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https://www.readbyqxmd.com/read/29137663/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-worldwide-patent-families
#1
Folahanmi Tomiwa Akinsolu, Vitor Nobre de Paiva, Samuel Santos Souza, Orsolya Varga
BACKGROUND: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws...
November 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29016332/porcine-cysticercosis-possible-cross-reactivity-of-taenia-hydatigena-to-gp50-antigen-in-the-enzyme-linked-immunoelectrotransfer-blot-assay
#2
Claudio Muro, Luis A Gomez-Puerta, Robert H Flecker, Ricardo Gamboa, Percy Vilchez Barreto, Pierre Dorny, Victor C W Tsang, Robert H Gilman, Armando E Gonzalez, Hector H Garcia Lescano, Seth E O'Neal, For The Cysticercosis Working Group In Peru
The lentil lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB, reported sensitivity 99% and specificity 100%) is used as a serologic marker of exposure to Taenia solium in pigs. However, only a limited number of parasites have been evaluated for cross reactivity. Pigs may host other related cestode infections, including Taenia hydatigena, which have not been formally evaluated for cross-reactions. We investigated a corral in Tumbes, Peru, a region where a cysticercosis elimination demonstration project was completed in 2012...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28969835/serological-diagnosis-of-taenia-solium-in-pigs-no-measurable-circulating-antigens-and-antibody-response-following-exposure-to-taenia-saginata-oncospheres
#3
P Dorny, V Dermauw, A Van Hul, C Trevisan, S Gabriël
Taenia solium taeniasis/cysticercosis is a zoonosis included in the WHO's list of neglected tropical diseases. Accurate diagnostic tools for humans and pigs are needed to monitor intervention outcomes. Currently used diagnostic tools for porcine cysticercosis all have drawbacks. Serological tests are mainly confronted with problems of specificity. More specifically, circulating antigen detecting tests cross-react with Taenia hydatigena and the possibility of transient antigens as a result of aborted infections is suspected...
October 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28929396/prevalence-of-echinococcus-granulosus-taeniasis-in-stray-dogs-in-the-region-of-constantine-north-east-algeria
#4
K Kohil, M C Benchikh El Fegoun, M Gharbi
In North Africa, the domestic dog is regarded as the main reservoir for infection by Echinococcus granulosus of domestic livestock and man. In Algeria, there is very little data on the rate of infestation of dogs, while the prevalence of E. granulosus in the definitive host is a very reliable marker of the potential risk of transmission of cystic tapeworm to humans and livestock. To find out this information, a survey was conducted to assess the prevalence of infection with E. granulosus in stray dogs in the region of Constantine (North-East Algeria)...
October 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28892472/target-product-profiles-for-the-diagnosis-of-taenia-solium-taeniasis-neurocysticercosis-and-porcine-cysticercosis
#5
Meritxell Donadeu, Anna S Fahrion, Piero L Olliaro, Bernadette Abela-Ridder
Target Product Profiles (TPPs) are process tools providing product requirements to guide researchers, developers and manufacturers in their efforts to develop effective and useful products such as biologicals, drugs or diagnostics. During a WHO Stakeholders Meeting on Taenia solium diagnostics, several TPPs were initiated to address diagnostic needs for different stages in the parasite's transmission (taeniasis, human and porcine cysticercosis). Following the meeting, draft TPPs were completed and distributed for consultation to 100 people/organizations, including experts in parasitology, human and pig cysticercosis, diagnostic researchers and manufacturers, international organizations working with neglected or zoonotic diseases, Ministries of Health and Ministries of Livestock in some of the endemic countries, WHO regional offices and other interested parties...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28764162/taeniasis-an-unusual-presentation
#6
Shobha Prasada, Sevitha Bhat, K Vidyalakshmi
We report a case of 45-year-old male presenting with the history of nasal expulsion of segments of Taenia saginata. This route of expulsion is a rare occurrence. The report stresses this unusual presentation of taeniasis in endemic region.
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28749758/identifying-helminth-infections-via-routine-fecal-parasitological-examinations-in-korea
#7
Seung Ho Choi, Changhyun Lee, Jong In Yang, Min-Sun Kwak, Goh Eun Chung, Hae Yeon Kang, Su Jin Chung, Jeong Yoon Yim, Joo Sung Kim
We conducted this study to explore the extent of occult helminth infection identified by fecal parasitological examinations or organ-specific examinations such as colonoscopy and abdominal ultrasonography (US) during health checkups. We analyzed 197,422 fecal samples from 99,451 subjects who received health checkups at a single center over 10 years. We found that 3,472 (1.8%) samples from 3,342 (3.4%) subjects tested positive for parasitic ova, including clonorchiasis, metagonimiasis, trichuriasis, ascariasis, trichostrongylosis, taeniasis, and enterobiasis...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28686662/comparison-of-a-new-multiplex-real-time-pcr-with-the-kato-katz-thick-smear-and-copro-antigen-elisa-for-the-detection-and-differentiation-of-taenia-spp-in-human-stools
#8
COMPARATIVE STUDY
Dinh Ng-Nguyen, Mark A Stevenson, Pierre Dorny, Sarah Gabriël, Tinh Van Vo, Van-Anh Thi Nguyen, Trong Van Phan, Sze Fui Hii, Rebecca J Traub
BACKGROUND: Taenia solium, the cause of neurocysticercosis (NCC), has significant socioeconomic impacts on communities in developing countries. This disease, along with taeniasis is estimated to infect 2.5 to 5 million people globally. Control of T. solium NCC necessitates accurate diagnosis and treatment of T. solium taeniasis carriers. In areas where all three species of Taenia tapeworms (T. solium, Taenia saginata and Taenia asiatica) occur sympatrically, conventional microscope- and copro-antigen based diagnostic methods are unable to distinguish between these three Taenia species...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28634145/taeniasis-caused-by-taenia-saginata-in-gianyar-town-and-taenia-solium-in-karangasem-villages-of-bali-indonesia-2011-2016-how-to-detect-tapeworm-carriers-anamnesis-or-microscopy
#9
Kadek Swastika, Toni Wandra, Nyoman Sadra Dharmawan, I Made Sudarmaja, John Master Saragih, Luh Putu Eka Diarthini, Luh Ariwati, Putu Ayu Asri Damayanti, Dewa Ayu Agus Sri Laksemi, Nengah Kapti, Putu Sutisna, Tetsuya Yanagida, Akira Ito
From January 2011 until September 2016, screening of taeniasis carriers was carried out in a town in Gianyar District (Taenia saginata) and in villages which consisted of several Banjars (the smallest community units) on the eastern slope of Mt. Agung, Karangasem District (Taenia solium) in Bali, Indonesia. Fecal samples from all community members who chose to participate were examined microscopically for detection of taeniid eggs each person completedwith a questionnaire to determine if they had seen whitish, noodle-like proglottids (anamnesis) in their feces...
June 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28615981/human-taeniasis-current-insights-into-prevention-and-management-strategies-in-endemic-countries
#10
REVIEW
Anna L Okello, Lian Francesca Thomas
Human taeniasis is a zoonotic condition resulting from infection with the adult stages of Taenia saginata ("beef tapeworm"), Taenia solium ("pork tapeworm") or Taenia asiatica ("Asian tapeworm"). Although these parasites have a worldwide distribution, the overwhelming burden is felt by communities in low- and middle-income countries. This is particularly true for T. solium, whereby infection of the central nervous system with the larval stage of the parasite (neurocysticercosis) is a major cause of acquired epilepsy in low-resource settings...
2017: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/28569208/development-of-a-health-education-intervention-strategy-using-an-implementation-research-method-to-control-taeniasis-and-cysticercosis-in-burkina-faso
#11
Helena Ngowi, Ivan Ozbolt, Athanase Millogo, Veronique Dermauw, Télesphore Somé, Paul Spicer, Lori L Jervis, Rasmané Ganaba, Sarah Gabriel, Pierre Dorny, Hélène Carabin
BACKGROUND: Taeniasis and cysticercosis are two diseases caused by Taenia solium, a parasite transmitted between humans and pigs, leading to considerable economic loss and disabilities. Transmission of the parasite is linked to environmental and behavioural factors such as inadequate sanitation and hygiene, poor pig management, and consumption of infected pork. This study used implementation research method to design a health education intervention strategy for reducing T. solium infections in Burkina Faso, a country endemic for the parasite...
June 1, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28449318/screening-diagnosis-and-management-of-human-cysticercosis-and-taenia-solium-taeniasis-technical-recommendations-by-the-cohemi-project-study-group
#12
Lorenzo Zammarchi, Maurizio Bonati, Marianne Strohmeyer, Marco Albonico, Ana Requena-Méndez, Zeno Bisoffi, Alessandra Nicoletti, Hector H García, Alessandro Bartoloni
Neurocysticercosis, the central nervous system's localised form of cysticercosis, is considered to be the leading cause of epilepsy in the developing world. In Europe, the disease is mainly imported and affects both immigrants and travellers. However, autochthonous cases of cysticercosis in low-endemic countries could also originate from Taenia solium carriers (migrants or travellers) who acquired taeniasis overseas. Management of cysticercosis is a challenge for European healthcare providers as they are often hardly aware of this infection and have little familiarity in managing this disease...
July 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28435310/tropical-diseases-of-the-myocardium-a-review
#13
REVIEW
Zoe C Groom, Aristotle D Protopapas, Vasileios Zochios
Cardiovascular diseases are widely distributed throughout the world. Human parasitic infections are ubiquitous. Tropical parasites are increasingly recognized as causes of cardiovascular diseases. In this review, we address the most frequently reported parasites that directly infect the myocardium, including Trypanosoma cruzi, the protozoal causative agent of American trypanosomiasis (Chagas disease), and Taenia solium, the cestode causative agent of taeniasis and cysticercosis. We also discuss tropical endomyocardial fibrosis, trichinellosis and schistosomiasis...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28406898/spatial-relationship-between-taenia-solium-tapeworm-carriers-and-necropsy-cyst-burden-in-pigs
#14
Ian W Pray, Viterbo Ayvar, Ricardo Gamboa, Claudio Muro, Luz M Moyano, Victor Benavides, Robert H Flecker, Hector H Garcia, Seth E O'Neal
BACKGROUND: Taenia solium, a parasite that affects humans and pigs, is the leading cause of preventable epilepsy in the developing world. Geographic hotspots of pigs testing positive for serologic markers of T. solium exposure have been observed surrounding the locations of human tapeworm carriers. This clustered pattern of seropositivity in endemic areas formed the basis for geographically targeted control interventions, which have been effective at reducing transmission. In this study, we further explore the spatial relationship between human tapeworm carriers and infected pigs using necroscopic examination as a quantitative gold-standard diagnostic to detect viable T...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28336269/epidemiology-of-polyparasitism-with-taenia-solium-schistosomes-and-soil-transmitted-helminths-in-the-co-endemic-village-of-malanga-democratic-republic-of-congo
#15
Joule Madinga, Katja Polman, Kirezi Kanobana, Lisette van Lieshout, Eric Brienen, Nicolas Praet, Constantin Kabwe, Sarah Gabriël, Pierre Dorny, Pascal Lutumba, Niko Speybroeck
Helminth co-infections are common in sub-Saharan Africa. However, little is known about the distribution and determinants of co-infections with Taenia solium taeniasis/cysticercosis. Building on a previous community-based study on human cysticercosis in Malanga village, we investigated co-infections with Taenia solium, soil-transmitted helminths (STHs) and Schistosoma spp and associated risk factors in a random subsample of 330 participants. Real time PCR assays were used to detect DNA of soil-transmitted helminths (STHs), T...
March 20, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28320455/a-systematic-review-of-taeniasis-cysticercosis-and-trichinellosis-in-vietnam
#16
REVIEW
Dinh Ng-Nguyen, Mark A Stevenson, Rebecca J Traub
Taeniasis, cysticercosis and trichinellosis have been ranked as the most important food-borne parasites of humans in terms of public health, socioeconomic and trade impact. Despite this, information on these food-borne zoonoses in Vietnam is scarce and fragmented, and many local reports remain inaccessible to the international research community. This study aims to conduct comprehensive literature searches to report on the incidence and estimate the true prevalence of taeniasis in humans and T. solium cysticercosis in humans and pigs in Vietnam utilizing Bayesian models; in addition, to report the incidence and the distribution of trichinellosis...
March 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28289849/geo-helminthiasis-among-migrants-in-sicily-a-possible-focus-for-re-emerging-neurocysticercosis-in-europe
#17
Ildebrando Patamia, Piermario Nicotra, Davide Amodeo, Loretta Giuliano, Calogero Edoardo Cicero, Alessandra Nicoletti
A dramatic increasing immigration flow was recorded in Europe during the last years. Only in Sicily 120,239 people arrived in 2014. Immigrants may carry neglected tropical diseases endemic in their origin countries. The aim of our study was to evaluate the frequency of geo-helminthiasis, and in particular of intestinal taeniasis, in a sample of migrants hosted in a large asylum seeker centre in the province of Catania. A stool sample was obtained from all the enrolled subjects and a coproparasitological examination was performed...
June 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28251230/parasitic-infestation-in-appendicitis-a-retrospective-analysis-of-660-patients-and-brief-literature-review
#18
REVIEW
Eren Altun, Veli Avci, Meltem Azatcam
To investigate the incidence of parasitic infestations and inflammation accompanying parasitosis in a series of appendectomy cases.  Methods: Six-hundred-sixty  patients who had undergone appendectomy in Bingöl State Hospital, Bingol, Turkey with the preliminary diagnosis of appendicitis between January 2012 and February 2015 were included in this retrospective study. They were retrospectively evaluated in terms of age, gender and pathological findings. Cases diagnosed with parasitic infestations were re-evaluated histopathologically for inflammatory response...
March 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28183336/assessing-the-impact-of-intervention-strategies-against-taenia-solium-cysticercosis-using-the-epicyst-transmission-model
#19
Peter Winskill, Wendy E Harrison, Michael D French, Matthew A Dixon, Bernadette Abela-Ridder, María-Gloria Basáñez
BACKGROUND: The pork tapeworm, Taenia solium, and associated human infections, taeniasis, cysticercosis and neurocysticercosis, are serious public health problems, especially in developing countries. The World Health Organization (WHO) has set goals for having a validated strategy for control and elimination of T. solium taeniasis/cysticercosis by 2015 and interventions scaled-up in selected countries by 2020. Timely achievement of these internationally-endorsed targets requires that the relative benefits and effectiveness of potential interventions be explored rigorously within a quantitative framework...
February 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28139530/neurocysticercosis-diagnostic-problems-current-therapeutic-strategies
#20
REVIEW
Vedantam Rajshekhar
Neurocysticercosis (NCC) is the most common single cause of seizures/epilepsy in India and several other endemic countries throughout the world. It is also the most common parasitic disease of the brain caused by the cestode Taenia solium or pork tapeworm. The diagnosis of NCC and the tapeworm carrier (taeniasis) can be relatively inaccessible and expensive for most of the patients. In spite of the introduction of several new immunological tests, neuroimaging remains the main diagnostic test for NCC. The treatment of NCC is also mired in controversy although, there is emerging evidence that albendazole (a cysticidal drug) may be beneficial for patients by reducing the number of seizures and hastening the resolution of live cysts...
September 2016: Indian Journal of Medical Research
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