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https://www.readbyqxmd.com/read/29042974/curative-effect-of-laparoscopic-hysterectomy-for-uterine-fibroids-and-its-impact-on-ovarian-blood-supply
#1
Xing Wang, Li Lv, Zhiyong Cheng, Xuewu Zhou
This study evaluates the curative effects laparo-scopic hysterectomies performed to treat uterine fibroids and determined the impact of the procedures on ovarian blood supply. A total of 124 patients with uterine fibroids admitted and treated in our hospital from December 2014 to December 2015 participated in the study. Two groups of 62 patients each were formed according to different operating plans; one group of patients underwent abdominal (open) panhysterectomy and were set as the control group; with the other group of patients were treated with laparoscopic hysterectomy and were set as the observation group...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29040895/economic-analysis-of-prenatal-screening-strategies-for-down-syndrome-in-singleton-pregnancies-in-turkey
#2
Zeynep Güldem Ökem, Gökçen Örgül, Berna Tari Kasnakoglu, Mehmet Çakar, M Sinan Beksaç
OBJECTIVES: To examine the costs and outcomes of different screening strategies for Down Syndrome (DS) in singleton pregnancies. STUDY DESIGN: A decision-analytic model was developed to compare the costs and the outcomes of different prenatal screening strategies. Five strategies were compared for women under 35-year of age: 1A) triple test (TT), 2A); combined test (CT), 3A) Non-invasive Prenatal Screening Test by using cell free fetal DNA (NIPT), 4A) and 5A) NIPT as a second-step screening for high-risk patients detected by either TT, or CT respectively...
October 5, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29039523/analysis-of-men1-c-482g-a-p-gly161asp-mutation-in-a-pedigree-with-familial-multiple-endocrine-neoplasia-type-1
#3
Yuanyuan Luo, Yongxiang Sun, Xiaofan Zhu, Xialian Li
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the development of neuroendocrine tumors, which in turn are caused by mutations in the MEN1 gene. In the present study, a case of a 46‑year‑old woman who was clinically diagnosed with MEN1 based on the presence of prolactinoma and bilateral parathyroid adenoma was reported. The patient's serum prolactin (PRL) levels were successfully controlled via bromocriptine therapy, and the serum levels of calcium and intact parathyroid hormone (PTH) reduced one day following parathyroidectomy...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039247/high-throughput-in-silico-identification-and-characterization-of-plasmodium-falciparum-prl-phosphatase-inhibitors
#4
Rajan Pandey, Rakesh Kumar, Priya Gupta, Asif Mohmmed, Rita Tewari, Pawan Malhotra, Dinesh Gupta
Kinases and phosphatases are involved in many essential processes in Plasmodium life cycle. Among the identified 67 Plasmodium falciparum phosphatases, Phosphatase of Regenerating Liver (PRL) family protein homolog, PfPRL is an essential parasite tyrosine phosphatase. PfPRL is shown to be prenylated, secreted and involved in the host invasion process. In the present study, a structure based high throughput in-silico screening of PfPRL binders, using ChEMBL-NTD compounds lead to the identification of nine compounds based on binding energy, Lipinski rule of five and QED score...
October 17, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29033796/laminar-and-cellular-distribution-of-monoamine-receptors-in-rat-medial-prefrontal-cortex
#5
REVIEW
Noemí Santana, Francesc Artigas
The prefrontal cortex (PFC) is deeply involved in higher brain functions, many of which are altered in psychiatric conditions. The PFC exerts a top-down control of most cortical and subcortical areas through descending pathways and is densely innervated by axons emerging from the brainstem monoamine cell groups, namely, the dorsal and median raphe nuclei (DR and MnR, respectively), the ventral tegmental area and the locus coeruleus (LC). In turn, the activity of these cell groups is tightly controlled by afferent pathways arising from layer V PFC pyramidal neurons...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29031906/suckling-induced-insulin-like-growth-factor-1-igf-1-release-in-mother-rats
#6
András H Lékó, Melinda Cservenák, Árpád Dobolyi
OBJECTIVE: Lactation involves significant neuroendocrine changes. The elevated prolactin (PRL) release from the pituitary, induced markedly by suckling, is the most relevant example. Suckling also causes a significant and rapid elevation in growth hormone (GH) levels. GH is necessary for milk synthesis as milk yield is stopped completely in the absence of PRL and GH, while the absence of PRL alone causes only a 50% reduction. Insulin-like growth factor-1 (IGF-1) plays an important role in the GH axis...
October 10, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29030125/prolactin-gene-expression-in-the-pituitary-of-rats-subjected-to-vaginocervical-stimulation-requires-erk-1-2-signaling
#7
Patricia Reuquen, Emanuel Guajardo-Correa, María L Oróstica, Constanza Curotto, Alexis Parada-Bustamante, Hugo Cardenas, Pedro A Orihuela
Vaginocervical stimulation (VCS) induces twice-daily prolactin (PRL) surges resulting in pseudopregnancy in the rat. Furthermore, activation of the extracellular signal-regulated kinase-1/2 (Erk-1/2) is involved in the effect of estradiol (E2) on the Prl gene expression in pituitary cells. Herein, we investigated whether Erk-1/2 signaling is involved in the control of Prl expression in the pituitary of VCS rats and whether VCS regulates the effect of E2 on Erk-1/2 and Prl in the pituitary. Estrous rats were assigned as control or VCS groups and 0, 6, 12 or 24h later the levels and localization of phosphorylated Erk-1/2 (p-Erk-1/2) were analyzed in the pituitary...
October 10, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29028670/cord-blood-bisphenol-a-levels-and-reproductive-and-thyroid-hormone-levels-of-neonates-the-hokkaido-study-on-environment-and-children-s-health
#8
Machiko Minatoya, Seiko Sasaki, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Jun Yamamoto, Toru Matsumura, Takahiko Mitsui, Kimihiko Moriya, Kazutoshi Cho, Keita Morioka, Hisanori Minakami, Nobuo Shinohara, Reiko Kishi
BACKGROUND: Bisphenol A (BPA) is widely used and BPA exposure is nearly ubiquitous in developed countries. While animal studies have indicated adverse health effects of prenatal BPA exposure including reproductive dysfunction and thyroid function disruption possibly in a sex-specific manner, findings from epidemiologic studies have not been enough to prove these adverse effects. Given very limited research on human, the aim of this study was to investigate associations between cord blood BPA levels and reproductive and thyroid hormone levels of neonates and whether associations differed by neonate sex...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29025069/wnk-lysine-deficient-protein-kinase-1-regulates-human-endometrial-stromal-cell-decidualization-proliferation-and-migration-in-part-through-mitogen-activated-protein-kinase-7
#9
Nyssa R Adams, Yasmin M Vasquez, Qianxing Mo, William Gibbons, Ertug Kovanci, Francesco J DeMayo
The differentiation of endometrial stromal cells into decidual cells, termed decidualization, is an integral step in the establishment of pregnancy. The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor (EGFR) during decidualization. Primary human endometrial stromal cells (HESCs) were subjected to siRNA knockdown of WNK1 followed by in vitro decidualization. This abrogated expression of the decidual marker genes, IGFBP1 and PRL, and prevented adoption of decidual cell morphology...
August 30, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29018608/development-and-validation-of-near-infrared-spectroscopy-for-the-prediction-of-forage-quality-parameters-in-lolium-multiflorum
#10
Zhongfu Yang, Gang Nie, Ling Pan, Yan Zhang, Linkai Huang, Xiao Ma, Xinquan Zhang
Italian ryegrass (Lolium multiflorum) is an important cool-season, annual forage crop for the grassland rotation system in Southern China. The primary aim of breeding programs is always to seek to improve forage quality in the animal productivity system; however, it is time- and labor-consuming when analyzed excessive large number of samples. The main objectives of this study were to construct near-infrared reflectance spectroscopy (NIRS) models to predict the forage chemistry quality of Italian ryegrass including the concentrations of crude protein (CP), acid detergent fiber (ADF), neutral detergent fiber (NDF), and water soluble carbohydrate (WSC)...
2017: PeerJ
https://www.readbyqxmd.com/read/28988314/the-prostate-response-to-prolactin-modulation-in-adult-castrated-rats-subjected-to-testosterone-replacement
#11
Flávia B Constantino, Ana C L Camargo, Sérgio A A Santos, Ketlin T Colombelli, Laura F Martin, Marcia G Silva, Sérgio L Felisbino, Luis A Justulin
Despite the androgenic dependence, other hormones, growth factors, and cytokines are necessary to support prostatic growth and maintain the glandular structure; among them, prolactin is a non-steroidal hormone secreted mainly by the pituitary gland. However, extra-pituitary expression of prolactin, such as in the prostate, has also been demonstrated, highlighting the paracrine and autocrine actions of prolactin within the prostate. Here, we investigated whether prolactin modulation alters ventral prostate (VP) morphophysiology in adult castrated rats...
October 7, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28980126/expression-of-prl-3-regulates-proliferation-and-invasion-of-breast-cancer-cells-in-vitro
#12
Isabel Radke, Martin Götte, Martin Smollich, Ninette Scharle, Ludwig Kiesel, Pia Wülfing
PURPOSE: The protein tyrosine phosphatase PRL-3 plays an important role in cancer cell migration, invasion and metastasis. In breast cancer, PRL-3 is overexpressed in 70-75% of tumors and even more frequently in lymph node metastases. Moreover, PRL-3 overexpression in breast cancer is associated with an adverse disease outcome. Aim of this study was to determine the role of PRL-3 in breast cancer cell proliferation, migration and invasion in vitro. METHODS: PRL-3 mRNA expression was evaluated in 6 breast cancer cell lines by quantitative real-time PCR...
October 4, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28978177/binostril-endoscopic-transsphenoidal-neurosurgery-for-pituitary-adenomas-experience-with-42-patients
#13
Guan Sun, Ying Cao, Nan Jiang, Dekang Nie, Zhengqiang Wan, Min Li, Chiyuan Ma, Jun Guo
Here we review the technical aspects of our experience with the neuroendoscopic bilateral nostril (binostril) transsphenoidal approach for pituitary adenomas. A total of 42 patients were treated in our hospital from September 2013 to December 2015. Total tumor resection was completed in 31 cases, nearly full resection was achieved in 9 cases, and partial resection was achieved in 2 cases. In most cases clinical symptoms were relieved after surgery. These included 18/22 cases with visual field and vision disorders; 19/25 cases with headaches; 11/15 cases where high baseline PRL returned to normal levels; 6/7 cases where elevated blood GH returned to normal levels; and 2/3 cases where elevated blood ACTH returned to normal levels after surgery...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977606/subdomain-2-not-the-transmembrane-domain-determines-the-dimerization-partner-of-growth-hormone-receptor-and-prolactin-receptor
#14
Ying Liu, Jing Jiang, Bradford Lepik, Yue Zhang, Kurt R Zinn, Stuart J Frank
Growth hormone receptor (GHR) and prolactin (PRL) receptor (PRLR) are homologous transmembrane class I cytokine receptors. In humans, GH interacts with GHR homodimers or PRLR homodimers and PRL interacts with only PRLR homodimers to promote signaling. In human breast cancer cells endogenously expressing both receptors, GHR and PRLR specifically coimmunoprecipitate. We previously devised a split luciferase complementation assay to study GHR and PRLR assemblages. In this technique, firefly luciferase is split into two fragments (N- and C-terminal fragments of the luciferase), each without enzyme activity and tethered to the tails of two receptors...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28977591/novel-function-of-a-transcription-factor-wt1-in-regulating-decidualization-in-human-endometrial-stromal-cells-and-its-molecular-mechanism
#15
Isao Tamura, Yuichiro Shirafuta, Kousuke Jozaki, Takuya Kajimura, Masahiro Shinagawa, Ryo Maekawa, Toshiaki Taketani, Hiromi Asada, Shun Sato, Hiroshi Tamura, Norihiro Sugino
The Wilms tumor suppressor gene (WT1) encodes an essential transcription factor regulating mammalian urogenital development. However, the function of WT1 in human endometrium is still unclear. The current study examined the involvement of WT1 in the regulation of IGF-binding protein-1 (IGFBP-1) and prolactin (PRL), which are specific markers of decidualization, in human endometrial stromal cells (ESCs) undergoing decidualization. ESCs isolated from proliferative-phase endometrium were incubated with cyclic adenosine monophosphate (cAMP) to induce decidualization...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28974537/clc-2c-is-regulated-by-salinity-prolactin-and-extracellular-osmolality-in-tilapia-gill
#16
Jason Breves, Paige Keith, Bethany Hunt, Keano Pavlosky, Mayu Inokuchi, Yoko Yamaguchi, Darren Lerner, Andre P Seale, Gordon Grau
Teleosts inhabiting fresh water depend upon ion-absorptive ionocytes to counteract diffusive ion losses to the external environment. A Clc Cl- channel family member, Clc-2c, was identified as a conduit for basolateral Cl- transport by Na+/Cl- cotransporter 2 (Ncc2)-expressing ionocytes in stenohaline zebrafish (Danio rerio). It is unresolved whether Clc-2c/clc-2c is expressed in euryhaline species and how extrinsic and/or intrinsic factors modulate branchial clc-2c mRNA. Here, we investigated whether environmental salinity, prolactin (Prl) and osmotic conditions modulate clc-2c expression in euryhaline Mozambique tilapia (Oreochromis mossambicus)...
October 3, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28972407/the-role-of-the-ovarian-cycle-and-the-effects-of-mitogen-induced-cytokines-on-human-prolactin-gene-expression-in-peripheral-blood-mononuclear-cells
#17
Leticia González, Saúl Lira-Albarrán, Isabel Méndez, Lorenza Díaz, Fernando Larrea
BACKGROUND: little is known on the influences of normal menstrual cycle on prolactin gene expression in immune cells. AIM OF THE STUDY: to determine the effects of the ovarian cycle on prolactin and its receptor expression. METHODS: peripheral blood mononuclear cells (PBMC) were obtained from twenty-six normal menstruating women at different intervals of their menstrual cycle. The PBMC were incubated during 24 h in the presence or absence of Concanavalin-A (Con-A) and the gene expression of PRL, PRLR and cytokines was evaluated by qPCR...
October 3, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28971293/functional-changes-at-the-preferred-retinal-locus-in-subjects-with-bilateral-central-vision-loss
#18
Arun Kumar Krishnan, Harold E Bedell
PURPOSE: Subjects with bilateral central vision loss (CVL) use a retinal region called the preferred retinal locus (PRL) for performing various visual tasks. We probed the fixation PRL in individuals with bilateral macular disease, including age-related macular degeneration (AMD) and Stargardt disease (STGD), for localized sensitivity deficits. METHODS: Three letter words at the critical print size were presented in the NIDEK MP-1 microperimeter to determine the fixation PRL and its radial retinal eccentricity from the residual fovea in 29 subjects with bilateral CVL...
October 2, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28966800/parity-history-determines-a-systemic-inflammatory-response-to-spread-of-ovarian-cancer-in-naturally-aged-mice
#19
Ulises Urzua, Carlos Chacon, Luis Lizama, Sebastián Sarmiento, Pía Villalobos, Belén Kroxato, Katherine Marcelain, María-Julieta Gonzalez
Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and parity on the systemic inflammation markers that are particularly relevant to OC initiation and progression at menopause remain largely unknown. Herein, we profiled a panel of circulating cytokines in multiparous versus virgin C57BL/6 female mice at peri-estropausal age and investigated how cytokine levels were modulated by intraperitoneal tumor induction in a syngeneic immunocompetent OC mouse model...
October 2017: Aging and Disease
https://www.readbyqxmd.com/read/28966250/psychiatric-patients-with-antipsychotic-drug-induced-hyperprolactinemia-and-menstruation-disorders
#20
Kenshi Takechi, Yurika Yoshioka, Hitoshi Kawazoe, Mamoru Tanaka, Shingo Takatori, Miwako Kobayashi, Ichiro Matsuoka, Hiroaki Yanagawa, Yoshito Zamami, Masaki Imanishi, Keisuke Ishizawa, Akihiro Tanaka, Hiroaki Araki
Treatment with antipsychotic drugs has been associated with hyperprolactinemia. The same antipsychotic drugs have also been associated with side effects such as menstruation disorders. The aim of this study was to evaluate the prevalence of hyperprolactinemia and menstruation disorders in women undergoing antipsychotic treatment. We performed a retrospective chart review study of psychiatric patients who underwent laboratory testing for serum prolactin (PRL) level between March 2011 and March 2015 in Ehime University Hospital...
2017: Biological & Pharmaceutical Bulletin
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