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https://www.readbyqxmd.com/read/28099241/fmri-with-central-vision-loss-effects-of-fixation-locus-and-stimulus-type
#1
Tina Plank, Jozef Frolo, Sabine Brandl-Rühle, Agnes B Renner, Herbert Jägle, Mark W Greenlee
PURPOSE: In patients with central visual field scotomata, a large part of visual cortex is not adequately stimulated. Patients often use a new eccentric fixation area on intact peripheral retina ("preferred retinal locus"-PRL) that functions as a pseudo-fovea. We used functional magnetic resonance imaging (fMRI) to examine whether stimulating this pseudo-fovea leads to increased activation or altered activation patterns in visual cortex in comparison to stimulating a comparable peripheral area in the opposite hemifield (OppPRL)...
January 18, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28088409/genome-wide-association-analysis-and-pathways-enrichment-for-lactation-persistency-in-canadian-holstein-cattle
#2
D N Do, N Bissonnette, P Lacasse, F Miglior, M Sargolzaei, X Zhao, E M Ibeagha-Awemu
Lactation persistency (LP), defined as the rate of declining milk yield after milk peak, is an economically important trait for dairy cattle. Improving LP is considered a good alternative method for increasing overall milk production because it does not cause the negative energy balance and other health issues that cows experience during peak milk production. However, little is known about the biology of LP. A genome-wide association study (GWAS) and pathway enrichment were used to explore the genetic mechanisms underlying LP...
January 11, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28079402/sexual-dysfunction-in-premenopausal-women-could-be-related-to-hormonal-profile
#3
Fabiene Bernardes Castro Vale, Bruna Barbosa Coimbra, Gerson Pereira Lopes, Selmo Geber
Female sexual dysfunction (FSD) is a public health problem that affects women's quality of life. Although the relationship between some hormones and the FSD has been described, it is not well established for all hormones. Therefore, the aim of our study was to evaluate the association between hormonal dysfunction and sexual dysfunction in premenopausal women. We performed a cross-sectional study with 60 patients with regular menstrual cycles, with age ranging from 18 to 44 years, with previous diagnosis of FSD...
January 12, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28077805/spin-exciton-interaction-and-related-micro-photoluminescence-spectra-of-znse-mn-dms-nanoribbon
#4
Lipeng Hou, Weichang Zhou, Bingsuo Zou, Yu Zhang, Junbo Han, Xinxin Yang, Zhihong Gong, Jingbo Li, Sishen Xie, Lijie Shi
For their spintronic applications the magnetic and optical properties of diluted magnetic semiconductors (DMS) have been studied widely. However, the exact relationships between their magnetic interactions and optical emission behaviors in DMS are not well understood yet due to their complicated microstructural and compositional characters from different growth and preparation techniques. Manganese (Mn) doped ZnSe nanoribbons with high quality were obtained by using the chemical vapor deposition (CVD) method...
January 12, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28068414/antibody-array-revealed-prl-3-affects-protein-phosphorylation-and-cytokine-secretion
#5
Yongyong Yang, Shenyi Lian, Lin Meng, Like Qu, Chengchao Shou
Phosphatase of regenerating liver 3 (PRL-3) promotes cancer metastasis and progression via increasing cell motility and invasiveness, however the mechanism is still not fully understood. Previous reports showed that PRL-3 increases the phosphorylation of many important proteins and suspected that PRL-3-enhanced protein phosphorylation may be due to its regulation on cytokines. To investigate PRL-3's impact on protein phosphorylation and cytokine secretion, we performed antibody arrays against protein phosphorylation and cytokines separately...
2017: PloS One
https://www.readbyqxmd.com/read/28062207/cardiometabolic-biomarkers-are-predictors-of-readmission-and-death-in-patients-hospitalized-for-acute-dyspnea
#6
Nathalie Lund, Klas Gränsbo, Camilla Wernersson, Olle Melander
BACKGROUND: Acute dyspnea affects a large heterogeneous patient group with high mortality and readmission rates. PURPOSE: To investigate if cardiometabolic biomarkers and clinical characteristics predict readmission and death in patients hospitalized for acute dyspnea. METHODS: 65 dyspnea patients at a general internal medicine ward were followed for six months. The combined endpoint was readmission or death. MEASUREMENTS AND RESULTS: Cardiometabolic biomarkers at admission were related to the endpoint in Cox proportional hazard models (adjusted for sex, age, oxygen saturation, respiratory rate and C-reactive protein (CRP))...
December 22, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28051155/loss-of-mir-542-3p-enhances-igfbp-1-expression-in-decidualizing-human-endometrial-stromal-cells
#7
Hideno Tochigi, Takeshi Kajihara, Yosuke Mizuno, Yumi Mizuno, Shunsuke Tamaru, Yoshimasa Kamei, Yasushi Okazaki, Jan J Brosens, Osamu Ishihara
Endometrial decidualization represents an essential step for the successful implantation of the embryo; however, the molecular mechanism behind this differentiation process remains unclear. This study aimed to identify novel microRNAs (miRNAs) involved in the regulation of decidual gene expression in human endometrial stromal cells (HESCs). An in vitro analysis of primary undifferentiated and decidualizing HESCs was conducted. HESCs were isolated from hysterectomy specimens from normally cycling premenopausal women with uterine fibroids, who were not on hormonal treatment at the time of surgery...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28035005/histone-h1-and-chromosomal-protein-hmgn2-regulate-prolactin-induced-stat5-transcription-factor-recruitment-and-function-in-breast-cancer-cells
#8
Suzanne M Schauwecker, J Julie Kim, Jonathan D Licht, Charles V Clevenger
The hormone prolactin (PRL) contributes to breast cancer pathogenesis through various signaling pathways, one of the most notable being the JAK2/signal transducer and activator of transcription 5 (STAT5) pathway. PRL-induced activation of the transcription factor STAT5 results in the upregulation of numerous genes implicated in breast cancer pathogenesis. However, the molecular mechanisms that enable STAT5 to access the promoters of these genes are not well understood. Here, we show that PRL signaling induces chromatin decompaction at promoter DNA, corresponding with STAT5 binding...
December 29, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28028951/increased-expression-of-tlr4-and-tlr7-but-not-prolactin-mrna-by-peripheral-blood-monocytes-in-active-celiac-disease
#9
Iva Brynychova, Iva Hoffmanova, Milos Dvorak, Pavlina Dankova
BACKGROUND: Celiac disease (CD) is an organ-specific autoimmune disease, and both adaptive and innate immunity are involved in its development. OBJECTIVES: The aim of the study was to determine whether the markers of intestinal mucosal inflammation in CD can be detected in peripheral blood monocytes (PBMs), and whether the immune properties of PBMs change as the clinical signs and symptoms of CD improve after the introduction of a gluten-free diet (GFD). The focus was on changes in mRNA expression of selected toll-like receptors (TLR2, TLR4, TLR7), stress cytokine prolactin (PRL), and proand anti-inflammatory cytokines (TNF-α, IL-6, IL-12, IL-10) in PBMs...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028299/gene-expression-in-obstetric-antiphospholipid-syndrome-a-systematic-review
#10
M Muhammad Aliff, S Muhammad Shazwan, M M Nur Fariha, A R Hayati, A R Nur Syahrina, M Maizatul Azma, A H Nazefah, S Jameela, A A Asral Wirda
BACKGROUND: Antiphospholipid syndrome (APS) is a multisystem disease that may present as venous or arterial thrombosis and/or pregnancy complications with the presence of antiphospholipid antibodies. Until today, heterogeneity of pathogenic mechanism fits well with various clinical manifestations. Moreover, previous studies have indicated that genes are differentially expressed between normal and in the disease state. Hence, this study systematically searched the literature on human gene expression that was differentially expressed in Obstetric APS...
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28027382/training-eye-movements-for-visual-search-in-individuals-with-macular-degeneration
#11
Christian P Janssen, Preeti Verghese
We report a method to train individuals with central field loss due to macular degeneration to improve the efficiency of visual search. Our method requires participants to make a same/different judgment on two simple silhouettes. One silhouette is presented in an area that falls within the binocular scotoma while they are fixating the center of the screen with their preferred retinal locus (PRL); the other silhouette is presented diametrically opposite within the intact visual field. Over the course of 480 trials (approximately 6 hr), we gradually reduced the amount of time that participants have to make a saccade and judge the similarity of stimuli...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/28025846/prolactin-and-growth-hormone-immunoactivity-in-canine-mammary-adenomas-and-adenocarcinomas
#12
E R Bohrer, C V Löhr, M A Kutzler
It is now widely accepted in human medicine that prolactin (PRL) and growth hormone (GH) function in the mammary gland in an autocrine and paracrine manner in tumour formation. The aim of this study was to compare PRL and GH immunoactivity in canine mammary tumours submitted for histopathologic evaluation. Formalin-fixed specimens from spontaneously occurring mammary adenomas and adenocarcinomas from 24 female client-owned dogs were used. Information pertaining to the reproductive status of the patient at the time of mammary tumour diagnosis was obtained from each of the submitting veterinarians...
December 27, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28017595/brain-prolactin-is-involved-in-stress-induced-rem-sleep-rebound
#13
Ricardo Borges Machado, Murilo Ramos Rocha, Deborah Suchecki
REM sleep rebound is a common behavioural response to some stressors and represents an adaptive coping strategy. Animals submitted to multiple, intermittent, footshock stress (FS) sessions during 96h of REM sleep deprivation (REMSD) display increased REM sleep rebound (when compared to the only REMSD ones, without FS), which is correlated to high plasma prolactin levels. To investigate whether brain prolactin plays a role in stress-induced REM sleep rebound two experiments were carried out. In experiment 1, rats were either not sleep-deprived (NSD) or submitted to 96h of REMSD associated or not to FS and brains were evaluated for PRL immunoreactivity (PRL-ir) and determination of PRL concentrations in the lateral hypothalamus and dorsal raphe nucleus...
December 23, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/28012629/relationship-between-glucocorticoids-and-prolactin-during-mammary-gland-stimulation-in-dairy-cows
#14
B Ponchon, X Zhao, S Ollier, P Lacasse
The objectives of this study were to determine the role of glucocorticoids in the regulation of prolactin (PRL) release induced by mammary gland stimulation and to investigate whether the milk depression induced by glucocorticoids in dairy cows is due to a decrease in PRL release. In experiment 1, 8 dairy cows were used in a 4 × 4 Latin square design. Four hours after the morning milking, the cows received 1 of the following treatments: (1) a 5-min manual stimulation of the mammary gland; (2) an i.v. injection of 1 mg of dexamethasone; (3) 2 infusions of 2...
December 21, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/28011885/lin28b-activation-by-prl-3-promotes-leukemogenesis-and-a-stem-cell-like-transcriptional-program-in-aml
#15
Jianbiao Zhou, Zit-Liang Chan, Chonglei Bi, Xiao Lu, Phyllis Sy Chong, Jing-Yuan Chooi, Lip Lee Cheong, Shaw-Cheng Liu, Ying Qing Ching, Yafeng Zhou, Motomi Osato, Tuan Zea Tan, Chin Hin Ng, Siok-Bian Ng, Qi Zeng, Wee Joo Chng
: PRL-3 (PTP4A3), a metastasis-associated phosphatase, is also upregulated in patients with acute myeloid leukemia (AML) and is associated with poor prognosis, but the underlying molecular mechanism is unknown. Here, constitutive expression of PRL-3 in human AML cells sustains leukemogenesis in vitro and in vivo. Furthermore, PRL-3 phosphatase-activity dependently upregulates LIN28B, a stem cell reprogramming factor, which, in turn, represses the let-7 microRNA family, inducing a stem cell-like transcriptional program...
December 23, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28007522/the-pupillary-light-reflex-for-predicting-the-risk-of-hypotension-after-spinal-anaesthesia-for-elective-caesarean-section
#16
Céline Riffard, Truong Quoc Viêt, François-Pierrick Desgranges, Lionel Bouvet, Bernard Allaouchiche, Adrienne Stewart, Dominique Chassard
INTRODUCTION: The balance between the sympathetic and parasympathetic systems could be used to predict the onset of hypotension following spinal anaesthesia. The autonomic innervation of the pupil may reflect this balance. The aim of this study was to evaluate the ability of pupillometry to predict the risk of hypotension after spinal anaesthesia for caesarean section. METHODS: Two hundred patients receiving spinal anaesthesia for caesarean section were recruited...
December 19, 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28003411/dorsal-versus-ventral-differences-in-fast-up-state-associated-oscillations-in-the-medial-prefrontal-cortex-mpfc-of-the-urethane-anaesthetised-rat
#17
Sabine Gretenkord, Adrian Rees, Miles A Whittington, Sarah E Gartside, Fiona E N LeBeau
Cortical slow oscillations (0.1 - 1 Hz), which may play a role in memory consolidation, are a hallmark of non-rapid eye movement (NREM) sleep and also occur under anaesthesia. During slow oscillations the neuronal network generates faster oscillations on the active Up-states and these nested oscillations are particularly prominent in the PFC. In rodents the mPFC consists of several subregions: anterior cingulate cortex (ACC), prelimbic (PrL), infralimbic (IL) and dorsal peduncular cortices (DP). Although each region has a distinct anatomy and function, it is not known whether slow or fast network oscillations differ between subregions in vivo...
December 21, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27999593/long-term-clinical-outcomes-of-invasive-giant-prolactinomas-after-a-mean-ten-year-followup
#18
Ze Rui Wu, Yong Zhang, Lin Cai, Shao Jian Lin, Zhi Peng Su, Yong Xu Wei, Han Bing Shang, Wen Lei Yang, Wei Guo Zhao, Zhe Bao Wu
Objective. The aim of this study is to observe clinical outcomes after more than ten years of followup in a group of patients with invasive giant prolactinomas (IGPs) treated with dopamine agonists (DAs). Methods. Twenty-five patients met the criteria of IGPs, among which 16 patients primarily received bromocriptine (BRC) and the other nine had undergone unsuccessful microsurgery prior to BRC treatment. Results. After a mean follow-up period of 135.5 ± 4.7 months, the clinical symptoms in all patients improved by different degrees...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27999489/neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-in-patients-with-nsclc
#19
Vesna Cukic
OBJECTIVE: to compare neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with NSCLC (Non- Small- Cell Lung Cancer): with and without metastases at the time of diagnosis to find out if there is the importance of these cell ratios in the assessment of severity NSCLC. MATERIAL AND METHODS: this is the retrospective analysis of NRL and PRL in patients with NSCLC at the time of the diagnosis of disease before any anti tumor treatment (chemotherapy, radiotherapy, surgery)...
October 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/27995323/mucosa-associated-lymphoid-tissue-malt-variant-of-primary-rectal-lymphoma-a-review-of-the-english-literature
#20
REVIEW
Scott R Kelley
PURPOSE: Primary rectal lymphoma (PRL) is the third most common cause of rectal cancer following adenocarcinoma (90-95 %) and carcinoid (5 %). The most common variant of PRL is the mucosa-associated lymphoid tissue (MALT) type. To date, no study has been able to recommend an optimal treatment algorithm for this rare disease. The aim of our study was to review the English literature on primary rectal MALT lymphoma. METHODS: A review of the English literature was conducted to identify articles describing the MALT variant of PRL...
December 19, 2016: International Journal of Colorectal Disease
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