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https://www.readbyqxmd.com/read/29331682/post-mortem-tryptase-cut-off-level-for-anaphylactic-death
#1
R Tse, C X Wong, K Kesha, J Garland, Y Tran, S Anne, H Elstub, A D Cala, C Palmiere, K L Patchett
Serum mast cell tryptase is used to support the diagnosis of anaphylaxis. The recommended clinical cut-off for total tryptase (<11.4μg/L) appears unsuitable in the post mortem setting due to largely unknown processes which result in significantly elevated levels in these samples. Consequently there is no widely accepted tryptase cut-off level for diagnosing an anaphylactic death. This 5-year retrospective study compared total tryptase levels in post mortem femoral blood in anaphylactic deaths and control...
December 28, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29331599/long-term-reduction-of-seclusion-and-forced-medication-on-a-hospital-wide-level-implementation-of-an-open-door-policy-over-6-years
#2
L Hochstrasser, D Fröhlich, A R Schneeberger, S Borgwardt, U E Lang, R-D Stieglitz, C G Huber
BACKGROUND: Psychiatric inpatient treatment is increasingly performed in settings with locked doors. However, locked wards have well-known disadvantages and are ethically problematic. In addition, recent data challenges the hypothesis that locked wards provide improved safety over open-door settings regarding suicide, absconding and aggression. Furthermore, there is evidence that the introduction of an open-door policy may lead to short-term reductions in involuntary measures. The aim of this study was to assess if the introduction of an open-door policy is associated with a long-term reduction of the frequency of seclusion and forced medication...
December 11, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29329692/potential-psychological-neural-mechanisms-in-binge-eating-disorder-implications-for-treatment
#3
REVIEW
Hedy Kober, Rebecca G Boswell
Binge Eating Disorder (BED) is a newly-established eating disorder diagnosis in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Although systematic research on BED is in its infancy and many studies feature small samples, several observations emerge. First, we review diagnostic, developmental, and socio-demographic features of BED. Next, although BED and obesity are linked and frequently co-occur, we review data suggesting that BED is a distinct phenotype. Importantly, we take a mechanism-focused approach and propose four psychological processes with neurobiological bases that may uniquely differentiate BED from obesity: emotion reactivity, food-cue reactivity, food craving, and cognitive control...
December 23, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29325029/neuroconductor-an-r-platform-for-medical-imaging-analysis
#4
John Muschelli, Adrian Gherman, Jean-Philippe Fortin, Brian Avants, Brandon Whitcher, Jonathan D Clayden, Brian S Caffo, Ciprian M Crainiceanu
Neuroconductor (https://neuroconductor.org) is an open-source platform for rapid testing and dissemination of reproducible computational imaging software. The goals of the project are to: (i) provide a centralized repository of R software dedicated to image analysis, (ii) disseminate software updates quickly, (iii) train a large, diverse community of scientists using detailed tutorials and short courses, (iv) increase software quality via automatic and manual quality controls, and (v) promote reproducibility of image data analysis...
January 6, 2018: Biostatistics
https://www.readbyqxmd.com/read/29324924/mobile-phone-use-for-5-minutes-can-cause-significant-memory-impairment-in-humans
#5
F Kalafatakis, D Bekiaridis-Moschou, Eirini Gkioka, Magda Tsolaki
INTRODUCTION: Concerns about the possible adverse health effects of mobile phones (MP) have increased along with the expansion of their use. A number of research papers have tried to address this issue. Although many investigations concluded that MP use does have negative consequences, in terms of cognitive function of the human brain, the results so far have been divisive. A number of studies reported impairment of cognitive function after exposure to mobile phone electromagnetic field (MP EMF), while others observed no effect or improved performance...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324389/dynamic-validation-of-online-applied-and-surrogate-based-models-for-tertiary-ozonation-on-pilot-scale
#6
Michael Chys, Wim T M Audenaert, Jan Vangrinsven, Michael Bauwens, Séverine T F C Mortier, Herman Van Langenhove, Ingmar Nopens, Kristof Demeestere, Stijn W H Van Hulle
New robust correlation models for ozonation, based on UVA254 and fluorescence surrogate parameters and developed considering kinetic information, have been applied at pilot-scale. This model framework is validated with the aim for operators to control the ozone dose for the removal of trace organic contaminants (TrOCs) in effluents from full-scale municipal wastewater treatment plants. The inflected correlation model between ΔTrOCs and the surrogates predicts the removal of TrOCs (based on statistical evidence) solely using the 2nd order reaction rate constant with ozone (kO3) and in a more adequate manner than similar single correlation models...
December 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29322542/a-nonparametric-method-to-detect-increased-frequencies-of-adverse-drug-reactions-over-time
#7
Günter Heimann, Rossella Belleli, Jouni Kerman, Roland Fisch, Joseph Kahn, Sigrid Behr, Conny Berlin
Signal detection is routinely applied to spontaneous report safety databases in the pharmaceutical industry and by regulators. As an example, methods that search for increases in the frequencies of known adverse drug reactions for a given drug are routinely applied, and the results are reported to the health authorities on a regular basis. Such methods need to be sensitive to detect true signals even when some of the adverse drug reactions are rare. The methods need to be specific and account for multiplicity to avoid false positive signals when the list of known adverse drug reactions is long...
January 10, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29322264/cerebral-gray-matter-volume-in-patients-with-chronic-migraine-correlations-with-clinical-features
#8
Gianluca Coppola, Barbara Petolicchio, Antonio Di Renzo, Emanuele Tinelli, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Anna Ambrosini, Francesca Caramia, Vittorio Di Piero, Francesco Pierelli
BACKGROUND: To date, few MRI studies have been performed in patients affected by chronic migraine (CM), especially in those without medication overuse. Here, we performed magnetic resonance imaging (MRI) voxel-based morphometry (VBM) analyses to investigate the gray matter (GM) volume of the whole brain in patients affected by CM. Our aim was to investigate whether fluctuations in the GM volumes were related to the clinical features of CM. METHODS: Twenty untreated patients with CM without a past medical history of medication overuse underwent 3-Tesla MRI scans and were compared to a group of 20 healthy controls (HCs)...
December 8, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29321710/cytokine-polymorphism-and-hla-genotyping-in-patients-with-temporal-lobe-epilepsy-related-to-hippocampal-sclerosis
#9
Ayşe Altintaş, Çiğdem Özkara, Melis Sohtaoğlu Sevindik, Mustafa Uzan, Çiğdem Kekik Çinar, Ömer Uysal, Fatma Savran Oğuz
Objective: Hippocampal sclerosis (HS) is the most common pathological substrate associated with mesial temporal lobe epilepsy (MTLE), where inflammatory processes are known to play an increasingly important role in the pathogenesis. To further investigate the role of the immune system, both cytokine gene polymorphisms and human leukocyte antigen (HLA) genotyping in patients with MTLE-HS were investigated. Methods: The DNA samples of 100 patients with MTLE-HS and 201 healthy individuals were genotyped for cytokines (IL-6,IL-10, TNF-α, TGF-β1 and IFN-γ) and HLA using polymerase chain reaction (PCR)-SSP and SSO methods...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29320517/explaining-the-decline-in-coronary-heart-disease-mortality-rates-in-the-slovak-republic-between-1993-2008
#10
Marek Psota, Piotr Bandosz, Eva Gonçalvesová, Mária Avdičová, Mária Bucek Pšenková, Martin Studenčan, Jarmila Pekarčíková, Simon Capewell, Martin O'Flaherty
OBJECTIVE: Between the years 1993 and 2008, mortality rates from coronary heart disease (CHD) in the Slovak Republic have decreased by almost one quarter. However, this was a smaller decline than in neighbouring countries. The aim of this modelling study was therefore to quantify the contributions of risk factor changes and the use of evidence-based medical therapies to the CHD mortality decline between 1993 and 2008. METHODS: We identified, obtained and scrutinised the data required for the model...
2018: PloS One
https://www.readbyqxmd.com/read/29318290/ordering-effects-and-percolation-in-the-structure-formation-process-of-the-oriented-polyolefin-porous-films
#11
Galina Kazimirovna Elyashevich, Dmitrii Vladimirovich Novikov, Ivan Sergeevich Kuryndin, Andreja Jelen, Vili Bukošek
Structure transitions and mechanism of the formation of superlattices lamellae in microporous polyolefin (polyethylene and polypropylene) films obtained in the process based on polymer melt extrusion followed by annealing, uniaxial extension and thermal fixation have been studied by statistical analysis of electron microscopy images of the film surface. The structure of the porous films prepared in the multistage process has been studied by SEM, gravimetry and permeability measurements. It has been shown that the pore formation at the stage of uniaxial extension is accompanied by the ordering of lamellae and their self-organization controlled by spin draw ratio and annealing temperature...
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29316815/effect-of-l-prp-treatment-on-wound-healing-after-surgical-skin-incision-in-an-experimental-animal-model
#12
Agata Cieślik-Bielecka, Marcin Pierchała, Aleksandra Królikowska, Paweł Reichert
AIM OF THE STUDY: The aim of the study was to evaluate the effect of leukocyte- and platelet-rich plasma (L-PRP) treatment on a noncomplicated would healing after surgical skin incision in an experimental animal model. MATERIALS AND METHODS: The blood from 64 male Wistar rats was used to prepare L-PRP before a transverse dorsal incision was made and consecutively closed. At the same time after the surgery was completed, autologous L-PRP in the rats from the L-PRP group (n = 32) and NaCl in the control group (n = 32) were injected subcutaneously into the wound...
January 9, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29315787/metabolomic-serum-profiling-after-acl-injury-in-rats-a-pilot-study-implicating-inflammation-and-immune-dysregulation-in-post-traumatic-osteoarthritis
#13
Tristan Maerz, Eric Sherman, Michael Newton, Ali Yilmaz, Praveen Kumar, Stewart F Graham, Kevin C Baker
ACL rupture is a major risk factor for post-traumatic osteoarthritis (PTOA) development. Little information exists on acute systemic metabolic indicators of disease development. 36 female Lewis rats were randomized to Control or noninvasive anterior cruciate ligament rupture (ACLR) and to three post-injury time points: 72 hours, 4 weeks, 10 weeks (n = 6). Serum was collected and analyzed by 1 H nuclear magnetic resonance (NMR) spectroscopy and combined direct injection and liquid chromatography (LC)-mass spectrometry (MS)/MS (DI-MS)...
January 8, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29315421/development-of-a-new-comprehensive-and-reliable-endometrial-receptivity-map-er-map-er-grade-based-on-rt-qpcr-gene-expression-analysis
#14
M Enciso, J P Carrascosa, J Sarasa, P A Martínez-Ortiz, S Munné, J A Horcajadas, J Aizpurua
STUDY QUESTION: Is it possible to determine the receptivity status of an endometrium by combined quantitative reverse transcription PCR (RT-qPCR) expression analysis of genes involved in endometrial proliferation and immunity? SUMMARY ANSWER: The new ER Map®/ER Grade® test can predict endometrial receptivity status by RT-qPCR using a new panel of genes involved in endometrial proliferation and the maternal immune response associated to embryonic implantation. WHAT IS KNOWN ALREADY: The human endometrium reaches a receptive status adequate for embryonic implantation around Days 19-21 of the menstrual cycle...
January 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29315161/using-quality-improvement-to-increase-utilization-of-enteral-therapy-in-pediatric-crohn-disease-results-and-outcomes
#15
Ala K Shaikhkhalil, Brendan Boyle, Jennifer Smith, Jennifer L Dotson, Amy Donegan, Sandra C Kim, Ross M Maltz, Wallace Crandall
INTRODUCTION: Exclusive enteral nutrition (EEN) for induction of remission in children with Crohn's disease (CD) is recommended as first line therapy, but underutilized in the United States related to real and perceived barriers. We hypothesized that quality improvement (QI) methodology could increase use of EEN. METHODS: We developed, implemented, and revised an algorithm and a set of tools to facilitate use of EEN. Through a series of Plan Do Study Act cycles, the approach was modified to overcome provider and patient/family barriers...
January 6, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29314755/replanted-teeth-stored-in-a-newly-developed-powdered-coconut-water-formula
#16
Manuella Verdinelli de Paula Reis, Carlos José Soares, Priscilla Barbosa Ferreira Soares, Aletheia Moraes Rocha, Cristiane Clemente de Mello Salgueiro, Márcia Helena Niza Ramalho Sobral, Camilla Christian Gomes Moura
BACKGROUND/AIM: A newly developed powdered coconut water formulae (ACP-404) has been proposed to preserve periodontal ligament cell viability. The aim of this study was to investigate the periodontal healing of dog teeth replanted after storage in ACP-404 with two different osmolalities. MATERIALS AND METHODS: Sixty teeth of 10 adult beagle dogs were extracted and randomly subjected to the following protocols: immediate replantation after extraction (positive control); dry conditions (negative control); and storage in ACP-404 I (G1), ACP-404 II (G2), in coconut water long-shelf (G3), or in pH-neutralized coconut water long-shelf (G4) for 50 minutes before replantation...
January 5, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/29314192/parvalbumin-producing-striatal-interneurons-receive-excitatory-inputs-onto-proximal-dendrites-from-the-motor-thalamus-in-male-mice
#17
Yasutake Nakano, Fuyuki Karube, Yasuharu Hirai, Kenta Kobayashi, Hiroyuki Hioki, Shinichiro Okamoto, Hiroshi Kameda, Fumino Fujiyama
In rodents, the dorsolateral striatum regulates voluntary movement by integrating excitatory inputs from the motor-related cerebral cortex and thalamus to produce contingent inhibitory output to other basal ganglia nuclei. Striatal parvalbumin (PV)-producing interneurons receiving this excitatory input then inhibit medium spiny neurons (MSNs) and modify their outputs. To understand basal ganglia function in motor control, it is important to reveal the precise synaptic organization of motor-related cortical and thalamic inputs to striatal PV interneurons...
January 4, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29311568/chunking-in-working-memory-via-content-free-labels
#18
Liqiang Huang, Edward Awh
A recent study found that visual working memory performance was enhanced when pairs of colors were predictably paired, and it was interpreted as a form of "memory compression" which implies that more colors could be stored online in a more efficient format. Here we propose an alternative hypothesis that does not entail any increase in the number of individuated representations stored online. Instead, familiar ensembles of items may be attached to a content-free label (e.g., remembering red-white-blue as "American flag") that can be used to retrieve the constituents of a chunk when they are needed to guide a response...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311533/a-modern-history-of-imperial-medicine-surrounding-hansen-s-disease-strategies-to-manage-public-opinion-in-modern-japanese-media
#19
Gijae Seo
The purpose of this study is to understand the reality of imperial medicine by exploring the strategic attitude of the Japanese authority targeting the public who were not patients of Hansen's disease. For this purpose, this study examines the mass media data related to Hansen's disease published in Korea and Japan during the Japanese colonial rule. Research on Hansen's disease can be divided into medical, sociohistorical, social welfare, and human rights approach. There are medical studies and statistics on the dissemination of medical information about Hansen's disease and management measures, the history of the management of the disease, guarantee of the rights of the patients and the welfare environment, and studies on the autobiographical, literary writings and oral statements on the life and psychological conflicts of the patients...
December 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/29311009/cortical-inhibitory-function-in-cervical-dystonia
#20
Christos Ganos, Elisa R Ferrè, Angela Marotta, Panagiotis Kassavetis, John Rothwell, Kailash P Bhatia, Patrick Haggard
OBJECTIVE: To assess the specificity of cortical inhibitory deficits in cervical dystonia patients. METHODS: A systematic test battery was developed to assess spatial and temporal aspects of cortical inhibition, in motor and somatosensory systems of the hand. We tested 17 cervical dystonia (CD) patients and 19 controls assessing somatosensory spatial inhibition (grating orientation test, interdigital feedforward subliminal inhibition), somatosensory temporal inhibition (temporal discrimination threshold, feedforward subliminal inhibition), motor spatial inhibition (surround inhibition), and motor temporal inhibition (short interval intracortical inhibition)...
December 1, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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