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https://www.readbyqxmd.com/read/29444257/comparison-of-strategies-and-incidence-thresholds-for-vi-conjugate-vaccines-against-typhoid-fever-a-cost-effectiveness-modeling-study
#1
Nathan C Lo, Ribhav Gupta, Jeffrey D Stanaway, Denise O Garrett, Isaac I Bogoch, Stephen P Luby, Jason R Andrews
Background: Typhoid fever remains a major public health problem globally. While new Vi conjugate vaccines hold promise for averting disease, the optimal programmatic delivery remains unclear. We aimed to identify the strategies and associated epidemiologic conditions under which Vi conjugate vaccines would be cost-effective. Methods: We developed a dynamic, age-structured transmission and cost-effectiveness model that simulated multiple vaccination strategies with a typhoid Vi conjugate vaccine from a societal perspective...
February 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29443509/ph-responsive-microencapsulation-systems-for-the-oral-delivery-of-polyanhydride-nanoparticles
#2
Lindsey A Sharpe, Julia E Vela Ramirez, Olivia M Haddadin, Kathleen A Ross, Balaji Narasimhan, Nicholas A Peppas
Multi-compartmental polymer carriers, referred to as Polyanhydride-Releasing Oral MicroParticle Technology (PROMPT), were formed by a pH-triggered anti-solvent precipitation technique. Polyanhydride nanoparticles were encapsulated into anionic pH-responsive microparticles, allowing for nanoparticle encapsulation in acidic conditions and subsequent release in neutral pH conditions. The effects of varying the nanoparticle composition and feed ratio on the encapsulation efficiency were evaluated. Nanoparticle encapsulation was confirmed by confocal microscopy and infrared spectroscopy...
February 14, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29443486/effects-on-patients-of-variations-in-the-implementation-of-a-cardiometabolic-risk-intervention-program-in-montr%C3%A3-al
#3
Marie-Ève Beauregard, Sylvie Provost, Raynald Pineault, Dominique Grimard, José Pérez, Michel Fournier
INTRODUCTION: In 2011, the Agence de la santé et des services sociaux de Montréal (ASSSM), in partnership with the region's Centres de santé et de services sociaux (CSSS), coordinated the implementation of a program on cardiometabolic risk based on the Chronic Care Model. The program, intended for patients suffering from diabetes or hypertension, involved a series of individual follow-up appointments, group classes and exercise sessions. Our study assesses the impact on patient health outcomes of variations in the implementation of some aspects of the program among the six CSSSs taking part in the study...
February 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29443081/recombinant-collagen-i-peptide-microcarriers-for-cell-expansion-and-their-potential-use-as-cell-delivery-system-in-a-bioreactor-model
#4
Melva Suarez Muñoz, Davide Confalonieri, Heike Walles, Elisabeth M W M van Dongen, Gudrun Dandekar
Tissue engineering is a promising field, focused on developing solutions for the increasing demand on tissues and organs regarding transplantation purposes. The process to generate such tissues is complex, and includes an appropriate combination of specific cell types, scaffolds, and physical or biochemical stimuli to guide cell growth and differentiation. Microcarriers represent an appealing tool to expand cells in a three-dimensional (3D) microenvironment, since they provide higher surface-to volume ratios and mimic more closely the in vivo situation compared to traditional two-dimensional methods...
February 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29443073/percutaneous-contrast-echocardiography-guided-intramyocardial-injection-and-cell-delivery-in-a-large-preclinical-model
#5
Alejandro Giraldo, Jesús Talavera López, Maria Josefa Fernandez-Del-Palacio, Obdulio García-Nicolás, Juan Seva, Gavin Brooks, José María Moraleda
Cell and gene therapy are exciting and promising strategies for the purpose of cardiac regeneration in the setting of heart failure with reduced ejection fraction (HFrEF). Before they can be considered for use, and implemented in humans, extensive preclinical studies are required in large animal models to evaluate the safety, efficacy, and fate of the injectate (e.g., stem cells) once delivered into the myocardium. Small rodent models offer advantages (e.g., cost effectiveness, amenability for genetic manipulation); however, given inherent limitations of these models, the findings in these rarely translate into the clinic...
January 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442909/synthetic-polysaccharides-as-drug-carriers-synthesis-of-polyglucose-amphotericin-b-conjugates-and-in-vitro-evaluation-of-their-anti-fungal-and-anti-leishmanial-activities
#6
Vasanthan Ravichandran, Gayathri P Kothandaraman, Christian Bories, Philippe M Loiseau, A Jayakrishnan
While many naturally occurring polysaccharides have been widely used as drug carriers, there are two main drawbacks in their use: the first is their physical properties such as molecular weight, branching, type of glycosidic linkages and solubility depend on their source and the method of isolation and purification, the second is many of them are contaminated with proteins and protein removal is essential for preventing immune reactions. Synthetic polysaccharides on the other hand can be tailor made from their respective monomers with consistent physical properties and are, free from protein contamination, both being significant advantages in their use...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442814/evaluation-of-functional-sio%C3%A2-nanoparticles-toxicity-by-a-3d-culture-model
#7
Pascal Pellen-Mussi, Sylvie Tricot-Doleux, Chrystelle Neaime, Nicolas Nerambourg, Francisco Cabello-Hurtado, Stéphane Cordier, Fabien Grasset, Sylvie Jeanne
CONTEXT: as a kind of non-metal oxide SiO2 NPs have been extensively used in biomedicine, pharmaceuticals and other industrial manufacturing fields, such as DNA delivery, cancer therapy… Our group had developed a method based on microemulsion process to prepare SiO2 NPs incorporating photonic or magnetic nanocrystals and luminescent nanosized inorganic metal atom clusters. However, the toxicity of nanoparticles is known to be closely related to their physico-chemical characteristics and chemical composition...
May 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442800/characterization-of-articaine-loaded-poly-%C3%AE%C2%B5-caprolactone-nanocapsules-and-solid-lipid-nanoparticles-in-hydrogels-for-topical-formulations
#8
Nathalie Ferreira Silva de Melo, Estefânia Vangelie Ramos Campos, Michelle Franz-Montan, Eneida de Paula, Camila Morais Gonçalves da Silva, Cíntia Rodrigues Maruyama, Tatiane Pasquoto Stigliani, Renata de Lima, Daniele Ribeiro de Araújo, Leonardo Fernandes Fraceto
This work describes the development of poly-ε-caprolactone nanocapsules (PCL-NC) and solid lipid nanoparticles (SLN) aiming delivery for articaine (ATC), in order to improve its chemical stability in semi-solid preparations looking forward their use for skin delivery. The nanoparticles were characterized by size, polydispersity index, and pH. Cellular viability was evaluated using the MTT test and the in vitro release kinetics was determined using a two-compartment model. The hydrogels with nanoparticle suspensions were characterized considering their rheological aspects and in vitro permeation across artificial membranes...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442620/a-dual-ph-magnetic-responsive-nanocarrier-based-on-pegylated-fe%C3%A2-o%C3%A2-nanoparticles-for-doxorubicin-delivery
#9
Fan Ji, Kun Zhang, Jie Li, Yuanliang Gu, Jinshun Zhao, Jianfeng Zhang
Cancer chemotherapy has limitations such as nonselective distribution of drugs, detrimental side effects on normal tissues; here we reported a smart pH and magnetic sensitive drug delivery system (DDS) based on PEGylated Fe3O4 superparamagnetic nanoparticles. The citric-coated Fe3O4 (CIO) nanoparticles were firstly synthesized and further functionalized by biocompatible poly(ethylene glycol) bis(carboxymethyl ether) (COOH-PEG-COOH), thus PEGylated CIO (GCIO) nanoparticles were obtained. Doxorubicin (DOX) was conjugated as a model drug to the nanoparticles via hydrazone bond...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442050/inhibiting-the-proliferation-migration-and-invasion-of-triple-negative-breast-cancer-cells-through-anti-tumor-human-serum-albumin-nanoparticles-loading-aziditaxel-as-a-novel-taxane-derivative
#10
Li-Qing Chen, Zhe-Ming Zhang, Wei Huang, Zhong-Gao Gao, Wei-Shuo Fang, Ming-Ji Jin, Lian Yu
Triple negative breast cancer (TNBC) is a severe breast cancer subtype with the high mortality rate, and still is lack of effective therapeutic means so far. Aziditaxel, a water-insoluble compound, is a novel taxane derivative with strong anti-tumor activity. In this study, we constructed an aziditaxel-loaded nano drug delivery system using human serum albumin as a carrier, and further investigated its anti-tumor effect on TNBC in vitro. An emulsion solvent evaporation method was employed to prepare aziditaxel-loaded human serum albumin nanoparticles (AT-NPs)...
March 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29442039/design-and-production-of-methyl-jasmonate-nanoemulsions-using-experimental-design-technique-and-evaluation-of-its-anti-cancer-efficacy
#11
K Habibi, H Sepehri, L Delphi, M H Mirjalili, H Rafati
Methyl jasmonate (MJ), a plant-derived stress hormone, has been shown to be a promising anti-cancer agent with high selectivity toward cancerous cells. The aim of the present study was to design a MJ loaded nanoemulsion (NE) to overcome the low MJ water solubility and also improve its anti-cancer efficiency. Box-Behnken design (BBD) was employed to optimize the composition effect of three independent manufacturing variables on two responses including average droplet size and poly dispersity index (PDI). ANOVA analysis indicated that both of the studied responses were well fitted by resultant quadratic models with the coefficient of determinations (R2) 0...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440934/prevalence-and-risk-factors-for-maternal-mortality-in-referral-hospitals-in-nigeria-a-multicenter-study
#12
Lorretta F Ntoimo, Friday E Okonofua, Rosemary N Ogu, Hadiza S Galadanci, Mohammed Gana, Ola N Okike, Kingsley N Agholor, Rukiyat A Abdus-Salam, Adetoye Durodola, Eghe Abe, Abdullahi J Randawa
Introduction: While reports from individual hospitals have helped to provide insights into the causes of maternal mortality in low-income countries, they are often limited for policymaking at national and subnational levels. This multisite study was designed to determine maternal mortality ratios (MMRs) and identify the risk factors for maternal deaths in referral health facilities in Nigeria. Methods: A pretested study protocol was used over a 6-month period (January 1-June 30, 2014) to obtain clinical data on pregnancies, births, and maternal deaths in eight referral hospitals across eight states and four geopolitical zones of Nigeria...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29440889/a-novel-therapeutic-strategy-for-cartilage-diseases-based-on-lipid-nanoparticle-rnai-delivery-system
#13
Shaowei Wang, Xiaochun Wei, Xiaojuan Sun, Chongwei Chen, Jingming Zhou, Ge Zhang, Heng Wu, Baosheng Guo, Lei Wei
Background: Cartilage degeneration affects millions of people but preventing its degeneration is a big challenge. Although RNA interference (RNAi) has been used in human trials via silencing specific genes, the cartilage RNAi has not been possible to date because the cartilage is an avascular and very dense tissue with very low permeability. Purpose: The objective of this study was to develop and validate a novel lipid nanoparticle (LNP)-siRNA delivery system that can prevent cartilage degeneration by knocking down specific genes...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29440875/experimental-and-molecular-modeling-approach-to-optimize-suitable-polymers-for-fabrication-of-stable-fluticasone-nanoparticles-with-enhanced-dissolution-and-antimicrobial-activity
#14
Shaimaa Ahmed, Thirumala Govender, Inamullah Khan, Nisar Ur Rehman, Waqar Ali, Syed Muhammad Hassan Shah, Shahzeb Khan, Zahid Hussain, Riaz Ullah, Mansour S Alsaid
Background and aim: The challenges with current antimicrobial drug therapy and resistance remain a significant global health threat. Nanodrug delivery systems are playing a crucial role in overcoming these challenges and open new avenues for effective antimicrobial therapy. While fluticasone (FLU), a poorly water-soluble corticosteroid, has been reported to have potential antimicrobial activity, approaches to optimize its dissolution profile and antimicrobial activity are lacking in the literature...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29440292/a-dna-interacting-payload-designed-to-eliminate-cross-linking-improves-the-therapeutic-index-of-antibody-drug-conjugates-adcs
#15
Michael L Miller, Manami Shizuka, Alan Wilhelm, Paulin Salomon, Emily E Reid, Leanne Lanieri, Surina Sikka, Erin K Maloney, Lauren Harvey, Qifeng Qiu, Katie E Archer, Chen Bai, Dilrukshi Vitharana, Luke Harris, Rajeeva Singh, Jose F Ponte, Nicholas C Yoder, Yelena Kovtun, Katharine C Lai, Olga Ab, Jan Pinkas, Thomas A Keating, Ravi V J Chari
Tumor-selective delivery of cytotoxic agents in the form of antibody-drug conjugates (ADCs) is now a clinically validated approach for cancer treatment. In an attempt to improve the clinical success rate of ADCs, emphasis has been recently placed on the use of DNA-cross-linking pyrrolobenzodiazepine compounds as the payload. Despite promising early clinical results with this class of ADCs, doses achievable have been low due to systemic toxicity. Here we describe the development of a new class of potent DNA-interacting agents wherein changing the mechanism of action from a cross-linker to a DNA alkylator improves the tolerability of the ADC...
February 13, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29440158/risk-factors-and-between-hospital-variation-of-caesarean-section-in-denmark-a-cohort-study
#16
Sonja Wehberg, Rikke Guldberg, Kim Oren Gradel, Ulrik Schiøler Kesmodel, Lis Munk, Charlotte Brix Andersson, Line Riis Jølving, Jan Nielsen, Bente Mertz Nørgård
OBJECTIVES: The aim of this study was to estimate the effects of risk factors on elective and emergency caesarean section (CS) and to estimate the between-hospital variation of risk-adjusted CS proportions. DESIGN: Historical registry-based cohort study. SETTINGS AND PARTICIPANTS: The study was based on all singleton deliveries in hospital units in Denmark from January 2009 to December 2012. A total of 226 612 births by 198 590 mothers in 29 maternity units were included...
February 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29439895/adding-value-to-total-joint-arthroplasty-care-in-an-academic-environment-the-utah-experience
#17
Christopher E Pelt, Mike B Anderson, Jill A Erickson, Jeremy M Gililland, Christopher L Peters
BACKGROUND: Adding value in a university-based academic health care system provides unique challenges when compared to other health care delivery models. Herein, we describe our experience in adding value to joint arthroplasty care at the University of Utah, where the concept of value-based health care reform has become an embraced and driving force. METHODS: To improve the value, new resources were needed for care redesign, physician leadership, and engagement in alternative payment models...
February 10, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29439712/trovafloxacin-attenuates-neuroinflammation-and-improves-outcome-after-traumatic-brain-injury-in-mice
#18
Charu Garg, Joon Ho Seo, Jayalakshmi Ramachandran, Ji Meng Loh, Frances Calderon, Jorge E Contreras
BACKGROUND: Trovafloxacin is a broad-spectrum antibiotic, recently identified as an inhibitor of pannexin-1 (Panx1) channels. Panx1 channels are important conduits for the adenosine triphosphate (ATP) release from live and dying cells that enhances the inflammatory response of immune cells. Elevated extracellular levels ATP released upon injury activate purinergic pathways in inflammatory cells that promote migration, proliferation, phagocytosis, and apoptotic signals. Here, we tested whether trovafloxacin administration attenuates the neuroinflammatory response and improves outcomes after brain trauma...
February 13, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29439670/phase-i-study-of-an-active-immunotherapy-for-asymptomatic-phase-lymphoplasmacytic-lymphoma-with-dna-vaccines-encoding-antigen-chemokine-fusion-study-protocol
#19
Sheeba K Thomas, Soung-Chul Cha, D Lynne Smith, Kun Hwa Kim, Sapna R Parshottam, Sheetal Rao, Michael Popescu, Vincent Y Lee, Sattva S Neelapu, Larry W Kwak
BACKGROUND: There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicating that the immune system is involved in the therapeutic effect of these agents; this finding strongly supports the use of cancer vaccine strategies. Lymphoplasmacytic lymphoma (LPL) is a low grade, incurable disease featuring an abnormal proliferation of Immunoglobulin (Ig)-producing malignant cells...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29439624/telepractice-delivery-of-family-centred-early-intervention-for-children-who-are-deaf-or-hard-of-hearing-a-scoping-review
#20
Melissa McCarthy, Greg Leigh, Michael Arthur-Kelly
Introduction The use of telepractice, a method of delivering services through telecommunications technologies that provides two-way, synchronous audio and video signals in real-time, is becoming increasingly commonplace in early childhood education and intervention for children who are deaf or hard of hearing. Although the use of telepractice has been validated in the health sector as a viable and effective alternative to in-person service provision, evidence to support its use in the delivery of family-centred early intervention is still emerging...
January 1, 2018: Journal of Telemedicine and Telecare
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