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https://www.readbyqxmd.com/read/29355304/computationally-assessing-the-bioactivation-of-drugs-by-n-dealkylation
#1
Na Le Dang, Tyler B Hughes, Grover Paul Miller, S Joshua Swamidass
Cytochromes P450 (CYPs) oxidize alkylated amines commonly found in drugs and other biologically active molecules, splitting them into an amine and an aldehyde. Metabolic studies usually neglect to report or investigate aldehydes, even though they can be toxic. It is assumed that they are efficiently detoxified into carboxylic acids and alcohols. Nevertheless, some aldehydes are reactive and escape detoxification pathways to cause adverse events by forming DNA and protein adducts. Herein, we modeled N-dealkylations that produce both amine and aldehyde metabolites and then predicted the reactivity of the aldehyde...
January 22, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29354296/learning-styles-and-strategies-preferences-of-iranian-medical-students-in-gross-anatomy-courses-and-their-correlations-with-gender
#2
Mohammad Ali Atlasi, Alireza Moravveji, Hossein Nikzad, Vahid Mehrabadi, Homayoun Naderian
The learning approaches can help anatomy teachers design a suitable curriculum in harmony with their students' learning styles. The research objective is to evaluate gross anatomy learning styles and strategies preferences of Iranian medical students at Kashan University of Medical Sciences (KAUMS). This cross-sectional questionnaire-based study was carried out on 237 Iranian medical students. The students answered questions on approaches to learning anatomy and expressed opinions about learning anatomy in medical curriculum...
December 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29353508/vocabulary-comprehension-and-strategies-in-name-construction-among-children-using-aided-communication
#3
Débora Deliberato, Margareta Jennische, Judith Oxley, Leila Regina d'Oliveira de Paula Nunes, Cátia Crivelenti de Figueiredo Walter, Munique Massaro, Maria Amélia Almeida, Kristine Stadskleiv, Carmen Basil, Marc Coronas, Martine Smith, Stephen von Tetzchner
Vocabulary learning reflects the language experiences of the child, both in typical and atypical development, although the vocabulary development of children who use aided communication may differ from children who use natural speech. This study compared the performance of children using aided communication with that of peers using natural speech on two measures of vocabulary knowledge: comprehension of graphic symbols and labeling of common objects. There were 92 participants not considered intellectually disabled in the aided group...
January 22, 2018: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/29351500/differential-learning-as-a-key-training-approach-to-improve-creative-and-tactical-behavior-in-soccer
#4
Sara Santos, Diogo Coutinho, Bruno Gonçalves, Wolfgang Schöllhorn, Jaime Sampaio, Nuno Leite
PURPOSE: The aim of this study was to identify the effects of a differential-learning program, embedded in small-sided games, on the creative and tactical behavior of youth soccer players. Forty players from under-13 (U13) and under-15 (U15) were allocated into control and experimental groups and were tested using a randomized pretest to posttest design using small-sided games situations. METHOD: The experimental group participated in a 5-month differential-learning program embodied in small-sided games situations, while the control group participated in a typical small-sided games training program...
January 19, 2018: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/29351132/mixed-methods-approach-to-humanistic-interprofessional-faculty-development
#5
Alice Fornari, Leanne M Tortez, Monika Lay, Bruce Hirsch, Donna Tanzi, Isabel Friedman, Alison P Ricardo, Renee Pekmezaris, William Branch
INTRODUCTION: This study evaluated the effectiveness of the Mentoring and Professionalism in Training (MAP-IT) program, a longitudinal, interprofessional faculty development curriculum designed to enhance clinicians' humanistic mentoring skills, specifically nurses and physicians. METHODS: During 2014 to 2016, two consecutive cohorts of nurses and physicians completed the MAP-IT program. Participants included 169 high potential mentors (HPMs) and 61 facilitator leaders...
January 16, 2018: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/29348208/learning-to-make-external-sensory-stimulus-predictions-using-internal-correlations-in-populations-of-neurons
#6
Audrey J Sederberg, Jason N MacLean, Stephanie E Palmer
To compensate for sensory processing delays, the visual system must make predictions to ensure timely and appropriate behaviors. Recent work has found predictive information about the stimulus in neural populations early in vision processing, starting in the retina. However, to utilize this information, cells downstream must be able to read out the predictive information from the spiking activity of retinal ganglion cells. Here we investigate whether a downstream cell could learn efficient encoding of predictive information in its inputs from the correlations in the inputs themselves, in the absence of other instructive signals...
January 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29344449/motivating-students-for-project-based-learning-for-application-of-research-methodology-skills
#7
Ranjana Tiwari, Raj Kumar Arya, Manoj Bansal
Introduction: Project-based learning (PBL) is motivational for students to learn research methodology skills. It is a way to engage and give them ownership over their own learning. Aims and Objectives: The aim of this study is to use PBL for application of research methodology skills for better learning by encouraging an all-inclusive approach in teaching and learning rather than an individualized tailored approach. Methodology: The present study was carried out for MBBS 6th- and 7th-semester students of community medicine...
December 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29341809/modified-directed-self-learning-sessions-in-physiology-with-prereading-assignments-and-pecha-kucha-talks-perceptions-of-students
#8
Reem Rachel Abraham, Sharmila Torke, James Gonsalves, Sareesh Naduvil Narayanan, M Ganesh Kamath, Jay Prakash, Kiranmai S Rai
The present study reports perceptions of first-year undergraduate medical students ( n = 120), regarding modified directed self-learning (DSL) sessions in physiology. Students were provided with prereading assignments (faculty developed PowerPoint slides containing diagrams with incomplete labeling/flowcharts with missing steps) pertaining to the DSL topic 1 wk before the scheduled small-group DSL presentations. During DSL presentation sessions, which were facilitated by teachers, a few students individually presented learning objectives in the specified topic...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29338860/learning-curve-of-image-guided-video-assisted-thoracoscopic-surgery-for-small-pulmonary-nodules-a-prospective-analysis-of-30-initial-patients
#9
Ming-Ju Hsieh, Chih-Tsung Wen, Hsin-Yueh Fang, Yu-Wen Wen, Chien-Cheng Lin, Yin-Kai Chao
OBJECTIVES: The use of image-guided video-assisted thoracoscopic surgery for simultaneous localization and removal of small solitary pulmonary nodules in a hybrid operation room using C-arm cone-beam computed tomography is gaining momentum. We sought to assess the effect of the learning curve on procedural parameters and clinical outcomes of image-guided video-assisted thoracoscopic surgery for treating patients with small solitary pulmonary nodules. METHODS: Clinical variables and treatment outcomes of the 30 initial patients with solitary pulmonary nodules who were treated with image-guided video-assisted thoracoscopic surgery at Chang Gung Memorial Hospital (Taiwan) were prospectively analyzed...
December 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29338013/dynamical-networks-of-influence-in-small-group-discussions
#10
Mehdi Moussaïd, Alejandro Noriega Campero, Abdullah Almaatouq
In many domains of life, business and management, numerous problems are addressed by small groups of individuals engaged in face-to-face discussions. While research in social psychology has a long history of studying the determinants of small group performances, the internal dynamics that govern a group discussion are not yet well understood. Here, we rely on computational methods based on network analyses and opinion dynamics to describe how individuals influence each other during a group discussion. We consider the situation in which a small group of three individuals engages in a discussion to solve an estimation task...
2018: PloS One
https://www.readbyqxmd.com/read/29331798/engaging-students-in-a-community-of-learning-renegotiating-the-learning-environment
#11
Karen A Theobald, Carol A Windsor, Elizabeth M Forster
Promoting student engagement in a student led environment can be challenging. This article reports on the process of design, implementation and evaluation of a student led learning approach in a small group tutorial environment in a three year Bachelor of Nursing program at an Australian university. The research employed three phases of data collection. The first phase explored student perceptions of learning and engagement in tutorials. The results informed the development of a web based learning resource...
December 27, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#12
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29330229/determining-the-educational-impact-of-the-introduction-of-practice-based-small-group-learning-within-an-intraprofessional-group-of-doctors
#13
Antony Sean Willman
INTRODUCTION: Practice-Based Small Group Learning (PBSGL) is a system for continuing professional development introduced into Wessex Region Defence Primary Healthcare (DPHC) as the Salisbury Plain PBSGL group in 2012. This is a mixed intraprofessional group comprising general practitioners (GPs), GP trainers, general practice specialist registrars (GPSTs) and general duties medical officers (GDMOs). METHODS: An anonymised online questionnaire and thematic analysis was undertaken to assess the educational impact of PBSGL in such a mixed-role group reflecting military general practice...
January 12, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29329288/soil-transmitted-helminth-infection-loss-of-education-and-cognitive-impairment-in-school-aged-children-a-systematic-review-and-meta-analysis
#14
Noel Pabalan, Eloisa Singian, Lani Tabangay, Hamdi Jarjanazi, Michael J Boivin, Amara E Ezeamama
BACKGROUND: Evidence of an adverse influence of soil transmitted helminth (STH) infections on cognitive function and educational loss is equivocal. Prior meta-analyses have focused on randomized controlled trials only and have not sufficiently explored the potential for disparate influence of STH infection by cognitive domain. We re-examine the hypothesis that STH infection is associated with cognitive deficit and educational loss using data from all primary epidemiologic studies published between 1992 and 2016...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29326856/using-small-case-based-learning-groups-as-a-setting-for-teaching-medical-students-how-to-provide-and-receive-peer-feedback
#15
Emily C Bird, Neil Osheroff, Cathleen C Pettepher, William B Cutrer, Robert H Carnahan
As future physicians, nearly all medical students will be required to provide face-to-face feedback. Moreover, receiving high quality feedback from multiple perspectives is particularly valuable during the pre-clerkship training period. To address these needs, we developed a straightforward, easy to implement exercise that affords students the opportunity to practice giving and receiving feedback with peers. We describe how this exercise has been tailored to fit within the case-based learning small groups of our first-year curriculum and how to enhance the activity by weaving the basic principles of quality feedback into preparation sessions...
December 2017: Medical Science Educator
https://www.readbyqxmd.com/read/29324298/calibration-of-raw-accelerometer-data-to-measure-physical-activity-a-systematic-review
#16
REVIEW
Márcio de Almeida Mendes, Inácio C M da Silva, Virgílio V Ramires, Felipe F Reichert, Rafaela C Martins, Elaine Tomasi
Most of calibration studies based on accelerometry were developed using count-based analyses. In contrast, calibration studies based on raw acceleration signals are relatively recent and their evidences are incipient. The aim of the current study was to systematically review the literature in order to summarize methodological characteristics and results from raw data calibration studies. The review was conducted up to May 2017 using four databases: PubMed, Scopus, SPORTDiscus and Web of Science. Methodological quality of the included studies was evaluated using the Landis and Koch's guidelines...
December 30, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29322935/classifying-cancer-genome-aberrations-by-their-mutually-exclusive-effects-on-transcription
#17
Jonathan B Dayton, Stephen R Piccolo
BACKGROUND: Malignant tumors are typically caused by a conglomeration of genomic aberrations-including point mutations, small insertions, small deletions, and large copy-number variations. In some cases, specific chemotherapies and targeted drug treatments are effective against tumors that harbor certain genomic aberrations. However, predictive aberrations (biomarkers) have not been identified for many tumor types and treatments. One way to address this problem is to examine the downstream, transcriptional effects of genomic aberrations and to identify characteristic patterns...
December 21, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29320519/the-effect-of-small-sided-games-with-different-levels-of-opposition-on-the-tactical-behaviour-of-young-footballers-with-different-levels-of-sport-expertise
#18
Alba Práxedes, Alberto Moreno, Alexander Gil-Arias, Fernando Claver, Fernando Del Villar
To optimize players' tactical abilities, coaches need to design training sessions with representative learning tasks, such as, small-sided games. Moreover, it is necessary to adapt the complexity of the tasks to the skill level of the athletes to maximally improve their perceptual, visual and attentive abilities. The objective of this study was to analyze the effect of two teaching programs, each utilizing modified games with varied levels of opposition, on decision-making and action execution in young players with different levels of sports expertise...
2018: PloS One
https://www.readbyqxmd.com/read/29319274/evaluating-a-co-facilitation-approach-to-service-user-and-carer-involvement-in-undergraduate-nurse-education
#19
Anne Felton, Joan Cook, Roni Anthony
Partnership working with service users and carers is an integral aspect of healthcare practice and education. Increasingly complex healthcare environments, alongside changes in higher education, have led to the development of innovative learning strategies, resulting in opportunities for service users to participate in nurse education. This article describes the planning, implementation and evaluation of a co-facilitation approach to learning, in which service users and carers worked alongside lecturers to facilitate small seminar group activities with first-year undergraduate nursing students...
January 10, 2018: Nursing Standard
https://www.readbyqxmd.com/read/29313875/memo-efficacy-durability-and-effect-of-cognitive-training-and-psychosocial-intervention-in-individuals-with-mild-cognitive-impairment
#20
Sylvie Belleville, Carol Hudon, Nathalie Bier, Catherine Brodeur, Brigitte Gilbert, Sébastien Grenier, Marie-Christine Ouellet, Chantal Viscogliosi, Serge Gauthier
BACKGROUND/OBJECTIVES: There is no consensus on the efficacy of cognitive training in persons with mild cognitive impairment (MCI) because of the paucity of well-designed randomized controlled trials. The objective was to assess the effect of memory training on the cognitive functioning of persons with MCI and its durability and to evaluate whether this effect generalizes to daily life and whether positive effects could be obtained from psychosocial intervention. DESIGN: Single-blind randomized controlled trial...
January 4, 2018: Journal of the American Geriatrics Society
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