keyword
MENU ▼
Read by QxMD icon Read
search

Tend

keyword
https://www.readbyqxmd.com/read/27933712/the-importance-of-mrna-structure-in-determining-the-pathogenicity-of-synonymous-and-non-synonymous-mutations-in-haemophilia
#1
N Hamasaki-Katagiri, B C Lin, J Simon, R C Hunt, T Schiller, E Russek-Cohen, A A Komar, H Bar, C Kimchi-Sarfaty
INTRODUCTION: Mutational analysis is commonly used to support the diagnosis and management of haemophilia. This has allowed for the generation of large mutation databases which provide unparalleled insight into genotype-phenotype relationships. Haemophilia is associated with inversions, deletions, insertions, nonsense and missense mutations. Both synonymous and non-synonymous mutations influence the base pairing of messenger RNA (mRNA), which can alter mRNA structure, cellular half-life and ribosome processivity/elongation...
December 9, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27933258/p-th-moment-and-almost-sure-stability-of-stochastic-switched-nonlinear-systems
#2
Haibo Gu, Caixia Gao
This paper mainly tends to utilize [Formula: see text]-type function to investigate p-th moment and almost sure stability for a class of stochastic switched nonlinear systems. Based on the multiple Lyapunov functions approach, some sufficient conditions are derived to check the stability criteria of stochastic switched nonlinear systems. One numerical example is provided to demonstrate the effectiveness of the proposed results.
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933017/why-acting-environmentally-friendly-feels-good-exploring-the-role-of-self-image
#3
Leonie A Venhoeven, Jan Willem Bolderdijk, Linda Steg
Recent research suggests that engagement in environmentally-friendly behavior can feel good. Current explanations for such a link do not focus on the nature of environmentally-friendly behavior itself, but rather propose well-being is more or less a side-benefit; behaviors that benefit environmental quality (e.g., spending one's money on people rather than products) also tend to make us feel good. We propose that the moral nature of environmentally-friendly behavior itself may elicit positive emotions as well, because engaging in this behavior can signal one is an environmentally-friendly and thus a good person...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932965/the-neural-correlates-of-humor-creativity
#4
Ori Amir, Irving Biederman
Unlike passive humor appreciation, the neural correlates of real-time humor creation have been unexplored. As a case study for creativity, humor generation uniquely affords a reliable assessment of a creative product's quality with a clear and relatively rapid beginning and end, rendering it amenable to neuroimaging that has the potential for reflecting individual differences in expertise. Professional and amateur "improv" comedians and controls viewed New Yorker cartoon drawings while being scanned. For each drawing, they were instructed to generate either a humorous or a mundane caption...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27932788/health-system-productivity-change-in-zambia-a-focus-on-the-child-health-services
#5
Tom Achoki, Yohannes Kinfu, Felix Masiye, Geert W J Frederix, Anke Hovels, Hubert G Leufkens
Efficiency and productivity improvement have become central in global health debates. In this study, we explored productivity change, particularly the contribution of technological progress and efficiency gains associated with improvements in child survival in Zambia (population 15 million). Productivity was measured by applying the Malmquist productivity index on district-level panel data. The effect of socioeconomic factors was further analyzed by applying an ordinary least squares regression technique. During 2004-2009, overall productivity in Zambia increased by 5...
December 8, 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/27932679/tendon-collagen-synthesis-declines-with-immobilization-in-elderly-humans-no-effect-of-anti-inflammatory-medication
#6
Kasper Dideriksen, Anders Ploug Boesen, Søren Reitelseder, Christian Couppe, Rene Brüggebusch Svensson, Peter Schjerling, S Peter Magnusson, Lars Holm, Michael Kjaer
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAID) are used as pain killers during periods of unloading caused by traumatic occurrences or diseases. However, it is unknown how the tendon protein turnover and mechanical properties responds to unloading and subsequent loading in elderly humans, and especially whether NSAIDs affect tendon adaptation during such periods. Thus, we studied the influence of NSAID upon the human patellar tendon protein synthesis and mechanical properties during immobilization and subsequent rehabilitating resistance training...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27931992/the-attitudes-of-primary-healthcare-providers-towards-web-based-training-on-public-health-services-in-rural-china-a-cross-sectional-study
#7
X X Zhan, Z X Zhang, F Sun, W J Peng, H Zhang, W R Yan
OBJECTIVES: To explore the attitudes of primary healthcare workers, including township public health workers (TPHWs) and village doctors (ViDs), towards web-based training on basic public health services (BPHS) and to examine the factors influencing their attitudes. STUDY DESIGN: Cross-sectional study. METHODS: Questionnaires addressing training status, needs, and attitudes towards web-based public health training were administered to 2768 primary healthcare workers from May to September 2013...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931914/schizophrenia-and-depression-the-relation-between-sleep-quality-and-working-memory
#8
Maurits van den Noort, Esli Struys, Benoît Perriard, Heike Staudte, Sujung Yeo, Sabina Lim, Peggy Bosch
Sleep is known to be markedly disturbed in patients with depression, but in patients with schizophrenia these problems are underestimated. This research aimed to determine if a relationship existed between sleep problems in patients with schizophrenia and with depression and their reduced working memory (WM) performance. Thirty outpatients with schizophrenia, 30 outpatients with depression, and 30 healthy control participants were enrolled in this study. All participants completed a sleep questionnaire (i.e...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931743/a-longitudinal-study-of-emotion-regulation-among-sexually-abused-preschoolers
#9
Ariane Séguin-Lemire, Martine Hébert, Louise Cossette, Rachel Langevin
The aim of the present study was to investigate the evolution of emotion regulation competencies in sexually abused preschoolers. Children's emotion regulation abilities and their emotional lability and negativity were assessed shortly after disclosure of sexual abuse and one year later, and compared to those of non-abused children. A sample of 47 sexually abused (37 girls, 10 boys) and 74 non-abused children (54 girls, 20 boys), aged 3-7 years (M=56.83months; SD=9.55), participated in the study. Parents and daycare educators or teachers completed the Emotion Regulation Checklist (Shields & Cicchetti, 1997) and an adapted version of the History of Victimization Form (Parent & Hébert, 2006)...
December 5, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27931282/rnai-mediated-downregulation-of-fkbp14-suppresses-the-growth-of-human-ovarian-cancer-cells
#10
Meng Lu, Yi Miao, Lan Qi, Mingzhu Bai, Jiarong Zhang, Youji Feng
FKBP14 belongs to the family of FK506-binding proteins (FKBPs). Altered expression of FKBPs has been reported in several malignancies. This study aimed to reveal the expression profile of FKBP14 in ovarian cancer and evaluate whether FKBP14 is a molecular target for cancer therapy. We found that the FKBP14 mRNA level was significantly higher in ovarian cancer tissues than in normal tissues. FKBP14 expression was then knocked down in two ovarian cancer cell lines, SKOV3 and HO8910 cells, by a lentiviral short hairpin RNA (shRNA) delivery system...
May 2016: Oncology Research
https://www.readbyqxmd.com/read/27931255/wealth-and-cardiovascular-health-a-cross-sectional-study-of-wealth-related-inequalities-in-the-awareness-treatment-and-control-of-hypertension-in-high-middle-and-low-income-countries
#11
Benjamin Palafox, Martin McKee, Dina Balabanova, Khalid F AlHabib, Alvaro Jr Avezum, Ahmad Bahonar, Noorhassim Ismail, Jephat Chifamba, Clara K Chow, Daniel J Corsi, Gilles R Dagenais, Rafael Diaz, Rajeev Gupta, Romaina Iqbal, Manmeet Kaur, Rasha Khatib, Annamarie Kruger, Iolanthe Marike Kruger, Fernando Lanas, Patricio Lopez-Jaramillo, Fu Minfan, Viswanathan Mohan, Prem K Mony, Aytekin Oguz, Lia M Palileo-Villanueva, Pablo Perel, Paul Poirier, Sumathy Rangarajan, Lei Rensheng, Annika Rosengren, Biju Soman, David Stuckler, S V Subramanian, Koon Teo, Lungiswa P Tsolekile, Andreas Wielgosz, Peng Yaguang, Karen Yeates, Mo Yongzhen, Khalid Yusoff, Rita Yusuf, Afzalhussein Yusufali, Katarzyna Zatońska, Salim Yusuf
BACKGROUND: Effective policies to control hypertension require an understanding of its distribution in the population and the barriers people face along the pathway from detection through to treatment and control. One key factor is household wealth, which may enable or limit a household's ability to access health care services and adequately control such a chronic condition. This study aims to describe the scale and patterns of wealth-related inequalities in the awareness, treatment and control of hypertension in 21 countries using baseline data from the Prospective Urban and Rural Epidemiology study...
December 8, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27931230/feasibility-and-efficacy-of-gemcitabine-and-docetaxel-combination-chemotherapy-for-bone-and-soft-tissue-sarcomas-multi-institutional-retrospective-analysis-of-134-patients
#12
Kazuhiro Tanaka, Susumu Joyama, Hirokazu Chuman, Hiroaki Hiraga, Hideo Morioka, Hideki Yoshikawa, Masami Hosaka, Mitsuru Takahashi, Tadahiko Kubo, Hiroshi Hatano, Mitsunori Kaya, Junya Toguchida, Yoshihiro Nishida, Akihito Nagano, Hiroshi Tsumura, Yukihide Iwamoto
BACKGROUND: Bone and soft tissue sarcomas (BSTS) are rare malignant tumors. Recently, the combination of gemcitabine and docetaxel (GD) was shown to have activity as second-line setting in BSTS. However, the efficacy as first-line and adjuvant settings and precise profiles of adverse events in Japanese patients are not known yet. In the present study, the feasibility and efficacy of GD in patients with BSTS were investigated. METHODS: Patients with BSTS treated with GD in our institutions were retrospectively analyzed...
December 8, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27931137/impact-of-olive-oil-rich-diet-on-serum-omentin-and-adiponectin-levels-a-randomized-cross-over-clinical-trial-among-overweight-women
#13
Akram Kabiri, Mohammad Javad Hosseinzadeh-Attar, Fahimeh Haghighatdoost, Mohammadreza Eshraghian, Ahmad Esmaillzadeh
This study aimed to investigate the effect of olive oil-rich diet on omentin and adiponectin concentrations. This cross-over randomized trial included 17 overweight women. Participants were assigned to consume either a usual (16% saturated fatty acids [SFA] and 8% monounsaturated fatty acid [MUFA]) or an olive oil-rich diet (16% MUFA and 8% SFA) for 6 weeks crossing over after a 2-week washout period. There was no significant difference in the changes of omentin between two dietary interventions. However, in the adjusted model for polyunsaturated fatty acids and fat mass, usual diet tended to decrease omentin levels whilst olive oil-rich diet tended to increase (-56...
December 8, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27931097/novel-chlorinated-polyfluorinated-ether-sulfonates-and-legacy-per-polyfluoroalkyl-substances-placental-transfer-and-relationship-with-serum-albumin-and-glomerular-filtration-rate
#14
Yitao Pan, Yingshuang Zhu, Tongzhang Zheng, Qianqian Cui, Stephen L Buka, Bin Zhang, Yong Guo, Wei Xia, Leo Wai-Yin Yeung, Yuanyuan Li, Aifen Zhou, Lin Qiu, Hongxiu Liu, Minmin Jiang, Chuansha Wu, Shunqing Xu, Jiayin Dai
Per- and polyfluoroalkyl substances (PFASs) may cross the placental barrier and lead to fetal exposure. However, little is known about the factors that influence maternal-fetal transfer of these chemicals. PFAS concentrations were analyzed in 100 paired samples of human maternal sera collected in each trimester and cord sera at delivery; these samples were collected in Wuhan, China, 2014. Linear regression was used to estimate associations of transfer efficiencies with factors. Chlorinated polyfluorinated ether sulfonates (Cl-PFAESs: 6:2 and 8:2) were frequently detected (> 99%) in maternal and cord sera...
December 8, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27930984/bone-marrow-mesenchymal-stem-cells-and-their-conditioned-media-could-potentially-ameliorate-ovalbumin-induced-asthmatic-changes
#15
Mahdi Ahmadi, Reza Rahbarghazi, Mohammad Reza Aslani, Amir-Ali Shahbazfar, Masoumeh Kazemi, Rana Keyhanmanesh
BACKGROUND: The major feature of asthma is governed by chronic airway inflammation. This investigation was proposed to achieve the suitable candidate for ameliorating long-term chronic asthmatic changes of respiratory tract. METHODS: 36 rats were classified into healthy (C) and ovalbumin (OVA)-sensitized animals (S). To sensitize, the rats were exposed to OVA over a course of 32±1days. One day after sensitization, equal six different groups were subjected to experimental procedure (n=6); Rats only received intratracheally 50ml PBS (CPT and SPT groups), 50μl conditioned medium (CM) (CST and SST groups) and 50μl PBS containing 2×10(6) rat bone marrow-derived mesenchymal stem cells (rBMMSCs) (CCT and SCT groups)...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930936/sunlight-exposure-increases-vitamin-d-sufficiency-in-growing-pigs-fed-a-diet-formulated-to-exceed-requirements
#16
B M Alexander, B C Ingold, J L Young, S R Fensterseifer, P J Wechsler, K J Austin, D E Larson-Meyer
Traditional confinement practices limit exposure to sunlight and vitamin D synthesis, and vitamin insufficiency occurs even with dietary supplementation. The aim of this study was to determine the effect of limited sun exposure on serum concentration of vitamin D and the expression of vitamin D synthesizing enzymes in the liver and kidney of pigs on a vitamin D sufficient diet. White-pigmented grower pigs (29.7 ± 2.3 kg) fed 15% CP diet ad libitum providing >1,200 IU vitamin D3/kg of feed were exposed to sunlight for 1 h each day at solar noon for 14 d at the spring equinox (March pigs, n = 10) or summer solstice (June pigs, n = 5) and again before slaughter in June (March pigs) and September (June pigs)...
November 11, 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27930698/major-depression-as-a-complex-dynamic-system
#17
Angélique O J Cramer, Claudia D van Borkulo, Erik J Giltay, Han L J van der Maas, Kenneth S Kendler, Marten Scheffer, Denny Borsboom
In this paper, we characterize major depression (MD) as a complex dynamic system in which symptoms (e.g., insomnia and fatigue) are directly connected to one another in a network structure. We hypothesize that individuals can be characterized by their own network with unique architecture and resulting dynamics. With respect to architecture, we show that individuals vulnerable to developing MD are those with strong connections between symptoms: e.g., only one night of poor sleep suffices to make a particular person feel tired...
2016: PloS One
https://www.readbyqxmd.com/read/27930537/hypervascularity-is-more-frequent-in-medullary-thyroid-carcinoma-compared-with-papillary-thyroid-carcinoma
#18
Xingjian Lai, Meijuan Liu, Yu Xia, Liang Wang, Yalan Bi, Xiaoyi Li, Bo Zhang, Meng Yang, Qing Dai, Yuxin Jiang
This study was designed to retrospectively compare the sonographic features of medullary thyroid carcinoma (MTC) and the features of papillary thyroid carcinoma (PTC).A total of 97 patients with 127 MTCs between January 2000 and January 2016 and 107 consecutive patients with 132 PTCs were included in this study. Two radiologists retrospectively determined the sonographic features and compared the findings of MTCs and PTCs.Compared with the patients with PTCs, the patients with MTCs were older (46.9 years vs 42...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930394/the-changing-face-of-epidemiology-gender-disparities-in-citations
#19
Enrique F Schisterman, Chandra W Swanson, Ya-Ling Lu, Sunni L Mumford
BACKGROUND: Female biomedical scientists tend to publish fewer articles as last author than their male colleagues and accrue fewer citations per publication. We seek to understand whether epidemiology follows this pattern. METHODS: We gathered aggregate information on the current gender distribution of epidemiology departments (n=29 of 71 surveyed), societies (n=4 of 8), and journal editorial boards (n=6 of 6) using two online surveys and publicly available online information...
December 1, 2016: Epidemiology
https://www.readbyqxmd.com/read/27929542/autophagy-and-epithelial-mesenchymal-transition-an-intricate-interplay-in-cancer
#20
REVIEW
Mila Gugnoni, Valentina Sancisi, Gloria Manzotti, Greta Gandolfi, Alessia Ciarrocchi
Autophagy and epithelial to mesenchymal transition (EMT) are major biological processes in cancer. Autophagy is a catabolic pathway that aids cancer cells to overcome intracellular or environmental stress, including nutrient deprivation, hypoxia and drugs effect. EMT is a complex transdifferentiation through which cancer cells acquire mesenchymal features, including motility and metastatic potential. Recent observations indicate that these two processes are linked in a complex relationship. On the one side, cells that underwent EMT require autophagy activation to survive during the metastatic spreading...
December 8, 2016: Cell Death & Disease
keyword
keyword
80700
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"