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Cerebral stroke

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https://www.readbyqxmd.com/read/29924461/short-term-external-counterpulsation-augments-cerebral-blood-flow-and-tissue-oxygenation-in-chronic-cerebrovascular-occlusive-disease
#1
Eva E Buschmann, Philipp Hillmeister, Anja Bondke Persson, David S Liebeskind, Lea Schlich, Robert Kamenzky, Andreas Busjahn, Ivo R Buschmann, Peter Bramlage, Andreas Hetzel, Matthias Reinhard
BACKGROUND: External counterpulsation improves cerebral perfusion velocity in acute stroke and may stimulate collateral artery growth. However, whether (non-acute) at-risk patients with high-grade carotid artery disease may benefit from counterpulsation needs to be validated. METHODS: Twenty-eight patients (71±6.5 years, 5 women) with asymptomatic unilateral chronic severe ICA stenosis (>70%) or occlusion were randomized to receive 20 min active counterpulsation followed by sham treatment or vice versa...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29922535/exploring-the-difference-in-post-procedural-stroke-rates-between-patients-with-aortic-stenosis-who-undergo-transcatheter-aortic-valve-replacement-versus-surgical-aortic-valve-replacement
#2
REVIEW
Heather Burke, Agnieszka Boron, Jung-Hyun Lee, Kudrit Riana Kahlon
Transcatheter aortic valve replacement (TAVR) is a newer alternative to surgical aortic valve replacement (SAVR) for patients with severe aortic stenosis. Clinical trials have investigated TAVR's safety and effectiveness. Cerebral embolization is a common complication leading to stroke after TAVR and SAVR; different cerebral protection methods have been studied to prevent this. This paper evaluates the rate of post-procedural stroke rates between TAVR and SAVR and investigates the effect of cerebral protective methods on the stroke risk post-TAVR...
April 17, 2018: Curēus
https://www.readbyqxmd.com/read/29922403/the-epidemiology-of-reversible-cerebral-vasoconstriction-syndrome-in-patients-at-a-colorado-comprehensive-stroke-center
#3
Judd Jensen, Jan Leonard, Kristin Salottolo, Kathryn McCarthy, Jeffrey Wagner, David Bar-Or
Objective: Vasoactive substances, including marijuana, are known precipitating factors of reversible cerebral vasoconstriction syndrome (RCVS). Our objective was to describe the demographics, suspected etiology, and outcomes of RCVS patients, with specific interest in examining the subset of patients who used marijuana prior to the onset of RCVS. Methods: We identified and described consecutive RCVS cases treated at a regional, high-volume Comprehensive Stroke Center in Colorado (2012-2015)...
June 2018: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29922355/ischaemic-haemorrhagic-stroke-in-a-child-with-new-onset-type-1-diabetes-mellitus
#4
Noor Shafina Mohd Nor, Choong Yi Fong, Kartini Rahmat, Wan Mun Vanessa Lee, Azriyanti Anuar Zaini, Muhammad Yazid Jalaludin
Cerebral oedema is the most common neurological complication of diabetic ketoacidosis (DKA). However, ischaemic and haemorrhagic brain injury has been reported infrequently. A 10-year old girl who was previously well presented with severe DKA. She was tachycardic with poor peripheral perfusion but normotensive. However, two fast boluses totalling 40 ml/kg normal saline were given. She was transferred to another hospital where she was intubated due to drowsiness. Rehydration fluid (maintenance and 48-hour correction for 7...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29921716/acute-complement-inhibition-potentiates-neurorehabilitation-and-enhances-tpa-mediated-neuroprotection
#5
Ali Alawieh, Meredith Andersen, DeAnna L Adkins, Stephen Tomlinson
Since complement activation in the subacute or chronic phase after stroke was recently shown to stimulate neural plasticity, we investigated how complement activation and complement inhibition in the acute phase after murine stroke interacts with subsequent rehabilitation therapy to modulate neuroinflammation and neural remodeling. We additionally investigated how complement and complement inhibition interacts with tissue plasminogen activator (tPA), the other standard of care therapy for stroke, and an FDA preclinical requirement for translation of an experimental stroke therapy...
June 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29921486/comparison-of-magnetic-resonance-spectroscopy-mrs-with-arterial-spin-labeling-asl-in-the-differentiation-between-mitochondrial-encephalomyopathy-lactic-acidosis-plus-stroke-like-episodes-melas-and-acute-ischemic-stroke-ais
#6
Xiaodi Li, Yuzhou Wang, Zhanhang Wang, Jianjun Lu, Yan Xu, Jinlong Ye, Zuying Kuang, Bo Li, Mengqiu Pan, Wenming Chen, Shuisheng Lu, Ziyang Zhou, Lina Cheng, Honghao Wang
To compare the utility and limitation of magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS), a retrospective review of 17 MELAS and 26 AIS patients were performed. In all patients both MRS and ASL scans were performed within 1 week after admission. Demographic, clinical, laboratory and MR imaging data were reviewed and compared between the two groups...
June 16, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29920296/a-new-method-for-correcting-middle-cerebral-artery-flow-velocity-for-age-by-calculating-z-scores
#7
A Schaafsma
BACKGROUND: For the interpretation of middle cerebral artery flow velocity (MCAFV) measurements by transcranial Doppler clinicians should take normal aging into account. NEW METHOD: MCAFV measurements can be corrected for age by a transformation to Z-scores, expressing in standard deviations the distance of a measurement to the regression line as function of age. Zscores for different parameters can be combined into a single plot in order to facilitate clinical interpretation...
June 16, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29917203/mirna-26a-promotes-angiogenesis-in-a-rat-model-of-cerebral-infarction-via-pi3k-akt-and-mapk-erk-pathway
#8
Z Liang, Y-J Chi, G-Q Lin, S-H Luo, Q-Y Jiang, Y-K Chen
OBJECTIVE: To investigate the specific role of microRNA-26 (miRNA-26a) in a rat model of cerebral ischemic stroke and the underlying mechanism. MATERIALS AND METHODS: A rat model of middle cerebral artery occlusion (MCAO) was established to induce permanent cerebral infarction. Neuro-behavior was observed and scored after model establishment. The expression of miRNA-26a in brain tissue and brain microvascular endothelial cells (BMECs) of rats after cerebral ischemic stroke was detected by quantitative polymerase chain reaction (qPCR)...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916544/yc%C3%A2-1-reduces-inflammatory-responses-by-inhibiting-nuclear-factor%C3%A2-%C3%AE%C2%BAb-translocation-in-mice-subjected-to-transient-focal-cerebral-ischemia
#9
Wei-Ting Lee, Shih-Huang Tai, Yu-Wen Lin, Tian-Shung Wu, E-Jian Lee
3‑(5‑hydroxymethyl‑2‑furyl)‑1‑benzyl‑indazole (YC‑1) is understood to protect against ischemic stroke, but the molecular basis for its neuroprotection remains to be fully characterized. The present study investigated the influence of YC‑1 on inflammatory responses following experimental stroke. Previous studies indicated that nuclear factor (NF)‑κB‑driven signals serve a pivotal role in mediating inflammatory responses following stroke. Ischemic stroke results in activation of NF‑κB to induce gene expression of factors including inducible nitric oxide synthase, interleukin (IL)‑1β, IL‑6 and matrix metalloproteinases (MMPs)...
June 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29916125/contribution-of-apelin-17-to-collateral-circulation-following-cerebral-ischemic-stroke
#10
Wan Jiang, Wei Hu, Li Ye, Yanghua Tian, Ren Zhao, Juan Du, Bing Shen, Kai Wang
Apelin, an essential mediator of homeostasis, is crucially involved in cardiovascular diseases, including ischemic stroke. However, the functional roles of apelin-17 in cerebral collateral circulation and ischemic stroke protection are unknown. Here, we investigated the association between plasma apelin-17 levels and collateral circulation in patients with ischemic stroke and examined the mechanism undergirding the effects of apelin-17 on cerebral artery contraction and ischemic stroke protection in an animal model...
June 18, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29915811/related-factors-of-early-mortality-in-young-adults-with-cerebral-hemorrhage
#11
Hong Xia Zhou, Nina Hao, Xiao Lin Xu
Background: The main causes of intracerebral hemorrhage differ between young adults and older adults. Data regarding potential targets for early intervention in young adult patients with intracerebral hemorrhage are lacking. Methods: We retrospectively analysed data for 196 young adult patients with intracerebral hemorrhage who were admitted to Tianjin Huanhu Hospital and died within 30 days of admission between June 2005 and June 2015. The Kaplan-Meier method was used to calculate survival rate, and the log-rank test was used to determine survival rate significance...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29915767/a-novel-surgical-correction-and-innovative-splint-for-swan-neck-deformity-in-hypermobility-syndrome
#12
Karthik Vishwanathan, Deepak Ganjiwale
Splinting is a great domain of occupational therapy profession. Making a splint for the patient would depend on the need or requirement of the problems and deformities. Swan neck deformity is an uncommon condition, and it can be seen in rheumatoid arthritis, cerebral palsy, and after trauma. Conservative treatment of the swan neck deformity is available by different static splints only. There are very few reports of surgical correction of swan-neck deformity in benign hypermobility syndrome. This case report describes the result of novel surgical intervention and an innovative hand splint in a 20-year-old female with a history of cardiovascular stroke with no residual neurological deficit...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915125/beyond-large-vessel-occlusion-strokes-distal-occlusion-thrombectomy
#13
Jonathan A Grossberg, Leticia C Rebello, Diogo C Haussen, Mehdi Bouslama, Meredith Bowen, Clara M Barreira, Samir R Belagaje, Michael R Frankel, Raul G Nogueira
BACKGROUND AND PURPOSE: Endovascular therapy is the standard of care for the treatment of proximal large vessel occlusion strokes. Its safety and efficacy in the treatment of distal intracranial occlusions has not been well studied. METHODS: The data that support the findings of this study are available from the corresponding author on reasonable request. Retrospective review of a prospectively collected endovascular database (2010-2015, n=949) for all patients with distal intracranial occlusions treated endovascularly...
June 18, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29915123/efficacy-and-safety-of-ticagrelor-in-relation-to-aspirin-use-within-the-week-before-randomization-in-the-socrates-trial
#14
K S Lawrence Wong, Pierre Amarenco, Gregory W Albers, Hans Denison, J Donald Easton, Scott R Evans, Peter Held, Anders Himmelmann, Scott E Kasner, Mikael Knutsson, Per Ladenvall, Kazuo Minematsu, Carlos A Molina, Yongjun Wang, S Claiborne Johnston
BACKGROUND AND PURPOSE: SOCRATES (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), comparing ticagrelor with aspirin in patients with acute cerebral ischemia, found a nonsignificant 11% relative risk reduction for stroke, myocardial infarction, or death ( P =0.07). Aspirin intake before randomization could enhance the effect of ticagrelor by conferring dual antiplatelet effect during a high-risk period for subsequent stroke. Therefore, we explored the efficacy and safety of ticagrelor versus aspirin in the patients who received any aspirin the week before randomization...
June 18, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29914832/quantification-of-aortic-shagginess-as-a-predictive-factor-of-perioperative-stroke-and-long-term-prognosis-after-endovascular-treatment-of-aortic-arch-disease
#15
Akihiro Hosaka, Manabu Motoki, Masaaki Kato, Hiroko Sugai, Nobukazu Okubo
OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) with supra-aortic debranching has recently been introduced as a treatment option for aortic arch disease. Although less invasive than open repair, TEVAR is associated with a risk of perioperative embolic stroke due to dislodgment of atherosclerotic plaque debris, especially in individuals with atheromatous degeneration of the aortic lumen. It is difficult to determine atheroma vulnerability, and there is no current method for predicting the risk of atheroembolism...
June 15, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29913521/comparison-of-efficacy-embolism-rate-and-safety-of-thrombectomy-with-stent-retrievers-in-an-anterior-circulation-stroke-model
#16
Naomi Larsen, Katharina Oberbeck, Rodrigo Lima de Miranda, Jens Trentmann, Jawid Madjidyar, Eckhard Quandt, Olav Jansen
PURPOSE:  Various stent retrievers differing in stent design and mechanical properties are currently available for the treatment of ischemic stroke. We conducted this in vitro study to compare the efficacy, embolism rate, and safety of commercially available stent retrievers and prototypes. MATERIALS AND METHODS:  Whole blood thrombi were produced in a Chandler loop. The thrombi were inserted into the curved M1 segment of a silicone model of the anterior cerebral circulation...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913294/association-between-champagne-bottle-neck-sign-of-internal-carotid-artery-and-ipsilateral-hemorrhagic-stroke-in-patients-with-moyamoya-disease
#17
Jian Wang, Gong Chen, Yongbo Yang, Bing Zhang, Zhongzhi Jia, Peiyuan Gu, Dong Wei, Jing Ji, Weixing Hu, Xihai Zhao
OBJECTIVE: To assess the association between champagne bottle neck sign (CBNS) in carotid artery and intracranial hemorrhage in patients with moyamoya disease (MMD). METHODS: From January 2016 to December 2017, a total of 76 consecutive patients with MMD without definite risk factors associated intracranial hemorrhage who underwent preoperative angiography were included in this retrospective study. CBNS was defined as luminal diameter of internal carotid artery (ICA)/common carotid artery (CCA) ≤ 0...
June 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29910175/tlr4-binding-dna-aptamers-show-a-protective-effect-against-acute-stroke-in-animal-models
#18
Gerónimo Fernández, Ana Moraga, María I Cuartero, Alicia García-Culebras, Carolina Peña-Martínez, Jesús M Pradillo, Macarena Hernández-Jiménez, Silvia Sacristán, M Irene Ayuso, Rafael Gonzalo-Gobernado, David Fernández-López, M Elena Martín, María A Moro, Victor M González, Ignacio Lizasoain
Since Toll-like receptor 4 (TLR4) mediates brain damage after stroke, development of TLR4 antagonists is a promising therapeutic strategy for this disease. Our aim was to generate TLR4-blocking DNA aptamers to be used for stroke treatment. From a random oligonucleotide pool, we identified two aptamers (ApTLR#1R, ApTLR#4F) with high affinity for human TLR4 by systematic evolution of ligands by exponential enrichment (SELEX). Optimized truncated forms (ApTLR#1RT, ApTLR#4FT) were obtained. Our data demonstrate specific binding of both aptamers to human TLR4 as well as a TLR4 antagonistic effect...
June 15, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29909774/cardiovascular-magnetic-resonance-assessment-of-acute-cardiovascular-effects-of-voluntary-apnoea-in-elite-divers
#19
L Eichhorn, J Doerner, J A Luetkens, J M Lunkenheimer, R C Dolscheid-Pommerich, F Erdfelder, R Fimmers, J Nadal, B Stoffel-Wagner, H H Schild, A Hoeft, B Zur, C P Naehle
BACKGROUND: Prolonged breath holding results in hypoxemia and hypercapnia. Compensatory mechanisms help maintain adequate oxygen supply to hypoxia sensitive organs, but burden the cardiovascular system. The aim was to investigate human compensatory mechanisms and their effects on the cardiovascular system with regard to cardiac function and morphology, blood flow redistribution, serum biomarkers of the adrenergic system and myocardial injury markers following prolonged apnoea. METHODS: Seventeen elite apnoea divers performed maximal breath-hold during cardiovascular magnetic resonance imaging (CMR)...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29909652/improvement-in-overactive-bladder-symptoms-in-patients-using-functional-electrical-stimulation-of-the-common-peroneal-nerve-for-walking
#20
Nicola Hare, Petros Georgopoulos, Kate E Philips, Joanne E Johnson, Coralie Seary, Jalesh N Panicker, Valerie L Stevenson
OBJECTIVE: Functional electrical stimulation is used to improve walking speed and reduces falls in people with upper motor neurone foot-drop. Following anecdotal observations of changes in bladder symptoms, an observational study was performed to explore this association further. DESIGN: A total of 47 consecutive patients attending for setup with functional electrical stimulation during a six-month period were asked to complete a questionnaire assessing bladder symptoms (ICIQ-OAB (International Consultation on Incontinence Questionnaire Overactive Bladder)) at baseline and three  months during routine appointments...
June 1, 2018: Clinical Rehabilitation
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