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https://www.readbyqxmd.com/read/29222074/changes-of-oxygen-consumption-and-heart-rate-after-acute-myocardial-infarction-during-6-month-follow-up
#1
Yuri Choe, Jae-Young Han, In-Sung Choi, Hyeng-Kyu Park
BACKGROUND: Exercise intensity is a particularly important determinant of physiological responses to exercise training in patients with acute myocardial infarction. Heart rate (HR) is commonly used as a practical way of prescribing and monitoring exercise as specific intensities based on linear relationship between the percentage of maximum heart rate (%HRmax) and the percentage of maximum oxygen consumption (%VO2max) regardless of age, sex or exercise mode. OBJECTIVE: To examine the change in variability in the correlation between %HRmax and %VO2maxafter acute myocardial infarction...
December 5, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29168997/a-retrospective-audit-of-in-hospital-30-day-mortality-from-acute-myocardial-infarction-in-connolly-hospital-blanchardstown
#2
M Hensey, M Cronin, E Keelan, J O'Neill, J Galvin
In 2015, The Department of Health published the first annual report of the "National Healthcare Quality Reporting System." Connolly Hospital was reported to a mortality rate within 30 days post-Acute Myocardial Infarction (AMI) of 9.87 per 100 cases which was statistically significantly higher than the national rate. We carried out a retrospective audit of patients who were HIPE-coded as having died within 30 days of AMI from 2011-2013 and identified 42 patients. On review, only 23 patients (54.8%) were confirmed as having had an AMI...
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29168080/cardioprotective-effects-of-morroniside-in-rats-following-acute-myocardial-infarction
#3
Bangxing Yu, Wen Wang
The aim of this study is to investigate the cardioprotective effects of morroniside in rats following acute myocardial infarction. An acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD) [1]. Following AMI, morroniside was administered intragastrically for 24 h at doses of 45, 90, and 180 mg/kg, respectively. Biomarkers such as creatine kinase (CK-MB), lactate dehydrogenase (LDH), ɑ-hydroxybutyrate dehydrogenase (ɑ-HBDH), and aspartate aminotransferase (AST) activities in AMI rats in the serum were detected with commercial kits [2]...
November 22, 2017: Inflammation
https://www.readbyqxmd.com/read/29141241/mmp-9-and-its-regulators-timp-1-and-emmprin-in-patients-with-acute-st-elevation-myocardial-infarction-a-nordistemi-substudy
#4
Trine Baur Opstad, Ingebjørg Seljeflot, Ellen Bøhmer, Harald Arnesen, Sigrun Halvorsen
OBJECTIVES: The extracellular matrix is involved in wound repair after acute myocardial infarction (AMI). We investigated whether matrix metalloproteinase (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1, and the MMP inducer (EMMPRIN) are associated with infarct size, left ventricular function, and clinical outcome in ST-elevation-MI (STEMI). METHODS: In 243 STEMI patients, circulating EMMPRIN, MMP-9, and TIMP-1 were analyzed 3 days and 3 months post-AMI...
November 16, 2017: Cardiology
https://www.readbyqxmd.com/read/29119710/role-of-sdf-1-cxcr4-in-impaired-post-myocardial-infarction-cardiac-repair-in-diabetes
#5
Maritza E Mayorga, Matthew Kiedrowski, Patricia McCallinhart, Farhad Forudi, Jeremiah Ockunzzi, Kristal Weber, William Chilian, Marc S Penn, Feng Dong
Diabetes is a risk factor for worse outcomes following acute myocardial infarction (AMI). In this study, we tested the hypothesis that SDF-1:CXCR4 expression is compromised in post-AMI in diabetes, and that reversal of this defect can reverse the adverse effects of diabetes. Mesenchymal stem cells (MSC) isolated from green fluorescent protein (GFP) transgenic mice (control MSC) were induced to overexpress stromal cell-derived factor-1 (SDF-1). SDF-1 expression in control MSC and SDF-1-overexpressing MSC (SDF-1:MSC) were quantified using enzyme-linked immunosorbent assay (ELISA)...
November 9, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29098407/cytoprotective-effects-of-transgenic-neuroglobin-overexpression-in-an-acute-and-chronic-mouse-model-of-ischemic-heart-disease
#6
Evi Luyckx, Bert R Everaert, Bieke Van der Veken, Wendy Van Leuven, Jean-Pierre Timmermans, Christiaan J Vrints, Guido R Y De Meyer, Wim Martinet, Sylvia Dewilde
Neuroglobin (NGB) is an oxygen-binding protein that is mainly expressed in nervous tissues where it is considered to be neuroprotective during ischemic brain injury. Interestingly, transgenic mice overexpressing NGB reveal cytoprotective effects on tissues lacking endogenous NGB, which might indicate a therapeutic role for NGB in a broad range of ischemic conditions. In the present study, we investigated the effect of NGB overexpression on survival as well as on the size and occurrence of myocardial infarctions (MI) in a mouse model of acute MI (AMI) and a model of advanced atherosclerosis (ApoE (-/-) Fbn1 (C1039G+/-) mice), in which coronary plaques and MI develop in mice being fed a Western-type diet...
November 2, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29053758/sex-differences-in-long-term-mortality-among-acute-myocardial-infarction-patients-results-from-the-isar-risk-and-art-studies
#7
Romy Ubrich, Petra Barthel, Bernhard Haller, Katerina Hnatkova, Katharina Maria Huster, Alexander Steger, Alexander Müller, Marek Malik, Georg Schmidt
BACKGROUND: Mortality rates in females who survived acute myocardial infarction (AMI) exceed those in males. Differences between sexes in age, cardiovascular risk factors and revascularization therapy have been proposed as possible reasons. OBJECTIVE: To select sets of female and male patients comparable in respect of relevant risk factors in order to compare the sex-specific risk in a systematic manner. METHODS: Data of the ISAR-RISK and ART studies were investigated...
2017: PloS One
https://www.readbyqxmd.com/read/29051213/changes-in-statin-adherence-following-an-acute-myocardial-infarction-among-older-adults-patient-predictors-and-the-association-with-follow-up-with-primary-care-providers-and-or-cardiologists
#8
Ryan P Hickson, Jennifer G Robinson, Izabela E Annis, Ley A Killeya-Jones, Maarit Jaana Korhonen, Ashley L Cole, Gang Fang
BACKGROUND: Hospitalizations for acute myocardial infarctions (AMIs) are associated with changes in statin adherence. It is unclear to what extent adherence changes, which patients are likely to change, and how post-discharge follow-up is associated with statin adherence change. METHODS AND RESULTS: This retrospective study used Medicare data for all fee-for-service beneficiaries 66 years and older with an AMI hospitalization in 2008-2010 and statin use before their index AMI...
October 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29040445/rationale-and-design-of-the-effectiveness-of-lower-maintenance-dose-of-ticagrelor-early-after-myocardial-infarction-electra-pilot-study
#9
Jacek Kubica, Piotr Adamski, Katarzyna Buszko, Aldona Kubica, Wiktor Kuliczkowski, Tomasz Fabiszak, Bernd Jilma, Dimitrios Alexopoulos, Przemyslaw Paciorek, Eliano P Navarese
BackgroundThe degree and time course of platelet inhibition using ticagrelor can vary during the acute phase and the following stable period after acute myocardial infarction (AMI). The optimal level of platelet inhibition during the various stages of AMI remains an open question. The aim of the current study is to compare the antiplatelet efficacy of two ticagrelor maintenance dose regimens (60 mg b.i.d. vs 90 mg b.i.d.) in stable patients following an initial strategy with ticagrelor 90 mg b.i.d. during the first month after AMI...
October 10, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29037256/effects-of-timing-on-intracoronary-autologous-bone-marrow-derived-cell-transplantation-in-acute-myocardial-infarction-a-meta-analysis-of-randomized-controlled-trials
#10
Jia-Ying Xu, Dai Liu, Yang Zhong, Rong-Chong Huang
BACKGROUND: Several cell-based therapies for adjunctive treatment of acute myocardial infarction have been investigated in multiple clinical trials, but the timing of transplantation remains controversial. We conducted a meta-analysis of randomized controlled trials to investigate the effects of timing on bone marrow-derived cell (BMC) therapy in acute myocardial infarction (AMI). METHODS: A systematic literature search of PubMed, MEDLINE, and Cochrane Evidence-Based Medicine databases from January 2000 to June 2017 was performed on randomized controlled trials with at least a 3-month follow-up for patients with AMI undergoing emergency percutaneous coronary intervention (PCI) and receiving intracoronary BMC transfer thereafter...
October 16, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28865892/comparison-of-readmission-rates-after-acute-myocardial-infarction-in-3-patient-age-groups-18-to-44-45-to-64-and-%C3%A2-65-years-in-the-united-states
#11
MULTICENTER STUDY
Rohan Khera, Snigdha Jain, Ambarish Pandey, Vijay Agusala, Dharam J Kumbhani, Sandeep R Das, Jarett D Berry, James A de Lemos, Saket Girotra
Postacute myocardial infarction (AMI) readmissions are common among Medicare beneficiaries (≥65 years) and are associated with significant resource utilization. However, patterns of AMI readmissions for younger age groups in the United States are not known. In the Nationwide Readmissions Database, a nationally representative all-payer database of inpatient hospitalizations, we identified 212,171 index AMI hospitalizations in January to November 2013, weighted to represent 478,247 hospitalizations nationally (mean age 66...
November 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28783513/platelet-toll-like-receptor-tlr-expression-and-tlr-mediated-platelet-activation-in-acute-myocardial-infarction
#12
Kathryn E Hally, Anne C La Flamme, Peter D Larsen, Scott A Harding
Both platelets and Toll-like receptors (TLRs) contribute to acute myocardial infarction (AMI). Platelet activation can occur post-AMI and despite treatment with anti-platelet therapy. TLRs may represent an alternative platelet activation pathway, although the role of platelet-TLRs in AMI is poorly characterized. The aim of this study was to examine platelet-TLR expression and TLR-mediated platelet activation in healthy and AMI subjects. Here, we report that platelets from AMI patients exhibit upregulation of some, but not other, TLRs...
August 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28727670/effect-of-psychosocial-and-vocational-interventions-on-return-to-work-rates-post-acute-myocardial-infarction-a-systematic-review
#13
Lisa OʼBrien, Sonal Wallace, Lorena Romero
PURPOSE: To examine whether the effects of psychosocial and vocational interventions delivered in the first 3 mo post-acute myocardial infarction (AMI) are effective for improving work outcomes compared with other interventions. METHODS: A search was completed for English language publications up to March 2016 across 4 electronic databases and gray literature. Inclusion criteria were (1) psychosocial and/or vocational interventions; (2) adults 18 years or older with an AMI who were within the first 3 mo post-AMI; (3) randomized or clinically controlled trials; and (4) reporting of at least 1 return-to-work (RTW) outcome: including return to paid/unpaid employment, either full-time or part-time, to the previous job role or on modified duties...
July 19, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28697641/erectile-dysfunction-in-young-myocardial-infarction-survivors-evaluation-follow-up
#14
Gabriela Dostálová, Zuzana Hlubocká, Kristýna Bayerová, Jan Bělohlávek, Aleš Linhart, Debora Karetová
Erectile dysfunction significantly affects quality of life in young men. Authors have evaluated erectile function in men with coronary artery disease (CAD) and the relationship between the degree of erectile dysfunction (ED) and the age of their first acute myocardial infarction (AMI). The incidence of erectile dysfunction in three groups of patients of AMI survivors was investigated: AMI survivors younger than 45 years, AMI survivors older than 65 years, and normal male population aged between 30 and 60 years...
November 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28686722/the-changes-of-gut-microbiota-after-acute-myocardial-infarction-in-rats
#15
Ze-Xuan Wu, Su-Fang Li, Hong Chen, Jun-Xian Song, Yuan-Feng Gao, Feng Zhang, Cheng-Fu Cao
Recent studies suggested that gut microbiota was involved in the development of coronary artery disease. However, the changes of gut microbiota following acute myocardial infarction (AMI) remain unknown. In this study, a total of 66 male Wistar rats were randomly divided into control, AMI and SHAM groups. The controls (n = 6) were sacrificed after anesthesia. The AMI model was built by ligation of left anterior descending coronary artery. The rats of AMI and SHAM groups were sacrificed at 12 h, 1 d, 3 d, 7 d and 14 d post-operation respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28663047/diagnostic-and-prognostic-value-of-mir-1-and-mir-29b-on-adverse-ventricular-remodeling-after-acute-myocardial-infarction-the-sitagrami-mir-analysis
#16
U Grabmaier, S Clauss, L Gross, I Klier, W M Franz, G Steinbeck, R Wakili, H D Theiss, C Brenner
BACKGROUND: MicroRNAs (miRs) have shown to exert fibrotic and anti-fibrotic effects in preclinical models of acute myocardial infarction (AMI). The aim of this study was to evaluate miR-1, miR-21, miR-29b and miR-92a as circulating biomarkers for adverse ventricular remodeling (AVR) in post-AMI patients. METHODS: Plasma levels of miR-1, miR-21, miR-29b and miR-92a were measured in 44 patients of the SITAGRAMI trial population at day 4, day 9 and 6month after AMI and in 18 matched controls (CTL)...
June 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28576268/comparison-of-1-2-and-6-month-readmission-rates-in-patients-with-acute-myocardial-infarction-directly-admitted-to-hospital-versus-transferred-from-another-hospital-to-an-academic-medical-center
#17
COMPARATIVE STUDY
Jeffrey P Chidester, Ellen C Keeley
Patients with acute myocardial infarction (AMI) who are transferred are less likely than directly admitted patients to receive outpatient follow-up within 30 days and are more likely to be readmitted. In 2015, we launched a clinic where post-AMI patients (direct admits and transfers) are seen within 1 week of hospital discharge. We compared short- and long-term clinical outcomes of patients who were transferred to patients who were directly admitted to our institution to determine the impact of transfer status on early outpatient follow-up and clinical outcomes...
August 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28490433/peripheral-blood-cytokine-levels-after-acute-myocardial-infarction-il-1%C3%AE-and-il-6-related-impairment-of-bone-marrow-function
#18
Mahan Shahrivari, Elizabeth Wise, Micheline Resende, Jonathan J Shuster, Jingnan Zhang, Roberto Bolli, John P Cooke, Joshua M Hare, Timothy D Henry, Aisha Khan, Doris A Taylor, Jay H Traverse, Phillip C Yang, Carl J Pepine, Christopher R Cogle
RATIONALE: Intracoronary infusion of bone marrow (BM) mononuclear cells after acute myocardial infarction (AMI) has led to limited improvement in left ventricular function. Although experimental AMI models have implicated cytokine-related impairment of progenitor cell function, this response has not been investigated in humans. OBJECTIVE: To test the hypothesis that peripheral blood (PB) cytokines predict BM endothelial progenitor cell colony outgrowth and cardiac function after AMI...
June 9, 2017: Circulation Research
https://www.readbyqxmd.com/read/28444175/predictive-value-of-telomere-length-on-outcome-following-acute-myocardial-infarction-evidence-for-contrasting-effects-of-vascular-vs-blood-oxidative-stress
#19
Marios Margaritis, Fabio Sanna, George Lazaros, Ioannis Akoumianakis, Sheena Patel, Alexios S Antonopoulos, Chloe Duke, Laura Herdman, Costas Psarros, Evangelos K Oikonomou, Cheerag Shirodaria, Mario Petrou, Rana Sayeed, George Krasopoulos, Regent Lee, Dimitris Tousoulis, Keith M Channon, Charalambos Antoniades
Aims: Experimental evidence suggests that telomere length (TL) is shortened by oxidative DNA damage, reflecting biological aging. We explore the value of blood (BTL) and vascular TL (VTL) as biomarkers of systemic/vascular oxidative stress in humans and test the clinical predictive value of BTL in acute myocardial infarction (AMI). Methods and results: In a prospective cohort of 290 patients surviving recent AMI, BTL measured on admission was a strong predictor of all-cause [hazard ratio (HR) [95% confidence interval (CI)]: 3...
November 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28400035/percutaneous-closure-of-post-myocardial-infarction-ventricular-septal-rupture-a-single-centre-experience
#20
Rajendra Kumar Premchand, Ravikanth Garipalli, T N C Padmanabhan, Geetesh Manik
BACKGROUND: Post-infarction ventricular septal rupture (VSR) is a rare but lethal mechanical complication of an acute myocardial infarction (AMI). Survival to 1 month without intervention is 6%. Given high surgical mortality, transcatheter closure has emerged as a potential strategy in selected cases. Indian data on percutaneous device closure of post AMI-VSR is scarce hence we report our single-centre experience with ASD occluder device (Amplatzer and lifetech) for closure of post-AMI VSR...
April 2017: Indian Heart Journal
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