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https://www.readbyqxmd.com/read/28205256/quality-of-life-coping-strategies-social-support-and-self-efficacy-in-women-after-acute-myocardial-infarction-a-mixed-methods-approach
#1
G Fuochi, C Foà
BACKGROUND: Quality of life, coping strategies, social support and self-efficacy are important psychosocial variables strongly affecting the experience of acute myocardial infarction (AMI) in women. AIMS: To gain a more in-depth understanding of how coping strategies, self-efficacy, quality of life and social support shape women's adjustment to AMI. DESIGN: Mixed methods study. Quantitative data were collected through a standardised questionnaire on coping strategies, self-efficacy, quality of life and social support...
February 15, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28164501/circulating-mir-208b-a-potentially-sensitive-and-reliable-biomarker-for-the-diagnosis-and-prognosis-of-acute-myocardial-infarction
#2
Xiaoxiao Liu, Ling Yuan, Fang Chen, Lizhu Zhang, Xi Chen, Chengjian Yang, Zhijun Han
BACKGROUND: MicroRNAs are present in human plasma and have been reported to be biomarkers for cardiovascular diseases. The aim of this study was to investigate the value of circulating microRNA-208b (miR-208b) for the diagnosis and prognosis of acute myocardial infarction (AMI). METHODS: A total of 100 AMI patients, 80 unstable angina (UA) patients, and 80 healthy controls (HCs) were consecutively included in this study. Plasma was collected from each participant on admission, and the levels of circulating miR-208b were measured using reverse transcription-polymerase chain reaction (RT-PCR)...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28150462/tongxinluo-exerts-protective-effects-via-anti-apoptotic-and-pro-autophagic-mechanisms-by-activating-ampk-pathway-in-infarcted-rat-hearts
#3
Qing Li, Na Li, He-He Cui, Xia-Qiu Tian, Chen Jin, Gui-Hao Chen, Yue-Jin Yang
Tongxinluo (TXL) has been demonstrated to have a protective role during ischemia/reperfusion after acute myocardial infarction (AMI), but the long-term effects and the underlying mechanisms are still unknown. This study aimed to investigate whether TXL could have an effect on apoptosis or autophagy of cardiomyocytes through the AMP-activated protein kinase (AMPK) pathway. Male, Sprague-Dawley rats (n = 75) were randomly divided to sham, control, TXL (4 mg kg(-1)  d(-1) orally), compound C (intraperitoneal injection at 10 mg kg(-1)  d(-1) ), and TXL + compound C groups...
February 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28138705/resveratrol-activates-endogenous-cardiac-stem-cells-and-improves-myocardial-regeneration-following-acute-myocardial-infarction
#4
Lin Ling, Shaohua Gu, Yan Cheng
Stem cell antigen-1-positive (Sca-1+) cardiac stem cells (CSCs) therapy for myocardial regeneration following acute myocardial infarction (AMI) is limited by insufficient cell viability and a high rate of apoptosis, due to the poor regional microenvironment. Resveratrol, which is a compound extracted from red wine, has been reported to protect myocardial tissue post‑AMI by increasing the expression of angiogenic and chemotactic factors. The present study aimed to investigate the effects of resveratrol on Sca‑1+ CSCs, and to optimize Sca‑1+ CSCs therapy for myocardial regeneration post‑AMI...
January 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28129708/learned-helplessness-and-depressive-symptoms-following-myocardial-infarction
#5
Benjamin A Smallheer, Michael Vollman, Mary S Dietrich
Psychosocial factors are known to impact depressive symptoms across clinical populations. Learned helplessness has the potential of affecting depressive symptoms following acute myocardial infarction (AMI), though little is known about this relationship. The purpose of this study was to examine the relationship between learned helplessness and depressive symptoms in patients following an AMI. Using a descriptive cross-sectional design, participants with a diagnosed AMI within the past 12 months were recruited...
January 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28069838/incidence-of-atrial-fibrillation-detected-by-continuous-rhythm-monitoring-after-acute-myocardial-infarction-in-patients-with-preserved-left-ventricular-ejection-fraction-results-of-the-arrest-study
#6
Alexander Romanov, Martin Martinek, Helmut Pürerfellner, Shaojie Chen, Mirko De Melis, Igor Grazhdankin, Dmitry Ponomarev, Denis Losik, Artem Strelnikov, Vitaliy Shabanov, Alexander Karaskov, Evgeny Pokushalov
AIMS: Cardiac arrhythmias following acute myocardial infarction (AMI) can be associated with major adverse cardiovascular events. Data on the "real incidence" of post-MI arrhythmias are limited. We aimed to determine the rate and burden of cardiac arrhythmias by the use of insertable cardiac monitors (ICM) in patients with preserved left ventricular ejection fraction (LVEF) after AMI. METHODS AND RESULTS: In this prospective observational study, patients with LVEF ≥40% who underwent PCI within 7 days following AMI were enrolled to receive an ICM...
January 8, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28061883/multimodality-cardiac-imaging-of-a-left-ventricular-papillary-fibroelastoma-a-case-report
#7
Rajat Sharma, Mehrdad Golian, Pallav Shah, Davinder S Jassal, Nasir Shaikh
BACKGROUND: In the setting of an acute myocardial infarction (AMI), although the most common etiology of a left ventricular (LV) mass identified on multimodality cardiovascular imaging is a thrombus, other possibilities including a vegetation or tumor should be entertained within the differential diagnosis. CASE PRESENTATION: We describe a case of a 43-year-old Caucasian female post AMI diagnosed with a mid-cavitary mass within the LV. Although echocardiography and cardiovascular MRI (CMR) suggested that the mass was a thrombus, given the context of the recent AMI, exploration and surgical excision was completed by the surgeon due to the potential for the mass to embolize...
January 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/27984507/perceived-stress-after-acute-myocardial-infarction-a-comparison-between-young-and-middle-aged-women-versus-men
#8
Xiao Xu, Haikun Bao, Kelly M Strait, Donald E Edmondson, Karina W Davidson, John F Beltrame, Héctor Bueno, Haiqun Lin, Rachel P Dreyer, John E Brush, John A Spertus, Judith H Lichtman, Gail DʼOnofrio, Harlan M Krumholz
OBJECTIVE: The aim of the study was to examine how psychological stress changes over time in young and middle-aged patients after experiencing an acute myocardial infarction (AMI) and whether these changes differ between men and women. METHODS: We analyzed data obtained from 2358 women and 1151 men aged 18 to 55 years hospitalized for AMI. Psychological stress was measured using the 14-item Perceived Stress Scale (PSS-14) at initial hospitalization and at 1 month and 12 months after AMI...
January 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27967213/could-nlrp3-inflammasome-be-a-cardiovascular-risk-biomarkers-in-acute-myocardial-infarction-patients
#9
Pedro Bullon, Francisco J Cano-García, Elisabet Alcocer-Gómez, Alfonso Varela-Lopez, Lourdes Román-Malo, Rafael J Ruiz-Salmerón, Jose L Quiles, Jose M Navarro-Pando, Maurizio Battino, Jesús Ruiz-Cabello, Luis J Jiménez-Borreguero, Mario D Cordero
Conventional cardiovascular risk factors (CVRF) are accepted to identify asymptomatic individuals with high risk of acute myocardial infarction (AMI). However, AMI affects many patients previously classified at low risk. New biomarkers are needed to improve risk prediction. We propose to evaluate the NLRP3-inflammasome complex as a potential CVR indicator in healthy males and post-AMI patients and compare both groups by known CVRFs. We included 109 men with no history of cardiovascular disease (controls) and 150 AMI patients attending a cardiac rehabilitation program...
December 14, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27913007/higher-post-acute-myocardial-infarction-plasma-haptoglobin-level-is-associated-with-poor-long-term-overall-survival
#10
Kuang-Hsing Chiang, Yung-Ta Kao, Hsin-Bang Leu, Po-Hsun Huang, Shao-Sung Huang, Tsai-Mu Cheng, Ju-Pin Pan
AIM: To evaluate the association of post-acute myocardial infarction (AMI) plasma haptoglobin (Hp) levels with long-term overall survival in AMI patients. METHODS AND RESULTS: Patients who were diagnosed of AMI were recruited and their Hp phenotypes and plasma levels were determined. According to previously reported cutoff point for Hp level (288.4ng/ml), patients were classified as higher Hp group (>288.4ng/ml) and lower Hp group (≤288.4ng/ml). The primary outcome was overall survival...
February 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27861719/beta-blocker-use-in-u-s-nursing-home-residents-after-myocardial-infarction-a-national-study
#11
Andrew R Zullo, Yoojin Lee, Lori A Daiello, Vincent Mor, W John Boscardin, David D Dore, Yinghui Miao, Kathy Z Fung, Kiya D R Komaiko, Michael A Steinman
OBJECTIVES: To evaluate how often beta-blockers were started after acute myocardial infarction (AMI) in nursing home (NH) residents who previously did not use these drugs and to evaluate which factors were associated with post-AMI use of beta-blockers. DESIGN: Retrospective cohort using linked national Minimum Data Set assessments; Online Survey, Certification and Reporting records; and Medicare claims. SETTING: U.S. NHs. PARTICIPANTS: National cohort of 15,720 residents aged 65 and older who were hospitalized for AMI between May 2007 and March 2010, had not taken beta-blockers for at least 4 months before their AMI, and survived 14 days or longer after NH readmission...
November 15, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27856230/a-comparison-in-therapeutic-efficacy-of-several-time-points-of-intravenous-stembell-administration-in-a-rat-model-of-acute-myocardial-infarction
#12
Reindert W Emmens, Maikel Oedayrajsingh-Varma, Linde Woudstra, Otto Kamp, Elisa Meinster, Annemieke van Dijk, Marco N Helder, Diana Wouters, Sacha Zeerleder, S Marieke van Ham, Nico de Jong, Hans W M Niessen, Lynda J M Juffermans, Paul A J Krijnen
BACKGROUND: Adipose-derived stromal cells (ASCs) are a promising new therapeutic option for patients with acute myocardial infarction (AMI). Previously, we found that ASCs coupled to antibody-targeted microbubbles (StemBells [StBs]) improved cardiac function when administered intravenously 7 days post-AMI in rats. In this study, we compared the efficacy of intravenous StB administration at different administration time points following AMI in rats. METHODS: AMI, followed by reperfusion, was induced in four groups of male Wistar rats, which subsequently received an intravenous 1 × 10(6) StB bolus 1 day post-AMI (StB1; n = 8), 7 days post-AMI (StB7; n = 9), at both time points (StB1+7; n = 7) or neither (Control; n = 7)...
January 2017: Cytotherapy
https://www.readbyqxmd.com/read/27833128/qishen-granules-inhibit-myocardial-inflammation-injury-through-regulating-arachidonic-acid-metabolism
#13
Chun Li, Jing Wang, Qiyan Wang, Yi Zhang, Na Zhang, Linghui Lu, Yan Wu, Qian Zhang, Wei Wang, Yong Wang, Pengfei Tu
Qishen granules (QSG), a traditional Chinese medicine, have been prescribed widely in the treatment of coronary heart diseases. Previous studies demonstrated that QSG had anti-inflammatory and cardio-protective effects in mice with acute myocardial infarction (AMI). However, the mechanisms by which QSG attenuate inflammation and prevent post-AMI heart failure (HF) are still unclear. In this study, we explored the anti-inflammatory mechanisms of QSG by in vitro and in vivo experiments. A novel inflammatory injury model of H9C2 cells was induced by lipopolysaccharide (LPS)-stimulated macrophage-conditioned media (CM)...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27810412/on-the-value-of-therapeutic-interventions-targeting-the-complement-system-in-acute-myocardial-infarction
#14
REVIEW
Reindert W Emmens, Diana Wouters, Sacha Zeerleder, S Marieke van Ham, Hans W M Niessen, Paul A J Krijnen
The complement system plays an important role in the inflammatory response subsequent to acute myocardial infarction (AMI). The aim of this study is to create a systematic overview of studies that have investigated therapeutic administration of complement inhibitors in both AMI animal models and human clinical trials. To enable extrapolation of observations from included animal studies toward post-AMI clinical trials, ex vivo studies on isolated hearts and proof-of-principle studies on inhibitor administration before experimental AMI induction were excluded...
October 14, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27798417/efficacy-of-zofenopril-compared-with-placebo-and-other-angiotensin-converting-enzyme-inhibitors-in-patients-with-acute-myocardial-infarction-and-previous-cardiovascular-risk-factors-a-pooled-individual-data-analysis-of-4-randomized-double-blind-controlled-prospective
#15
Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni
In the Survival of Myocardial Infarction Long-term Evaluation (SMILE) 1, 3, and 4 studies, early administration of zofenopril in acute myocardial infarction showed to be prognostically beneficial versus placebo or ramipril. The SMILE-2 showed that both zofenopril and lisinopril are safe and showed no significant differences in the incidence of major cardiovascular (CV) complications. In this pooled analysis of individual data of the SMILE studies, we evaluated whether the superior efficacy of zofenopril is maintained also in patients with ≥1 CV risk factor (CV+, n = 2962) as compared to CV- (n = 668)...
January 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27764157/long-term-outcome-of-combined-percutaneous-intramyocardial-and-intracoronary-application-of-autologous-bone-marrow-mononuclear-cells-post-myocardial-infarction-the-5-year-mystar-study
#16
Mariann Gyöngyösi, Georgiana-Aura Giurgea, Bonni Syeda, Silvia Charwat, Beatrice Marzluf, Julia Mascherbauer, Andras Jakab, Abelina Zimba, Márta Sárközy, Noemi Pavo, Heinz Sochor, Senta Graf, Irene Lang, Gerald Maurer, Jutta Bergler-Klein
OBJECTIVE: The long-term (5-year) outcome of early (3-6 weeks after acute myocardial infarction [AMI], BM-MNC Early group) and late (3-4 months after AMI, BM-MNC Late group) combined (percutaneous intramyocardial and intracoronary) delivery of autologous bone marrow mononuclear cells (BM-MNCs) was evaluated in patients with ejection fractions (EF) between 30-45% post-AMI. METHODS: Major adverse cardiac and cerebrovascular events (MACCE) and hospitalization were recorded...
2016: PloS One
https://www.readbyqxmd.com/read/27742618/sex-differences-in-financial-barriers-and-the-relationship-to-recovery-after-acute-myocardial-infarction
#17
Adam L Beckman, Emily M Bucholz, Weiwei Zhang, Xiao Xu, Rachel P Dreyer, Kelly M Strait, John A Spertus, Harlan M Krumholz, Erica S Spatz
BACKGROUND: Financial barriers to health care are associated with worse outcomes following acute myocardial infarction (AMI). Yet, it is unknown whether the prevalence of financial barriers and their relationship with post-AMI outcomes vary by sex among young adults. METHODS AND RESULTS: We assessed sex differences in patient-reported financial barriers among adults aged <55 years with AMI using data from the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients study...
October 14, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27708111/zofenopril-and-ramipril-in-patients-with-left-ventricular-systolic-dysfunction-after-acute-myocardial-infarction-a-propensity-analysis-of-the-survival-of-myocardial-infarction-long-term-evaluation-smile-4-study
#18
Claudio Borghi, Stefano Omboni, Salvatore Novo, Dragos Vinereanu, Giuseppe Ambrosio, Ettore Ambrosioni
INTRODUCTION: This was a propensity score analysis of the prospective, randomized, double-blind Survival of Myocardial Infarction Long-term Evaluation (SMILE) 4 study in which one-year treatment with zofenopril 60 mg plus acetylsalicylic acid (ASA) 100 mg gave superior results compared to ramipril 10 mg plus ASA in terms of death or hospitalization for cardiovascular causes in patients with acute myocardial infarction (AMI) complicated by left ventricular dysfunction (LVD). MATERIALS AND METHODS: A total of 716 patients of the intention-to-treat population were divided into homogeneous propensity quintiles (Q) using a logistic regression model (QI: best risk profile; QV: worst risk profile)...
October 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27692757/life-years-gained-from-smoking-cessation-counseling-after-myocardial-infarction
#19
Emily M Bucholz, Adam L Beckman, Catarina I Kiefe, Harlan M Krumholz
INTRODUCTION: Hospitalization for acute myocardial infarction (AMI) is an opportune time to counsel smokers to quit. Studies have demonstrated lower short-term mortality for counseled versus non-counseled smokers; yet, little is known about the long-term survival benefits of post-AMI smoking-cessation counseling (SCC). METHODS: Data from the Cooperative Cardiovascular Project, a prospective cohort study of elderly patients with AMI between 1994 and 1996 with >17 years of follow-up, were used to evaluate the association of SCC with short- and long-term mortality in smokers with AMI...
January 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27439601/sustained-quality-of-life-improvement-after-intracoronary-injection-of-autologous-bone-marrow-cells-in-the-setting-of-acute-myocardial-infarction-results-from-the-bonami-trial
#20
Guillaume Lamirault, Elodie de Bock, Véronique Sébille, Béatrice Delasalle, Jérôme Roncalli, Sophie Susen, Christophe Piot, Jean-Noël Trochu, Emmanuel Teiger, Yannick Neuder, Thierry Le Tourneau, Alain Manrique, Jean-Benoît Hardouin, Patricia Lemarchand
PURPOSE: Cardiac cell therapy is a promising treatment for acute myocardial infarction (AMI), leading to cardiac function improvement. However, whether it translates into quality of life (QoL) improvement is unclear. We hypothesized that administration of bone marrow cells (BMC) to patients with AMI improves QoL. METHODS: In the multicenter BONAMI trial (NCT00200707), patients with reperfused AMI and decreased myocardial viability were randomized to intracoronary autologous BMC infusion (n = 52) or state-of-the-art therapy (n = 49)...
January 2017: Quality of Life Research
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