Read by QxMD icon Read

lyophilized plasma review

Justin J J Watson, Shibani Pati, Martin A Schreiber
Traumatic hemorrhage is the leading cause of preventable death after trauma. Early transfusion of plasma and balanced transfusion have been shown to optimize survival, mitigate the acute coagulopathy of trauma, and restore the endothelial glycocalyx. There are a myriad of plasma formulations available worldwide, including fresh frozen plasma, thawed plasma, liquid plasma, plasma frozen within 24 h, and lyophilized plasma (LP). Significant equipoise exists in the literature regarding the optimal plasma formulation...
November 2016: Shock
Anthony E Pusateri, Michael B Given, Martin A Schreiber, Philip C Spinella, Shibani Pati, Rosemary A Kozar, Abdul Khan, Joseph A Dacorta, Kevin R Kupferer, Nicolas Prat, Heather F Pidcoke, Victor W Macdonald, Wilbur W Malloy, Anne Sailliol, Andrew P Cap
The early transfusion of plasma is important to ensure optimal survival of patients with traumatic hemorrhage. In military and remote or austere civilian settings, it may be impossible to move patients to hospital facilities within the first few hours of injury. A dried plasma product with reduced logistical requirements is needed to enable plasma transfusion where medically needed, instead of only where freezers and other equipment are available. First developed in the 1930s, pooled lyophilized plasma was widely used by British and American forces in WWII and the Korean War...
April 2016: Transfusion
Kenichi A Tanaka, Michael Mazzeffi, Miroslav Durila
Prothrombin complex concentrate (PCC) is a term to describe pharmacological products that contain lyophilized, human plasma-derived vitamin K-dependent factors (F), FII, FVII, FIX, FX, and various amounts of proteins C and S. PCCs can be rapidly reconstituted in a small volume (20 ml for about 500 international units (IU)) at bedside and administered regardless of the patient's blood type. PCCs are categorized as 4-factor PCC if they contain therapeutic amounts of FVII, and 3-factor PCC when FVII content is low...
2014: Journal of Intensive Care
Tor Hervig, Silje Kaada, Jerard Seghatchian
The storage and handling conditions of cellular blood components and plasma are often rigorous, which is causing extensive discard of components that may be of acceptable quality as the rules for “out of optimal storage conditions” seem to be based more on tradition than scientific investigations. This short review summarizes some of the key papers indicating that it should be time for reconsideration of these rules, and some new suggestions are carefully indicated. Red cell concentrates, platelet concentrates and FFP are considered;lyophilized plasma and never-frozen liquid plasma are not included in this paper...
October 2014: Transfusion and Apheresis Science
M Carcao
Beginning in the 1960s the care of persons with haemophilia began to improve dramatically through a series of transformative improvements in care: development of lyophilized factor concentrates, home care programmes, prophylaxis and (due to the tragedy of HIV/hepatitis) the development of virally safer plasma-derived and recombinant factor concentrates. Prophylaxis, if commenced early and given in sufficient dose/frequency has been shown to allow persons with haemophilia to maintain excellent joints and lead normal lives...
May 2014: Haemophilia: the Official Journal of the World Federation of Hemophilia
Rajoshi Chaudhuri, Yuan Cheng, C Russell Middaugh, David B Volkin
Stabilization and formulation of therapeutic proteins against physical instability, both structural alterations and aggregation, is particularly challenging not only due to each protein's unique physicochemical characteristics but also their susceptibility to the surrounding milieu (pH, ionic strength, excipients, etc.) as well as various environmental stresses (temperature, agitation, lyophilization, etc.). The use of high-throughput techniques can significantly aid in the evaluation of stabilizing solution conditions by permitting a more rapid evaluation of a large matrix of possible combinations...
January 2014: AAPS Journal
Kristen Zeitler, Brian Salvas, Vanessa Stevens, Jack Brown
PURPOSE: The pharmacology, safety, efficacy, pharmacokinetics, pharmacodynamics, current place in therapy, and potential future therapeutic uses of inhaled aztreonam are reviewed. SUMMARY: Inhaled aztreonam, a newly formulated lysine salt of the original monobactam antibiotic, is approved for the treatment of respiratory symptoms in patients with cystic fibrosis (CF) who are colonized with Pseudomonas aeruginosa. Its spectrum of activity is limited to susceptible gram-negative organisms, including P...
January 15, 2012: American Journal of Health-system Pharmacy: AJHP
Jerrold H Levy, Fania Szlam, Kenichi A Tanaka, Roman M Sniecienski
Fibrinogen plays several key roles in the maintenance of hemostasis. Its cleavage by thrombin and subsequent polymerization to form fibrin strands provides the structural network required for effective clot formation. During cases of acute blood loss, attempts to maintain circulating volume and tissue perfusion often involve the infusion of crystalloids, colloids, and red blood cells. Intravascular volume resuscitation, although vital, frequently results in dilution of the remaining clotting factors and onset of dilutional coagulopathy...
February 2012: Anesthesia and Analgesia
Joanna Zdziarska, Krzysztof Chojnowski, Anna Klukowska, Magdalena Łetowska, Andrzej Mital, Maria Podolak-Dawidziak, Jerzy Windyga, Krystyna Zawilska et al.
Advances in hemophilia management in the 20th century enabled effective and early treatment of joint and other bleeds typical of this disease, also in a home setting. Prophylaxis became available as the optimal approach to prevent hemophilic arthropathy and improve patients' quality of life. To increase treatment safety, lyophilized plasma-derived factor VIII and IX concentrates were subjected to numerous procedures designed to decrease the risk of transmission of known and unknown pathogens. During the following years, recombinant factor VIII and factor IX preparations were developed to completely eliminate the risk...
June 2009: Polskie Archiwum Medycyny Wewnętrznej
Meaghan Sullivan, Kristine Hahn, Jill M Kolesar
PURPOSE: The pharmacology, pharmacokinetics, clinical efficacy, dosage and administration, and safety of azacitidine are reviewed. SUMMARY: Azacitidine is the first drug in a new class of compounds, known as DNA hypomethylating agents, to receive FDA-approved labeling for the treatment of myelodysplastic syndromes. It exerts its antineoplastic activity by causing a direct cytotoxic effect on abnormally proliferating hematopoietic cell lines by interfering with nucleic acid metabolism...
August 1, 2005: American Journal of Health-system Pharmacy: AJHP
E G Bovill, J McDonagh, D A Triplett, C F Arkin, J T Brandt, T E Hayes, E Kaczmarek, T Long, W A Rock
Plasma fibrinogen concentration appears to be an important risk factor for the development of atherosclerotic cardiovascular disease of a similar magnitude to cholesterol. The quality control of plasma fibrinogen assays has taken on new importance as a consequence of this potential role as an atherosclerotic risk factor. This article reviews the performance characteristics of 40,000 fibrinogen assays comprising the College of American Pathologists Proficiency Testing Program from 1988 through 1991. Instrument and reagent variables both play roles in the poor interlaboratory reproducibility documented by this study...
January 1993: Archives of Pathology & Laboratory Medicine
G Schmer, L Rastelli, M L Newman, M B Dennis, J S Holcenberg
A definition and a review is given for the bioartificial organ. In addition new developments are reported with the successful lyophilization of enzyme filled RCG with cryoprotective polyethylene glycol (PEG). The successful use of an enzyme reactor consisting of crosslinked fibrin with asparaginase covalently attached is reported in sheep. The small organ (0.4 m2) removes 70% of the animal's asparagine in 6 hours. No enzyme leakage down to 10(-5) units per ml. plasma could be found. The highly preserved substrate affinity of insolubilized asparaginase as well as its high activity and stability when bound to fibrin are additional outstanding features of this system...
March 1981: International Journal of Artificial Organs
K M Brinkhous, W A Fricke, M S Read
The three main probes for functional vWF activity--ristocetin, botrocetin, and the PAggF test--and similarities and differences in their elicited vWF activities have been reviewed. Emphasis has been placed on the technologies dependent on these probes, with a brief description of a series of relatively simple and sensitive tests developed in this laboratory. These tests include the development of the PAF test for vWF in certain animal plasmas; the development and use of fixed lyophilized platelets that retain receptor activity for vWF; the purification of botrocetin (venom coagglutinin) freed of thrombinlike enzymes and its use in vWF assays; the development of macroscopic platelet aggregation tests for screening and assay of vWF; and the application of the macroscopic test for rapid screening and quantitation of human plasmas for acquired inhibitors of vWF utilizing each of the three probes...
October 1985: Seminars in Thrombosis and Hemostasis
T Mandalaki
A short review is given on several aspects of the management of haemophilia in Greece. A total number of 429 patients with congenital haemorrhagic disorders has been registered. The incidence of F. VIII deficiency is 85.9% and that of F. IX 12.9%. Information concerning distribution throughout the country, age, social standard, financial position and education is given too. Haemophiliacs are systematically treated by Athens specialized Haemophilia Treatment Centres. The most widely therapeutic material still used, is fresh frozen plasma...
June 30, 1976: Thrombosis and Haemostasis
J Ranque
A global review of the porblem of malaria accidentally transmitted by blood transfusion is reported in France during these ten last years. Biological and epidemiological studies of malariae are recorded. Among the factors involved in the transmission of malariae by blood transfuction, the persistence of the parasites in the donors is very important. It is often longer than usual in the subjects who have lived in endemic malarious areas for many years or are always travelling in these countries, because they are partly protected by their acquired immunity and may be carriers of asymptomatic infection...
June 1976: Revue Française de Transfusion et Immuno-hématologie
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"