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https://www.readbyqxmd.com/read/28938384/-iatrogenic-segmental-defect-how-i-debride-high-energy-open-tibial-fractures
#1
Brendan R Southam, Michael T Archdeacon
High-energy, open tibial shaft fractures may result in significant comminution, bone loss, and soft tissue injuries. Early, thorough debridement of all nonviable tissue is of critical importance in treating these fractures as an inadequate initial debridement increases the risk of infection and nonunion. Large iatrogenic bone and soft tissue defects can result from debridement and will require subsequent reconstruction by both orthopaedic and plastic surgeons. Although a variety of approaches exist to address these reconstructions, successful management of bone defects remains a considerable challenge...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938103/let-s-talk-about-sex-a-qualitative-study-exploring-the-experiences-of-hiv-nurses-when-discussing-sexual-risk-behaviours-with-hiv-positive-men-who-have-sex-with-men
#2
S de Munnik, C den Daas, H S M Ammerlaan, G Kok, M S Raethke, S C J M Vervoort
BACKGROUND: Despite prevention efforts, the incidence of sexually transmitted infection among HIV-positive men who have sex with men remains high, which is indicative of unchanged sexual risk behaviour. Discussing sexual risk behaviour has been shown to help prevent sexually transmitted infections among HIV-positive men who have sex with men. OBJECTIVES: The aim of this study was to identify factors that influence whether - and how - specialised HIV nurses discuss sexual risk behaviour with HIV-positive men who have sex with men...
September 6, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28937705/interventions-for-treating-genital-chlamydia-trachomatis-infection-in-pregnancy
#3
REVIEW
Catherine Cluver, Natalia Novikova, David Oa Eriksson, Kevin Bengtsson, Göran K Lingman
BACKGROUND: Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour, low birthweight, preterm rupture of membranes, increased perinatal mortality, postpartum endometritis, chlamydial conjunctivitis and C.trachomatis pneumonia.This review supersedes a previous review on this topic. OBJECTIVES: To establish the most efficacious and best-tolerated therapy for treatment of genital chlamydial infection in preventing maternal infection and adverse neonatal outcomes...
September 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28936949/-clinical-practice-guidelines-of-hap-vap-in-2016-the-updates
#4
Meizhu Lu, Yan Kang
Hospital acquired pneumonia (HAP) and ventilatorassociated pneumonia (VAP) are common hospital-acquired infections with higher mortality, longer hospital stay and more hospitalization expenses. With the latest research results and evidence-based guideline methodology, Infectious Diseases Society of America (IDSA) and American Thoracic Society (ATS) have collaborated to create updated guidelines for the diagnosis and treatment of HAP and VAP in 2016. It is worth critically reading and thinking that most recommendations are supported by low-quality or very-low quality evidence and some strong recommendations is different from the actual clinical work in China...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28935430/-health-care-needs-and-barriers-in-seeking-medical-care-for-global-health-and-sexual-and-reproductive-health-among-students-from-f%C3%A3-lix-houphou%C3%A3-t-boigny-university-abidjan-c%C3%A3-te-d-ivoire
#5
M Inghels, P A Coffie, J Larmarange
BACKGROUND: In Ivory Coast, little is known about health needs and health access barriers among young people. The aim of this study was to describe health provision, health needs and barriers when seeking medical care, with an emphasis on sexual and reproductive health, and the acceptability of a medical examination for students attending their first year at the Houphouët-Boigny University, Abidjan, Ivory Coast. METHODS: We conducted a representative cross-sectional study among second year students who were selected by two-stage equiprobable random sampling...
September 18, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28935221/thermal-stability-of-mafenide-and-amphotericin-b-topical-solution
#6
Julie A Rizzo, Angela K Martini, Kaitlin A Pruskowski, Matthew P Rowan, Krista L Niece, Kevin S Akers
OBJECTIVE: Fungal infections remain a major cause of mortality in the burned population. Mafenide acetate/amphotericin B solution (SMAT) has been used topically for prophylaxis and treatment of these infections. Current manufacturer guidelines only guarantee the stability of mafenide solution and amphotericin B at room temperature. Additionally, the recommended maximum storage time for mafenide solution is 48h, leading to significant financial and material loss when unused solutions are discarded...
September 18, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28935004/intestinal-parasites-and-anthelmintic-treatments-in-a-laboratory-colony-of-wild-caught-african-pouched-rats-cricetomys-ansorgei
#7
Cassandra O Cullin, Matthew S Sellers, Erin R Rogers, Kathleen E Scott, Danielle N Lee, Alexander G Ophir, Todd A Jackson
African giant pouched rats (Cricetomys spp.) are large rodents native to subSaharan Africa. Wild-caught pouched rats identified as Cricetomys ansorgei (n = 49) were imported from Tanzania. A survey of gastrointestinal parasitism by fecal flotation revealed the presence of multiple parasites, including Nippostrongylus spp., Heterakis spp., Trichuris spp., Hymenolepis spp., Raillietina spp., and Eimeria spp. Oral self-administered fenbendazole (150 ppm), topical moxidectin (2 mg/kg), pyrantel pamoate (15 mg/kg), piperazine (100 mg/kg daily), and injectable ivermectin (0...
October 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28931063/plant-flavones-enhance-antimicrobial-activity-of-respiratory-epithelial-cell-secretions-against-pseudomonas-aeruginosa
#8
Benjamin M Hariri, Derek B McMahon, Bei Chen, Nithin D Adappa, James N Palmer, David W Kennedy, Robert J Lee
Flavones are a class of natural plant secondary metabolites that have anti-inflammatory and anti-bacterial effects. Some flavones also activate the T2R14 bitter taste receptor, which is expressed in motile cilia of the sinonasal epithelium and activates innate immune nitric oxide (NO) production. Flavones may thus be potential therapeutics for respiratory infections. Our objective was to examine the anti-microbial effects of flavones on the common sinonasal pathogens Candida albicans, Staphylococcus aureus, and Pseudomonas aeruginosa, evaluating both planktonic and biofilm growth...
2017: PloS One
https://www.readbyqxmd.com/read/28925928/subtenon-amikacin-injection-for-the-treatment-of-nocardia-asteroides-orbital-cellulitis-in-a-patient-with-a-history-of-scleral-buckling
#9
Zeynep Gursel Ozkurt, Hakan Demirci
PURPOSE: To evaluate the use of subtenon amikacin injection for the treatment of Nocardia asteroides orbital cellulitis in a patient with a history of scleral buckle surgery. METHODS: Case report. RESULTS: A 79-year-old diabetic woman presented with an 8-month history of diplopia, discharge, and swelling around her left eye. She had a scleral buckle surgery in this eye about 15 years ago. Examination of the left eye showed a visual acuity of 20/80, swollen and ptotic upper eyelid, chemotic conjunctiva, and limited extraocular motility...
October 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28925912/epidemiologic-features-of-invasive-group-a-streptococcus-infection-in-a-rural-hospital-6-year-retrospective-report-and-literature-review
#10
Kassandra Loewen, Natalie Bocking, Cai-Lei Matsumoto, Mike Kirlew, Len Kelly
INTRODUCTION: High rates of invasive group A Streptococcus disease were suspected by clinicians in northwestern Ontario. Patients with sepsis were being encountered with bacteremia positive for group A Streptococcus. This study was designed to assess the incidence of invasive group A Streptococcus infection in the region and provide best-practice treatment information. METHODS: We performed a retrospective chart review at the Sioux Lookout Meno Ya Win Health Centre (SLMHC) from 2009 to 2014 to examine rates of infection due to invasive group A Streptococcus and outcomes...
2017: Canadian Journal of Rural Medicine
https://www.readbyqxmd.com/read/28925576/is-there-an-increased-risk-of-cervical-neoplasia-in-atopic-dermatitis-patients-treated-with-oral-immunosuppressive-drugs
#11
F M Garritsen, R H M Verheijen, C G Gerestein, A D van Zuilen, J A F Oosterhaven, M van Dijk, C A F Bruijnzeel-Koomen, M L Schuttelaar, M S de Bruin-Weller
BACKGROUND: Oral immunosuppressive drugs are frequently prescribed in young women with atopic dermatitis (AD). Immunocompromised patients may have a higher risk of developing high risk HPV infections, CIN and cervical carcinoma. Most literature on patients using oral immunosuppressive drugs is available in organ transplant patients. Literature on the risk of developing cervical carcinoma in AD patients treated with oral immunosuppressive drugs is lacking. At this moment there is no clear guideline/consensus on this topic, but in daily practice, questions arise concerning whether this risk is increased and whether more intensive screening in women using immunosuppressive drugs should take place...
September 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28925548/a-bifunctional-catalase-peroxidase-makatg1-contributes-to-virulence-of-metarhizium-acridum-by-overcoming-oxidative-stress-on-the-host-insect-cuticle
#12
Guohong Li, Anni Fan, Guoxiong Peng, Nemat O Keyhani, Jiankang Xin, Yueqing Cao, Yuxian Xia
Microbial pathogens are exposed to damaging reactive oxygen species (ROS) produced from a variety of sources including chemical reactions due to exposure to stress (UV, heat) or by hosts as a defense response. Here we demonstrate that a bifunctional catalase-peroxidase, MakatG1, in the locust-specific fungal pathogen, Metarhizium acridum, functions as a ROS detoxification mechanism during host cuticle penetration. MakatG1 expression was highly induced during on-cuticle appressoria development as compared to vegetative (mycelia) growth or during in vivo growth in the insect hemocoel...
September 19, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28924436/pseudomonas-scleritis-following-pterygium-excision
#13
Winai Chaidaroon, Sumet Supalaset
PURPOSE: The aim of this case report was to describe a patient who presented with Pseudomonas scleritis after pterygium excision. The study was conducted at the Department of Ophthalmology, Faculty of Medicine, Chiang Mai University in Chiang Mai, Thailand. METHODS: The record of a patient who was diagnosed as Pseudomonas scleritis after pterygium excision was retrospectively reviewed for history, clinical characteristics, laboratory findings, treatments, and outcomes...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28923039/a-pilot-single-centre-double-blind-placebo-controlled-randomized-parallel-study-of-calmagen%C3%A2-dermaceutical-cream-and-lotion-for-the-topical-treatment-of-tinea-and-onychomycosis
#14
Manoj Parekh, Girisha Ramaiah, Prachi Pashilkar, Ranjani Ramanujam, Peter Johnston, Leodevico L Ilag
BACKGROUND: Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therapies. The study aimed to establish the fungicidal, efficacy and safety profile of Calmagen® dermaceutical cream and lotion containing AMYCOT® as a topical treatment in patients with severe to very severe presentations of fungal skin (tinea) and nail infections (onychomycosis)...
September 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28922727/the-relevance-of-gastric-cancer-biomarkers-in-prognosis-and-pre-and-post-chemotherapy-in-clinical-practice
#15
REVIEW
Muhammad Abbas, Murad Habib, Muhammad Naveed, Kumaragurubaran Karthik, Kuldeep Dhama, Meiqi Shi, Chen Dingding
Gastric cancer (GC) is one among the major cancer types, causing human deaths and present noticeable heterogeneity. The incidences and mortality rates are higher in males in comparison to females with a male to female ratio of 2.3:1. A lot of studies have revealed out the molecular basis, pathogenesis, invasion and metastasis related findings of gastric stomach cancer. Present review encompasses the salient information on various biomarkers for the early diagnosis, treatment and prognosis of gastric cancer elaborate the clinical importance of serum tumor markers in patients with this cancer as well as checking the growths, together with epigenetic changes and genetic polymorphisms...
September 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28922449/needle-syringe-programmes-and-opioid-substitution-therapy-for-preventing-hepatitis-c-transmission-in-people-who-inject-drugs
#16
REVIEW
Lucy Platt, Silvia Minozzi, Jennifer Reed, Peter Vickerman, Holly Hagan, Clare French, Ashly Jordan, Louisa Degenhardt, Vivian Hope, Sharon Hutchinson, Lisa Maher, Norah Palmateer, Avril Taylor, Julie Bruneau, Matthew Hickman
BACKGROUND: Needle syringe programmes and opioid substitution therapy for preventing hepatitis C transmission in people who inject drugsNeedle syringe programmes (NSP) and opioid substitution therapy (OST) are the primary interventions to reduce hepatitis C (HCV) transmission in people who inject drugs. There is good evidence for the effectiveness of NSP and OST in reducing injecting risk behaviour and increasing evidence for the effectiveness of OST and NSP in reducing HIV acquisition risk, but the evidence on the effectiveness of NSP and OST for preventing HCV acquisition is weak...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922207/sweet-sixteen-the-prospective-clinical-trials-of-john-l-cameron-md-the-clinician-scientist-from-alternate-allocation-to-randomized-controlled-trials
#17
Charles J Yeo
: The era of randomized controlled trials was ushered in by the British epidemiologist-statistician Austin Bradford Hill, with his work on the use of streptomycin in patients with tuberculosis. John L. Cameron, can be linked to 16 prospective clinical trials over his career thus far, starting with alternate-allocation trials and transitioning to prospective, randomized, placebo-controlled trials. These trials studied various topics in surgery-from pancreatitis to surgical site infections, to drain trials, a trial in Crohn disease and multiple trials in pancreatic surgery and cancer...
September 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28920784/treatment-success-in-three-andean-bears-tremarctos-ornatus-with-alopecia-syndrome-using-oclacitinib-maleate-apoquel%C3%A2
#18
Gabby J Drake, Tim Nuttall, Javier López, William Magnone, Antoine Leclerc, Romain Potier, Alexis Lécu, Maëlle Guézénec, Lydia Kolter, Amélie Nicolau, Karin Lemberger, Didier Pin, Sallie B Cosgrove
Andean bear (Tremarctos ornatus) alopecia syndrome (ABAS) commonly affects captive bears, particularly sexually mature females. ABAS is characterized by bilaterally symmetrical predominantly flank alopecia with or without profound pruritus and secondary bacterial and Malassezia infections. There is no effective treatment and severely affected bears have been euthanized. This paper describes the successful management of ABAS in three female Andean bears. Skin biopsies and cytology revealed a mixed dermal inflammatory infiltrate, alopecia, hyperkeratosis, and Malassezia dermatitis...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28918954/contemporary-management-of-vesicoureteral-reflux
#19
REVIEW
Perviz Hajiyev, Berk Burgu
CONTEXT: Vesicoureteral reflux (VUR) remains the most interesting topic of pediatric urology due to the dynamic nature of recent controversial publications. Starting from the need for a diagnosis to the necessity and effectiveness of treatment in preventing scars, VUR remains in the mist. Although recent strong evidence helped as fog lights in this blurriness, more data are required for achieving crystal clearance. This article aims to summarize and discuss the current state of the evidence regarding VUR management...
September 11, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28915775/wound-healing-and-anti-inflammatory-effects-of-topical-hyaluronic-acid-injection-in-surgical-site-infection-caused-by-staphylococcus-aureus
#20
Jin Hyung Park, Eon Ju Park, Hyung Suk Yi
Surgical-site infection (SSI) is a common postoperative complication, primarily caused by Staphylococcus aureus. S aureus produces hyaluronidase which degrades hyaluronic acid (HA). HA prevents bacterial proliferation and has anti-inflammatory effects to promote wound healing. We evaluated the effect of HA injection with systemic antibiotics for prevention and treatment of SSIs caused by S aureus. An open wound was created on the dorsum of 40 rats. The wound bed was sutured with S aureus inoculated thread. The test group was injected with HA (HA group), and the control group received a subcutaneous injection of normal saline (NS group)...
September 2017: International Journal of Lower Extremity Wounds
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