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Peter Winskill, Wendy E Harrison, Michael D French, Matthew A Dixon, Bernadette Abela-Ridder, María-Gloria Basáñez
BACKGROUND: The pork tapeworm, Taenia solium, and associated human infections, taeniasis, cysticercosis and neurocysticercosis, are serious public health problems, especially in developing countries. The World Health Organization (WHO) has set goals for having a validated strategy for control and elimination of T. solium taeniasis/cysticercosis by 2015 and interventions scaled-up in selected countries by 2020. Timely achievement of these internationally-endorsed targets requires that the relative benefits and effectiveness of potential interventions be explored rigorously within a quantitative framework...
February 9, 2017: Parasites & Vectors
Vedantam Rajshekhar
Neurocysticercosis (NCC) is the most common single cause of seizures/epilepsy in India and several other endemic countries throughout the world. It is also the most common parasitic disease of the brain caused by the cestode Taenia solium or pork tapeworm. The diagnosis of NCC and the tapeworm carrier (taeniasis) can be relatively inaccessible and expensive for most of the patients. In spite of the introduction of several new immunological tests, neuroimaging remains the main diagnostic test for NCC. The treatment of NCC is also mired in controversy although, there is emerging evidence that albendazole (a cysticidal drug) may be beneficial for patients by reducing the number of seizures and hastening the resolution of live cysts...
September 2016: Indian Journal of Medical Research
Rebecca L Hall, Britta Anderson, Jay Schulkin, Paul T Cantey, Susan P Montgomery, Jeffrey L Jones
An estimated 50 million persons worldwide are infected with cysticerci, the larval forms of the Taenia solium tapeworm. Neurocysticercosis can cause seizures, epilepsy, and hydrocephalus, and fatal cases have been reported in the United States in immigrants and in travelers returning from endemic countries. Pregnant women with symptomatic neurocysticercosis present treatment challenges, whereas those with the adult tapeworm infection (i.e., taeniasis) can put their infants and other family members, as well as obstetrician-gynecologists and their staff, at risk for cysticercosis...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
José Navarrete-Perea, Bárbara Moguel, Raúl José Bobes, Nelly Villalobos, Julio César Carrero, Edda Sciutto, Xavier Soberón, Juan Pedro Laclette
Taeniasis/cysticercosis caused by the tapeworm Taenia solium is a parasite disease transmitted among humans and pigs, the main intermediate host. The larvae/cysts can lodge in several tissues of the pig, i.e. skeletal muscles and different locations of the central nervous system. The molecular mechanisms associated to tissue preferences of the cysts remain poorly understood. The major public health concern about this zoonosis is due to the human infections by the larval form in the central nervous system, causing a highly pleomorphic and debilitating disease known as neurocysticercosis...
January 2017: Experimental Parasitology
Francisco Rogerlândio Martins-Melo, Alberto Novaes Ramos, Marta Guimarães Cavalcanti, Carlos Henrique Alencar, Jorg Heukelbach
Neurocysticercosis (NCC) is an important cause of severe neurological disease mainly in low- and middle-income countries, but data on NCC mortality from endemic areas are scarce. Here we analysed the epidemiological patterns of NCC-related mortality in Brazil. We included all deaths recorded in Brazil between 2000 and 2011, in which NCC was mentioned on death certificates, either as underlying or as associated cause of death. NCC was identified in 1829/12,491,280 deaths (0.015%), 1130 (61.8%) as underlying cause, and 699 (38...
January 2017: Acta Tropica
Anna L Okello, Lian Thomas, Phouth Inthavong, Amanda Ash, Boualam Khamlome, Chattouphone Keokamphet, Kim Newberry, Charles G Gauci, Sarah Gabriël, Pierre Dorny, Rc Andrew Thompson, Marshall W Lightowlers, John Allen
Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later...
January 2017: Acta Tropica
Lucy B Gripper, Susan C Welburn
Neurocysticercosis (NCC) is the most common parasitic disease of the human central nervous system (CNS), a pleomorphic disease with a diverse array of clinical manifestations. The infection is pleomorphic and dependent on a complex range of interconnecting factors, including number and size of the cysticerci, their stage of development and localisation within the brain with resulting difficulties in accurate diagnosis and staging of the disease. This review examines the factors that contribute to the accurate assessment of NCC distribution and transmission that are critical to achieving robust disease burden calculations...
February 2017: Acta Tropica
Danilo Solano, Juan Carlos Navarro, Antonio León-Reyes, Washington Benítez-Ortiz, Richar Rodríguez-Hidalgo
Tapeworms Taenia solium and Taenia saginata are the causative agents of taeniasis/cysticercosis. These are diseases with high medical and veterinary importance due to their impact on public health and rural economy in tropical countries. The re-emergence of T. solium as a result of human migration, the economic burden affecting livestock industry, and the large variability of symptoms in several human cysticercosis, encourage studies on genetic diversity, and the identification of these parasites with molecular phylogenetic tools...
December 2016: Experimental Parasitology
M Vilhena, A G Fonseca, S Dias, J Marques DA Silva, J Torgal
Cysticercosis, a leading cause of acquired epilepsy in developing countries, has been controlled or eradicated in industrialized countries. This paradigm has recently been challenged, with human neurocysticercosis (NCC) being increasingly diagnosed in these countries. In order to assess the NCC burden in Portugal, a retrospective study on NCC hospitalizations (2006-2013) was conducted based on the national database on hospital morbidity: 357 hospitalized cases were detected. NCC was most frequent in the following age groups: 20-64 years (n = 197, 55·2%) >64 years (n = 111, 31·1%), and <20 years (n = 49, 13·7%)...
January 2017: Epidemiology and Infection
Héctor Julián Canaval Zuleta
Dear editor. We have published an article about the role of the endoscopy in the Taeniosis. I will try to clarify some doubts and misinformation about it, as well Galan-Puchades MT suggests.
October 2016: Revista Española de Enfermedades Digestivas
Carla Muñoz-Antolí, Raimundo Seguí, M José Irisarri-Gutiérrez, Rafael Toledo, José Guillermo Esteban
No abstract text is available yet for this article.
September 3, 2016: Gastroenterología y Hepatología
M Teresa Galán-Puchades, Màrius V Fuentes
An epidemiological study on taeniasis and cysticercosis in northern India has recently updated the epidemiology of Taenia asiatica. Practically, all the detected cases of taeniasis were caused by T. asiatica, cited for the first time in humans in that country. The finding widens the geographical distribution of T. asiatica, a species wrongly considered an exclusive South-Eastern Asian parasite. Due to the introduction of molecular techniques in Taenia diagnosis, the species is slowly showing its true distribution...
November 2016: Parasitology Research
Satyendra K Singh, Kashi N Prasad, Aloukick K Singh, Kamlesh K Gupta, Ranjeet S Chauhan, Amrita Singh, Avinash Singh, Ravi P Rai, Binod K Pati
Taenia solium is the major cause of taeniasis and cysticercosis/neurocysticercosis (NCC) in the developing countries including India, but the existence of other Taenia species and genetic variation have not been studied in India. So, we studied the existence of different Taenia species, and sequence variation in Taenia isolates from human (proglottids and cysticerci) and swine (cysticerci) in North India. Amplification of cytochrome c oxidase subunit 1 gene (cox1) was done by polymerase chain reaction (PCR) followed by sequencing and phylogenetic analysis...
October 2016: Parasitology Research
Hector H Garcia, Armando E Gonzalez, Victor C W Tsang, Seth E O'Neal, Fernando Llanos-Zavalaga, Guillermo Gonzalvez, Jaime Romero, Silvia Rodriguez, Luz M Moyano, Viterbo Ayvar, Andre Diaz, Allen Hightower, Philip S Craig, Marshall W Lightowlers, Charles G Gauci, Elli Leontsini, Robert H Gilman
BACKGROUND: Taeniasis and cysticercosis are major causes of seizures and epilepsy. Infection by the causative parasite Taenia solium requires transmission between humans and pigs. The disease is considered to be eradicable, but data on attempts at regional elimination are lacking. We conducted a three-phase control program in Tumbes, Peru, to determine whether regional elimination would be feasible. METHODS: We systematically tested and compared elimination strategies to show the feasibility of interrupting the transmission of T...
June 16, 2016: New England Journal of Medicine
Emmanuel S Swai, Miran B Miran, Ayubu A Kasuku, Jahashi Nzalawahe
The prevalence of taeniasis was determined during the period January to April 2013 in a cross-sectional study of non-descript domestic dogs from the livestock-wildlife ecosystem of Ngorongoro, Tanzania. Taeniid eggs were determined by screening faecal samples using the formalin-ether sedimentation technique. Predisposing factors for dog infection were assessed in relation to demographic, husbandry and management data. Of the 205 faecal samples screened, 150 (73.2%) were positive for taeniid eggs. The prevalence of dogs harbouring taeniid eggs was 80%, 30...
May 24, 2016: Onderstepoort Journal of Veterinary Research
Akihiro Sato, Itaru Nakamura, Hiroaki Fujita, Shinji Fukushima, Yasutaka Mizuno, Takeshi Fujii, Tetsuya Matsumoto
We report a case of neurocysticercosis concurrent with taeniasis in a 31-year-old woman. The patient presented with a headache and diplopia. Oculomotor disturbances with a left adduction deficit were observed. Fundoscopy revealed papilledema. Additionally, computed tomography of the brain revealed more than 20 small cysts within the parenchyma, most of which were associated with ring enhancement. Moreover, serum antibody testing (Western blotting) for Taenia solium-cysticerci was positive. The patient received albendazole and corticosteroids, and progressive resolution of the neurological symptoms and papilledema was observed starting approximately three days after administration...
2016: Internal Medicine
S Gabriël, P Dorny, K E Mwape, C Trevisan, U C Braae, P Magnussen, S Thys, C Bulaya, I K Phiri, C S Sikasunge, C Makungu, S Afonso, Q Nicolau, M V Johansen
Taenia solium taeniasis/cysticercosis is a neglected parasitic zoonosis with significant economic and public health impacts. Control measures can be broadly grouped into community health education, improvements in hygiene and sanitary conditions, proper meat handling at household and community level, improved standards of meat inspection, pig management, treatment of individual patients and possibly human populations, and treatment and/or vaccination of porcine populations. This manuscript looks critically into currently existing control options and provides suggestions on which (combination of) tools would be most effective in the control of T...
January 2017: Acta Tropica
Rosa Domínguez-Roldan, Claudia Hallal-Calleros, Edda Sciutto, Marisela Hernández, Virginio Aguirre-Flores, Sara García-Jiménez, Armida Báez-Saldaña, Fernando Iván Flores-Pérez
INTRODUCTION: It has been reported that behavioral changes relate to infection in different parasitoses. However, the relation between the extent of the behavioral changes and the magnitude of the infection has been scarcely studied. The aim of this study was to evaluate the relationship between different doses of infection and the behavioral changes induced in the experimental Taenia pisiformis taeniasis in golden hamsters. METHODS: Groups of nine hamsters were infected with three or six T...
July 2016: Experimental Parasitology
Narin Preyavichyapugdee, Manaw Sangfuang, Saowapark Chaiyapum, Suwatcharaporn Sriburin, Yupa Pootaeng-on, Phiraphol Chusongsang, Wannee Jiraungkoorskul, Mananya Preyavichyapugdee, Prasert Sobhon
Puag-Haad is a traditional anthelmintic drug used to treat taeniasis in Thailand and Lao PDR. It is derived from the aqueous extract of the plant Artocarpus lakoocha. We investigated the in vitro anthelmintic properties of Puag-Haad against Schistosoma mansoni. Adult worms were incubated in M-199 medium containing 250, 500 and 750 μg/ml of Puag-Haad or praziquantel (PZQ) at a concentration of 175 μg/ml for 3, 6, 12 and 24 hours. The relative motility (RM value), survival index (SI) and tegument alterations seen under scanning electron microscope were assessed at each incubation time...
January 2016: Southeast Asian Journal of Tropical Medicine and Public Health
Ali Bekraki, Khalil Hanna
Complicated Taeniasis necessitating surgical intervention is extremely rare and is usually reported to occur in the distal ileal region of the Gastrointestinal tract. A case of peritonitis secondary to proximal jejunal perforation due to Taenia saginata is presented. Preoperative evaluation suggested the diagnosis of acute duodenal ulcer perforation. Although no real change in management and outcome is present, Taenia remains an exceptional direct cause of intestinal perforation, and should be kept on the list of differential diagnosis of peritonitis and acute abdomen in endemic geographical locations...
March 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
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