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https://www.readbyqxmd.com/read/28915986/exploration-of-gender-norms-and-socialization-among-early-adolescents-the-use-of-qualitative-methods-for-the-global-early-adolescent-study
#1
REVIEW
Kristin Mmari, Robert W Blum, Rebkha Atnafou, Elisa Chilet, Sara de Meyer, Omaima El-Gibaly, Sharmista Basu, Bamidele Bello, Beatrice Maina, Xiayun Zuo
PURPOSE: The Global Early Adolescent Study (GEAS) was launched in 2014 with the primary goal of understanding the factors in early adolescence that predispose young people to subsequent sexual risks, and conversely, those that promote healthy sexuality across different cultural contexts. The present article describes the methodology that was used for the first phase of GEAS, which consisted of conducting qualitative research to understand the gendered transitions into adolescence and the role that gender norms play within the key relationships of adolescents...
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28915659/data-driven-analysis-of-immune-infiltrate-in-a-large-cohort-of-breast-cancer-and-its-association-with-disease-progression-er-activity-and-genomic-complexity
#2
Ruth Dannenfelser, Marianne Nome, Andliena Tahiri, Josie Ursini-Siegel, Hans Kristian Moen Vollan, Vilde D Haakensen, Åslaug Helland, Bjørn Naume, Carlos Caldas, Anne-Lise Børresen-Dale, Vessela N Kristensen, Olga G Troyanskaya
The tumor microenvironment is now widely recognized for its role in tumor progression, treatment response, and clinical outcome. The intratumoral immunological landscape, in particular, has been shown to exert both pro-tumorigenic and anti-tumorigenic effects. Identifying immunologically active or silent tumors may be an important indication for administration of therapy, and detecting early infiltration patterns may uncover factors that contribute to early risk. Thus far, direct detailed studies of the cell composition of tumor infiltration have been limited; with some studies giving approximate quantifications using immunohistochemistry and other small studies obtaining detailed measurements by isolating cells from excised tumors and sorting them using flow cytometry...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915331/dual-specificity-phosphatase-5-substrate-interaction-a-mechanistic-perspective
#3
Raman G Kutty, Marat R Talipov, Robert D Bongard, Rachel A Jones Lipinski, Noreena L Sweeney, Daniel S Sem, Rajendra Rathore, Ramani Ramchandran
The mammalian genome contains approximately 200 phosphatases that are responsible for catalytically removing phosphate groups from proteins. In this review, we discuss dual specificity phosphatase 5 (DUSP5). DUSP5 belongs to the dual specificity phosphatase (DUSP) family, so named after the family members' abilities to remove phosphate groups from serine/threonine and tyrosine residues. We provide a comparison of DUSP5's structure to other DUSPs and, using molecular modeling studies, provide an explanation for DUSP5's mechanistic interaction and specificity toward phospho-extracellular regulated kinase, its only known substrate...
September 12, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28915298/the-effect-of-stimulus-variability-on-learning-and-generalization-of-reading-in-a-novel-script
#4
Jasmeen Adwan-Mansour, Tali Bitan
Purpose: The benefit of stimulus variability for generalization of acquired skills and knowledge has been shown in motor, perceptual, and language learning but has rarely been studied in reading. We studied the effect of variable training in a novel language on reading trained and untrained words. Method: Sixty typical adults received 2 sessions of training in reading an artificial script. Participants were assigned to 1 of 3 groups: a variable training group practicing a large set of 24 words, and 2 nonvariable training groups practicing a smaller set of 12 words, with twice the number of repetitions per word...
September 15, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28912113/mobile-augmented-reality-as-a-feature-for-self-oriented-blended-learning-in-medicine-randomized-controlled-trial
#5
Christoph Noll, Ute von Jan, Ulrike Raap, Urs-Vito Albrecht
BACKGROUND: Advantages of mobile Augmented Reality (mAR) application-based learning versus textbook-based learning were already shown in a previous study. However, it was unclear whether the augmented reality (AR) component was responsible for the success of the self-developed app or whether this was attributable to the novelty of using mobile technology for learning. OBJECTIVE: The study's aim was to test the hypothesis whether there is no difference in learning success between learners who employed the mobile AR component and those who learned without it to determine possible effects of mAR...
September 14, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28904215/everyday-exotropia-learning-from-the-littlest
#6
Judy L Petrunak
BACKGROUND AND PURPOSE: Early onset exodeviations in systemically and ocularly healthy young children, diagnosed at less than 1 year of age, may be of the constant, "infantile XT" type, or early X(T) type. The onset of common childhood X(T) is not clearly known. The purpose of this lecture is to discuss theories and characteristics of early onset exodeviations, and report on our observations of infantile XT and early X(T) at Children's Eye Care in Michigan. PATIENTS AND METHODS: A retrospective review of 470 cases of childhood exodeviations (ages 6 months to 15 years) were reviewed and met inclusion criteria of no prior surgical treatment, no ocular, CNS or craniofacial disease, and no significant prematurity...
January 2017: American Orthoptic Journal
https://www.readbyqxmd.com/read/28902868/discovery-of-numerous-novel-small-genes-in-the-intergenic-regions-of-the-escherichia-coli-o157-h7-sakai-genome
#7
Sarah M Hücker, Zachary Ardern, Tatyana Goldberg, Andrea Schafferhans, Michael Bernhofer, Gisle Vestergaard, Chase W Nelson, Michael Schloter, Burkhard Rost, Siegfried Scherer, Klaus Neuhaus
In the past, short protein-coding genes were often disregarded by genome annotation pipelines. Transcriptome sequencing (RNAseq) signals outside of annotated genes have usually been interpreted to indicate either ncRNA or pervasive transcription. Therefore, in addition to the transcriptome, the translatome (RIBOseq) of the enteric pathogen Escherichia coli O157:H7 strain Sakai was determined at two optimal growth conditions and a severe stress condition combining low temperature and high osmotic pressure. All intergenic open reading frames potentially encoding a protein of ≥ 30 amino acids were investigated with regard to coverage by transcription and translation signals and their translatability expressed by the ribosomal coverage value...
2017: PloS One
https://www.readbyqxmd.com/read/28902409/binswanger-s-disease-biomarkers-in-the-inflammatory-form-of-vascular-cognitive-impairment-and-dementia
#8
REVIEW
Gary A Rosenberg
Vascular cognitive impairment and dementia (VCID) is a major public health concern because of the increased incidence of vascular disease in the aging population and the impact of vascular disease on Alzheimer's disease. VCID is a heterogeneous group of diseases for which there are no proven treatments. Biomarkers can be used to select more homogeneous populations. Small vessel disease is the most prevalent form of VCID and is the optimal form for treatment trials because there is a progressive course with characteristic pathological changes...
September 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28901705/peer-assisted-learning-and-small-group-teaching-to-improve-practice-placement-quality-and-capacity-in-dietetics
#9
Dianne P Reidlinger, Judy Lawrence, Jane E Thomas, Kevin Whelan
AIM: Peer-assisted learning (PAL) has been positively evaluated during practice placements for medical, nursing and some allied health professional students. The aim of this study was to evaluate a PAL and small-group teaching model of dietetic practice placement education implemented in the UK setting as part of a quality improvement process. METHODS: A PAL placement model was adapted from a previously published Australian model, implemented and evaluated among dietetic students at King's College London and with their practice educators...
September 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28898728/nursing-students-collaborating-to-develop-multiple-choice-exam-revision-questions-a-student-engagement-study
#10
Judy A Craft, Martin Christensen, Natasha Shaw, Shannon Bakon
BACKGROUND: Nursing students find bioscience subjects challenging. Bioscience exams pose particular concerns for these students, which may lead to students adopting a surface-approach to learning. OBJECTIVES: To promote student collective understanding of bioscience, improve their confidence for the final exam, and improve deeper understanding of bioscience. DESIGN: In order to address exam anxiety, and improve student understanding of content, this student engagement project involved nursing students collaborating in small groups to develop multiple-choice questions and answers, which became available to the entire student cohort...
September 6, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28890926/peer-assisted-history-taking-groups-a-subjective-assessment-of-their-impact-upon-medical-students-interview-skills
#11
Katharina Eva Keifenheim, Ernst Richard Petzold, Florian Junne, Rebecca Sarah Erschens, Natalie Speiser, Anne Herrmann-Werner, Stephan Zipfel, Martin Teufel
Background and Objectives: Among the clinical skills needed by all physicians, history taking is one of the most important. The teaching model for peer-assisted history-taking groups investigated in the present study consists of small-group courses in which students practice conducting medical interviews with real patients. The purpose of this pilot study was to investigate the expectations, experiences, and subjective learning progress of participants in peer-assisted history-taking groups. Methods: The 42 medical student participants completed a 4-month, peer-assisted, elective history-taking course, which both began and ended with a subjective assessment of their interview skills by way of a pseudonymized questionnaire...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28890918/evidence-for-improved-memory-from-5%C3%A2-minutes-of-immediate-post-encoding-exercise-among-women
#12
Steven B Most, Briana L Kennedy, Edgar A Petras
Memories consolidate over time, with one consequence being that what we experience after learning can influence what we remember. In these experiments, women who engaged in 5 minutes of low-impact exercise immediately after learning showed better recall for paired associations than did women who engaged in a non-exercise control activity. In experiments 1 and 2, this benefit was apparent in a direct comparison between exercise and non-exercise groups. In experiment 3, it was reflected in a weak, positive correlation between memory performance and exercise-induced change in heart rate...
2017: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/28881979/identification-of-associations-between-genotypes-and-longitudinal-phenotypes-via-temporally-constrained-group-sparse-canonical-correlation-analysis
#13
Xiaoke Hao, Chanxiu Li, Jingwen Yan, Xiaohui Yao, Shannon L Risacher, Andrew J Saykin, Li Shen, Daoqiang Zhang
Motivation: Neuroimaging genetics identifies the relationships between genetic variants (i.e., the single nucleotide polymorphisms) and brain imaging data to reveal the associations from genotypes to phenotypes. So far, most existing machine-learning approaches are widely used to detect the effective associations between genetic variants and brain imaging data at one time-point. However, those associations are based on static phenotypes and ignore the temporal dynamics of the phenotypical changes...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28879173/integrating-public-health-and-health-promotion-practice-in-the-medical-curriculum-a-self-directed-team-based-project-approach
#14
Geraldine Kershaw, Michal Grivna, Iffat Elbarazi, Souheila AliHassan, Faisal Aziz, Aysha Ibrahim Al Dhaheri
Preparing health professionals in health promotion (HP) and disease prevention is essential for improvement of population health, community HP, and better health care for individuals. The aim of this article is to describe an HP project in the form of a major self-directed project-based learning task integrated within the curriculum in the second year of the medical degree program at United Arab Emirates University. The project introduces students to public health and HP practice and develops students' literature searching, writing, presentation skills, and team work...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28877138/pain-in-children-with-developmental-disabilities-development-and-preliminary-effectiveness-of-a-pain-training-workshop-for-respite-workers
#15
Lara M Genik, C Meghan McMurtry, Lynn M Breau, Stephen P Lewis, Tamlyn Freedman-Kalchman
INTRODUCTION: Pain in children with intellectual disabilities (ID) is common and complex, yet there is no standard pain training for their secondary caregivers. OBJECTIVES: Determine perceived pain training needs/preferences of children's respite staff (Phase One) and, use this information combined with extant research and guidelines to develop and pilot a training (Phase Two). METHODS: In Phase One, 22 participants responded to questionnaires and engaged in individual interviews/focus groups about their experiences with pain in children with ID, and perceived training needs/preferences...
September 1, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28876994/encouraging-critical-clinical-thinking-cct-skills-in-first-year-veterinary-students
#16
Duncan C Ferguson, Leslie Klis McNeil, David J Schaeffe, Eric M Mills
First-year didactic course instructors at the University of Illinois College of Veterinary Medicine leverage earlier clinical rotation experiences with weekly "Clinical Correlations" exercises to provide early exposure to critical clinical thinking (CCT). This study evaluated the efficacy of individual and paired group exercises on CCT development. Before and after instruction, the Cornell Critical Thinking Test (Level Z) (CCTTZ) was administered. Based on the hypothesis that students with higher scores would coach lower-scoring colleagues during group exercises, heterogeneous groups with similar mean scores were established for the year...
2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28874195/malalignment-and-malposition-of-quadriceps-sparing-approach-in-primary-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#17
REVIEW
Fu-Zhen Yuan, Shao-Jie Wang, Zhu-Xing Zhou, Jia-Kuo Yu, Dong Jiang
BACKGROUND: Quadriceps-sparing (QS) approach is considered to be the most minimally invasive surgery for total knee arthroplasty (TKA). We perform this meta-analysis to evaluate whether malalignment and malposition are more biased towards the QS approach compared to the traditional medial parapatellar (MP) approach, which is still controversial. METHODS: According to the PRISMA guidelines, a comprehensive search was conducted in the databases of PubMed, the Cochrane library, and Embase...
September 6, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28869825/patient-learning-of-treatment-contents-in-cognitive-therapy
#18
Nicole B Gumport, Lu Dong, Jason Y Lee, Allison G Harvey
BACKGROUND AND OBJECTIVES: Research has demonstrated that both memory and learning for treatment contents are poor, and that both are associated with worse treatment outcome. The Memory Support Intervention has been shown to improve memory for treatment, but it has not yet been established if this intervention can also improve learning of treatment contents. This study was designed to document the number of times participants exhibited each of the indices of learning, to examine the indices of learning and their relationship to recall of treatment points, and to investigate the association between the indices of learning and depression outcome...
August 31, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28869475/effect-of-attention-training-in-mild-cognitive-impairment-patients-with-subcortical-vascular-changes-the-rehatt-study
#19
Leonardo Pantoni, Anna Poggesi, Stefano Diciotti, Raffaella Valenti, Stefano Orsolini, Eleonora Della Rocca, Domenico Inzitari, Mario Mascalchi, Emilia Salvadori
BACKGROUND AND OBJECTIVE: Mild cognitive impairment (MCI) patients with small vessel disease (SVD) are at high dementia risk. We tested the effects of cognitive rehabilitation in these patients using the Attention Process Training-II (APT-II) program in a single-blinded, randomized clinical trial. METHODS: Patients were randomized to APT-II or standard care and evaluated at baseline, 6, and 12 months with functional, quality of life, cognitive tests, and resting state functional MRI (rsfMRI)...
August 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28868124/neuroprotective-role-of-curcumin-on-the-hippocampus-against-the-structural-and-serological-alterations-of-streptozotocin-induced-diabetes-in-sprague-dawely-rats
#20
Nermeen Mohammed Faheem, Ahmad El Askary
OBJECTIVES: Diabetes mellitus causes impaired memory and cognitive functions. The hippocampus plays a key role in memory and learning. Curcumin attenuates diabetic nephropathy in vivo. Curcumin has shown a neurogenic effect and cognition-enhancing potential in aged rats. The aim of this study is to evaluate the possible protective role of curcumin on the histological and serological changes of the hippocampus in diabetic rats. MATERIALS AND METHODS: Forty albino rats were divided into four groups, ten rats each...
June 2017: Iranian Journal of Basic Medical Sciences
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