Research
https://www.readbyqxmd.com/read/28694859/interplay-between-prolactin-and-pathogenesis-of-psoriasis-vulgaris
#9
Delia Botezatu, Mihaela Tovaru, Simona-Roxana Georgescu, Oana-Diana Leahu, Calin Giurcaneanu, Antoanela Curici
INTRODUCTION: The polypeptide hormone prolactin (PRL) represents the pituitary modulator of lactation and reproduction. Currently, we discuss the wide range of PRL actions "beyond the mammary horizon". Multiple studies had showed the role of PRL as a cytokine, with comparable structural motifs, similar receptor structures and signal transduction pathways. Almost two decades ago it was fi rst hypothesized that PRL acts as a neuroendocrine modulator of both skin epithelial growth and the skin immune system...
September 2016: Mædica
https://www.readbyqxmd.com/read/28691248/adolescent-alcohol-exposure-decreases-frontostriatal-resting-state-functional-connectivity-in-adulthood
#10
Margaret A Broadwater, Sung-Ho Lee, Yang Yu, Hongtu Zhu, Fulton T Crews, Donita L Robinson, Yen-Yu Ian Shih
Connectivity of the prefrontal cortex (PFC) matures through adolescence, coinciding with emergence of adult executive function and top-down inhibitory control over behavior. Alcohol exposure during this critical period of brain maturation may affect development of PFC and frontolimbic connectivity. Adult rats exposed to adolescent intermittent ethanol (AIE; 5 g/kg ethanol, 25 percent v/v in water, intragastrically, 2-day-on, 2-day-off, postnatal day 25-54) or water control underwent resting-state functional MRI to test the hypothesis that AIE induces persistent changes in frontolimbic functional connectivity under baseline and acute alcohol conditions (2 g/kg ethanol or saline, intraperitoneally administered during scanning)...
July 9, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28690611/insight-into-the-endocrine-system-and-the-immune-system-a-review-of-the-inflammatory-role-of-prolactin-in-rheumatoid-arthritis-and-psoriatic-arthritis
#11
REVIEW
Man W Tang, Samuel Garcia, Danielle M Gerlag, Paul P Tak, Kris A Reedquist
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects females three times more frequently than males. A potential role for hormones, such as prolactin (PRL), may in part explain this phenomenon. The risk of developing RA is increased in women who are lactating after the first pregnancy, which might be related to breastfeeding and the release of PRL. Other studies found a protective effect of PRL on RA development. Some studies have reported that hyperprolactinemia is more common in RA and serum PRL levels are correlated with several disease parameters, although others could not confirm these findings...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28689770/vip-induces-the-decidualization-program-and-conditions-the-immunoregulation-of-the-implantation-process
#12
Esteban Grasso, Soledad Gori, Daniel Paparini, Elizabeth Soczewski, Laura Fernández, Lucila Gallino, Gabriela Salamone, Gustavo Martinez, Marcela Irigoyen, Claudio Ruhlmann, Claudia Pérez Leirós, Rosanna Ramhorst
The decidualization process involves phenotype and functional changes on endometrial cells and the modulation of mediators with immunoregulatory properties as the vasoactive intestinal peptide (VIP). We investigate VIP contribution to the decidualization program and to immunoregulation throughout the human embryo implantation process. The decidualization of Human endometrial stromal cell line (HESC) with Medroxyprogesterone-dibutyryl-cAMP increased VIP/VPAC-receptors system. In fact, VIP could induce decidualization increasing differentiation markers (IGFBP1, PRL, KLF13/KLF9 ratio, CXCL12, CXCL8 and CCL2) and allowing Blastocyst-like spheroids (BLS) invasion in an in vitro model of embryo implantation...
July 6, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28687229/the-phosphodiesterase-10a-selective-inhibitor-tak-063-induces-c-fos-expression-in-both-direct-and-indirect-pathway-medium-spiny-neurons-and-sub-regions-of-the-medial-prefrontal-cortex-in-rats
#13
Atsushi Nakatani, Sayuri Nakamura, Haruhide Kimura
TAK-063, a selective phosphodiesterase 10A (PDE10A) inhibitor, produces potent antipsychotic-like and pro-cognitive effects in rodents via balanced activation of striatal direct and indirect pathway medium spiny neurons (MSNs). Brain activity modulation by TAK-063 has been characterized using pharmacological magnetic resonance imaging and electroencephalography in animals, revealing modulation of activity in the prefrontal cortex (PFC) where there is little or no PDE10A expression. To understand the specific brain regions and cells affected by TAK-063 in rats, we assessed neural activation in the striatal complex and PFC using immunofluorescence staining to measure c-Fos expression...
July 4, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28685836/the-stability-of-the-transcriptome-during-the-estrous-cycle-in-four-regions-of-the-mouse-brain
#14
Lisa M DiCarlo, Cynthia Vied, Richard S Nowakowski
We analyzed the transcriptome of the C57BL/6J mouse hypothalamus, hippocampus, neocortex, and cerebellum to determine estrous cycle-specific changes in these four brain regions. We found almost 16,000 genes are present in one or more of the brain areas but only 210 genes, ∼1.3%, are significantly changed as a result of the estrous cycle. The hippocampus has the largest number of differentially expressed genes (DEGs) (82), followed by the neocortex (76), hypothalamus (63), and cerebellum (26). Most of these DEGs (186/210) are differentially expressed in only one of the four brain regions...
July 7, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28679293/sh3bgrl-as-a-novel-prognostic-biomarker-is-down-regulated-in-acute-myeloid-leukemia
#15
Limei Xu, Mingming Zhang, Hui Li, Wen Guan, Bin Liu, Fengqi Liu, Hehua Wang, Juan Li, Shulan Yang, Xiuzhen Tong, Haihe Wang
Phosphatase PRL-3 expression is positively associated to acute myeloid leukemia (AML) progression and drug resistance. SH3-domain-binding glutamic acid-rich protein-like protein (SH3BGRL), a downstream effector of PRL-3, plays a tumor suppressive role in solid tumors, but it remains elusive in AML. Here, we followed up and validated the relevance of SH3BGRL expression to AML progression in 116 cases. Results showed that SH3BGRL is down-regulated in 62.37% AML cases with poor prognosis. Cases with positive response to therapy accompanies with SH3GRL expression restoration...
July 6, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28674764/a-pilot-study-of-cabergoline-for-the-treatment-of-metastatic-breast-cancer
#16
Ricardo Costa, C A Santa-Maria, D M Scholtens, S Jain, L Flaum, W J Gradishar, C V Clevenger, V G Kaklamani
PURPOSE: The prolactin (PRL) receptor is over-expressed in breast cancer, and pre-clinical data indicate that it contributes to breast oncogenesis. Cabergoline is a potent dopamine receptor agonist of D2 receptors and has a direct inhibitory effect on pituitary PRL secretion. METHODS: A phase II study of cabergoline in patients with metastatic breast cancer was conducted. The primary end point of the study was to determine the clinical benefit rate (CBR) at 2 months...
July 3, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28673122/rejuvenating-effect-of-long-term-igf-i-gene-therapy-in-the-hypothalamus-of-aged-rats-with-dopaminergic-dysfunction
#17
Jose Ignacio Schwerdt, Micaela Lopez-Leon, Gloria Miriam Console, Oscar Alfedo Brown, Gustavo Ramon Morel, Eduardo Spinedi, Rodolfo Gustavo Goya
The aging female rat constitutes an interesting model of spontaneous and progressive age-related dopaminergic dysfunction as it allows assessing new therapeutic strategies for Parkinson's disease. Insulin-like growth factor I (IGF-I) is emerging as a powerful neuroprotective molecule which is strongly induced in the central nervous system after different insults. We constructed a helper-dependent recombinant adenoviral vector (HDRAd-IGFI) harboring the gene for rat IGF-I. This was used it to implement long-term IGF-I gene therapy in the hypothalamus of aged female rats, which display hypothalamic dopaminergic (DA) dysfunction and as a consequence, chronic hyperprolactinemia...
July 3, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28669683/effects-of-interferon-tau-on-endometrial-epithelial-cells-in-caprine-in-vitro
#18
Yue Zhang, Lei Zhang, Chao-Feng Yu, Xiao-Yan Du, Xiao-Rui Liu, Jun-Ze Liu, Xiao-Peng An, Jian-Gang Wang, Yu-Xuan Song, Guang Li, Bin-Yun Cao
Embryo attachment, a precondition of ruminant pregnancy, has been recognized to be related to apoptosis in endometrial epithelial cells (EECs). In ruminants, interferon tau (IFNT) is secreted by trophoblast of conceptus and works in a concentration-dependent style. To verify the function of IFNT in caprine embryo attachment, caprine EECs were dealt with IFNT at 0, 1, 10 and 100 ng/ml. In this study, IFNT arrested caprine EEC cell cycle in G2 phase and induced cell apoptosis at 1 ng/ml and 10 ng/ml of IFNT...
June 29, 2017: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/28660561/hormonal-effect-on-the-relationship-between-migraine-and-female-sexual-dysfunction
#19
Vasfiye Burcu Dogan, Hediye Dagdeviren, Ahmet Dirican, Ayten Ceyhan Dirican, Nurhan Kaya Tutar, Vidan Ayse Yayla, Hüseyin Cengiz
It is not a well-established finding in migraine that female sexual dysfunction (FSD) emerging as a natural course of disease, as a result of accompanying depression/anxiety, or an underlying endocrinological abnormality. Our aim is evaluating the relationship among frequency and severity of migraine, FSD, depression, anxiety, and related hormones in migrainous women. We examined 80 migrainous female and 62 controls cross sectionally. Beck Depression and Anxiety Inventories, Female Sexual Dysfunction Inventory, Migraine Disability Assessment Test, and hormonal analysis were done...
June 28, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28656242/microrna%C3%A2-21-promotes-neurite-outgrowth-by-regulating-pdcd4-in-a-rat-model-of-spinal-cord-injury
#20
Yuqing Jiang, Shujie Zhao, Yin Ding, Luming Nong, Haibo Li, Gongming Gao, Dong Zhou, Nanwei Xu
Altered expression levels of microRNA‑21 (miRNA‑21) have been observed in a series of pathological processes, including cancer and central nervous system injury; however, the involvement of miRNA‑21 in the molecular pathophysiology of spinal cord injury (SCI) has not been well documented. The present study examined the expression levels of miRNA‑21 and its predicted target genes, programmed cell death 4 (PDCD4) and phosphatase and tensin homolog (PTEN), in rats using quantitative polymerase chain reaction and western blotting to further understand the role of miRNA‑21 and the mechanisms underlying repair following SCI...
June 27, 2017: Molecular Medicine Reports
keyword
keyword
80759
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"