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https://www.readbyqxmd.com/read/27861719/beta-blocker-use-in-u-s-nursing-home-residents-after-myocardial-infarction-a-national-study
#1
Andrew R Zullo, Yoojin Lee, Lori A Daiello, Vincent Mor, W John Boscardin, David D Dore, Yinghui Miao, Kathy Z Fung, Kiya D R Komaiko, Michael A Steinman
OBJECTIVES: To evaluate how often beta-blockers were started after acute myocardial infarction (AMI) in nursing home (NH) residents who previously did not use these drugs and to evaluate which factors were associated with post-AMI use of beta-blockers. DESIGN: Retrospective cohort using linked national Minimum Data Set assessments; Online Survey, Certification and Reporting records; and Medicare claims. SETTING: U.S. NHs. PARTICIPANTS: National cohort of 15,720 residents aged 65 and older who were hospitalized for AMI between May 2007 and March 2010, had not taken beta-blockers for at least 4 months before their AMI, and survived 14 days or longer after NH readmission...
November 15, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27856230/a-comparison-in-therapeutic-efficacy-of-several-time-points-of-intravenous-stembell-administration-in-a-rat-model-of-acute-myocardial-infarction
#2
Reindert W Emmens, Maikel Oedayrajsingh-Varma, Linde Woudstra, Otto Kamp, Elisa Meinster, Annemieke van Dijk, Marco N Helder, Diana Wouters, Sacha Zeerleder, S Marieke van Ham, Nico de Jong, Hans W M Niessen, Lynda J M Juffermans, Paul A J Krijnen
BACKGROUND: Adipose-derived stromal cells (ASCs) are a promising new therapeutic option for patients with acute myocardial infarction (AMI). Previously, we found that ASCs coupled to antibody-targeted microbubbles (StemBells [StBs]) improved cardiac function when administered intravenously 7 days post-AMI in rats. In this study, we compared the efficacy of intravenous StB administration at different administration time points following AMI in rats. METHODS: AMI, followed by reperfusion, was induced in four groups of male Wistar rats, which subsequently received an intravenous 1 × 10(6) StB bolus 1 day post-AMI (StB1; n = 8), 7 days post-AMI (StB7; n = 9), at both time points (StB1+7; n = 7) or neither (Control; n = 7)...
November 14, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27833128/qishen-granules-inhibit-myocardial-inflammation-injury-through-regulating-arachidonic-acid-metabolism
#3
Chun Li, Jing Wang, Qiyan Wang, Yi Zhang, Na Zhang, Linghui Lu, Yan Wu, Qian Zhang, Wei Wang, Yong Wang, Pengfei Tu
Qishen granules (QSG), a traditional Chinese medicine, have been prescribed widely in the treatment of coronary heart diseases. Previous studies demonstrated that QSG had anti-inflammatory and cardio-protective effects in mice with acute myocardial infarction (AMI). However, the mechanisms by which QSG attenuate inflammation and prevent post-AMI heart failure (HF) are still unclear. In this study, we explored the anti-inflammatory mechanisms of QSG by in vitro and in vivo experiments. A novel inflammatory injury model of H9C2 cells was induced by lipopolysaccharide (LPS)-stimulated macrophage-conditioned media (CM)...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27810412/on-the-value-of-therapeutic-interventions-targeting-the-complement-system-in-acute-myocardial-infarction
#4
REVIEW
Reindert W Emmens, Diana Wouters, Sacha Zeerleder, S Marieke van Ham, Hans W M Niessen, Paul A J Krijnen
The complement system plays an important role in the inflammatory response subsequent to acute myocardial infarction (AMI). The aim of this study is to create a systematic overview of studies that have investigated therapeutic administration of complement inhibitors in both AMI animal models and human clinical trials. To enable extrapolation of observations from included animal studies toward post-AMI clinical trials, ex vivo studies on isolated hearts and proof-of-principle studies on inhibitor administration before experimental AMI induction were excluded...
October 14, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27798417/efficacy-of-zofenopril-compared-to-placebo-and-other-ace-inhibitors-in-patients-with-acute-myocardial-infarction-and-previous-cardiovascular-risk-factors-a-pooled-individual-data-analysis-of-four-randomized-double-blind-controlled-prospective-studies
#5
Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni
In the SMILE 1, 3 and 4 studies early administration of zofenopril in acute myocardial infarction (AMI) showed to be prognostically beneficial vs. placebo or ramipril. The SMILE-2 showed that both zofenopril and lisinopril are safe and showed no significant differences in the incidence of major cardiovascular complications. In this pooled analysis of individual data of the SMILE studies we evaluated whether the superior efficacy of zofenopril is maintained also in patients with ≥1 cardiovascular risk factor (CV+, n=2962) as compared to CV- (n=668)...
October 7, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27764157/long-term-outcome-of-combined-percutaneous-intramyocardial-and-intracoronary-application-of-autologous-bone-marrow-mononuclear-cells-post-myocardial-infarction-the-5-year-mystar-study
#6
Mariann Gyöngyösi, Georgiana-Aura Giurgea, Bonni Syeda, Silvia Charwat, Beatrice Marzluf, Julia Mascherbauer, Andras Jakab, Abelina Zimba, Márta Sárközy, Noemi Pavo, Heinz Sochor, Senta Graf, Irene Lang, Gerald Maurer, Jutta Bergler-Klein
OBJECTIVE: The long-term (5-year) outcome of early (3-6 weeks after acute myocardial infarction [AMI], BM-MNC Early group) and late (3-4 months after AMI, BM-MNC Late group) combined (percutaneous intramyocardial and intracoronary) delivery of autologous bone marrow mononuclear cells (BM-MNCs) was evaluated in patients with ejection fractions (EF) between 30-45% post-AMI. METHODS: Major adverse cardiac and cerebrovascular events (MACCE) and hospitalization were recorded...
2016: PloS One
https://www.readbyqxmd.com/read/27742618/sex-differences-in-financial-barriers-and-the-relationship-to-recovery-after-acute-myocardial-infarction
#7
Adam L Beckman, Emily M Bucholz, Weiwei Zhang, Xiao Xu, Rachel P Dreyer, Kelly M Strait, John A Spertus, Harlan M Krumholz, Erica S Spatz
BACKGROUND: Financial barriers to health care are associated with worse outcomes following acute myocardial infarction (AMI). Yet, it is unknown whether the prevalence of financial barriers and their relationship with post-AMI outcomes vary by sex among young adults. METHODS AND RESULTS: We assessed sex differences in patient-reported financial barriers among adults aged <55 years with AMI using data from the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients study...
October 14, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27708111/zofenopril-and-ramipril-in-patients-with-left-ventricular-systolic-dysfunction-after-acute-myocardial-infarction-a-propensity-analysis-of-the-survival-of-myocardial-infarction-long-term-evaluation-smile-4-study
#8
Claudio Borghi, Stefano Omboni, Salvatore Novo, Dragos Vinereanu, Giuseppe Ambrosio, Ettore Ambrosioni
INTRODUCTION: This was a propensity score analysis of the prospective, randomized, double-blind Survival of Myocardial Infarction Long-term Evaluation (SMILE) 4 study in which one-year treatment with zofenopril 60 mg plus acetylsalicylic acid (ASA) 100 mg gave superior results compared to ramipril 10 mg plus ASA in terms of death or hospitalization for cardiovascular causes in patients with acute myocardial infarction (AMI) complicated by left ventricular dysfunction (LVD). MATERIALS AND METHODS: A total of 716 patients of the intention-to-treat population were divided into homogeneous propensity quintiles (Q) using a logistic regression model (QI: best risk profile; QV: worst risk profile)...
October 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27692757/life-years-gained-from-smoking-cessation-counseling-after-myocardial-infarction
#9
Emily M Bucholz, Adam L Beckman, Catarina I Kiefe, Harlan M Krumholz
INTRODUCTION: Hospitalization for acute myocardial infarction (AMI) is an opportune time to counsel smokers to quit. Studies have demonstrated lower short-term mortality for counseled versus non-counseled smokers; yet, little is known about the long-term survival benefits of post-AMI smoking-cessation counseling (SCC). METHODS: Data from the Cooperative Cardiovascular Project, a prospective cohort study of elderly patients with AMI between 1994 and 1996 with >17 years of follow-up, were used to evaluate the association of SCC with short- and long-term mortality in smokers with AMI...
September 28, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27439601/sustained-quality-of-life-improvement-after-intracoronary-injection-of-autologous-bone-marrow-cells-in-the-setting-of-acute-myocardial-infarction-results-from-the-bonami-trial
#10
Guillaume Lamirault, Elodie de Bock, Véronique Sébille, Béatrice Delasalle, Jérôme Roncalli, Sophie Susen, Christophe Piot, Jean-Noël Trochu, Emmanuel Teiger, Yannick Neuder, Thierry Le Tourneau, Alain Manrique, Jean-Benoît Hardouin, Patricia Lemarchand
PURPOSE: Cardiac cell therapy is a promising treatment for acute myocardial infarction (AMI), leading to cardiac function improvement. However, whether it translates into quality of life (QoL) improvement is unclear. We hypothesized that administration of bone marrow cells (BMC) to patients with AMI improves QoL. METHODS: In the multicenter BONAMI trial (NCT00200707), patients with reperfused AMI and decreased myocardial viability were randomized to intracoronary autologous BMC infusion (n = 52) or state-of-the-art therapy (n = 49)...
July 20, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27357314/s100a1-transgenic-treatment-of-acute-heart-failure-causes-proteomic-changes-in-rats
#11
Yichen Guo, Lianqun Cui, Shiliang Jiang, Dongmei Wang, Shu Jiang, Chen Xie, Yanping Jia
S100 Ca2+-binding protein A1 (S100A1) is an important regulator of myocardial contractility. The aim of the present study was to identify the underlying mechanisms of S100A1 activity via profiling the protein expression in rats administered with an S100A1 adenovirus (Ad‑S100A1‑EGFP) following acute myocardial infarction (AMI). LTQ OrbiTrap mass spectrometry was used to profile the protein expression in the Ad‑S100A1‑EGFP and control groups post‑AMI. Using Protein Analysis Through Evolutionary Relationships (PANTHER) analysis, 134 energy metabolism‑associated proteins, which comprised 20 carbohydrate metabolism‑associated and 27 lipid metabolism associated proteins, were identified as differentially expressed in the Ad‑S100A1‑EGFP hearts compared with controls...
August 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27333818/the-wearable-cardioverter-defibrillator-as-a-bridge-to-implantable-defibrillator-post-myocardial-infarction-what-do-we-know
#12
Alon Barsheshet, Theodora Vamvouris, Ilan Goldenberg
INTRODUCTION: Ventricular tachyarrhythmias (ventricular tachycardia and ventricular fibrillation) can lead to aborted cardiac arrest or sudden cardiac death in patients with poor left ventricular function early after acute myocardial infarction (AMI). Although it has been shown that the implantable cardioverter defibrillator (ICD) can treat ventricular tachyarrhythmias and save lives in patients with ischemic cardiomyopathy, it's use during the early phase post AMI has not been shown to reduce mortality...
July 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27315099/coffee-reduces-the-risk-of-death-after-acute-myocardial-infarction-a-meta-analysis
#13
Oliver I Brown, Victoria Allgar, Kenneth Y-K Wong
BACKGROUND: Habitual coffee consumption is protective against coronary heart disease in women; however, it is not clear whether such cardioprotection is conferred on those who have already experienced an acute myocardial infarction (AMI). Our aim was to investigate whether coffee consumption affected mortality after AMI. MATERIALS AND METHODS: We carried out a dose-response meta-analysis of prospective studies that examined the relationship between coffee intake and mortality after an AMI...
November 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27312076/ivabradine-in-patients-with-st-elevation-myocardial-infarction-complicated-by-cardiogenic-shock-a-preliminary-randomized-prospective-study
#14
Francesco Barillà, Giuseppe Pannarale, Concetta Torromeo, Vincenzo Paravati, Maria Cristina Acconcia, Gaetano Tanzilli, Enrico Mangieri, Tania Dominici, Francesco Martino, Gaetano Pannitteri, Carlo Gaudio
BACKGROUND AND OBJECTIVE: An elevated heart rate (HR) is an independent risk factor for mortality and morbidity in patients with acute heart failure (HF). The purpose of this study was to evaluate the impact of ivabradine, a selective HR-lowering agent, in patients with cardiogenic shock (CS) complicating ST-elevation acute myocardial infarction (AMI). METHODS: Patients with post-AMI CS were randomized to standard treatment (SDT, 28 patients) or to standard treatment plus ivabradine (I + SDT, 30 patients)...
October 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27257851/decreased-admission-serum-albumin-level-is-an-independent-predictor-of-long-term-mortality-in-hospital-survivors-of-acute-myocardial-infarction-soroka-acute-myocardial-infarction-ii-sami-ii-project
#15
Ygal Plakht, Harel Gilutz, Arthur Shiyovich
BACKGROUND: Decreased serum albumin level (SAL) was reported to be associated with increased risk of cardiovascular events and short term-mortality in patients with acute myocardial infarction (AMI). OBJECTIVES: To evaluate the association between SAL and long-term mortality in AMI hospital survivors. METHODS: Retrospective analysis of patients admitted in a tertiary medical center for AMI 2002-2012 and discharged alive. EXCLUSION CRITERIA: active infections, inflammatory diseases, significant liver or kidney failure, malignancy, ejection-fraction <20%, severe heart valvular-disease and missing SAL...
September 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27186654/development-of-a-new-therapeutic-technique-to-direct-stem-cells-to-the-infarcted-heart-using-targeted-microbubbles-stembells
#16
L Woudstra, P A J Krijnen, S J P Bogaards, E Meinster, R W Emmens, T J A Kokhuis, I A E Bollen, H Baltzer, S M T Baart, R Parbhudayal, M N Helder, V W M van Hinsbergh, R J P Musters, N de Jong, O Kamp, H W M Niessen, A van Dijk, L J M Juffermans
Successful stem cell therapy after acute myocardial infarction (AMI) is hindered by lack of engraftment of sufficient stem cells at the site of injury. We designed a novel technique to overcome this problem by assembling stem cell-microbubble complexes, named 'StemBells'. StemBells were assembled through binding of dual-targeted microbubbles (~3μm) to adipose-derived stem cells (ASCs) via a CD90 antibody. StemBells were targeted to the infarct area via an ICAM-1 antibody on the microbubbles. StemBells were characterized microscopically and by flow cytometry...
July 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27165094/mechanism-based-pharmacokinetic-pharmacodynamic-modeling-of-salvianolic-acid-a-effects-on-plasma-xanthine-oxidase-activity-and-uric-acid-levels-in-acute-myocardial-infarction-rats
#17
Haidong Wang, Xi Li, Wenting Zhang, Yao Liu, Shijun Wang, Xiaoquan Liu, Hua He
1. Salvianolic acid A (SalA) was found to attenuate plasma uric acid (UA) concentration and xanthine oxidase (XO) activity in acute myocardial infraction (AMI) rats, which was characterized with developed mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) model. 2. AMI was induced in rats by coronary artery ligation. Surviving AMI rats received a single intravenous dose of 5 mg/kg of SalA and normal saline. The plasma SalA concentrations were determined by HPLC-MS/MS method. The plasma UA concentrations were determined by HPLC method and plasma XO activity were measured spectrophotometrically...
May 11, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27152932/ambient-fine-particulate-matter-and-mortality-among-survivors-of-myocardial-infarction-population-based-cohort-study
#18
Hong Chen, Richard T Burnett, Ray Copes, Jeffrey C Kwong, Paul J Villeneuve, Mark S Goldberg, Robert D Brook, Aaron van Donkelaar, Michael Jerrett, Randall V Martin, Jeffrey R Brook, Alexander Kopp, Jack V Tu
BACKGROUND: Survivors of acute myocardial infarction (AMI) are at increased risk of dying within several hours to days following exposure to elevated levels of ambient air pollution. Little is known, however, about the influence of long-term (months to years) air pollution exposure on survival after AMI. OBJECTIVE: We conducted a population-based cohort study to determine the impact of long-term exposure to fine particulate matter ≤ 2.5 μm in diameter (PM2.5) on post-AMI survival...
September 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27126533/inflammation-as-a-driver-of-adverse-left%C3%A2-ventricular-remodeling-after-acute-myocardial-infarction
#19
REVIEW
Peter C Westman, Michael J Lipinski, Dror Luger, Ron Waksman, Robert O Bonow, Edwin Wu, Stephen E Epstein
Treatment of acute myocardial infarction (AMI) has improved significantly in recent years, but many patients have adverse left ventricular (LV) remodeling, a maladaptive change associated with progressive heart failure. Although this change is usually associated with large infarcts, some patients with relatively small infarcts have adverse remodeling, whereas other patients with larger infarcts (who survive the first several days after AMI) do not. This paper reviews the relevant data supporting the hypothesis that individual differences in the intensity of the post-AMI inflammatory response, involving 1 or more inflammatory-modulating pathways, may contribute to adverse LV remodeling...
May 3, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27002251/variables-associated-with-disability-in-male-and-female-long-term-survivors-from-acute-myocardial-infarction-results-from-the-monica-kora-myocardial-infarction-registry
#20
Inge Kirchberger, Margit Heier, Ute Amann, Bernhard Kuch, Christian Thilo, Christa Meisinger
Increasing attention is paid on functional limitations and disability among people with chronic diseases. However, only few studies have explored disability in persons with acute myocardial infarction (AMI). The objective of this study was to provide a description of disability and to identify determinants of disability in a population-based sample of long-term AMI survivors. The sample consisted of 1943 persons (35-85years) with AMI from the German population-based MONICA/KORA Myocardial Infarction Registry, who responded to a postal follow-up survey in 2011...
July 2016: Preventive Medicine
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