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https://www.readbyqxmd.com/read/28109033/a-quality-improvement-initiative-to-decrease-the-rate-of-solitary-blood-cultures-in-the-emergency-department
#1
Joseph Choi, Sahand Ensafi, Lucas Brien Chartier, Oliver Van Praet
OBJECTIVES: Best practice guidelines recommend that at least two sets of blood cultures (BCs) be sent when blood cultures are required. However, high rates of solitary BCs are still common in the emergency department (ED). The aim of this study was to evaluate the efficacy of different quality improvement initiatives aimed at reducing the rate of solitary blood cultures being sent to the lab on patients ultimately discharged from our ED. METHODS: This was a multi-centre, multi-phase, prospective study evaluating a comprehensive education-based intervention and a second intervention that combined a computerized forcing function along with a brief education-based intervention...
January 20, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28107895/psychological-distress-longitudinally-mediates-the-effect-of-vertigo-symptoms-on-vertigo-related-handicap
#2
Thomas Probst, Andreas Dinkel, Gabriele Schmid-Mühlbauer, Katharina Radziej, Karina Limburg, Christoph Pieh, Claas Lahmann
OBJECTIVE: Vertigo symptoms can lead to more or less vertigo-related handicap. This longitudinal study investigated whether depression, anxiety, and/or somatization mediate the relationship between vertigo symptoms and vertigo-related handicap. METHODS: N=111 patients with vertigo/dizziness provided complete data on the following measures: Vertigo symptoms at baseline, depression at 6-month follow-up, anxiety at 6-month follow-up, somatization at 6-month follow-up, and vertigo handicap at 12-month follow-up...
February 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28107458/neuropilin-1-involvement-in-choroidal-and-retinal-neovascularisation
#3
Patricia Fernández-Robredo, Senthil Selvam, Michael B Powner, Dawn A Sim, Marcus Fruttiger
PURPOSE: Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO). Neuropilin 1 (Nrp1) is a co-receptor for VEGF and many other growth factors, and therefore a possible alternative drug target in intra ocular neovascular disease. Here we assessed choroidal and retinal NV in an inducible, endothelial specific knock out model for Nrp1...
2017: PloS One
https://www.readbyqxmd.com/read/28107310/the-renin-inhibitor-aliskiren-protects-rat-lungs-from-the-histopathologic-effects-of-fat-embolism
#4
Amanda N Fletcher, Agostino Molteni, Rakesh Ponnapureddy, Chirag Patel, Mark Pluym, Alan M Poisner
BACKGROUND: Fat embolism (FE) and the consequent FE syndrome occurring after trauma or surgery can lead to serious pulmonary injury, including ARDS and death. Current treatment of FE syndrome is limited to supportive therapy. We have shown in a rat model that the renin angiotensin system plays a significant role in the pathophysiology of FE because drugs interfering with the renin angiotensin system, captopril and losartan reduce the histopathologic pulmonary damage. The purpose of the current study was to determine if inhibition of renin by aliskiren, an FDA-approved drug for treating hypertension, would produce effective protection in the same model...
February 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28106560/face-name-associative-recognition-deficits-in-subjective-cognitive-decline-and-mild-cognitive-impairment
#5
Alexandra Polcher, Ingo Frommann, Alexander Koppara, Steffen Wolfsgruber, Frank Jessen, Michael Wagner
BACKGROUND: There is a need for more sensitive neuropsychological tests to detect subtle cognitive deficits emerging in the preclinical stage of Alzheimer's disease (AD). Associative memory is a cognitive function supported by the hippocampus and affected early in the process of AD. OBJECTIVE: We developed a short computerized face-name-associative-recognition test (FNART) and tested whether it would detect memory impairment in memory-clinic patients with mild cognitive impairment (MCI) and subjective cognitive decline (SCD)...
January 19, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28105957/identification-of-nuclear-genes-controlling-chlorophyll-synthesis-in%C3%A2-barley-by-rna-seq
#6
Nickolay A Shmakov, Gennadiy V Vasiliev, Natalya V Shatskaya, Alexey V Doroshkov, Elena I Gordeeva, Dmitry A Afonnikov, Elena K Khlestkina
BACKGROUND: Albinism in plants is characterized by lack of chlorophyll and results in photosynthesis impairment, abnormal plant development and premature death. These abnormalities are frequently encountered in interspecific crosses and tissue culture experiments. Analysis of albino mutant phenotypes with full or partial chlorophyll deficiency can shed light on genetic determinants and molecular mechanisms of albinism. Here we report analysis of RNA-seq transcription profiling of barley (Hordeum vulgare L...
November 16, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/28102955/compound-speckle-model-detects-anti-angiogenic-tumor-response-in-preclinical-nonlinear-contrast-enhanced-ultrasonography
#7
Matthew R Lowerison, Justin J Tse, M Nicole Hague, Ann F Chambers, David W Holdsworth, James C Lacefield
PURPOSE: This paper proposes a method for analyzing the first-order speckle statistics of nonlinear contrast-enhanced ultrasound images from tumors. METHODS: Contrast signal intensity is modeled as a compound distribution of exponential probability density functions with a gamma weighting function. The gamma probability weighting function serves as an approximation for log-normally distributed flow velocities in a vascular network. The model was applied to sub-harmonic bolus-injection images acquired from a mouse breast cancer xenograft model treated with murine version bevacizumab...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102940/effect-of-cast-modification-on-denture-base-adaptation-following-maxillary-complete-denture-processing
#8
Mohammed E Sayed, Amit Porwal, David Ehrenberg, Saul Weiner
PURPOSE: To investigate the effect of cast modifications on denture base adaptation in coronal and sagittal projections following maxillary complete denture processing. MATERIALS AND METHODS: A total of 60 edentulous maxillary casts (n = 10) were distributed among six groups. Group 1 was the control group with no modification, groups 2 through 6 included a butterfly postdam preparation, groups 3 and 4 also included a 10-mm wide/4-mm deep box with addition of four round holes in group 4, and groups 5 and 6 also included a 20-mm wide/4-mm deep box with addition of four round holes in group 6...
January 19, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28102326/demonstration-of-the-protein-involvement-in-cell-electropermeabilization-using-confocal-raman-microspectroscopy
#9
Antoine Azan, Valérie Untereiner, Cyril Gobinet, Ganesh D Sockalingum, Marie Breton, Olivier Piot, Lluis M Mir
Confocal Raman microspectroscopy was used to study the interaction between pulsed electric fields and live cells from a molecular point of view in a non-invasive and label-free manner. Raman signatures of live human adipose-derived mesenchymal stem cells exposed or not to pulsed electric fields (8 pulses, 1 000 V/cm, 100 μs, 1 Hz) were acquired at two cellular locations (nucleus and cytoplasm) and two spectral bands (600-1 800 cm(-1) and 2 800-3 100 cm(-1)). Vibrational modes of proteins (phenylalanine and amide I) and lipids were found to be modified by the electropermeabilization process with a statistically significant difference...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101340/pseudo-continuous-arterial-spin-labeling-imaging-of-cerebral-blood-perfusion-asymmetry-in-drug-na%C3%A3-ve-patients-with-first-episode-major-depression
#10
Guangdong Chen, Haiman Bian, Deguo Jiang, Mingwei Cui, Shengzhang Ji, Mei Liu, Xu Lang, Chuanjun Zhuo
Many previous studies have reported that regional cerebral blood flow (rCBF) aberrations may be one of the pathological characteristics of depression and rCBF has demonstrated a certain degree of asymmetry. However, studies investigating the cerebral blood perfusion asymmetry changes of drug-naïve patients experiencing their first episode of major depression using pseudo-continuous arterial spin labeling (pCASL) are rare. Ten drug-naïve patients experiencing their first major depression episode and 15 healthy volunteers were enrolled in the current study...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28099018/reactive-ni-al-nanocomposites-structural-characteristics-and-activation-energy
#11
Christopher E Shuck, Alexander S Mukasyan
Stochastically structured Ni/Al reactive nanocomposites (RNCs) were prepared using short term high-energy ball milling. Differing milling times were utilized to prepared RNCs with differing internal nanostructures. These internal structures were quantitatively and statistically analyzed by use of serial focused ion beam sectioning coupled with 3D reconstruction techniques. The reaction kinetics were analyzed using the electrothermal explosion technique for each milling condition. It is shown that the effective activation energy (Eef) ranges from 79-137 kJ/mol and is directly related to the surface area contact between the reactants...
January 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28098954/use-of-play-therapy-in-nursing-process-a-prospective-randomized-controlled-study
#12
Emel Sezici, Ayse Ferda Ocakci, Hasibe Kadioglu
PURPOSE: Play therapy is a nursing intervention employed in multidisciplinary approaches to develop the social, emotional, and behavioral skills of children. In this study, we aim to determine the effects of play therapy on the social, emotional, and behavioral skills of pre-school children through the nursing process. DESIGN: A single-blind, prospective, randomized controlled study was undertaken. The design, conduct, and reporting of this study adhere to the Consolidated Standards of Reporting Trials (CONSORT) guidelines...
January 18, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28098288/ag-au-bimetallic-nanoclusters-formed-from-a-homogeneous-gas-phase-a-new-thermodynamic-expression-confirmed-by-molecular-dynamics-simulation
#13
H Akbarzadeh, A N Shamkhali, E Mehrjouei
In this work, two probabilistic and thermodynamic limits for formation of a bimetallic nanocluster from a homogeneous gas phase were obtained in order to investigate the related phenomena using molecular dynamics simulation. Therefore, by application of some simple assumptions from thermodynamics and statistical mechanics, a new expression for composition of the nanocluster was derived which depends only on the initial conditions of the system and one adjustable parameter. This expression can be easily fitted to the results of molecular dynamics and can be used as a measure of the thermodynamic contribution in the cluster formation process...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28097835/cognitive-profiles-of-patients-with-early-detected-and-treated-congenital-hypothyroidism
#14
María L Pardo Campos, Mariel Musso, Ana Keselman, Laura Gruñeiro, Ignacio Bergadá, Ana Chiesa
INTRODUCTION: Children with congenital hypothyroidism (CH) detected by newborn screening and adequately treated may have mild cognitive deficits. OBJECTIVES">To assess the intelligence quotient of children with CH and identify the presence of specific cognitive deficits. POPULATION AND METHODS: A group of 60 children with CH detected by newborn screening, who were aged 9-10 years old and received adequate treatment since their first month of life was selected and compared to a control group of 60 children without CH in the same age range...
1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28097179/the-comparison-of-two-types-of-relaxation-techniques-on-postoperative-state-anxiety-in-candidates-for-the-mastectomy-surgery-a-randomized-controlled-clinical-trial
#15
Zohreh Parsa Yekta, Fatemeh Sadeghian, Taraneh Taghavi Larijani, Abbas Mehran
BACKGROUND: Anxiety among patients after surgery can affect their physiological and psychological well-being. The aim of this study was to investigate and compare the effects of Benson's relaxation and rhythmic breathing techniques on postoperative anxiety in candidates for the mastectomy surgery. METHODS: This randomized controlled clinical trial study was conducted with ninety patients in 2013. The patients were hospitalized for the mastectomy surgery in three surgical wards in a teaching hospital, Tehran, Iran...
January 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/28097161/effects-of-extremely-low-frequency-electromagnetic-field-on-expression-levels-of-some-antioxidant-genes-in-human-mcf-7-cells
#16
Hamideh Mahmoudinasab, Fatemeh Sanie-Jahromi, Mostafa Saadat
In the past three decades, study on the biological effects of extremely low-frequency electromagnetic fields (ELF-EMFs) has been of interest to scientists. Although the exact mechanism of its effect is not fully understood, free radical processes has been proposed as a possible mechanism. This study was designed to evaluate the effect of 50-Hz EMFs on the mRNA levels of seven antioxidant genes (CAT, SOD1, SOD2, GSTO1, GSTM3, MSGT1, and MSGT3) in human MCF-7 cells. The EMF exposure patterns were: 1) 5 min field-on/5 min filed-off, 2) 15 min field-on/15 min field-off, 3) 30 min field-on continuously...
June 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28093277/evaluating-the-relationship-between-sublexical-and-lexical-processing-in-speech-perception-evidence-from-aphasia
#17
Heather Dial, Randi Martin
Several studies have reported that aphasic patients may perform substantially better on lexical than sublexical perception tasks (e.g., Miceli, Gainotti, Caltagirone, & Masullo, 1980). These findings challenge claims made by models of speech perception which assume obligatory sublexical processing (e.g., McClelland & Elman, 1986; Norris, 1994). However, prior studies have not closely matched the phonological similarity of targets and distractors or task demands of the sublexical and lexical perception tasks...
January 13, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28090465/does-intrauterine-injection-of-low-molecular-weight-heparin-improve-the-clinical-pregnancy-rate-in-intracytoplasmic-sperm-injection
#18
Ahmed Mohamed Kamel, Yahia El-Faissal, Mona Aboulghar, Ragaa Mansour, Gamal I Serour, Mohamed Aboulghar
OBJECTIVE: Heparin can modulate proteins, and influence processes involved in implantation and trophoblastic development. This study aimed to assess the improvement of clinical pregnancy and implantation rates after local intrauterine injection of low-molecular-weight heparin (LMWH) in patients undergoing intracytoplasmic sperm injection (ICSI). METHODS: A randomised case/control design was followed in women scheduled for ICSI. The study arm was injected with intrauterine LMWH during mock embryo transfer immediately following the ovum pickup procedure, while the control arm was given an intrauterine injection with a similar volume of tissue culture media...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28089115/correlation-of-antimuscarinic-acetylcholine-receptor-antibody-titers-and-antidesmoglein-antibody-titers-with-the-severity-of-disease-in-patients-with-pemphigus
#19
Manimegalai Jeyasekaran Dhanabhakya Lakshmi, Telanseri Jaykar Jaisankar, Medha Rajappa, Devinder Mohan Thappa, Laxmisha Chandrashekar, Dakshinamurthy Divyapriya, Malathi Munisamy, Gunaseelan Revathy
BACKGROUND: Acetylcholine receptor (AchR) antibody levels significantly correlate with disease severity at initial pemphigus diagnosis and during follow-up. However, it is not clear if they are just an epiphenomenon or a potential trigger of the known pathogenic process in pemphigus vulgaris. OBJECTIVE: We sought to assess the changes in anti-muscarinic (M3) AchR and anti-desmoglein (Dsg) antibody titers with therapy. METHODS: This was a hospital-based cohort study involving 45 patients with active pemphigus...
January 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28086921/a-randomized-controlled-trial-focusing-on-socio-economic-status-for-promoting-vegetable-intake-among-adults-using-a-web-based-nutrition-intervention-programme-study-protocol
#20
Saki Nakamura, Takayo Inayama, Takashi Arao
BACKGROUND: Web-based nutritional education programmes appear to be comparable to those delivered face-to-face. However, no existing web-based nutrition education or similar programme has yet been evaluated with consideration of socio-economic status. The objective of a nutritional education programme of promoting vegetable intake designed a randomized controlled trial (RCT) is to evaluate the results of intervention and to determine how socio-economic status influences the programme effects...
January 13, 2017: BMC Public Health
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