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https://www.readbyqxmd.com/read/28655215/development-of-a-new-method-based-on-unmodified-gold-nanoparticles-and-peptide-nucleic-acids-for-detecting-bovine-viral-diarrhea-virus-rna
#1
Maryam Askaravi, Seyedeh Elham Rezatofighi, Saadat Rastegarzadeh, Masoud Reza Seifi Abad Shapouri
A simple colorimetric assay is presented for detecting bovine viral diarrhea virus (BVDV)-RNA based on aggregation of gold nanoparticles (AuNPs) in the presence of charge-neutral peptide nucleic acids (PNA). Free charge-neutral PNA oligomers tended to be adsorbed onto AuNPs and act as a coagulant, whereas hybridizing complementary RNA with PNA disrupted PNA-induced AuNP aggregation, and the NPs remained stable. However, non-complementary RNA did not have this effect, and PNA induced aggregation of the AuNPs that resulted in a color change of the reaction from red to blue...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28655167/identification-of-transcript-regulatory-patterns-in-cell-differentiation
#2
Arief Gusnanto, John Paul Gosling, Christopher Pope
Motivation: Studying transcript regulatory patterns in cell differentiation is critical in understanding its complex nature of the formation and function of different cell types. This is done usually by measuring gene expression at different stages of the cell differentiation. However, if the gene expression data available are only from the mature cells, we have some challenges in identifying transcript regulatory patterns that govern the cell differentiation. Results: We propose to exploit the information of the lineage of cell differentiation in terms of correlation structure between cell types...
June 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28654963/visualizing-fmri-bold-responses-to-diverse-naturalistic-scenes-using-retinotopic-projection
#3
Karl Zipser
To view brain activity in register with visual stimuli, a technique here referred to as "retinotopic projection," which translates functional measurements into retinotopic space, is employed. Retinotopic projection is here first applied to a previously acquired fMRI dataset in which a large set of grayscale photos of real scenes were presented to three subjects. A simple model of local contrast integration accounts for much of the data in early visual areas (V1 and V2). However, consistent discrepancies were discovered: Human faces tend to evoke stronger responses relative to other scene elements than predicted by the model, whereas periodic patterns evoke weaker responses than predicted by the model...
June 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28654909/brain-metastases-in-patients-with-non-small-cell-lung-cancer-the-role-of-mutated-egfrs-with-an-exon-19-deletion-or-l858r-point-mutation-in-cancer-cell-dissemination
#4
Shih-Hsin Hsiao, Yu-Ting Chou, Sey-En Lin, Ru-Chun Hsu, Chi-Li Chung, Yu-Rung Kao, H Eugene Liu, Cheng-Wen Wu
Non-small cell lung cancer (NSCLC) patients tend to develop brain metastases (BM), but the link between BM occurrence and driver mutations in NSCLC is not very clear. We explored whether activating mutations of epidermal growth factor receptors (EGFRs) in exon 19 deletion or L858R predict BM in NSCLC. A retrospective multivariable logistic regression analysis of 384 patients demonstrated that the presence of mutated-EGFRs was associated with overall BM (OR=2.24, P=0.001) compared to that of wild-type EGFR (WT-EGFR)...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654799/neurobehavioral-consequences-of-continuous-spike-and-waves-during-slow-sleep-csws-in-a-pediatric-population-a-pattern-of-developmental-hindrance
#5
Valentina De Giorgis, Melissa Filippini, Joyce Ann Macasaet, Silvia Masnada, Pierangelo Veggiotti
INTRODUCTION: Continuous spike and waves during slow sleep (CSWS) is a typical EEG pattern defined as diffuse, bilateral and recently also unilateral or focal localization spike-wave occurring in slow sleep or non-rapid eye movement sleep. Literature results so far point out a progressive deterioration and decline of intellectual functioning in CSWS patients, i.e. a loss of previously normally acquired skills, as well as persistent neurobehavioral disorders, beyond seizure and EEG control...
June 24, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28654792/age-related-plantar-centre-of-pressure-trajectory-changes-during-barefoot-walking
#6
Gisela Sole, Todd Pataky, Christopher C Sole, Leigh Hale, Stephan Milosavljevic
Plantar centre of pressure (COP) variables during gait have been used to predict risk of injury, or consequences thereof. The aim of this study was to determine the effect of age on the COP trajectory during barefoot gait at a self-selected speed. 287 participants (aged 18-80year, 163 women) walked barefoot at self-selected speed across a Footscan(®) force platform, completing five trials for each side. COP trajectories were extracted and trajectory-level canonical correlation analysis was used to test their correlation with age...
June 21, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28654717/similar-reliability-and-equivalent-performance-of-female-and-male-mice-in-the-open-field-and-water-maze-place-navigation-task
#7
Ann-Kristina Fritz, Irmgard Amrein, David P Wolfer
Although most nervous system diseases affect women and men differentially, most behavioral studies using mouse models do not include subjects of both sexes. Many researchers worry that data of female mice may be unreliable due to the estrous cycle. Here, we retrospectively evaluated sex effects on coefficient of variation (CV) in 5,311 mice which had performed the same place navigation protocol in the water-maze and in 4,554 mice tested in the same open field arena. Confidence intervals for Cohen's d as measure of effect size were computed and tested for equivalence with 0...
June 27, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28654570/fear-and-risk-of-falling-activities-of-daily-living-and-quality-of-life-assessment-when-older-adults-receive-emergency-department-care
#8
Tuğba Çinarli, Zeliha Koç
BACKGROUND: Falls tend to create fear and concern in older adults who also seek care in emergency departments (EDs) at high rates. AIM: The purposes of this study were to (a) describe risk and fear of falling in older adults seeking care in the ED and (b) explore relationships between risk and fear of falling with activities of daily living and quality of life. METHODS: The study was conducted in the ED of Ondokuz Mayis University Hospital in Samsun, Turkey...
July 2017: Nursing Research
https://www.readbyqxmd.com/read/28654210/do-plant-eating-insect-lineages-pass-through-phases-of-host-use-generalism-during-speciation-and-host-switching-phylogenetic-evidence
#9
Nate B Hardy
The Oscillation Hypothesis posits that plant-eating insect diversity is generated by cycles of diet breadth expansion and contraction. Although at any given time most plant-eating insect species are host specialists, host use evolution and speciation tend to entail a phase of generalism. The main evidence for this comes from comparative phylogenetic studies, but with mixed support. Here, I review and add to this evidence. I show that some of the original work that inspired the Oscillation Hypothesis is flawed in a way that leads to spurious inferences about trends in the evolution of diet diversity...
June 27, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28653821/effects-of-aca-medicaid-expansions-on-health-insurance-coverage-and-labor-supply
#10
Robert Kaestner, Bowen Garrett, Jiajia Chen, Anuj Gangopadhyaya, Caitlyn Fleming
We examined the effect of the expansion of Medicaid eligibility under the Affordable Care Act on health insurance coverage and labor supply of low-educated and low-income adults. We found that the Medicaid expansions were associated with large increases in Medicaid coverage, for example, 50 percent among childless adults, and corresponding decreases in the proportion uninsured. There was relatively little change in private insurance coverage, although the expansions tended to decrease such coverage slightly...
2017: Journal of Policy Analysis and Management
https://www.readbyqxmd.com/read/28653795/reduced-energy-density-of-close-up-diets-decrease-ruminal-ph-and-increase-concentration-of-volatile-fatty-acids-postpartum-in-holstein-cows
#11
Wenming Huang, Yujia Tian, Shengli Li, Zhaohai Wu, Zhijun Cao
The objective of this study was to determine the effect of reduced energy density of close-up diets on ruminal fermentation parameters in transition cows. Fourteen Holstein dry cows were blocked and assigned randomly to three groups fed a high energy density diet (HD, 1.62 Mcal of net energy for lactation (NEL )/kg dry matter (DM)), or a middle energy density diet (MD, 1.47 Mcal NEL /kg DM), or a low energy density diet (LD, 1.30 Mcal NEL /kg DM) prepartum, and were fed the same diet postpartum. The reduced energy density diets decreased the average dry matter intake (DMI) prepartum and tended to increase the DMI postpartum...
June 27, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28653674/effects-of-orthotic-therapeutic-electrical-stimulation-in-the-treatment-of-patients-with-paresis-associated-with-acute-cervical-spinal-cord-injury-a-randomized-control-trial
#12
K Iwahashi, T Hayashi, R Watanabe, A Nishimura, T Ueta, T Maeda, K Shiba
STUDY DESIGN: A randomized controlled trial. OBJECTIVES: To determine the effects of orthotic therapeutic electrical stimulation (TES) on the hand in patients with paresis associated with acute cervical spinal cord injury. SETTING: Spinal Injuries Center, Fukuoka, Japan. METHODS: The study included patients treated for spinal cord injuries (Frankel classification, grades B and C) at our institution within 1 week post injury between May 2011 and December 2014...
June 27, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28653566/educational-inequalities-in-hospital-care-for-mortally-ill-patients-in-norway
#13
Jon Ivar Elstad
AIMS: Health care should be allocated fairly, irrespective of patients' social standing. Previous research suggests that highly educated patients are prioritized in Norwegian hospitals. This study examines this contentious issue by a design which addresses two methodological challenges. Control for differences in medical needs is approximated by analysing patients who died from same causes of death. Area fixed effects are used for avoiding that observed educational inequalities are contaminated by geographical differences...
June 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28653471/experimental-warming-alters-migratory-caribou-forage-quality
#14
Tara J Zamin, Steeve D Côté, Jean-Pierre Tremblay, Paul Grogan
Global declines in caribou and reindeer (Rangifer) populations have drawn attention to the myriad of stressors that these arctic and boreal forest herbivores currently face. Arctic warming has resulted in increased tundra shrub growth and therefore Rangifer forage quantity. However, its effects on forage quality have not yet been addressed although they may be critical to Rangifer body condition and fecundity. We investigated the impact of summer warming on the quality of forage available to the Bathurst caribou herd using experimental greenhouses (n=5) located in mesic birch hummock tundra in the central Canadian Low Arctic...
June 27, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28653413/normalizing-trust-participants-immediately-post-hoc-explanations-of-behaviour-in-milgram-s-obedience-experiments
#15
Matthew M Hollander, Jason Turowetz
We bring an ethnomethodological perspective on language and discourse to a data source crucial for explaining behaviour in social psychologist Stanley Milgram's classic 'obedience' experiments - yet one largely overlooked by the Milgram literature. In hundreds of interviews conducted immediately after each experiment, participants sought to justify their actions, often doing so by normalizing the situation as benign, albeit uncomfortable. Examining 91 archived recordings of these interviews from several experimental conditions, we find four recurrent accounts for continuation, each used more frequently by 'obedient' than 'defiant' participants...
June 26, 2017: British Journal of Social Psychology
https://www.readbyqxmd.com/read/28653301/morphological-assessment-of-the-stylohyoid-complex-variations-with-cone-beam-computed-tomography-in-a-turkish-population
#16
Cansu Buyuk, Kaan Gunduz, Hakan Avsever
BACKGROUND: The aim of this investigation was to evaluate the length, thickness, sagittal and transvers angulations and the morphological variations of the stylohyoid complex (SHC), to assess their probable assosiations with age and gender, and to investigate the prevalence of it in a wide range of a Turkish sub-population by using cone beam computed tomograph (CBCT), thereby conducting dentist and maxillofacial surgeons. METHODS: The CBCT images of the 1000 patients were evaluated retrospectively...
June 27, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28653196/air-pollution-and-hospital-visits-for-acute-upper-and-lower-respiratory-infections-among-children-in-ningbo-china-a-time-series-analysis
#17
Pei-Wen Zheng, Jian-Bing Wang, Zhen-Yu Zhang, Peng Shen, Peng-Fei Chai, Die Li, Ming-Juan Jin, Meng-Ling Tang, Huai-Chu Lu, Hong-Bo Lin, Kun Chen
Acute upper and lower respiratory infections are main causes of mortality and morbidity in children. Air pollution has been recognized as an important contributor to development and exacerbation of respiratory infections. However, few studies are available in China. In this study, we investigated the short-term effect of air pollution on hospital visits for acute upper and lower respiratory infections among children under 15 years in Ningbo, China. Poisson generalized models were used to estimate the associations between air pollution and hospital visits for acute upper and lower respiratory infections adjusted for temporal, seasonal, and meteorological effects...
June 26, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28652925/effect-of-feeding-garlic-leaves-on-rumen-fermentation-methane-emission-plasma-glucose-kinetics-and-nitrogen-utilization-in-sheep
#18
Arvinda Panthee, Ayana Matsuno, Mohammad Al-Mamun, Hiroaki Sano
BACKGROUND: Garlic and its constituents are reported to have been effective in reducing methane emission and also influence glucose metabolism in body; however, studies in ruminants using garlic leaves are scarce. Garlic leaves contain similar compounds as garlic bulbs, but are discarded in field after garlic bulb harvest. We speculate that feeding garlic leaves might show similar effect as garlic constituents in sheep and could be potential animal feed supplement. Thus, we examined the effect of freeze dried garlic leaves (FDGL) on rumen fermentation, methane emission, plasma glucose kinetics and nitrogen utilization in sheep...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/28652867/scattered-genomic-amplification-in-dedifferentiated-liposarcoma
#19
Nils Mandahl, Linda Magnusson, Jenny Nilsson, Björn Viklund, Elsa Arbajian, Fredrik Vult von Steyern, Anders Isaksson, Fredrik Mertens
BACKGROUND: Atypical lipomatous tumor (ALT), well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS) are cytogenetically characterized by near-diploid karyotypes with no or few other aberrations than supernumerary ring or giant marker chromosomes, although DDLS tend to have somewhat more complex rearrangements. In contrast, pleomorphic liposarcomas (PLS) have highly aberrant and heterogeneous karyotypes. The ring and giant marker chromosomes contain discontinuous amplicons, in particular including multiple copies of the target genes CDK4, HMGA2 and MDM2 from 12q, but often also sequences from other chromosomes...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/28652840/social-media-as-an-open-learning-resource-in-medical-education-current-perspectives
#20
REVIEW
S Sutherland, A Jalali
PURPOSE: Numerous studies evaluate the use of social media as an open-learning resource in education, but there is a little published knowledge of empirical evidence that such open-learning resources produce educative outcomes, particularly with regard to student performance. This study undertook a systematic review of the published literature in medical education to determine the state of the evidence as to empirical studies that conduct an evaluation or research regarding social media and open-learning resources...
2017: Advances in Medical Education and Practice
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