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https://www.readbyqxmd.com/read/29679829/fulfilling-spawning-flow-requirements-for-potamodromous-cyprinids-in-a-restored-river-segment
#1
Isabel Boavida, Joaquim B Jesus, Vítor Pereira, Cátia Santos, Marisa Lopes, Rui M V Cortes
The Baixo Sabor hydroelectric scheme was recently constructed (began operating in 2015), blocking fish migration immediately at the river mouth. As a compensation measure for spawning habitat loss the Vilariça River which confluences with Sabor River, immediately downstream from the Baixo Sabor scheme, was chosen for rehabilitation site as an attempt to replace the spawning grounds lost in Sabor River for the potamodromous cyprinid Iberian barbel (Luciobarbus bocagei). Restoration activities included: placement of submerged weirs with fish ramps to increase the lotic/lentic sequence, bank reinforcement, boulder placement and river water profile increase...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679788/factors-affecting-ambient-endotoxin-and-particulate-matter-concentrations-around-air-vents-of-subway-stations-in-south-korea
#2
Wha Me Park, Dong Uk Park, Sung Ho Hwang
Levels of airborne endotoxins and particulate matter less than 10 μm and 2.5 μm in diameter (PM) were measured in the air vents of subway stations in Seoul, South Korea, and factors affecting both pollutants were analyzed. The measurements were completed from March 2016 to February 2017 for eight air vents situated at the ground level around the subway stations. A total of 166 air samples were collected and analyzed using the kinetic limulus amebocyte lysate assay. Endotoxin levels ranged from not detected to 1...
April 14, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679707/enhanced-delivery-of-fixed-dose-combination-of-synergistic-antichagasic-agents-posaconazole-benznidazole-based-on-amorphous-solid-dispersions
#3
Camila Bezerra Melo Figueirêdo, Daniela Nadvorny, Amanda Carla Quintas de Medeiros Vieira, Giovanna Christinne Rocha de Medeiros Schver, José Lamartine Soares Sobrinho, Pedro José Rolim Neto, Ping I Lee, Monica Felts de La Roca Soares
Posaconazole (PCZ) and benznidazole (BNZ) are known to show synergetic effect in treating the acute and chronic phases of Chagas disease, a neglected parasitic disease. However, as both compounds are poorly water soluble, the development of amorphous solid dispersions (ASDs) of a PCZ/BNZ fixed-dose combination in a water-soluble polymer becomes an attractive option to increase their apparent solubility and dissolution rate, potentially improving their oral bioavailability. The initial approach was to explore solvent evaporated solid dispertion (SD) systems for a PCZ/BNZ 50:50 (wt%) combination at several total drug loading levels (from SD with 10% to 50% drug loading) in water-soluble carriers, including polyvinylpyrrolidone (PVP K-30) and vinylpyrrolidone-vinyl acetate copolymer (PVPVA 64)...
April 18, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29679583/preservation-of-salivary-function-following-extracapsular-dissection-for-tumors-of-the-parotid-gland
#4
Sung Joon Park, Sungjun Han, Hyo-Jung Lee, Soon-Hyun Ahn, Woo-Jin Jeong
PURPOSE: This study evaluated salivary function after extracapsular dissection (ECD) compared with partial superficial parotidectomy (PSP) and classic superficial parotidectomy (CSP) of benign parotid gland tumors. The authors hypothesized that ECD would be superior to PSP and CSP in preserving postoperative salivary function. MATERIALS AND METHODS: Retrospective analyses were performed for 43 consecutive patients who underwent parotidectomies of benign parotid tumors performed by a single experienced surgeon...
March 28, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29679492/knowledge-based-automated-planning-for-oropharyngeal-cancer
#5
Aaron Babier, Justin J Boutilier, Andrea L McNiven, Timothy C Y Chan
PURPOSE: To automatically generate radiation therapy plans for oropharynx patients by com-bining knowledge-based planning (KBP) predictions with an inverse optimization (IO) pipeline. METHODS: We developed two KBP approaches, the bagging query (BQ) method and the generalized principal component analysis-based (gPCA) method, to predict achievable dose volume histograms (DVHs). These approaches generalize existing methods by predicting physically feasible organ-at-risk (OAR) and target DVHs in sites with multiple targets...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29679363/proangiogenic-and-profibrotic-markers-in-pulmonary-sarcoidosis
#6
I Tuleta, L Biener, C Pizarro, G Nickenig, D Skowasch
The aim of our study was to determine the blood levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, fibroblast growth factor (FGF)-2, and platelet-derived growth factor (PDGF)-AB in different stages of pulmonary sarcoidosis. There were 92 patients in sarcoidosis stages I + II, III, and IV enrolled into the study. All the patients underwent lung diffusing capacity and blood sampling. We found that VEGF levels differed significantly between the stage groups with the peak VEGF concentrations in stage III...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679212/diagnostic-performance-of-dual-energy-ct-for-the-detection-of-bone-marrow-oedema-a-systematic-review-and-meta-analysis
#7
Chong Hyun Suh, Seong Jong Yun, Wook Jin, Sun Hwa Lee, So Young Park, Chang-Woo Ryu
OBJECTIVES: The aim of this systematic review and meta-analysis was to assess the sensitivity and specificity of dual-energy CT (DECT) for the detection of bone marrow oedema (BME). METHODS: An electronic search of the PubMed and EMBASE databases was conducted. Bivariate modelling and hierarchical summary receiver-operating characteristic modelling were performed to evaluate the overall diagnostic performance of DECT for BME. Subgroup analysis was performed according to the assessment type (qualitative vs...
April 20, 2018: European Radiology
https://www.readbyqxmd.com/read/29679205/changes-in-the-position-and-volume-of-inactive-x-chromosomes-during-the-g0-g1-transition
#8
Guoliang Lyu, Tan Tan, Yiting Guan, Lei Sun, Qianjin Liang, Wei Tao
In female mammals, each cell silences one X chromosome by converting it into transcriptionally inert heterochromatin. The inactivation is concomitant with epigenetic changes including methylation of specific histone residues and incorporation of macroH2A. Such epigenetic changes may exert influence on the positioning of the inactive X chromosome (Xi) within the nucleus beyond the level of chromatin structure. However, the dynamic positioning of the inactive X chromosome during cell cycle remains unclear. Here, we show that H3K27me3 is a cell-cycle-independent marker for the inactivated X chromosomes in WI38 cells...
April 21, 2018: Chromosome Research
https://www.readbyqxmd.com/read/29679138/sexual-quality-of-life-body-image-distress-and-psychosocial-outcomes-in-colorectal-cancer-a-longitudinal-study
#9
Jennifer Barsky Reese, Elizabeth Handorf, Jennifer A Haythornthwaite
PURPOSE: The objectives were to assess changes in sexual QOL and body image distress over time and to examine longitudinal associations between sexual QOL and body image variables with psychosocial outcomes in a sample of colorectal cancer patients. METHODS: Participants (N = 141) completed a mail-based survey assessing sexual QOL [sexual distress (ISS), treatment impact on sexual function (SFQ), sexual function (FSFI; IIEF)], body image distress (BIS), and psychosocial outcomes [relationship quality (DAS-4), depressive symptoms (CESD-SF), and health-related QOL (HRQOL; FACT-C)]; 88 patients completed 6-month follow-up surveys (62%)...
April 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29679115/analyzing-chromatographic-data-using-multilevel-modeling
#10
Paweł Wiczling
It is relatively easy to collect chromatographic measurements for a large number of analytes, especially with gradient chromatographic methods coupled with mass spectrometry detection. Such data often have a hierarchical or clustered structure. For example, analytes with similar hydrophobicity and dissociation constant tend to be more alike in their retention than a randomly chosen set of analytes. Multilevel models recognize the existence of such data structures by assigning a model for each parameter, with its parameters also estimated from data...
April 21, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29679033/innovatively-therapeutic-strategy-on-lung-cancer-by-daily-drinking-antioxidative-plasmon-induced-activated-water
#11
Chien-Kai Wang, Hsiao-Chien Chen, Sheng-Uei Fang, Chia-Wen Ho, Cheng-Jeng Tai, Chih-Ping Yang, Yu-Chuan Liu
Many human diseases are inflammation-related, such as cancer and those associated with aging. Previous studies demonstrated that plasmon-induced activated (PIA) water with electron-doping character, created from hot electron transfer via decay of excited Au nanoparticles (NPs) under resonant illumination, owns reduced hydrogen-bonded networks and physchemically antioxidative properties. In this study, it is demonstrated PIA water dramatically induced a major antioxidative Nrf2 gene in human gingival fibroblasts which further confirms its cellular antioxidative and anti-inflammatory properties...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678925/role-of-the-novel-endoribonuclease-slfn14-and-its-disease-causing-mutations-in-ribosomal-degradation
#12
Sarah J Fletcher, Vera P Pisareva, Abdullah Khan, Andrew Tcherepanov, Neil V Morgan, Andrey V Pisarev
Platelets are anucleate and mostly ribosome-free cells within the bloodstream, derived from megakaryocytes within bone marrow and crucial for cessation of bleeding at sites of injury. Inherited thrombocytopenias are a group of disorders characterized by a low platelet count and are frequently associated with excessive bleeding. SLFN14 is one of the most recently discovered genes linked to inherited thrombocytopenia where several heterozygous missense mutations in SLFN14 were identified to cause defective megakaryocyte maturation and platelet dysfunction...
April 20, 2018: RNA
https://www.readbyqxmd.com/read/29678815/feedback-between-tissue-packing-and-neurogenesis-in-the-zebrafish-neural-tube
#13
Tom W Hiscock, Joel B Miesfeld, Kishore R Mosaliganti, Brian A Link, Sean G Megason
Balancing the rate of differentiation and proliferation in developing tissues is essential to produce organs of robust size and composition. Whilst many molecular regulators have been established, how these connect to physical and geometrical aspects of tissue architecture is poorly understood. Here, using high-resolution timelapse imaging, we find that changes to cell geometry associated with dense tissue packing play a significant role in regulating differentiation rate in the zebrafish neural tube. Specifically, progenitors that are displaced away from the apical surface due to crowding tend to differentiate, in a Notch-dependent manner...
April 20, 2018: Development
https://www.readbyqxmd.com/read/29678748/severity-of-allergic-rhinitis-assessed-by-urine-metabolomic-profiling-proof-of-concept
#14
Darryl J Adamko, Mona M Khamis, Lisa M Steacy, Shana Regush, Rhonda Bryce, Anne K Ellis
Patients with chronic airway diseases tend to become "accustomed" to their impairments and fail to recognize the significance of their symptoms. We suggest that a metabolomic approach could become a diagnostic/monitoring solution in clinical trials or in a typical doctor's office.
April 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29678726/corticosterone-profiles-in-northern-cardinals-cardinalis-cardinalis-do-levels-vary-through-life-history-stages
#15
Benjamin M Duckworth, Jodie M Jawor
As animals move through life history stages, energy requirements for each stage will vary. Both daily and annual variation in the glucocoriticoid hormones (specifically corticosterone, or CORT, in birds) helps provide the variable energy needed through life history stages. In many bird species, CORT is higher in the breeding season when energy demands can be quite high and is often lower in the non-breeding season. Additionally, CORT has a role to play in the response to stressful stimuli and the level to which CORT is elevated following stressful events can vary through the annual cycle as well...
April 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29678704/clinical-parameters-to-distinguish-silent-corticotroph-adenomas-from-other-nonfunctioning-pituitary-adenomas
#16
Daham Kim, Cheol Ryong Ku, Se Hee Park, Ju Hyung Moon, Eui Hyun Kim, Sun Ho Kim, Eun Jig Lee
BACKGROUND: It is difficult to distinguish silent corticotroph adenomas (SCAs) from other nonfunctioning pituitary adenomas (NFPAs) preoperatively. This study aimed to determine the preoperative clinical parameters associated with SCAs. METHODS: This was a retrospective single-center study of patients who underwent surgery for NFPAs during 2011-2016 in our tertiary hospital and who had preoperative combined pituitary function test (CPFT) and immunohistochemical staining results available...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678685/success-rate-and-factors-predictive-of-redo-radiofrequency-ablation-of-perforator-veins
#17
Afsha Aurshina, Enrico Ascher, Lauren Mount, Amrit Hingorani, Natalie Marks, Anil Hingorani
OBJECTIVE: Radiofrequency ablation (RFA) is increasingly being employed for treatment of perforator vein insufficiency and venous ulcer healing. Previous studies have shown a closure rate of 60% to 80% in incompetent perforator veins (IPVs) with RFA. The purpose of the study was to determine the utility of a redo RFA for symptomatic recanalized perforators and to predict factors associated with recanalization. METHODS: A retrospective analysis of 642 procedures in 256 patients with venous insufficiency due to IPVs from 2009 to 2015 was conducted...
April 17, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29678663/giant-renal-hemangioma-in-an-adolescent-girl-a-very-rare-entity
#18
Tayfun Oktar, M İrfan Dönmez, Zuhal Bayramoglu, Yasemin Ozluk, Ozge Tepe, Isin Kilicaslan, Ibrahim Adaletli, Haluk Ander
Hemangiomas are benign vascular tumors of childhood and they usually tend to be located in the upper parts of the body (head and neck). However, renal hemangiomas are very rare and usually occur to be small (1-2 cm) in size. Here, we report an adolescent girl with a giant renal hemangioma of 15 cm diameter.
April 17, 2018: Urology
https://www.readbyqxmd.com/read/29678598/the-benefits-of-defining-snacks
#19
Julie M Hess, Joanne L Slavin
Whether eating a "snack" is considered a beneficial or detrimental behavior is largely based on how "snack" is defined. The term "snack food" tends to connote energy-dense, nutrient-poor foods high in nutrients to limit (sugar, sodium, and/or saturated fat) like cakes, cookies, chips and other salty snacks, and sugar-sweetened beverages. Eating a "snack food" is often conflated with eating a "snack," however, leading to an overall perception of snacks as a dietary negative...
April 17, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29678587/folding-and-stabilizing-membrane-proteins-in-amphipol-a8-35
#20
REVIEW
Christel Le Bon, Anaïs Marconnet, Sandrine Masscheleyn, Jean-Luc Popot, Manuela Zoonens
Membrane proteins (MPs) are important pharmacological targets because of their involvement in many essential cellular processes whose dysfunction can lead to a large variety of diseases. A detailed knowledge of the structure of MPs and the molecular mechanisms of their activity is essential to the design of new therapeutic agents. However, studying MPs in vitro is challenging, because it generally implies their overexpression under a functional form, followed by their extraction from membranes and purification...
April 17, 2018: Methods: a Companion to Methods in Enzymology
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