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https://www.readbyqxmd.com/read/28726118/epidural-steroid-injection-related-events-requiring-hospitalisation-or-emergency-room-visits-among-52-935-procedures-performed-at-a-single-centre
#1
Joon Woo Lee, Eugene Lee, Guen Young Lee, Yusuhn Kang, Joong Mo Ahn, Heung Sik Kang
OBJECTIVES: To analyse the incidence and type of epidural steroid injection (ESI)-related adverse events, including procedure-related complications and drug-related systemic effects requiring hospitalisation or emergency room (ER) visits. METHODS: This study included 52,935 ESI procedures performed in 22,059 patients in our department from March 2004 to February 2016. Of these, we retrospectively reviewed the cases of 1570 patients (1713 procedures) who were hospitalised or visited the ER within 1 month after ESI...
July 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28721134/osteoporosis-in-men
#2
REVIEW
Waldemar Misiorowski
Osteoporotic fractures are the leading cause of morbidity and mortality among aging men. 30% of all hip fractures occur in men, and mortality resulting from not only the hip fracture, but also the spine and other major osteoporotic fractures, is significantly higher in men than in women. As in women, hypogonadism is the best documented risk factor for developing osteoporosis in men. In older men, testosterone levels are negatively correlated with the risk of fractures, and it seems that this age-related testosterone deficiency should not be considered as one of the many causes of secondary osteoporosis, rather one of the major and most important mechanisms of senile osteoporosis...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28719452/treatment-of-spinal-tumors-in-a-high-volume-center-has-direct-impact-on-local-recurrence-morbidity-and-mortality
#3
Ran Lador, Stefano Bandiera, Alessandro Gasbarrini, Riccardo Ghermandi, Stefano Boriani
OBJECTIVE OF THE STUDY: En bloc resections of spine tumors aim at locally controlling the disease for both improving the patient's quality of life as well as improving mortality. The purpose of this study was to compare the outcome between patients who were initially treated in a high volume specialized center, and patients who initially underwent either invasive diagnostic procedure or an initial surgical attempt to treat the disease in a different center. MATERIALS AND METHODS: A retrospective study of 1681 patients affected by spine tumors-treated from 1990 to 2015 by the same team...
July 17, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28719143/osteoporotic-vertebral-fracture-prevalence-varies-widely-between-radiological-assessment-methods-the-rotterdam-study
#4
L Oei, F Koromani, S J Breda, J T Schousboe, E M Clark, Jbj van Meurs, M A Ikram, J H Waarsing, Fja van Rooij, M C Zillikens, G P Krestin, Ehg Oei, F Rivadeneira
BACKGROUND: Accurate diagnosis of vertebral osteoporotic fractures is crucial for the identification of individuals at high risk of future fractures. Different methods for radiological assessment of vertebral fractures exist, but a gold standard is lacking. The aim of our study was to estimate statistical measures of agreement and prevalence of osteoporotic vertebral fractures in the population-based Rotterdam Study, across the two most commonly applied assessment methods. METHODS: The quantitative morphometry (QM) method, evaluates vertebral height loss that affects vertebral shape whereas the algorithm based qualitative (ABQ) method judges endplate integrity and includes guidelines for the differentiation of vertebral fracture and non- fracture deformities...
July 18, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28717153/proton-pump-inhibitors-and-the-risk-for-fracture-at-specific-sites-data-mining-of-the-fda-adverse-event-reporting-system
#5
Liwei Wang, Mei Li, Yuying Cao, Zhengqi Han, Xueju Wang, Elizabeth J Atkinson, Hongfang Liu, Shreyasee Amin
Proton pump inhibitors (PPIs) are widely used to treat gastric acid-related disorders. Concerns have been raised about potential fracture risk, especially at the hip, spine and wrist. However, fracture risk at other bone sites has not been as well studied. We investigated the association between PPIs and specific fracture sites using an aggregated knowledge-enhanced database, the Food and Drug Administration Adverse Event Reporting System Data Mining Set (AERS-DM). Proportional reporting ratio (PRR) was used to detect statistically significant associations (signals) between PPIs and fractures...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715798/bone-mineral-density-in-women-living-with-complete-androgen-insensitivity-syndrome-and-intact-testes-or-removed-gonads
#6
Silvano Bertelloni, Maria C Meriggiola, Elenora Dati, Antonio Balsamo, Giampiero I Baroncelli
Complete androgen insensitivity syndrome (CAIS) is due to complete androgen resistance in androgen-dependent tissues. Since androgens are involved in growth, development, and mass maintenance of the skeleton, bone health may be a relevant clinical issue for improving quality of life of women living with CAIS. Bone mineral density (BMD) in women with CAIS and intact gonads has been reported in a normal range, although exceptions are known showing a low BMD mainly at the lumbar level. In women with CAIS and removed gonads, BMD is usually reduced at both the lumbar spine and femoral neck...
July 18, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28712984/quantitative-computed-tomography-current-status-and-new-developments
#7
Klaus Engelke
This review focuses on new developments and current controversies in the field of quantitative computed tomography. Recent positions of the International Society for Clinical Densitometry acknowledged the clinical value of quantitative computed tomography of the spine and the hip using clinical whole-body computed tomography (CT) scanners. Opportunistic screening summarizes a number of new approaches describing the dual use of clinical CT scans. For example, CT scans may have been taken for tumor diagnosis but may also be used for the prediction of high or low fracture risks as an additional benefit for the patient...
July 13, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28712898/iatrogenic-vertebral-artery-injury-during-anterior-cervical-spine-surgery-a-systematic-review
#8
REVIEW
Qing Guan, Long Chen, Ye Long, Zhou Xiang
BACKGROUND: Iatrogenic vertebral artery injury (VAI) during anterior cervical surgery is rare but potentially catastrophic. METHOD: The causes, presentation, diagnosis, management, prognosis, and prevention of VAI were reviewed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. English-language studies and case reports published from 1980 to 2017 were retrieved. Data on diagnosis, surgical procedures and approach, site and cause of VAI, management, outcomes, and VA status were extracted...
July 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28712877/bone-mass-microarchitecture-and-strength-are-influenced-by-race-ethnicity-in-young-adult-men-and-women
#9
Kristin L Popp, Julie M Hughes, Adriana Martinez-Betancourt, Matthew Scott, Victoria Turkington, Signe Caksa, Katelyn I Guerriere, Kathryn E Ackerman, Chun Xu, Ginu Unnikrishnan, Jaques Reifman, Mary L Bouxsein
Lower rates of fracture in both Blacks compared to Whites, and men compared to women are not completely explained by differences in bone mineral density (BMD). Prior evidence suggests that more favorable cortical bone microarchitecture may contribute to reduced fracture rates in older Black compared to White women, however it is not known whether these differences are established in young adulthood or develop during aging. Moreover, prior studies using high-resolution pQCT (HR-pQCT) have reported outcomes from a fixed-scan location, which may confound sex- and race/ethnicity-related differences in bone structure...
July 13, 2017: Bone
https://www.readbyqxmd.com/read/28704623/process-of-change-in-pain-related-fear-clinical-insights-from-a-single-case-of-persistent-back-pain-managed-with-cognitive-functional-therapy
#10
J P Caneiro, Anne Smith, Martin Rabey, G Lorimer Moseley, Peter O'Sullivan
Study Design Single-case report with repeated measures over 18 months. Background Management of persistent low back pain (PLBP) associated with high pain-related fear is complex. This single-case report aims to provide clinicians with an insight to the process of change in a person with PLBP and high bending-related fear, managed with an individualized behavioral approach - Cognitive Functional Therapy (CFT). Case Description A retired manual worker with PLBP believed that his spine was degenerating, that bending would hurt him and avoidance was the only form of pain control...
July 13, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28700413/venous-thromboembolism-after-major-venous-injuries-competing-priorities
#11
Brian Frank, Zoё Maher, Joshua P Hazelton, Shelby Resnick, Elizabeth Dauer, Anna Goldenberg, Andrea L Lubitz, Brian P Smith, Noelle N Saillant, Patrick M Reilly, Mark J Seamon
BACKGROUND: Venous thromboembolism (VTE) after major vascular injury (MVI) is particularly challenging as the competing risk of thrombosis and embolization after direct vessel injury must be balanced with risk of bleeding after surgical repair. We hypothesized that venous injuries, repair type and intraoperative anticoagulation would influence VTE formation after MVI. METHODS: A multi-institution, retrospective cohort study of consecutive MVI patients was conducted at 3 urban, level-I centers (2005-2013)...
July 12, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28699789/real-world-effectiveness-of-daily-teriparatide-in-japanese-patients-with-osteoporosis-at-high-risk-for-fracture-final-results-from-the-24-month-japan-fracture-observational-study-jfos
#12
Satoshi Soen, Saeko Fujiwara, Ryoichi Takayanagi, Kenta Kajimoto, Mika Tsujimoto, Shuichi Kimura, Masayo Sato, John H Krege, Hiroyuki Enomoto
OBJECTIVE: The Japan Fracture Observational Study (JFOS), a prospective observational study, investigated the real-world effectiveness of daily teriparatide to reduce clinical fracture risk in osteoporotic patients. METHODS: In routine clinical practice, Japanese patients initiated on teriparatide 20 μg/day by subcutaneous injection were enrolled. The primary endpoint was the rate of clinical fractures at 6-month intervals over 24 months. Bone mineral density (BMD), procollagen type 1 aminoterminal propeptide (P1NP), back pain, and health-related quality of life (HRQoL) information was collected...
July 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28692172/effect-of-monthly-high-dose-vitamin-d-on-bone-density-in-community-dwelling-older-adults-sub-study-of-a-randomized-controlled-trial
#13
Ian R Reid, Anne M Horne, Borislav Mihov, Gregory D Gamble, Fadiya Al-Abuwsi, Manisha Singh, Lucie Taylor, Sheryl Fenwick, Carlos A Camargo, Alistair W Stewart, Robert Scragg
BACKGROUND: Severe vitamin D deficiency causes osteomalacia, yet trials of vitamin D supplementation in the community have not on average demonstrated benefit to bone mineral density (BMD) or fracture risk in adults. OBJECTIVE: To determine whether monthly high-dose vitamin D supplementation influences BMD in the general population and in those with low 25-hydroxyvitamin D levels. METHODS: 2-year sub-study of a trial in older community-resident adults...
July 10, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28688984/patient-profiling-can-identify-adult-spinal-deformity-asd-patients-at-risk-for-conversion-from-nonoperative-to-surgical-treatment-initial-steps-to-reduce-ineffective-asd-management
#14
Peter G Passias, Cyrus M Jalai, Breton G Line, Gregory W Poorman, Justin K Scheer, Justin S Smith, Christopher I Shaffrey, Douglas C Burton, Kai-Ming G Fu, Eric O Klineberg, Robert A Hart, Frank Schwab, Virginie Lafage, Shay Bess
BACKGROUND CONTEXT: Non-operative management is a common initial treatment for adult spinal deformity (ASD) patients despite reported superiority of surgery with regard to outcomes. Ineffective medical care is a large source of resource drain on the health system. Characterization of ASD patients likely to elect for operative treatment from nonoperative management may allow for more efficient patient counseling and cost savings. PURPOSE: To identify deformity and disability characteristics of ASD patients that ultimately convert to operative treatment compared to those that remain non-operative and those that initially choose surgery...
July 5, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28687288/does-collimation-affect-patient-dose-in-antero-posterior-thoraco-lumbar-spine
#15
J B Robinson, R M Ali, A K Tootell, P Hogg
INTRODUCTION: The purpose of this study is to determine the effect of collimation on the lifetime attributable risk (LAR) of cancer incidence in all body organs (effective risk) in patients undergoing antero-posterior (AP) examinations of the spine. This is of particular importance for patients suffering from scoliosis as in their case regular repeat examinations are required and also because such patients are usually young and more susceptible to the effects of ionising radiation than are older patients...
August 2017: Radiography
https://www.readbyqxmd.com/read/28685282/bone-mineral-density-in-adults-with-down-syndrome
#16
A Carfì, R Liperoti, D Fusco, S Giovannini, V Brandi, D L Vetrano, E Meloni, D Mascia, E R Villani, E Manes Gravina, R Bernabei, G Onder
This study analyzed data of bone mineral density (BMD) from a large cohort of adults with Down syndrome (DS). BMD was found to decrease with age more rapidly in these subjects than in the general population, exposing adults with DS to an increased risk of osteoporosis and bone fracture. INTRODUCTION: Down syndrome (DS) in adulthood presents with a high prevalence of osteoporosis. However, in DS, bone mineral density (BMD) can be underestimated due to short stature. Furthermore, the rate of age-related decline in BMD and its association with gender in DS has been rarely evaluated or compared with the general population...
July 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28681751/assessment-of-surgical-risk-factors-in-the-development-of-ventilator-associated-pneumonia-in-neurosurgical-intensive-care-unit-patients-alarming-observations
#17
Deepashu Sachdeva, Daljit Singh, Poonam Loomba, Amandeep Kaur, Monica Tandon, Ishu Bishnoi
BACKGROUND: Ventilator-associated pneumonia (VAP) is the most frequent nosocomial infection in patients receiving mechanical ventilation (MV) and contributes to a longer intensive care unit (ICU) stay, duration of MV, and a high morbidity and mortality. OBJECTIVE: The purpose of study was to determine the incidence of VAP in neurosurgery ICU patients and to assess the probable contributing neurosurgical risk factors like the site and nature of the lesion in the brain, the duration of surgery, blood loss during surgery, and infection elsewhere in the body, in the development of VAP...
July 2017: Neurology India
https://www.readbyqxmd.com/read/28678610/occupant-responses-in-conventional-and-abts-seats-in-high-speed-rear-sled-tests
#18
David C Viano, Chantal S Parenteau, Roger Burnett, Priya Prasad
OBJECTIVE: This study compared biomechanical responses of a normally seated Hybrid III dummy on conventional and ABTS (all belts to seat) seats in 40.2 km/h (25 mph) rear sled tests. It determined the difference in performance with modern (≥2000 MY) seats compared to older (<2000 MY) seats and ABTS seats. METHODS: The seats were fixed in a sled buck subjected to a 40.2 km/h (25 mph) rear sled test. The pulse was a 15 g double-peak acceleration with 150 ms duration...
July 5, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28673825/the-medico-legal-landscape-of-spine-surgery-how-do-surgeons-fare
#19
Melvin C Makhni, Paul J Park, Jesus Jimenez, Comron S Saifi, Jon-Michael Caldwell, Alex Ha, Bianca Figueroa-Santana, Ronald A Lehman, Mark Weidenbaum
BACKGROUND CONTEXT: Due to the limited and confidential nature of most legal data, scarce literature is available to physicians about reasons for litigation in spine surgery. In order to optimally compensate patients while protecting physicians, further understanding of the medico-legal landscape is needed for high-risk procedures such as spine surgery. Based on these, surgeons can explore ways to better protect both their patients and themselves. PURPOSE: To characterize the current medico-legal environment of spine surgery by analyzing a recent dataset of malpractice litigation...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28670414/use-of-allogenic-mesenchymal-cellular-bone-matrix-in-anterior-and-posterior-cervical-spinal-fusion-a-case-series-of-21-patients
#20
Srikanth Naga Divi, Mark M Mikhael
STUDY DESIGN: Retrospective case series. PURPOSE: To report our early experience using allogenic mesenchymal cellular bone matrix (CBM) products in cervical spine fusion. OVERVIEW OF LITERATURE: Multi-level cervical fusions have historically yielded lower fusion rates than single level fusions, especially in patients with high risk medical comorbidities. At this time, significant literature in cervical fusion outcomes with this cellular allograft technology is lacking...
June 2017: Asian Spine Journal
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