Wenqing Mu, Guang Xu, Ziying Wei, Zhilei Wang, Qin Qin, Li Lin, Lutong Ren, Tingting Liu, Zhie Fang, Yan Yang, Jing Zhao, Junnan Wang, Xiaoyan Zhan, Xiaohe Xiao, Zhaofang Bai
Increased medical application of psychotropic drugs raised attention concerning their toxicological effects. In fact, more than 160 psychotropic drugs including antidepressants and antipsychotics, have been shown to cause liver side effects, but the underlying mechanisms are still poorly understood. Here, we discovered that fluoxetine, a common antidepressant, was specifically sensed by NLRP3 inflammasome, whose subsequent activation resulted in the maturation of caspase-1 and IL-1β, as well as gasdermin D (GSDMD) cleavage, which could be completely abrogated by a selective NLRP3 inhibitor MCC950 or Nlrp3 knockout (Nlrp3-/- )...
July 9, 2022: Cell Death Discovery