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https://www.readbyqxmd.com/read/28514368/-the-use-of-modern-topical-medications-for-the-stepwise-treatment-of-allergic-rhinitis-the-effectiveness-and-prospects-for-the-further-extension-of-their-application
#1
E V Nosulya, I A Kim
The objective of the present work was to summarize the results of clinical studies designed to evaluate the effectiveness of 'Momate Rhino Advance' in the form of the nasal spray (based on the fixed combination of mometasone furoate and azelastine) that finds an increasingly wide application for the treatment of allergic rhinitis. The available data give evidence that this medication can be prescribed to the patients presenting with the severe and moderate form of allergic rhinitis. The treatment should be started with the use of the combined preparation and continued, after the adequate control of the clinical symptoms of allergic rhinitis is achieved, using 'Momate Rhino' during the next 2-4 weeks for the reliable management of the disease...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28474379/recent-advances-in-the-use-of-nanoparticles-for-allergen-specific-immunotherapy
#2
REVIEW
Hannah Pohlit, Iris Bellinghausen, Holger Frey, Joachim Saloga
The number of patients suffering from allergic asthma and rhino-conjunctivitis has increased dramatically within the last decades. Allergen-specific immunotherapy (AIT) is the only available cause-oriented therapy so far. AIT reduces symptoms, but has also a disease modifying effect. Disadvantages are a long-lasting procedure, and in a few cases potential systemic adverse reactions. Encapsulation of allergens or DNA vaccines into nanostructures may provide advantages compared to the conventional AIT with non-capsulated allergen extracts: The protein/DNA molecule can be protected from degradation, higher local concentrations and targeted delivery to the site of action appears possible and most importantly, recognition of encapsulated allergen by the immune system, especially by IgE antibodies is prevented...
May 5, 2017: Allergy
https://www.readbyqxmd.com/read/28468609/a-novel-trps1-mutation-in-a-moroccan-family-with-tricho-rhino-phalangeal-syndrome-type-iii-case-report
#3
W Smaili, S Chafai Elalaoui, S Meier, M Zerkaoui, A Sefiani, K Heinimann
BACKGROUND: Tricho-rhino-phalangeal syndrome (TRPS) is an autosomal dominant disorder characterized by craniofacial and skeletal malformations including short stature, thin scalp hair, sparse lateral eyebrows, pear-shaped nose and cone shaped epiphyses. This condition is caused by haploinsufficiency of the TRPS1 gene. Previous genotype-phenotype studies have correlated exon 6 missense mutations with TRPS type III, a severe form of type I with pronounced, facial characteristics, short stature and brachydactyly and differing from type II by the absence of exostoses and mental retardation...
May 3, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28457223/pepsina-as-a-marker-of-laryngopharyngeal-reflux-detected-in-chronic-rhinosinusitis-patients
#4
Jian-Jun Ren, Yu Zhao, Jing Wang, Xue Ren, Yang Xu, Wenlong Tang, Zhaoping He
Objectives We aimed to confirm the presence of pepsinA in the nasal secretions and tissues of chronic rhinosinusitis (CRS) patients and reveal the relationship between CRS and laryngopharyngeal reflux (LPR). Study Design Cross-sectional study. Setting The study was conducted at the Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University. Subjects and Methods A total of 32 CRS patients with or without nasal polyps (CRSwNP and CRSsNP, respectively) and 10 normal controls were enrolled in our study...
May 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28455592/-88th-annual-meeting-of-the-german-society-of-oto-rhino-laryngology-head-and-neck-surgery-with-good-hearing-and-without-vertigo-through-everyday-life-but-how
#5
EDITORIAL
https://www.readbyqxmd.com/read/28450941/rapidly-progressive-rhino-orbito-cerebral-mucormycosis-in-a-patient-with-type-2-diabetes-a-case-report
#6
Yan-Xia Chen, Yin-Xi He, Hong Zhou, Mian Wang, Sheng-Ou Su
With the ongoing economic development, lifestyle changes and an aging population, diabetes mellitus has be come one of the most prevalent chronic diseases in the world. Rhino-orbito-cerebral (ROC) mucormycosis is a rare, acute and angioinvasive fungal infection that can be fatal. Mucormycosis occurs exclusively in immunocompromised patients with diabetes mellitus and other types of immunodeficiency and has three subtypes: Rhino-maxillary, rhino-orbital and ROC mucormycosis. The present study reported on a case of ROC mucormycosis in a patient with diabetic ketoacidosis...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28448516/natural-variation-of-pirna-expression-affects-immunity-to-transposable-elements
#7
Sergei Ryazansky, Elizaveta Radion, Anastasia Mironova, Natalia Akulenko, Yuri Abramov, Valeriya Morgunova, Maria Y Kordyukova, Ivan Olovnikov, Alla Kalmykova
In the Drosophila germline, transposable elements (TEs) are silenced by PIWI-interacting RNA (piRNA) that originate from distinct genomic regions termed piRNA clusters and are processed by PIWI-subfamily Argonaute proteins. Here, we explore the variation in the ability to restrain an alien TE in different Drosophila strains. The I-element is a retrotransposon involved in the phenomenon of I-R hybrid dysgenesis in Drosophila melanogaster. Genomes of R strains do not contain active I-elements, but harbour remnants of ancestral I-related elements...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28434017/recurrent-epistaxis-predicting-risk-of-30-day-readmission-derivation-and-validation-of-rhino-ooze-score
#8
A Addison, C Paul, R Kuo, A Lamyman, P Martinez-Devesa, R Hettige
BACKGROUND: To derive and validate a predictive scoring tool (RHINO-ooze score) with good sensitivity and specificity in identifying patients with epistaxis at high risk of 30 day readmission and to enable risk stratification for possible definitive intervention. METHODS: Using medical databases, we searched for factors influencing recurrent epistaxis. The information ascertained together with our analysis of retrospective data on patients admitted with epistaxis between October 2013 and September 2014, was used as the derivation cohort to develop the predictive scoring model (RHINO-ooze score)...
April 23, 2017: Rhinology
https://www.readbyqxmd.com/read/28431008/diabetes-mellitus-as-the-major-risk-factor-for-mucormycosis-in-mexico-epidemiology-diagnosis-and-outcomes-of-reported-cases
#9
Dora E Corzo-León, Luis D Chora-Hernández, Ana P Rodríguez-Zulueta, Thomas J Walsh
Mucormycosis is an emerging infectious disease with high rates of associated mortality and morbidity. Little is known about the characteristics of mucormycosis or entomophthoromycosis occurring in Mexico. A search strategy was performed of literature published in journals found in available databases and theses published online at Universidad Nacional Autónoma de México (UNAM) library website reporting clinical cases or clinical case series of mucormycosis and entomophthoromycosis occurring in Mexico between 1982 and 2016...
April 20, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28420675/integrative-analysis-unveils-new-functions-for-the-drosophila-cutoff-protein-in-non-coding-rna-biogenesis-and-gene-regulation
#10
Yuri Pritykin, Tarcisio Brito, Trudi Schupbach, Mona Singh, Attilio Pane
Piwi-Interacting RNAs (piRNAs) are central components of the piRNA pathway, which directs transposon silencing and guarantees genome integrity in the germ cells of several metazoans. In Drosophila, piRNAs are produced from discrete regions of the genome termed piRNA clusters, whose expression relies on the RDC complex comprised of the core proteins Rhino, Deadlock and Cutoff. To date, the RDC complex has been exclusively implicated in the regulation of the piRNA loci. Here we further elucidate the function of Cutoff and the RDC complex by performing genome-wide ChIP-seq and RNA-seq assays in the Drosophila germline and analyzing these data together with other publicly available data sets...
April 18, 2017: RNA
https://www.readbyqxmd.com/read/28405168/the-black-evil-affecting-patients-with-diabetes-a-case-of-rhino-orbito-cerebral-mucormycosis-causing-garcin-syndrome
#11
Santhosh Narayanan, Geetha Panarkandy, Gomathy Subramaniam, Chandni Radhakrishnan, N K Thulaseedharan, Neeraj Manikath, Sreejith Ramaswamy, Suma Radhakrishnan, Danish Ekkalayil
Mucormycosis is a life-threatening infection affecting patients with diabetes. It is an angioinvasive disease often resistant to treatment with a debilitating course and high mortality. Here, we report a case of a 45 year old woman with type 2 diabetes mellitus who presented to us with history of right-sided ptosis and facial palsy, and subsequently developed loss of vision and palatal palsy. She was in diabetic ketoacidosis. Nervous system examination revealed involvement of right second, third, fourth, sixth, seventh, ninth, and tenth cranial nerves, suggestive of Garcin syndrome...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28384896/significance-of-blood-eosinophil-count-in-patients-with-chronic-rhinosinusitis-with-nasal-polyposis
#12
Ammu Sreeparvathi, Lathi Kumari Kalyanikuttyamma, Madhumita Kumar, Nandagopan Sreekumar, Narendrakumar Veerasigamani
INTRODUCTION: Chronic Rhino Sinusitis (CRS) is one of the most prevalent chronic illnesses across the globe, affecting persons of all ages. It is an inflammatory process that involves the paranasal sinuses with symptoms lasting longer than 12 weeks. AIM: To establish the significance of blood eosinophil (count) levels in CRS with nasal polyps and to compare blood eosinophil count with eosinophil count in the histopathology specimens of the polyps. MATERIALS AND METHODS: This was a retrospective study done to review the medical records of 63 patients who underwent endoscopic sinus surgery for CRS with Nasal polyps...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28367882/severe-acute-respiratory-infection-sari-surveillance-for-hospitalized-patients-in-northern-vietnam-2011-2014
#13
Hang Khanh Le Nguyen, Son Vu Nguyen, Anh Phuong Nguyen, Phuong Mai Vu Hoang, Thanh Thi Le, Thach Co Nguyen, Huong Thu Hoang, Cuong Duc Vuong, Loan Thi Thanh Tran, Le Quynh Mai
Worldwide Severe Acute Respiratory Infections (SARI) are leading causes of hospitalization, morbidity and mortality in children. The aim of this study was to identify viral pathogens responsible for SARI in northern Vietnam from 2011 to 2014. METHODS: Throat swabs and tracheal aspirates were collected from SARI patients according to WHO Guidelines. Thirteen different viral pathogens (Influenza A(H1N)pdm09; A/H3N2; A/H5; A/H7 and B; Para influenza 1,2,3; RSV; HMPV; Adeno; SARS-CoV and Rhino) were tested by conventional/ real-time RT-PCR...
March 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28358077/mapping-of-a-non-spatial-dimension-by-the-hippocampal-entorhinal-circuit
#14
Dmitriy Aronov, Rhino Nevers, David W Tank
During spatial navigation, neural activity in the hippocampus and the medial entorhinal cortex (MEC) is correlated to navigational variables such as location, head direction, speed, and proximity to boundaries. These activity patterns are thought to provide a map-like representation of physical space. However, the hippocampal-entorhinal circuit is involved not only in spatial navigation, but also in a variety of memory-guided behaviours. The relationship between this general function and the specialized spatial activity patterns is unclear...
March 29, 2017: Nature
https://www.readbyqxmd.com/read/28355466/invasive-mould-infections-in-the-icu-setting-complexities-and-solutions
#15
Matteo Bassetti, Emilio Bouza
Infections caused by filamentous fungi represent a major burden in the ICU. Invasive aspergillosis is emerging in non-neutropenic individuals with predisposing conditions, e.g. corticosteroid treatment, chronic obstructive pulmonary disease, liver cirrhosis, solid organ cancer, HIV infection and transplantation. Diagnosis is challenging because the signs and symptoms are non-specific, and initiation of additional diagnostic examinations is often delayed because clinical suspicion is low. Isolation of an Aspergillus species from the respiratory tract in critically ill patients, and tests such as serum galactomannan, bronchoalveolar lavage 1-3-β-d-glucan and specific PCR should be interpreted with caution...
March 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28330916/climate-warming-and-humans-played-different-roles-in-triggering-late-quaternary-extinctions-in-east-and-west-eurasia
#16
Xinru Wan, Zhibin Zhang
Climate change and humans are proposed as the two key drivers of total extinction of many large mammals in the Late Pleistocene and Early Holocene, but disentangling their relative roles remains challenging owing to a lack of quantitative evaluation of human impact and climate-driven distribution changes on the extinctions of these large mammals in a continuous temporal-spatial dimension. Here, our analyses showed that temperature change had significant effects on mammoth (genus Mammuthus), rhinoceros (Rhinocerotidae), horse (Equidae) and deer (Cervidae)...
March 29, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28316883/middle-pleistocene-protein-sequences-from-the-rhinoceros-genus-stephanorhinus-and-the-phylogeny-of-extant-and-extinct-middle-late-pleistocene-rhinocerotidae
#17
Frido Welker, Geoff M Smith, Jarod M Hutson, Lutz Kindler, Alejandro Garcia-Moreno, Aritza Villaluenga, Elaine Turner, Sabine Gaudzinski-Windheuser
BACKGROUND: Ancient protein sequences are increasingly used to elucidate the phylogenetic relationships between extinct and extant mammalian taxa. Here, we apply these recent developments to Middle Pleistocene bone specimens of the rhinoceros genus Stephanorhinus. No biomolecular sequence data is currently available for this genus, leaving phylogenetic hypotheses on its evolutionary relationships to extant and extinct rhinoceroses untested. Furthermore, recent phylogenies based on Rhinocerotidae (partial or complete) mitochondrial DNA sequences differ in the placement of the Sumatran rhinoceros (Dicerorhinus sumatrensis)...
2017: PeerJ
https://www.readbyqxmd.com/read/28302328/experimental-pseudomonas-aeruginosa-mediated-rhino-sinusitis-in-mink
#18
S Kirkeby, A S Hammer, N Høiby, C M Salomonsen
OBJECTIVES: The nasal and sinus cavities in children may serve as reservoirs for microorganisms that cause recurrent and chronic lung infections. This study evaluates whether the mink can be used as an animal model for studying Pseudomonas aeruginosa mediated rhino-sinusitis since there is no suitable traditional animal model for this disease. METHODS: Nasal tissue samples from infected and control mink were fixed in formalin, demineralized, and embedded in paraffin...
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28290979/orbital-cellulitis-in-a-psoriatic-patient-treated-with-adalimumab
#19
Vienna G Katana, Robert J Carpenter, John P Trafeli, Julia M Kwan
INTRODUCTION: Psoriatic patients on tumor necrosis factor alpha inhibitors (TNFi) may be at increased risk for upper respiratory tract infections, including chronic rhino-sinusitis (CRS). Rarely, CRS can progress to orbital cellulitis (OC), an emergent ophthalmic complication wherein respiratory flora from paranasal sinus disease intrude the retro-orbital space. MATERIALS AND METHODS: Single case report. RESULTS: We report the first case, to our knowledge, of an invasive sinusitis that rapidly evolved into OC in a patient receiving adalimumab treatment for plaque psoriasis and psoriatic arthritis...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28283998/anesthesia-residents-preferentially-request-operating-room-case-assignments-with-complex-cases
#20
Peggy Y Kim, Jonathan P Wanderer, David W Allbritton, Matthias Eikermann, Keith Baker
Self-directed learning is associated with knowledge and performance improvements, increased identification and amelioration of knowledge gaps, and heightened critical appraisal of available evidence. We developed and implemented a decision support system that could support self-directed learning for anesthesia residents by soliciting resident input in case selection. We hypothesized that residents would utilize this system to request complex cases, and that more advanced residents would request more complex cases...
April 2017: Journal of Medical Systems
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