keyword
MENU ▼
Read by QxMD icon Read
search

Delivery models

keyword
https://www.readbyqxmd.com/read/29222640/clinical-effect-of-emergency-cervical-cerclage-and-elective-cervical-cerclage-on-pregnancy-outcome-in-the-cervical-incompetent-pregnant-women
#1
Qin Chen, Guiying Chen, Nan Li
PURPOSE: To compare the clinical effect of emergency cervical cerclage and elective cervical cerclage on pregnancy outcome in the cervical-incompetent pregnant women. METHODS: Literature was searched from the databases of Pubmed, Embase and Google scholar. The fixed or random effects model was used to calculate pooled risk ratios on the basis of heterogeneity. Meta-regression, sensitive analysis, subgroup analysis, and publication bias assessment were also conducted to confirm the results according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009...
December 8, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29222602/endoscopic-ultrasound-guided-biliary-drainage-using-a-newly-designed-metal-stent-with-a-thin-delivery-system-a-preclinical-study-in-phantom-and-porcine-models
#2
Kosuke Minaga, Masayuki Kitano, Masahiro Itonaga, Hajime Imai, Takeshi Miyata, Kentaro Yamao, Takashi Tamura, Junya Nuta, Kenji Warigaya, Masatoshi Kudo
PURPOSE: This study was designed to evaluate the feasibility and safety of a newly designed self-expandable metal stent for endoscopic ultrasound-guided biliary drainage (EUS-BD) when it was delivered via three different stent delivery systems: a 7.5Fr delivery catheter with a bullet-shaped tip (7.5Fr-bullet), a 7Fr catheter with a bullet-shaped tip (7Fr-bullet), or a 7Fr catheter with a tee-shaped tip (7Fr-tee). METHODS: This experimental study utilized a porcine model of biliary dilatation involving ten pigs...
December 8, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29221962/drug-delivery-and-tissue-engineering-to-promote-wound-healing-in-the-immunocompromised-host-current-challenges-and-future-directions
#3
Alexander M Tatara, Dimitrios P Kontoyiannis, Antonios G Mikos
As regenerative medicine matures as a field, more promising technologies are being translated from the benchtop to the clinic. However, many of these strategies are designed with otherwise healthy hosts in mind and validated in animal models without other co-morbidities. In reality, many of the patient populations benefiting from drug delivery and tissue engineering-based devices to enhance wound healing also have significant underlying immunodeficiency. Specifically, patients suffering from diabetes, malignancy, human immunodeficiency virus, post organ transplantation, and other compromised states have significant pleotropic immune defects that affect wound healing...
December 5, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29220342/effect-of-penetration-enhancers-on-the-percuaneous-delivery-of-hormone-replacement-actives
#4
John O Trimble, Bob Light
Transdermal compositions for hormone replacement are comprised of exogenous hormones that are biochemically similar to those produced endogenously by the ovaries or elsewhere in the body. In this work, estradiol, estriol, and testosterone were loaded in transdermal vehicles, prepared using one of three selected penetration enhancer mixtures: Vehicle 1 (olive oil and oleic acid), Vehicle 2 (isopropyl palmitate and lecithin), and Vehicle 3 (isopropyl myristate and lecithin). The influence of penetration enhancers on transdermal delivery was evaluated using Franz-type diffusion cells and Normal Human 3D Model of Epidermal Tissue...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29219119/density-overwrites-of-internal-tumor-volumes-in-intensity-modulated-proton-therapy-plans-for-mobile-lung-tumors
#5
Pablo Botas, Clemens Grassberger, Gregory Sharp, Harald Paganetti
The purpose of this study was to investigate Internal Tumor Volume (ITV) density overwrite strategies to minimize Intensity Modulated Proton Therapy (IMPT) plan degradation of mobile lung tumors. Four planning paradigms were compared for nine lung cancer patients. IGTV and ICTV structures were defined encompassing their respective volumes in every 4DCT phase. The paradigms use different planning CT (pCT) created from the Average Intensity Projection (AIP) of the 4DCT, overwriting the density within the IGTV to account for movement...
December 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29218795/revisiting-bevacizumab%C3%A2-%C3%A2-cytotoxics-scheduling-using-mathematical-modeling-proof-of-concept-study-in-experimental-non-small-cell-lung-carcinoma
#6
Diane-Charlotte Imbs, Raouf El Cheikh, Arnaud Boyer, Joseph Ciccolini, Céline Mascaux, Bruno Lacarelle, Fabrice Barlesi, Dominique Barbolosi, Sébastien Benzekry
Concomitant administration of bevacizumab and pemetrexed-cisplatin is a common treatment for advanced nonsquamous non-small cell lung cancer (NSCLC). Vascular normalization following bevacizumab administration may transiently enhance drug delivery, suggesting improved efficacy with sequential administration. To investigate optimal scheduling, we conducted a study in NSCLC-bearing mice. First, experiments demonstrated improved efficacy when using sequential vs. concomitant scheduling of bevacizumab and chemotherapy...
December 7, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29218630/differential-reactivity-of-closely-related-zinc-ii-binding-metallothioneins-from-the-plant-arabidopsis-thaliana
#7
Hasan T Imam, Claudia A Blindauer
The dynamics of metal binding to and transfer from metalloproteins involved in metal homeostasis are important for understanding cellular distribution of metal ions. The dicotyledonous plant Arabidopsis thaliana has two type 4 seed-specific metallothionein homologues, MT4a and MT4b, with likely roles in zinc(II) homeostasis. These two metallothioneins are 84% identical, with full conservation of all metal-binding cysteine and histidine residues. Yet, differences in their spatial and temporal expression patterns suggested divergence in their biological roles...
December 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29218267/radiomics-in-precision-medicine-for-lung-cancer
#8
REVIEW
Julie Constanzo, Lise Wei, Huan-Hsin Tseng, Issam El Naqa
With the improvement of external radiotherapy delivery accuracy, such as intensity-modulated and stereotactic body radiation therapy, radiation oncology has recently entered in the era of precision medicine. Despite these precise irradiation modalities, lung cancers remain one of the most aggressive human cancers worldwide, possibly because of diverse genotypic alterations that drive and maintain lung tumorigenesis. It has been long recognized that imaging could aid in the diagnosis, tumor delineation, and monitoring of lung cancer...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29218236/psmb5-plays-a-dual-role-in-cancer-development-and-immunosuppression
#9
Chih-Yang Wang, Chung-Yen Li, Hui-Ping Hsu, Chien-Yu Cho, Meng-Chi Yen, Tzu-Yang Weng, Wei-Ching Chen, Yu-Hsuan Hung, Kuo-Ting Lee, Jui-Hsiang Hung, Yi-Ling Chen, Ming-Derg Lai
Tumor progression and metastasis are dependent on the intrinsic properties of tumor cells and the influence of microenvironment including the immune system. It would be important to identify target drug that can inhibit cancer cell and activate immune cells. Proteasome β subunits (PSMB) family, one component of the ubiquitin-proteasome system, has been demonstrated to play an important role in tumor cells and immune cells. Therefore, we used a bioinformatics approach to examine the potential role of PSMB family...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29217763/improved-tumor-penetration-and-single-cell-targeting-of-antibody-drug-conjugates-increases-anticancer-efficacy-and-host-survival
#10
Cornelius Cilliers, Bruna Menezes, Ian Nessler, Jennifer Linderman, Greg Thurber
Current antibody-drug conjugates (ADC) have made advances in engineering the antibody, linker, conjugation site, small molecule payload and drug-to-antibody ratio (DAR). However, the relationship between heterogeneous intratumoral distribution and efficacy of ADC is poorly understood. Here we compared trastuzumab and ado-trastuzumab emtansine (T-DM1) to study the impact of ADC tumor distribution on efficacy. In a mouse xenograft model insensitive to trastuzumab, co-administration of trastuzumab with a fixed dose of T-DM1 at 3:1 and 8:1 ratios dramatically improved ADC tumor penetration and resulted in twice the improvement in median survival compared to T-DM1 alone...
December 7, 2017: Cancer Research
https://www.readbyqxmd.com/read/29217501/a-peer-led-electronic-mental-health-recovery-app-in-an-adult-mental-health-service-study-protocol-for-a-pilot-trial
#11
Amelia Gulliver, Michelle Banfield, Julia Reynolds, Sarah Miller, Connie Galati, Alyssa R Morse
BACKGROUND: There is growing demand for peer workers (people who use their own lived experience to support others in their recovery) to work alongside consumers to improve outcomes and recovery. Augmenting the workforce with peer workers has strong capacity to enhance mental health and recovery outcomes and make a positive contribution to the workforce within mental health systems and to the peer workers themselves. Technology-based applications are highly engaging and desirable methods of service delivery...
December 7, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29217475/in-vitro-drug-release-and-in-vivo-safety-of-vitamin-e-and-cysteamine-loaded-contact-lenses
#12
Phillip Dixon, Richard C Fentzke, Arnab Bhattacharya, Aditya Konar, Sarbani Hazra, Anuj Chauhan
Cystinosis is an orphan disease caused by a genetic mutation that leads to deposition of cystine crystals in many organs including cornea. Ophthalmic manifestation of the disease can be treated with hourly instillation of cysteamine eye drops. The hourly eye drop instillation is tedious to the patients leading to poor compliance and additionally, significant degradation of the drug occurs within one week of opening the bottle, which further complicates this delivery approach. This paper focuses on designing a contact lens to treat the disease with improved efficacy compared to eye drops, and also exploring safety of the drug eluding contact lens in an animal model...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29217473/impact-of-digestion-on-the-transport-of-dextran-loaded-self-emulsified-nanoemulsion-through-mdck-epithelial-cell-monolayer-and-rat-intestines
#13
Pulkit Khatri, Jun Shao
Many of the lipids and surfactants used to prepare the self-emulsified nanoemulsion (SEN) are subjected to the gastro-intestinal enzymatic digestion, which may affect the absorption of the loaded drug. The present study was to investigate the impact of such digestion on the transport of hydrophilic macromolecules (10-kDa dextran as the model compound) loaded in SEN through the MDCK cell monolayer and ex-vivo rat intestines. FITC-labeled dextran (FD) was loaded inside the inner oil phase of SEN by the formation of FD-phospholipid solid dispersion (FDPS)...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29217389/competencies-for-engaging-high-needs-patients-in-primary-care
#14
Michael J Yedidia
BACKGROUND: Patients who heavily utilize hospitals and emergency departments frequently have complex needs requiring services spanning medical, behavioral, and social service sectors. This study identifies essential competencies for caring for high-needs patients and highlights their importance to primary care delivery. METHODS: Transcripts of in-depth interviews with 30 clinical and administrative staff at 23 complex care programs across the United States were analyzed using standard qualitative techniques...
December 4, 2017: Healthcare
https://www.readbyqxmd.com/read/29217184/formulation-of-novel-chitosan-guargum-based-hydrogels-for-sustained-drug-release-of-paracetamol
#15
Amtul Jamil Sami, Madeeha Khalid, Tahir Jamil, Saira Aftab, Sermad Ahmad Mangat, A R Shakoori, S Iqbal
The report presents the formulation of hydrogel based on biopolymers chitosan and guar gum after cross-linking for sustained release of a commonly used orally prescribed analgesic Paracetamol. The oral ingestion of Paracetamol is associated with complications of the gastric tract and liver metabolism that can be effectually avoided by using transdermal drug delivery systems. The formulated transdermal patch was characterized by physicochemical properties including swelling, bonding pattern (using FTIR Fourier Transform Infra-Red and Scanning Electron Microscopy SEM) and antimicrobial activity...
December 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29217132/mobile-phone-sensors-and-supervised-machine-learning-to-identify-alcohol-use-events-in-young-adults-implications-for-just-in-time-adaptive-interventions
#16
Sangwon Bae, Tammy Chung, Denzil Ferreira, Anind K Dey, Brian Suffoletto
BACKGROUND: Real-time detection of drinking could improve timely delivery of interventions aimed at reducing alcohol consumption and alcohol-related injury, but existing detection methods are burdensome or impractical. OBJECTIVE: To evaluate whether phone sensor data and machine learning models are useful to detect alcohol use events, and to discuss implications of these results for just-in-time mobile interventions. METHODS: 38 non-treatment seeking young adult heavy drinkers downloaded AWARE app (which continuously collected mobile phone sensor data), and reported alcohol consumption (number of drinks, start/end time of prior day's drinking) for 28days...
November 27, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29216970/current-research-gaps-a-global-systematic-review-of-hiv-and-sexually-transmissible-infections-among-transgender-populations
#17
Sarah MacCarthy, Tonia Poteat, Zhiyu Xia, Nicolette L Roque, Ashley Hyun Jin Kim, Stefan Baral, Sari L Reisner
Transgender populations are heavily burdened by HIV and other sexually transmissible infections (STIs). However, data on co-infection with HIV and STIs among transgender people are limited. A systematic review was conducted of peer-reviewed articles and conference abstracts between January 2010 and November 2015 that focussed on HIV and STI infections among transgender populations globally. The literature was synthesised and opportunities for improving health research were commented on. Few studies reported HIV-STI co-infection (n=4), while the majority of studies reported HIV and STI infections separately (n=23)...
October 2017: Sexual Health
https://www.readbyqxmd.com/read/29216765/using-the-intervention-mapping-and-behavioral-intervention-technology-frameworks-development-of-an-mhealth-intervention-for-physical-activity-and-sedentary-behavior-change
#18
Artur Direito, Deirdre Walsh, Moohamad Hinbarji, Rami Albatal, Mark Tooley, Robyn Whittaker, Ralph Maddison
Few interventions to promote physical activity (PA) adapt dynamically to changes in individuals' behavior. Interventions targeting determinants of behavior are linked with increased effectiveness and should reflect changes in behavior over time. This article describes the application of two frameworks to assist the development of an adaptive evidence-based smartphone-delivered intervention aimed at influencing PA and sedentary behaviors (SB). Intervention mapping was used to identify the determinants influencing uptake of PA and optimal behavior change techniques (BCTs)...
December 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29216752/an-acryl-resin-based-swellable-microneedles-for-controlled-release-intradermal-delivery-of-granisetron
#19
Guozhong Yang, Meilin He, Suohui Zhang, Man Wu, Yunhua Gao
Swellable microneedles (SMNs) are made of hydrogels and can deliver drug with controlled delivery rate by the cross-link density of the hydrogel. In this study, an acryl resin-based SMNs was developed for poorly water-soluble drugs. The making process of the SMNs is very simple and only need 60 min. The SMNs has high mechanical strength and is not easily broken. In-vitro release of SMNs-loaded model drug, granisetron base (GRB), was investigated. The results showed that 7 days controlled release of GRB was obtained when SMNs contained pore-foaming agents (1...
December 8, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29216748/quality-of-care-for-patients-with-diabetes-and-mulitmorbidity-registered-at-nurse-practitioner-led-clinics
#20
Roberta Heale, Elizabeth Wenghofer, Susan James, Marie-Luce Garceau
Background Nurse Practitioner-Led Clinics are a new model of primary healthcare in Ontario. Nurse Practitioner-Led Clinics are distinctive in that nurse practitioners are the primary care providers working with an interprofessional team. There have been no evaluations of the quality of care within the Nurse Practitioner-Led Clinic model. Purpose Evaluation of the Nurse Practitioner-Led Clinic model, specifically for complex clinical presentations, will provide insights that may be used to inform improvements to the delivery of care in the Nurse Practitioner-Led Clinics...
January 1, 2017: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
keyword
keyword
80720
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"