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https://www.readbyqxmd.com/read/28738654/development-of-a-sensitive-and-quantitative-uhplc-ms-ms-method-to-study-the-whole-body-uptake-of-pharmaceuticals-in-zebrafish
#1
Stanislav Kislyuk, Jerome Kroonen, Erwin Adams, Patrick Augustijns, Peter de Witte, Deirdre Cabooter
An analytical procedure to measure the whole-body uptake of pharmaceuticals in zebrafish has been developed using state-of-the-art methodologies. A sample preparation procedure for 9 pharmaceuticals displaying a variety in physicochemical properties was developed using 10-day old zebrafish (TG898). For an efficient homogenization of the samples and subsequent recovery of the compounds of interest, different amounts of organic solvents in combination with acidic modifiers were added to zebrafish samples. Samples were subsequently processed using a powerful bath sonicator and centrifuged...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738644/biosensor-for-the-characterisation-of-hmao-b-inhibitors-and-the-quantification-of-selegiline
#2
Maximilian Aigner, Patricia Preissegger, Kurt Kalcher, Eda Mehmeti, Peter Macheroux, Dale Edmondson, Astrid Ortner
A novel human monoamine oxidase B (hMAO B) based biosensor for inhibitory measurements was developed. It allows both the characterisation of the type of enzyme inhibition and the sensitive and simple determination of inhibitors like selegiline hydrochloride. The sensor consists of a screen printed carbon working electrode modified with 20% manganese dioxide (MnO2) and the enzyme hMAO B, which was immobilised on the electrode via a dialysis membrane (regenerated cellulose, molecular weight cut-off 14000). Inhibition of hMAO B is evaluated by adding different concentrations of the inhibitor selegiline hydrochloride to the enzyme and applying a defined amount of the hMAO B substrate phenylethylamine (PEA)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738611/a-novel-electrochemical-sensor-based-on-wo3-nanorods-decorated-poly-sodium-4-styrenesulfonate-functionalized-graphene-nanocomposite-modified-electrode-for-detecting-of-puerarin
#3
Shasha Jing, Huijun Zheng, Li Zhao, Lingbo Qu, Lanlan Yu
An electrochemical sensing platform was fabricated based on composition of poly(sodium 4-styrenesulfonate) (PSS), graphene (GN) and WO3 nanorods on glassy carbon electrode (GCE). The PSS-GN/WO3 nanocomposite significantly increased the oxidative activity of puerarin due to the individual merit and mutual effect of PSS-GN and WO3 nanorods which improved the performance of the electrochemical sensor with high sensitivity. Cyclic voltammetry (CV) and linear sweep voltammetry (LSV) measurements were used for the detection of puerarin...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738575/analytical-methodology-for-the-electro-catalytic-determination-of-estradiol-and-progesterone-based-on-graphene-quantum-dots-and-poly-sulfosalicylic-acid-co-modified-electrode
#4
Majid Arvand, Shiva Hemmati
The goal of this study was to develop an electroanalytical method for the simultaneous determination of steroid hormones for the first time. The key factor in the electrochemical methods is the choice of suitable electrode materials. For this purpose, graphene quantum dots (GQDs) doped poly(sulfosalicylic acid) (PSSA) was immobilized on a glassy carbon electrode (GCE). Apart from exhibition strong and stable electrocatalytic response towards estradiol (E2) and progesterone (P4), the proposed sensor was able to distinguish two hormone's oxidation peaks clearly...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738560/novel-metal-nanoparticle-enhanced-fluorescence-for-determination-of-trace-amounts-of-fluoroquinolone-in-aqueous-solutions
#5
Sheng-Nan Yin, Ting Yao, Tun-Hua Wu, Yong Zhang, Ping Wang
Metal-enhanced fluorescence of fluoroquinolones (FQs) was first observed in aqueous solutions. In addition, a new type of silver nanoparticles (AgNP) was synthesized with simple and easy synthetic processes and environmentally friendly compounds. The effects of different concentrations of AgNPs on the fluorescence behaviours of ciprofloxacin (CIP), enrofloxacin (ENR) and lomefloxacin (LMF) in aqueous solutions were investigated, respectively. The experimental results demonstrated that the fluorescence peak shapes and the locations of the features in the excitation and emission spectra for each FQ that was mixed with AgNPs were almost the same as those of the standard FQs...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738516/one-pot-synthesis-of-three-dimensional-mn3o4-microcubes-for-high-level-sensitive-detection-of-head-and-neck-cancer-drug-nimorazole
#6
Rajaji Umamaheswari, Muthumariappan Akilarasan, Shen-Ming Chen, Yi-Hui Cheng, Veerappan Mani, Sakthivel Kogularasu, Fahad M A Al-Hemaid, M Ajmal Ali, Xiaoheng Liu
We described a three-dimensional Mn3O4 microcubes (3D-Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D-Mn3O4 MCs possess large active area and high conductivity, and 3D-Mn3O4 MCs film modified screen-printed carbon electrode (3D-Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0...
July 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28738385/pharmacological-and-nonpharmacological-interventions-to-arrest-neuroprogression-in-psychiatric-disorders
#7
Fotini Boufidou, Angelos Halaris
The concept of neuroprogression describes the progressive course of the disorder and stresses the progressive, recurrent, and chronic course of the disease entity under consideration. It subsumes clinical manifestations of the disease process and may also entail morphological, biochemical, neurochemical, immunological, physiological, and genetic aspects that contribute to the progressive course of the disease in question. In an attempt to identify the appropriate agent or method that could arrest neuroprogression in psychiatric patients, we conducted an evaluation of the use of anti-inflammatory drugs under the perspective of current pharmacological and neurophysiological data...
July 24, 2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28738204/the-fate-of-sotalol-in-aqueous-chlorination-kinetics-mechanisms-and-ecotoxicity-assessment
#8
Wan Nor Adira Wan Khalit, Kheng Soo Tay
Unmetabolized pharmaceuticals often enter the water treatment plants and exposed to various treatment processes. Among these water treatment processes, disinfection is a process which involves the application of chemical oxidation to remove pathogen. Untreated pharmaceuticals from primary and secondary treatment have the potential to be exposed to the chemical oxidation process during disinfection. This study investigated the kinetics and mechanism of the degradation of sotalol during chlorination process. Chlorination with hypochlorous acid (HOCl) as main reactive oxidant has been known as one of the most commonly used disinfection methods...
July 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28738178/corrigendum-to-a-glucose-targeted-mixed-micellar-formulation-outperforms-genexol-in-breast-cancer-cells-euro-j-pharmaceut-biopharmaceut-114-2017-305-316
#9
Marcela A Moretton, Ezequiel Bernabeu, Estefanía Grotz, Lorena Gonzalez, Marcela Zubillaga, Diego A Chiappetta
No abstract text is available yet for this article.
July 21, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28737993/the-effect-of-formulary-restrictions-on-patient-and-payer-outcomes-a-systematic-literature-review
#10
Yujin Park, Syed Raza, Aneesh George, Rumjhum Agrawal, John Ko
BACKGROUND: Formulary restrictions are implemented to reduce pharmacy costs and ensure appropriate use of pharmaceutical products. As adoption of formulary restrictions increases with rising pharmacy costs, there is a need to better understand the potential effect of formulary restrictions on patient and payer outcomes. OBJECTIVE: To conduct a systematic literature review that assesses the effect of formulary restrictions on the following outcomes: medication adherence, clinical outcomes, treatment satisfaction, drug utilization, health care resource utilization, and economic outcomes...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737986/real-world-adherence-and-persistence-to-oral-disease-modifying-therapies-in-multiple-sclerosis-patients-over-1-year
#11
Kristen M Johnson, Huanxue Zhou, Feng Lin, John J Ko, Vivian Herrera
BACKGROUND: Disease-modifying therapies (DMTs) are indicated to reduce relapse rates and slow disease progression for relapsing-remitting multiple sclerosis (MS) patients when taken as prescribed. Nonadherence or non-persistence in the real-world setting can lead to greater risk for negative clinical outcomes. Although previous research has demonstrated greater adherence and persistence to oral DMTs compared with injectable DMTs, comparisons among oral DMTs are lacking. OBJECTIVE: To compare adherence, persistence, and time to discontinuation among MS patients newly prescribed the oral DMTs fingolimod, dimethyl fumarate, or teriflunomide...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737935/the-current-state-of-peptide-drug-discovery-back-to-the-future
#12
Antoine Henninot, James C Collins, John M Nuss
Over the last decade, peptide drug discovery has experienced a revival of interest and scientific momentum, as the pharmaceutical industry has come to appreciate the role that peptide therapeutics can play in addressing unmet medical needs, and how this class of compounds can be an excellent complement or even preferable alternative to small molecule and biological therapeutics. In this perspective we give a concise description of the recent progress in peptide drug discovery in a holistic manner, highlighting enabling technological advances affecting nearly every aspect of this field: from lead discovery, to synthesis and optimization, to peptide drug delivery...
July 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28737911/platform-for-unified-molecular-analysis-puma
#13
Mariana González-Medina, Jose Luis Medina-Franco
We introduce a free platform for chemoinformatic-based diversity analysis and visualization of chemical space of user supplied data sets. Platform for Unified Molecular Analysis (PUMA) integrates metrics used to characterize compound databases including visualization of chemical space, scaffold content, and analysis of chemical diversity. The user's input is a file with SMILES, database names, and compound IDs. PUMA computes molecular properties of pharmaceutical relevance, Murcko scaffolds, and diversity analysis...
July 24, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28737444/evolving-patterns-in-a-collaboration-network-of-global-r-d-on-monoclonal-antibodies
#14
Xiangjun Kong, Jian-Bo Wan, Hao Hu, Shibing Su, Yuanjia Hu
We investigated the evolution process of collaborative inter-organizational network of the research and development (R&D) on monoclonal antibody (mAb) over the past 30 years. The annual detection of the collaboration network provides dynamics on network structures and relationship changes among different organizations. Our research showed continuous growth of the network's scale and complexity due to the constant entry of new organizations and the forging of new partnering relationships. The evolving topological features reveal a core-periphery structure that became clearer over time and an increasing heterogeneity within the collaborative mAb R&D network...
July 24, 2017: MAbs
https://www.readbyqxmd.com/read/28737409/low-buffer-capacity-and-alternating-motility-along-the-human-gastrointestinal-tract-implications-for-in-vivo-dissolution-and-absorption-of-ionizable-drugs
#15
Bart Hens, Yasuhiro Tsume, Marival Bermejo, Paulo Paixao, Mark Koenigsknecht, Jason R Baker, William L Hasler, R Lionberger, Jianghong Fan, Joseph Dickens, Kerby A Shedden, Bo Wen, Jeffrey Wysocki, Raimar Löbenberg, Allen Lee, Ann F Fioritto, Gregory E Amidon, Alex Yu, Gail Benninghoff, Niloufar Salehi, Arjang Talattof, Duxin Sun, Gordon L Amidon
In this study, we determined the pH and buffer capacity of human gastrointestinal (GI) fluids (aspirated from the stomach, duodenum, proximal jejunum and mid/distal jejunum) as a function of time, from 37 healthy subjects after oral administration of an 800 mg immediate-release tablet of ibuprofen (reference listed drug; RLD) under typical prescribed bioequivalence (BE) study protocol conditions in both fasted and fed state (simulated by ingestion of a liquid meal). Simultaneously, motility was continuously monitored using water-perfused manometry...
July 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28737406/preclinical-effect-of-absorption-modifying-excipients-on-rat-intestinal-transport-of-five-model-compounds-and-the-intestinal-barrier-marker-51-cr-edta
#16
David Dahlgren, Carl Roos, Anders Lundqvist, Peter Langguth, Christer Tannergren, Markus Sjöblom, E Sjögren, H Lennernas
There is a renewed interest from the pharmaceutical field to develop oral formulations of compounds such as peptides, oligonucleotides, and polar drugs. However, these often suffer from insufficient absorption across the intestinal mucosal barrier. One approach to circumvent this problem is the use of absorption modifying excipient(s) (AME). This study determined the absorption enhancing effect of four AMEs (sodium dodecyl sulfate, caprate, chitosan, N-acetylcysteine) on five model compounds in a rat jejunal perfusion model...
July 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28737403/validation-of-dissolution-testing-with-biorelevant-media-an-orbito-study
#17
James Mann, Jennifer B Dressman, Karin Rosenblatt, Lee Ashworth, Uwe Muenster, Kerstin Frank, Paul Hutchins, James Williams, Lukas Klumpp, Kristina Wielockx, Philippe Berben, Patrick Augustijns, Rene Holm, Michael Hofmann, Sanjaykumar Patel, Stefania Beato, Krista Ojala, Irena Tomaszewska, Jean-Luc Bruel, James Butler
BACKGROUND: Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to gauge the reproducibility of results obtained with these methods. PURPOSE: The aim of this study was to determine the inter-laboratory reproducibility of biorelevant dissolution testing, using the paddle apparatus (USP 2)...
July 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28737242/customers-perceptions-of-and-satisfaction-with-medicine-retail-outlet-services-in-addis-ababa-ethiopia-a-cross-sectional-study
#18
Dawit T Gebregeorgise, Tofik A Mohammed, Zebiba S Redi, Sofia Kälvemark Sporrong
OBJECTIVES: The aim of this study was to assess customers' perceptions of and satisfaction with MRO services in Addis Ababa and to explore factors associated with their satisfaction and reasons for visits. METHODS: A cross-sectional survey was conducted among customers selected from 28 MROs in Addis Ababa, using multi-stage sampling techniques. Simple descriptive statistics and multivariable logistic regression at 95% confidence interval were used for the analysis...
July 24, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28737220/current-state-of-pharmacovigilance-in-the-arab-and-eastern-mediterranean-region-results-of-a-2015-survey
#19
Danya M Qato
OBJECTIVES: This study describes the current state of pharmacovigilance systems in Arab and Eastern Mediterranean countries. METHODS: A descriptive cross-sectional study was conducted between May and September 2015. Data were gathered from a standardized online survey sent to pharmacovigilance leadership identified as the official national contact for the WHO Programme for International Drug Monitoring. In countries with no specified pharmacovigilance programme or leadership, Ministry of Health officers responsible for drug safety policies were invited to participate in the survey...
July 24, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28737187/recent-advances-in-asymmetric-total-synthesis-of-prostaglandins
#20
REVIEW
Haihui Peng, Fen-Er Chen
Prostaglandins (PGs) are a series of hormone-like chemical messengers and play a critical role in regulating physiological activity. The diversified therapeutic activities and complex molecular architectures of PGs have attracted special attention, and huge progress has been made in asymmetric total synthesis and discovery of pharmaceutically useful drug candidates. In the last 10 years, several powerful syntheses have emerged as new solutions to the problem of building PGs and represent major breakthroughs in this area...
July 24, 2017: Organic & Biomolecular Chemistry
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